|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10906 |
PRK10906 |
DeoR/GlpR family transcriptional regulator; |
1-252 |
1.62e-179 |
|
DeoR/GlpR family transcriptional regulator;
Pssm-ID: 182827 [Multi-domain] Cd Length: 252 Bit Score: 492.84 E-value: 1.62e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 1 MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPSSSVNTPWHDRKATQTEEKER 80
Cdd:PRK10906 1 MKQTQRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAALPSSSVNTPWHDRKATQTEEKER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 81 IARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEATLDFI 160
Cdd:PRK10906 81 IARKVASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATLDFI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 161 SQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPPPVSVMQ 240
Cdd:PRK10906 161 SQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQLPPASVMQ 240
|
250
....*....|..
gi 1847302091 241 VLTDHHIQLELC 252
Cdd:PRK10906 241 VIEDHHVQLELC 252
|
|
| GlpR |
COG1349 |
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ... |
1-252 |
4.83e-112 |
|
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];
Pssm-ID: 440960 [Multi-domain] Cd Length: 254 Bit Score: 322.08 E-value: 4.83e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 1 MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPSS-SVNTPWHDRKATQTEEKE 79
Cdd:COG1349 1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSaAAEPPFAERETLNAEEKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 80 RIARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEATLDF 159
Cdd:COG1349 81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 160 ISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPPPVSVM 239
Cdd:COG1349 161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240
|
250
....*....|...
gi 1847302091 240 QVLTDHHIQLELC 252
Cdd:COG1349 241 EALEEAGVEVIVA 253
|
|
| DeoRC |
pfam00455 |
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ... |
73-232 |
2.87e-75 |
|
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395365 Cd Length: 160 Bit Score: 225.47 E-value: 2.87e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 73 TQTEEKERIARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGII 152
Cdd:pfam00455 1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 153 GEATLDFISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDA 232
Cdd:pfam00455 81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
|
|
| TranRegGlpR_Halo |
NF041397 |
HTH-type transcriptional regulator GlpR; |
5-235 |
9.31e-56 |
|
HTH-type transcriptional regulator GlpR;
Pssm-ID: 469288 [Multi-domain] Cd Length: 253 Bit Score: 178.95 E-value: 9.31e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 5 QRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGaALPSSSVNT--PWHDRKATQTEEKERIA 82
Cdd:NF041397 5 ERKRKIVELVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGG-AVPVTSVGRerSYGQREVQNLEAKRAIA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 83 RKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLmVKEDFRIILAGGELRSRDGGIIGEATLDFISQ 162
Cdd:NF041397 84 ERAVEEIHDGQVVFFDAGTTTMEVAKRVPTDGSFLAVTNSPLLALEL-AERDGEVKLTGGTLRPRTRALVGPTAESFMER 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1847302091 163 FRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPPP 235
Cdd:NF041397 163 TNFDLLFLGTNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVDLFVTDGALP 235
|
|
| AgaR |
NF040755 |
transcriptional repressor AgaR; |
1-247 |
1.58e-38 |
|
transcriptional repressor AgaR;
Pssm-ID: 468715 [Multi-domain] Cd Length: 256 Bit Score: 134.71 E-value: 1.58e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 1 MKQT-QRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGaALPSSSVNT----PWHDRKATQT 75
Cdd:NF040755 1 MKGTsERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGG-ALINDGFIPgaepSVEDKSRLNT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 76 EEKERIARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEA 155
Cdd:NF040755 80 AVKRLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGDQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 156 TLDFISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPPP 235
Cdd:NF040755 160 AEQSLQNYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIP 239
|
250
....*....|..
gi 1847302091 236 VSVMQVLTDHHI 247
Cdd:NF040755 240 EEYLQGLRKLGV 251
|
|
| HTH_DEOR |
smart00420 |
helix_turn_helix, Deoxyribose operon repressor; |
6-58 |
2.58e-21 |
|
helix_turn_helix, Deoxyribose operon repressor;
Pssm-ID: 197714 [Multi-domain] Cd Length: 53 Bit Score: 83.81 E-value: 2.58e-21
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1847302091 6 RHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAAL 58
Cdd:smart00420 1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAVS 53
|
|
| WHTH_GntR |
cd07377 |
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
21-54 |
3.69e-04 |
|
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 37.81 E-value: 3.69e-04
10 20 30
....*....|....*....|....*....|....
gi 1847302091 21 STEELVEHFSVSPQTIRRDLNELAEQNLILRHHG 54
Cdd:cd07377 27 SERELAEELGVSRTTVREALRELEAEGLVERRPG 60
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10906 |
PRK10906 |
DeoR/GlpR family transcriptional regulator; |
1-252 |
1.62e-179 |
|
DeoR/GlpR family transcriptional regulator;
Pssm-ID: 182827 [Multi-domain] Cd Length: 252 Bit Score: 492.84 E-value: 1.62e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 1 MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPSSSVNTPWHDRKATQTEEKER 80
Cdd:PRK10906 1 MKQTQRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAALPSSSVNTPWHDRKATQTEEKER 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 81 IARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEATLDFI 160
Cdd:PRK10906 81 IARKVASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATLDFI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 161 SQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPPPVSVMQ 240
Cdd:PRK10906 161 SQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQLPPASVMQ 240
|
250
....*....|..
gi 1847302091 241 VLTDHHIQLELC 252
Cdd:PRK10906 241 VIEDHHVQLELC 252
|
|
| GlpR |
COG1349 |
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ... |
1-252 |
4.83e-112 |
|
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];
Pssm-ID: 440960 [Multi-domain] Cd Length: 254 Bit Score: 322.08 E-value: 4.83e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 1 MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPSS-SVNTPWHDRKATQTEEKE 79
Cdd:COG1349 1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSaAAEPPFAERETLNAEEKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 80 RIARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEATLDF 159
Cdd:COG1349 81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEEA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 160 ISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPPPVSVM 239
Cdd:COG1349 161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPELL 240
|
250
....*....|...
gi 1847302091 240 QVLTDHHIQLELC 252
Cdd:COG1349 241 EALEEAGVEVIVA 253
|
|
| DeoRC |
pfam00455 |
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ... |
73-232 |
2.87e-75 |
|
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395365 Cd Length: 160 Bit Score: 225.47 E-value: 2.87e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 73 TQTEEKERIARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGII 152
Cdd:pfam00455 1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 153 GEATLDFISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDA 232
Cdd:pfam00455 81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
|
|
| TranRegGlpR_Halo |
NF041397 |
HTH-type transcriptional regulator GlpR; |
5-235 |
9.31e-56 |
|
HTH-type transcriptional regulator GlpR;
Pssm-ID: 469288 [Multi-domain] Cd Length: 253 Bit Score: 178.95 E-value: 9.31e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 5 QRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGaALPSSSVNT--PWHDRKATQTEEKERIA 82
Cdd:NF041397 5 ERKRKIVELVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGG-AVPVTSVGRerSYGQREVQNLEAKRAIA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 83 RKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLmVKEDFRIILAGGELRSRDGGIIGEATLDFISQ 162
Cdd:NF041397 84 ERAVEEIHDGQVVFFDAGTTTMEVAKRVPTDGSFLAVTNSPLLALEL-AERDGEVKLTGGTLRPRTRALVGPTAESFMER 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1847302091 163 FRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPPP 235
Cdd:NF041397 163 TNFDLLFLGTNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVDLFVTDGALP 235
|
|
| AgaR |
NF040755 |
transcriptional repressor AgaR; |
1-247 |
1.58e-38 |
|
transcriptional repressor AgaR;
Pssm-ID: 468715 [Multi-domain] Cd Length: 256 Bit Score: 134.71 E-value: 1.58e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 1 MKQT-QRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGaALPSSSVNT----PWHDRKATQT 75
Cdd:NF040755 1 MKGTsERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGG-ALINDGFIPgaepSVEDKSRLNT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 76 EEKERIARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEA 155
Cdd:NF040755 80 AVKRLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGDQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 156 TLDFISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPPP 235
Cdd:NF040755 160 AEQSLQNYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIP 239
|
250
....*....|..
gi 1847302091 236 VSVMQVLTDHHI 247
Cdd:NF040755 240 EEYLQGLRKLGV 251
|
|
| PRK09802 |
PRK09802 |
DeoR family transcriptional regulator; |
4-242 |
1.82e-36 |
|
DeoR family transcriptional regulator;
Pssm-ID: 182086 [Multi-domain] Cd Length: 269 Bit Score: 129.97 E-value: 1.82e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 4 TQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPSSsvNTP-----WHDRKATQTEEK 78
Cdd:PRK09802 16 SERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALICDS--TTPsvepsVEDKSALNTAMK 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 79 ERIARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEATLD 158
Cdd:PRK09802 94 RSVAKAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQAEQ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 159 FISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPPPVSV 238
Cdd:PRK09802 174 SLQNYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPADS 253
|
....
gi 1847302091 239 MQVL 242
Cdd:PRK09802 254 LEGL 257
|
|
| srlR |
PRK10434 |
DNA-binding transcriptional repressor; |
1-249 |
1.48e-34 |
|
DNA-binding transcriptional repressor;
Pssm-ID: 182457 [Multi-domain] Cd Length: 256 Bit Score: 124.41 E-value: 1.48e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 1 MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPSSSVNTPWHDRKATQTEEKER 80
Cdd:PRK10434 1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 81 IARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKE-DFRIILAGGELRSRDG---GIIGEAT 156
Cdd:PRK10434 81 IAEAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDnEQTILMPGGTFRKKSAsfhGQLAENA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 157 LdfiSQFRLDFGILGISGIDSDGSLLEFDyhEVRT-KRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPPP 235
Cdd:PRK10434 161 F---EHFTFDKLFIGTDGIDLNAGVTTFN--EVYTvSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGID 235
|
250
....*....|....
gi 1847302091 236 VSVMQVLTDHHIQL 249
Cdd:PRK10434 236 PAFRQALEEKGIEV 249
|
|
| PRK10411 |
PRK10411 |
L-fucose operon activator; |
1-239 |
5.66e-28 |
|
L-fucose operon activator;
Pssm-ID: 236684 [Multi-domain] Cd Length: 240 Bit Score: 106.81 E-value: 5.66e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 1 MKqTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAAL---PSSSVNTPWHDRKATQTEE 77
Cdd:PRK10411 1 MK-AARQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYihrQNQDSGDPFHIRLKSHYAH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 78 KERIARKVAEQIPNGSTLFIDIGTTPEAVAHALLNhSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEATL 157
Cdd:PRK10411 80 KADIAREALAWIEEGMVIALDASSTCWYLARQLPD-INIQVFTNSHPICQELGKRERIQLISSGGTLERKYGCYVNPSLI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 158 DFISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPPPVS 237
Cdd:PRK10411 159 SQLKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQVAT 238
|
..
gi 1847302091 238 VM 239
Cdd:PRK10411 239 SL 240
|
|
| PRK13509 |
PRK13509 |
HTH-type transcriptional regulator UlaR; |
1-143 |
1.18e-23 |
|
HTH-type transcriptional regulator UlaR;
Pssm-ID: 184100 [Multi-domain] Cd Length: 251 Bit Score: 95.46 E-value: 1.18e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 1 MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLI--LRHHGGAALPSSSVNTPWHDRKATQTEEK 78
Cdd:PRK13509 1 MTEAQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLkkVRNGAEAITQQRPRWTPMNIHQAQNHDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1847302091 79 ERIARKVAEQIPNGSTLFIDIGTTPEAVAHALLnHSNLRIVTNNLNVANTLMVKEDFRIILAGGE 143
Cdd:PRK13509 81 VRIAKAASQLCNPGESVVINCGSTAFLLGRELC-GKPVQIITNYLPLANYLIDQEHDSVIIMGGQ 144
|
|
| HTH_DeoR |
pfam08220 |
DeoR-like helix-turn-helix domain; |
6-61 |
2.28e-23 |
|
DeoR-like helix-turn-helix domain;
Pssm-ID: 285436 [Multi-domain] Cd Length: 57 Bit Score: 89.24 E-value: 2.28e-23
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1847302091 6 RHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPSS 61
Cdd:pfam08220 1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVSNSS 56
|
|
| PRK10681 |
PRK10681 |
DNA-binding transcriptional repressor DeoR; Provisional |
1-249 |
5.71e-23 |
|
DNA-binding transcriptional repressor DeoR; Provisional
Pssm-ID: 182644 [Multi-domain] Cd Length: 252 Bit Score: 93.99 E-value: 5.71e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 1 MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILrhhGGAAL--PSSSVNTPWHDRKATQTEEK 78
Cdd:PRK10681 3 TRRDERIGQLLQALKRSDKLHLKDAAALLGVSEMTIRRDLNAHSAPVVLL---GGYIVlePRSASHYLLSDQKSRLVEEK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 79 ERIARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSrDGGIIG----E 154
Cdd:PRK10681 80 RRAAQLAATLVEPNQTLFFDCGTTTPWIIEAIDNELPFTAVCYSLNTFLALQEKPHCRAILCGGEFHA-SNAIFKpldfQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1847302091 155 ATLDFISQfrlDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDAPP 234
Cdd:PRK10681 159 QTLDNICP---DIAFYSAAGVHVSKGATCFNLEELPVKHWAMAMAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSDRCP 235
|
250
....*....|....*
gi 1847302091 235 PVSVMQVLTDHHIQL 249
Cdd:PRK10681 236 DDEFVKYAQAQRIKL 250
|
|
| HTH_DEOR |
smart00420 |
helix_turn_helix, Deoxyribose operon repressor; |
6-58 |
2.58e-21 |
|
helix_turn_helix, Deoxyribose operon repressor;
Pssm-ID: 197714 [Multi-domain] Cd Length: 53 Bit Score: 83.81 E-value: 2.58e-21
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1847302091 6 RHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAAL 58
Cdd:smart00420 1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAVS 53
|
|
| YobV |
COG2378 |
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ... |
1-55 |
3.00e-07 |
|
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];
Pssm-ID: 441945 [Multi-domain] Cd Length: 314 Bit Score: 50.46 E-value: 3.00e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1847302091 1 MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGG 55
Cdd:COG2378 1 MSRLERLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRELGVPIEAERG 55
|
|
| MngR |
COG2188 |
DNA-binding transcriptional regulator, GntR family [Transcription]; |
24-54 |
1.01e-04 |
|
DNA-binding transcriptional regulator, GntR family [Transcription];
Pssm-ID: 441791 [Multi-domain] Cd Length: 238 Bit Score: 42.54 E-value: 1.01e-04
10 20 30
....*....|....*....|....*....|.
gi 1847302091 24 ELVEHFSVSPQTIRRDLNELAEQNLILRHHG 54
Cdd:COG2188 34 ELAEEFGVSRMTVRKALDELVEEGLLERRQG 64
|
|
| ArgR |
COG1438 |
Arginine repressor [Transcription]; |
1-43 |
1.54e-04 |
|
Arginine repressor [Transcription];
Pssm-ID: 441047 Cd Length: 152 Bit Score: 40.89 E-value: 1.54e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1847302091 1 MKQTQRHNGIIELVKQQGYVSTEELVEH-----FSVSPQTIRRDLNEL 43
Cdd:COG1438 1 MKKAARQAKIKEIISEEEIETQEELVELlkeegFNVTQATVSRDLKEL 48
|
|
| HTH_11 |
pfam08279 |
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins. |
10-43 |
2.16e-04 |
|
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
Pssm-ID: 429896 [Multi-domain] Cd Length: 52 Bit Score: 38.18 E-value: 2.16e-04
10 20 30
....*....|....*....|....*....|....
gi 1847302091 10 IIELVKQQGYVSTEELVEHFSVSPQTIRRDLNEL 43
Cdd:pfam08279 4 LQLLLEARGPISGQELAEKLGVSRRTIRRDIKIL 37
|
|
| MntR |
COG1321 |
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription]; |
10-85 |
3.03e-04 |
|
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
Pssm-ID: 440932 [Multi-domain] Cd Length: 135 Bit Score: 39.80 E-value: 3.03e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1847302091 10 IIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILR-HHGGAALpsssvntpwhdrkatqTEEKERIARKV 85
Cdd:COG1321 15 IYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYePYGGITL----------------TEEGRELALRI 75
|
|
| WHTH_GntR |
cd07377 |
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
21-54 |
3.69e-04 |
|
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.
Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 37.81 E-value: 3.69e-04
10 20 30
....*....|....*....|....*....|....
gi 1847302091 21 STEELVEHFSVSPQTIRRDLNELAEQNLILRHHG 54
Cdd:cd07377 27 SERELAEELGVSRTTVREALRELEAEGLVERRPG 60
|
|
| PRK04424 |
PRK04424 |
transcription factor FapR; |
1-44 |
4.07e-04 |
|
transcription factor FapR;
Pssm-ID: 179847 [Multi-domain] Cd Length: 185 Bit Score: 40.19 E-value: 4.07e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 1847302091 1 MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELA 44
Cdd:PRK04424 3 LSKKERQKALQELIEENPFITDEELAEKFGVSIQTIRLDRMELG 46
|
|
| GntR |
pfam00392 |
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ... |
23-57 |
5.79e-04 |
|
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.
Pssm-ID: 306822 [Multi-domain] Cd Length: 64 Bit Score: 37.21 E-value: 5.79e-04
10 20 30
....*....|....*....|....*....|....*
gi 1847302091 23 EELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAA 57
Cdd:pfam00392 28 RELAAEFGVSRTTVREALRRLEAEGLVERRQGRGT 62
|
|
| COG4742 |
COG4742 |
Predicted transcriptional regulator, contains HTH domain [Transcription]; |
21-55 |
2.70e-03 |
|
Predicted transcriptional regulator, contains HTH domain [Transcription];
Pssm-ID: 443776 [Multi-domain] Cd Length: 267 Bit Score: 38.34 E-value: 2.70e-03
10 20 30
....*....|....*....|....*....|....*
gi 1847302091 21 STEELVEHFSVSPQTIRRDLNELAEQNLILRHHGG 55
Cdd:COG4742 31 TRSELAESLDVSRSTILRQLKELEERGLIERDDGE 65
|
|
| HTH_GNTR |
smart00345 |
helix_turn_helix gluconate operon transcriptional repressor; |
21-56 |
5.06e-03 |
|
helix_turn_helix gluconate operon transcriptional repressor;
Pssm-ID: 197669 [Multi-domain] Cd Length: 60 Bit Score: 34.47 E-value: 5.06e-03
10 20 30
....*....|....*....|....*....|....*.
gi 1847302091 21 STEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGA 56
Cdd:smart00345 22 SERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSG 57
|
|
| BglG |
COG3711 |
Transcriptional antiterminator [Transcription]; |
10-54 |
7.06e-03 |
|
Transcriptional antiterminator [Transcription];
Pssm-ID: 442925 [Multi-domain] Cd Length: 618 Bit Score: 37.53 E-value: 7.06e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 1847302091 10 IIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELaeqNLILRHHG 54
Cdd:COG3711 2 LKILLKNNNVVTAKELAKKLNVSERTIRYDIKKI---NEWLKKNG 43
|
|
| |
