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Conserved domains on  [gi|1844630412|gb|QJX90396|]
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lipid asymmetry maintenance protein MlaB [Shigella sonnei]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mlaB_1 NF033618
lipid asymmetry maintenance protein MlaB; MlaB belongs to a system that maintains asymmetry in ...
 3-96 6.22e-42

lipid asymmetry maintenance protein MlaB; MlaB belongs to a system that maintains asymmetry in the outer membrane of Gram-negative bacteria, with LPS in the outer leaflet and phospholipids in the inner leaflet. Several components of the system share homology with typical ABC transporters.


:

Pssm-ID: 411237  Cd Length: 94  Bit Score: 132.24  E-value: 6.22e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844630412  3 ESLSWMQTGDTLALSGELDQDVLLPLWEMREEAVKGITCIDLSRVSRVDTGGLALLLHLIDLAKKQGNNVTLQGVNDKVY 82
Cdd:NF033618   1 EALSWEREGDTLALSGELDRDTLLPLWQQREELLAGVTCIDVSGLERVDSAGLALLVHLRAEARQQGRELKISGVSDRLR 80

                         90
                 ....*....|....
gi 1844630412 83 TLAKLYNLPADVLP 96
Cdd:NF033618  81 TLITLYNLPEIILP 94
 
Name Accession Description Interval E-value
mlaB_1 NF033618
lipid asymmetry maintenance protein MlaB; MlaB belongs to a system that maintains asymmetry in ...
 3-96 6.22e-42

lipid asymmetry maintenance protein MlaB; MlaB belongs to a system that maintains asymmetry in the outer membrane of Gram-negative bacteria, with LPS in the outer leaflet and phospholipids in the inner leaflet. Several components of the system share homology with typical ABC transporters.


Pssm-ID: 411237  Cd Length: 94  Bit Score: 132.24  E-value: 6.22e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844630412  3 ESLSWMQTGDTLALSGELDQDVLLPLWEMREEAVKGITCIDLSRVSRVDTGGLALLLHLIDLAKKQGNNVTLQGVNDKVY 82
Cdd:NF033618   1 EALSWEREGDTLALSGELDRDTLLPLWQQREELLAGVTCIDVSGLERVDSAGLALLVHLRAEARQQGRELKISGVSDRLR 80

                         90
                 ....*....|....
gi 1844630412 83 TLAKLYNLPADVLP 96
Cdd:NF033618  81 TLITLYNLPEIILP 94
MlaB COG3113
Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, ...
 1-96 3.96e-22

Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, contains STAS domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442347 [Multi-domain]  Cd Length: 97  Bit Score: 82.22  E-value: 3.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844630412  1 MSESLSWMQTGDTLALSGELDQDVLLPLWEMREEAVK--GITCIDLSRVSRVDTGGLALLLHLIDLAKKQGNNVTLQGVN 78
Cdd:COG3113    1 MSEALLWNAEGGTLRLSGELTRDTVLALWAQLLALLAagGAVEIDLSGVTRVDSAGLALLLELLREARAQGKTLRLTGVP 80

                         90
                 ....*....|....*...
gi 1844630412 79 DKVYTLAKLYNLPaDVLP 96
Cdd:COG3113   81 EQLRTLAALYGLD-ELLP 97
STAS_2 pfam13466
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 14-90 1.72e-08

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 433231 [Multi-domain]  Cd Length: 80  Bit Score: 47.22  E-value: 1.72e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1844630412 14 LALSGELDQDVLLPLWEMREEAVKG--ITCIDLSRVSRVDTGGLALLLHLIDLAKKQGNNVTLQGVNDKVYTLAKLYNL 90
Cdd:pfam13466  1 LSLSGELDADTAPALREALLAALAAgsPVVVDLSGVERVDSAGLALLLALARRARARGKRLVLRGLPPALLRLLRLLGL 79
 
Name Accession Description Interval E-value
mlaB_1 NF033618
lipid asymmetry maintenance protein MlaB; MlaB belongs to a system that maintains asymmetry in ...
 3-96 6.22e-42

lipid asymmetry maintenance protein MlaB; MlaB belongs to a system that maintains asymmetry in the outer membrane of Gram-negative bacteria, with LPS in the outer leaflet and phospholipids in the inner leaflet. Several components of the system share homology with typical ABC transporters.


Pssm-ID: 411237  Cd Length: 94  Bit Score: 132.24  E-value: 6.22e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844630412  3 ESLSWMQTGDTLALSGELDQDVLLPLWEMREEAVKGITCIDLSRVSRVDTGGLALLLHLIDLAKKQGNNVTLQGVNDKVY 82
Cdd:NF033618   1 EALSWEREGDTLALSGELDRDTLLPLWQQREELLAGVTCIDVSGLERVDSAGLALLVHLRAEARQQGRELKISGVSDRLR 80

                         90
                 ....*....|....
gi 1844630412 83 TLAKLYNLPADVLP 96
Cdd:NF033618  81 TLITLYNLPEIILP 94
MlaB COG3113
Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, ...
 1-96 3.96e-22

Binding protein subunit MlaB of the ABC-type intermembrane phospholipid transporter Mla, contains STAS domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442347 [Multi-domain]  Cd Length: 97  Bit Score: 82.22  E-value: 3.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844630412  1 MSESLSWMQTGDTLALSGELDQDVLLPLWEMREEAVK--GITCIDLSRVSRVDTGGLALLLHLIDLAKKQGNNVTLQGVN 78
Cdd:COG3113    1 MSEALLWNAEGGTLRLSGELTRDTVLALWAQLLALLAagGAVEIDLSGVTRVDSAGLALLLELLREARAQGKTLRLTGVP 80

                         90
                 ....*....|....*...
gi 1844630412 79 DKVYTLAKLYNLPaDVLP 96
Cdd:COG3113   81 EQLRTLAALYGLD-ELLP 97
STAS_2 pfam13466
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 14-90 1.72e-08

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C-terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 433231 [Multi-domain]  Cd Length: 80  Bit Score: 47.22  E-value: 1.72e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1844630412 14 LALSGELDQDVLLPLWEMREEAVKG--ITCIDLSRVSRVDTGGLALLLHLIDLAKKQGNNVTLQGVNDKVYTLAKLYNL 90
Cdd:pfam13466  1 LSLSGELDADTAPALREALLAALAAgsPVVVDLSGVERVDSAGLALLLALARRARARGKRLVLRGLPPALLRLLRLLGL 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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