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Conserved domains on  [gi|1933688833|gb|QPE80154|]
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TetR/AcrR family transcriptional regulator [Escherichia coli]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
12-148 2.29e-13

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 64.53  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688833  12 RPRRFAPEQAVSAAKVLFHQKGFDAVSVAEVTDYLGINPPSLYAAFGSKAGLFSRVLNEYVGTEAIPLADILRDDRPVgE 91
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPR-E 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1933688833  92 CLVEVLKEAARRYSQNGGCAGCMVLEGIhsHDPQARDIAVQYYHAAETTIYDYIARR 148
Cdd:COG1309    81 RLRALLRAYLEFLAENPALARLLLAEAA--ELPELRAALRALLRRLRALLAELLRAG 135
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
12-148 2.29e-13

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 64.53  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688833  12 RPRRFAPEQAVSAAKVLFHQKGFDAVSVAEVTDYLGINPPSLYAAFGSKAGLFSRVLNEYVGTEAIPLADILRDDRPVgE 91
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPR-E 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1933688833  92 CLVEVLKEAARRYSQNGGCAGCMVLEGIhsHDPQARDIAVQYYHAAETTIYDYIARR 148
Cdd:COG1309    81 RLRALLRAYLEFLAENPALARLLLAEAA--ELPELRAALRALLRRLRALLAELLRAG 135
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
22-67 1.23e-09

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 51.64  E-value: 1.23e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1933688833  22 VSAAKVLFHQKGFDAVSVAEVTDYLGINPPSLYAAFGSKAGLFSRV 67
Cdd:pfam00440   2 LDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
12-148 2.29e-13

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 64.53  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933688833  12 RPRRFAPEQAVSAAKVLFHQKGFDAVSVAEVTDYLGINPPSLYAAFGSKAGLFSRVLNEYVGTEAIPLADILRDDRPVgE 91
Cdd:COG1309     2 RRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPR-E 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1933688833  92 CLVEVLKEAARRYSQNGGCAGCMVLEGIhsHDPQARDIAVQYYHAAETTIYDYIARR 148
Cdd:COG1309    81 RLRALLRAYLEFLAENPALARLLLAEAA--ELPELRAALRALLRRLRALLAELLRAG 135
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
22-67 1.23e-09

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 51.64  E-value: 1.23e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1933688833  22 VSAAKVLFHQKGFDAVSVAEVTDYLGINPPSLYAAFGSKAGLFSRV 67
Cdd:pfam00440   2 LDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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