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Conserved domains on  [gi|1986027643|gb|QRP12696|]
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glycosyltransferase [Haemophilus parahaemolyticus]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10135928)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  10521532|12691742|9445404|12200473|10508766
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 4-203 2.24e-107

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


:

Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 308.86  E-value: 2.24e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   4 SVLMSLYIKENPQYLKECFESLKNQTLPATEIVVLFDGAVTTELEAIVTEYEAILPIKAVKFPQNRGLGKTLNDGLNYCR 83
Cdd:cd04195     1 SVLMSVYIKEKPEFLREALESILKQTLPPDEVVLVKDGPVTQSLNEVLEEFKRKLPLKVVPLEKNRGLGKALNEGLKHCT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  84 HEWVFRMDTDDICVPERFEKQAKFIQQHPDVIMLGGQIAEFGENINDIVAYRnVPTSQEEIVRFTRLRCPFNHMTVAYKK 163
Cdd:cd04195    81 YDWVARMDTDDISLPDRFEKQLDFIEKNPEIDIVGGGVLEFDSDGNDIGKRR-LPTSHDDILKFARRRSPFNHPTVMFRK 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1986027643 164 SKVLECGGYQG--LQEDYTLWIKMLATGLNVANLSDILVYAR 203
Cdd:cd04195   160 SKVLAVGGYQDlpLVEDYALWARMLANGARFANLPEILVKAR 201
 
Name Accession Description Interval E-value
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 4-203 2.24e-107

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 308.86  E-value: 2.24e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   4 SVLMSLYIKENPQYLKECFESLKNQTLPATEIVVLFDGAVTTELEAIVTEYEAILPIKAVKFPQNRGLGKTLNDGLNYCR 83
Cdd:cd04195     1 SVLMSVYIKEKPEFLREALESILKQTLPPDEVVLVKDGPVTQSLNEVLEEFKRKLPLKVVPLEKNRGLGKALNEGLKHCT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  84 HEWVFRMDTDDICVPERFEKQAKFIQQHPDVIMLGGQIAEFGENINDIVAYRnVPTSQEEIVRFTRLRCPFNHMTVAYKK 163
Cdd:cd04195    81 YDWVARMDTDDISLPDRFEKQLDFIEKNPEIDIVGGGVLEFDSDGNDIGKRR-LPTSHDDILKFARRRSPFNHPTVMFRK 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1986027643 164 SKVLECGGYQG--LQEDYTLWIKMLATGLNVANLSDILVYAR 203
Cdd:cd04195   160 SKVLAVGGYQDlpLVEDYALWARMLANGARFANLPEILVKAR 201
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-216 4.24e-28

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 106.71  E-value: 4.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   1 MEFSVLMSLYikeN-PQYLKECFESLKNQTLPATEIVVLFDGAvTTELEAIVTEYEAILP-IKAVKFPQNRGLGKTLNDG 78
Cdd:COG0463     2 PLVSVVIPTY---NeEEYLEEALESLLAQTYPDFEIIVVDDGS-TDGTAEILRELAAKDPrIRVIRLERNRGKGAARNAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  79 LNYCRHEWVFRMDTDDICVPERFEKQAKFIQQHPDVIMLGGQIAEFGEnindiVAYRNVPTSQEEIVRFTRLRCPFNHMT 158
Cdd:COG0463    78 LAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLIREGE-----SDLRRLGSRLFNLVRLLTNLPDSTSGF 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1986027643 159 VAYKKSKVLECGGYQGLQEDYTLwIKMLATGLNVANLSdilVYARVGNGMVGRRRGWK 216
Cdd:COG0463   153 RLFRREVLEELGFDEGFLEDTEL-LRALRHGFRIAEVP---VRYRAGESKLNLRDLLR 206
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-135 1.55e-22

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 90.92  E-value: 1.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   4 SVLMSLYIKEnpQYLKECFESLKNQTLPATEIVVLFDGAvTTELEAIVTEYEAILP-IKAVKFPQNRGLGKTLNDGLNYC 82
Cdd:pfam00535   1 SVIIPTYNEE--KYLLETLESLLNQTYPNFEIIVVDDGS-TDGTVEIAEEYAKKDPrVRVIRLPENRGKAGARNAGLRAA 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1986027643  83 RHEWVFRMDTDDICVPERFEKQAKFIQQHPDVIMLGGQIAEFGENINDIVAYR 135
Cdd:pfam00535  78 TGDYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASR 130
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 4-103 3.48e-06

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 47.35  E-value: 3.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   4 SVLMSLYIKENpqYLKECFESLKNQTLPATEIVVLFDGAvTTELEAIVTEYEAILPIKAVKFPQNRGLGKTLNDGLNYCR 83
Cdd:PRK10073    9 SIIIPLYNAGK--DFRAFMESLIAQTWTALEIIIVNDGS-TDNSVEIAKHYAENYPHVRLLHQANAGVSVARNTGLAVAT 85

                          90       100
                  ....*....|....*....|
gi 1986027643  84 HEWVFRMDTDDICVPERFEK 103
Cdd:PRK10073   86 GKYVAFPDADDVVYPTMYET 105
 
Name Accession Description Interval E-value
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 4-203 2.24e-107

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 308.86  E-value: 2.24e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   4 SVLMSLYIKENPQYLKECFESLKNQTLPATEIVVLFDGAVTTELEAIVTEYEAILPIKAVKFPQNRGLGKTLNDGLNYCR 83
Cdd:cd04195     1 SVLMSVYIKEKPEFLREALESILKQTLPPDEVVLVKDGPVTQSLNEVLEEFKRKLPLKVVPLEKNRGLGKALNEGLKHCT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  84 HEWVFRMDTDDICVPERFEKQAKFIQQHPDVIMLGGQIAEFGENINDIVAYRnVPTSQEEIVRFTRLRCPFNHMTVAYKK 163
Cdd:cd04195    81 YDWVARMDTDDISLPDRFEKQLDFIEKNPEIDIVGGGVLEFDSDGNDIGKRR-LPTSHDDILKFARRRSPFNHPTVMFRK 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1986027643 164 SKVLECGGYQG--LQEDYTLWIKMLATGLNVANLSDILVYAR 203
Cdd:cd04195   160 SKVLAVGGYQDlpLVEDYALWARMLANGARFANLPEILVKAR 201
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-216 4.24e-28

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 106.71  E-value: 4.24e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   1 MEFSVLMSLYikeN-PQYLKECFESLKNQTLPATEIVVLFDGAvTTELEAIVTEYEAILP-IKAVKFPQNRGLGKTLNDG 78
Cdd:COG0463     2 PLVSVVIPTY---NeEEYLEEALESLLAQTYPDFEIIVVDDGS-TDGTAEILRELAAKDPrIRVIRLERNRGKGAARNAG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  79 LNYCRHEWVFRMDTDDICVPERFEKQAKFIQQHPDVIMLGGQIAEFGEnindiVAYRNVPTSQEEIVRFTRLRCPFNHMT 158
Cdd:COG0463    78 LAAARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLIREGE-----SDLRRLGSRLFNLVRLLTNLPDSTSGF 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1986027643 159 VAYKKSKVLECGGYQGLQEDYTLwIKMLATGLNVANLSdilVYARVGNGMVGRRRGWK 216
Cdd:COG0463   153 RLFRREVLEELGFDEGFLEDTEL-LRALRHGFRIAEVP---VRYRAGESKLNLRDLLR 206
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-135 1.55e-22

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 90.92  E-value: 1.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   4 SVLMSLYIKEnpQYLKECFESLKNQTLPATEIVVLFDGAvTTELEAIVTEYEAILP-IKAVKFPQNRGLGKTLNDGLNYC 82
Cdd:pfam00535   1 SVIIPTYNEE--KYLLETLESLLNQTYPNFEIIVVDDGS-TDGTVEIAEEYAKKDPrVRVIRLPENRGKAGARNAGLRAA 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1986027643  83 RHEWVFRMDTDDICVPERFEKQAKFIQQHPDVIMLGGQIAEFGENINDIVAYR 135
Cdd:pfam00535  78 TGDYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASR 130
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 3-257 7.21e-22

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 92.11  E-value: 7.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   3 FSVLMSLYiKEnPQYLKECFESLKNQTLPAT--EIVVLFDGAvTTELEAIVTEYEAILP-IKAVKFPQNRGLGKTLNDGL 79
Cdd:COG1215    31 VSVIIPAY-NE-EAVIEETLRSLLAQDYPKEklEVIVVDDGS-TDETAEIARELAAEYPrVRVIERPENGGKAAALNAGL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  80 NYCRHEWVFRMDTDDICVPERFEKQAKFIqQHPDVIMLGGqiaefgenindivayrnvptsqeeivrftrlrcpfnhmTV 159
Cdd:COG1215   108 KAARGDIVVFLDADTVLDPDWLRRLVAAF-ADPGVGASGA--------------------------------------NL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643 160 AYKKSKVLECGGYQG--LQEDYTLWIKMLATGLNVANLSDILVYARVGNGMVGRRRGWKQFQYEWELYRLKNQvKIQSPI 237
Cdd:COG1215   149 AFRREALEEVGGFDEdtLGEDLDLSLRLLRAGYRIVYVPDAVVYEEAPETLRALFRQRRRWARGGLQLLLKHR-PLLRPR 227

                         250       260
                  ....*....|....*....|
gi 1986027643 238 SGIAIFFMRAIPRILPLSLL 257
Cdd:COG1215   228 RLLLFLLLLLLPLLLLLLLL 247
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 15-120 9.97e-19

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 80.63  E-value: 9.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  15 PQYLKECFESLKNQTLPATEIVVLFDGAVTTELEAIVTEYEAILPIKAVKFPQNRGLGKTLNDGLNYCRHEWVFRMDTDD 94
Cdd:cd00761     9 EPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRVINEENQGLAAARNAGLKAARGEYILFLDADD 88

                          90       100
                  ....*....|....*....|....*.
gi 1986027643  95 ICVPERFEKQAKFIQQHPDVIMLGGQ 120
Cdd:cd00761    89 LLLPDWLERLVAELLADPEADAVGGP 114
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-101 7.80e-11

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 60.01  E-value: 7.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   1 MEFSVLMSLYikENPQYLKECFESLKNQTLPATEIVVLfDGAVTTELEAIVTEYEAiLPIKAVKFPQNRGLGKTLNDGLN 80
Cdd:COG1216     3 PKVSVVIPTY--NRPELLRRCLESLLAQTYPPFEVIVV-DNGSTDGTAELLAALAF-PRVRVIRNPENLGFAAARNLGLR 78

                          90       100
                  ....*....|....*....|.
gi 1986027643  81 YCRHEWVFRMDtDDICVPERF 101
Cdd:COG1216    79 AAGGDYLLFLD-DDTVVEPDW 98
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 3-113 2.38e-10

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 58.37  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   3 FSVLMSLYiKENPQYLKECFESLKNQTLPATEIVVLFDGAVTTELEAIVTEYEAILP-IKAVKFPQNRGLGKTLNDGLNY 81
Cdd:cd04184     3 ISIVMPVY-NTPEKYLREAIESVRAQTYPNWELCIADDASTDPEVKRVLKKYAAQDPrIKVVFREENGGISAATNSALEL 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1986027643  82 CRHEWVFRMDTDDICVPERFEKQAKFIQQHPD 113
Cdd:cd04184    82 ATGEFVALLDHDDELAPHALYEVVKALNEHPD 113
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 14-205 3.04e-10

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 58.33  E-value: 3.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  14 NPQYLKECFESLKNQTLPATEIVVLfDGAVTTELEAIVTEYEAILpIKAVKFPQNrGLGKTLNDGLNYCRHEWVFRMDTD 93
Cdd:cd06433     9 QAETLEETIDSVLSQTYPNIEYIVI-DGGSTDGTVDIIKKYEDKI-TYWISEPDK-GIYDAMNKGIALATGDIIGFLNSD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  94 DICVPERFEKQAKFIQQHPDVIMLGGQIAEFGENINDIVAYRNVPTSqeeiVRFTRLRCPFNHMTVAYKKSKVLECGGYQ 173
Cdd:cd06433    86 DTLLPGALLAVVAAFAEHPEVDVVYGDVLLVDENGRVIGRRRPPPFL----DKFLLYGMPICHQATFFRRSLFEKYGGFD 161

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1986027643 174 ---GLQEDYTLWIKMLATGLNVANLSDILVYARVG 205
Cdd:cd06433   162 esyRIAADYDLLLRLLLAGKIFKYLPEVLAAFRLG 196
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 4-117 1.44e-09

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 56.48  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   4 SVLMSLYikeNPQ-YLKECFESLKNQTLPATEIVVLFDGAvTTELEAIVTEY--EAILPIKAVKFPQNRGLGKTLNDGLN 80
Cdd:cd04196     1 AVLMATY---NGEkYLREQLDSILAQTYKNDELIISDDGS-TDGTVEIIKEYidKDPFIIILIRNGKNLGVARNFESLLQ 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1986027643  81 YCRHEWVFRMDTDDICVPERFEKQAKFIQQHPDVIML 117
Cdd:cd04196    77 AADGDYVFFCDQDDIWLPDKLERLLKAFLKDDKPLLV 113
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 18-178 2.37e-07

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 49.53  E-value: 2.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  18 LKECFESLKNQTLPATEIVVLFDGAV-TTELEAIVTEYEAILPIKAVKFPQNRGLGKTLNDGLNYCRHEWVFRMDTDdiC 96
Cdd:cd06423    12 IERTIESLLALDYPKLEVIVVDDGSTdDTLEILEELAALYIRRVLVVRDKENGGKAGALNAGLRHAKGDIVVVLDAD--T 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  97 VPER--FEKQAKFIQQHPDVIMLGGQIAEFGENINDIVAYRNVptsqEEIVRF---TRLRCPFNHMTV------AYKKSK 165
Cdd:cd06423    90 ILEPdaLKRLVVPFFADPKVGAVQGRVRVRNGSENLLTRLQAI----EYLSIFrlgRRAQSALGGVLVlsgafgAFRREA 165

                         170
                  ....*....|....*
gi 1986027643 166 VLECGGYQG--LQED 178
Cdd:cd06423   166 LREVGGWDEdtLTED 180
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 4-103 3.48e-06

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 47.35  E-value: 3.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   4 SVLMSLYIKENpqYLKECFESLKNQTLPATEIVVLFDGAvTTELEAIVTEYEAILPIKAVKFPQNRGLGKTLNDGLNYCR 83
Cdd:PRK10073    9 SIIIPLYNAGK--DFRAFMESLIAQTWTALEIIIVNDGS-TDNSVEIAKHYAENYPHVRLLHQANAGVSVARNTGLAVAT 85

                          90       100
                  ....*....|....*....|
gi 1986027643  84 HEWVFRMDTDDICVPERFEK 103
Cdd:PRK10073   86 GKYVAFPDADDVVYPTMYET 105
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 4-134 7.10e-06

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 46.12  E-value: 7.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   4 SVLMSLYIKENPQYLKECFESLKNQTLPATEIVVLFDGAVTTELEAIVTEYEAILPIKAVKFPQNR-GLGKTLNDGLNYC 82
Cdd:pfam10111   1 SVVIPVYNGEKTHWIQERILNQTFQYDPEFELIIINDGSTDKTLEEVSSIKDHNLQVYYPNAPDTTySLAASRNRGTSHA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1986027643  83 RHEWVFRMDTDDICVPERFEKQAKFIqqhpdvimlggQIAEFGENINDIVAY 134
Cdd:pfam10111  81 IGEYISFIDGDCLWSPDKFEKQLKIA-----------TSLALQENIQAAVVL 121
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 14-121 1.22e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 44.47  E-value: 1.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  14 NPQYLKECFESLKNQTLPATEIVVLFDGAVTTELEAIVTEYEAILPIKAvkfPQNRGLGKTLNDGLNYCRHEWVFRMDTD 93
Cdd:cd04186     8 SLEYLKACLDSLLAQTYPDFEVIVVDNASTDGSVELLRELFPEVRLIRN---GENLGFGAGNNQGIREAKGDYVLLLNPD 84

                          90       100
                  ....*....|....*....|....*...
gi 1986027643  94 DICVPERFEKQAKFIQQHPDVIMLGGQI 121
Cdd:cd04186    85 TVVEPGALLELLDAAEQDPDVGIVGPKV 112
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 4-91 2.11e-05

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 44.53  E-value: 2.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643   4 SVLMSLYIKENpqYLKECFESLKNQTLPAT--EIVVLfDGAVTTELEAIVTEYEAILP-IKAVKFPQnRGLGKTLNDGLN 80
Cdd:cd02525     3 SIIIPVRNEEK--YIEELLESLLNQSYPKDliEIIVV-DGGSTDGTREIVQEYAAKDPrIRLIDNPK-RIQSAGLNIGIR 78

                          90
                  ....*....|.
gi 1986027643  81 YCRHEWVFRMD 91
Cdd:cd02525    79 NSRGDIIIRVD 89
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 16-149 4.50e-05

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 43.60  E-value: 4.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  16 QYLKECFESLKNQTLPATEIVVLFDGAVTTELEAIVTEYEAILPIKAV-------KFPQNRGLGKTLNDGLNYCRHEWVF 88
Cdd:cd06913    10 QWLDECLESVLQQDFEGTLELSVFNDASTDKSAEIIEKWRKKLEDSGVivlvgshNSPSPKGVGYAKNQAIAQSSGRYLC 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1986027643  89 RMDTDDICVPERFEKQAKFIQQHPDVImLGGQIaefgenindivayRNVPtsQEEIVRFTR 149
Cdd:cd06913    90 FLDSDDVMMPQRIRLQYEAALQHPNSI-IGCQV-------------RRIP--EDSTERYTR 134
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 14-111 5.38e-05

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 42.95  E-value: 5.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  14 NPQYLKECFESLKNQTLPATEIVVLFDGAvTTELEAIVTEYEA--ILPIKAVKFPQNrG--LGKTLNDGLNYCRHEWVFR 89
Cdd:cd06420     8 RPEALELVLKSVLNQSILPFEVIIADDGS-TEETKELIEEFKSqfPIPIKHVWQEDE-GfrKAKIRNKAIAAAKGDYLIF 85

                          90       100
                  ....*....|....*....|..
gi 1986027643  90 MDTDdiCVPERfekqaKFIQQH 111
Cdd:cd06420    86 IDGD--CIPHP-----DFIADH 100
GT_2_like_b cd04185
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 16-116 9.74e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133028 [Multi-domain]  Cd Length: 202  Bit Score: 42.24  E-value: 9.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  16 QYLKECFESLKNQTLPATEIVVLfDGAVTTELEAIVTEYEAILPIKAVKFPQNRGLGKTLNDGLNY---CRHEWVFRMDT 92
Cdd:cd04185    10 DLLKECLDALLAQTRPPDHIIVI-DNASTDGTAEWLTSLGDLDNIVYLRLPENLGGAGGFYEGVRRayeLGYDWIWLMDD 88

                          90       100
                  ....*....|....*....|....*
gi 1986027643  93 DDICVPERFEKQ-AKFIQQHPDVIM 116
Cdd:cd04185    89 DAIPDPDALEKLlAYADKDNPQFLA 113
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 18-115 1.05e-03

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 39.58  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  18 LKECFESLKNQtlpATEIVVLFDGAvTTELEAIVTEYEAilpiKAVKFPqNRGLGKTLNDGLNYCRHEWVFRMDTDDICV 97
Cdd:cd02511    15 IERCLESVKWA---VDEIIVVDSGS-TDRTVEIAKEYGA----KVYQRW-WDGFGAQRNFALELATNDWVLSLDADERLT 85

                          90
                  ....*....|....*...
gi 1986027643  98 PERFEKQAKFIQQHPDVI 115
Cdd:cd02511    86 PELADEILALLATDDYDG 103
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 15-121 3.19e-03

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 37.93  E-value: 3.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  15 PQYLKECFESLKNQTLPATEIVVLFDGAV--TTE-LEAIVTEYEAIlpIKAVKFPQNRGLGKTLNDGLNYCRHEWVFRMD 91
Cdd:cd04188    13 PPTLEEAVEYLEERPSFSYEIIVVDDGSKdgTAEvARKLARKNPAL--IRVLTLPKNRGKGGAVRAGMLAARGDYILFAD 90

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1986027643  92 TD---DICVPERFEKQAKfiQQHPDVI-----MLGGQI 121
Cdd:cd04188    91 ADlatPFEELEKLEEALK--TSGYDIAigsraHLASAA 126
GT2_RfbF_like cd02526
RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative ...
 18-118 8.51e-03

RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative dTDP-rhamnosyl transferase. dTDP rhamnosyl transferases of Shigella flexneri add rhamnose sugars to N-acetyl-glucosamine in the O-antigen tetrasaccharide repeat. Lipopolysaccharide O antigens are important virulence determinants for many bacteria. The variations of sugar composition, the sequence of the sugars and the linkages in the O antigen provide structural diversity of the O antigen.


Pssm-ID: 133017 [Multi-domain]  Cd Length: 237  Bit Score: 36.88  E-value: 8.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1986027643  18 LKECFESLKNQTLPateiVVLFD--GAVTTELEAIVTeyeaILPIKAVKFPQNRGLGKTLNDGLNY---CRHEWVFRMDT 92
Cdd:cd02526    13 LKELLAALAEQVDK----VVVVDnsSGNDIELRLRLN----SEKIELIHLGENLGIAKALNIGIKAaleNGADYVLLFDQ 84

                          90       100
                  ....*....|....*....|....*....
gi 1986027643  93 DDICVPERFEKQAKFI---QQHPDVIMLG 118
Cdd:cd02526    85 DSVPPPDMVEKLLAYKilsDKNSNIGAVG 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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