NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1835048639|gb|QJE26788|]
View 

helix-turn-helix transcriptional regulator (plasmid) [Staphylococcus caprae]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-134 4.24e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.08  E-value: 4.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835048639   1 MKTIKKKDQLILSATELFNKQGYNATGIDQIVEHANVATMTLYRNFKSKEKLIESVLLRREILYFSYLFDNEDLS----- 75
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEdprer 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1835048639  76 IENIVVRHLNWLENYHSNGCLFLKANEEyqnkNEEITKIVKQHKINLLNKLNDILKNEE 134
Cdd:COG1309    82 LRALLRAYLEFLAENPALARLLLAEAAE----LPELRAALRALLRRLRALLAELLRAGG 136
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-134 4.24e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.08  E-value: 4.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835048639   1 MKTIKKKDQLILSATELFNKQGYNATGIDQIVEHANVATMTLYRNFKSKEKLIESVLLRREILYFSYLFDNEDLS----- 75
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEdprer 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1835048639  76 IENIVVRHLNWLENYHSNGCLFLKANEEyqnkNEEITKIVKQHKINLLNKLNDILKNEE 134
Cdd:COG1309    82 LRALLRAYLEFLAENPALARLLLAEAAE----LPELRAALRALLRRLRALLAELLRAGG 136
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
11-56 1.12e-11

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 56.65  E-value: 1.12e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1835048639  11 ILSAT-ELFNKQGYNATGIDQIVEHANVATMTLYRNFKSKEKLIESV 56
Cdd:pfam00440   1 ILDAArELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
4-59 6.26e-08

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 49.90  E-value: 6.26e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835048639   4 IKKKDQLILSATELFNKQGYNATGIDQIVEHANVATMTLYRNFKSKEKLIESVLLR 59
Cdd:NF041196    5 IRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE 60
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
 7-52 3.02e-04

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 39.65  E-value: 3.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1835048639   7 KDQLILSATELFNKQGYNATGIDqIVEHA--NVATMTLYrnFKSKEKL 52
Cdd:PRK11552   15 KQQLIAAALAQFGEYGLHATTRD-IAAQAgqNIAAITYY--FGSKEDL 59
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-134 4.24e-16

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 71.08  E-value: 4.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1835048639   1 MKTIKKKDQLILSATELFNKQGYNATGIDQIVEHANVATMTLYRNFKSKEKLIESVLLRREILYFSYLFDNEDLS----- 75
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEdprer 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1835048639  76 IENIVVRHLNWLENYHSNGCLFLKANEEyqnkNEEITKIVKQHKINLLNKLNDILKNEE 134
Cdd:COG1309    82 LRALLRAYLEFLAENPALARLLLAEAAE----LPELRAALRALLRRLRALLAELLRAGG 136
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
11-56 1.12e-11

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 56.65  E-value: 1.12e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1835048639  11 ILSAT-ELFNKQGYNATGIDQIVEHANVATMTLYRNFKSKEKLIESV 56
Cdd:pfam00440   1 ILDAArELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
4-59 6.26e-08

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 49.90  E-value: 6.26e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1835048639   4 IKKKDQLILSATELFNKQGYNATGIDQIVEHANVATMTLYRNFKSKEKLIESVLLR 59
Cdd:NF041196    5 IRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE 60
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
 7-52 3.02e-04

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 39.65  E-value: 3.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1835048639   7 KDQLILSATELFNKQGYNATGIDqIVEHA--NVATMTLYrnFKSKEKL 52
Cdd:PRK11552   15 KQQLIAAALAQFGEYGLHATTRD-IAAQAgqNIAAITYY--FGSKEDL 59
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 2-63 4.83e-04

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 39.14  E-value: 4.83e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1835048639   2 KTIKKKDQLILSAT-ELFNKQGYNATGIDQIVEHANVATMTLYRNFKSKEKLIESVLlrREIL 63
Cdd:PRK15008   14 RAVSAKKKAILSAAlDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVL--RQIL 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH