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Conserved domains on  [gi|1943226393|gb|QPS49273|]
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3-phosphoshikimate 1-carboxyvinyltransferase [Bacillus tropicus]

Protein Classification

3-phosphoshikimate 1-carboxyvinyltransferase( domain architecture ID 11414790)

3-phosphoshikimate 1- carboxyvinyltransferase catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; 3-phosphoshikimate 1-carboxyvinyltransferase catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate

EC:  2.5.1.19
Gene Ontology:  GO:0009073|GO:0008652|GO:0003866|GO:0009423
PubMed:  8973316|17348837
SCOP:  4001425

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AroA COG0128
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ...
 1-427 0e+00

5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


:

Pssm-ID: 439898  Cd Length: 421  Bit Score: 575.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393   1 MKERTIQPvNNGLNGNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDI-VQNGDEVTVVGKGl 79
Cdd:COG0128     1 MSSLTIAP-PSPLKGTVRVPGSKSISHRALLLAALAEGESTIRNLLESDDTLATLEALRALGAEIeELDGGTLRVTGVG- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  80 EGLQEPKAVLDVGNSGTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGtFTPLTIRGGDLKA 159
Cdd:COG0128    79 GGLKEPDAVLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQLGARIESRGGG-YLPLTIRGGPLKG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 160 IEYTSP-VASAQVKSAILLAGLRAEG-----VTAVTEPHISRDHTERMLEAFGVKVTREG-KTVKLAGGQKLTATDVQVP 232
Cdd:COG0128   158 GEYEIPgSASSQFKSALLLAGPLAEGgleitVTGELESKPYRDHTERMLRAFGVEVEVEGyRRFTVPGGQRYRPGDYTVP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 233 GDVSSAAFFLVAGAIIpNSKLVLQNVGMNPT--RTGIIDVLEKMGATFTVEpiNEGasepaanITIETSSLKGIEIGGDI 310
Cdd:COG0128   238 GDISSAAFFLAAAAIT-GSEVTVEGVGLNSTqgDTGILDILKEMGADIEIE--NDG-------ITVRGSPLKGIDIDLSD 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 311 IPrliDEIPVIALAATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKSALKGNTVNSYGDHRI 390
Cdd:COG0128   308 IP---DEAPTLAVLAAFAEGTTRIRGAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPKLKGAEVDSYGDHRI 384

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1943226393 391 GMMLAIAGCIAEGKTTIEDAEAVGVSYPTFFEELQKL 427
Cdd:COG0128   385 AMAFAVAGLRAEGPVTIDDAECVAKSFPDFFELLESL 421
 
Name Accession Description Interval E-value
AroA COG0128
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ...
 1-427 0e+00

5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439898  Cd Length: 421  Bit Score: 575.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393   1 MKERTIQPvNNGLNGNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDI-VQNGDEVTVVGKGl 79
Cdd:COG0128     1 MSSLTIAP-PSPLKGTVRVPGSKSISHRALLLAALAEGESTIRNLLESDDTLATLEALRALGAEIeELDGGTLRVTGVG- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  80 EGLQEPKAVLDVGNSGTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGtFTPLTIRGGDLKA 159
Cdd:COG0128    79 GGLKEPDAVLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQLGARIESRGGG-YLPLTIRGGPLKG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 160 IEYTSP-VASAQVKSAILLAGLRAEG-----VTAVTEPHISRDHTERMLEAFGVKVTREG-KTVKLAGGQKLTATDVQVP 232
Cdd:COG0128   158 GEYEIPgSASSQFKSALLLAGPLAEGgleitVTGELESKPYRDHTERMLRAFGVEVEVEGyRRFTVPGGQRYRPGDYTVP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 233 GDVSSAAFFLVAGAIIpNSKLVLQNVGMNPT--RTGIIDVLEKMGATFTVEpiNEGasepaanITIETSSLKGIEIGGDI 310
Cdd:COG0128   238 GDISSAAFFLAAAAIT-GSEVTVEGVGLNSTqgDTGILDILKEMGADIEIE--NDG-------ITVRGSPLKGIDIDLSD 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 311 IPrliDEIPVIALAATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKSALKGNTVNSYGDHRI 390
Cdd:COG0128   308 IP---DEAPTLAVLAAFAEGTTRIRGAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPKLKGAEVDSYGDHRI 384

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1943226393 391 GMMLAIAGCIAEGKTTIEDAEAVGVSYPTFFEELQKL 427
Cdd:COG0128   385 AMAFAVAGLRAEGPVTIDDAECVAKSFPDFFELLESL 421
PRK02427 PRK02427
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
 1-429 0e+00

3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 235037 [Multi-domain]  Cd Length: 435  Bit Score: 567.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393   1 MKERTIQPVNnGLNGNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDIVQngDEVTVVGKGLE 80
Cdd:PRK02427    2 MMMLLIIPPS-PLSGTVRVPGSKSISHRALLLAALAEGETTITNLLRSEDTLATLNALRALGVEIED--DEVVVEGVGGG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  81 GLQEPKAVLDVGNSGTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGtFTPLTIRGG-DLKA 159
Cdd:PRK02427   79 GLKEPEDVLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQMGAKIEGRDEG-YLPLTIRGGkKGGP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 160 IEYTSPVASAQVKSAILLAGLRAEG--VTAVTEPHISRDHTE---RMLEAFGVKVTREG----KTVKLAGGQKLTATDVQ 230
Cdd:PRK02427  158 IEYDGPVSSQFVKSLLLLAPLFAEGdtETTVIEPLPSRPHTEitlRMLRAFGVEVENVEgwgyRRIVIKGGQRLRGQDIT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 231 VPGDVSSAAFFLVAGAIIPNSKLVLQNVGMNPTRTG--IIDVLEKMGATFTVEPINEGaSEPAANITIETSSLKGIEIGg 308
Cdd:PRK02427  238 VPGDPSSAAFFLAAAAITGGSEVTITNVGLNSTQGGkaIIDVLEKMGADIEIENEREG-GEPVGDIRVRSSELKGIDID- 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 309 diIPRLIDEIPVIALAATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKSalKGNTVNSYGDH 388
Cdd:PRK02427  316 --IPDIIDEAPTLAVLAAFAEGTTVIRNAEELRVKETDRIAAMATELRKLGAEVEETEDGLIITGGP--LAGVVDSYGDH 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1943226393 389 RIGMMLAIAGCIAEGKTTIEDAEAVGVSYPTFFEELQKLAK 429
Cdd:PRK02427  392 RIAMAFAIAGLAAEGPVTIDDPECVAKSFPDFFEDLASLGA 432
EPSP_synthase cd01556
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase ...
 13-427 2.17e-178

EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.


Pssm-ID: 238797  Cd Length: 409  Bit Score: 503.63  E-value: 2.17e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  13 LNGNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDIVQNGDEVTVVGKGLeGLQEPKAVLDVG 92
Cdd:cd01556     1 LSGEITVPGSKSISHRALLLAALAEGESRIENLLDSDDTLATLEALRALGAKIEEEGGTVEIVGGGG-LGLPPEAVLDCG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  93 NSGTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGTFTPLtIRGGDLKAIEYTSPVA-SAQV 171
Cdd:cd01556    80 NSGTTMRLLTGLLALQGGDSVLTGDESLRKRPMGRLVDALRQLGAEIEGREGGGYPPL-IGGGGLKGGEVEIPGAvSSQF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 172 KSAILLAGLRAEGVTAVT----EPHISRDHTERMLEAFGVKVTREG-KTVKLAGGQKLTATDVQVPGDVSSAAFFLVAGA 246
Cdd:cd01556   159 KSALLLAAPLAEGPTTIIigelESKPYIDHTERMLRAFGAEVEVDGyRTITVKGGQKYKGPEYTVEGDASSAAFFLAAAA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 247 IIPnSKLVLQNVGMNPTRTGIIDVLEKMGATFTVEPINEgasepaanITIE-TSSLKGIEIGGDIIPrliDEIPVIALAA 325
Cdd:cd01556   239 ITG-SEIVIKNVGLNSGDTGIIDVLKEMGADIEIGNEDT--------VVVEsGGKLKGIDIDGNDIP---DEAPTLAVLA 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 326 TQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKS-ALKGNTVNSYGDHRIGMMLAIAGCIAEGK 404
Cdd:cd01556   307 AFAEGPTRIRNAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPlKGAGVEVYTYGDHRIAMSFAIAGLVAEGG 386

                         410       420
                  ....*....|....*....|...
gi 1943226393 405 TTIEDAEAVGVSYPTFFEELQKL 427
Cdd:cd01556   387 VTIEDPECVAKSFPNFFEDLESL 409
aroA TIGR01356
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents ...
 15-427 3.04e-153

3-phosphoshikimate 1-carboxyvinyltransferase; This model represents 3-phosphoshikimate-1-carboxyvinyltransferase (aroA), which catalyzes the sixth of seven steps in the shikimate pathway of the biosynthesis of chorimate. Chorismate is last common precursor of all three aromatic amino acids. Sequences scoring between the trusted and noise cutoffs include fragmentary and aberrant sequences in which generally well-conserved motifs are missing or altererd, but no example of a protein known to have a different function. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273574  Cd Length: 409  Bit Score: 439.79  E-value: 3.04e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  15 GNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDIVQNGDEVTVVGkglEGLQEPKAVLDVGNS 94
Cdd:TIGR01356   1 GEIRAPGSKSITHRALILAALAEGETRVRNLLRSEDTLATLDALRALGAKIEDGGEVAVIEG---VGGKEPQAELDLGNS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  95 GTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGTFTPLTIRGGDLKAIEYTSPVASAQVKSA 174
Cdd:TIGR01356  78 GTTARLLTGVLALADGEVVLTGDESLRKRPMGRLVDALRQLGAEISSLEGGGSLPLTISGPLPGGIVYISGSASSQYKSA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 175 ILLAG--LRAEGVTAVTEPHISRDHTERML---EAFGVKVTRE-GKTVKLAGGQKLTATDVQVPGDVSSAAFFLVAGAII 248
Cdd:TIGR01356 158 LLLAApaLQAVGITIVGEPLKSRPYIEITLdllGSFGVEVERSdGRKIVVPGGQKYGPQGYDVPGDYSSAAFFLAAAAIT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 249 PNsKLVLQNVGMNPTRTG--IIDVLEKMGATFTVEpinegasepAANITIET-SSLKGIEIGgdiIPRLIDEIPVIALAA 325
Cdd:TIGR01356 238 GG-RVTLENLGINPTQGDkaIIIVLEEMGADIEVE---------EDDLIVEGaSGLKGIKID---MDDMIDELPTLAVLA 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 326 TQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKSALKGNTVNSYGDHRIGMMLAIAGCIAEGKT 405
Cdd:TIGR01356 305 AFAEGVTRITGAEELRVKESDRIAAIAEELRKLGVDVEEFEDGLYIRGKKELKGAVVDTFGDHRIAMAFAVAGLVAEGEV 384

                         410       420
                  ....*....|....*....|..
gi 1943226393 406 TIEDAEAVGVSYPTFFEELQKL 427
Cdd:TIGR01356 385 LIDDPECVAKSFPSFFDVLERL 406
EPSP_synthase pfam00275
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
13-424 2.61e-138

EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);


Pssm-ID: 395213  Cd Length: 415  Bit Score: 402.06  E-value: 2.61e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  13 LNGNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDIV---QNGDEVTVVGKGLEGLQEPKAVL 89
Cdd:pfam00275   6 LSGEVKIPGSKSNSHRALILAALAAGESTITNLLDSDDTLTMLEALRALGAEIIkldDEKSVVIVEGLGGSFEAPEDLVL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  90 DVGNSGTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGTFTPLTIRGGDLKAIEYTSPVASA 169
Cdd:pfam00275  86 DMGNSGTALRPLTGRLALQSGEVVLPGDCSIGKRPMDRLLDALRQLGAEIEGREGYNYAPLKVRGLRLGGIHIDGDVSSQ 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 170 QVKSAILLAGLRAEGVTAVTE--PHISRDHTERMLEAFGVKVT--REGKTVKLAGGQKLTATDVQVPGDVSSAAFFLVAG 245
Cdd:pfam00275 166 FVTSLLMLAALLAEGTTTIENlaSEPYIDDTENMLKKFGAKIEgsGTELSITVKGGEKLPGQEYRVEGDRSSAAYFLVAA 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 246 AIIPnSKLVLQNVGMNPTRTG--IIDVLEKMGATFTVEPInegasepaANITIETSSLKGIEIggdIIPRLIDEIPVIAL 323
Cdd:pfam00275 246 AITG-GTVTVENVGINSLQGDeaLLEILEKMGAEITQEED--------ADIVVGPPGLRGKAV---DIRTAPDPAPTTAV 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 324 AATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIY-GKSALKGNTVNSYGDHRIGMMLAIAGCIAE 402
Cdd:pfam00275 314 LAAFAEGTTRIEGISELRVKETDRLFAMATELRRLGADVEELPDGLIIIpAVKELKGAEVDSYGDHRIAMALALAGLVAE 393

                         410       420
                  ....*....|....*....|..
gi 1943226393 403 GKTTIEDAEAVGVSYPTFFEEL 424
Cdd:pfam00275 394 GETIIDDIECTDRSFPDFEEKL 415
 
Name Accession Description Interval E-value
AroA COG0128
5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; ...
 1-427 0e+00

5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; 5-enolpyruvylshikimate-3-phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439898  Cd Length: 421  Bit Score: 575.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393   1 MKERTIQPvNNGLNGNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDI-VQNGDEVTVVGKGl 79
Cdd:COG0128     1 MSSLTIAP-PSPLKGTVRVPGSKSISHRALLLAALAEGESTIRNLLESDDTLATLEALRALGAEIeELDGGTLRVTGVG- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  80 EGLQEPKAVLDVGNSGTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGtFTPLTIRGGDLKA 159
Cdd:COG0128    79 GGLKEPDAVLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQLGARIESRGGG-YLPLTIRGGPLKG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 160 IEYTSP-VASAQVKSAILLAGLRAEG-----VTAVTEPHISRDHTERMLEAFGVKVTREG-KTVKLAGGQKLTATDVQVP 232
Cdd:COG0128   158 GEYEIPgSASSQFKSALLLAGPLAEGgleitVTGELESKPYRDHTERMLRAFGVEVEVEGyRRFTVPGGQRYRPGDYTVP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 233 GDVSSAAFFLVAGAIIpNSKLVLQNVGMNPT--RTGIIDVLEKMGATFTVEpiNEGasepaanITIETSSLKGIEIGGDI 310
Cdd:COG0128   238 GDISSAAFFLAAAAIT-GSEVTVEGVGLNSTqgDTGILDILKEMGADIEIE--NDG-------ITVRGSPLKGIDIDLSD 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 311 IPrliDEIPVIALAATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKSALKGNTVNSYGDHRI 390
Cdd:COG0128   308 IP---DEAPTLAVLAAFAEGTTRIRGAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPKLKGAEVDSYGDHRI 384

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1943226393 391 GMMLAIAGCIAEGKTTIEDAEAVGVSYPTFFEELQKL 427
Cdd:COG0128   385 AMAFAVAGLRAEGPVTIDDAECVAKSFPDFFELLESL 421
PRK02427 PRK02427
3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
 1-429 0e+00

3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 235037 [Multi-domain]  Cd Length: 435  Bit Score: 567.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393   1 MKERTIQPVNnGLNGNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDIVQngDEVTVVGKGLE 80
Cdd:PRK02427    2 MMMLLIIPPS-PLSGTVRVPGSKSISHRALLLAALAEGETTITNLLRSEDTLATLNALRALGVEIED--DEVVVEGVGGG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  81 GLQEPKAVLDVGNSGTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGtFTPLTIRGG-DLKA 159
Cdd:PRK02427   79 GLKEPEDVLDCGNSGTTMRLLTGLLALQPGEVVLTGDESLRKRPMGRLLDPLRQMGAKIEGRDEG-YLPLTIRGGkKGGP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 160 IEYTSPVASAQVKSAILLAGLRAEG--VTAVTEPHISRDHTE---RMLEAFGVKVTREG----KTVKLAGGQKLTATDVQ 230
Cdd:PRK02427  158 IEYDGPVSSQFVKSLLLLAPLFAEGdtETTVIEPLPSRPHTEitlRMLRAFGVEVENVEgwgyRRIVIKGGQRLRGQDIT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 231 VPGDVSSAAFFLVAGAIIPNSKLVLQNVGMNPTRTG--IIDVLEKMGATFTVEPINEGaSEPAANITIETSSLKGIEIGg 308
Cdd:PRK02427  238 VPGDPSSAAFFLAAAAITGGSEVTITNVGLNSTQGGkaIIDVLEKMGADIEIENEREG-GEPVGDIRVRSSELKGIDID- 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 309 diIPRLIDEIPVIALAATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKSalKGNTVNSYGDH 388
Cdd:PRK02427  316 --IPDIIDEAPTLAVLAAFAEGTTVIRNAEELRVKETDRIAAMATELRKLGAEVEETEDGLIITGGP--LAGVVDSYGDH 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1943226393 389 RIGMMLAIAGCIAEGKTTIEDAEAVGVSYPTFFEELQKLAK 429
Cdd:PRK02427  392 RIAMAFAIAGLAAEGPVTIDDPECVAKSFPDFFEDLASLGA 432
EPSP_synthase cd01556
EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase ...
 13-427 2.17e-178

EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-phosphate (EPSP), an intermediate in the shikimate pathway leading to aromatic amino acid biosynthesis. The reaction is phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. It is found in bacteria and plants but not animals. The enzyme is the target of the widely used herbicide glyphosate, which has been shown to occupy the active site. In bacteria and plants, it is a single domain protein, while in fungi, the domain is found as part of a multidomain protein with functions that are all part of the shikimate pathway.


Pssm-ID: 238797  Cd Length: 409  Bit Score: 503.63  E-value: 2.17e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  13 LNGNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDIVQNGDEVTVVGKGLeGLQEPKAVLDVG 92
Cdd:cd01556     1 LSGEITVPGSKSISHRALLLAALAEGESRIENLLDSDDTLATLEALRALGAKIEEEGGTVEIVGGGG-LGLPPEAVLDCG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  93 NSGTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGTFTPLtIRGGDLKAIEYTSPVA-SAQV 171
Cdd:cd01556    80 NSGTTMRLLTGLLALQGGDSVLTGDESLRKRPMGRLVDALRQLGAEIEGREGGGYPPL-IGGGGLKGGEVEIPGAvSSQF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 172 KSAILLAGLRAEGVTAVT----EPHISRDHTERMLEAFGVKVTREG-KTVKLAGGQKLTATDVQVPGDVSSAAFFLVAGA 246
Cdd:cd01556   159 KSALLLAAPLAEGPTTIIigelESKPYIDHTERMLRAFGAEVEVDGyRTITVKGGQKYKGPEYTVEGDASSAAFFLAAAA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 247 IIPnSKLVLQNVGMNPTRTGIIDVLEKMGATFTVEPINEgasepaanITIE-TSSLKGIEIGGDIIPrliDEIPVIALAA 325
Cdd:cd01556   239 ITG-SEIVIKNVGLNSGDTGIIDVLKEMGADIEIGNEDT--------VVVEsGGKLKGIDIDGNDIP---DEAPTLAVLA 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 326 TQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKS-ALKGNTVNSYGDHRIGMMLAIAGCIAEGK 404
Cdd:cd01556   307 AFAEGPTRIRNAAELRVKESDRIAAMATELRKLGADVEETEDGLIIEGGPlKGAGVEVYTYGDHRIAMSFAIAGLVAEGG 386

                         410       420
                  ....*....|....*....|...
gi 1943226393 405 TTIEDAEAVGVSYPTFFEELQKL 427
Cdd:cd01556   387 VTIEDPECVAKSFPNFFEDLESL 409
PRK14806 PRK14806
bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; ...
 5-422 3.84e-165

bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 237820 [Multi-domain]  Cd Length: 735  Bit Score: 481.80  E-value: 3.84e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393   5 TIQPvNNGLNGNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDI--VQNGdEVTVVGKGLEGL 82
Cdd:PRK14806  305 SVLP-GGAVKGTIRVPGDKSISHRSIMLGSLAEGVTEVEGFLEGEDALATLQAFRDMGVVIegPHNG-RVTIHGVGLHGL 382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  83 QEPKAVLDVGNSGTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGTfTPLTIRGGD-LKAIE 161
Cdd:PRK14806  383 KAPPGPLYMGNSGTSMRLLSGLLAAQSFDSVLTGDASLSKRPMERVAKPLREMGAVIETGEEGR-PPLSIRGGQrLKGIH 461

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 162 YTSPVASAQVKSAILLAGLRAEGVTAVTEPHISRDHTERMLEAFGVKVTREGKTVKLAGGQKLTATDVQVPGDVSSAAFF 241
Cdd:PRK14806  462 YDLPMASAQVKSCLLLAGLYAEGETSVTEPAPTRDHTERMLRGFGYPVKVEGNTISVEGGGKLTATDIEVPADISSAAFF 541

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 242 LVAGAIIPNSKLVLQNVGMNPTRTGIIDVLEKMGATFTVEPINEGASEPAANITIETSSLKGIEIGGDIIPRLIDEIPVI 321
Cdd:PRK14806  542 LVAASIAEGSELTLEHVGINPTRTGVIDILKLMGADITLENEREVGGEPVADIRVRGARLKGIDIPEDQVPLAIDEFPVL 621

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 322 ALAATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKSaLKGNTVNSYGDHRIGMMLAIAGCIA 401
Cdd:PRK14806  622 FVAAACAEGRTVLTGAEELRVKESDRIQVMADGLKTLGIDCEPTPDGIIIEGGI-FGGGEVESHGDHRIAMSFSVASLRA 700

                         410       420
                  ....*....|....*....|.
gi 1943226393 402 EGKTTIEDAEAVGVSYPTFFE 422
Cdd:PRK14806  701 SGPITIHDCANVATSFPNFLE 721
aroA TIGR01356
3-phosphoshikimate 1-carboxyvinyltransferase; This model represents ...
 15-427 3.04e-153

3-phosphoshikimate 1-carboxyvinyltransferase; This model represents 3-phosphoshikimate-1-carboxyvinyltransferase (aroA), which catalyzes the sixth of seven steps in the shikimate pathway of the biosynthesis of chorimate. Chorismate is last common precursor of all three aromatic amino acids. Sequences scoring between the trusted and noise cutoffs include fragmentary and aberrant sequences in which generally well-conserved motifs are missing or altererd, but no example of a protein known to have a different function. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273574  Cd Length: 409  Bit Score: 439.79  E-value: 3.04e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  15 GNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDIVQNGDEVTVVGkglEGLQEPKAVLDVGNS 94
Cdd:TIGR01356   1 GEIRAPGSKSITHRALILAALAEGETRVRNLLRSEDTLATLDALRALGAKIEDGGEVAVIEG---VGGKEPQAELDLGNS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  95 GTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGTFTPLTIRGGDLKAIEYTSPVASAQVKSA 174
Cdd:TIGR01356  78 GTTARLLTGVLALADGEVVLTGDESLRKRPMGRLVDALRQLGAEISSLEGGGSLPLTISGPLPGGIVYISGSASSQYKSA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 175 ILLAG--LRAEGVTAVTEPHISRDHTERML---EAFGVKVTRE-GKTVKLAGGQKLTATDVQVPGDVSSAAFFLVAGAII 248
Cdd:TIGR01356 158 LLLAApaLQAVGITIVGEPLKSRPYIEITLdllGSFGVEVERSdGRKIVVPGGQKYGPQGYDVPGDYSSAAFFLAAAAIT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 249 PNsKLVLQNVGMNPTRTG--IIDVLEKMGATFTVEpinegasepAANITIET-SSLKGIEIGgdiIPRLIDEIPVIALAA 325
Cdd:TIGR01356 238 GG-RVTLENLGINPTQGDkaIIIVLEEMGADIEVE---------EDDLIVEGaSGLKGIKID---MDDMIDELPTLAVLA 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 326 TQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKSALKGNTVNSYGDHRIGMMLAIAGCIAEGKT 405
Cdd:TIGR01356 305 AFAEGVTRITGAEELRVKESDRIAAIAEELRKLGVDVEEFEDGLYIRGKKELKGAVVDTFGDHRIAMAFAVAGLVAEGEV 384

                         410       420
                  ....*....|....*....|..
gi 1943226393 406 TIEDAEAVGVSYPTFFEELQKL 427
Cdd:TIGR01356 385 LIDDPECVAKSFPSFFDVLERL 406
EPSP_synthase pfam00275
EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);
13-424 2.61e-138

EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase);


Pssm-ID: 395213  Cd Length: 415  Bit Score: 402.06  E-value: 2.61e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  13 LNGNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDIV---QNGDEVTVVGKGLEGLQEPKAVL 89
Cdd:pfam00275   6 LSGEVKIPGSKSNSHRALILAALAAGESTITNLLDSDDTLTMLEALRALGAEIIkldDEKSVVIVEGLGGSFEAPEDLVL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  90 DVGNSGTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGTFTPLTIRGGDLKAIEYTSPVASA 169
Cdd:pfam00275  86 DMGNSGTALRPLTGRLALQSGEVVLPGDCSIGKRPMDRLLDALRQLGAEIEGREGYNYAPLKVRGLRLGGIHIDGDVSSQ 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 170 QVKSAILLAGLRAEGVTAVTE--PHISRDHTERMLEAFGVKVT--REGKTVKLAGGQKLTATDVQVPGDVSSAAFFLVAG 245
Cdd:pfam00275 166 FVTSLLMLAALLAEGTTTIENlaSEPYIDDTENMLKKFGAKIEgsGTELSITVKGGEKLPGQEYRVEGDRSSAAYFLVAA 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 246 AIIPnSKLVLQNVGMNPTRTG--IIDVLEKMGATFTVEPInegasepaANITIETSSLKGIEIggdIIPRLIDEIPVIAL 323
Cdd:pfam00275 246 AITG-GTVTVENVGINSLQGDeaLLEILEKMGAEITQEED--------ADIVVGPPGLRGKAV---DIRTAPDPAPTTAV 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 324 AATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIY-GKSALKGNTVNSYGDHRIGMMLAIAGCIAE 402
Cdd:pfam00275 314 LAAFAEGTTRIEGISELRVKETDRLFAMATELRRLGADVEELPDGLIIIpAVKELKGAEVDSYGDHRIAMALALAGLVAE 393

                         410       420
                  ....*....|....*....|..
gi 1943226393 403 GKTTIEDAEAVGVSYPTFFEEL 424
Cdd:pfam00275 394 GETIIDDIECTDRSFPDFEEKL 415
EPT-like cd01554
Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine ...
 13-427 6.37e-123

Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer.


Pssm-ID: 238795  Cd Length: 408  Bit Score: 362.69  E-value: 6.37e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  13 LNGNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDIVQNGDEVTVVGKGLEGLQEPKAVLDVG 92
Cdd:cd01554     1 LHGIIRVPGDKSISHRSLIFASLAEGETKVYNILRGEDVLSTMQVLRDLGVEIEDKDGVITIQGVGMAGLKAPQNALNLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  93 NSGTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGTFTPLTIRGGDLKAIEYTSPVASAQVK 172
Cdd:cd01554    81 NSGTAIRLISGVLAGADFEVELFGDDSLSKRPMDRVTLPLKKMGASISGQEERDLPPLLKGGKNLGPIHYEDPIASAQVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 173 SAILLAGLRAEGVT----AVTEPHIsrDHTERMLEAFGVKVTREG-KTVKLAGGQKLTATDVQVPGDVSSAAFFLVAGAI 247
Cdd:cd01554   161 SALMFAALLAKGETviieAAKEPTI--NHTENMLQTFGGHISVQGtKKIVVQGPQKLTGQKYVVPGDISSAAFFLVAAAI 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 248 IPnSKLVLQNVGMNPTRTGIIDVLEKMGATFTVEpinegasepAANITIETSSLKGIEIGGDIIPRLIDEIPVIALAATQ 327
Cdd:cd01554   239 AP-GRLVLQNVGINETRTGIIDVLRAMGAKIEIG---------EDTISVESSDLKATEICGALIPRLIDELPIIALLALQ 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 328 AEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKSALKGNTVNSYGDHRIGMMLAIAGCIAEGKTTI 407
Cdd:cd01554   309 AQGTTVIKDAEELKVKETDRIFVVADELNSMGADIEPTADGMIIKGKEKLHGARVNTFGDHRIGMMTALAALVADGEVEL 388

                         410       420
                  ....*....|....*....|
gi 1943226393 408 EDAEAVGVSYPTFFEELQKL 427
Cdd:cd01554   389 DRAEAINTSYPSFFDDLESL 408
PLN02338 PLN02338
3-phosphoshikimate 1-carboxyvinyltransferase
 1-429 7.62e-53

3-phosphoshikimate 1-carboxyvinyltransferase


Pssm-ID: 177972 [Multi-domain]  Cd Length: 443  Bit Score: 183.03  E-value: 7.62e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393   1 MKERTIQPVNNgLNGNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDIVQNGD--EVTVVGKG 78
Cdd:PLN02338    1 AEEITLQPIKE-ISGTVKLPGSKSLSNRILLLAALSEGTTVVDNLLDSDDIRYMLGALKTLGLNVEEDSEnnRAVVEGCG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  79 ----LEGLQEPKAVLDVGNSGTTIRLMSGILA----NTPFFscVQGDASIAKRPMKRVTNPLKQMGANIDGREEGTFTPL 150
Cdd:PLN02338   80 gkfpVSGDSKEDVELFLGNAGTAMRPLTAAVTaaggNASYV--LDGVPRMRERPIGDLVDGLKQLGADVECTLGTNCPPV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 151 TIRG-GDLKAIE-YTSPVASAQVKSAILLAGLRAEGVTA-------VTEPHIsrDHTERMLEAFGVKVTREG--KTVKLA 219
Cdd:PLN02338  158 RVNAaGGLPGGKvKLSGSISSQYLTALLMAAPLALGDVEieivdklISVPYV--EMTLKLMERFGVSVEHSDswDRFFIK 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 220 GGQKLTAT-DVQVPGDVSSAAFFLvAGAIIPNSKLVLQNVGMNPTR--TGIIDVLEKMGATFTVEPINEGASEPAANITI 296
Cdd:PLN02338  236 GGQKYKSPgNAYVEGDASSASYFL-AGAAITGGTVTVEGCGTTSLQgdVKFAEVLEKMGAKVEWTENSVTVTGPPRDAFG 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 297 ETSsLKGIEIGGDIIPrliDEIPVIALAATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKSA 376
Cdd:PLN02338  315 GKH-LKAIDVNMNKMP---DVAMTLAVVALFADGPTAIRDVASWRVKETERMIAICTELRKLGATVEEGPDYCIITPPKK 390

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1943226393 377 LKGNTVNSYGDHRIGMMLAIAGCiAEGKTTIEDAEAVGVSYPTFFEELQKLAK 429
Cdd:PLN02338  391 LKPAEIDTYDDHRMAMAFSLAAC-GDVPVTINDPGCTRKTFPTYFDVLESIAK 442
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
12-429 1.24e-48

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 175.62  E-value: 1.24e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  12 GLNGNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDIVQNGDEVTVVGKGLEgLQEPKAVLDV 91
Cdd:PRK11860   14 SAGGTVRLPGSKSISNRVLLLAALSEGTTTVRDLLDSDDTRVMLDALRALGCGVEQLGDTYRITGLGGQ-FPVKQADLFL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  92 GNSGTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGTFTPLTIRGGDLKAieyTSPVA---- 167
Cdd:PRK11860   93 GNAGTAMRPLTAALALLGGEYELSGVPRMHERPIGDLVDALRQLGCDIDYLGNEGFPPLRIGPAPLRL---DAPIRvrgd 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 168 -SAQVKSAILLAGLRAEGVTAVTE---PHISRDHTE---RMLEAFGVKVTREG--KTVKLAGGQKLTATDVQVPGDVSSA 238
Cdd:PRK11860  170 vSSQFLTALLMALPLVARRDITIEvvgELISKPYIEitlNLLARFGIAVQREGwqRFTIPAGSRYRSPGEIHVEGDASSA 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 239 AFFLVAGAIIPNSKLVLQNVGMNPTRTGI--IDVLEKMGATFTVEPINEGASEPAAnitietsSLKGIEIGGDIIPrliD 316
Cdd:PRK11860  250 SYFIAAGAIAGGAPVRIEGVGRDSIQGDIrfAEAARAMGAQVTSGPNWLEVRRGAW-------PLKAIDLDCNHIP---D 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 317 EIPVIALAATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIY---GKSALKGNTVNSYGDHRIGMM 393
Cdd:PRK11860  320 AAMTLAVMALYADGTTTLRNIASWRVKETDRIAAMATELRKLGATVEEGADYIRVTppaQAADWKAAAIHTYDDHRMAMC 399

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1943226393 394 LAIAGC-IAEGKTTIEDAEAVGVSYPTFFEELQKLAK 429
Cdd:PRK11860  400 FSLAAFnPAGLPVRINDPKCVAKTFPDYFEALFSVAQ 436
PRK11861 PRK11861
bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional
 15-428 8.62e-39

bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional


Pssm-ID: 183343 [Multi-domain]  Cd Length: 673  Bit Score: 148.32  E-value: 8.62e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  15 GNITIPGDKSISHRAVMFGAIAEGKTTIKGFLPGADCLSTISCFKEMGVDIVQNGDeVTVVGKGLEGLQEPKAVLDVGNS 94
Cdd:PRK11861  253 GTVRLPGSKSISNRVLLLAALAEGETTVTNLLDSDDTRVMLDALTKLGVKLSRDGG-TCVVGGTRGAFTAKTADLFLGNA 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  95 GTTIRLMSGILANTPFFSCVQGDASIAKRPMKRVTNPLKQMGANIDGREEGTFTPLTIRGGdlkAIEYTSPV-----ASA 169
Cdd:PRK11861  332 GTAVRPLTAALAVNGGEYRIHGVPRMHERPIGDLVDGLRQIGARIDYEGNEGFPPLRIRPA---TISVDAPIrvrgdVSS 408

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 170 QVKSAIL--LAGLRAEGVTAVTEPH---ISRDHTE---RMLEAFGVKVTREG--KTVKLAGGQKLTATDVQVPGDVSSAA 239
Cdd:PRK11861  409 QFLTALLmtLPLVKAKDGASVVEIDgelISKPYIEitiKLMARFGVTVERDGwqRFTVPAGVRYRSPGTIMVEGDASSAS 488

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 240 FFLVAGAiIPNSKLVLQNVGMNPTR--TGIIDVLEKMGATFTvepINEGASEpAANITIETSSLKGIEIGGDIIPrliDE 317
Cdd:PRK11861  489 YFLAAGA-LGGGPLRVEGVGRASIQgdVGFANALMQMGANVT---MGDDWIE-VRGIGHDHGRLAPIDMDFNLIP---DA 560

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 318 IPVIALAATQAEGITVIKDAHELKVKETNRIDTVVAELTKLGARIEATDDGMIIYGKSALKGN-TVNSYGDHRIGMMLAI 396
Cdd:PRK11861  561 AMTIAVAALFADGPSTLRNIGSWRVKETDRIAAMATELRKVGATVEEGADYLVVTPPAQLTPNaSIDTYDDHRMAMCFSL 640

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1943226393 397 AGcIAEGKTTIEDAEAVGVSYPTFFEELQKLA 428
Cdd:PRK11861  641 VS-LGGVPVRINDPKCVGKTFPDYFDRFLALA 671
UdpNAET cd01555
UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the ...
 13-427 6.09e-24

UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine. This enzyme is of interest as a potential target for anti-bacterial agents. The only other known enolpyruvyl transferase is the related 5-enolpyruvylshikimate-3-phosphate synthase.


Pssm-ID: 238796  Cd Length: 400  Bit Score: 102.55  E-value: 6.09e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  13 LNGNITIPGDKSiSHRAVMFGAI-AEGKTTIKGfLPG-ADCLSTISCFKEMGVDIVQNGDEVTVVGKGLEGLQEPKAVLd 90
Cdd:cd01555     1 LSGEVRISGAKN-AALPILAAALlTDEPVTLRN-VPDlLDVETMIELLRSLGAKVEFEGENTLVIDASNINSTEAPYEL- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  91 VGNSGTTIRLMSGILA--NTPFFSCVQGDAsIAKRPMKRVTNPLKQMGANIdgREEGTFTPLTIRGGdLKAIEYTSPVAS 168
Cdd:cd01555    78 VRKMRASILVLGPLLArfGEARVSLPGGCA-IGARPVDLHLKGLEALGAKI--EIEDGYVEAKAAGR-LKGARIYLDFPS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 169 AQVKSAILLAGLRAEGVT----AVTEPHISRdhTERMLEAFGVKVTREG-KTVKLAGGQKLTATDVQVPGDVSSAAFFLV 243
Cdd:cd01555   154 VGATENIMMAAVLAEGTTvienAAREPEIVD--LANFLNKMGAKIEGAGtDTIRIEGVERLHGAEHTVIPDRIEAGTFLV 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 244 AGAIIpNSKLVLQNVGMNPTRTgIIDVLEKMGATFTVEpinegasEPAANITIETSSLKGIEIGGDIIPRLI-DEIPVIA 322
Cdd:cd01555   232 AAAIT-GGDITVENVIPEHLEA-VLAKLREMGAKIEIG-------EDGIRVDGDGGRLKAVDIETAPYPGFPtDLQAQFM 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 323 LAATQAEGITVIKDahelKVKEtNRIdTVVAELTKLGARIEATDDGMIIYGKSALKGNTVNSyGDHRIGMMLAIAGCIAE 402
Cdd:cd01555   303 ALLTQAEGTSVITE----TIFE-NRF-MHVDELNRMGADIKVEGNTAIIRGVTKLSGAPVMA-TDLRAGAALVLAGLAAE 375

                         410       420
                  ....*....|....*....|....*
gi 1943226393 403 GKTTIEDAEAVGVSYPTFFEELQKL 427
Cdd:cd01555   376 GETIISNIYHIDRGYERIEEKLRAL 400
MurA COG0766
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ...
 132-411 1.55e-20

UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440529  Cd Length: 416  Bit Score: 93.13  E-value: 1.55e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 132 LKQMGANIDgREEGTFTpltIRGGDLKAIEYTSPVASAQVKSAILLAGLRAEGVT----AVTEPHIsrDHTERMLEAFGV 207
Cdd:COG0766   131 LEALGAEIE-IEHGYIE---ARAGRLKGARIYLDFPSVGATENIMMAAVLAEGTTvienAAREPEI--VDLANFLNAMGA 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 208 KVTREG-KTVKLAGGQKLTATDVQVPGDVSSAAFFLVAGAIIpNSKLVLQNVGMNPTRTgIIDVLEKMGATFTVEPinEG 286
Cdd:COG0766   205 KIEGAGtDTITIEGVEKLHGAEHTVIPDRIEAGTFLVAAAIT-GGDVTVKNVIPEHLEA-VLAKLREAGVEIEEGD--DG 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 287 asepaanITIE-TSSLKGIEI------GgdiIPrlIDEIPVIALAATQAEGITVIkdaHElKVKEtNRIdTVVAELTKLG 359
Cdd:COG0766   281 -------IRVRgPGRLKAVDIktapypG---FP--TDLQAQFMALLTQAEGTSVI---TE-TVFE-NRF-MHVDELNRMG 342

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1943226393 360 ARIEATDDGMIIYGKSALKGNTVNSyGDHRIGMMLAIAGCIAEGKTTIEDAE 411
Cdd:COG0766   343 ADIKLDGHTAIVRGVTKLSGAPVMA-TDLRAGAALVLAGLAAEGETVIDNIY 393
PRK09369 PRK09369
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
 132-411 1.18e-16

UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated


Pssm-ID: 236486  Cd Length: 417  Bit Score: 81.23  E-value: 1.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 132 LKQMGANIDgrEEGTFTPLTIRGGdLKAIEYTSPVAS----AQvksaILLAGLRAEGVT----AVTEPHISrDhTERMLE 203
Cdd:PRK09369  131 LEALGAEIE--IEHGYVEAKADGR-LKGAHIVLDFPSvgatEN----ILMAAVLAEGTTvienAAREPEIV-D-LANFLN 201

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 204 AFGVKVTREG-KTVKLAGGQKLTATDVQVPGDVSSAAFFLVAGAIIpNSKLVLQNVGMNPTRTgIIDVLEKMGATFTVEP 282
Cdd:PRK09369  202 KMGAKISGAGtDTITIEGVERLHGAEHTVIPDRIEAGTFLVAAAIT-GGDVTIRGARPEHLEA-VLAKLREAGAEIEEGE 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 283 inegasepaanitietsslKGIEIGGDIIPRLIDeI--------------PVIALAaTQAEGITVIkdaHElKVKEtNRI 348
Cdd:PRK09369  280 -------------------DGIRVDMPGRLKAVD-IktapypgfptdmqaQFMALL-TQAEGTSVI---TE-TIFE-NRF 333

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1943226393 349 dTVVAELTKLGARIEATDDGMIIYGKSALKGNTVNSyGDHRIGMMLAIAGCIAEGKTTIEDAE 411
Cdd:PRK09369  334 -MHVPELIRMGADIEVDGHTAVVRGVEKLSGAPVMA-TDLRASASLVLAGLVAEGTTIVDRIY 394
PRK12830 PRK12830
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Reviewed
 13-427 1.83e-11

UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Reviewed


Pssm-ID: 183779  Cd Length: 417  Bit Score: 65.26  E-value: 1.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  13 LNGNITIPGDKSiSHRAVMFGAI-AEGKTTIKGfLPG-ADCLSTISCFKEMGVDIVQNGDEVTVVGKGLEGLQEPKAvlD 90
Cdd:PRK12830   12 LSGEVTISGAKN-SAVALIPAAIlADGPVTLDG-VPDiSDVHSLVDILEELGGKVKRDGDTLEIDPTGIQSMPLPNG--K 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  91 VGNSGTTIRLMSGILANtpFFSCV---QGDASIAKRPMKRVTNPLKQMGANIDGREEGTFtpltIRGGDLKAIEYTSPVA 167
Cdd:PRK12830   88 VKSLRASYYFMGALLGR--FKKAVvglPGGCDLGPRPIDQHIKGFEALGAEVTNEGGAIY----LKADELKGAHIYLDVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 168 SAQVKSAILLAGLRAEGVT----AVTEPHISRDHTerMLEAFGVKVTREG-KTVKLAGGQKLTATDVQVPGDVSSAAFFL 242
Cdd:PRK12830  162 SVGATINIMLAAVKAKGRTvienAAKEPEIIDVAT--LLNNMGANIKGAGtDVIRIEGVDELHGCRHTVIPDRIEAGTYM 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 243 VAGAIIpNSKLVLQNVgmNPTR-TGIIDVLEKMGATFTVEpinegasepAANITIETSS-LKGIEIGGDIIPRLIDEI-- 318
Cdd:PRK12830  240 ILAAAC-GGGVTINNV--IPEHlESFIAKLEEMGVRVEVN---------EDSIFVEKQGnLKAVDIKTLPYPGFATDLqq 307

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 319 PVIALAaTQAEGITVIKDA-HELKVKEtnridtvVAELTKLGARIEATDDGMIIYGKSALKGNTVNSyGDHRIGMMLAIA 397
Cdd:PRK12830  308 PLTPLL-LKANGRSVVTDTiYEKRFKH-------VDELKRMGANIKVEGRSAIITGPSKLTGAKVKA-TDLRAGAALVIA 378

                         410       420       430
                  ....*....|....*....|....*....|
gi 1943226393 398 GCIAEGKTTIEDAEAVGVSYPTFFEELQKL 427
Cdd:PRK12830  379 GLMAEGVTEITNIEHIDRGYSNIIEKLKAL 408
MurA COG0766
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ...
 268-412 2.33e-07

UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440529  Cd Length: 416  Bit Score: 52.68  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 268 IDVLEKMGATFTVEpinEGasepaaNITIETSSLKGIEIggdiiprLIDEIPV-----IALAATQAEGITVIKDAHelkv 342
Cdd:COG0766   128 LKGLEALGAEIEIE---HG------YIEARAGRLKGARI-------YLDFPSVgatenIMMAAVLAEGTTVIENAA---- 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1943226393 343 KETNRIDtvVAE-LTKLGARIE-ATDDGMIIYGKSALKGntvnsyGDHRIG------MMLAIAGCIAEGKTTIEDAEA 412
Cdd:COG0766   188 REPEIVD--LANfLNAMGAKIEgAGTDTITIEGVEKLHG------AEHTVIpdrieaGTFLVAAAITGGDVTVKNVIP 257
MurA COG0766
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ...
 132-363 7.73e-07

UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440529  Cd Length: 416  Bit Score: 51.14  E-value: 7.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 132 LKQMGANIDGreEGTFTpLTIRGGD-LKAIEYT-SP---------VASAQVKSAILLAGLRAEGVTAVTEphisrdhter 200
Cdd:COG0766   199 LNAMGAKIEG--AGTDT-ITIEGVEkLHGAEHTvIPdrieagtflVAAAITGGDVTVKNVIPEHLEAVLA---------- 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 201 MLEAFGVKVTREGKTVKLAGGQKLTATDVQV---PG---DVssAAFFLVAGAIIPNSKLVLQNVgmNPTRTGIIDVLEKM 274
Cdd:COG0766   266 KLREAGVEIEEGDDGIRVRGPGRLKAVDIKTapyPGfptDL--QAQFMALLTQAEGTSVITETV--FENRFMHVDELNRM 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 275 GATFTVEPinegasepaANITIE-TSSLKGIEI-GGDIipR----LIdeipviaLAATQAEGITVIKDAHELkvketNR- 347
Cdd:COG0766   342 GADIKLDG---------HTAIVRgVTKLSGAPVmATDL--RagaaLV-------LAGLAAEGETVIDNIYHI-----DRg 398

                         250
                  ....*....|....*.
gi 1943226393 348 IDTVVAELTKLGARIE 363
Cdd:COG0766   399 YENLEEKLRALGADIE 414
PRK09369 PRK09369
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
 268-412 1.49e-06

UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated


Pssm-ID: 236486  Cd Length: 417  Bit Score: 50.03  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 268 IDVLEKMGATFTVEpinEGasepaaNITIETSS-LKGIEIggdiiprLIDEIPV-----IALAATQAEGITVIKDAhelk 341
Cdd:PRK09369  128 LKGLEALGAEIEIE---HG------YVEAKADGrLKGAHI-------VLDFPSVgatenILMAAVLAEGTTVIENA---- 187

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1943226393 342 VKETNRIDTvvAE-LTKLGARIE-ATDDGMIIYGKSALKGntvnsyGDHRIG--MM----LAIAGCIAEGKTTIEDAEA 412
Cdd:PRK09369  188 AREPEIVDL--ANfLNKMGAKISgAGTDTITIEGVERLHG------AEHTVIpdRIeagtFLVAAAITGGDVTIRGARP 258
MurA COG0766
UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; ...
 33-212 1.99e-05

UDP-N-acetylglucosamine enolpyruvyl transferase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylglucosamine enolpyruvyl transferase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440529  Cd Length: 416  Bit Score: 46.52  E-value: 1.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  33 GAIAEGKTTIKGFLPgaDCL-STISCFKEMGVDIVQNGDEVTVVGKGleglqEPKAVldvgnsgtTIR----------LM 101
Cdd:COG0766   243 AAITGGDVTVKNVIP--EHLeAVLAKLREAGVEIEEGDDGIRVRGPG-----RLKAV--------DIKtapypgfptdLQ 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 102 SGILAntpFFSCVQGDASIA-----KRPMkrVTNPLKQMGANI--DGREegtftpLTIRGGD-LKAIEYTSPV--ASAqv 171
Cdd:COG0766   308 AQFMA---LLTQAEGTSVITetvfeNRFM--HVDELNRMGADIklDGHT------AIVRGVTkLSGAPVMATDlrAGA-- 374

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1943226393 172 ksAILLAGLRAEGVTAVTEP-HISR--DHTERMLEAFGVKVTRE 212
Cdd:COG0766   375 --ALVLAGLAAEGETVIDNIyHIDRgyENLEEKLRALGADIERV 416
PRK09369 PRK09369
UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
 33-212 2.45e-03

UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated


Pssm-ID: 236486  Cd Length: 417  Bit Score: 40.01  E-value: 2.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393  33 GAIAEGKTTIKGFLPgADCLSTISCFKEMGVDIVQNGDEVTVVGKGleglqEPKAVldvgnsgtTIR----------LMS 102
Cdd:PRK09369  244 AAITGGDVTIRGARP-EHLEAVLAKLREAGAEIEEGEDGIRVDMPG-----RLKAV--------DIKtapypgfptdMQA 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1943226393 103 GILAntpFFSCVQGDASIA-----KRPMKrvTNPLKQMGANI--DGREegtftpLTIRGGD-LKAIEYTSP--VASAqvk 172
Cdd:PRK09369  310 QFMA---LLTQAEGTSVITetifeNRFMH--VPELIRMGADIevDGHT------AVVRGVEkLSGAPVMATdlRASA--- 375

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1943226393 173 sAILLAGLRAEGVTAVTE-PHISR--DHTERMLEAFGVKVTRE 212
Cdd:PRK09369  376 -SLVLAGLVAEGTTIVDRiYHLDRgyERIEEKLRALGADIERV 417
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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