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Conserved domains on  [gi|1815793461|gb|QIE55298|]
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methyltransferase domain-containing protein [Pikeienuella piscinae]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 1008156)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK01683 super family cl30594
trans-aconitate 2-methyltransferase; Provisional
 9-257 7.79e-63

trans-aconitate 2-methyltransferase; Provisional


The actual alignment was detected with superfamily member PRK01683:

Pssm-ID: 234970  Cd Length: 258  Bit Score: 197.86  E-value: 7.79e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461   9 WKVAAYEAFGDLRLRPALDLLARVPELPAGALVDLGCGSGAAASALRARFPGRRLIGVDRASEMLAKAAPLLDEA--IEA 86
Cdd:PRK01683    4 WNPSLYLKFEDERTRPARDLLARVPLENPRYVVDLGCGPGNSTELLVERWPAARITGIDSSPAMLAEARSRLPDCqfVEA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  87 DIADWGPAAAA-LIFSNAALHWLPDHATLIPALFAALAPGGVLAVQMPGQLDRPSHRTM------------IGAAAAIRp 153
Cdd:PRK01683   84 DIASWQPPQALdLIFANASLQWLPDHLELFPRLVSLLAPGGVLAVQMPDNLDEPSHVLMrevaengpweqnLPDRGARR- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461 154 dlfcgwKPFPGPlplPDYAGLLPRAG--LDLWETEYLQRLGPADGgghpVRAFVSATGARPILALLDAAERARFEAGWDE 231
Cdd:PRK01683  163 ------APLPPP---HAYYDALAPAAcrVDIWHTTYYHPMPSAQA----IVEWVKGTGLRPFLDPLTESEQAAFLAAYLA 229

                         250       260
                  ....*....|....*....|....*.
gi 1815793461 232 ALGAAYPVGPDGCCWFPFRRFFFVAR 257
Cdd:PRK01683  230 RIAEAYPLQADGKVLLAFPRLFIVAR 255
 
Name Accession Description Interval E-value
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 9-257 7.79e-63

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 197.86  E-value: 7.79e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461   9 WKVAAYEAFGDLRLRPALDLLARVPELPAGALVDLGCGSGAAASALRARFPGRRLIGVDRASEMLAKAAPLLDEA--IEA 86
Cdd:PRK01683    4 WNPSLYLKFEDERTRPARDLLARVPLENPRYVVDLGCGPGNSTELLVERWPAARITGIDSSPAMLAEARSRLPDCqfVEA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  87 DIADWGPAAAA-LIFSNAALHWLPDHATLIPALFAALAPGGVLAVQMPGQLDRPSHRTM------------IGAAAAIRp 153
Cdd:PRK01683   84 DIASWQPPQALdLIFANASLQWLPDHLELFPRLVSLLAPGGVLAVQMPDNLDEPSHVLMrevaengpweqnLPDRGARR- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461 154 dlfcgwKPFPGPlplPDYAGLLPRAG--LDLWETEYLQRLGPADGgghpVRAFVSATGARPILALLDAAERARFEAGWDE 231
Cdd:PRK01683  163 ------APLPPP---HAYYDALAPAAcrVDIWHTTYYHPMPSAQA----IVEWVKGTGLRPFLDPLTESEQAAFLAAYLA 229

                         250       260
                  ....*....|....*....|....*.
gi 1815793461 232 ALGAAYPVGPDGCCWFPFRRFFFVAR 257
Cdd:PRK01683  230 RIAEAYPLQADGKVLLAFPRLFIVAR 255
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
36-132 5.59e-31

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 110.68  E-value: 5.59e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  36 PAGALVDLGCGSGAAASALRARFPGRRLIGVDRASEMLAKAAPLLDEA--IEADIADWGPAAAA-LIFSNAALHWLPDHA 112
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNVrfVVADLRDLDPPEPFdLVVSNAALHWLPDHA 80

                          90       100
                  ....*....|....*....|
gi 1815793461 113 TLIPALFAALAPGGVLAVQM 132
Cdd:COG4106    81 ALLARLAAALAPGGVLAVQV 100
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 14-135 2.11e-15

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 73.47  E-value: 2.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  14 YEAFGDLRLRPALDLLARVPELPA---GALVDLGCGSGAAASALRARFPGRRLIGVDRASEMLAKAAPLLDEA---IEAD 87
Cdd:TIGR02072   9 YDRHAKIQREMAKRLLALLKEKGIfipASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKLSENvqfICGD 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1815793461  88 I--ADWGPAAAALIFSNAALHWLPDHATLIPALFAALAPGGVLAVQMPGQ 135
Cdd:TIGR02072  89 AekLPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGP 138
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 42-126 5.77e-13

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 63.35  E-value: 5.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  42 DLGCGSGAAASALRARFpGRRLIGVDRASEMLAKAAPLLDEA------IEADIADWGPAAAA--LIFSNAALHWL--PDH 111
Cdd:pfam13649   3 DLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAglnvefVQGDAEDLPFPDGSfdLVVSSGVLHHLpdPDL 81

                          90
                  ....*....|....*
gi 1815793461 112 ATLIPALFAALAPGG 126
Cdd:pfam13649  82 EAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 40-131 2.42e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 50.89  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  40 LVDLGCGSGAAASALrARFPGRRLIGVDRASEMLAKAAPLLDEA-------IEADIADW---GPAAAALIFSNAALHWLP 109
Cdd:cd02440     2 VLDLGCGTGALALAL-ASGPGARVTGVDISPVALELARKAAAALladnvevLKGDAEELppeADESFDVIISDPPLHHLV 80

                          90       100
                  ....*....|....*....|...
gi 1815793461 110 -DHATLIPALFAALAPGGVLAVQ 131
Cdd:cd02440    81 eDLARFLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 9-257 7.79e-63

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 197.86  E-value: 7.79e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461   9 WKVAAYEAFGDLRLRPALDLLARVPELPAGALVDLGCGSGAAASALRARFPGRRLIGVDRASEMLAKAAPLLDEA--IEA 86
Cdd:PRK01683    4 WNPSLYLKFEDERTRPARDLLARVPLENPRYVVDLGCGPGNSTELLVERWPAARITGIDSSPAMLAEARSRLPDCqfVEA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  87 DIADWGPAAAA-LIFSNAALHWLPDHATLIPALFAALAPGGVLAVQMPGQLDRPSHRTM------------IGAAAAIRp 153
Cdd:PRK01683   84 DIASWQPPQALdLIFANASLQWLPDHLELFPRLVSLLAPGGVLAVQMPDNLDEPSHVLMrevaengpweqnLPDRGARR- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461 154 dlfcgwKPFPGPlplPDYAGLLPRAG--LDLWETEYLQRLGPADGgghpVRAFVSATGARPILALLDAAERARFEAGWDE 231
Cdd:PRK01683  163 ------APLPPP---HAYYDALAPAAcrVDIWHTTYYHPMPSAQA----IVEWVKGTGLRPFLDPLTESEQAAFLAAYLA 229

                         250       260
                  ....*....|....*....|....*.
gi 1815793461 232 ALGAAYPVGPDGCCWFPFRRFFFVAR 257
Cdd:PRK01683  230 RIAEAYPLQADGKVLLAFPRLFIVAR 255
PRK14103 PRK14103
trans-aconitate 2-methyltransferase; Provisional
 9-257 1.01e-59

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 184509  Cd Length: 255  Bit Score: 189.51  E-value: 1.01e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461   9 WKVAAYEAFGDLRLRPALDLLARVPELPAGALVDLGCGSGAAASALRARFPGRRLIGVDRASEMLAKAAPLLDEAIEADI 88
Cdd:PRK14103    2 WDPDVYLAFADHRGRPFYDLLARVGAERARRVVDLGCGPGNLTRYLARRWPGAVIEALDSSPEMVAAARERGVDARTGDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  89 ADWGPAA-AALIFSNAALHWLPDHATLIPALFAALAPGGVLAVQMPGQLDRPSHRTMIGAAAAIRpdlfcgWKPFPGPLP 167
Cdd:PRK14103   82 RDWKPKPdTDVVVSNAALQWVPEHADLLVRWVDELAPGSWIAVQVPGNFDAPSHAAVRALARREP------WAKLLRDIP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461 168 L---------PDYAGLLPRAG--LDLWETEYLQRLgpadGGGHPVRAFVSATGARPILALLDAAERARFEAGWDEALGAA 236
Cdd:PRK14103  156 FrvgavvqtpAGYAELLTDAGckVDAWETTYVHQL----TGEDPVLDWITGTALRPVRERLSDDSWEQFRAELIPLLREA 231

                         250       260
                  ....*....|....*....|.
gi 1815793461 237 YPVGPDGCCWFPFRRFFFVAR 257
Cdd:PRK14103  232 YPPRADGTTFFPFRRVFVVAR 252
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
36-132 5.59e-31

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 110.68  E-value: 5.59e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  36 PAGALVDLGCGSGAAASALRARFPGRRLIGVDRASEMLAKAAPLLDEA--IEADIADWGPAAAA-LIFSNAALHWLPDHA 112
Cdd:COG4106     1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNVrfVVADLRDLDPPEPFdLVVSNAALHWLPDHA 80

                          90       100
                  ....*....|....*....|
gi 1815793461 113 TLIPALFAALAPGGVLAVQM 132
Cdd:COG4106    81 ALLARLAAALAPGGVLAVQV 100
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
25-129 8.35e-18

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 78.50  E-value: 8.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  25 ALDLLARVPELPAGALVDLGCGSGAAASALRARfpGRRLIGVDRASEMLAKAA--PLLDEAIEADIAD--WGPAAAALIF 100
Cdd:COG4976    35 AEELLARLPPGPFGRVLDLGCGTGLLGEALRPR--GYRLTGVDLSEEMLAKARekGVYDRLLVADLADlaEPDGRFDLIV 112

                          90       100
                  ....*....|....*....|....*....
gi 1815793461 101 SNAALHWLPDHATLIPALFAALAPGGVLA 129
Cdd:COG4976   113 AADVLTYLGDLAAVFAGVARALKPGGLFI 141
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 13-131 1.23e-16

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 75.72  E-value: 1.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  13 AYEAFGDLRLRPALD-LLARVPELPAGALV-DLGCGSGAAASALRARFpGRRLIGVDRASEMLAKAAPLLDEA------- 83
Cdd:COG0500     1 PWDSYYSDELLPGLAaLLALLERLPKGGRVlDLGCGTGRNLLALAARF-GGRVIGIDLSPEAIALARARAAKAglgnvef 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1815793461  84 IEADIADWGPAAAA---LIFSNAALHWLPDH--ATLIPALFAALAPGGVLAVQ 131
Cdd:COG0500    80 LVADLAELDPLPAEsfdLVVAFGVLHHLPPEerEALLRELARALKPGGVLLLS 132
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 14-135 2.11e-15

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 73.47  E-value: 2.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  14 YEAFGDLRLRPALDLLARVPELPA---GALVDLGCGSGAAASALRARFPGRRLIGVDRASEMLAKAAPLLDEA---IEAD 87
Cdd:TIGR02072   9 YDRHAKIQREMAKRLLALLKEKGIfipASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKLSENvqfICGD 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1815793461  88 I--ADWGPAAAALIFSNAALHWLPDHATLIPALFAALAPGGVLAVQMPGQ 135
Cdd:TIGR02072  89 AekLPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGP 138
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 23-133 9.02e-14

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 66.19  E-value: 9.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  23 RPALDLLARVPELPAGALVDLGCGSGAAASALRARfpGRRLIGVDRASEMLAKAAPLLDEA----IEADIADWGPAAAA- 97
Cdd:COG2227    11 DRRLAALLARLLPAGGRVLDVGCGTGRLALALARR--GADVTGVDISPEALEIARERAAELnvdfVQGDLEDLPLEDGSf 88

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1815793461  98 -LIFSNAALHWLPDHATLIPALFAALAPGGVLAVQMP 133
Cdd:COG2227    89 dLVICSEVLEHLPDPAALLRELARLLKPGGLLLLSTP 125
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 27-130 9.86e-14

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 66.56  E-value: 9.86e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  27 DLLARVPELPAGALVDLGCGSGAAASALRARfpGRRLIGVDRASEMLAKAAPLLDEA------IEADIADWGPAAAA--L 98
Cdd:COG2226    13 ALLAALGLRPGARVLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAglnvefVVGDAEDLPFPDGSfdL 90

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1815793461  99 IFSNAALHWLPDHATLIPALFAALAPGGVLAV 130
Cdd:COG2226    91 VISSFVLHHLPDPERALAEIARVLKPGGRLVV 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 42-126 5.77e-13

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 63.35  E-value: 5.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  42 DLGCGSGAAASALRARFpGRRLIGVDRASEMLAKAAPLLDEA------IEADIADWGPAAAA--LIFSNAALHWL--PDH 111
Cdd:pfam13649   3 DLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAglnvefVQGDAEDLPFPDGSfdLVVSSGVLHHLpdPDL 81

                          90
                  ....*....|....*
gi 1815793461 112 ATLIPALFAALAPGG 126
Cdd:pfam13649  82 EAALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 41-130 1.15e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 56.90  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  41 VDLGCGSGAAASALRARFPgrRLIGVDRASEMLAKAAPLLDEA----IEADIAD--WGPAAAALIFSNAALHWLPDHATL 114
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA--RVTGVDISPEMLELAREKAPREgltfVVGDAEDlpFPDNSFDLVLSSEVLHHVEDPERA 78

                          90
                  ....*....|....*.
gi 1815793461 115 IPALFAALAPGGVLAV 130
Cdd:pfam08241  79 LREIARVLKPGGILII 94
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 14-184 3.55e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 57.44  E-value: 3.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  14 YEAFGDLRLRPALDLLARVPELPaGALVDLGCGSGAAASALRARFPgrRLIGVDRASEMLAKAAPLLDEAIEADIADWGP 93
Cdd:pfam13489   1 YAHQRERLLADLLLRLLPKLPSP-GRVLDFGCGTGIFLRLLRAQGF--SVTGVDPSPIAIERALLNVRFDQFDEQEAAVP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  94 AAAA-LIFSNAALHWLPDHATLIPALFAALAPGGVLAVQMPGQLDRPSHRTMIGAAAAIRPDLFCgwkpfpgPLPLPDYA 172
Cdd:pfam13489  78 AGKFdVIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTPLASDEADRLLLEWPYLRPRNGHIS-------LFSARSLK 150

                         170
                  ....*....|..
gi 1815793461 173 GLLPRAGLDLWE 184
Cdd:pfam13489 151 RLLEEAGFEVVS 162
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 23-133 3.67e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 57.25  E-value: 3.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  23 RPALDLLARVPELPAGA-LVDLGCGSGAAASALrARFPGRRLIGVDRASEMLAKAAPLLDEA--------IEADIADWGP 93
Cdd:COG2230    37 EAKLDLILRKLGLKPGMrVLDIGCGWGGLALYL-ARRYGVRVTGVTLSPEQLEYARERAAEAgladrvevRLADYRDLPA 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1815793461  94 AAAA-LIFSNAALHWLPD--HATLIPALFAALAPGGVLAVQMP 133
Cdd:COG2230   116 DGQFdAIVSIGMFEHVGPenYPAYFAKVARLLKPGGRLLLHTP 158
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 41-128 4.58e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 55.45  E-value: 4.58e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  41 VDLGCGSGAAASALRARFPGRRLIGVDRASEMLAKAA----------PLLDEAIEADIADWGPAAAALIFSNAALHWLPD 110
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARerlaalgllnAVRVELFQLDLGELDPGSFDVVVASNVLHHLAD 80

                          90
                  ....*....|....*...
gi 1815793461 111 HATLIPALFAALAPGGVL 128
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGVL 98
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 40-131 2.42e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 50.89  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  40 LVDLGCGSGAAASALrARFPGRRLIGVDRASEMLAKAAPLLDEA-------IEADIADW---GPAAAALIFSNAALHWLP 109
Cdd:cd02440     2 VLDLGCGTGALALAL-ASGPGARVTGVDISPVALELARKAAAALladnvevLKGDAEELppeADESFDVIISDPPLHHLV 80

                          90       100
                  ....*....|....*....|...
gi 1815793461 110 -DHATLIPALFAALAPGGVLAVQ 131
Cdd:cd02440    81 eDLARFLEEARRLLKPGGVLVLT 103
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 17-130 1.78e-07

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 50.53  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  17 FGDLRL-------RPALD--LLAR-VPELPAGALVDLGCGSGAAASALRARFPGRRLIGVDRASEMLAKAA------PLL 80
Cdd:COG4123     8 FKQFRIiqprcgyRFGTDavLLAAfAPVKKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARrnvalnGLE 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1815793461  81 D--EAIEADIADWGPAAAA----LIFSN------------------AALHWLP-DHATLIPALFAALAPGGVLAV 130
Cdd:COG4123    88 DriTVIHGDLKEFAAELPPgsfdLVVSNppyfkagsgrkspdearaIARHEDAlTLEDLIRAAARLLKPGGRFAL 162
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 28-128 4.78e-07

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 49.03  E-value: 4.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  28 LLARVPELPAGALVDLGCGSGAAASALRARFPGRRLIGVDrASEM---LAK---AAPLLD--EAIEADI-ADWGPAAAAL 98
Cdd:COG2813    41 LLEHLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVD-VNARaveLARanaAANGLEnvEVLWSDGlSGVPDGSFDL 119

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1815793461  99 IFSNAALH---WLPDHAT--LIPALFAALAPGGVL 128
Cdd:COG2813   120 ILSNPPFHagrAVDKEVAhaLIADAARHLRPGGEL 154
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
21-130 3.56e-06

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 46.88  E-value: 3.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  21 RLRPAL---DLLARVPELPAGAL--VDLGCGSGAAASALRARfpGRRLIGVDRASEMLAKAAplldEAIEA--------- 86
Cdd:PRK11036   24 QIRQAIlwqDLDRLLAELPPRPLrvLDAGGGEGQTAIKLAEL--GHQVILCDLSAEMIQRAK----QAAEAkgvsdnmqf 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1815793461  87 ------DIADWGPAAAALIFSNAALHWLPDHATLIPALFAALAPGGVLAV 130
Cdd:PRK11036   98 ihcaaqDIAQHLETPVDLILFHAVLEWVADPKSVLQTLWSVLRPGGALSL 147
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 40-131 3.61e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 45.49  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  40 LVDLGCGSGAAASALRARF-PGRRLIGVDRASEMLAKAAPLLD-------EAIEADIAD----WGPAAAALIFSNAALHW 107
Cdd:pfam13847   7 VLDLGCGTGHLSFELAEELgPNAEVVGIDISEEAIEKARENAQklgfdnvEFEQGDIEElpelLEDDKFDVVISNCVLNH 86

                          90       100
                  ....*....|....*....|....
gi 1815793461 108 LPDHATLIPALFAALAPGGVLAVQ 131
Cdd:pfam13847  87 IPDPDKVLQEILRVLKPGGRLIIS 110
PRK15451 PRK15451
carboxy-S-adenosyl-L-methionine synthase CmoA;
36-130 1.88e-04

carboxy-S-adenosyl-L-methionine synthase CmoA;


Pssm-ID: 185348  Cd Length: 247  Bit Score: 41.94  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  36 PAGALVDLGCGSGAAASALR--ARFPGRRLIGVDRASEML--------AKAAPLLDEAIEADIADWGPAAAALIFSNAAL 105
Cdd:PRK15451   56 PGTQVYDLGCSLGAATLSVRrnIHHDNCKIIAIDNSPAMIercrrhidAYKAPTPVDVIEGDIRDIAIENASMVVLNFTL 135

                          90       100
                  ....*....|....*....|....*..
gi 1815793461 106 HWLP--DHATLIPALFAALAPGGVLAV 130
Cdd:PRK15451  136 QFLEpsERQALLDKIYQGLNPGGALVL 162
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 8-129 1.94e-04

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 41.67  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461   8 GWKVAAYEAFGDLRLRPALDLLARVPELPAGALVDLGCGSGAAASALRARfpGRRLIGVDRASEMLAKA--APLLDEAIE 85
Cdd:PRK10258   14 GRAAAHYEQHAELQRQSADALLAMLPQRKFTHVLDAGCGPGWMSRYWRER--GSQVTALDLSPPMLAQArqKDAADHYLA 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1815793461  86 ADIADWGPAAAA--LIFSNAALHWLPDHATLIPALFAALAPGGVLA 129
Cdd:PRK10258   92 GDIESLPLATATfdLAWSNLAVQWCGNLSTALRELYRVVRPGGVVA 137
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 28-128 4.23e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 39.88  E-value: 4.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  28 LLARVPELPAGALVDLGCGSGAAASALRARFPGRRLIGVD---RASEmLAK---AAPLLD--EAIEADI-ADWGPAAAAL 98
Cdd:pfam05175  23 LLEHLPKDLSGKVLDLGCGAGVLGAALAKESPDAELTMVDinaRALE-SARenlAANGLEngEVVASDVySGVEDGKFDL 101

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1815793461  99 IFSNAALH-WLPDHATLIPALFA----ALAPGGVL 128
Cdd:pfam05175 102 IISNPPFHaGLATTYNVAQRFIAdakrHLRPGGEL 136
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 29-130 1.35e-03

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 39.37  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  29 LARVPELPAGALVDLGCGSGAAASALRARFPGRRLIGVDRASE--MLAK--AAPLLDEAIEADIADW----GPAAAALIF 100
Cdd:PRK09328  101 LEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEalAVARrnAKHGLGARVEFLQGDWfeplPGGRFDLIV 180

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1815793461 101 SN------AALHWL--------PDHA------------TLIPALFAALAPGGVLAV 130
Cdd:PRK09328  181 SNppyipeADIHLLqpevrdhePHLAlfggedgldfyrRIIEQAPRYLKPGGWLLL 236
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 29-130 2.50e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 38.59  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1815793461  29 LARVPELPAGALVDLGCGSGAAASALRARFPGRRLIGVDRASEMLAKA---APLLD-----EAIEADIADW--GPAAAAL 98
Cdd:COG2890   105 LALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVArrnAERLGledrvRFLQGDLFEPlpGDGRFDL 184

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1815793461  99 IFSN------AALHWLP--------------------DHATLIPALFAALAPGGVLAV 130
Cdd:COG2890   185 IVSNppyipeDEIALLPpevrdheprlaldggedgldFYRRIIAQAPRLLKPGGWLLL 242
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 29-91 2.55e-03

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 38.22  E-value: 2.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1815793461  29 LARVPelPAGALVDLGCGSGAAASALRARFPGRRLIGVDRASE--MLAK--AAPLLDEAIEADIADW 91
Cdd:TIGR03534  81 LERLK--KGPRVLDLGTGSGAIALALAKERPDARVTAVDISPEalAVARknARRLGLENVEFLQGDW 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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