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Conserved domains on  [gi|1954979033|gb|QQN83805|]
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type III pantothenate kinase [Bacillus toyonensis]

Protein Classification

type III pantothenate kinase( domain architecture ID 10014195)

type III pantothenate kinase catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis

CATH:  3.30.420.40
EC:  2.7.1.33
Gene Ontology:  GO:0005524|GO:0016310|GO:0004594|GO:0046872|GO:0015937
PubMed:  16905099|8800467|7781919
SCOP:  3000092

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13318 PRK13318
type III pantothenate kinase;
1-257 1.91e-166

type III pantothenate kinase;


:

Pssm-ID: 237347 [Multi-domain]  Cd Length: 258  Bit Score: 460.38  E-value: 1.91e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   1 MIFVLDVGNTNAVLGVFQDGELRQHWRMETDRHKTEDEYGMLVKQLLEHEGLSFEDVKGIIVSSVVPPIMFALERMCEKY 80
Cdd:PRK13318    1 MLLAIDVGNTNTVFGLYEGGKLVAHWRISTDSRRTADEYGVWLKQLLGLSGLDPEDITGIIISSVVPSVMHSLERMCRKY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  81 FKIKP-LVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAE 159
Cdd:PRK13318   81 FNIEPlVVVGPGVKTGINIKVDNPKEVGADRIVNAVAAYELYGGPLIVVDFGTATTFDVVSAKGEYLGGVIAPGINISAD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 160 ALYSRAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNVIDIVDP 239
Cdd:PRK13318  161 ALFQRAAKLPRVEITKPDSVIGKNTVEAMQSGIYYGYVGLVEGIVKRIKEELGKDPKVIATGGLAPLFAEESDTIDIVDP 240

                         250
                  ....*....|....*...
gi 1954979033 240 FLTLKGLYMLYERNANLQ 257
Cdd:PRK13318  241 DLTLKGLRLIYERNKELQ 258
 
Name Accession Description Interval E-value
PRK13318 PRK13318
type III pantothenate kinase;
1-257 1.91e-166

type III pantothenate kinase;


Pssm-ID: 237347 [Multi-domain]  Cd Length: 258  Bit Score: 460.38  E-value: 1.91e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   1 MIFVLDVGNTNAVLGVFQDGELRQHWRMETDRHKTEDEYGMLVKQLLEHEGLSFEDVKGIIVSSVVPPIMFALERMCEKY 80
Cdd:PRK13318    1 MLLAIDVGNTNTVFGLYEGGKLVAHWRISTDSRRTADEYGVWLKQLLGLSGLDPEDITGIIISSVVPSVMHSLERMCRKY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  81 FKIKP-LVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAE 159
Cdd:PRK13318   81 FNIEPlVVVGPGVKTGINIKVDNPKEVGADRIVNAVAAYELYGGPLIVVDFGTATTFDVVSAKGEYLGGVIAPGINISAD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 160 ALYSRAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNVIDIVDP 239
Cdd:PRK13318  161 ALFQRAAKLPRVEITKPDSVIGKNTVEAMQSGIYYGYVGLVEGIVKRIKEELGKDPKVIATGGLAPLFAEESDTIDIVDP 240

                         250
                  ....*....|....*...
gi 1954979033 240 FLTLKGLYMLYERNANLQ 257
Cdd:PRK13318  241 DLTLKGLRLIYERNKELQ 258
CoaX COG1521
Pantothenate kinase type III [Coenzyme transport and metabolism];
1-254 6.72e-144

Pantothenate kinase type III [Coenzyme transport and metabolism];


Pssm-ID: 441130 [Multi-domain]  Cd Length: 250  Bit Score: 403.00  E-value: 6.72e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   1 MIFVLDVGNTNAVLGVFQDGELRQHWRMETDRHkTEDEYGMLVKQLLEHEglsFEDVKGIIVSSVVPPIMFALERMCEKY 80
Cdd:COG1521     1 MLLAIDIGNTRIKWGLFDGGELLASWRLATDRR-TADELAELLRQLLAAL---LPDIEGVIISSVVPPLTEALEELLRKY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  81 FKIKPLVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEA 160
Cdd:COG1521    77 FGVPPLVVGPGVKTGLKNAYDNPEELGADRIANAVAARELYGGPLLVVDFGTATTFDVVDADGEYLGGAIAPGLGLSLEA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 161 LYSRAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNVIDIVDPF 240
Cdd:COG1521   157 LHQRTAKLPLVELEKPPSVIGKNTVEAIQSGVVYGYAGLIEGLIERIKEELGEDPKVIATGGDAPLLAPELKTIDIVDPD 236

                         250
                  ....*....|....
gi 1954979033 241 LTLKGLYMLYERNA 254
Cdd:COG1521   237 LVLEGLRLIYERNK 250
ASKHA_NBD_PanK-III cd24015
nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar ...
 4-249 1.54e-119

nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar proteins; PanK (EC 2.7.1.33), also called pantothenic acid kinase, is the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. It catalyzes the phosphorylation of pantothenate (vitamin B5) to form 4'-phosphopantothenate at the expense of a molecule of adenosine triphosphate (ATP), which is the rate-limiting step in CoA biosynthesis. It cannot utilize a phosphoryl donor other than ATP. Three distinct types of PanK have been identified, PanK-I, PanK-II and PanK-III. The model corresponds to PanK-III that belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466865 [Multi-domain]  Cd Length: 241  Bit Score: 341.17  E-value: 1.54e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   4 VLDVGNTNAVLGVFQDGELRQHWRMETDRHKTEDEYGmlvkqlLEHEGLSFEDVKGIIVSSVVPPIMFALERMCEKYFKI 83
Cdd:cd24015     2 VIDIGNTNIKLGLFDGGELVKIWRLSTDKELTEDELL------LLLAGIELEDISGVVISSVVPSLTEVLEEALKKYFGI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  84 KPLVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYS 163
Cdd:cd24015    76 SPLVVGPGLKLGVKIAYDNPKELGADRLANAVAAAKLYGRPVIVVDFGTATTIDLVDAEGEFLGGAIAPGIELSLKALHQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 164 RAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNVIDIVDPFLTL 243
Cdd:cd24015   156 RTAKLPSVELIKPKKVIGKNTEEAIQSGVFYGYAGLIEGIIERLKKELGGDAKVILTGGDAKLVAPYLEPIDIYDPDLTL 235


                  ....*.
gi 1954979033 244 KGLYML 249
Cdd:cd24015   236 KGLKLI 241
Pan_kinase pfam03309
Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of ...
 2-206 3.63e-115

Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.


Pssm-ID: 460881 [Multi-domain]  Cd Length: 205  Bit Score: 328.75  E-value: 3.63e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   2 IFVLDVGNTNAVLGVFQDGELRQHWRMETDRHKTEDEYGMLVKQLLEHEGLSFedVKGIIVSSVVPPIMFALERMCEKYF 81
Cdd:pfam03309   1 LLAIDIGNTNIKWGLFDGDKLVAHWRISTDARRTADELGVLLRSLLRLAGIDP--IDGVIISSVVPPLNAALERACLKYF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  82 KIKPLVVG-PGIKTGLNIKYENPREVGADRIVNAVAGIHLY-GSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAE 159
Cdd:pfam03309  79 KIEPLVVGaPGIKTGLRNRYDNPKELGADRWVNAVAARELYpGKPLIVVDFGTATTFDAVSADGEYLGGAIAPGIGLSLD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1954979033 160 ALYSRAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKR 206
Cdd:pfam03309 159 ALAQGTAKLPRVEITRPGSVIGKNTVEAIQSGILYGYAGLVEGIIRR 205
baf TIGR00671
pantothenate kinase, type III; This model describes a family of proteins found in a single ...
 4-246 7.83e-100

pantothenate kinase, type III; This model describes a family of proteins found in a single copy in at least ten different early completed bacterial genomes. The only characterized member of the family is Bvg accessory factor (Baf), a protein required, in addition to the regulatory operon bvgAS, for heterologous transcription of the Bordetella pertussis toxin operon (ptx) in E. coli. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273210 [Multi-domain]  Cd Length: 243  Bit Score: 291.30  E-value: 7.83e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   4 VLDVGNTNAVLGVFQDGELRQHWRMETDRHKTEDEYGMLVKQLLEHeglsfeDVKGIIVSSVVPPIMFALERMCEKYFKI 83
Cdd:TIGR00671   3 LIDVGNTRIVFALNSGNKVYQFWRLATNLMKTYDEHSEFLKELFGK------SLNKAFISSVVPELTEAVRNMIPKIKNI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  84 KPLVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYS 163
Cdd:TIGR00671  77 KPEIFFPLVYDGLPNLYKSPKELGIDRVANALAAIKFYGFNVVVVDAGTALTIDLVDQEGKFLGGAIAPGLGISLHALKD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 164 RAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNViDIVDPFLTL 243
Cdd:TIGR00671 157 RAAALPKFEIARPDEVLGKSTREAVQSGAVYGVLGLIQGLLKDWKKYFKRKFAVVITGGDGKYLSAFLPF-SIYDPHLTV 235


                  ...
gi 1954979033 244 KGL 246
Cdd:TIGR00671 236 EGM 238
 
Name Accession Description Interval E-value
PRK13318 PRK13318
type III pantothenate kinase;
1-257 1.91e-166

type III pantothenate kinase;


Pssm-ID: 237347 [Multi-domain]  Cd Length: 258  Bit Score: 460.38  E-value: 1.91e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   1 MIFVLDVGNTNAVLGVFQDGELRQHWRMETDRHKTEDEYGMLVKQLLEHEGLSFEDVKGIIVSSVVPPIMFALERMCEKY 80
Cdd:PRK13318    1 MLLAIDVGNTNTVFGLYEGGKLVAHWRISTDSRRTADEYGVWLKQLLGLSGLDPEDITGIIISSVVPSVMHSLERMCRKY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  81 FKIKP-LVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAE 159
Cdd:PRK13318   81 FNIEPlVVVGPGVKTGINIKVDNPKEVGADRIVNAVAAYELYGGPLIVVDFGTATTFDVVSAKGEYLGGVIAPGINISAD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 160 ALYSRAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNVIDIVDP 239
Cdd:PRK13318  161 ALFQRAAKLPRVEITKPDSVIGKNTVEAMQSGIYYGYVGLVEGIVKRIKEELGKDPKVIATGGLAPLFAEESDTIDIVDP 240

                         250
                  ....*....|....*...
gi 1954979033 240 FLTLKGLYMLYERNANLQ 257
Cdd:PRK13318  241 DLTLKGLRLIYERNKELQ 258
PRK13321 PRK13321
type III pantothenate kinase;
1-253 2.98e-148

type III pantothenate kinase;


Pssm-ID: 237349 [Multi-domain]  Cd Length: 256  Bit Score: 414.27  E-value: 2.98e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   1 MIFVLDVGNTNAVLGVFQDGELRQHWRMETDRHKTEDEYGMLVKQLLEHEGLSFEDVKGIIVSSVVPPIMFALERMCEKY 80
Cdd:PRK13321    1 MLLLIDVGNTNIKLGVFDGDRLLRSFRLPTDKSRTSDELGILLLSLFRHAGLDPEDIRAVVISSVVPPLNYSLESACKRY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  81 FKIKPLVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSP-LIIVDFGTATTYCYINEEKHYMGGVITPGIMISAE 159
Cdd:PRK13321   81 FGIKPLFVGPGIKTGLKIRYDNPREVGADRIVNAVAARRLYPDRnLIVVDFGTATTFDCVSGKGEYLGGAICPGILISME 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 160 ALYSRAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNVIDIVDP 239
Cdd:PRK13321  161 ALSQKTAKLPRVEIAKPPSAIGKSTVSSIQSGLYYGYAGLVEGIVARIKAELGGPPRVIATGGFASLIAKESRCFDHVDP 240

                         250
                  ....*....|....
gi 1954979033 240 FLTLKGLYMLYERN 253
Cdd:PRK13321  241 DLLLEGLRILYQMN 254
CoaX COG1521
Pantothenate kinase type III [Coenzyme transport and metabolism];
1-254 6.72e-144

Pantothenate kinase type III [Coenzyme transport and metabolism];


Pssm-ID: 441130 [Multi-domain]  Cd Length: 250  Bit Score: 403.00  E-value: 6.72e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   1 MIFVLDVGNTNAVLGVFQDGELRQHWRMETDRHkTEDEYGMLVKQLLEHEglsFEDVKGIIVSSVVPPIMFALERMCEKY 80
Cdd:COG1521     1 MLLAIDIGNTRIKWGLFDGGELLASWRLATDRR-TADELAELLRQLLAAL---LPDIEGVIISSVVPPLTEALEELLRKY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  81 FKIKPLVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEA 160
Cdd:COG1521    77 FGVPPLVVGPGVKTGLKNAYDNPEELGADRIANAVAARELYGGPLLVVDFGTATTFDVVDADGEYLGGAIAPGLGLSLEA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 161 LYSRAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNVIDIVDPF 240
Cdd:COG1521   157 LHQRTAKLPLVELEKPPSVIGKNTVEAIQSGVVYGYAGLIEGLIERIKEELGEDPKVIATGGDAPLLAPELKTIDIVDPD 236

                         250
                  ....*....|....
gi 1954979033 241 LTLKGLYMLYERNA 254
Cdd:COG1521   237 LVLEGLRLIYERNK 250
ASKHA_NBD_PanK-III cd24015
nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar ...
 4-249 1.54e-119

nucleotide-binding domain (NBD) of type III pantothenate kinase (PanK-III) and similar proteins; PanK (EC 2.7.1.33), also called pantothenic acid kinase, is the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. It catalyzes the phosphorylation of pantothenate (vitamin B5) to form 4'-phosphopantothenate at the expense of a molecule of adenosine triphosphate (ATP), which is the rate-limiting step in CoA biosynthesis. It cannot utilize a phosphoryl donor other than ATP. Three distinct types of PanK have been identified, PanK-I, PanK-II and PanK-III. The model corresponds to PanK-III that belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466865 [Multi-domain]  Cd Length: 241  Bit Score: 341.17  E-value: 1.54e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   4 VLDVGNTNAVLGVFQDGELRQHWRMETDRHKTEDEYGmlvkqlLEHEGLSFEDVKGIIVSSVVPPIMFALERMCEKYFKI 83
Cdd:cd24015     2 VIDIGNTNIKLGLFDGGELVKIWRLSTDKELTEDELL------LLLAGIELEDISGVVISSVVPSLTEVLEEALKKYFGI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  84 KPLVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYS 163
Cdd:cd24015    76 SPLVVGPGLKLGVKIAYDNPKELGADRLANAVAAAKLYGRPVIVVDFGTATTIDLVDAEGEFLGGAIAPGIELSLKALHQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 164 RAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNVIDIVDPFLTL 243
Cdd:cd24015   156 RTAKLPSVELIKPKKVIGKNTEEAIQSGVFYGYAGLIEGIIERLKKELGGDAKVILTGGDAKLVAPYLEPIDIYDPDLTL 235


                  ....*.
gi 1954979033 244 KGLYML 249
Cdd:cd24015   236 KGLKLI 241
Pan_kinase pfam03309
Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of ...
 2-206 3.63e-115

Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.


Pssm-ID: 460881 [Multi-domain]  Cd Length: 205  Bit Score: 328.75  E-value: 3.63e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   2 IFVLDVGNTNAVLGVFQDGELRQHWRMETDRHKTEDEYGMLVKQLLEHEGLSFedVKGIIVSSVVPPIMFALERMCEKYF 81
Cdd:pfam03309   1 LLAIDIGNTNIKWGLFDGDKLVAHWRISTDARRTADELGVLLRSLLRLAGIDP--IDGVIISSVVPPLNAALERACLKYF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  82 KIKPLVVG-PGIKTGLNIKYENPREVGADRIVNAVAGIHLY-GSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAE 159
Cdd:pfam03309  79 KIEPLVVGaPGIKTGLRNRYDNPKELGADRWVNAVAARELYpGKPLIVVDFGTATTFDAVSADGEYLGGAIAPGIGLSLD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1954979033 160 ALYSRAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKR 206
Cdd:pfam03309 159 ALAQGTAKLPRVEITRPGSVIGKNTVEAIQSGILYGYAGLVEGIIRR 205
baf TIGR00671
pantothenate kinase, type III; This model describes a family of proteins found in a single ...
 4-246 7.83e-100

pantothenate kinase, type III; This model describes a family of proteins found in a single copy in at least ten different early completed bacterial genomes. The only characterized member of the family is Bvg accessory factor (Baf), a protein required, in addition to the regulatory operon bvgAS, for heterologous transcription of the Bordetella pertussis toxin operon (ptx) in E. coli. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273210 [Multi-domain]  Cd Length: 243  Bit Score: 291.30  E-value: 7.83e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   4 VLDVGNTNAVLGVFQDGELRQHWRMETDRHKTEDEYGMLVKQLLEHeglsfeDVKGIIVSSVVPPIMFALERMCEKYFKI 83
Cdd:TIGR00671   3 LIDVGNTRIVFALNSGNKVYQFWRLATNLMKTYDEHSEFLKELFGK------SLNKAFISSVVPELTEAVRNMIPKIKNI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  84 KPLVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYS 163
Cdd:TIGR00671  77 KPEIFFPLVYDGLPNLYKSPKELGIDRVANALAAIKFYGFNVVVVDAGTALTIDLVDQEGKFLGGAIAPGLGISLHALKD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 164 RAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNViDIVDPFLTL 243
Cdd:TIGR00671 157 RAAALPKFEIARPDEVLGKSTREAVQSGAVYGVLGLIQGLLKDWKKYFKRKFAVVITGGDGKYLSAFLPF-SIYDPHLTV 235


                  ...
gi 1954979033 244 KGL 246
Cdd:TIGR00671 236 EGM 238
PRK13320 PRK13320
type III pantothenate kinase;
1-253 3.07e-58

type III pantothenate kinase;


Pssm-ID: 237348 [Multi-domain]  Cd Length: 244  Bit Score: 185.45  E-value: 3.07e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   1 MIFVLDVGNTNAVLGVFQDGELrqhwrMETDRHKTEDeygmlVKQLLEHEGLSFEDVKGIIVSSVVPPIMFALERMCEKY 80
Cdd:PRK13320    3 MNLVIDIGNTTTKLAVFEGDEL-----LEVFVVSTEG-----VEESLEKLLAKYPAIRDAIVSSVVPLAEEAFSALLKLL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  81 FKIkpLVVGPGIKTGLNIKYENPREVGADRIVNAVAGIHLY-GSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAE 159
Cdd:PRK13320   73 FAV--LELDSETPLPFRNDYDTPETLGADRLALCAGARYLFpGKNVLAIDAGTAITYDVLDSEGVYLGGLISPGLEMRFK 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 160 ALYSRAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEaKQEPKVIATGGLAKLISEESNVIDIVDP 239
Cdd:PRK13320  151 ALHEFTARLPLVTIEGPIPLIGRSTEECIRSGVVWGCVAEIEGLIEAYKSK-LPELLVILTGGDAPFLASRLKNTIFADE 229

                         250
                  ....*....|....
gi 1954979033 240 FLTLKGLYMLYERN 253
Cdd:PRK13320  230 HAVLKGLNRILEYN 243
PRK13324 PRK13324
type III pantothenate kinase;
1-253 1.81e-41

type III pantothenate kinase;


Pssm-ID: 106284 [Multi-domain]  Cd Length: 258  Bit Score: 142.84  E-value: 1.81e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   1 MIFVLDVGNTNAVLGVFQDGELRQHWRMETDR-HKTEDEYGMLVKQLLEHEGLSFEDVKGIIVSSVVPPIMFALERMCEK 79
Cdd:PRK13324    1 MLLVMDMGNSHIHIGVFDGDRIVSQIRYATSSvDSTSDQMGVFLRQALRENSVDLGKIDGCGISSVVPHLNYSLGSAVIK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  80 YFKIKPLVVGPGiKTGLNIKYENPREVGADRIVNAVAGIHLY-GSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISA 158
Cdd:PRK13324   81 YFNIKPFFISMD-TTDLDMSAVEAHQVGADRIASCISAIADHpNKDLLIIDLGTATTFDLVTKDKKYLSGSIMPGVKLSL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 159 EALYSRAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEEsNVIDIVD 238
Cdd:PRK13324  160 NALCQGASQLSSVTIVKPEVAIGYDTKTNIRSGLYYGHLGALKELKRRSVEEFGSPVYTIATGGFAGLFKEE-DIFNEIS 238

                         250
                  ....*....|....*
gi 1954979033 239 PFLTLKGLYMLYERN 253
Cdd:PRK13324  239 PDLILRGIRIAFLEN 253
PRK13322 PRK13322
pantothenate kinase; Reviewed
 1-251 3.22e-29

pantothenate kinase; Reviewed


Pssm-ID: 237350 [Multi-domain]  Cd Length: 246  Bit Score: 110.43  E-value: 3.22e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   1 MIFVLDVGNTNAVLGVFQDGelRQHWrmETDRHKTEDEygmlvKQLLEHEGLSFEDVKGIIVSSVV-PPIMFALERMCEK 79
Cdd:PRK13322    1 MILELDCGNSRLKWRVIDNG--GQII--EHGAHLDSPA-----ELLLGLANLASLAPTRCRIVSVLsEEETARLVAILEK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  80 YFKIKPLVVGP-----GIKTGlnikYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGI 154
Cdd:PRK13322   72 RLGIPVVFAKVaaelaGVRNG----YEDPEQLGIDRWLALLGAFHLAKNACLVIDCGTAVTIDLVDADGQHLGGYICPGL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 155 MISAEALYSRAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNVI 234
Cdd:PRK13322  148 YLMRDALRTHTRRIRYDDGTADSLSPGRNTVDAVERGCLLMLRGFIESQLEQARELWGPDFEIFLTGGDAPLLADHLPQA 227

                         250
                  ....*....|....*..
gi 1954979033 235 dIVDPFLTLKGLYMLYE 251
Cdd:PRK13322  228 -RVVPDLVFVGLAQYCP 243
PRK13326 PRK13326
type III pantothenate kinase;
4-249 4.44e-24

type III pantothenate kinase;


Pssm-ID: 237351  Cd Length: 262  Bit Score: 97.16  E-value: 4.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   4 VLDVGNTNAVLGVFQDGELRQHWRMETDRHKTEDEYGMLVKqllehEGLSFeDVKGIIVSSVVPPIMFALERMCEKYFKI 83
Cdd:PRK13326   10 IIDIGNTSISFALYKDNKMQIFCKLKTKLDLSFDELYSFLK-----EKFDF-KVNQVFVSSVVPVIDKVLINVIFSLYKV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  84 KPLVVGPGIKTGLNIKYENPRE--VGADRIVNAVAGIHLYG-SPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEA 160
Cdd:PRK13326   84 KPLFIGFDLNYDLSFNPYNSNKflLGSDVFANLVGAIEYYNiNDALVVDLGTACTIFAVSRQDGILGGLINGGPFTNLNA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 161 LYSRAAKLPRIEITKPSSVIGKNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNVIDIVDPF 240
Cdd:PRK13326  164 LLDNAYLLKDFNLSVPKNLLGLSTSDSVNSGVIYQYKYLIEGVYHDLKRNYDREFNLIITGGNSNLILPLISVDFIFNLY 243


                  ....*....
gi 1954979033 241 LTLKGLYML 249
Cdd:PRK13326  244 LTLEGIRIL 252
PRK13329 PRK13329
pantothenate kinase; Reviewed
 95-246 7.62e-20

pantothenate kinase; Reviewed


Pssm-ID: 183979 [Multi-domain]  Cd Length: 249  Bit Score: 85.43  E-value: 7.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  95 GLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYSRAAKLPrieit 174
Cdd:PRK13329   91 GVRNGYDHPARLGADRWVALIGARHGPARPCLVVMVGTAVTVDALDADGEFLGGLILPGHGLMLRALESGTAGLH----- 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1954979033 175 KPSSVIG---KNTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLAKLISEESNV-IDIVDPfLTLKGL 246
Cdd:PRK13329  166 VPTGEVRefpTNTSDALTSGGTQAIAGAVERMFRHLAQHCGAEPECLLTGGAAWKLAPSLTVpFELVDN-LVLDGL 240
PRK13331 PRK13331
pantothenate kinase; Reviewed
 3-246 1.26e-19

pantothenate kinase; Reviewed


Pssm-ID: 237353 [Multi-domain]  Cd Length: 251  Bit Score: 85.10  E-value: 1.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   3 FVLDVGNTNAVLGVFQDGELRQHWrmETDRHKTEDeygmlVKQLLEHEGLSFEDVKGIIVSSVVPpimfalermceKYFK 82
Cdd:PRK13331   10 LALMIGNSRLHWGYFSGETLVKTW--DTPHLDESI-----IQLLLPGQTLLIVAPNPLVIASVVP-----------QQTE 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  83 IKPLVVGPGIKTGLNIKYENP-REVGADRIVNAV-AGIHlYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEA 160
Cdd:PRK13331   72 LWQTYPNVRLITLDDIPLNNLyPTLGIDRALALWgAGQT-YGFPCLVIDAGTALTFTGVDSDRTLVGGAILPGLGLQLRS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 161 LYSRAAKLPRIEITKP-SSVIGKNTVSAMQSGILYGYVGqveGIVKRMKEEAKQEP--KVIATGGLAKLISE-------E 230
Cdd:PRK13331  151 LADKTAALPQVELPPPlPPRWATNTQEAIQSGVIYTILA---GLRDFIEDWLSLFPdgKIVLTGGDGELLHNylqdldpE 227

                         250
                  ....*....|....*.
gi 1954979033 231 SNVIDIVDPFLTLKGL 246
Cdd:PRK13331  228 LAQRLRVDPNLIFWGI 243
PRK13328 PRK13328
type III pantothenate kinase;
100-224 5.96e-14

type III pantothenate kinase;


Pssm-ID: 237352 [Multi-domain]  Cd Length: 255  Bit Score: 69.66  E-value: 5.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 100 YENPREVGADRIVNAVAGIHLY-GSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYSRAAKLPRIEITKPSS 178
Cdd:PRK13328   94 YREPAQLGSDRWAGLIGARAAFpGEHLLIATFGTATTLDALRADGRFAGGLILPGLALMMRALARHTAQLPTLDVDAASA 173

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1954979033 179 VIGK------NTVSAMQSGILYGYVGQVEGIVKRMKEEAKQEPKVIATGGLA 224
Cdd:PRK13328  174 AAGAvapfadDTPDAISAGCLAAQAGLIERAWRDLAARWQAPVRLVLSGGAA 225
PRK13325 PRK13325
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase;
95-229 6.98e-12

bifunctional biotin--[acetyl-CoA-carboxylase] ligase/type III pantothenate kinase;


Pssm-ID: 183976 [Multi-domain]  Cd Length: 592  Bit Score: 65.12  E-value: 6.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  95 GLNIKYENPREVGADRIVNAVAGIHLYGSPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYSRAAKLPRIEIT 174
Cdd:PRK13325  421 GIRNHYRHPEEHGSDRWFNALGSRRFSRNACVVVSCGTAVTVDALTDDGHYLGGTIMPGFHLMKESLAVRTANLNRHAGK 500

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 175 K---PSSvigknTVSAMQSGILYGYVGQVEGIVKRMKEE--AKQEPKVIATGGLAKLISE 229
Cdd:PRK13325  501 RypfPTT-----TGNAVASGMMDAVCGSVMMMHGRLKEKtgAGKPVDVIITGGGAAKVAE 555
PRK13327 PRK13327
type III pantothenate kinase;
95-169 1.42e-05

type III pantothenate kinase;


Pssm-ID: 183977 [Multi-domain]  Cd Length: 242  Bit Score: 45.21  E-value: 1.42e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1954979033  95 GLNIKYENPREVGADRIVnAVAGIHLYGsPLIIVDFGTATTYCYINEEKHYMGGVITPGIMISAEALYSRAAKLP 169
Cdd:PRK13327   86 GVRIAYADPSRFGVDRFL-ALLGARGDA-PVLVVGVGTALTIDLLGADGLHHGGRIAASPTTMREALHARAVQLP 158
PRK13333 PRK13333
type III pantothenate kinase;
1-246 2.29e-05

type III pantothenate kinase;


Pssm-ID: 183981 [Multi-domain]  Cd Length: 206  Bit Score: 44.15  E-value: 2.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033   1 MIFVlDVGNTNAvlGVFQDGelrQHWRMETDrhktedeygmlvkqllehEGLSFEDVKGIIVSSVVPPIMFALERMCEKY 80
Cdd:PRK13333    1 MLLC-DIGNTNA--HFYQNG---KIFSLSIE------------------EFKRFKIDQEIYYISVNEELEKKLLKCYPNA 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033  81 FKIKPLVVgpgiktgLNIKYENpreVGADRIVNAVA---GIhlygspliIVDFGTATTYCYINEEKHyMGGVITPGIMIS 157
Cdd:PRK13333   57 INLEPYFE-------LDTIYQG---LGIDRIAACYAiedGV--------VVDAGSAITVDIMSNGIH-LGGFILPGIAAY 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1954979033 158 AEALYSRAAKL-----PRIEITKpssvIGKNTVSAMQsgilYGYVGQvegiVKRMKEEAKQEPKVIATGGLAKLIS---E 229
Cdd:PRK13333  118 KKAYKKISPRLkqpfnAQISLDA----LPQNTRDAIS----YGVIKS----IILLIEKLAKNKKIYFTGGDGKFLSkffP 185

                         250
                  ....*....|....*..
gi 1954979033 230 ESnvidIVDPFLTLKGL 246
Cdd:PRK13333  186 NA----IYDERLVFRGM 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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