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Conserved domains on  [gi|1933688828|gb|QPE80149|]
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GNAT family N-acetyltransferase [Escherichia coli]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10003213)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 10-167 3.68e-28

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


:

Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 101.61  E-value: 3.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  10 VMRRLTQQDNPAIARVIRQVsaeygltadkgytvadpnldelyqVYSQPGHAYWVVEFDGEVVGGGGIAPLAGsesDICE 89
Cdd:COG1246     2 TIRPATPDDVPAILELIRPY------------------------ALEEEIGEFWVAEEDGEIVGCAALHPLDE---DLAE 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  90 LQKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLETTAflkEAIALYEHLGFEHIDYALGCTGHVD--CEVRMLREL 167
Cdd:COG1246    55 LRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTS---AAIHFYEKLGFEEIDKEDLPYAKVWqrDSVVMEKDL 131
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 10-167 3.68e-28

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 101.61  E-value: 3.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  10 VMRRLTQQDNPAIARVIRQVsaeygltadkgytvadpnldelyqVYSQPGHAYWVVEFDGEVVGGGGIAPLAGsesDICE 89
Cdd:COG1246     2 TIRPATPDDVPAILELIRPY------------------------ALEEEIGEFWVAEEDGEIVGCAALHPLDE---DLAE 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  90 LQKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLETTAflkEAIALYEHLGFEHIDYALGCTGHVD--CEVRMLREL 167
Cdd:COG1246    55 LRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTS---AAIHFYEKLGFEEIDKEDLPYAKVWqrDSVVMEKDL 131
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 35-144 2.02e-19

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 78.71  E-value: 2.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  35 LTADKGYTVADPNLDELYQVYSQPGHAYWVVEFDGEVVGGGGIAPLaGSESDICELQKMYFLPAIRGKGLAKKLALMAME 114
Cdd:pfam00583   8 LSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSII-DDEPPVGEIEGLAVAPEYRGKGIGTALLQALLE 86

                          90       100       110
                  ....*....|....*....|....*....|
gi 1933688828 115 QAREMGFKRCYLETTAFLKEAIALYEHLGF 144
Cdd:pfam00583  87 WARERGCERIFLEVAADNLAAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 62-127 4.91e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 52.66  E-value: 4.91e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1933688828  62 YWVVEFDGEVVGGGGIAPlAGSESDICELQKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLE 127
Cdd:cd04301     1 FLVAEDDGEIVGFASLSP-DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
PRK07757 PRK07757
N-acetyltransferase;
11-148 1.34e-06

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 45.57  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  11 MRRLTQQDNPAIARVIrqvsAEYgltADKGYTVADPnLDELYQvysqpgH--AYWVVEFDGEVVGGGGIAPLAgseSDIC 88
Cdd:PRK07757    4 IRKARLSDVKAIHALI----NVY---AKKGLMLPRS-LDELYE------NirDFYVAEEEGEIVGCCALHILW---EDLA 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1933688828  89 ELQKMYFLPAIRGKGLAKKLALMAMEQAREMGfkrcylettafLKEAIAL------YEHLGFEHID 148
Cdd:PRK07757   67 EIRSLAVSEDYRGQGIGRMLVEACLEEARELG-----------VKRVFALtyqpefFEKLGFREVD 121
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 47-148 7.53e-05

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 40.39  E-value: 7.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  47 NLDELYQVYSQPGHAYWVVEFDGEVVG--GGGIAPLAGSESDICelqkmyFLPAIRGKGLAKKLALMAMEQAREMGFKRC 124
Cdd:TIGR01575  18 TEAQFAEELANYHLCYLLARIGGKVVGyaGVQIVLDEAHILNIA------VKPEYQGQGIGRALLRELIDEAKGRGVNEI 91

                          90       100
                  ....*....|....*....|....
gi 1933688828 125 YLETTAFLKEAIALYEHLGFEHID 148
Cdd:TIGR01575  92 FLEVRVSNIAAQALYKKLGFNEIA 115
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 10-167 3.68e-28

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 101.61  E-value: 3.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  10 VMRRLTQQDNPAIARVIRQVsaeygltadkgytvadpnldelyqVYSQPGHAYWVVEFDGEVVGGGGIAPLAGsesDICE 89
Cdd:COG1246     2 TIRPATPDDVPAILELIRPY------------------------ALEEEIGEFWVAEEDGEIVGCAALHPLDE---DLAE 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  90 LQKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLETTAflkEAIALYEHLGFEHIDYALGCTGHVD--CEVRMLREL 167
Cdd:COG1246    55 LRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTS---AAIHFYEKLGFEEIDKEDLPYAKVWqrDSVVMEKDL 131
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
8-148 1.53e-20

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 82.73  E-value: 1.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828   8 SPVMRRLTQQDNPAIARVIRQVSAEYGLTADKGyTVADPNLDELYQVYSQPGHAYWVVEFDGEVVGGGGIAPLAGSE--S 85
Cdd:COG1247     1 EMTIRPATPEDAPAIAAIYNEAIAEGTATFETE-PPSEEEREAWFAAILAPGRPVLVAEEDGEVVGFASLGPFRPRPayR 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1933688828  86 DICELQkMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLETTAFLKEAIALYEHLGFEHID 148
Cdd:COG1247    80 GTAEES-IYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVG 141
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 35-144 2.02e-19

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 78.71  E-value: 2.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  35 LTADKGYTVADPNLDELYQVYSQPGHAYWVVEFDGEVVGGGGIAPLaGSESDICELQKMYFLPAIRGKGLAKKLALMAME 114
Cdd:pfam00583   8 LSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSII-DDEPPVGEIEGLAVAPEYRGKGIGTALLQALLE 86

                          90       100       110
                  ....*....|....*....|....*....|
gi 1933688828 115 QAREMGFKRCYLETTAFLKEAIALYEHLGF 144
Cdd:pfam00583  87 WARERGCERIFLEVAADNLAAIALYEKLGF 116
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 54-148 3.66e-18

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 75.86  E-value: 3.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  54 VYSQPGHAYWVVEFDGEVVGGGGIAPLAGsesDICELQKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLETTAFLK 133
Cdd:COG0454    28 EGSLAGAEFIAVDDKGEPIGFAGLRRLDD---KVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALELDTLDGNP 104

                          90
                  ....*....|....*
gi 1933688828 134 EAIALYEHLGFEHID 148
Cdd:COG0454   105 AAIRFYERLGFKEIE 119
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
12-167 1.68e-15

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 68.96  E-value: 1.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  12 RRLTQQDNPAIARVIRQVSAEyGLTADKGYTVADPNLDELYqvysqpghayWVVEFDGEVVGGGGIAPL-AGSESDICEL 90
Cdd:COG3153     2 RPATPEDAEAIAALLRAAFGP-GREAELVDRLREDPAAGLS----------LVAEDDGEIVGHVALSPVdIDGEGPALLL 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1933688828  91 QKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLETTAflkEAIALYEHLGFEHIDYALGCTGhvDCEVRMLREL 167
Cdd:COG3153    71 GPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDP---SLLPFYERFGFRPAGELGLTLG--PDEVFLAKEL 142
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 84-167 1.82e-14

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 65.06  E-value: 1.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  84 ESDICELQKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLETTAFLKEAIALYEHLGFEHIDYALGCtgHVDCEVRM 163
Cdd:COG0456    10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNY--YGDDALVM 87


                  ....
gi 1933688828 164 LREL 167
Cdd:COG0456    88 EKEL 91
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 58-145 1.20e-13

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 62.86  E-value: 1.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  58 PGHAYWVVEFDGEVVGGGGIAPLAGsESDICELqKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLETTaflKEAIA 137
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDD-EGALAEL-RLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETT---NRAAA 75


                  ....*...
gi 1933688828 138 LYEHLGFE 145
Cdd:pfam13508  76 FYEKLGFE 83
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
70-147 2.14e-13

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 62.23  E-value: 2.14e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1933688828  70 EVVGGGGIAPLAGsesDICELQKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLETTAFLKEAIALYEHLGFEHI 147
Cdd:COG3393     1 ELVAMAGVRAESP---GVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPV 75
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 10-147 2.10e-12

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 61.55  E-value: 2.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  10 VMRRLTQQDNPAIARVIRQVS-AEYGLTADKGYTVADPNLDELYQVYSQPGHAYWVVEF--DGEVVGGGGIAPLAGsESD 86
Cdd:COG1670     9 RLRPLRPEDAEALAELLNDPEvARYLPGPPYSLEEARAWLERLLADWADGGALPFAIEDkeDGELIGVVGLYDIDR-ANR 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1933688828  87 ICELQkMYFLPAIRGKGLAKKLALMAMEQA-REMGFKRCYLETTAFLKEAIALYEHLGFEHI 147
Cdd:COG1670    88 SAEIG-YWLAPAYWGKGYATEALRALLDYAfEELGLHRVEAEVDPDNTASIRVLEKLGFRLE 148
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 62-127 4.91e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 52.66  E-value: 4.91e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1933688828  62 YWVVEFDGEVVGGGGIAPlAGSESDICELQKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLE 127
Cdd:cd04301     1 FLVAEDDGEIVGFASLSP-DGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
64-145 8.45e-08

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 48.64  E-value: 8.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  64 VVEFDGEVVGGGGIAPLagsESDICELQKMYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLETTAflkEAIALYEHLG 143
Cdd:COG2153    38 LAYDDGELVATARLLPP---GDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQA---HAVGFYEKLG 111


                  ..
gi 1933688828 144 FE 145
Cdd:COG2153   112 FV 113
PRK07757 PRK07757
N-acetyltransferase;
11-148 1.34e-06

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 45.57  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  11 MRRLTQQDNPAIARVIrqvsAEYgltADKGYTVADPnLDELYQvysqpgH--AYWVVEFDGEVVGGGGIAPLAgseSDIC 88
Cdd:PRK07757    4 IRKARLSDVKAIHALI----NVY---AKKGLMLPRS-LDELYE------NirDFYVAEEEGEIVGCCALHILW---EDLA 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1933688828  89 ELQKMYFLPAIRGKGLAKKLALMAMEQAREMGfkrcylettafLKEAIAL------YEHLGFEHID 148
Cdd:PRK07757   67 EIRSLAVSEDYRGQGIGRMLVEACLEEARELG-----------VKRVFALtyqpefFEKLGFREVD 121
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 49-148 1.41e-05

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 42.26  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  49 DELYQVYSQPGHAYWVVEFDGEVVGGGGIaplaGSESDICELqkmYFLPAIRGKGLAKKLALMAMEQAREMGFKRCYLET 128
Cdd:pfam13673  20 EALRERIDQGEYFFFVAFEGGQIVGVIAL----RDRGHISLL---FVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTV 92

                          90       100
                  ....*....|....*....|
gi 1933688828 129 TAfLKEAIALYEHLGFEHID 148
Cdd:pfam13673  93 NA-SPYAVPFYEKLGFRATG 111
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 47-148 7.53e-05

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 40.39  E-value: 7.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  47 NLDELYQVYSQPGHAYWVVEFDGEVVG--GGGIAPLAGSESDICelqkmyFLPAIRGKGLAKKLALMAMEQAREMGFKRC 124
Cdd:TIGR01575  18 TEAQFAEELANYHLCYLLARIGGKVVGyaGVQIVLDEAHILNIA------VKPEYQGQGIGRALLRELIDEAKGRGVNEI 91

                          90       100
                  ....*....|....*....|....
gi 1933688828 125 YLETTAFLKEAIALYEHLGFEHID 148
Cdd:TIGR01575  92 FLEVRVSNIAAQALYKKLGFNEIA 115
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 97-122 1.32e-04

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 38.66  E-value: 1.32e-04
                          10        20
                  ....*....|....*....|....*.
gi 1933688828  97 PAIRGKGLAKKLALMAMEQAREMGFK 122
Cdd:pfam14542  33 PALRGQGIASKLVKAALDDAREEGLK 58
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 97-148 3.59e-04

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 38.76  E-value: 3.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1933688828  97 PAIRGKGLAKKLALMAMEQAREMGFKRCYLETTAFLKEAIALYEHLGFEHID 148
Cdd:PRK09491   73 PDYQRQGLGRALLEHLIDELEKRGVATLWLEVRASNAAAIALYESLGFNEVT 124
YidJ COG2388
Predicted acetyltransferase, GNAT superfamily [General function prediction only];
97-122 2.19e-03

Predicted acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 441953 [Multi-domain]  Cd Length: 88  Bit Score: 35.52  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|....*.
gi 1933688828  97 PAIRGKGLAKKLALMAMEQAREMGFK 122
Cdd:COG2388    42 PALRGQGIASALVEAALDDARERGLK 67
Acetyltransf_3 pfam13302
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 10-145 3.72e-03

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 379112 [Multi-domain]  Cd Length: 139  Bit Score: 35.78  E-value: 3.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688828  10 VMRRLTQQDNPAIARV-----IRQVSAEYGLTADKGYTVADPNLDELYQvysQPGHAYWVVEFDGEVVGGGGIAPLAGsE 84
Cdd:pfam13302   3 LLRPLTEEDAEALFELlsdpeVMRYGVPWPLTLEEAREWLARIWAADEA---ERGYGWAIELKDTGFIGSIGLYDIDG-E 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1933688828  85 SDICELqKMYFLPAIRGKGLAKKLALMAMEQA-REMGFKRCYLETTAFLKEAIALYEHLGFE 145
Cdd:pfam13302  79 PERAEL-GYWLGPDYWGKGYATEAVRALLEYAfEELGLPRLVARIDPENTASRRVLEKLGFK 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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