|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
5-1298 |
0e+00 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 2888.21 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 5 QKITFSSLFERLDGLMLRDKSRFARRLHGVKKVKNPDAQQAILQEMAQEIEQAAGRVLLREAARPAIAYPENLPVSQKKQ 84
Cdd:PRK11131 1 MKLTLTALQQQLDELMLRDRQRLSRRLHGAKKIKNPDAQQAIFQEIAKEIAQAAQRVLLREAARPEITYPENLPVSQKKQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 85 EILEAVRDHQVVIVAGETGSGKTTQLPKICMELGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGYKVRFSDHV 164
Cdd:PRK11131 81 DILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVKGLIGHTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 165 SDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATIDPERFSRHFNNA 244
Cdd:PRK11131 161 SDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 245 PIIEVSGRTYPVEVRYRPIVEDADDTERDQLQAIFDAVDELGRESPGDILIFMSGEREIRDTADALNKLNLRHTEVLPLY 324
Cdd:PRK11131 241 PIIEVSGRTYPVEVRYRPIVEEADDTERDQLQAIFDAVDELGREGPGDILIFMSGEREIRDTADALNKLNLRHTEILPLY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 325 ARLSNSEQNRVFQAHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSFRTKVQRLPIEPVSQASANQRKGRCGRVS 404
Cdd:PRK11131 321 ARLSNSEQNRVFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 405 EGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEQQTAY 484
Cdd:PRK11131 401 EGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEQASAY 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 485 KLTPMGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERPMDKQQASDEKHRRFHDKESDFLAFVNLWNY 564
Cdd:PRK11131 481 KLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADKESDFLAFVNLWNY 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 565 LGEQQKALSSNQFRRQCRVDFLNYLRVREWQDIYTQLRQVVKELGLPVNSEPAEYREIHTALLTGLLSHIGMKDADKQEF 644
Cdd:PRK11131 561 LQEQQKALSSNQFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGLLSHIGMKDAEKQEY 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 645 TGARNARFSIFPGSGLFKKPPKWTMVAELVETSRLWGRIAARIEPEWVEPVAQHLIKRSYSEPHWERGQGAVMATEKVTV 724
Cdd:PRK11131 641 TGARNARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIEPEWIEPLAQHLIKRSYSEPHWEKAQGAVMATEKVTL 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 725 YGLPIVAARKVNYSQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRNEIEELEHKSRRRDILVDDETLFEFYDQRIS 804
Cdd:PRK11131 721 YGLPIVAARKVNYGQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRAEVEELEHKSRRRDILVDDETLFEFYDQRIG 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 805 HDVISARHFDKWWKQASRETPDLLNFEKSMLIKEGAEQVSKLDYPNFWHQGNLKLRLTYQFEPGADADGVTVHIPLPLLN 884
Cdd:PRK11131 801 HDVVSARHFDSWWKKASRETPELLNFEKSMLIKEGAEKVSKLDYPNFWHQGNLKLRLSYQFEPGADADGVTVHIPLPLLN 880
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 885 QVEEAGFEWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGRATPLELPLLDSLERELRRMTGVTIDREAWQWDQ 964
Cdd:PRK11131 881 QVEESGFDWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGRVTPLELPLLDSLERELRRMTGVTVDREDWQWDQ 960
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 965 VPDHLKITFRVVDEKNKKLQEGRSLQDLKDALKGKVQETLSAVADDGIEQSGLHIWSFGRLPESYEQKRGNYKVKAWPAL 1044
Cdd:PRK11131 961 VPDHLKITFRVVDDKNKKLAEGKDLQELKDALKGKVQETLSAVADDGIEQSGLHIWSFGELPESYEQKRGGYKVKAYPAL 1040
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 1045 VDERDSVAIKLFDNPLEQQQEMWRGLRRLLLLNIPSPIKYLHEKLPNKAKLGLYFNPYGKVLDLIDDCIACGVDKLIDEA 1124
Cdd:PRK11131 1041 VDEKDSVAIKLFDTELEQQQAMWQGLRRLLLLNIPSPIKYLHEKLPNKAKLGLYFNPYGKVLDLIDDCIACGVDKLIDEN 1120
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 1125 GGPVWSEEGFAALHEKVRAELNETVVDIAKQVEQILTAVFNVNKRLKGRVDMTMALGLSDIKSQMSGLVYRGFVTGNGFR 1204
Cdd:PRK11131 1121 GGPVWTEEGFAALHEKVRAELNDTVVDIAKQVEQILTAVFNINKRLKGRVDMTMALALSDIKAQMGGLVYRGFVTGNGWK 1200
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 1205 RLGDTLRYLQAIEKRLEKMAIDPHRDRAQMLKVESIQQAWQQWLNKLPPQRRQDDDVQEIRWMIEELRVSLFAQQLGTPY 1284
Cdd:PRK11131 1201 RLGDTLRYLQAIEKRLEKLAVDPHRDRAQMLKVESVQQAWQQWLNKLPPARREDEDVKEIRWMIEELRVSYFAQQLGTPY 1280
|
1290
....*....|....
gi 1850347661 1285 PISDKRVLQAMEQI 1298
Cdd:PRK11131 1281 PISDKRILQAMEQI 1294
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
12-1297 |
0e+00 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 2255.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 12 LFERLDGLMLRDKSRFARRLHGVKKVKNPDAQQAILQEMAQEIEQAAGRVLLREAARPAIAYPENLPVSQKKQEILEAVR 91
Cdd:TIGR01967 1 LAEDLDHTMIRDRHRLRRRLHKLRKDHDQDRAIAALAKFRERIDAACDKVEARRQAVPEIRYPDNLPVSAKREDIAEAIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 92 DHQVVIVAGETGSGKTTQLPKICMELGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGYKVRFSDHVSDNTMVK 171
Cdd:TIGR01967 81 ENQVVIIAGETGSGKTTQLPKICLELGRGSHGLIGHTQPRRLAARTVAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 172 LMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSG 251
Cdd:TIGR01967 161 LMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 252 RTYPVEVRYRPIVEDADDTERDQLQAIFDAVDELGRESPGDILIFMSGEREIRDTADALNKLNLRHTEVLPLYARLSNSE 331
Cdd:TIGR01967 241 RTYPVEVRYRPLVEEQEDDDLDQLEAILDAVDELFAEGPGDILIFLPGEREIRDAAEILRKRNLRHTEILPLYARLSNKE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 332 QNRVFQAHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSFRTKVQRLPIEPVSQASANQRKGRCGRVSEGICIRL 411
Cdd:TIGR01967 321 QQRVFQPHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 412 YSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEQqtAYKLTPMGR 491
Cdd:TIGR01967 401 YSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEA--EPQLTPIGR 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 492 QLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERPMDKQQASDEKHRRFHDKESDFLAFVNLWNYLGEQQKA 571
Cdd:TIGR01967 479 QLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAHARFKDPRSDFLSRVNLWRHIEEQRQA 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 572 LSSNQFRRQCRVDFLNYLRVREWQDIYTQLRQVVKELGLPVNSEPAEYREIHTALLTGLLSHIGMKDAdKQEFTGARNAR 651
Cdd:TIGR01967 559 LSANQFRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLSQIGMKDE-KHEYDGARGRK 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 652 FSIFPGSGLFKKPPKWTMVAELVETSRLWGRIAARIEPEWVEPVAQHLIKRSYSEPHWERGQGAVMATEKVTVYGLPIVA 731
Cdd:TIGR01967 638 FHIFPGSPLFKKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAGHLIKKNYFEPHWEKKRGQVMAYEKVTLYGLTLVA 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 732 ARKVNYSQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRNEIEELEHKSRRRDILVDDETLFEFYDQRISHDVISAR 811
Cdd:TIGR01967 718 RRSVPYGPIDPADAREMFIRHALVEGEWQTRAAFFQANRALLEEVEELEHKARRRDILVDEQTLFDFYDGRLPEDINNAR 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 812 HFDKWWKQASRETPDLLNFEKSMLIKEGAEQVSKLDYPNFWHQGNLKLRLTYQFEPGADADGVTVHIPLPLLNQVEEAGF 891
Cdd:TIGR01967 798 HFDSWWKKASRKQPDLLDFPKEVLFQRRANVISAAQFPDHWHKGDLRLALSYHFEPGHGDDGVTVHIPLPLLNQLDTEDF 877
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 892 EWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGRATPLELPLLDSLERELRRMTGVTIDREAWQWDQVPDHLKI 971
Cdd:TIGR01967 878 DWLVPGLREEKVVALIKSLPKALRRNFVPAPDFAKACLARLPPNQGPLTDALARELRRMTGERVNPEDWDWEQLPDHLQM 957
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 972 TFRVVDEKNKKLQEGRSLQDLKDALKGKVQETLSAVADDGIEQSGLHIWSFGRLPESYEQKRGNYKVKAWPALVDERDSV 1051
Cdd:TIGR01967 958 NFRIVDDKGKVLAQGRDLALLKERLAGDVRAALSAVADVGIEKSGLTNWSFGPLPERMEQKTGNYKVTAYPALVDDGGSV 1037
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 1052 AIKLFDNPLEQQQEMWRGLRRLLLLNIPSPIKYLHEKLPNKAKLGLYFNPYGKVLDLIDDCIACGVDKLIDEAGGPVWSE 1131
Cdd:TIGR01967 1038 AIKLFDTQAEAEAAHRAGLRRLLLLQIPSPVKMLQGKLPNKAKLALYYNPLGRVEVLVDDILHAAVDRLIFENGGQVRTQ 1117
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 1132 EGFAALHEKVRAELNETVVDIAKQVEQILTAVFNVNKRLKGRVDMTMALGLSDIKSQMSGLVYRGFVTGNGFRRLGDTLR 1211
Cdd:TIGR01967 1118 ADFAALLAQVRAELAPEVERIAKQLEEILVLFGNIRKRLKGKIDPTQAKALSDIKAQLDKLVYQGFVRTTGPQRLSHLPR 1197
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 1212 YLQAIEKRLEKMAIDPHRDRAQMLKVESIQQAWQQWLNKLPPQRRQDDDVQEIRWMIEELRVSLFAQQLGTPYPISDKRV 1291
Cdd:TIGR01967 1198 YLKAMELRLEKLRVDPGRDRERQAEISNVQEAYDARLAKLPHERRLPAALVEIRWMIEEYRVSLFAQQLGTAYPISDKRI 1277
|
....*.
gi 1850347661 1292 LQAMEQ 1297
Cdd:TIGR01967 1278 LKYYRQ 1283
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
69-920 |
0e+00 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 1135.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 69 PAIAYPENLPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICMELGRGVKGLIGHTQPRRLAARTVANRIAEELQT 148
Cdd:COG1643 2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRIGMLEPRRLAARAAAERMAEELGE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 149 EPGGCIGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPR-RPDLKIII 227
Cdd:COG1643 82 PVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLKLLV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 228 TSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPIVEDaddtERDQLQAIFDAVDELGRESPGDILIFMSGEREIRDTA 307
Cdd:COG1643 162 MSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPLPAD----ERDLEDAVADAVREALAEEPGDILVFLPGEREIRRTA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 308 DALNKLNLRHTEVLPLYARLSNSEQNRVFQ--AHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSFRTKVQRLPI 385
Cdd:COG1643 238 EALRGRLPPDTEILPLYGRLSAAEQDRAFApaPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 386 EPVSQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDG 465
Cdd:COG1643 318 ERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADA 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 466 VRLLEELGAITTDeqqtaYKLTPMGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRerpmdKQQASdekh 545
Cdd:COG1643 398 RALLQELGALDAD-----GRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR-----RGAAG---- 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 546 rrfhdkeSDFLAFVNLWNYLGEQQKAlssnqfrrqcrvdFLNYLRVREWQDIYTQLRQVVKElglPVNSEPAEYREIHTA 625
Cdd:COG1643 464 -------SDLLARLNLWRRLREQQRE-------------FLSYLRLREWRDLARQLRRLLGE---GANEEPADYEAIGLL 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 626 LLTGLLSHIGMKDADKQEFTGARNARFSIFPGSGLFKKPpkWTMVAELVETSR-LWGRIAARIEPEWVEPVAQHLIKRsY 704
Cdd:COG1643 521 LALAYPDRIARRRGEGGRYLLARGRGAALFPGSPLAKKE--WLVAAELVGGAAeARIRLAAPIDPEWLEELAAHLIKR-Y 597
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 705 SEPHWERGQGAVMATEKVTVYGLPIVAARKvnySQIDPALCRELFIRHALVEGDwqTRHAFFRENLKLRNEIEELEHKS- 783
Cdd:COG1643 598 SEPHWDKKRGRVVARERVRLGALVLVSRPL---PGPDPEAAREALLRALRREGL--DLLPWSKAARQLRARVEFLERKLg 672
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 784 -RRRDilVDDETLfefydqrishdvisARHFDKWWKQASRETPDLLNFEKSMLIKE-----GAEQVSKLD--YPNFWHQ- 854
Cdd:COG1643 673 eRWPD--VSDEAL--------------LATLEDWLAPYLTGVRSLKDLKRLDLLAAlrallPWEQQQRLDelAPTHLTVp 736
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 855 GNLKLRLTY-------------QF----EPGAdADGvTVHIPLPLLNQV-EEAGFEWQIPGLRRELVIALIKSLPKPVRR 916
Cdd:COG1643 737 SGSRLPLDYsadgppvavrlqeLFglaeTPGV-ADG-RVPVPLHLLSPAgRPLQVTWDLPGFWRGSYAEVRKELRGRYPK 814
|
....
gi 1850347661 917 NFVP 920
Cdd:COG1643 815 HPWP 818
|
|
| DUF3418 |
pfam11898 |
Domain of unknown function (DUF3418); This presumed domain is functionally uncharacterized. ... |
713-1295 |
0e+00 |
|
Domain of unknown function (DUF3418); This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is typically between 582 to 594 amino acids in length. This domain is found associated with pfam07717, pfam00271, pfam04408.
Pssm-ID: 463389 Cd Length: 587 Bit Score: 891.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 713 QGAVMATEKVTVYGLPIVAARKVNYSQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRNEIEELEHKSRRRDILVDD 792
Cdd:pfam11898 2 RGAVMAYERVTLYGLPIVARRRVNYGRIDPEEAREIFIRHALVEGEWRTRHTFFAHNRKLLEEVEELEHKARRRDILVDD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 793 ETLFEFYDQRISHDVISARHFDKWWKQASRETPDLLNFEKSMLIKEGAEQVSKLDYPNFWHQGNLKLRLTYQFEPGADAD 872
Cdd:pfam11898 82 ETLFDFYDARLPADVVSGRHFDKWWKKARREDPDLLDLTREDLLRHEADAVTEEDFPDTWGLGGLRLPLSYRFEPGAEDD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 873 GVTVHIPLPLLNQVEEAGFEWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGR---ATPLELPLLDSLERELRR 949
Cdd:pfam11898 162 GVTVTVPLALLNQVSPERFDWLVPGLLEEKVTALIKSLPKALRRNFVPAPDFARAALARlerEPPGDGPLLDALARALRR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 950 MTGVTIDREAWQWDQVPDHLKITFRVVDEKNKKLQEGRSLQDLKDALKGKVQETLSAVADDGIEQSGLHIWSFGRLPESY 1029
Cdd:pfam11898 242 LTGVRVPPDDWDLDALPPHLRMNFRVVDDRGKVLAEGRDLAALKARLAGQARAAFAAAAAASLERTGLTSWDFGDLPETV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 1030 EQKRGNYKVKAWPALVDERDSVAIKLFDNPLEQQQEMWRGLRRLLLLNIPSPIKYLHEKLPNKAKLGLYFNPYGKVLDLI 1109
Cdd:pfam11898 322 ELKRGGQEVTGYPALVDEGDSVALRLFDTPAEAAAAHRAGVRRLLLLALPSPVKYLEKNLPNLQKLALAYNPLGSVEALV 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 1110 DDCIACGVDKLIDEAGGPVWSEEGFAALHEKVRAELNETVVDIAKQVEQILTAVFNVNKRLKGRVDMTMALGLSDIKSQM 1189
Cdd:pfam11898 402 DDLIAAALDRLFLEPVPLPRDEAAFEALLEEVRARLPDTAQEVARLVEEILAAYQALRKRLKGKKSLALAAALADIRAQL 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 1190 SGLVYRGFVTGNGFRRLGDTLRYLQAIEKRLEKMAIDPHRDRAQMLKVESIQQAWQQWLNKLPPQRRQDDDVQEIRWMIE 1269
Cdd:pfam11898 482 DRLVPPGFVAATPWERLAHLPRYLKAIELRLEKLPADPARDRQRMAEVAPLEQRYQALLAKLPAGRPDPEELEEFRWMLE 561
|
570 580
....*....|....*....|....*.
gi 1850347661 1270 ELRVSLFAQQLGTPYPISDKRVLQAM 1295
Cdd:pfam11898 562 ELRVSLFAQELGTPYPVSEKRLEKAW 587
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
77-249 |
2.62e-116 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 359.85 E-value: 2.62e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICMELGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGY 156
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGAVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 157 KVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATIDPER 236
Cdd:cd17989 81 KVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAER 160
|
170
....*....|...
gi 1850347661 237 FSRHFNNAPIIEV 249
Cdd:cd17989 161 FSRHFNNAPIIEV 173
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
77-525 |
9.12e-99 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 334.59 E-value: 9.12e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPkicMEL--GRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCI 154
Cdd:PRK11664 4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLP---LQLlqHGGINGKIIMLEPRRLAARNVAQRLAEQLGEKPGETV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 155 GYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLREL---LprRPDLKIIITSAT 231
Cdd:PRK11664 81 GYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVqqgL--RDDLKLLIMSAT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 232 IDPERFSRHFNNAPIIEVSGRTYPVEVRYRPIvedaddTERDQL-QAIFDAVDELGRESPGDILIFMSGEREIRDTADAL 310
Cdd:PRK11664 159 LDNDRLQQLLPDAPVIVSEGRSFPVERRYQPL------PAHQRFdEAVARATAELLRQESGSLLLFLPGVGEIQRVQEQL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 311 NKLNLRHTEVLPLYARLSNSEQNRVFQ-AHSGRR-IVLATNVAETSLTVPGIKYVIDPGTARISRYSFRTKVQRLPIEPV 388
Cdd:PRK11664 233 ASRVASDVLLCPLYGALSLAEQQKAILpAPAGRRkVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRI 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 389 SQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRL 468
Cdd:PRK11664 313 SQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRL 392
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1850347661 469 LEELGAIttDEQQtayKLTPMGRQLSQLPVDPRLARMVLEAQKHGcvrEAMIITSAL 525
Cdd:PRK11664 393 LQQLGAL--DGQG---RLTARGRKMAALGNDPRLAAMLVAAKEDD---EAALATAAK 441
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
93-249 |
2.66e-78 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 254.69 E-value: 2.66e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 93 HQVVIVAGETGSGKTTQLPKICME--LGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGYKVRFSDHVSDNTMV 170
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEdgLAKGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1850347661 171 KLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATIDPERFSRHFNNAPIIEV 249
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
77-247 |
3.86e-63 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 212.60 E-value: 3.86e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICMELGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGY 156
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 157 KVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRR-----PDLKIIITSAT 231
Cdd:cd17978 81 SVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVIIMSAT 160
|
170
....*....|....*.
gi 1850347661 232 IDPERFSRHFNNAPII 247
Cdd:cd17978 161 LDADLFSEYFNGAPVL 176
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
77-249 |
2.94e-62 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 209.63 E-value: 2.94e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICMELGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGY 156
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 157 KVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATIDPER 236
Cdd:cd17983 81 AIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDADK 160
|
170
....*....|...
gi 1850347661 237 FSRHFNNAPIIEV 249
Cdd:cd17983 161 FADFFGNVPIFTI 173
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
254-412 |
4.19e-62 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 209.31 E-value: 4.19e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 254 YPVEVRYRPIVE-----DADDTERDQLQAIFDAVDEL-GRESPGDILIFMSGEREIRDTADALNKL----NLRHTEVLPL 323
Cdd:cd18791 1 FPVEVYYLEDILellgiSSEKEDPDYVDAAVRLILQIhRTEEPGDILVFLPGQEEIERLCELLREEllspDLGKLLVLPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 324 YARLSNSEQNRVFQAHSG--RRIVLATNVAETSLTVPGIKYVIDPGTARISRYSFRTKVQRLPIEPVSQASANQRKGRCG 401
Cdd:cd18791 81 HSSLPPEEQQRVFEPPPPgvRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAG 160
|
170
....*....|.
gi 1850347661 402 RVSEGICIRLY 412
Cdd:cd18791 161 RTRPGKCYRLY 171
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
75-249 |
7.12e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 206.18 E-value: 7.12e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 75 ENLPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICMELGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCI 154
Cdd:cd17971 4 ESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLGQEV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 155 GYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATIDP 234
Cdd:cd17971 84 GYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSATLDA 163
|
170
....*....|....*
gi 1850347661 235 ERFSRHFNNAPIIEV 249
Cdd:cd17971 164 VKFSQYFYEAPIFTI 178
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
77-249 |
4.43e-60 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 204.19 E-value: 4.43e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICME--LGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCI 154
Cdd:cd17973 13 LPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDdeLPHQPKKLVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 155 GYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATIDP 234
Cdd:cd17973 93 GYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLKLIVMSATLDA 172
|
170
....*....|....*
gi 1850347661 235 ERFSRHFNNAPIIEV 249
Cdd:cd17973 173 GKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
77-249 |
1.15e-56 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 193.87 E-value: 1.15e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICMELGRGVKGL-IGHTQPRRLAARTVANRIAEELQTEPGGCIG 155
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGkIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 156 YKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATIDPE 235
Cdd:cd17974 81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAE 160
|
170
....*....|....
gi 1850347661 236 RFSRHFNNAPIIEV 249
Cdd:cd17974 161 KFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
77-249 |
2.28e-56 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 193.72 E-value: 2.28e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICMELGRGVK-----GLIGHTQPRRLAARTVANRIAEELqTEPG 151
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPesdnpGMIGITQPRRVAAVSMAKRVAEEL-NVFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 152 GCIGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPD--------- 222
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvk 159
|
170 180 190
....*....|....*....|....*....|..
gi 1850347661 223 -LKIIITSATIDPERFS---RHFNNAP-IIEV 249
Cdd:cd17982 160 pLKLVIMSATLRVEDFTenkLLFPRPPpVIKV 191
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
77-249 |
1.19e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 185.44 E-value: 1.19e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICMELGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGY 156
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 157 KVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLP-----RRPDLKIIITSAT 231
Cdd:cd17984 81 QVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQekspnRKEHLKVVVMSAT 160
|
170
....*....|....*...
gi 1850347661 232 IDPERFSRHFNNAPIIEV 249
Cdd:cd17984 161 LELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
77-249 |
7.92e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 182.64 E-value: 7.92e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICMELGRGVkglIGHTQPRRLAARTVANRIAEELQTEPGGCIGY 156
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH---IACTQPRRIACISLAKRVAFESLNQYGSKVAY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 157 KVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATIDPER 236
Cdd:cd17979 78 QIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIEL 157
|
170
....*....|...
gi 1850347661 237 FSRHFNNAPIIEV 249
Cdd:cd17979 158 FSGYFEGAPVVQV 170
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
77-242 |
1.35e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 179.59 E-value: 1.35e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICMELGRGVKG-LIGHTQPRRLAARTVANRIAEELQTEPGGCIG 155
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGrVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 156 YKVRFSDHVSD-NTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATIDP 234
Cdd:cd17980 81 YCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDA 160
|
....*...
gi 1850347661 235 ERFSRHFN 242
Cdd:cd17980 161 EKFRDFFN 168
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
77-249 |
4.03e-48 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 169.71 E-value: 4.03e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICME-----LGRGVKGLIGHTQPRRLAARTVANRIAEELQTE-- 149
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllnGGTAQKCNIVCTQPRRISAMSLATRVCEELGCEsg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 150 PGG----CiGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKI 225
Cdd:cd17975 81 PGGknslC-GYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHL 159
|
170 180
....*....|....*....|....
gi 1850347661 226 IITSATIDPERFSRHFNNAPIIEV 249
Cdd:cd17975 160 ILMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
77-249 |
8.85e-44 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 156.91 E-value: 8.85e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICME--LGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCI 154
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDdcYANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 155 GYKVRFSDHVSDNTMVKLMTDGILLAEIQQ-DRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATID 233
Cdd:cd17987 81 GYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAALD 160
|
170
....*....|....*.
gi 1850347661 234 PERFSRHFNNAPIIEV 249
Cdd:cd17987 161 VNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
77-249 |
1.99e-43 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 156.16 E-value: 1.99e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKIC----MELGRGVKGLIGHTQPRRLAARTVANRIAEEL--QTEP 150
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFIlddaIERGKGSSCRIVCTQPRRISAISVAERVAAERaeSCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 151 GGCIGYKVRFSDHVSDN-TMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITS 229
Cdd:cd17981 81 GNSTGYQIRLESRKPRKqGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 1850347661 230 ATIDPERFSRHFNNAPIIEV 249
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
77-249 |
1.81e-42 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 153.26 E-value: 1.81e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICMELGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGY 156
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGKIIVLEPRRVAARAAARRLATLLGEAPGETVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 157 KVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLP-RRPDLKIIITSATIDPE 235
Cdd:cd17990 81 RVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSATLDGD 160
|
170
....*....|....
gi 1850347661 236 RFSRHFNNAPIIEV 249
Cdd:cd17990 161 GLAALLPEAPVVES 174
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
77-249 |
3.39e-41 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 149.56 E-value: 3.39e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICME----LGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGG 152
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEdyvlRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 153 CIGYKVRF-SDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSAT 231
Cdd:cd17976 81 NVGYQVRLeSRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160
|
170
....*....|....*...
gi 1850347661 232 IDPERFSRHFNNAPIIEV 249
Cdd:cd17976 161 GDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
77-249 |
1.60e-39 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 144.98 E-value: 1.60e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICME--LGRGVKGL--IGHTQPRRLAARTVANRIAEELQTEPGG 152
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDnsLQGPPLPVanIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 153 CIGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATI 232
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160
|
170
....*....|....*..
gi 1850347661 233 DPERFSRHFNNAPIIEV 249
Cdd:cd17985 161 NAELFSDYFNSCPVIHI 177
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
77-249 |
2.48e-38 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 141.49 E-value: 2.48e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICME--LGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCI 154
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDhyYKRGKYCNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 155 GYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPD-LKIIITSATID 233
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILMSATIS 160
|
170 180
....*....|....*....|
gi 1850347661 234 PERFSRHF----NNAPIIEV 249
Cdd:cd17988 161 CKEFADYFttpnNPAYVFEV 180
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
75-249 |
3.29e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 143.05 E-value: 3.29e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 75 ENLPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICMEL----GRGVKGLIGHTQPRRLAARTVANRIAEELQTEP 150
Cdd:cd17972 57 ELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDfiqnDRAAECNIVVTQPRRISAVSVAERVAFERGEEV 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 151 GGCIGYKVRFsDHVSDNTMVKLM--TDGILLAEIQQDrlLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIIT 228
Cdd:cd17972 137 GKSCGYSVRF-ESVLPRPHASILfcTVGVLLRKLEAG--IRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILM 213
|
170 180
....*....|....*....|.
gi 1850347661 229 SATIDPERFSRHFNNAPIIEV 249
Cdd:cd17972 214 SATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
77-249 |
1.11e-32 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 125.32 E-value: 1.11e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQVVIVAGETGSGKTTQLPKICMEL---GRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGC 153
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYclsAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 154 IGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATID 233
Cdd:cd17977 81 VGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPHL 160
|
170
....*....|....*.
gi 1850347661 234 PERFSRHFNNAPIIEV 249
Cdd:cd17977 161 SSKLLSYYGNVPLIEV 176
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
77-249 |
1.17e-30 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 119.62 E-value: 1.17e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 77 LPVSQKKQEILEAVRDHQ-VVIVAGETGSGKTTQLPKICME--LGRGV-KGLIGHTQPRRLAARTVANRIAEELQTEPGG 152
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAEfaLSRGFqKGQVTVTQPHPLAARSLALRVADEMDLNLGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 153 CIGYKVRFSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLPRRPDLKIIITSATI 232
Cdd:cd17986 81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSPA 160
|
170
....*....|....*..
gi 1850347661 233 DPERFSRHFNNAPIIEV 249
Cdd:cd17986 161 LEPKLRAFWGNPPVVHV 177
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
471-559 |
1.14e-26 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 104.66 E-value: 1.14e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 471 ELGAITTDEQqtaykLTPMGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERpmDKQQASDEKHRRFHD 550
Cdd:smart00847 1 ELGALDDDGR-----LTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPK--EKREDADAARRRFAD 73
|
....*....
gi 1850347661 551 KESDFLAFV 559
Cdd:smart00847 74 PESDHLTLL 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
83-261 |
3.25e-23 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 98.72 E-value: 3.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 83 KQEILEAVRDHQVVIVAGETGSGKTTQLPKICME-LGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGY----- 156
Cdd:smart00487 14 KEAIEALLSGLRDVILAAPTGSGKTLAALLPALEaLKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLyggds 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 157 -KVRFSDHVSDNTMVKLMTDGILLAEIQQDRL-LMQYDTIIIDEAHERS--LNIDFLLGYLRELlprRPDLKIIITSATI 232
Cdd:smart00487 94 kREQLRKLESGKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLdgGFGDQLEKLLKLL---PKNVQLLLLSATP 170
|
170 180 190
....*....|....*....|....*....|.
gi 1850347661 233 --DPERFSRHFNNAPIIEVSGRTYPVEVRYR 261
Cdd:smart00487 171 peEIENLLELFLNDPVFIDVGFTPLEPIEQF 201
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
466-558 |
2.42e-21 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 89.99 E-value: 2.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 466 VRLLEELGAITTDEQqtaykLTPMGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERPMDKQQASDEKH 545
Cdd:pfam04408 2 LELLYYLGALDEDGE-----LTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKA 76
|
90 100
....*....|....*....|....*...
gi 1850347661 546 RR---------------FHDKESDFLAF 558
Cdd:pfam04408 77 ARrrrraadekarakfaRLDLEGDHLTL 104
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
622-699 |
7.54e-16 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 73.83 E-value: 7.54e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 622 IHTALLTGLLSHIGMKDADKQEFTGAR-NARFSIFPGSGLF---KKPPKWTMVAELVETSRLWGRIAARIEPEWVEPVAQ 697
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLSdNQRVFIHPSSVLFnekTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
..
gi 1850347661 698 HL 699
Cdd:pfam07717 81 HI 82
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
78-415 |
7.37e-14 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 76.17 E-value: 7.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 78 PVSQkkQEILEAVRDHQVVIVAGETGSGKTTQLPKICM---ELGRGVKGL-----------IGHTQPR----RLAARTVA 139
Cdd:PHA02653 166 PDVQ--LKIFEAWISRKPVVLTGGTGVGKTSQVPKLLLwfnYLFGGFDNLdkidpnfierpIVLSLPRvalvRLHSITLL 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 140 NRIA-EELQTEPggcigYKVRFSDHVSDNTMVKLMTDGILLAeiqQDRL----LMQYDTIIIDEAHERSLNIDFLLGYLR 214
Cdd:PHA02653 244 KSLGfDEIDGSP-----ISLKYGSIPDELINTNPKPYGLVFS---THKLtlnkLFDYGTVIIDEVHEHDQIGDIIIAVAR 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 215 ELLPRRPDLkiIITSATI--DPERFSRHFNNAPIIEVSGRT-YPV-EV----RYRPI--VEDADDTERDQLQAIFDAVDE 284
Cdd:PHA02653 316 KHIDKIRSL--FLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPIsEVyvknKYNPKnkRAYIEEEKKNIVTALKKYTPP 393
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 285 LGREspgdILIFMSGEREIRDTADALNKLN------LRHTEVLPLYARLSNseqnrvFQAHSGRRIVLATNVAETSLTVP 358
Cdd:PHA02653 394 KGSS----GIVFVASVSQCEEYKKYLEKRLpiydfyIIHGKVPNIDEILEK------VYSSKNPSIIISTPYLESSVTIR 463
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1850347661 359 GIKYVIDpgTARISRYSFRTKVQRLpiepVSQASANQRKGRCGRVSEGICIRLYSED 415
Cdd:PHA02653 464 NATHVYD--TGRVYVPEPFGGKEMF----ISKSMRTQRKGRVGRVSPGTYVYFYDLD 514
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
311-402 |
1.14e-10 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 58.76 E-value: 1.14e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 311 NKLNLRHTEVLPLYARLSNSEQNRVFQA--HSGRRIVLATNVAETSLTVPGIKYVIDPGTarisrysfrtkvqrlpiePV 388
Cdd:smart00490 5 ELLKELGIKVARLHGGLSQEEREEILDKfnNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------PW 66
|
90
....*....|....
gi 1850347661 389 SQASANQRKGRCGR 402
Cdd:smart00490 67 SPASYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
282-403 |
8.59e-10 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 57.22 E-value: 8.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 282 VDELGRESPGDILIFMSGereiRDTADALNKLNLRHTEVLPLYARLSNSEQNRVFQA--HSGRRIVLATNVAETSLTVPG 359
Cdd:pfam00271 7 LELLKKERGGKVLIFSQT----KKTLEAELLLEKEGIKVARLHGDLSQEEREEILEDfrKGKIDVLVATDVAERGLDLPD 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1850347661 360 IKYVIDpgtarisrYSFrtkvqrlpiePVSQASANQRKGRCGRV 403
Cdd:pfam00271 83 VDLVIN--------YDL----------PWNPASYIQRIGRAGRA 108
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
84-509 |
1.36e-07 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 55.67 E-value: 1.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 84 QEILEA-VRDHQVVIVAGETGSGKTT--QLPkICMELGRGVKGLIghtqprrLAA-RTVANRIAEELQT--EPGGcIGYK 157
Cdd:COG1204 28 AEALEAgLLEGKNLVVSAPTASGKTLiaELA-ILKALLNGGKALY-------IVPlRALASEKYREFKRdfEELG-IKVG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 158 VRFSDHVSDNTMVK-----LMT----DGILLAEIqqdRLLMQYDTIIIDEAH-----ERSLNIDFLLGYLREllpRRPDL 223
Cdd:COG1204 99 VSTGDYDSDDEWLGrydilVATpeklDSLLRNGP---SWLRDVDLVVVDEAHliddeSRGPTLEVLLARLRR---LNPEA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 224 KIIITSATID-PERFSRHFnNAPIIEVSGRtyPVE----VRYRPIVEDADDTERDQLQAIFDAVDELGREspGDILIFMS 298
Cdd:COG1204 173 QIVALSATIGnAEEIAEWL-DAELVKSDWR--PVPlnegVLYDGVLRFDDGSRRSKDPTLALALDLLEEG--GQVLVFVS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 299 GEREIRDTADAL-NKLNLRHT------------------EVLPLYARLSNSEQNRVFQAHSG-----RRIV--------- 345
Cdd:COG1204 248 SRRDAESLAKKLaDELKRRLTpeereeleelaeellevsEETHTNEKLADCLEKGVAFHHAGlpselRRLVedafregli 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 346 ---LATnvaeTSLT----VPgIKYVIdpgtarISRYSfRTKVQRLPIEPVSQASanqrkGRCGRVS-----EGICIRLYS 413
Cdd:COG1204 328 kvlVAT----PTLAagvnLP-ARRVI------IRDTK-RGGMVPIPVLEFKQMA-----GRAGRPGydpygEAILVAKSS 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 414 EDD-------FLSRPE-----FTDPEILRTNLASVILQMTALGLGDIAAF--------PFVEAPDKRNIQDGVRLLEELG 473
Cdd:COG1204 391 DEAdelferyILGEPEpirskLANESALRTHLLALIASGFANSREELLDFlentfyayQYDKGDLEEVVDDALEFLLENG 470
|
490 500 510
....*....|....*....|....*....|....*.
gi 1850347661 474 AITTDEQqtAYKLTPMGRQLSQLPVDPRLARMVLEA 509
Cdd:COG1204 471 FIEEDGD--RLRATKLGKLVSRLYIDPLTAAELVDG 504
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
84-235 |
2.48e-07 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 51.86 E-value: 2.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 84 QEILEAVRDHQVVIVAGETGSGKTT--QLP--KICMELGRGVKGLIghTQPRR-LAartvaNRIAEELQtEPGGCIGYKV 158
Cdd:pfam00270 5 AEAIPAILEGRDVLVQAPTGSGKTLafLLPalEALDKLDNGPQALV--LAPTReLA-----EQIYEELK-KLGKGLGLKV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 159 R--FSDHVSDNTMVKL-------MTDGILLAEIQQDRLLMQYDTIIIDEAHeRSLNIDF--LLGYLRELLPrrPDLKIII 227
Cdd:pfam00270 77 AslLGGDSRKEQLEKLkgpdilvGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFgpDLEEILRRLP--KKRQILL 153
|
....*...
gi 1850347661 228 TSATIDPE 235
Cdd:pfam00270 154 LSATLPRN 161
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
96-231 |
8.30e-06 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 47.01 E-value: 8.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 96 VIVAGETGSGKTT--QLPKICMELGRGVKGLIghTQPRrlaaRTVANRIAEELQTE--PGGCIGYKVRFSDhVSDNTMVK 171
Cdd:cd00046 4 VLITAPTGSGKTLaaLLAALLLLLKKGKKVLV--LVPT----KALALQTAERLRELfgPGIRVAVLVGGSS-AEEREKNK 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 172 LMTDGILLAEIQQDRLLMQ---------YDTIIIDEAHERSLNIDF-LLGYLRELLPRRPDLKIIITSAT 231
Cdd:cd00046 77 LGDADIIIATPDMLLNLLLredrlflkdLKLIIVDEAHALLIDSRGaLILDLAVRKAGLKNAQVILLSAT 146
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
87-512 |
1.53e-05 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 49.50 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 87 LEAVRDHQVVIVAGETGSGKT-TQLPKICMELGRGVKGLigHTQPrrlaARTVANRIAEELQTEPGgcIGYKVRFS--DH 163
Cdd:PRK01172 31 IEQLRKGENVIVSVPTAAGKTlIAYSAIYETFLAGLKSI--YIVP----LRSLAMEKYEELSRLRS--LGMRVKISigDY 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 164 VSDNTMVKlMTDGILLAEIQQDRLlMQYD--------TIIIDEAH-----ERSLNIDFLLGYLRELlprRPDLKIIITSA 230
Cdd:PRK01172 103 DDPPDFIK-RYDVVILTSEKADSL-IHHDpyiindvgLIVADEIHiigdeDRGPTLETVLSSARYV---NPDARILALSA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 231 TIDPERFSRHFNNAPIIEVSGRTYPVEV----RYRPIVEDADDTERDQLQAIFDAVDElgresPGDILIFMSGEREIRDT 306
Cdd:PRK01172 178 TVSNANELAQWLNASLIKSNFRPVPLKLgilyRKRLILDGYERSQVDINSLIKETVND-----GGQVLVFVSSRKNAEDY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 307 ADALNKL-----NLRHT------------EVLPL-----YARLSNSEQNRVFQAHSGRRI--VLATNVAETSLTVPGiKY 362
Cdd:PRK01172 253 AEMLIQHfpefnDFKVSsennnvyddslnEMLPHgvafhHAGLSNEQRRFIEEMFRNRYIkvIVATPTLAAGVNLPA-RL 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 363 VIdpgTARISRYSfrtkvqRLPIEPVSQASANQRKGRCGRV---SEGICIrLYSED--------DFLS-RPEFTD----- 425
Cdd:PRK01172 332 VI---VRDITRYG------NGGIRYLSNMEIKQMIGRAGRPgydQYGIGY-IYAASpasydaakKYLSgEPEPVIsymgs 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 426 PEILRTNLASVILQMTALGLGDIAAF---------PFVEAPDKRnIQDGVRLLEELGAIttdEQQTAYKLTPMGRQLSQL 496
Cdd:PRK01172 402 QRKVRFNTLAAISMGLASSMEDLILFynetlmaiqNGVDEIDYY-IESSLKFLKENGFI---KGDVTLRATRLGKLTSDL 477
|
490
....*....|....*.
gi 1850347661 497 PVDPRLARMVLEAQKH 512
Cdd:PRK01172 478 YIDPESALILKSAFDH 493
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
84-364 |
1.91e-04 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 45.79 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 84 QEILEAV-----RDHQVVIVAGETGSGKTTQLPKICMELGRGVKGLIghtqprrLAARTV-ANRIAEELQTEPGGCIGYk 157
Cdd:COG1061 86 QEALEALlaaleRGGGRGLVVAPTGTGKTVLALALAAELLRGKRVLV-------LVPRRElLEQWAEELRRFLGDPLAG- 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 158 vrfSDHVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIdfllgyLRELLPRRPDLKIIITSATidPER- 236
Cdd:COG1061 158 ---GGKKDSDAPITVATYQSLARRAHLDELGDRFGLVIIDEAHHAGAPS------YRRILEAFPAAYRLGLTAT--PFRs 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 237 ------FSRHFN---NAPIIEVSGRTYPVEVRYRPIVED----------ADDTERDQL----QAIFDAVDELGRESPGD- 292
Cdd:COG1061 227 dgreilLFLFDGivyEYSLKEAIEDGYLAPPEYYGIRVDltderaeydaLSERLREALaadaERKDKILRELLREHPDDr 306
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1850347661 293 -ILIFMSGEREIRDTADALNKLNLRhteVLPLYARLSNSEQNRVFQA-HSGR-RIVLATNVAETSLTVPGIKYVI 364
Cdd:COG1061 307 kTLVFCSSVDHAEALAELLNEAGIR---AAVVTGDTPKKEREEILEAfRDGElRILVTVDVLNEGVDVPRLDVAI 378
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
94-250 |
1.14e-03 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 41.00 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 94 QVVIVAGETGSGKTTQ-LPKICMELGR-GVKGLIghtqprrLA-ARTVANRIAEELQTEPggcIGYK--VRFSDHvSDNT 168
Cdd:cd17931 2 QLTVLDLHPGAGKTTRvLPQIIREAIKkRLRTLV-------LApTRVVAAEMYEALRGLP---IRYRtgAVKEEH-GGNE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 169 MVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLRELLpRRPDLKIIITSATIDPERFSRHFNNAPIIE 248
Cdd:cd17931 71 IVDYMCHGTFTCRLLSPKRVPNYNLIIMDEAHFTDPASIAARGYIHTRV-EMGEAAVIFMTATPPGTVTPFPQSNHPIED 149
|
..
gi 1850347661 249 VS 250
Cdd:cd17931 150 FE 151
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
187-377 |
1.45e-03 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 42.42 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 187 LLMQYDTIIIDEAHERSLNIDFLLGYLRELLpRRPDLKIIITSATIdPERFSRHF-NNAPIIEVSGRTY-PVEVRYRPIV 264
Cdd:cd09639 120 ASIANSLLIFDEVHFYDEYTLALILAVLEVL-KDNDVPILLMSATL-PKFLKEYAeKIGYVEENEPLDLkPNERAPFIKI 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 265 EDADDTERDQLQAIFDAVDElgresPGDILIFMSGEREIRDTADALNKLNlRHTEVLPLYARLSNS------EQNRVFQA 338
Cdd:cd09639 198 ESDKVGEISSLERLLEFIKK-----GGSVAIIVNTVDRAQEFYQQLKEKG-PEEEIMLIHSRFTEKdrakkeAELLLEFK 271
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1850347661 339 HSGRRIVLATNVAETSLTVPGIKYVIDPGTA--------RISRYSFR 377
Cdd:cd09639 272 KSEKFVIVATQVIEASLDISVDVMITELAPIdsliqrlgRLHRYGEK 318
|
|
| cas3_core |
TIGR01587 |
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ... |
95-407 |
2.90e-03 |
|
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Pssm-ID: 273707 [Multi-domain] Cd Length: 359 Bit Score: 41.67 E-value: 2.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 95 VVIVAgETGSGKTT-QLPKICMELGRGVKGLIGHTQPRRLAARTVANRIAEELQTEPGGCIGYKV--RFSDHVSDNTMVK 171
Cdd:TIGR01587 2 LVIEA-PTGYGKTEaALLWALHSIKSQKADRVIIALPTRATINAMYRRAKELFGSELVGLHHSSSfsRIKEMGDSEEFEH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 172 LMT-----------DGILLAEIQQ-----DRLLMQYDT---------IIIDEAHERSLNIDFLLGYLRELLpRRPDLKII 226
Cdd:TIGR01587 81 LFPlyihsndklflDPITVCTIDQvlksvFGEFGHYEFtlasianslLIFDEVHFYDEYTLALILAVLEVL-KDNDVPIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 227 ITSATIdPERFSRHF-NNAPIIEVSGRTYPVEVRYR----PIVEDADDTERDQLQAIFDAVDElgresPGDILIFMSGER 301
Cdd:TIGR01587 160 LMSATL-PKFLKEYAeKIGYVEFNEPLDLKEERRFEnhrfILIESDKVGEISSLERLLEFIKK-----GGSIAIIVNTVD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 302 EIRDTADALNKLNlrHTEVLPLY---------ARLSNSEQNRVFQAHSGRRIVlATNVAETSLTvpgikyvidpgtarIS 372
Cdd:TIGR01587 234 RAQEFYQQLKEKA--PEEEIILYhsrftekdrAKKEAELLREMKKSNEKFVIV-ATQVIEASLD--------------IS 296
|
330 340 350
....*....|....*....|....*....|....*
gi 1850347661 373 RYSFRTkvqrlpiEPVSQASANQRKGRCGRVSEGI 407
Cdd:TIGR01587 297 ADVMIT-------ELAPIDSLIQRLGRLHRYGRKI 324
|
|
| FlhF |
TIGR03499 |
flagellar biosynthetic protein FlhF; [Cellular processes, Chemotaxis and motility] |
46-113 |
6.14e-03 |
|
flagellar biosynthetic protein FlhF; [Cellular processes, Chemotaxis and motility]
Pssm-ID: 274609 [Multi-domain] Cd Length: 282 Bit Score: 40.01 E-value: 6.14e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1850347661 46 ILQEMAQEIEQAAGRVLLREAARPAIAypENLPVSQKKQEILEavrDHQVVIVAGETGSGKTTQLPKI 113
Cdd:TIGR03499 152 LARELLEKLPEDADAEDAWRWLREALE--GMLPVKPEEDPILE---QGGVIALVGPTGVGKTTTLAKL 214
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
93-229 |
6.84e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 38.51 E-value: 6.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1850347661 93 HQVVIVAGETGSGKTTQLPKICMELGRGVKGLIghtqprRLAARTVANRIAEELQTEPGGcigykvrfsdhvsdntMVKL 172
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALARELGPPGGGVI------YIDGEDILEEVLDQLLLIIVG----------------GKKA 59
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1850347661 173 MTDGILLAEIQQDRLL-MQYDTIIIDEAH------ERSLNIDFLLGYLRELLPRRPDLKIIITS 229
Cdd:smart00382 60 SGSGELRLRLALALARkLKPDVLILDEITslldaeQEALLLLLEELRLLLLLKSEKNLTVILTT 123
|
|
| |
