NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1933716674|gb|QPE93847|]
View 

HNH endonuclease [Escherichia coli O152:H23]

Protein Classification

HNH endonuclease( domain architecture ID 11465816)

HNH endonuclease similar to Haemophilus parahaemolyticus type II restriction enzyme HphI, which recognizes the double-stranded sequences, GGTGA and TCACC, and performs endonucleolytic cleavage of DNA to give specific double-stranded fragments

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG3440 COG3440
Predicted restriction endonuclease [Defense mechanisms];
135-289 3.90e-56

Predicted restriction endonuclease [Defense mechanisms];


:

Pssm-ID: 442665  Cd Length: 150  Bit Score: 177.88  E-value: 3.90e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933716674 135 AQQILEAHFTESIQEEIADElGFDLQQIRKQRDPLFRKNVLRAYNYQCAICGFnmrhdDTTVALEAAHIK-WKQHGGPCE 213
Cdd:COG3440     1 AEQLLDALFLEEEPDELERT-ERERLVKRRVRQGAFRKAVLEAYDGRCAVTGL-----DIPPLLEAAHIKpWSDHGGRDD 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1933716674 214 IPNGLALCAIHHKAFDKGSIGLDENMRVLVSDAVNGGGIVEKLFWDFDGKTIALPQVRKNYPFEVFVEWHRKEVFR 289
Cdd:COG3440    75 VSNGLLLCPNHHALFDRGLITIDDDYRILVSPRLKEESDLIRELKELHGRKLRLPEHERFRPDPEYLAWHRENVFK 150
 
Name Accession Description Interval E-value
COG3440 COG3440
Predicted restriction endonuclease [Defense mechanisms];
135-289 3.90e-56

Predicted restriction endonuclease [Defense mechanisms];


Pssm-ID: 442665  Cd Length: 150  Bit Score: 177.88  E-value: 3.90e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933716674 135 AQQILEAHFTESIQEEIADElGFDLQQIRKQRDPLFRKNVLRAYNYQCAICGFnmrhdDTTVALEAAHIK-WKQHGGPCE 213
Cdd:COG3440     1 AEQLLDALFLEEEPDELERT-ERERLVKRRVRQGAFRKAVLEAYDGRCAVTGL-----DIPPLLEAAHIKpWSDHGGRDD 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1933716674 214 IPNGLALCAIHHKAFDKGSIGLDENMRVLVSDAVNGGGIVEKLFWDFDGKTIALPQVRKNYPFEVFVEWHRKEVFR 289
Cdd:COG3440    75 VSNGLLLCPNHHALFDRGLITIDDDYRILVSPRLKEESDLIRELKELHGRKLRLPEHERFRPDPEYLAWHRENVFK 150
HNH_2 pfam13391
HNH endonuclease;
182-236 3.44e-08

HNH endonuclease;


Pssm-ID: 433168  Cd Length: 66  Bit Score: 49.32  E-value: 3.44e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1933716674 182 CAICGFnmrhdDTTVALEAAHIKWKQH-------------GGPCEIP---NGLALCAIHHKAFDKGSIGLD 236
Cdd:pfam13391   1 CVITGI-----DAPGLLEAAHIFPWSLslgdrrfsairlgEGPSGIDsprNGLLLRPDLHRLFDRGLFAID 66
 
Name Accession Description Interval E-value
COG3440 COG3440
Predicted restriction endonuclease [Defense mechanisms];
135-289 3.90e-56

Predicted restriction endonuclease [Defense mechanisms];


Pssm-ID: 442665  Cd Length: 150  Bit Score: 177.88  E-value: 3.90e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933716674 135 AQQILEAHFTESIQEEIADElGFDLQQIRKQRDPLFRKNVLRAYNYQCAICGFnmrhdDTTVALEAAHIK-WKQHGGPCE 213
Cdd:COG3440     1 AEQLLDALFLEEEPDELERT-ERERLVKRRVRQGAFRKAVLEAYDGRCAVTGL-----DIPPLLEAAHIKpWSDHGGRDD 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1933716674 214 IPNGLALCAIHHKAFDKGSIGLDENMRVLVSDAVNGGGIVEKLFWDFDGKTIALPQVRKNYPFEVFVEWHRKEVFR 289
Cdd:COG3440    75 VSNGLLLCPNHHALFDRGLITIDDDYRILVSPRLKEESDLIRELKELHGRKLRLPEHERFRPDPEYLAWHRENVFK 150
HNH_2 pfam13391
HNH endonuclease;
182-236 3.44e-08

HNH endonuclease;


Pssm-ID: 433168  Cd Length: 66  Bit Score: 49.32  E-value: 3.44e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1933716674 182 CAICGFnmrhdDTTVALEAAHIKWKQH-------------GGPCEIP---NGLALCAIHHKAFDKGSIGLD 236
Cdd:pfam13391   1 CVITGI-----DAPGLLEAAHIFPWSLslgdrrfsairlgEGPSGIDsprNGLLLRPDLHRLFDRGLFAID 66
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
163-227 1.97e-05

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 41.51  E-value: 1.97e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1933716674 163 RKQRDPLFRKNVLRAYNYQCAICGFNMRHDDTTValeaAHIKWKQHGGPCEIPNGLALCAIHHKA 227
Cdd:COG1403     3 PGREWPALRRAVLKRDNGRCQYCGRPFSGDALEV----DHIIPRSRGGTDTWENLVLLCRRCNRR 63
COG3183 COG3183
Predicted restriction endonuclease, HNH family [Defense mechanisms];
166-239 3.71e-03

Predicted restriction endonuclease, HNH family [Defense mechanisms];


Pssm-ID: 442416 [Multi-domain]  Cd Length: 112  Bit Score: 36.51  E-value: 3.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1933716674 166 RDPLFRKNVLRAYNYQCAICGFNMRHDDTTVA---LEAAHIKW--KQH-GGPCEIPNGLALCAIHHKAFDKGSIGLDENM 239
Cdd:COG3183    23 RNPKLRKKAKEHAGGKCEVCGFDFEFVYGELGegyIEVHHLIPlsEIGeGGVDPIEDLVPLCPNCHRMLHRGRPPLSIEE 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH