|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
4-648 |
0e+00 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 952.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 4 KYLVIVESPAKAKTIEKYLGRNYKVMASVGHIRDLPKSKMGIDVENNYEPHYISIRGKGDVIKSLKSAAKKAQKVYLASD 83
Cdd:PRK06599 3 KKLVIVESPAKAKTIKKYLGKDYKVLASFGHVRDLPKKKGGVDPDNDFAPKYEIIEGKEKVVDALKKAAKKADAVYLATD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 84 PDREGEAIAWHLAYLLGLDLSEK---NRVVFNEITKEAVKAAFKEPRTIDVDLVDAQQARRALDRLVGYSISPILWRKVK 160
Cdd:PRK06599 83 PDREGEAIAWHIAEVLKEAKLKDknvKRVVFNEITKKAVQEAIENPRDIDMDLVDAQQARRALDYLVGFKLSPLLWKKVR 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 161 KGLSAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNF-KKTRKKFKANFWGIDGKK---KKLPDAQSVKEVTDRIDGPD 236
Cdd:PRK06599 163 RGLSAGRVQSVALRLICEREDEIEAFIPQEYWTIEADLaTSNGEPFTAKLVEVNGKKlekFSITNEEQAKALVKALEGQA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 237 FTVQKVEKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGISLGKqGTVGLITYMRTDSTRIAETAKAEAA 316
Cdd:PRK06599 243 YTVDKIEKKERKRNPPPPFITSTLQQEASRKLGFSAKKTMRIAQKLYEGIDLGE-GTVGLITYMRTDSVRLSNEALDEAR 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 317 TFIEETYGKEFSSHAQRKIKN-AQGAQDAHEAVRPTSVLRTPEEIKQYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVT 395
Cdd:PRK06599 322 KYITKKYGKEYLPAKPRVYKKkSKNAQEAHEAIRPTSINRTPESLKPYLTPDQFKLYELIWKRTVASQMAPAILDQTSVD 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 396 LE--QNGVLFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELAQGDIVQSVDIEPKQHFTQPPARFSEATLIRALEEN 473
Cdd:PRK06599 402 IAseNGKYVFRATGSVILFPGFLKVYGESKDDEEEDDEKLLPPLKEGEKLKLDELLPEQHFTEPPPRYSEASLVKKLEEY 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 474 GVGRPSTYAPTLDTIQRRYYVKLTQKRFEPTELGEIVNSLICDFFPQIVDIHFTAEMEGDLDKIEEGKEAWIEVVDRFYK 553
Cdd:PRK06599 482 GIGRPSTYASIISTLQDREYVELEKKRFIPTDLGRIVNDFLVEHFPKYVDYDFTAGLEDELDEIAEGKKDWKPVLREFWE 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 554 PFEKELTNAEEKIEKIQIKDEPAGFDCDIC-GHPMVIKLGKYGKFYACSNFPDCRNTKPI-----------VKEIGVTCP 621
Cdd:PRK06599 562 PFISNLEKVEEDVRTEKVTQEETDETCPKCgGGPLVLKLGKNGKFLGCSGYPECKYTKNItrdedepieeeEIVEEEKCP 641
|
650 660
....*....|....*....|....*....
gi 1948584369 622 VCHEGQVIerksKKNR--IFYGCSRFPDC 648
Cdd:PRK06599 642 KCGGPLVL----KKGRygKFLACSGYPEC 666
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
4-559 |
0e+00 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 863.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 4 KYLVIVESPAKAKTIEKYLGRNYKVMASVGHIRDLPKSKMGIDVENNYEPHYISIRGKGDVIKSLKSAAKKAQKVYLASD 83
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYLGKDYVVTASVGHLRDLPKPELDVDVENDFEPKYEVIPGKKKQVKELKKLAKKADEVILATD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 84 PDREGEAIAWHLAYLLGlDLSEKNRVVFNEITKEAVKAAFKEPRTIDVDLVDAQQARRALDRLVGYSISPILWRKVKKGL 163
Cdd:COG0550 81 PDREGEAIAWHLLELLG-DKKPVKRVVFNEITKKAIKEAFKNPRDIDMNLVDAQQARRILDRLVGYNLSPLLWKKVKRGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 164 SAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRKKFKANFWGIDGKKkkLPDAQSVKEVTDRIDGPDFTVQKVE 243
Cdd:COG0550 160 SAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVKIDGKK--ILDEEEAEAILAALKGKTFTVTSVE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 244 KKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEgislgkqgtVGLITYMRTDSTRIAETAKAEAATFIEETY 323
Cdd:COG0550 238 KKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYE---------VGLITYMRTDSVRLSEDAVAAAREYIEALY 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 324 GKEFSSHAQRKIKNAQGAQDAHEAVRPTSVLRTPEEikqyLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLEQNGVLF 403
Cdd:COG0550 309 GKEYLPEKPRVYKTSKNAQEAHEAIRPTGVTRTPES----LSGDEFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEF 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 404 IANGSKVKFKGFMQVYVEGRDDGKEDKENILPELAQGDIVQSVDIEPKQHFTQPPARFSEATLIRALEENGVGRPSTYAP 483
Cdd:COG0550 385 RASGKVIKFPGFLKVYGEGKDDEEEEEEKRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAMEELGIGRPSTYAS 464
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1948584369 484 TLDTIQRRYYVKLTQKRFEPTELGEIVNSLICDFFPQIVDIHFTAEMEGDLDKIEEGKEAWIEVVDRFYKPFEKEL 559
Cdd:COG0550 465 IIETLQDRGYVEREGKRLVPTELGFIVIDLLEEHFPDLVDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELV 540
|
|
| topA_bact |
TIGR01051 |
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of ... |
6-613 |
0e+00 |
|
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of bacteria. DNA topoisomerase I transiently cleaves one DNA strand and thus relaxes negatively supercoiled DNA during replication, transcription and recombination events. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273416 [Multi-domain] Cd Length: 610 Bit Score: 860.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 6 LVIVESPAKAKTIEKYLGRNYKVMASVGHIRDLPKSKMGIDVENNYEPHYISIRGKGDVIKSLKSAAKKAQKVYLASDPD 85
Cdd:TIGR01051 1 LVIVESPAKAKTIKKYLGDEYEVEASMGHIRDLPKSRLGVDIEKDFEPEYVVSKGKKKVVKELKTLAKKADEVYLATDPD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 86 REGEAIAWHLAYLLGLDLSEKNRVVFNEITKEAVKAAFKEPRTIDVDLVDAQQARRALDRLVGYSISPILWRKVKKGLSA 165
Cdd:TIGR01051 81 REGEAIAWHLAEVLKPKDPVYKRIVFNEITKKAIRAALKNPREIDMNLVNAQQARRILDRLVGYTLSPLLWKKVAKGLSA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 166 GRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRKKFKANFWGIDGKKKK---LPDAQSVKEVTDRIDGPDFTVQKV 242
Cdd:TIGR01051 161 GRVQSVALRLIVDREREIKRFVPEEYWTIDATFQKGEETFEALLTEVNGKKLKagsDLDEAEATALKEQLKGEELVVEEI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 243 EKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGISLGkQGTVGLITYMRTDSTRIAETAKAEAATFIEET 322
Cdd:TIGR01051 241 EKKPKKSRPPPPFTTSTLQQEASRKLGFSAKKTMMIAQRLYEGVSTG-DGTIGLITYMRTDSTRLSNQAVNEARNLIDKN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 323 YGKEF-SSHAQRKIKNAQGAQDAHEAVRPTSVLRTPEEIKQYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTL--EQN 399
Cdd:TIGR01051 320 YGKEYlGPKPKRYKSKEKNAQEAHEAIRPTSVFRTPEELKDYLKRDEFRLYELIWKRFVASQMADARYDSTSVRLtnEDG 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 400 GVLFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELAQGDIVQSVDIEPKQHFTQPPARFSEATLIRALEENGVGRPS 479
Cdd:TIGR01051 400 EYVFKATGRKLIFDGYYKVYVEGSDDPLEEKDRILPPLKEGDAVKLVEVKPNQHFTQPPARYTEASLVKELEELGIGRPS 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 480 TYAPTLDTIQRRYYVKLTQKRFEPTELGEIVNSLICDFFPQIVDIHFTAEMEGDLDKIEEGKEAWIEVVDRFYKPFEKEL 559
Cdd:TIGR01051 480 TYASIISTIQDRGYVKKENKRLYPTELGFAVTDLLEKHFGDVVDYDFTAKMEKDLDEIAEGKAEWKPVLKNFYTGFSSKV 559
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 1948584369 560 tnaEEKIEKIQIKDEPAGFDCDICGHPMVIKLGKYGKFYACSNFPDCRNTKPIV 613
Cdd:TIGR01051 560 ---KKLRNMRIIVDFKTSQDCPLCGRPMVVKLGKYGPFLACSNFPECKYTKSIV 610
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
4-615 |
0e+00 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 835.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 4 KYLVIVESPAKAKTIEKYLGRNYKVMASVGHIRDLPKS--------------KMGIDVENNYEPHYISIRGKGDVIKSLK 69
Cdd:PRK07561 2 KSLVIVESPAKAKTINKYLGSDYVVKASVGHIRDLPTSassvpakekgalwaRMGVDPDHDFEALYEVLPGKEKVVSELK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 70 SAAKKAQKVYLASDPDREGEAIAWHLAYLLGLDLSEKNRVVFNEITKEAVKAAFKEPRTIDVDLVDAQQARRALDRLVGY 149
Cdd:PRK07561 82 KAAKDADELYLATDPDREGEAIAWHLLEVLGGDDVPVKRVVFNEITKNAIQEAFENPRELDINLVNAQQARRFLDRLVGY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 150 SISPILWRKVKKGLSAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRK-KFKANFWGIDGKK---KKLPDAQSV 225
Cdd:PRK07561 162 MVSPLLWKKIARGLSAGRVQSVAVRLIVEREREIEAFVPEEYWDIHADLTTPRGdAFEARLTHLDGKKfapVDLLNEAQA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 226 KEVTDRIDGPDFTVQKVEKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEgislgkqgtVGLITYMRTDST 305
Cdd:PRK07561 242 EAAVAALEGARYSVASVEDKPTTRKPSAPFTTSTLQQEASRKLGFSVKKTMRIAQRLYE---------AGYITYMRTDST 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 306 RIAETAKAEAATFIEETYGKEFSSHAQRKIKN-AQGAQDAHEAVRPTSVLRTPEEIKqYLDKDQLKLYTLIWSRFVASQM 384
Cdd:PRK07561 313 NLSQEAINAARGYIGDNYGKKYLPEKPRQYSSkAKNAQEAHEAIRPSDVFRTPDQLK-GLEGDAQRLYELIWKRFVASQM 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 385 TPAILDTMKVTLEQNGVLFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELAQGDIVQSVDIEPKQHFTQPPARFSEA 464
Cdd:PRK07561 392 APARYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVEGRDDALDDEDRRLPALKVGDALTLEKLDPTQHFTKPPARYSEA 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 465 TLIRALEENGVGRPSTYAPTLDTIQRRYYVKLTQKRFEPTELGEIVNSLICDFFPQIVDIHFTAEMEGDLDKIEEGKEAW 544
Cdd:PRK07561 472 SLVKELEKLGIGRPSTYASIISTIQDRGYVRLENRRFYPEKMGRIVTDRLEEFFPRLVDYDFTARMEEELDDIANGEADW 551
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1948584369 545 IEVVDRFYKPFEKELTNAEEKIE----KIQIKDEPAgFDCDICGHPMVIKLGKYGKFYACSNF---PDCRNTKPIVKE 615
Cdd:PRK07561 552 KPVLDDFYKDFSQQLEKAEELREeggmRPNQMVITD-RDCPTCGRGMGIRTGKTGVFLGCSGYalkERCKTTRNLTPE 628
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
4-597 |
0e+00 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 668.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 4 KYLVIVESPAKAKTIEKYLGRNYKVMASVGHIRDLPKSKMGIDVENNYEPHYISIRGKGDVIKSLKSAAKKAQKVYLASD 83
Cdd:PRK08780 3 KHLVIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPENGFAMRYDLIDKNEKHVEAIAKAAKSADDLYLATD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 84 PDREGEAIAWHLAYLL---GLdLSEK--NRVVFNEITKEAVKAAFKEPRTIDVDLVDAQQARRALDRLVGYSISPILWRK 158
Cdd:PRK08780 83 PDREGEAISWHLAEILkerGL-LKDKpmQRVVFTEITPRAIKEAMAKPRDIASDLVDAQQARRALDYLVGFNLSPLLWRK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 159 VKKGLSAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRKKFKANFWGIDGKKKKLPD------AQSVKEVTDRI 232
Cdd:PRK08780 162 IQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIEADCAHPSQPFNAKLIKLDGQKFEQFTitdgdtAEAARLRIQQA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 233 DGPDFTVQKVEKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGISLGKQGTVGLITYMRTDSTRIAETAK 312
Cdd:PRK08780 242 AQGTLHVTDVESKERKRNPAPPFTTSTLQQEASRKLGFTTRRTMQVAQKLYEGVDLGDEGSVGLITYMRTDSVNLSQDAL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 313 AEAATFIEETYG-KEFSSHAQRKIKNAQGAQDAHEAVRPTSVLRTPEEIKQYLDKDQLKLYTLIWSRFVASQMTPAILDT 391
Cdd:PRK08780 322 AEIRDVIARDYGtASLPDQPNTYKTKSKNAQEAHEAVRPTSALRTPAQVARFLSDDQRRLYELIWKRAVACQMIPATLNT 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 392 MKVTLE-QNGVLFIANGSKVKFKGFMQVYVEGRDDGK---EDKENILPELAQGDIVQSVDIEPKQHFTQPPARFSEATLI 467
Cdd:PRK08780 402 VSVDLAaGSEHVFRATGSTVVVPGFLAVYEEGKDDKSaedEDEGRKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEASLV 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 468 RALEENGVGRPSTYAPTLDTIQRRYYVKLTQKRFEPTELGEIVNSLICDFFPQIVDIHFTAEMEGDLDKIEEGKEAWIEV 547
Cdd:PRK08780 482 KALEEYGIGRPSTYASIISTLQFRKYVEMEGRRFRPTDVGRAVNKFLTGHFTRYVDYDFTARLEDDLDAVSRGEKEWIPL 561
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 1948584369 548 VDRFYKPFEKELTNAEEKI---EKIQIKDepAGFDcDICGHPMVIKLGKYGKF 597
Cdd:PRK08780 562 MEKFWGPFKELVEEKKDSVdrtEAGQVRE--LGTD-PKSGKPVSVRIGRFGPM 611
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
4-649 |
0e+00 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 663.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 4 KYLVIVESPAKAKTIEKYLGRNYKVMASVGHIRDLPKSKMGIDVENNYEPHYISIRGKGDVIKSLKSAAKKAQKVYLASD 83
Cdd:PRK06319 3 KSLIIVESPAKIKTLQKLLGEGFIFASSLGHIVDLPAKEFGIDIENDFEPDYQILPDKEEVINKICKLAKKCDVVYLSPD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 84 PDREGEAIAWHLAYLLGLDLSEKnRVVFNEITKEAVKAAFKEPRTIDVDLVDAQQARRALDRLVGYSISPILWRKVKK-- 161
Cdd:PRK06319 83 PDREGEAIAWHIANQLPKNTKIQ-RISFNAITKGAVTEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQRrs 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 162 GLSAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFK--KTRKKFKANFWGIDGKK--KKLPDAQSVKEVT-------- 229
Cdd:PRK06319 162 GVSAGRVQSVALKLVVDREKAIEAFVPVEYWNIRVHLKdpKTQKTFWAHLYSVDGKKweKEIPEGKTEDEVLlinskeka 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 230 ----DRIDGPDFTVQKVEKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGISLGKQGTVGLITYMRTDST 305
Cdd:PRK06319 242 dhivELLESATYTVTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSSRTMNIAQTLYEGVDLDSEGATGLITYMRTDSV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 306 RIAETAKAEAATFIEETYGKEFSSHAQRKIKNAQGAQDAHEAVRPTSVLRTPEEIKQYLDKDQLKLYTLIWSRFVASQMT 385
Cdd:PRK06319 322 RTDPEALKQVRKYIEGTFGKEFLPSSPNVYTTKKMAQDAHEAIRPTDITLTPEKLRSKLTEDQYKLYSLIWKRFVASQMI 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 386 PAILDTMKVTLEQN-GVLFIANGSKVKFKGFMQVYVEGRDDGKEDKENI-LPELAQGDIVQSVDIEPKQHFTQPPARFSE 463
Cdd:PRK06319 402 PAIYDTLAIRITTNkGIDLRATGSLLKFKGFLAVYEEKRDDEGDEEENIhLPKLHEQDVLTKEELSAEQAFTKPLPRFTE 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 464 ATLIRALEENGVGRPSTYAPTLDTIQRRYYVKLTQKRFEPTELGEIVNSLICDFFPQIVDIHFTAEMEGDLDKIEEGKEA 543
Cdd:PRK06319 482 ASLVKELEKSGIGRPSTYATIMNKIQSREYTLKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKP 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 544 WIEVVDRFYKPFEKELTNAEE-------------------KIEKIQIKD------------------EPAGFD------- 579
Cdd:PRK06319 562 WKLLLQEFWELFLPVVVTAEKeafiprivteidcpkchkgKLVKIWAKNryfygcseypecdyktseEELTFNkedyaed 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 580 ------CDICGHPMVIKLGKYGKFYACSNFPDCRNTKPIVK--------EIGVTCPV--ChEGQVIERKSKKNRIFYGCS 643
Cdd:PRK06319 642 tpwdspCPLCGGEMKVRHGRFGTFLGCENYPECRGIINIHKkgeegiepEETVPCPAigC-TGHIVKRRSRFNKMFYSCS 720
|
....*.
gi 1948584369 644 RFPDCD 649
Cdd:PRK06319 721 EYPACS 726
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
129-549 |
3.03e-157 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 460.17 E-value: 3.03e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 129 IDVDLVDAQQARRALDRLVGYSISPILWRKVK--KGLSAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRKKFK 206
Cdd:pfam01131 2 IDENLVDAQLARRELDWLIGFNLSRLLTLKLKgnKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGVFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 207 ANFWgidgKKKKLPDAQSVKEVTDRIDGPDFTVQKVEKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEgi 286
Cdd:pfam01131 82 NAKW----KRGRIFDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYE-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 287 slgkqgTVGLITYMRTDSTRI-AETAKAEAATFIEETYGKEFSSHAQ-----RKIKNAQGAQ-DAHEAVRPTSVLRTPEE 359
Cdd:pfam01131 156 ------KHGLITYPRTDSTYLsDDATLKAILEYLTKNYGKYLPYAPRllkktKGKLTVGNAKvTAHEAIRPTGDIPVLPE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 360 ikqyLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLEQNGVLFIANGSKVKFKGFMQVYvegrDDGKEDKENILPELAQ 439
Cdd:pfam01131 230 ----LSDDERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVY----PYEKKEDEEELPELKE 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 440 GDIVQSVDIEPKQHFTQPPARFSEATLIRALEENGVGRPSTYAPTLDTIQRRYYVKLTQKRFEPTELGEIVNSLIcDFFP 519
Cdd:pfam01131 302 GEELKVTQVEVEEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVEAL-EKFP 380
|
410 420 430
....*....|....*....|....*....|
gi 1948584369 520 QIVDIHFTAEMEGDLDKIEEGKEAWIEVVD 549
Cdd:pfam01131 381 DLVDPELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
132-557 |
1.35e-152 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 447.05 E-value: 1.35e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 132 DLVDAQQARRALDRLVGYSISPILWRKV--KKGLSAGRVQSIALKIIIDREKEIRDFIPEEYWSIDgnfkktrkkfkanf 209
Cdd:cd00186 2 NLVNAQLARRILDRLVGFNLSRLLTKKLrrKGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK-------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 210 wgidgkkkklpdaqsvkevtdridgpDFTVQKVEKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGislg 289
Cdd:cd00186 68 --------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEA---- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 290 kqgtvGLITYMRTDSTRIAETAKAEAATFIEETYGKEF----SSHAQRKIKNAQGAQDAHEAVRPTSVLRTPEeIKQYLD 365
Cdd:cd00186 118 -----GLITYPRTDSTRLSEEAILEAREYIQAIYGKEYlypaPLLGRRNPKRGKKEQGAHEAIRPTKVAPTPE-LEANLS 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 366 KDQLKLYTLIWSRFVASQMTPAILDTMKVTLEQNGVLFIANGSKVKFKGFMQVYVEGRDDGKEDkeniLPELAQGDIVQS 445
Cdd:cd00186 192 EDEFKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEEE----PPPLKEGDELKL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 446 VDIEPKQHFTQPPARFSEATLIRALEENGVGRPSTYAPTLDTIQRRYYVKLTQKRFEPTELGEIVNSLICDFFPQIVDIH 525
Cdd:cd00186 268 EEVELEEKETQPPPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFAVIELLEKHFPELVDPE 347
|
410 420 430
....*....|....*....|....*....|..
gi 1948584369 526 FTAEMEGDLDKIEEGKEAWIEVVDRFYKPFEK 557
Cdd:cd00186 348 FTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKK 379
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
1-676 |
5.86e-106 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 337.61 E-value: 5.86e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 1 MAYKYLVIVESPAKAKTIEKYLGRNYKVMASVGHIRDLPKSKMGIDVENNYEPHYISIRGKGDVIKSLKSAAKKAQKVYL 80
Cdd:COG0551 8 ALAAAKEAVKLVKKKKKKKKEGKKKGLAGALGLKKKLVDLLLKEKLKKLVENEKLIAELDIKDLKKLKKDKKKKAKALAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 81 ASDPDREGEAIAWHLAYLLGLDLSEKNRVVFNEITKEAVKAAFKEPRTIDVDLVDAQQARRALDRLVGYSISPILWRKVK 160
Cdd:COG0551 88 ALAAADDDAIEAAAAADEEEALKAAEALEAIRKAVVEEVKSRARKRAARAPADVAAAAAAAALARLLLLAAASRALRLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 161 KGLSAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRKKFKANFWGIDGKKKKLPDAQSVKEVTDRIDGPDFTVQ 240
Cdd:COG0551 168 LLAAGRLRLLSAVAAGLLELEELLKEFEEEEEEEAAEEEEEEEEAKKKKEEDKKKKKKKKKKDKEEETKAIKKKKKAAEA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 241 KVEKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGISLGKQGTVGLITYMRTDSTRIAETAKAEAATFIE 320
Cdd:COG0551 248 VLAAKKAAKEAKAKKELPTTTTDALPEALATTSLTAAAAASALAAALLEEEGELLYTGGYIRYTRTPKSSEADALAALEA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 321 ETYGKEFSSHAQRKIKNAQGAQDAHEAVRPTSVLRTPEEIKQYLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLEQNG 400
Cdd:COG0551 328 LKKIAEEPPDERAKKKKKKAKKKKASEAKETTDHPPIPPTTAAALLELLEDRKLLLELLVRRRFAAAADLAKVEELTKVE 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 401 VLFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELAQGDIVQSVDIEPKQHFTQPPARFSEATLIRALEENGVGRPST 480
Cdd:COG0551 408 EADEEELVEAEGGLLEVLGEEEEDDEDEEEELLLPPLEEGEPLLLEELLLEKQTTTPPPRYTTELLLKKLEEEGGGGRGT 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 481 YAPTLDTI-QRRYYVKLTQKRFEPTELGEIVNSLICDFFPQIVDIHFTAEMEGDLDKIEEGKEAWIEVVDRFYKPFEKEL 559
Cdd:COG0551 488 TATIIILIlKRRYVVLEEKKTTPTELLVEVVLLLLLPFPKLEDTTETAEEEEALLDKEEGKEDKVVEIREEEYPFFKKLL 567
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 560 TNAEEKIEKIQ-IKDEPAGFDCDICGHPMVIKLGKYGKFYACSNFPDCRNTKPIVK--EIGVTCPVCHeGQVIERKSKKN 636
Cdd:COG0551 568 EIAEEEGEEELsEEDEVLGEKCPKCGKPLVIKKGRYGKFLGCSNYPECKYTKPLPKpeVTGVKCPKCG-KKLVLRKSKKG 646
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 1948584369 637 RIFYGCSRFPDCDFTSWDKPVGRNCPKCDQYLVEKKVKGG 676
Cdd:COG0551 647 KVFYGCSNYPKCKFTEWDKPVKEPCPKCGSPLVEKKTKKG 686
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
23-683 |
1.05e-103 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 335.05 E-value: 1.05e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 23 GRNYKVMASVGHIrdlpkskMGIDVENNY------EPHY-ISIRGKGDV-----IKSLKSAAKKAQKVYLASDPDREGEA 90
Cdd:PRK07219 41 GEKWIVIGLSGHI-------VTVDFPEEYgdwrdvDPAElIDADPVKKItkqnyINALKKLAKDADEIIIATDYDREGEL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 91 IAWHlAYLLGLDLSEKN--RVVFNEITKEAVKAAFKEPRTIDVDLVDAQQARRALDRLVGYSISPILW---RKVKKG--L 163
Cdd:PRK07219 114 IGKE-AYHILREVCQVPvkRARFSSLTKKEIRKAFENPDEIDFNLADAGEARQIIDLYWGAALTRFLSlsvRQLGRWdfL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 164 SAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRKKFKANFWGIDgKKKKLPDAQSVKEVTDRIDGPD-FTVQKV 242
Cdd:PRK07219 193 SVGRVQTPTLAFIVDREREIRAFDPEDYWKIEALLDKEAQYFYRDLIGGH-EAEKFWDEEEAEEIYEKLKGAKeATVSSV 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 243 EKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGislgkqgtvGLITYMRTDSTRIAETAKAEAATFiEET 322
Cdd:PRK07219 272 KKRERTISPPAPFNTTEFLREASKIFGISPKRAMEIAEKLYTA---------GYISYPRTDNTVYPDDLDPKELLK-KLS 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 323 YGKEFSSHA-----QRKIKNAQGAQD--AHEAVRPTSVLRTPEeikqyLDKDQLKLYTLIWSRFVASQMTPAILDTMKVT 395
Cdd:PRK07219 342 KKKEYGPYAesileQENIKPTEGKKEttDHPPIHPVDVPKREE-----LSDDEWKVYELIVRRFLATLADPAEWEYLKVE 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 396 LEQNGVLFIANGSKVKFKGFMQVYVEGRDDgkedkENILPELAQGDI--VQSVDIEPKQhfTQPPARFSEATLIRALEEN 473
Cdd:PRK07219 417 LDVNGEIFKASGSRLVEEGWHEVYPYEKFD-----EKELPDLEEGEKlkVNKIEIEAKE--TQPPKRYTQSSLIKEMEKR 489
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 474 GVGRPSTYAPTLDTIQRRYYVkLTQKRFEPTELGEIVNSLICDFFPQIVDIHFTAEMEGDLDKIEEGKEAWIEVVDRFYK 553
Cdd:PRK07219 490 GLGTKATRHDIIEKLYKRGYV-IEGDPPRPTDLGIAVIEALEKYAPEIVSEEMTAQLEADMQAIEDGKKKKEDVTEESRE 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 554 PFEKELTNAEEKIEKI------QIKDEPAGFD----CDICGHPMVIKLGKYGK-FYACSNFPDCRNT------------- 609
Cdd:PRK07219 569 MLKEILSELKEKRKEIgdhlagSLKAENRSLKtigkCPECGGDLIIIRTDKGSrFVGCSGYPDCRNTfplpstgrikvld 648
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 610 -------KPIVKEIGV-------------------------TCPVCHeGQVIERKSKKNRiFYGCSRFPDCDFT------ 651
Cdd:PRK07219 649 evcekcgLPVIKILRGkqtfvvgcpdceaekeeedpdevigPCPKCG-GELAIKQLKYGS-FLGCTNYPKCKYTlplprr 726
|
730 740 750
....*....|....*....|....*....|..
gi 1948584369 652 SWDKPVGRNCPKCDQYLVEKKVKGGKQVVCIN 683
Cdd:PRK07219 727 GKITVTDEKCPECGLPLLRVKGGFGDELGCCN 758
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
243-510 |
7.33e-97 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 299.16 E-value: 7.33e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 243 EKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGislgkqgtvGLITYMRTDSTRIAETAKAEAATFIEET 322
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEK---------GLITYPRTDSTRLSEEAVLEARNYIQKL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 323 YGKEFSSHAQ-----RKIKNAQGAQDAHEAVRPTSVLRTPEEIKQyLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLE 397
Cdd:smart00437 72 YGKEYLDLAVvllkpRKPRKGKKAQGAHEAIRPTKPIFTPELEKE-LSEDEFKLYELIWRRFLASQMPDAKYEETKVTIK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 398 QNGVLFIANGSKVKFKGFMQVYVEGrddgKEDKENILPELAQGDIVQSVDIEPKQHFTQPPARFSEATLIRALEENGVGR 477
Cdd:smart00437 151 IGGEKFKAKGKTLLFDGWLKVYPEE----KKEEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGR 226
|
250 260 270
....*....|....*....|....*....|...
gi 1948584369 478 PSTYAPTLDTIQRRYYVKLTQKRFEPTELGEIV 510
Cdd:smart00437 227 PSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| TopG2 |
COG1110 |
Reverse gyrase [Replication, recombination and repair]; |
6-552 |
6.49e-96 |
|
Reverse gyrase [Replication, recombination and repair];
Pssm-ID: 440727 [Multi-domain] Cd Length: 1219 Bit Score: 321.54 E-value: 6.49e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 6 LVIVESPAKAKTIEKYLGR-----------------NY--KVMASVGHIRDL-----PKSKMGIDVENN-YEPHYISI-- 58
Cdd:COG1110 632 LVIVESPNKARTIASFFGKpsrrrigglrvyevsigDYllLITASGGHVFDLvteayARGFYGVLVENGrFIPVYDTIkr 711
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 59 -----------------------RGKGDVIKSLKSAAKKAQKVYLASDPDREGEAIAWHLAYLLGLDLSEKNRVVFNEIT 115
Cdd:COG1110 712 cldcgeqftdevevcprcgspniVDSLEIVEALRELATEVDEVLIGTDPDTEGEKIGWDVYNLLRPYAKNIKRIEFHEVT 791
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 116 KEAVKAAFKEPRTIDVDLVDAQQARRALDRLVGYSISPILWRKVKKG-LSAGRVQSIALKIIIDREKEirdfipeeywsi 194
Cdd:COG1110 792 RKAILEALKNPREIDENLVEAQIVRRIEDRWIGFTLSQKLWKVFGNRnLSAGRVQTPVLGWIIERYEE------------ 859
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 195 dgnFKKTRKKFKANFWGIDGKKKKLPDAQSVKEVTDRIDGPD-FTVQKVEKKERKRNPANPFTTSSLQQEAARKLNFRTR 273
Cdd:COG1110 860 ---SRKSKKYLIILTLENGRLELSIEDLKEAEEVRKALEKEVkVKVKKVEEEEEELNPLPPYTTDTLLRDASRRLGLSAE 936
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 274 KTMMVAQQLYEgislgkqgtVGLITYMRTDSTRIAETAKAEAATFIEETYGKEFssHAQRKiknaQGAQDAHEAVRPT-- 351
Cdd:COG1110 937 ETMRLAQDLFE---------SGLITYHRTDSTRVSDAGIAVAKEYISERFGEEY--FKPRR----WGEGGAHEAIRPTrp 1001
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 352 ------------SVLRTPEEikqyLDKDQLKLYTLIWSRFVASQMTPAILDTMK--VTLEQNG----VLFIangSKVKFK 413
Cdd:COG1110 1002 ldaedlrrlieeGVIELPIP----LTRRHLRLYDLIFRRFMASQMRPAKVEKVKlrVSLELPGgeieEERI---VEIIED 1074
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 414 GFMQVYVEGRddgkedkenILPELAQGDI-VQSVDIEpKQHFTQPparFSEATLIRALEENGVGRPSTYAPTLDTIQRRY 492
Cdd:COG1110 1075 GFLLIYPPIK---------VEPELKEGEYkVTEVKIR-KVPKVPL---YTQGDLVREMKERGIGRPSTYAKIVETLLRRG 1141
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1948584369 493 YVKLT--QKRFEPTELGEIVNSLICDFFPQIVDIHFTAEMEGDLDKIEEGKEAWIEVVDRFY 552
Cdd:COG1110 1142 YVVESkkGKKLVPTKLGIEVYNYLSENFPDLVSEERTRELEEKMDEIEEGEADYQDVLEELY 1203
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
23-606 |
4.88e-92 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 298.66 E-value: 4.88e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 23 GRNYKVMASVGHIRDL-PKSKMG---IDVEnnYEPHYISIRGKG---DVIKSLKSAAKKAQKVYLASDPDREGEAIAWH- 94
Cdd:TIGR01057 37 GKKIIVASAVGHLFGLhPKSRGGypvFDIE--WVPIFEFDKGKGyvsKYIKALSKLAKGADEYINACDYDIEGEVIGFKa 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 95 LAYLLGLDLSEknRVVFNEITKEAVKAAFKEPRTIDVDLVDAQQARRALDRLVGYSISPILWRKVKKG------LSAGRV 168
Cdd:TIGR01057 115 LKYFCGVERAK--RMKFSTLTKQDIRRAYANPEEIDYGMVDAGMARHILDWYWGINLSRALMEAIRAAagrwviLSAGRV 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 169 QSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRKKFKANFWGidGKKKKLPDAQSVKEVTDriDGPDFTVQKVEKKERK 248
Cdd:TIGR01057 193 QGPTLAFLVEREREINLFVPKPYWVIKATLEKGGGVFDARPEK--WKIWSEEEAKSIKEELK--KSPWAAVEEVRSERSI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 249 RNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGislgkqgtvGLITYMRTDSTRIAETAKAEAAtFIEETYGKEFS 328
Cdd:TIGR01057 269 LKPPPPFDLGTLQREAYRIFGFSPKKTQSIAQELYEE---------ALISYPRTSSQKLPPSINYRAI-LDNLAKGPLYR 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 329 SHAQR-----KIKNAQGAQD--AHEAVRPTSVLRTPEeikqyLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLEQNGV 401
Cdd:TIGR01057 339 EAAERlletgVLKPVEGKKEdpAHPAIHPTGEIPSQE-----LSKDEKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQE 413
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 402 LFIANGSKVKFKGFMQVYVEGRDDGKEdkeniLPELAQGDIVQSVDIEPKQHFTQPPARFSEATLIRALEENGVGRPSTY 481
Cdd:TIGR01057 414 KFRLSGLRVVKLGWLEYYHYSKFEEKE-----LPPLDRGDKIKVVRVDVRVKETQPPARYDKASLIREMESRGLGTKATR 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 482 APTLDTIQRRYYVKlTQKRFEPTELGEIVNSLICDFFPQIVDIHFTAEMEGDLDKIEEGKEAWIEVVDRFYKPFEKELTN 561
Cdd:TIGR01057 489 ARIIETLYKRGYIE-GKKSIKVTPLGEAVIETLQRYCPEIISEELTRRFESKLEDIMSGRITKDEVIDEAKKRLRKILEE 567
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 1948584369 562 AEEKIEKIQIK------DEPAGFDCDICGHPMVIKLGKYGKFYACSNFPDC 606
Cdd:TIGR01057 568 FKKRLDDIGIElgkslgSVEVVGKCPKCGGKLVSKYAKKGRFVGCSNYPEC 618
|
|
| rgy |
TIGR01054 |
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial ... |
6-553 |
4.29e-89 |
|
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial thermophiles. This enzyme, a fusion of a type I topoisomerase domain and a helicase domain, introduces positive supercoiling to increase the melting temperature of DNA double strands. Generally, these gyrases are encoded as a single polypeptide. An exception was found in Methanopyrus kandleri, where enzyme is split within the topoisomerase domain, yielding a heterodimer of gene products designated RgyB and RgyA. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273418 [Multi-domain] Cd Length: 1171 Bit Score: 302.13 E-value: 4.29e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 6 LVIVESPAKAKTIEKYLGR-------------------NYKVMASVGHIRDL--PKSKMGIDVEN-NYEPHYISI----- 58
Cdd:TIGR01054 604 LLVVESPNKARTIARFFGKpsvrkiggsvvyevpvgdlILMITASGGHVFDLvtDKGFHGVLVENgRYVPVYTSIkrcrd 683
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 59 --------------------RGKGDVIKSLKSAAKKAQKVYLASDPDREGEAIAWHLAYLLGLDLSEKNRVVFNEITKEA 118
Cdd:TIGR01054 684 cgyqftedrescpkcgseniEDSKSIIEILRELAHEVDEVFIGTDPDTEGEKIGWDLALLLSPYNPNVKRAEFHEVTRRA 763
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 119 VKAAFKEPRTIDVDLVDAQQARRALDRLVGYSISPILWRKV-KKGLSAGRVQSIALKIIIDREKEIRDfipeeywsidgn 197
Cdd:TIGR01054 764 ILEALESPRSVDENLVKAQVVRRIEDRWIGFTLSQKLWEAFnKRWLSAGRVQTPVLGWIIDRYRESRE------------ 831
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 198 fkktRKKFKANFwgidgkkKKLPDAQSVKEVTDRIDGPDFT-------VQKVEKKERKRNPANPFTTSSLQQEAARKLNF 270
Cdd:TIGR01054 832 ----KRGYLLIF-------ALESDFRLGLEHDNRLEAKEFEkdltwldVEDIAEREEERNPLPPYTTDTMLEDANRKLGL 900
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 271 RTRKTMMVAQQLYEgislgkqgtVGLITYMRTDSTRIAETAKAEAATFIEETYGKEFsshaqrKIKNAQGAQDAHEAVRP 350
Cdd:TIGR01054 901 SVKETMQIAQELFE---------NGLITYHRTDSTRVSDVGMRVAKEYLASRLGGEY------FYPREWGEGGAHECIRP 965
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 351 TSVLrTPEEIKQYLDKDQ----------LKLYTLIWSRFVASQMTPAILDTMKVTLEQNGV-LFIANGSKVKFKGFMQVY 419
Cdd:TIGR01054 966 TRPL-DVDDLQRLILEGVielegltrehLRLYDLIFRRFMASQMRPAKVDTKEITLKADGKeAEEEGIVEIVERGFELVY 1044
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 420 VEGRddgkedkeniLPELAQGDIVQSVDIEPKQHFTQPParFSEATLIRALEENGVGRPSTYAPTLDTIQRRYYVKLTQK 499
Cdd:TIGR01054 1045 PLWR----------KNELEKGSTFIVKDKELRSVPKVYP--YTQGEIVQEMKERGIGRPSTYATIVEKLLRRGYVVESKG 1112
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 1948584369 500 RFEPTELGEIVNSLICDFFPQIVDIHFTAEMEGDLDKIEEGKEAWIEVVDRFYK 553
Cdd:TIGR01054 1113 FLIPTKLGIEVYNYLTNRYPKLVSEDRTRELEEAMDKIERGELDYLEVLESVYR 1166
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
4-617 |
2.57e-88 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 290.36 E-value: 2.57e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 4 KYLVIVESPAKAKTI-----EKYL---------------GRNYKVMASVGHIRDLPKSKMGIDV-ENNYEPHYISIRGKG 62
Cdd:PRK05776 2 YILVIAEKPKAARKIaealsEKPIrcriygvpywivkrdGKKIVVAPAAGHLFGLHTKSKGFPVfDYEWKPLYEIDKGSK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 63 ---DVIKSLKSAAKKAQKVYLASDPDREGEAIAWHLAYLLGlDLSEKNRVVFNEITKEAVKAAFKEPRTIDVDLVDAQQA 139
Cdd:PRK05776 82 ytkKYYELLSSLSKYADEFINACDYDIEGSVIGYLIIKYLG-DPKKAKRMKFSALTKSDIRRAFRNLETLDYEMINAGIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 140 RRALDRLVGYSISPILWRKVKKG------LSAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRKKFKANFwgid 213
Cdd:PRK05776 161 RHELDWLWGINVSRALMSSVRDAsgkrviLSAGRVQSPTLKYVVEREIERNLFVPLPYFSVSIIIEKNGYEFTLKY---- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 214 gKKKKLPDAQSVKEVTDRI-DGPDFTVQKVEKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGislgkqg 292
Cdd:PRK05776 237 -ENKKFETKEEAKEILEEIkKTGYLKVTKVEVKIEILEPPPPFNLGDLQVEAARIYGFSPYKTQSIAEDLYLD------- 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 293 tvGLITYMRTDSTRI---------------AETAKAEAATFIEETYGKefsshaqrkIKNAQGAQD--AHEAVRPTSVlr 355
Cdd:PRK05776 309 --GLISYPRTNSQKLpptlnirnilkglsrSPQYRPLVNLLLKETKGV---------LKPVQGPKDdpAHPAIYPTGE-- 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 356 TPEEikqyLDKDQLKLYTLIWSRFVASQMTPAILDTMKVTLEQNGVL--FIANGSKVKFKGFMQVYVEGRDDGKEdkeni 433
Cdd:PRK05776 376 PPKN----LSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPGFPlvFSASGQRIEERGWLKYYPFHKFDEEE----- 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 434 LPELAQGDIVQSVDIEPKQHFTQPPARFSEATLIRALEENGVGRPSTYAPTLDTIQRRYYVKLTQKRFEPTELGEIVNSL 513
Cdd:PRK05776 447 LPLLKKGERVKIVDVKVRKSYTKPPSRYSKASLLKWMESVGIGTEATRARIIETLFKRGYLTSNGKYIEVTPLGFGVAEV 526
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 514 ICDFFPQIVDIHFTAEMEGDLDKIEEGKEAWIEVVDR-------FYKPFEKELTNAEEKIEKIQIKDEPAGfDCDICGHP 586
Cdd:PRK05776 527 LEKYFPDIVSVELTRDFEEKLEMIRTGKATREEVIEEaketlnkLLEEFKKNKDEIGEELAKALGLIKPVG-KCKICGRE 605
|
650 660 670
....*....|....*....|....*....|....*..
gi 1948584369 587 MVIK-LGKY-----GKFYACSNFPDCRNTKPIvKEIG 617
Cdd:PRK05776 606 AYKDgLCKYhyeakKRLVKAYEEWKERTGYDH-KEYL 641
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
64-655 |
1.24e-78 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 265.85 E-value: 1.24e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 64 VIKSLKSAAKKAQKVYLASDPDREGEAI---AWHLAYLLGLDLsEKNRVVFNEITKEAVKAAFKEPRTIDVDLVDAQQAR 140
Cdd:PRK07220 87 IVTALKKLGKEADRVTIATDYDREGELIgveALNIIKKVNPDI-KFDRVRYSAITKKEIERAFSNPVEVDFNLADAGHSR 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 141 RALDRLVGYS----ISPILWRKVKKGLSAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRKKFKANFwgidgKK 216
Cdd:PRK07220 166 QVIDLVWGAAltryISLAAGRLGKMFLSVGRVQSPTLALIVDREKEREAFVPTPYWEIYATLENNGETFVAQH-----ST 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 217 KKLPDAQSVKEVTDRIdGPDFTVQKVEKKERKRNPANPFTTSSLQQeAARKLNFRTRKTMMVAQQLYegislgkqgTVGL 296
Cdd:PRK07220 241 RRFWEKEEADRVFEKL-GKTAEVTEVEKGTKTDKPPTPFNTTEFIS-AANSIGFSAANAMRIAESLY---------TNGY 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 297 ITYMRTDSTriAETAKAEAATFIEETYGKEFSSHAQR-----KIKNAQGAQDA--HEAVRPTSVLRTPEeikqyLDKDQL 369
Cdd:PRK07220 310 ISYPRTDNT--VYPESLDLREQIEIFAEGPFGEYAQKllekgELVPTRGKKETtdHPPIYPASLAKKSE-----LKEDEW 382
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 370 KLYTLIWSRFVASQMTPAILDTMKVTLEQNGVLFIANGSKVKFKGFMQVYVEGRddgkeDKENILPELAQGDIVQSVDIE 449
Cdd:PRK07220 383 KVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPYNA-----PEDRLLPELSEGEELKVKKKE 457
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 450 PKQHFTQPPARFSEATLIRALEENGVGRPSTYAPTLDTIQRRYYVKltQKRFEPTELGEIVNSLICDFFPQIVDIHFTAE 529
Cdd:PRK07220 458 MLDKETQPPGRYGQGRLIKLMEDLGLGTKATRHEIISKLYSRAYIH--GNPIQPTNTAFAVVDALEKYAPTITKPDMTSR 535
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 530 MEGDLDKIEEGKEAWIEVVDRFYKPFE---KELTNAEEKIEKIQI----KDEPAGfDCDICGHPMVIKLGKYGK-FYACS 601
Cdd:PRK07220 536 LEEDMDKIAEGKIKEDAVLEESREMLEqvfDELDKNREKIRESLReglrEDKIIG-KCPLCGSDLMVRRSKRGSrFIGCE 614
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1948584369 602 NFPDCRNTKPIVK--EIGVTCPVC-----HEGQVIERKSKKNRIfyGCsrfPDCDFTSWDK 655
Cdd:PRK07220 615 GYPECTFSLPLPKsgQIIVTDKVCeahglNHIRIINGGKRPWDL--GC---PQCNFIEWQK 670
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
64-624 |
6.68e-70 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 240.45 E-value: 6.68e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 64 VIKSLksaAKKAQKVYLASDPDREGEAIAWHLAYLLGLDlseKN--RVVFNEITKEAVKAAFKEPR----TIDvdLVDAQ 137
Cdd:PRK07726 85 VVKKL---LKQATEIVIATDADREGELIAREILDYCGVR---KPikRLWISSLTDKAIKRAFANLKpgkeTIP--LYYSA 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 138 QAR-RAlDRLVGYSISPILWRKVKKG-----LSAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKkTRKKFKANfW- 210
Cdd:PRK07726 157 LARsRA-DWLVGINMTRAYTLLGRKAgyngvLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLT-PGERFTAK-Wq 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 211 ------GIDGKKKKLPDAQSVKEvtdRIDGPDFTVQKVEKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYE 284
Cdd:PRK07726 234 psepyqDEEGRLLDRPLAEQVVA---RIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQSLYE 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 285 gislgkqgTVGLITYMRTDS------------TRIAETAKAeaatfieETYGKEFSSHAQRKIKNA---QGAQDAHEAVR 349
Cdd:PRK07726 311 --------THKLITYPRTDSrylpedmvatlpEVLNAISKV-------DPYLLLAPPVLDPSIRSRawnDKKVTAHHAII 375
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 350 PTsvlrtpeEIKQYLDK---DQLKLYTLIWSRFVASQMTPAILDTMKVTLEQNGVLFIANGSKVKFKGFMQVYveGRDDG 426
Cdd:PRK07726 376 PT-------EQPPNLSKlseDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALL--GKKEE 446
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 427 KEDKENILPELAQGDIVQSVDIEPKQHFTQPPARFSEATLIRA----------------LEEN-GVGRPSTYAPTLDTIQ 489
Cdd:PRK07726 447 DEEKEQPLPVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLLSAmeniarfvqdkelkktLKETdGLGTEATRAGIIEKLF 526
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 490 RRYYVKLTQKRFEPTELGEivnSLIcDFFPQ-IVDIHFTAEMEGDLDKIEEGKEAwievvdrfYKPFEKELTN-AEEKIE 567
Cdd:PRK07726 527 KRGYLEKKGKYIHATDKGK---QLI-DALPEeLTSPDMTAKWEQALDQISEGQLS--------YQDFMQPLKQwLKQLVE 594
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1948584369 568 KIQIKDEPAGFD------CDICGHPMVIKLGKYGKFYACSNFPDCRnTKPIVKEIGVTCPVCH 624
Cdd:PRK07726 595 QAKQSSEKYKFDnltgpkCPDCGKPMLKVKGKNGKMLVCQDRECGK-RKNVSKKTNARCPNCK 656
|
|
| COG1754 |
COG1754 |
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]; |
1-615 |
1.08e-65 |
|
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
Pssm-ID: 441360 [Multi-domain] Cd Length: 892 Bit Score: 233.17 E-value: 1.08e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 1 MAYKYLVIVESPAKAKTIEKYLGRNYKVMASVGHIRDLPKSKMGIDVENNYEPHYISIRGKGDVIKSLKSAAKKAQKVYL 80
Cdd:COG1754 2 SAAVLVVVVVVVVKVPAAKKVLPKYAKKKKGVKAVLKKADVAKADDKVVDDDDKKDDVDDDKKKKKKLLKAAAKKKKALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 81 ASDPDREGEAIAWHLAYLLGLDLSEKNRVVFNEITKEAVKAAFKEPRTIDVDLVDAQQARRALDRLVGYSISPILWRKVK 160
Cdd:COG1754 82 LALAADDEDEELLAADDELEEEKVIKLLLLELAVERVARAAAVRAAAAEAARLAALLRRRLVLRRLVRRLLVRLLLLRLV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 161 KGLSAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRKKFKANFWGID------------GKKKKLPDAQSVKEV 228
Cdd:COG1754 162 LLLLRLLVARRAARRRRRRRRRRARRRELERRRERARAAEAEEAAAAAAAAADagraaaardgkgGGKLAAGGAAAAAAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 229 TDRIDGPDFTVQKVEKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEGISLGKQGTVGLITYMRTDSTRIA 308
Cdd:COG1754 242 AAAAAAAAAALAEAAAAAAVREPPTPTTTTTAQAATTTTTRAAAARTTRSAQQAARRTRLGGEGTYTTTTTTTTTTSAAA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 309 ETAKAEAATFIEETYGKEFSSHAQRKIKNAQGAQDAHEAVRPTSVLRTPEEIKQYLDKDQLKLYTLIWSRFVASQMTPAI 388
Cdd:COG1754 322 AAAAAAAAALAAAAAAAYAPPPPYYYKKKAAAAAAAAAAAAAAAARRPPAARAALLSDDRLLLELLLLRRTAAAAAAAAA 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 389 LDTMKVTLEQNG----VLFIANGSKVKFKGFMQVYVEGRDDGKEDKENILPELAQGDIVQSVDIEPKQHFTQPPARFSEA 464
Cdd:COG1754 402 ATATTTAAAAAAgagaVGTAAAGAVFFFGGFLLFAEEEDDDEEDDDDDDLPALEEGLPLLKEGVLADQHFTQPPPRYTEA 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 465 TLIRALEENGVGRPSTYAPTLDTIQRRYYVKLTQKRFEPTELGEIVNSLICDFFPQIVDIHFTAEMEGDLDKIEEGKEAW 544
Cdd:COG1754 482 PLVKRMEELGIGRPSTYASILSTLADRIYVRLDKRRLIPEDKGRLVTAFLFSFFRRYVEYDFTADLEEFLDDVSDGELDW 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 545 IEVVDRFYKPF--EKELTNAEEKIEKIQIKDEPAGFD------CDICGHPMVIKLGKYGKFYACSN-------FPDCRNT 609
Cdd:COG1754 562 KAVLRRFWRDFsaAYDETGDLRISEVLDALEDLGEIDpreinsCPLGTGGLSLRVGRYGPFIECSNyeprrasIPECLAP 641
|
....*.
gi 1948584369 610 KPIVKE 615
Cdd:COG1754 642 DELTPE 647
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
4-126 |
3.24e-62 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 203.18 E-value: 3.24e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 4 KYLVIVESPAKAKTIEKYLGRNYKVMASVGHIRDLPKSKMGIDVENN-YEPHYISIRGKGDVIKSLKSAAKKAQKVYLAS 82
Cdd:cd03363 1 KKLVIVESPAKAKTIKKYLGKEYEVLASVGHIRDLPKKGLGVDGEDDgFEPKYVVIPGKKKVVKELKKLAKKADEIYLAT 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1948584369 83 DPDREGEAIAWHLAYLLGLDlSEKNRVVFNEITKEAVKAAFKEP 126
Cdd:cd03363 81 DPDREGEAIAWHLAEVLKLK-KNVKRVVFNEITKEAIKEALKNP 123
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
5-607 |
7.07e-60 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 217.02 E-value: 7.07e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 5 YLVIVESPAKAKTIEKYLGRNYKVMA----SVGHIRDLPKSKMGID---VENNYEPHYISIRGKGDVIKSLKSA------ 71
Cdd:PRK14973 2 HLIIAEKNIAANRIAQILAGKTKVQVkkdgGVSTYSFDDTVVVGLRghvVEVDFEPGYTNWRSEEHTPRSLIDAdtikkp 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 72 ------------AKKAQKVYLASDPDREGEAIAWHlAYLLGLDLSEK---NRVVFNEITKEAVKAAFKEPRTIDVDLVDA 136
Cdd:PRK14973 82 tekkivgliqklAKKADRVTIATDFDTEGELIGKE-AYELVRAVNPKvpiDRARFSAITKEEIVTAFAEPTDLDFALAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 137 QQARRALDRLVGYSISPILWRKVKKG----LSAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRKKFKANFwgi 212
Cdd:PRK14973 161 GEARQIIDLIWGASLTRFISLAAHRGgdniLSVGRVQSPTLAMIVDREKEIEAFVPEKYWMLSLATEKDGEGIEARH--- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 213 dgKKKKLPDAQSVKEVTDRIDGPDFTVQKVEKKERKRNPAnPFTTSSLQQEAARkLNFRTRKTMMVAQQLYEGislgkqg 292
Cdd:PRK14973 238 --THGRFTDSAAAEAAYDATKEPLVVTEVKEGHKVDRAPT-PFDTTTFIVAASR-LGFSAANAMRIAEDLYMN------- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 293 tvGLITYMRTDSTRIAETAKAEAATFIEEtyGKEFSSHA-----QRKIKNAQGAQDA--HEAVRPTSVlRTPEEIKQyld 365
Cdd:PRK14973 307 --GYISYPRTDNTIYPKSLDLNGVLATLA--KGAFSKDVawvkdNRRPVPTRGKKSStdHPPIHPTGV-ATREELGD--- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 366 kDQLKLYTLIWSRFVASQMTPAILDTMKVTLEQNGVLFIANGSKVKFKGFMQVYvegrdDGKEDKENILPELAQGDI--V 443
Cdd:PRK14973 379 -DRWKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVY-----PYSEAKENILPAFALGEKlpI 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 444 QSVDIEPKQhfTQPPARFSEATLIRALEENGVGRPSTYAPTLDTIQRRYYVKLTQKRfePTELGEIVNSLICDFFPQIVD 523
Cdd:PRK14973 453 LAVNLEEKE--TQPPARYSQSRLIQRMEELGLGTKSTRHEVIGKLVSRKYIEGNPLR--PTLVGRAVTESLEEHAGTITE 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 524 IHFTAEMEGDLDKIEEGKEAWIEVVDRFYKPFEKELTNAEEKIEKI------QIKDEPAGFDCDICGHPMVIKLGKYGKF 597
Cdd:PRK14973 529 PDMTQTLEEHMQQIKERKRTRDDVVTESRKMLHRAFDELEANEAVIgrdimeRTAEELTIGPCPVCGKDLRIKHIGSSQF 608
|
650
....*....|
gi 1948584369 598 YACSNFPDCR 607
Cdd:PRK14973 609 IGCSGYPDCT 618
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
63-607 |
3.34e-48 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 180.42 E-value: 3.34e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 63 DVIKSLKSAaKKAQKVYLASDPDREGEAIA-WHLAYLLGLDLSEKNRVVFNEITKEAVKAAFKE--PRTIDVDLVDAQQA 139
Cdd:TIGR01056 85 NVIKRILKE-NKVDEVVIATDPDREGELIArEILDYLKVTDKVTIKRLWISSLVDSSIRKAFKNlrPKSETEGLYKSGVA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 140 RRALDRLVGYSIS---PILWRKVKKG--LSAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRKKFKANFWGIDG 214
Cdd:TIGR01056 164 RARADWLVGINLTrafTKLGREAGNDgvLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVSATINKDEQEFTTEWQPYKD 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 215 KKKKLPDAQSVKEVTDRIDGPDFTVQKVEKKERKRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEgislgkqgTV 294
Cdd:TIGR01056 244 EEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRTLDIAQKLYE--------TH 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 295 GLITYMRTDSTRIAETAKAEAATFIEETYGKEFSSHAQRKIKNAQGAQ-------DAHEAVRPTSvlrtPEEIKQYLDKD 367
Cdd:TIGR01056 316 KLITYPRTDSRYLPEDEKEMLLEVLDALKVITPALLPIKKRDELTNNRlwndkkiEDHHAIIPTG----NDFNLSDLSEE 391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 368 QLKLYTLIWSRFVASQMTPAILDTMKVTLEQNGVLFIANGSKVKFKGFMQVYVEGRDDgKEDKENILPELAQGDIVQSVD 447
Cdd:TIGR01056 392 ERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEED-EETEDTTLPAFQKGDELDVET 470
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 448 IEPKQHFTQPPARFSEATLIRAL-----------------EENGVGRPSTYAPTLDTIQRRYYVKLTQKRFEPTELGEiv 510
Cdd:TIGR01056 471 LELLEKQTKPPARYTEGTLLSAMtnpaafvqdkglkktlkETKGLGTEATRADIIENLFKRGFIQKKKNKIYITKNGK-- 548
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 511 nsLICDFFPQIV-DIHFTAEMEGDLDKIEEGK---EAWIEVVDRFYKPFEKELTNAEEKIEKIQIKDEPagfdcdiCGHP 586
Cdd:TIGR01056 549 --LLCLLLPELLtKPDLTAQWEQYLNGISAGEkddDDFINTINEMIKQTINEEKKNPETIQKVAKEPVS-------CGGI 619
|
570 580
....*....|....*....|.
gi 1948584369 587 MVIKLGKYGKFYACSNFPDCR 607
Cdd:TIGR01056 620 AKCPAKDNGRLIDCKKFPECT 640
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
2-537 |
4.91e-43 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 166.65 E-value: 4.91e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 2 AYKYLVIVESPAKAKTIEKYLGrNYKV-----------------------MASVGHIRDLPkskmgidvENNYEPHYI-- 56
Cdd:PTZ00407 8 ALEKLVIVESPNKVIKVEGLLS-DPKVipdwsfkqshlrrigtgaekavaMATTGHFMALK--------EITWSPQASsp 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 57 -SIRGKGD---------------------------VIKSLKSAAKKAQKVYLASDPDREGEAIAWHLAYLLGLDLSEKN- 107
Cdd:PTZ00407 79 aSVVGAGDepfpsngtlaeytlewellpgrriqetLERYIEEKADNVTEIILATDPDREGELIAVHALQTIKRLYPKLKv 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 108 ---RVVFNEITKEAVKAAFKE--PRTIDVDLVDAQQARRALDRLVGYSISPILWRKVKKGLSAGRVQSIALKIIIDREKE 182
Cdd:PTZ00407 159 pfsRAYMHSITEDGIRKAMRErhVEACDYDLANAAETRHAMDRIFGFLGSSVVRAANSQMRSIGRVQTPALILINEREDK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 183 IRDFIpeeywsiDGNFKKTRKKFKANFWGIDGKKKklpdAQSVKEVTDRIDGPDFTVQKVEKKER--------------- 247
Cdd:PTZ00407 239 IKAFL-------ESNKSTFEVQAMCQFPSPHGTTF----SQVVTITPDRKGGASHWATEAEARRCleqwklnnctgfsvp 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 248 --------KRNPANPFTTSSLQQEAARKLNFRTRKTMMVAQQLYEgislgkqgtVGLITYMRTDSTRIAETAKAEAATFI 319
Cdd:PTZ00407 308 lepkpqpsVVPPPQPFTMATAIAKANRQLKYSSEMVSGCLQDLFQ---------LGHITYPRTDSTRIDESALPDIYAAV 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 320 EETYGKEF-----------------------SSHAQRKIKNAQGA--QDAHEAVRPTSVLRTPEEIKqyLDKDQLKLYTL 374
Cdd:PTZ00407 379 KKEFGKEFlyrledrtvsaqegkgskktgkkRSTKQKKGADTPVGnvEDAHEAIRPTNIDTTGESLS--LSPPTRAVYDL 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 375 IWSRFVASQMTPAILDTMKVTleqngVLFIA-NGSKVKF--------------------KGFMQVYVEGRDDGKEDKEN- 432
Cdd:PTZ00407 457 VRRNTLAVFMIPMKTEKIVAT-----VKFTSgSGEKLEFelqgkrvvepgwtrafhkgdKGTTGPAEETDEDITAVEEGa 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 433 -ILPELAQGDIVQSVDIEP------KQHFTQ------------PPARFSEATLIRALEENGVGRPSTYAPTLDTIQRRYY 493
Cdd:PTZ00407 532 pVVPSLSQEEFKAIMNLRSqlgsgvQKGFFElrspqvrenrpvPPLPHSEGTLIEELKNNGVGRPSTYPMIVKTLLARGY 611
|
650 660 670 680
....*....|....*....|....*....|....*....|....*
gi 1948584369 494 VKLTQK-RFEPTELGEIVNSLICDFFPQIVDIHFTAEMEGDLDKI 537
Cdd:PTZ00407 612 IAVNPKgRCETTPVGRMLVETAKSTFPSIVDIGFTAAFEKKLDRI 656
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
4-126 |
4.73e-40 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 143.52 E-value: 4.73e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 4 KYLVIVESPAKAKTIEKYLGR------------NYKVMASVGHIRDLPKSKMGIDVENN-------YEPHYISIRGKGDV 64
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKILGKgskkkgfygeggGYVVTASVGHLLELPFPEEYVDWDKDwplelfpFEPKYVVIPDKKKQ 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1948584369 65 IKSLKSAAKKAQKVYLASDPDREGEAIAWHLAYLLGLDLSEKNRVVFNEITKEAVKAAFKEP 126
Cdd:cd01028 81 LKALKKLAKKADEIVLATDPDREGELIAWEILEVLKCDNKPVKRAWFSEITPKAIREAFKNL 142
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
108-192 |
1.96e-39 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 140.03 E-value: 1.96e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 108 RVVFNEITKEAVKAAFKEPRTIDVDLVDAQQARRALDRLVGYSISPILWRKVKK-GLSAGRVQSIALKIIIDREKEIRDF 186
Cdd:smart00436 3 RIEFSEITKKAIREALKNPREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRNgVLSAGRVQTPTLGLIVEREREIKNF 82
|
....*.
gi 1948584369 187 IPEEYW 192
Cdd:smart00436 83 VPKPYW 88
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
4-673 |
2.89e-35 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 143.27 E-value: 2.89e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 4 KYLVIVESPAKAKTIEKYLGR-----------NYKVMASVGHIrdlpkskMGIDVENNYEPhyisIRGKGD-----VIK- 66
Cdd:PRK08173 3 KALIIAEKPSVANDIARALGGftkhdeyfesdEYVLSSAVGHL-------LEIAAPEEYEV----KRGKWSfahlpVIPp 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 67 --SLKSAAKKAQKVYL---------------ASDPDREGEAIAWHLAYLLGLDLSEKnRVVFNEITKEAVKAAFKEPRTi 129
Cdd:PRK08173 72 hfDLNPIAKTESRLKVltklikrkdvtrlinACDAGREGELIFRLIAQHAKAKKPVK-RLWLQSMTPQAIRDGFANLRS- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 130 DVD---LVDAQQARRALDRLVGYSISpilwrkvkKGLSA-------------GRVQSIALKIIIDREKEIRDFIPEEYWS 193
Cdd:PRK08173 150 DEDmqpLADAARCRSEADWLVGINGT--------RAMTAfnskgggfflttvGRVQTPTLSIVVEREEKIRRFVPRDYWE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 194 IDGNF---------KKTRKKFKANFWGIDGKKKKLPDAQSVKEVTDRIDGPDFTVQKVEKKERKRNPAnPFTTSSLQQEA 264
Cdd:PRK08173 222 VRAEFvaaagfyegRWFDPKFKKDEFDPEKRASRLWSEAAAEAIVAACRGKPGTVTEESKPSTQLSPL-LFDLTSLQREA 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 265 ARKLNFRTRKTMMVAQQLYEgislgKQGtvgLITYMRTDSTRIAETAKAEAATFIEE-TYGKEFSSHAQ----------- 332
Cdd:PRK08173 301 NGRFGFSAKNTLGLAQALYE-----KHK---VLTYPRTDSRALPEDYLGTVKQTLEMlKESNNYLPHAKqildkgwvkpn 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 333 RKIKNAQGAQDaHEAVRPTsvLRTPeeikQYLDKDQLKLYTLIWSRFVASQMTPA-ILDTMKVTlEQNGVLFIANGsKVK 411
Cdd:PRK08173 373 KRIFDNSKISD-HFAIIPT--LQAP----KSLSEPEQKLYDLVVKRFLAVFFPAAeFLVTTRIT-EVAGHHFKTEG-KVL 443
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 412 FK-GFMQVYveGRDDGKEDKenILPELAQGDIVQSVDIEPKQHFTQPPARFSEATLIRALE----------------ENG 474
Cdd:PRK08173 444 VNpGWLAVY--GKEAQGADA--NLVPVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEgagklveddelreamaEKG 519
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 475 VGRPSTYAPTLDTIQRRYYVKLTQKRFEPT----ELGEIVNSLICdffPQIVDIHFTAEMEGDLDKIEEGKEAWIEvvdr 550
Cdd:PRK08173 520 LGTPATRAAIIEGLLGEKYLVREGRELIPTakafQLMTLLRGLGV---EELTSPELTGEWEYKLSQIERGKLSRDA---- 592
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 551 fykpFEKELTNAEEKIEKiQIKDepagFDCD-ICGHpmviklgkygkfYACSNFPdcrntkpivkeigvtCPVChEGQVI 629
Cdd:PRK08173 593 ----FMQEIAQMTQQIVK-RAKE----YDSDtIPGD------------YATLQTP---------------CPNC-GGVVK 635
|
730 740 750 760
....*....|....*....|....*....|....*....|....*.
gi 1948584369 630 ERKSKknrifYGCSrfpDCDFTSWDKPVGR--NCPKCDQYLVEKKV 673
Cdd:PRK08173 636 ENYRR-----FACT---KCDFSISKIPGGRqfEIAEVEELLRKKEI 673
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
4-541 |
1.84e-24 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 109.27 E-value: 1.84e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 4 KYLVIVESPAKAKTI---------------EKYLGRNYKVMASVGHIRDLpKSKMGIDVENN--------YEPHYISIRG 60
Cdd:PRK14724 2 KTLVIAEKPSVAQDIvraltpvagkfekhdEHFESDSYVVTSAVGHLVEI-QAPEEFDVKRGkwsfanlpVIPPYFDLKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 61 KGDVIKSLKSAAKKAQK-----VYLASDPDREGEAIAWHLAYLLGLDLSEKNRVV----FNEITKEAVKAAFKEPRTID- 130
Cdd:PRK14724 81 VDKTKTRLNAVVKLAKRkdvteLVNACDAGREGELIFRLIEQYAGGAKGGLGKPVkrlwLQSMTPQAIRDGFDNLRSDAq 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 131 -VDLVDAQQARRALDRLVGYSISPIL--WRKVKKGL---SAGRVQSIALKIIIDREKEIRDFIPEEYWSIDGNFKKTRKK 204
Cdd:PRK14724 161 mQGLASAARSRSEADWLVGINGTRAMtaFNSRDGGFfltTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIHAGFHAEAGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 205 FKANfWGIDGKKKKLPDAQS----------VKEVTDRIDGPDFTVQKvEKKERKRNPANPFTTSSLQQEAARKLNFRTRK 274
Cdd:PRK14724 241 YLGK-WFDPQWKKASDDPEAradrvwsereARAIADAVRGKAATVTE-ESKPTTQASPLLFDLTSLQREANGKFGFSAKT 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 275 TMMVAQQLYEGISlgkqgtvgLITYMRTDSTRIAET---AKAEAATFIEETYGKEFSSHAQRKIKNA----------QGA 341
Cdd:PRK14724 319 TLALAQSLYERHK--------ALTYPRTDSRALPEDylpVAKQTFEMLATSGMRHLAPFAQQALDGNyvrpskrifdNSK 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 342 QDAHEAVRPTsvLRTPEEikqyLDKDQLKLYTLIWSRFVAS-------QMTPAILDTMKVTLEQNGvlfiangsKVKFK- 413
Cdd:PRK14724 391 VSDHFAIIPT--TQAPSG----LSEAEQKLYDLVVRRFMAVffpsaeyQVTTRISQVVGHSFKTEG--------KVLVKp 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 414 GFMQVY----VEGRDDGKE-DKENILPELAQGDIVQSVDIEPKQHFTQPPARFSEATLIRALE----------------E 472
Cdd:PRK14724 457 GWLAIYgkeaANEVEDAKDgDKGQPLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMEsagkqidddelreamqE 536
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1948584369 473 NGVGRPSTYAPTLDTIQRRYYVKLTQKRFEPT----ELGEIVNSLICDffpQIVDIHFTAEMEGDLDKIEEGK 541
Cdd:PRK14724 537 KGLGTPATRAAIIEGLLTEKYMLREGRELIPTakafQLMTLLRGLGVE---ELSRAELTGEWEYKLAQMEKGQ 606
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
6-114 |
2.34e-22 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 91.65 E-value: 2.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 6 LVIVESPAKAKTIEKYLGRNYK-VMASVGHIRDLPKskmgidvennyephyisiRGKGDVIKSLKSAAKKAQKVYLASDP 84
Cdd:pfam01751 2 LIIVEGPSDAIALEKALGGGFQaVVAVLGHLLSLEK------------------GPKKKALKALKELALKAKEVILATDP 63
|
90 100 110
....*....|....*....|....*....|
gi 1948584369 85 DREGEAIAWHLAYLLGLDLSEKNRVVFNEI 114
Cdd:pfam01751 64 DREGEAIALKLLELKELLENAGGRVEFSEL 93
|
|
| TOPRIM_TopoIA_RevGyr |
cd03361 |
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA ... |
6-126 |
2.92e-21 |
|
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173781 [Multi-domain] Cd Length: 170 Bit Score: 91.22 E-value: 2.92e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 6 LVIVESPAKAKTIEKYLGR-------------------NYKVMASVGHIRDLPKSKMGIDVENN---YEPHYISIR---- 59
Cdd:cd03361 3 LMIVESPNKARTIANFFGRpsvrrlgglvvyevstgdgVLMITASGGHVYDLVTKEGGHGVVEDdgrYVPVYDSIKrcrd 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 60 ---------------------GKGDVIKSLKSAAKKAQKVYLASDPDREGEAIAWHLAYLLGLDLSEKNRVVFNEITKEA 118
Cdd:cd03361 83 cgyqftedsdkcprcgsenidDKLETLEALRELALEVDEVLIATDPDTEGEKIAWDVYLALRPYNKNIKRAEFHEVTRRA 162
|
....*...
gi 1948584369 119 VKAAFKEP 126
Cdd:cd03361 163 ILEALRNP 170
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
4-100 |
1.96e-16 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 74.22 E-value: 1.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 4 KYLVIVESPAKAKTIEKYLGRNYKVMASVGHIRDLpkskmgidvennyephyisirgkgDVIKSLKSAAKKAQkVYLASD 83
Cdd:smart00493 1 KVLIIVEGPADAIALEKAGGKRGNVVALGGHLLSK------------------------EQIKLLKKLAKKAE-VILATD 55
|
90
....*....|....*..
gi 1948584369 84 PDREGEAIAWHLAYLLG 100
Cdd:smart00493 56 PDREGEAIAWELAELLK 72
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
4-126 |
4.30e-13 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 67.26 E-value: 4.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 4 KYLVIVESPAKAKTIEKYLGR------------------NYKVMASVGHIrdlpkskMGIDVENNYEPH----------- 54
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILGGgskkkgkgryyefygeggGYVVTWASGHL-------LELDFPEEYDPWdkvwpledplf 73
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1948584369 55 -----YISIRGKGDVIKSLKSAAKKAQKVYLASDPDREGEAIAWHLAYLLGLDLSEK-NRVVFNEITKEAVKAAFKEP 126
Cdd:cd03362 74 papfkLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVKRKPvKRAWFSSLTPKAIRRAFKNL 151
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
579-614 |
1.24e-12 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 62.28 E-value: 1.24e-12
10 20 30
....*....|....*....|....*....|....*.
gi 1948584369 579 DCDICGHPMVIKLGKYGKFYACSNFPDCRNTKPIVK 614
Cdd:pfam01396 3 KCPKCGGDLVLKRGRFGKFVGCSNYPECRFTRPLKK 38
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
4-111 |
4.71e-12 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 62.06 E-value: 4.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1948584369 4 KYLVIVESPAKAKTIEKYLGRNYKVMASVGHIRDlpkskmgidvennyephyisirgkgDVIKSLKSAAKKAQKVYLASD 83
Cdd:cd00188 1 KKLIIVEGPSDALALAQAGGYGGAVVALGGHALN-------------------------KTRELLKRLLGEAKEVIIATD 55
|
90 100
....*....|....*....|....*...
gi 1948584369 84 PDREGEAIAWHLAYLLGLDLSEKNRVVF 111
Cdd:cd00188 56 ADREGEAIALRLLELLKSLGKKVRRLLL 83
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
617-656 |
2.38e-08 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 50.33 E-value: 2.38e-08
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1948584369 617 GVTCPVCHeGQVIERKSKKNRiFYGCSRFPDCDFTSWDKP 656
Cdd:pfam01396 1 GGKCPKCG-GDLVLKRGRFGK-FVGCSNYPECRFTRPLKK 38
|
|
| |
