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Conserved domains on  [gi|1994015580|gb|QSB58284|]
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histidine utilization repressor [Klebsiella aerogenes]

Protein Classification

PRK14999 family protein( domain architecture ID 11487558)

PRK14999 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14999 PRK14999
histidine utilization repressor; Provisional
 1-241 7.78e-177

histidine utilization repressor; Provisional


:

Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 485.21  E-value: 7.78e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   1 MFAQQPRSAPAPFYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPK 80
Cdd:PRK14999    1 MYSSRSRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  81 GQSALFEVRSIADEIASRRHQHRCEVLLLEETEADVIQAEALNVAEGTRIFHSLMVHFENDVPVQIEDRCVNAAVVPDYL 160
Cdd:PRK14999   81 GQSALFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580 161 LQDYTATTPHDYLSLIAPLTEGEHIVEAVQATSEECALLRILPHDPCLLIRRRTWSTTHIVSHARLLFPGARYRLQGHFS 240
Cdd:PRK14999  161 TQDYRQTTPHAYLSRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQGRFI 240


                  .
gi 1994015580 241 S 241
Cdd:PRK14999  241 S 241
 
Name Accession Description Interval E-value
PRK14999 PRK14999
histidine utilization repressor; Provisional
 1-241 7.78e-177

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 485.21  E-value: 7.78e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   1 MFAQQPRSAPAPFYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPK 80
Cdd:PRK14999    1 MYSSRSRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  81 GQSALFEVRSIADEIASRRHQHRCEVLLLEETEADVIQAEALNVAEGTRIFHSLMVHFENDVPVQIEDRCVNAAVVPDYL 160
Cdd:PRK14999   81 GQSALFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580 161 LQDYTATTPHDYLSLIAPLTEGEHIVEAVQATSEECALLRILPHDPCLLIRRRTWSTTHIVSHARLLFPGARYRLQGHFS 240
Cdd:PRK14999  161 TQDYRQTTPHAYLSRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQGRFI 240


                  .
gi 1994015580 241 S 241
Cdd:PRK14999  241 S 241
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 12-241 4.38e-131

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 368.95  E-value: 4.38e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  12 PFYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPKGQSALFEVRSI 91
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  92 ADEIASRRHQHRCEVLLLEETEADVIQAEALNVAEGTRIFHSLMVHFENDVPVQIEDRCVNAAVVPDYLLQDYTATTPHD 171
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVPDYLKQDFTQTTPGA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580 172 YLSLIAPLTEGEHIVEAVQATSEECALLRILPHDPCLLIRRRTWSTTHIVSHARLLFPGARYRLQGHFSS 241
Cdd:TIGR02018 161 YLSQAAPLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWSGAQVVTRARLLYPGSRYRLVGRFTP 230
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-240 1.13e-76

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 231.29  E-value: 1.13e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   8 SAPAPFYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPKGQSALFE 87
Cdd:COG2188     1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  88 VRSIADEIASRRHQHRCEVLLLEETEADVIQAEALNVAEGTRIFHSLMVHFENDVPVQIEDRCVNAAVVPDYLLQDYTAT 167
Cdd:COG2188    81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1994015580 168 TPHDYLS--LIAPLTEGEHIVEAVQATSEECALLRILPHDPCLLIRRRTWSTT-HIVSHARLLFPGARYRLQGHFS 240
Cdd:COG2188   161 SLYELLEerYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADgRPVEYSRSYYRGDRYRFVVELR 236
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 97-234 9.98e-36

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 123.48  E-value: 9.98e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  97 SRRHQHRCEVLLLEETEADVIQAEALNVAEGTRIFHSLMVHFENDVPVQIEDRCVNAAVVPDYLLQDYTATTPHDYLS-- 174
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEer 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1994015580 175 LIAPLTEGEHIVEAVQATSEECALLRILPHDPCLLIRRRTWS-TTHIVSHARLLFPGARYR 234
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDqDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 97-234 7.11e-30

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 108.53  E-value: 7.11e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   97 SRRHQHRCEVLLLEETEADVIQAEALNVAEGTRIFHSLMVHFENDVPVQIEDRCVNAAVVPDYLLQDYTA---TTPHDYL 173
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGslyEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1994015580  174 SL-IAPLTEGEHIVEAVQATSEECALLRILPHDPCLLIRR-RTWSTTHIVSHARLLFPGARYR 234
Cdd:smart00866  81 GLkIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERvTYDDDGRPVEYSRSYYRGDRFR 143
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-77 2.54e-24

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 91.74  E-value: 2.54e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1994015580  12 PFYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVA 77
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
PRK14999 PRK14999
histidine utilization repressor; Provisional
 1-241 7.78e-177

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 485.21  E-value: 7.78e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   1 MFAQQPRSAPAPFYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPK 80
Cdd:PRK14999    1 MYSSRSRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  81 GQSALFEVRSIADEIASRRHQHRCEVLLLEETEADVIQAEALNVAEGTRIFHSLMVHFENDVPVQIEDRCVNAAVVPDYL 160
Cdd:PRK14999   81 GQSALFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580 161 LQDYTATTPHDYLSLIAPLTEGEHIVEAVQATSEECALLRILPHDPCLLIRRRTWSTTHIVSHARLLFPGARYRLQGHFS 240
Cdd:PRK14999  161 TQDYRQTTPHAYLSRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQGRFI 240


                  .
gi 1994015580 241 S 241
Cdd:PRK14999  241 S 241
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 12-241 4.38e-131

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 368.95  E-value: 4.38e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  12 PFYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPKGQSALFEVRSI 91
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  92 ADEIASRRHQHRCEVLLLEETEADVIQAEALNVAEGTRIFHSLMVHFENDVPVQIEDRCVNAAVVPDYLLQDYTATTPHD 171
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVPDYLKQDFTQTTPGA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580 172 YLSLIAPLTEGEHIVEAVQATSEECALLRILPHDPCLLIRRRTWSTTHIVSHARLLFPGARYRLQGHFSS 241
Cdd:TIGR02018 161 YLSQAAPLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWSGAQVVTRARLLYPGSRYRLVGRFTP 230
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-240 1.13e-76

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 231.29  E-value: 1.13e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   8 SAPAPFYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPKGQSALFE 87
Cdd:COG2188     1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  88 VRSIADEIASRRHQHRCEVLLLEETEADVIQAEALNVAEGTRIFHSLMVHFENDVPVQIEDRCVNAAVVPDYLLQDYTAT 167
Cdd:COG2188    81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1994015580 168 TPHDYLS--LIAPLTEGEHIVEAVQATSEECALLRILPHDPCLLIRRRTWSTT-HIVSHARLLFPGARYRLQGHFS 240
Cdd:COG2188   161 SLYELLEerYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADgRPVEYSRSYYRGDRYRFVVELR 236
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 97-234 9.98e-36

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 123.48  E-value: 9.98e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  97 SRRHQHRCEVLLLEETEADVIQAEALNVAEGTRIFHSLMVHFENDVPVQIEDRCVNAAVVPDYLLQDYTATTPHDYLS-- 174
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEer 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1994015580 175 LIAPLTEGEHIVEAVQATSEECALLRILPHDPCLLIRRRTWS-TTHIVSHARLLFPGARYR 234
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDqDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 97-234 7.11e-30

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 108.53  E-value: 7.11e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   97 SRRHQHRCEVLLLEETEADVIQAEALNVAEGTRIFHSLMVHFENDVPVQIEDRCVNAAVVPDYLLQDYTA---TTPHDYL 173
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGslyEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1994015580  174 SL-IAPLTEGEHIVEAVQATSEECALLRILPHDPCLLIRR-RTWSTTHIVSHARLLFPGARYR 234
Cdd:smart00866  81 GLkIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERvTYDDDGRPVEYSRSYYRGDRFR 143
PRK09764 PRK09764
GntR family transcriptional regulator;
12-213 1.11e-26

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 102.98  E-value: 1.11e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  12 PFYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPKGQSALFEVRSI 91
Cdd:PRK09764    5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  92 ADEIASRRHQHRCEVLLLEETEADVIQAEALNVAEGTRIFHSLMVHFENDVPVQIEDRCVNAAVVPDyLLQDYTATTPHD 171
Cdd:PRK09764   85 DEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPD-LTWQVMENSKYH 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1994015580 172 YLSLIAPLT--EGEHIVEAVQATSEECALLRILPHDPCLLIRRR 213
Cdd:PRK09764  164 FIEEVKKMVidRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSR 207
PRK11402 PRK11402
transcriptional regulator PhoB;
7-147 8.62e-25

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 97.98  E-value: 8.62e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   7 RSAPAPFYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPKGQSALF 86
Cdd:PRK11402    4 RYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALL 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1994015580  87 EVRSIADEIASRRHQHRCEVLLLEETEADVIqAEALNVAEGTRIFHSLMVHFENDVPVQIE 147
Cdd:PRK11402   84 TVSGFTDFGVSQGKATKEKVIEQERVSAAPF-CEKLNIPGNSEVFHLCRVMYLDKEPLFID 143
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 12-77 2.54e-24

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 91.74  E-value: 2.54e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1994015580  12 PFYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVA 77
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 13-76 2.34e-22

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 86.51  E-value: 2.34e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1994015580  13 FYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFV 76
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
17-76 4.19e-20

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 80.70  E-value: 4.19e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   17 VKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFV 76
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
7-98 1.59e-18

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 78.30  E-value: 1.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   7 RSAPAPFYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPKGQSALF 86
Cdd:COG1725     5 FDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEE 84

                          90
                  ....*....|..
gi 1994015580  87 EVRSIADEIASR 98
Cdd:COG1725    85 RREEFLEEALRE 96
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-85 3.92e-17

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 79.87  E-value: 3.92e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   1 MFAQQPRSAPAPFYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPK 80
Cdd:COG1167     1 MLIRLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARL 80


                  ....*
gi 1994015580  81 GQSAL 85
Cdd:COG1167    81 PAPAP 85
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
14-136 4.65e-16

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 74.58  E-value: 4.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  14 YEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPKGQSA--------- 84
Cdd:COG2186     9 AEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALldplallla 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1994015580  85 --------LFEVR-----SIADEIASRRHQHRCEVL--LLEETEADVIQAEALNVAEgtRIFHSLMV 136
Cdd:COG2186    89 lddaslrdLLEARlalepEAARLAAERATDEDLARLeaALAEMEAAADDGEAFAEAD--LAFHRAIA 153
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 8-211 7.85e-14

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 68.65  E-value: 7.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   8 SAPAPFYEKVKQAISEKIH---RGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPKGQSA 84
Cdd:PRK10079    4 SRHPTSYPTRYQEIAAKLEqelRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  85 LFEVRSIADEIASRRHQHRCEVLL--LEETEADViqAEALNVAEGTRIFHSLMVHFENDVPVqiedrCVNAAVVPDY--- 159
Cdd:PRK10079   84 LNAQARFSQNLLDQGSHPTSEKLLsvLRPASGHV--ADALGITEGENVIHLRTLRRVNGVAL-----CLIDHYFADLtww 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1994015580 160 -LLQDYTATTPHDYL--SLIAPLTEGEHIVEAVQATSEECALLRILPHDPCLLIR 211
Cdd:PRK10079  157 pTLQRFDSGSLHDFLreQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVR 211
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
3-136 1.53e-10

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 59.17  E-value: 1.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   3 AQQPRSAPAPFYEKVKQAISEKIHRGEWRPHDRIpSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPKGQ 82
Cdd:COG1802     2 TSPSPLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1994015580  83 SA--LFEVRS-----IADEIASRRHQHRCEVL--LLEETEADVIQAEALNVAEGTRIFHSLMV 136
Cdd:COG1802    81 EIreLYEVRAaleglAARLAAERATPADLARLraLLEELEAAAAAGDVAAYLELDREFHRALV 143
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
14-102 2.88e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 46.94  E-value: 2.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  14 YEKVKQ-----AISEKIHR----GEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVaepkgQSA 84
Cdd:PRK09464    3 YSKIRQpklsdVIEQQLEFlileGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFV-----QSS 77

                          90
                  ....*....|....*...
gi 1994015580  85 LFEvrSIADEIASRRHQH 102
Cdd:PRK09464   78 LWQ--SFSDPLVELLSDH 93
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 15-76 3.87e-06

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 46.68  E-value: 3.87e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1994015580  15 EKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFV 76
Cdd:PRK10421    5 DEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
PRK10225 PRK10225
Uxu operon transcriptional regulator;
7-90 6.56e-05

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 43.09  E-value: 6.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580   7 RSAPAPfYEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPKGQSALF 86
Cdd:PRK10225    5 TSAQRP-YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTD 83


                  ....
gi 1994015580  87 EVRS 90
Cdd:PRK10225   84 SPDA 87
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 14-65 3.23e-04

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 40.78  E-value: 3.23e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1994015580  14 YEKVKQAISEKIHRGEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGL 65
Cdd:PRK03837   15 SEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGL 66
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 40-91 1.30e-03

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 38.96  E-value: 1.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1994015580  40 AELVAQFGFSRMTINRALRELTDEGLLVRLQGvGTFVAEPKGQSALFEVRSI 91
Cdd:COG1349    23 EELAERLGVSEETIRRDLAELEEQGLLRRVHG-GAVLVSSAAAEPPFAERET 73
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
41-71 4.28e-03

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 34.54  E-value: 4.28e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1994015580  41 ELVAQFGFSRMTINRALRELTDEGLLVRLQG 71
Cdd:pfam08220  19 ELAELLGVSEMTIRRDLNELEEQGLLTRTHG 49
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
41-71 4.35e-03

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 34.51  E-value: 4.35e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1994015580   41 ELVAQFGFSRMTINRALRELTDEGLLVRLQG 71
Cdd:smart00420  19 ELAELLGVSEMTIRRDLNKLEEQGLLTRVHG 49
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 16-98 6.64e-03

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 37.05  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1994015580  16 KVKQAISEKIHR----GEWRPHDRIPSEAELVAQFGFSRMTINRALRELTDEGLLVRLQGVGTFVAEPKGQSA------- 84
Cdd:PRK09990    7 PIADVVAERIERlivdGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQDasplmhl 86

                          90       100
                  ....*....|....*....|....
gi 1994015580  85 ----------LFEVRSIADEIASR 98
Cdd:PRK09990   87 fssqprtlydLLEVRALLEGESAR 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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