type VI secretion system membrane subunit TssM is the IcmF (intracellular multiplication protein F) family protein that exhibits ATPase activity and energizes type VI secretion; it is a conserved T6SS inner membrane protein
IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular ...
171-222
3.26e-03
IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular multiplication and human macrophage-killing) proteins. It is found to the N-terminus of the IcmF-related domain, pfam06761.
The actual alignment was detected with superfamily member pfam14331:
Pssm-ID: 433873 [Multi-domain] Cd Length: 258 Bit Score: 40.68 E-value: 3.26e-03
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
171-1108
7.28e-67
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]
Pssm-ID: 274531 [Multi-domain] Cd Length: 1169 Bit Score: 246.48 E-value: 7.28e-67
Intracellular multiplication and human macrophage-killing; This family represents a conserved ...
410-728
6.53e-62
Intracellular multiplication and human macrophage-killing; This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed to be involved in Vibrio cholerae cell surface reorganization, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.
Pssm-ID: 429106 [Multi-domain] Cd Length: 305 Bit Score: 213.74 E-value: 6.53e-62
IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular ...
171-222
3.26e-03
IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular multiplication and human macrophage-killing) proteins. It is found to the N-terminus of the IcmF-related domain, pfam06761.
Pssm-ID: 433873 [Multi-domain] Cd Length: 258 Bit Score: 40.68 E-value: 3.26e-03
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to ...
171-1108
7.28e-67
type VI secretion protein IcmF; Members of this protein family are IcmF homologs and tend to be associated with type VI secretion systems. [Cellular processes, Pathogenesis]
Pssm-ID: 274531 [Multi-domain] Cd Length: 1169 Bit Score: 246.48 E-value: 7.28e-67
Intracellular multiplication and human macrophage-killing; This family represents a conserved ...
410-728
6.53e-62
Intracellular multiplication and human macrophage-killing; This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed to be involved in Vibrio cholerae cell surface reorganization, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins.
Pssm-ID: 429106 [Multi-domain] Cd Length: 305 Bit Score: 213.74 E-value: 6.53e-62
Type VI secretion protein IcmF C2-like domain; IcmF_C family represents a conserved region ...
986-1090
1.79e-20
Type VI secretion protein IcmF C2-like domain; IcmF_C family represents a conserved region situated towards the C-terminal end of IcmF-like proteins. It was thought to be involved in Vibrio cholerae cell surface reorganization that results in increased adherence to epithelial cells leading to an increased conjugation frequency. IcmF as a whole interacts with DotU whereby these bind tightly and form the docking area of the T6SS within the inner membrane. The exact function of this domain is not clear.
Pssm-ID: 429094 [Multi-domain] Cd Length: 106 Bit Score: 87.39 E-value: 1.79e-20
IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular ...
171-222
3.26e-03
IcmF-related N-terminal domain; This domain is found in bacterial IcmF (intracellular multiplication and human macrophage-killing) proteins. It is found to the N-terminus of the IcmF-related domain, pfam06761.
Pssm-ID: 433873 [Multi-domain] Cd Length: 258 Bit Score: 40.68 E-value: 3.26e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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