zinc metalloproteinase family protein contains an HEXXH motif characteristic of metallopeptidases; contains a Jacalin-like lectin domain that may bind mono- or oligosaccharides
Putative peptidase family; This family of proteins is functionally uncharacterized. However, ...
5-430
0e+00
Putative peptidase family; This family of proteins is functionally uncharacterized. However, it does contain an HEXXH motif characteriztic of metallopeptidases. This protein is found mainly in fungi. Proteins in this family are typically between 625 to 773 amino acids in length.
:
Pssm-ID: 432283 Cd Length: 426 Bit Score: 698.73 E-value: 0e+00
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly ...
538-681
4.41e-38
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. Taxonomic distribution is not restricted to plants, the domain is also found in various mammalian proteins, for example.
The actual alignment was detected with superfamily member cd09613:
Pssm-ID: 446042 Cd Length: 124 Bit Score: 137.55 E-value: 4.41e-38
Putative peptidase family; This family of proteins is functionally uncharacterized. However, ...
5-430
0e+00
Putative peptidase family; This family of proteins is functionally uncharacterized. However, it does contain an HEXXH motif characteriztic of metallopeptidases. This protein is found mainly in fungi. Proteins in this family are typically between 625 to 773 amino acids in length.
Pssm-ID: 432283 Cd Length: 426 Bit Score: 698.73 E-value: 0e+00
Jacalin-like lectin domain of putative metalloproteases and similar proteins; Members of this ...
538-681
4.41e-38
Jacalin-like lectin domain of putative metalloproteases and similar proteins; Members of this family, which appears restricted to fungi, co-occur with protein domains that contain an HExxH motif characteristic of metallopeptidases. They have not been functionally characterized.
Pssm-ID: 187709 Cd Length: 124 Bit Score: 137.55 E-value: 4.41e-38
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
600-681
2.28e-07
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.
Pssm-ID: 214909 [Multi-domain] Cd Length: 128 Bit Score: 50.31 E-value: 2.28e-07
Putative peptidase family; This family of proteins is functionally uncharacterized. However, ...
5-430
0e+00
Putative peptidase family; This family of proteins is functionally uncharacterized. However, it does contain an HEXXH motif characteriztic of metallopeptidases. This protein is found mainly in fungi. Proteins in this family are typically between 625 to 773 amino acids in length.
Pssm-ID: 432283 Cd Length: 426 Bit Score: 698.73 E-value: 0e+00
Jacalin-like lectin domain of putative metalloproteases and similar proteins; Members of this ...
538-681
4.41e-38
Jacalin-like lectin domain of putative metalloproteases and similar proteins; Members of this family, which appears restricted to fungi, co-occur with protein domains that contain an HExxH motif characteristic of metallopeptidases. They have not been functionally characterized.
Pssm-ID: 187709 Cd Length: 124 Bit Score: 137.55 E-value: 4.41e-38
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly ...
604-681
1.32e-13
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. Taxonomic distribution is not restricted to plants, the domain is also found in various mammalian proteins, for example.
Pssm-ID: 187706 Cd Length: 128 Bit Score: 67.81 E-value: 1.32e-13
Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin ...
604-681
6.55e-09
Jacalin-like lectin domain of griffithsin and related proteins; Griffithsin is a lectin isolated from a red alga, which has shown potential as an inhibitor of viral entry, exhibiting antiviral activity against HIV and SARS. The biological functions of griffithsin and griffithsin-like proteins with respect to their source organisms are not known.
Pssm-ID: 187710 Cd Length: 128 Bit Score: 54.71 E-value: 6.55e-09
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a ...
600-681
2.28e-07
Jacalin-like lectin domain; This entry represents a mannose-binding lectin domain with a beta-prism fold consisting of three 4-stranded beta-sheets, with an internal pseudo 3-fold symmetry. Some lectins in this group stimulate distinct T- and B- cell functions, such as Jacalin, which binds to the T-antigen and acts as an agglutinin. This domain is found in 1 to 6 copies in lectins. The domain is also found in the salt-stress induced protein from rice and an animal prostatic spermine-binding protein.
Pssm-ID: 214909 [Multi-domain] Cd Length: 128 Bit Score: 50.31 E-value: 2.28e-07
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a ...
597-671
5.11e-04
Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins; ZG16p is a conserved secreted vertebrate protein with tissue-specific expression profiles, which might play a role in glycoprotein secretion, perhaps as a linker protein that participates in the formation and/or transport of the zymogen granule. Its paralog ZG16b (PAUF) has been associated with roles in gene regulation and cancer. This domain family also contains mammalian proteins labelled as prostatic spermine-binding protein (SBP) and salivary-gland specific secreted proteins.
Pssm-ID: 187707 [Multi-domain] Cd Length: 128 Bit Score: 40.38 E-value: 5.11e-04
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly ...
589-634
1.27e-03
Jacalin-like lectin domain; Jacalin-like lectins are sugar-binding protein domains mostly found in plants. They adopt a beta-prism topology consistent with a circularly permuted three-fold repeat of a structural motif. Proteins containing this domain may bind mono- or oligosaccharides with high specificity. The domain can occur in tandem-repeat arrangements with up to six copies, and in architectures combined with a variety of other functional domains. Taxonomic distribution is not restricted to plants, the domain is also found in various mammalian proteins, for example.
Pssm-ID: 187706 Cd Length: 128 Bit Score: 39.31 E-value: 1.27e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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