|
Name |
Accession |
Description |
Interval |
E-value |
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
4-464 |
0e+00 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 651.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 4 KISLTTRLSLIFSAVMLTVWWLSSFILISTLNGYFDNQDRDFLTGKLQLTEEFLKTEtFRNKTDIKSLSEKINDAMVGHN 83
Cdd:TIGR01386 1 PRSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQGKLEQVRRFLRDP-ADLDEDIKRLQEKIDDLLVGHS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 84 GLFISIKNMENEKIVELYAKNSVVPAVLLNKSGDILDYMIqteENNTVYRSISRRVAVTPEQGKSKHVIITVATDTGYHT 163
Cdd:TIGR01386 80 DLALSILNPDGRLLFERAQGAALVPAVAANDALLELDQAD---AKMTHYRSILRSVAALPGGKGRKPVQITVALDINAHT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 164 LFMDKLSTWLFWFNIGLVFISVFLGWLTTRIGLKPLREMTSLASSMTVHSLDQRLNPDLAPPEISETMQEFNNMFDRLEG 243
Cdd:TIGR01386 157 HLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLED 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 244 AFRKLSDFSSDIAHELRTPVSNLMMQTQFALAKERDVSHYREILFANLEELKRLSRMTSDMLFLARSEHGLLRLDKHDVD 323
Cdd:TIGR01386 237 AFQRLSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 324 LAAELNELRELFEPLADETGKTITVEGEGVVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSG 403
Cdd:TIGR01386 317 LAAELAKVAEYFEPLAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPG 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1995778907 404 QVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSAEQQGREIVFKVRLL 464
Cdd:TIGR01386 397 IPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFILRFP 457
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
1-463 |
6.73e-80 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 255.85 E-value: 6.73e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 1 MRFKISLTTRLSLIFSAVMLTVWWLSSFILISTLNGYFDNQDRDFLTgklQLTEEFLKTETFRNKTDIKSLsEKINDAMV 80
Cdd:PRK09835 6 FQRPFSLATRLTFFISLATIAAFFAFTWIMIHSVKVHFAEQDINDLK---QISATLERVLNHPDETQARRL-MTLEDIVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 81 GHNGLFISIKNMENEKIVELYAKNSVVPAVLL------NKSGDIL-----DYMIQTEENN----TVYRSISRRVAVTPEQ 145
Cdd:PRK09835 82 GYSNVLISLADSHGKTVYHSPGAPDLREFVRDaipdkdARGGEVFlwsgpTPMMPGHGHGhmehSNWRMIALPVGPLVDG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 146 GKSKHVIITVATDtgYHTLFMDKLSTWLFwfnIGLVFIS---VFLGWLTTRIGLKPLREMTSLASSMTVHSLDQRLNPDL 222
Cdd:PRK09835 162 KPIYTLLIALSID--FHLHYINDLKNKLI---MTASVISlliVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 223 APPEISETMQEFNNMFDRLEGAFRKLSDFSSDIAHELRTPVSNLMMQTQFALAKERDVSHYREILFANLEELKRLSRMTS 302
Cdd:PRK09835 237 VPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVS 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 303 DMLFLARSEHGLLRLDKHDVDLAAELNELRELFEPLADETGKTITVEGEG-VVAGDSDMLRRAFSNLLSNAIKYSPDNTC 381
Cdd:PRK09835 317 DMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPcQVAGDPLMLRRAISNLLSNALRYTPAGEA 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 382 TAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSAEQQGREIVFKV 461
Cdd:PRK09835 397 ITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVI 476
|
..
gi 1995778907 462 RL 463
Cdd:PRK09835 477 SL 478
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
217-463 |
5.95e-59 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 196.67 E-value: 5.95e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 217 RLNPDLAPPEISETMQEFNNMFDRLEGAFRKLSDFSSDIAHELRTPVSNLMMQTQfaLAKERDVSHYREILFANLEELKR 296
Cdd:COG0642 79 LLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLE--LLLEELDEEQREYLETILRSADR 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 297 LSRMTSDMLFLARSEHGLLRLDKHDVDLAAELNELRELFEPLADETGKTITVEGEG---VVAGDSDMLRRAFSNLLSNAI 373
Cdd:COG0642 157 LLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDdlpTVRGDPDRLRQVLLNLLSNAI 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 374 KYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRFYntEGAGLGLSITRSIIHAHGGELSAE-Q 452
Cdd:COG0642 237 KYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRG--GGTGLGLAIVKRIVELHGGTIEVEsE 314
|
250
....*....|.
gi 1995778907 453 QGREIVFKVRL 463
Cdd:COG0642 315 PGKGTTFTVTL 325
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
240-463 |
2.87e-58 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 196.70 E-value: 2.87e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 240 RLEGAFRKLSDFSSDIAHELRTPVSNLMMQTQFAL-AKERDVSHYREILFANLEELKRLSRMTSDMLFLARSEHGLLRLD 318
Cdd:COG5002 157 ELERLEQMRREFVANVSHELRTPLTSIRGYLELLLdGAADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLE 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 319 KHDVDLAAELNELRELFEPLADETGKTITVEGEG---VVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNV 395
Cdd:COG5002 237 KEPVDLAELLEEVVEELRPLAEEKGIELELDLPEdplLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRI 316
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1995778907 396 MITNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSAE-QQGREIVFKVRL 463
Cdd:COG5002 317 SVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVEsEPGKGTTFTITL 385
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
233-463 |
7.83e-58 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 190.89 E-value: 7.83e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 233 EFNNMFDRLEGAFRKLSDFSSDIAHELRTPVSNLMMQTQFALAKERDVSH-YREILFANLEELKRLSRMTSDMLFLARSE 311
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEeRRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 312 HGLLRLDKHDVDLAAELNELRELFEPLADETGKTITVEGEG---VVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLER 388
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPelpLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1995778907 389 DSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRfyNTEGAGLGLSITRSIIHAHGGELSAE-QQGREIVFKVRL 463
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDNSR--GEGGTGLGLAIVKRIVEAHGGTIWVEsEPGGGTTFTVTL 234
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-464 |
9.13e-44 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 149.07 E-value: 9.13e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 361 LRRAFSNLLSNAIKYSPDNtcTAIHLER--DSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRfyNTEGAGLGLSITR 438
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPEN--TRIYITSflTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSR--NTEGAGLGLSIAK 76
|
90 100
....*....|....*....|....*.
gi 1995778907 439 SIIHAHGGELSAEQQGREIVFKVRLL 464
Cdd:cd16923 77 AIIELHGGSASAEYDDNHDLFKVRLP 102
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
240-463 |
3.68e-40 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 146.97 E-value: 3.68e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 240 RLEGAFRklsDFSSDIAHELRTPVSNL-----MMQTQFALakerDVSHYREILFANLEELKRLSRMTSDMLFLARSEHGL 314
Cdd:TIGR02966 109 RLEQMRR---DFVANVSHELRTPLTVLrgyleTLADGPDE----DPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAA 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 315 LRLDKHDVDLAAELNELRELFEPLADETGKTITVEGEGVVA--GDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDC 392
Cdd:TIGR02966 182 SPLEDEPVDMPALLDHLRDEAEALSQGKNHQITFEIDGGVDvlGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGG 261
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1995778907 393 VNVMITNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSAEQQ-GREIVFKVRL 463
Cdd:TIGR02966 262 AEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESElGKGSTFSFIF 333
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
168-451 |
1.23e-33 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 131.87 E-value: 1.23e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 168 KLSTWLFWfnIGLVFISVFLGWLTTRIGLKPLREMTSLASSMTVHSLDQRLNPDLAPpEISETMQEFNNMFDRLEGAFRK 247
Cdd:NF012163 163 KRASWLIV--ALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSND-ELGKLAQDFNQLASTLEKNEQM 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 248 LSDFSSDIAHELRTPVSNLMMQTQfalAKERDVSHY-REILFANLEELKRLSRMTSDMLFLARSEHGLLRLDKHDVDLAA 326
Cdd:NF012163 240 RRDFMADISHELRTPLAVLRAELE---AIQDGIRKFtPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVP 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 327 ----ELNELRELFEpladETGKTITVEGEG--VVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNT 400
Cdd:NF012163 317 llevEGGAFRERFA----SAGLELEVSLPDssLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVADS 392
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1995778907 401 MSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSAE 451
Cdd:NF012163 393 APGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAA 443
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
178-451 |
5.94e-31 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 124.57 E-value: 5.94e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 178 IGLVFISVFLGWLTTriglkPLREMTSLASSMTVhslDQRLN-PDLAPPEISETMQEFNNMFDRLEGafRK-LSDFSSDI 255
Cdd:PRK11100 194 IALLIGAGVVWWLNR-----SIRRLTRYADAVTE---GKPVPlPKLGSSELRELAQALESMRVKLEG--KAyVEQYVQTL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 256 AHELRTPVSNL-----MMQTQFALAKerdvshyREILFAN-LEELKRLSRMTSDMLFLARSEHGLLRLDKHDVDLAAELN 329
Cdd:PRK11100 264 THELKSPLAAIrgaaeLLQEDPPPED-------RARFTGNiLTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLE 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 330 ELRELFEPLADETGKTITVEGEGV-VAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGqVP-- 406
Cdd:PRK11100 337 ELVEAREAQAAAKGITLRLRPDDArVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPG-IPdy 415
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1995778907 407 AnLERLFDRFY---RADSSRfyntEGAGLGLSITRSIIHAHGGELSAE 451
Cdd:PRK11100 416 A-LPRIFERFYslpRPANGR----KSTGLGLAFVREVARLHGGEVTLR 458
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
179-450 |
3.14e-29 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 119.74 E-value: 3.14e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 179 GLVFISVFLG---WLTTRIGLKPLREMTSLASSMTVHSLDQRL----NPDLAPPEISetmqeFNNMFDRLEGAFRKLSDF 251
Cdd:NF040691 193 GGLALVVLLGliaWLVTRQVVAPVRSAARTAERFAAGDLSERMpvkgEDDLARLARS-----FNQMADSLQRQIRQLEEL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 252 S-------SDIAHELRTPVSNLMMQTQFaLAKERD-----VSHYREILFanlEELKRLSRMTSDMLFLARSEHGLLRLDK 319
Cdd:NF040691 268 SrlqqrfvSDVSHELRTPLTTIRMAADV-IHDSRDdfdpaTARSAELLH---TELDRFESLLSDLLEISRFDAGAAELDV 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 320 HDVDLAAELNELRELFEPLADETGKTITVEGEG---VVAGDSDMLRRAFSNLLSNAIKYSpDNTCTAIHLERDSDCVNVM 396
Cdd:NF040691 344 EPVDLRPLVRRVVDALRQLAERAGVELRVDAPGtpvVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDTAVAVT 422
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1995778907 397 ITNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSA 450
Cdd:NF040691 423 VRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEA 476
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
226-463 |
5.79e-29 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 119.12 E-value: 5.79e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 226 EISETMQEFNNMFDRLEGAFRKLSDFSSDIAHELRTPVSNLMMQTQfaLAKERdvshYREILFANLEEL--------KRL 297
Cdd:COG4251 260 ELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQ--LLEED----YGDKLDEEGREYlerirdaaERM 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 298 SRMTSDMLFLARSEHGllRLDKHDVDLAAELNELRELFEPLADETGKTITVEGEGVVAGDSDMLRRAFSNLLSNAIKYSP 377
Cdd:COG4251 334 QALIDDLLAYSRVGRQ--ELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSR 411
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 378 DNTCTAIHL--ERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRFYntEGAGLGLSITRSIIHAHGGELSAE-QQG 454
Cdd:COG4251 412 PGEPPRIEIgaEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRIWVEsEPG 489
|
....*....
gi 1995778907 455 REIVFKVRL 463
Cdd:COG4251 490 EGATFYFTL 498
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
255-463 |
4.96e-27 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 112.36 E-value: 4.96e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 255 IAHELRTPVS--NLMMQT-QFALAKE-----RDVSHYREILfanLEELKRLSRMTSDMLFLARsehgLLRLDKHDVDLAA 326
Cdd:COG5000 208 IAHEIKNPLTpiQLSAERlRRKLADKleedrEDLERALDTI---IRQVDRLKRIVDEFLDFAR----LPEPQLEPVDLNE 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 327 ELNELRELFEPLADETGKTITVE---GEGVVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSG 403
Cdd:COG5000 281 LLREVLALYEPALKEKDIRLELDldpDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPG 360
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1995778907 404 QVPANLERLFDRFYradSSRfynTEGAGLGLSITRSIIHAHGGELSAE-QQGREIVFKVRL 463
Cdd:COG5000 361 IPEEVLERIFEPFF---TTK---PKGTGLGLAIVKKIVEEHGGTIELEsRPGGGTTFTIRL 415
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
356-463 |
5.10e-26 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 101.57 E-value: 5.10e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 356 GDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRfYNTEGAGLGLS 435
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRS-RKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 1995778907 436 ITRSIIHAHGGEL---SAEQQGREIVFKVRL 463
Cdd:smart00387 80 IVKKLVELHGGEIsveSEPGGGTTFTITLPL 110
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
255-463 |
1.59e-25 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 107.19 E-value: 1.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 255 IAHELRTPVSNLMMQTQFA---LAKERDVSHYREILFANLEELKRLSRMTSDMLFLARSEhgllRLDKHDVDLAAELNEL 331
Cdd:COG4191 149 IAHEINNPLAAILGNAELLrrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRD----EEEREPVDLNELIDEA 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 332 RELFEPLADETGKTITVE---GEGVVAGDSDMLRRAFSNLLSNAI---KYSPDNTCTaIHLERDSDCVNVMITNTMSGQV 405
Cdd:COG4191 225 LELLRPRLKARGIEVELDlppDLPPVLGDPGQLEQVLLNLLINAIdamEEGEGGRIT-ISTRREGDYVVISVRDNGPGIP 303
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1995778907 406 PANLERLFDRFYradssrfynT-----EGAGLGLSITRSIIHAHGGELSAE-QQGREIVFKVRL 463
Cdd:COG4191 304 PEVLERIFEPFF---------TtkpvgKGTGLGLSISYGIVEKHGGRIEVEsEPGGGTTFTITL 358
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
175-451 |
3.37e-24 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 104.71 E-value: 3.37e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 175 WFNIGL-VFISVFLGWLTTRIGLKPLRE----MTSLA-----SSMTVHSLDqrlnpdlappEISETMQEFNNMFDRLEGA 244
Cdd:PRK10549 167 WLIVALsTLLAALATFLLARGLLAPVKRlvegTHKLAagdftTRVTPTSRD----------ELGRLAQDFNQLASTLEKN 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 245 FRKLSDFSSDIAHELRTPVSNLMMQTQfalAKERDVSHYREILFANLE-ELKRLSRMTSDMLFLARSEHGLLRLDKHDVD 323
Cdd:PRK10549 237 EQMRRDFMADISHELRTPLAVLRGELE---AIQDGVRKFTPESVASLQaEVGTLTKLVDDLHQLSLSDEGALAYRKTPVD 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 324 LAaELNEL-----RELFEpladETGKTITVE--GEGVVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVM 396
Cdd:PRK10549 314 LV-PLLEVaggafRERFA----SRGLTLQLSlpDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLT 388
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1995778907 397 ITNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSAE 451
Cdd:PRK10549 389 FADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAA 443
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
361-451 |
4.46e-24 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 96.13 E-value: 4.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 361 LRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRfyNTEGAGLGLSITRSI 440
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSR--EGGGTGLGLAIVRRI 78
|
90
....*....|.
gi 1995778907 441 IHAHGGELSAE 451
Cdd:cd00075 79 VEAHGGRITVE 89
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
182-451 |
5.35e-24 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 104.24 E-value: 5.35e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 182 FISV-FLGWLTTRIGlKPLREMTSLASSmtVHSLDQRLNPDL--APPEISETMQEFNNMFDRLE----GAFRKLSDfssd 254
Cdd:PRK09470 177 LVSTpLLLWLAWSLA-KPARKLKNAADE--VAQGNLRQHPELetGPQEFRQAGASFNQMVTALErmmtSQQRLLSD---- 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 255 IAHELRTPVSNLMMQTqfALAKERdVSHYREIlfANLE-ELKRLSRMTSDMLFLARSEHG--LLRldkhDVDLAAEL-NE 330
Cdd:PRK09470 250 ISHELRTPLTRLQLAT--ALLRRR-QGESKEL--ERIEtEAQRLDSMINDLLVLSRNQQKnhLER----ETFKANSLwSE 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 331 LRE--LFEplADETGKTITVE---GEGVVAGDSDMLRRAFSNLLSNAIKYSpdNTCTAIHLERDSDCVNVMITNTMSGQV 405
Cdd:PRK09470 321 VLEdaKFE--AEQMGKSLTVSappGPWPINGNPNALASALENIVRNALRYS--HTKIEVAFSVDKDGLTITVDDDGPGVP 396
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1995778907 406 PANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSAE 451
Cdd:PRK09470 397 EEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAE 442
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
255-463 |
1.19e-23 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 101.85 E-value: 1.19e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 255 IAHELRTPVSNLMMQTQFA---LAKERDVSHYREILfanlEELKRLSRMTSDMLFLARSEhgllRLDKHDVDLAAELNEL 331
Cdd:COG3852 142 LAHEIRNPLTGIRGAAQLLereLPDDELREYTQLII----EEADRLNNLVDRLLSFSRPR----PPEREPVNLHEVLERV 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 332 RELFEPladETGKTITVEGE-----GVVAGDSDMLRRAFSNLLSNAIKYSPDN------TCTA----IHLERDSDCVNVM 396
Cdd:COG3852 214 LELLRA---EAPKNIRIVRDydpslPEVLGDPDQLIQVLLNLVRNAAEAMPEGgtitirTRVErqvtLGGLRPRLYVRIE 290
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1995778907 397 ITNTMSGQVPANLERLFDRFYradSSRfynTEGAGLGLSITRSIIHAHGGELSAE-QQGREIVFKVRL 463
Cdd:COG3852 291 VIDNGPGIPEEILDRIFEPFF---TTK---EKGTGLGLAIVQKIVEQHGGTIEVEsEPGKGTTFRIYL 352
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
356-463 |
2.54e-22 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 91.28 E-value: 2.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 356 GDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDsDCVNVMITNTMSGQVPANLERLFDRFYRADSSrfyNTEGAGLGLS 435
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTADKR---GGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|.
gi 1995778907 436 ITRSIIHAHGGEL---SAEQQGREIVFKVRL 463
Cdd:pfam02518 77 IVRKLVELLGGTItveSEPGGGTTVTLTLPL 107
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-459 |
3.04e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 91.23 E-value: 3.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 361 LRRAFSNLLSNAIKYSPdnTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSI 440
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|..
gi 1995778907 441 IHAHGGELSAE---QQGREIVF 459
Cdd:cd16949 79 IEQHGGKIKASnrkPGGLRVRI 100
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-451 |
4.03e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 90.99 E-value: 4.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 357 DSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSI 436
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90
....*....|....*
gi 1995778907 437 TRSIIHAHGGELSAE 451
Cdd:cd16946 81 CHNIALAHGGTISAE 95
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
150-463 |
1.20e-21 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 95.83 E-value: 1.20e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 150 HVIITVATDTGYHTL-----------FMDklstWLFWFNIGLV--FISVFLGWLTTRIGLKPLREMTSLASSMTVHSLDQ 216
Cdd:NF012226 30 YFIYNYAIEVGWITLsslqedwtefhFVD----WIWLFTVILCgsVISLIIGMKLAQRFIVPINFLADAAKKISQGDLSA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 217 RLNPD-LAPPEISETMQEFNNMFDRLEGAFRKLSDFSSDIAHELRTPVSNLMMQTQFALakeRDVSHYREILFAN-LEEL 294
Cdd:NF012226 106 RAEDSqIHSAEISELMHNFNDMAQKLESSVKNAQVWNAAIAHELRTPITILQGRLQGIL---DGVFEPDPALFKSlLNQV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 295 KRLSRMTSDMLFLARSEHGLLRLDKHDVDLAAELNELRELFEPLADETGKTITVE-GEGVVAGDSDMLRRAFSNLLSNAI 373
Cdd:NF012226 183 EGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLKMFEDRLEQAQLTIVLNlTATPVFCDRRRIEQVLIALIDNAI 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 374 KYSPDNTCTaIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSAEQQ 453
Cdd:NF012226 263 RYANAGKLK-ISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEYSNS 341
|
330
....*....|
gi 1995778907 454 GREIVFKVRL 463
Cdd:NF012226 342 QGNSVFTIKL 351
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
169-449 |
1.59e-21 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 96.64 E-value: 1.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 169 LSTWLfwfnIGLVFISVFLGWLTTRiGLKPLREMTslassmtvHSLDQR-------LNPDLAPPEISETMQEFNNMFDRL 241
Cdd:PRK10337 164 LIPWL----VALPIMLIILMVLLGR-ELAPLKKLA--------LALRMRdpdsetpLNATGVPSEVRPLVEALNQLFART 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 242 EGAFRKLSDFSSDIAHELRTPVSNLMMQTQFA-LAkeRDVSHYREILFANLEE-LKRLSRMTSDMLFLARSEHGLLRLDK 319
Cdd:PRK10337 231 HAMMVRERRFTSDAAHELRSPLAALKVQTEVAqLS--DDDPQARKKALLQLHAgIDRATRLVDQLLTLSRLDSLDNLQDV 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 320 HDVDLAAELNELRELFEPLADETGKTIT--VEGEGVV-AGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSdcvnVM 396
Cdd:PRK10337 309 AEIPLEDLLQSAVMDIYHTAQQAGIDVRltLNAHPVIrTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN----FT 384
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1995778907 397 ITNTMSGQVPANLERLFDRFYRADSSrfyNTEGAGLGLSITRSIIHAHGGELS 449
Cdd:PRK10337 385 VRDNGPGVTPEALARIGERFYRPPGQ---EATGSGLGLSIVRRIAKLHGMNVS 434
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
255-447 |
2.15e-21 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 95.40 E-value: 2.15e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 255 IAHELRTPVS--NLMMQTQfALAKERDVSHYREILFANLEE-----LKRLSRMTSDMLFLARSEHGLLRLDKHDVDLA-- 325
Cdd:PRK09303 158 LAHDLRTPLTaaSLALETL-ELGQIDEDTELKPALIEQLQDqarrqLEEIERLITDLLEVGRTRWEALRFNPQKLDLGsl 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 326 -AE-LNELRELFepladeTGKTITVEGE-----GVVAGDSDMLRRAFSNLLSNAIKYSPDN---TCTAIHleRDSDCVNV 395
Cdd:PRK09303 237 cQEvILELEKRW------LAKSLEIQTDipsdlPSVYADQERIRQVLLNLLDNAIKYTPEGgtiTLSMLH--RTTQKVQV 308
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1995778907 396 MITNTMSGQVPANLERLFDRFYRADSSRfyNTEGAGLGLSITRSIIHAHGGE 447
Cdd:PRK09303 309 SICDTGPGIPEEEQERIFEDRVRLPRDE--GTEGYGIGLSVCRRIVRVHYGQ 358
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
234-452 |
2.41e-21 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 95.83 E-value: 2.41e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 234 FNNMFDRLEG--AFRK-LSDfssDIAHELRTPvsnlmmqtqfaLAKERdvshYREILFANLEE---------LKRLSRMT 301
Cdd:PRK10604 198 FNQMADNINAliASKKqLID---GIAHELRTP-----------LVRLR----YRLEMSDNLSAaesqalnrdIGQLEALI 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 302 SDMLFLARSEHGLLRLDKHDVDLAAELNELRELFEPLADETGKTITVEGEG-VVAGDSDMLRRAFSNLLSNAIKYSpdNT 380
Cdd:PRK10604 260 EELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGdYGALDMRLMERVLDNLLNNALRYA--HS 337
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1995778907 381 CTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSAEQ 452
Cdd:PRK10604 338 RVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDE 409
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
241-448 |
8.13e-21 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 94.31 E-value: 8.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 241 LEGAFRklsDFSSDIAHELRTPVSNL-----MMQTQFALAKERDVSHYreilfANLEELKRLSRMTSDMLFLARSEHGLL 315
Cdd:PRK11006 200 LEGARR---NFFANVSHELRTPLTVLqgyleMMQDQPLEGALREKALH-----TMREQTQRMEGLVKQLLTLSKIEAAPT 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 316 RLDKHDVDLAAELNELRELFEPLADETGK-TITVEGEGVVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVN 394
Cdd:PRK11006 272 IDLNEKVDVPMMLRVLEREAQTLSQGKHTiTFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAE 351
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1995778907 395 VMITNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGEL 448
Cdd:PRK11006 352 FSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRL 405
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
140-463 |
1.90e-20 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 94.42 E-value: 1.90e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 140 AVTPEQgkSKHVIITVATDTgYHTLFMDKLSTWLfwfnIGLVFISVFLGWLTTRIglkplremTSLaSSMTVHSLDQ--- 216
Cdd:TIGR03785 387 AVIAEQ--TTNGIRTLRNSA-LEKLFNVILAIMS----IGTLALFGFASWISWRI--------RRL-SDDAEAAIDSqgr 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 217 ---RLNPDLAPPEISETMQEFNNMFDRLEGAFRKLSDFSSDIAHELRTPVS-------NLMMQTQfalakERDVSHYREi 286
Cdd:TIGR03785 451 isgAIPASRSRDEIGDLSRSFAQMVARLRQYTHYLENMSSRLSHELRTPVAvvrssleNLELQAL-----EQEKQKYLE- 524
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 287 lfANLEELKRLSRMTSDMLFLARSEHGLLRLDKHDVDLAAELNELRELFEPLADETGKTITVEGEGVVA-GDSDMLRRAF 365
Cdd:TIGR03785 525 --RAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEVLSGCMQGYQMTYPPQRFELNIPETPLVMrGSPELIAQML 602
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 366 SNLLSNAIKYSPDNTCTAIHLERDSDcvNVMITNTMSG-QVPANL-ERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHA 443
Cdd:TIGR03785 603 DKLVDNAREFSPEDGLIEVGLSQNKS--HALLTVSNEGpPLPEDMgEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADF 680
|
330 340
....*....|....*....|..
gi 1995778907 444 HGGELSAE--QQGREIVFKVRL 463
Cdd:TIGR03785 681 HQGRIQAEnrQQNDGVVFRISL 702
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
179-451 |
1.15e-19 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 90.03 E-value: 1.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 179 GLVFISVFL---GWLTTRIgLKPLREMTslassmtvHSLDQRLNPDLAPPEISETMQE-------FNNMFDRLEGAFRKL 248
Cdd:PRK10755 67 SLVMVSLTLlicFQAVRWI-TRPLAELQ--------KELEARTADNLTPIAIHSSTLEieavtsaLNQLVSRLTSTLDQE 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 249 SDFSSDIAHELRTPVSNLMMQTQFaLAKerdvSHYREIlfANLeeLKRLSRMT---SDMLFLARSEHGL-------LRLd 318
Cdd:PRK10755 138 RLFTADVAHELRTPLAGIRLHLEL-LEK----QHHIDV--APL--IARLDQMMhtvEQLLQLARAGQSFssghyqtVKL- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 319 KHDVDLAAElNELRELFEpLADETGKTITVEGEGVVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMIT 398
Cdd:PRK10755 208 LEDVILPSQ-DELSEMLE-QRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVE 285
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1995778907 399 NTMSGQVPANLERLFDRFYRADsSRFyntEGAGLGLSITRSIIHAHGGELSAE 451
Cdd:PRK10755 286 DEGPGIDESKCGELSKAFVRMD-SRY---GGIGLGLSIVSRITQLHHGQFFLQ 334
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-457 |
1.28e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 83.99 E-value: 1.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 354 VAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDsDCVNVMITNTMSGQVPANLERLFDRFYRADSSrfyNTEGAGLG 433
Cdd:cd16940 7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSAD-DGAVIRVEDNGPGIDEEELEALFERFYRSDGQ---NYGGSGLG 82
|
90 100
....*....|....*....|....*..
gi 1995778907 434 LSITRSIIHAHGGEL---SAEQQGREI 457
Cdd:cd16940 83 LSIVKRIVELHGGQIflgNAQGGGLEA 109
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
229-448 |
3.03e-19 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 89.54 E-value: 3.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 229 ETMQEFNNMFDRLEGA--FRKLSDFSSDIAHELRTPVS------NLMMQTQFALAKERdvsHYREILfanLEELKRLSRM 300
Cdd:COG5806 180 ENLIENILLRKELQRAekLEVVSELAASIAHEVRNPLTvvrgfiQLLQEPELSDEKRK---QYIRIA---LEELDRAEAI 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 301 TSDMLFLARSEhgllrLDKHD-VDLAAELNELRELFEPLADETGKTITV--EGEGVVAGDSDMLRRAFSNLLSNAIKYSP 377
Cdd:COG5806 254 ITDYLTFAKPQ-----PEKLEkIDVSEELEHVIDVLSPYANMNNVEIQTelEPGLYIEGDRQKLQQCLINIIKNGIEAMP 328
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1995778907 378 DNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLfdrfyradSSRFYNT--EGAGLGLSITRSIIHAHGGEL 448
Cdd:COG5806 329 NGGTLTIDVSIDKNKVIISIKDTGVGMTKEQLERL--------GEPYFSTkeKGTGLGTMVSYRIIEAMNGTI 393
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-451 |
2.15e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 80.32 E-value: 2.15e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 361 LRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSI 440
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90
....*....|.
gi 1995778907 441 IHAHGGELSAE 451
Cdd:cd16952 81 MSRHDARLLIA 91
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
361-465 |
4.80e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 73.68 E-value: 4.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 361 LRRAFSNLLSNAIKYSPDN----TCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSS--RFYntEGAGLGL 434
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGevtlRVSLEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSttRKY--GGTGLGL 78
|
90 100 110
....*....|....*....|....*....|..
gi 1995778907 435 SITRSIIHAHGGELSAE-QQGREIVFKVRLLM 465
Cdd:cd16922 79 AISKKLVELMGGDISVEsEPGQGSTFTFTLPL 110
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
255-451 |
1.19e-15 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 79.69 E-value: 1.19e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 255 IAHELRTPVSNLMMQTQ---FALAKE-----RDVSHYRE-ILfanleelkRLSRMTSDMLFLARSEHGLLRLDKhdvdla 325
Cdd:PRK10490 671 LSHDLRTPLTVLFGQAEiltLDLASEgsphaRQASEIRQqVL--------NTTRLVNNLLDMARIQSGGFNLRK------ 736
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 326 aELNELREL-------FEPLAdeTGKTITV---EGEGVVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNV 395
Cdd:PRK10490 737 -EWLTLEEVvgsalqmLEPGL--SGHPINLslpEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQL 813
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1995778907 396 MITNTMSGqVPANLERL-FDRFYRAD--SSrfynTEGAGLGLSITRSIIHAHGGELSAE 451
Cdd:PRK10490 814 DVWDNGPG-IPPGQEQLiFDKFARGNkeSA----IPGVGLGLAICRAIVEVHGGTIWAE 867
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-448 |
2.40e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 71.72 E-value: 2.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 357 DSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFY---RADSSRfyntEGAGLG 433
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYslpRPHSGQ----KSTGLG 76
|
90
....*....|....*
gi 1995778907 434 LSITRSIIHAHGGEL 448
Cdd:cd16945 77 LAFVQEVAQLHGGRI 91
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-451 |
3.87e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 71.45 E-value: 3.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 361 LRRAFSNLLSNAIKYSPDNTC-TAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFY--RADSSRFynTEGAGLGLSIT 437
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTGrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYteRPANEAF--GQHSGLGLSIS 78
|
90
....*....|....
gi 1995778907 438 RSIIHAHGGELSAE 451
Cdd:cd16953 79 RQIIEAHGGISVAE 92
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
255-466 |
4.45e-15 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 77.70 E-value: 4.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 255 IAHELRTPVSNLMMQTQFALAKERDVSHyREILFANLEELKRLSRMTSDMLFLARSEHglLRLDKHDVDLAAElnELREL 334
Cdd:PRK11360 397 VAHEIRNPLTAIRGYVQIWRQQTSDPPS-QEYLSVVLREVDRLNKVIDQLLEFSRPRE--SQWQPVSLNALVE--EVLQL 471
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 335 FEPLADETGKTITVEGEG----VVAgDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSD-CVNVMITNTMSGQVPANL 409
Cdd:PRK11360 472 FQTAGVQARVDFETELDNelppIWA-DPELLKQVLLNILINAVQAISARGKIRIRTWQYSDgQVAVSIEDNGCGIDPELL 550
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1995778907 410 ERLFDRFYRADSSrfynteGAGLGLSITRSIIHAHGGELSAEQQ-GREIVFKVRLLMD 466
Cdd:PRK11360 551 KKIFDPFFTTKAK------GTGLGLALSQRIINAHGGDIEVESEpGVGTTFTLYLPIN 602
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
255-463 |
8.92e-15 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 75.98 E-value: 8.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 255 IAHELRTPVSNLM-MQTQFAlAKERDVSHYREILFANLEELKRLSRMTSDMLFLARSEHglLRLdkHDVDLAAELNELRE 333
Cdd:PRK10364 244 VAHEIRNPLSSIKgLAKYFA-ERAPAGGEAHQLAQVMAKEADRLNRVVSELLELVKPTH--LAL--QAVDLNDLINHSLQ 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 334 LFEplADETGKTITVE---GEGV--VAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPAN 408
Cdd:PRK10364 319 LVS--QDANSREIQLRftaNDTLpeIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQ 396
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1995778907 409 LERLFDRFYRADSsrfyntEGAGLGLSITRSIIHAHGGELSAE-QQGREIVFKVRL 463
Cdd:PRK10364 397 LEAIFTPYFTTKA------EGTGLGLAVVHNIVEQHGGTIQVAsQEGKGATFTLWL 446
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
247-451 |
1.09e-14 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 76.17 E-value: 1.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 247 KLSDFSSDIAHELRTPVSNLMMQTQ-FALAKERDVSHYREILfanLEELKRLSRMTSDMLFLARSEhgllRLDKHDVDLA 325
Cdd:COG5809 269 VVGELAAGIAHEIRNPLTSLKGFIQlLKDTIDEEQKTYLDIM---LSELDRIESIISEFLVLAKPQ----AIKYEPKDLN 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 326 AELNELRELFEPLADETGKTITVEGEGVVA---GDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLER-DSDCVNVMITNTM 401
Cdd:COG5809 342 TLIEEVIPLLQPQALLKNVQIELELEDDIPdilGDENQLKQVFINLLKNAIEAMPEGGNITIETKAeDDDKVVISVTDEG 421
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1995778907 402 SGQVPANLERLFDRFYradssrfyNT--EGAGLGLSITRSIIHAHGGELSAE 451
Cdd:COG5809 422 CGIPEERLKKLGEPFY--------TTkeKGTGLGLMVSYKIIEEHGGKITVE 465
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
255-463 |
1.91e-14 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 75.15 E-value: 1.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 255 IAHELRTPVSNL-----MMQtqfalAKERDVSHYREILfanLEELKRLSRMTSDMLFLARSEhgllRLDKHDVDLAAELN 329
Cdd:COG5805 294 IAHEIRNPLTSIkgflqLLQ-----PGIEDKEEYFDIM---LSELDRIESIISEFLALAKPQ----AVNKEKENINELIQ 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 330 ELRELFEPLADETGKTITVEGEGVVA---GDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVP 406
Cdd:COG5805 362 DVVTLLETEAILHNIQIRLELLDEDPfiyCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPE 441
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1995778907 407 ANLERLFDRFYRAdssrfyNTEGAGLGLSITRSIIHAHGGELSAEQ-QGREIVFKVRL 463
Cdd:COG5805 442 ERLKKLGEPFFTT------KEKGTGLGLMVSYKIIENHNGTIDIDSkVGKGTTFTITL 493
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-461 |
3.60e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 68.26 E-value: 3.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 357 DSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRFYNTEgAGLGLSI 436
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGH-YGMGLYI 79
|
90 100
....*....|....*....|....*...
gi 1995778907 437 TRSIIHAHGGELSAEQQ---GREIVFKV 461
Cdd:cd16975 80 AKNLVEKHGGSLIIENSqkgGAEVTVKI 107
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-463 |
3.55e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 66.00 E-value: 3.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 356 GDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLS 435
Cdd:cd16947 16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLT 95
|
90 100
....*....|....*....|....*....
gi 1995778907 436 ITRSIIHAHGGELSAEQQGRE-IVFKVRL 463
Cdd:cd16947 96 ITKRLAESMGGSIYVNSKPYEkTVFTVTL 124
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-451 |
4.81e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 65.14 E-value: 4.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 361 LRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVmiTNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSI 440
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIV--EDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90
....*....|.
gi 1995778907 441 IHAHGGELSAE 451
Cdd:cd16939 79 ALWHGGHVECD 89
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
173-449 |
8.63e-13 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 69.94 E-value: 8.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 173 LFWFNIGLVFISVFLGWLTTRIGLKPLREM--TSLASSMTVHsldqrlnPDLAPPEISETMQEFNNMFDRLEGAFRKLSD 250
Cdd:PRK09467 155 LFRYTLAIGLLSVAGGWLFIRIQNRPLVALehAALQVGKGEI-------PPPLREYGASEVRSVTRAFNQMAAGIKQLED 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 251 ----FSSDIAHELRTPVSNL-----MMQTQFALAKE---RDVSHYREILFANLEELKRLSRMTSDMLFLarseHGLLrld 318
Cdd:PRK09467 228 drtlLMAGVSHDLRTPLTRIrlateMMSEEDGYLAEsinKDIEECNAIIEQFIDYLRTGQEMPMEMADL----NALL--- 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 319 kHDVdLAAELNELRELFEPLADetgktitveGEGVVAGDSDMLRRAFSNLLSNAIKYSpdNTCTAIHLERDSDCVNVMIT 398
Cdd:PRK09467 301 -GEV-IAAESGYEREIETALQP---------GPIEVPMNPIAIKRALANLVVNAARYG--NGWIKVSSGTEGKRAWFQVE 367
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1995778907 399 NTMSGQVPANLERLFDRFYRADSSRfyNTEGAGLGLSITRSIIHAHGGELS 449
Cdd:PRK09467 368 DDGPGIPPEQLKHLFQPFTRGDSAR--GSSGTGLGLAIVKRIVDQHNGKVE 416
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-463 |
3.20e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 62.80 E-value: 3.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 367 NLLSNAIKYSPDNTCT----AIHLER-DSDCVNVMITNTMSGQVPANLERLFDRFYRADSsrfyntEGAGLGLSITRSII 441
Cdd:cd16920 7 NLVRNGIEAMSEGGCErrelTIRTSPaDDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKS------EGLGMGLSICRSII 80
|
90 100
....*....|....*....|...
gi 1995778907 442 HAHGGELSAEQQ-GREIVFKVRL 463
Cdd:cd16920 81 EAHGGRLSVESPaGGGATFQFTL 103
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-453 |
6.80e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 61.96 E-value: 6.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 361 LRRAFSNLLSNAIKYSPDNTCTAIHL--ERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRFYntEGAGLGLSITR 438
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVgaEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEY--EGTGVGLAIVR 78
|
90
....*....|....*
gi 1995778907 439 SIIHAHGGELSAEQQ 453
Cdd:cd16921 79 KIIERHGGRIWLESE 93
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
357-463 |
8.69e-12 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 61.74 E-value: 8.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 357 DSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERdSDCVNVMITNTMSGQ-VPANL-ERLFDRFYRADSSRFYNTEGAGLGL 434
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEK-FRLNRFLLTVSDSGPgIPPNLrEEIFERFRQGDGSSTRAHGGTGLGL 79
|
90 100 110
....*....|....*....|....*....|
gi 1995778907 435 SITRSIIHAHGGELS-AEQQGREIVFKVRL 463
Cdd:cd16925 80 SIVKEFVELHGGTVTvSDAPGGGALFQVEL 109
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
246-309 |
2.53e-11 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 58.76 E-value: 2.53e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1995778907 246 RKLSDFSSDIAHELRTPVSNLMMQTQFALAKERDVSHYREILFANLEELKRLSRMTSDMLFLAR 309
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
247-313 |
5.10e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 57.99 E-value: 5.10e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1995778907 247 KLSDFSSDIAHELRTPVSNLMMQTQfALAKERDVSHYREILFANLEELKRLSRMTSDMLFLARSEHG 313
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLE-LLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
249-453 |
6.73e-11 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 64.76 E-value: 6.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 249 SDFSSDIAHELRTPVSNLM----MQTQFALAKERDVshyrEILFANLEELKRLSRMTSDMLFLARSEHGLLRLDKHDVDL 324
Cdd:PRK09959 713 SQFLATMSHEIRTPISSIMgfleLLSGSGLSKEQRV----EAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDI 788
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 325 AAELNELRELFEPLADETGKTI----TVEGEGVVAGDSDMLRRAFSNLLSNAIKYSPDN----TCTAIHLERDSDCVNVM 396
Cdd:PRK09959 789 PTLVQNTCHSFGAIAASKSIALscssTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGavkiTTSLGHIDDNHAVIKMT 868
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1995778907 397 ITNTMSGQVPANLERLFDRFYRADSSRfyNTEGAGLGLSITRSIIHAHGGELSAEQQ 453
Cdd:PRK09959 869 IMDSGSGLSQEEQQQLFKRYSQTSAGR--QQTGSGLGLMICKELIKNMQGDLSLESH 923
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-448 |
9.59e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 58.61 E-value: 9.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 361 LRRAFSNLLSNAIKYSpdNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRfyNTEGAGLGLSITRSI 440
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNAR--GTSGTGLGLAIVQRI 76
|
....*...
gi 1995778907 441 IHAHGGEL 448
Cdd:cd16950 77 SDAHGGSL 84
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
247-313 |
5.50e-10 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 55.26 E-value: 5.50e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1995778907 247 KLSDFSSDIAHELRTPVSNLMMQTQFALAKERDVSHyREILFANLEELKRLSRMTSDMLFLARSEHG 313
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ-REYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
180-449 |
1.06e-08 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 57.73 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 180 LVFISVFLGWLTTRIGLKPLREMTSLASSMTVHSLDQRLnPDLAPPEISETMQEFNNMFDRL------------------ 241
Cdd:PRK15347 306 LVLLTSVLFLLLRRYLAKPLWRFVDIINKTGPAALEPRL-PENRLDELGSIAKAYNQLLDTLneqydtlenkvaertqal 384
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 242 -------EGAFRKLSDFSSDIAHELRTPVSNL-----MMQT------QFALAkerDVSHYREI-LFANLEELKRLSRMTS 302
Cdd:PRK15347 385 aeakqraEQANKRKSEHLTTISHEIRTPLNGVlgaleLLQNtpltaeQMDLA---DTARQCTLsLLAIINNLLDFSRIES 461
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 303 DMLFLARSEHGLLRLdkhdVDLAAELNELRELFEPLADETgkTITVEGEGVVAGDSDMLRRAFSNLLSNAIKYSPDNTcT 382
Cdd:PRK15347 462 GQMTLSLEETALLPL----LDQAMLTIQGPAQSKSLTLRT--FVGAHVPLYLHLDSLRLRQILVNLLGNAVKFTETGG-I 534
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1995778907 383 AIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSsrfyNTEGAGLGLSITRSIIHAHGGELS 449
Cdd:PRK15347 535 RLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELT 597
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
356-463 |
1.34e-08 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 57.29 E-value: 1.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 356 GDSDMLRRAFSNLLSNAIKYSpDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLS 435
Cdd:PRK10841 558 GDPMRLQQVISNLLSNAIKFT-DTGCIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLA 636
|
90 100
....*....|....*....|....*....
gi 1995778907 436 ITRSIIHAHGGELSAE-QQGREIVFKVRL 463
Cdd:PRK10841 637 ICEKLINMMDGDISVDsEPGMGSQFTIRI 665
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-463 |
2.74e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 51.65 E-value: 2.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 361 LRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRfyntEGAGLGLSITRSI 440
Cdd:cd16943 4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVG----EGTGLGLSLSYRI 79
|
90 100
....*....|....*....|....
gi 1995778907 441 IHAHGGELSAEQQ-GREIVFKVRL 463
Cdd:cd16943 80 IQKHGGTIRVASVpGGGTRFTIIL 103
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
170-451 |
3.81e-08 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 55.41 E-value: 3.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 170 STWLFWFNIGLVFIS-----VFLGWLTTRIGLKPLREMTSLASSMTVHSLDQrLNPDlAPPEISETMQEFNNMFDRLEGA 244
Cdd:PRK10815 185 RSYMVWSWFSYVLLAnlllvIPLLWLAAWWSLRPIEALAKQVRELEEGEREQ-LDPN-PPRELTSLVRNLNRLLKNERER 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 245 FRKLSDFSSDIAHELRTPVSnLMMQTQFAL--AKERDVSHYREILfanLEELKRLSRMTSDMLFLA--RSEHGLLRLDKH 320
Cdd:PRK10815 263 YTKYRTTLTDLTHSLKTPLA-VLQSTLRSLrsGKQMSVEQAEPIM---LEQISRISQQIGYYLHRAsmRSEHNLLSRELH 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 321 DVdlAAELNELRELFEPLADETGKTIT--VEGEGVVAGDSDMLRRAFSNLLSNAIKYspdntC---TAIHLERDSDCVNV 395
Cdd:PRK10815 339 SV--APLLDNLTSALNKVYQRKGVNITldISPEITFVGEKNDFMEVMGNVLDNACKY-----ClefVEISARQTDEHLHI 411
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1995778907 396 MITNTMSGQVPANLERLFDRFYRADSSRfyntEGAGLGLSITRSIIHAHGGELSAE 451
Cdd:PRK10815 412 VVEDDGPGIPESKRELIFDRGQRADTLR----PGQGLGLSVAREITEQYEGKISAG 463
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
242-450 |
6.98e-08 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 54.91 E-value: 6.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 242 EGAFRKLSDFSSDIAHELRTPVSNLMMQTQFaLAKERDVSHYREILFANLEELKRLSRMTSDMLFLARSEHGllrldKHD 321
Cdd:PRK11466 438 EKASQAKSAFLAAMSHEIRTPLYGILGTAQL-LADNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAG-----GKN 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 322 VDLAAELNELRELFEPL-----ADETGKTITVEGE------GVVAGDSDMLRRAFSNLLSNAIKYSpDNTCTAIHLERDS 390
Cdd:PRK11466 512 VSVSDEPFEPRPLLESTlqlmsGRVKGRPIRLATDiaddlpTALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDG 590
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 391 DCVNVMITNTMSGQVPANLERLFDRFYRADSSRfyntEGAGLGLSITRSIIHAHGGELSA 450
Cdd:PRK11466 591 EQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSA 646
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-463 |
1.45e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 49.38 E-value: 1.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 367 NLLSNAIK--YSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSrfynTEGAGLGLSITRSIIHAH 444
Cdd:cd16976 7 NLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPV----GKGTGLGLSISYGIVEEH 82
|
90 100
....*....|....*....|
gi 1995778907 445 GGELS-AEQQGREIVFKVRL 463
Cdd:cd16976 83 GGRLSvANEEGAGARFTFDL 102
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
239-449 |
2.56e-07 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 53.02 E-value: 2.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 239 DRLEGAFRKLSDFSSDIAHELRTPV------SNLMMQTQfaLAKERdVSHYREIlfanleelkRLSRMT-----SDMLFL 307
Cdd:PRK11091 274 DALEKASRDKTTFISTISHELRTPLngivglSRILLDTE--LTAEQ-RKYLKTI---------HVSAITlgnifNDIIDM 341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 308 ARSEHGLLRLDKHDVDLAAELNELRELFEPLADETGKTITVEGEG----VVAGDSDMLRRAFSNLLSNAIKYSPDNTCTa 383
Cdd:PRK11091 342 DKMERRKLQLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLEPLLplphKVITDGTRLRQILWNLISNAVKFTQQGGVT- 420
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1995778907 384 IHLERDS-DCVNVMITNTMSGQVPANLERLFDRFYRADSSRFYNTE-GAGLGLSITRSIIHAHGGELS 449
Cdd:PRK11091 421 VRVRYEEgDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPAtGTGIGLAVSKRLAQAMGGDIT 488
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
320-463 |
4.26e-07 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 51.77 E-value: 4.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 320 HDVDLAAELNELRELfeplADETGKTITVEGEGVVAG---DSDMLRRAFSNLLSNAIKYSPDNTCTA----IHLERDSDC 392
Cdd:COG3290 242 GNPVLAALLLGKAAR----ARERGIDLTIDIDSDLPDlplSDTDLVTILGNLLDNAIEAVEKLPEEErrveLSIRDDGDE 317
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1995778907 393 VNVMITNTMSGQVPANLERLFDRFYradSSRfyNTEGAGLGLSITRSIIHAHGGELS-AEQQGREIVFKVRL 463
Cdd:COG3290 318 LVIEVEDSGPGIPEELLEKIFERGF---STK--LGEGRGLGLALVKQIVEKYGGTIEvESEEGEGTVFTVRL 384
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
322-448 |
5.79e-07 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 52.00 E-value: 5.79e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 322 VDLAAELNELRELFEPLADETGKTITVEGEGVVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNtm 401
Cdd:COG4192 505 VDLRQVIEQAWELVESRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISD-- 582
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1995778907 402 SGQVPANLERLFDRFYRADSSrfynteGAGLGLSITRSIIHAHGGEL 448
Cdd:COG4192 583 NGNGWPLVDKLFTPFTTTKEV------GLGLGLSICRSIMQQFGGDL 623
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-463 |
9.10e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 47.40 E-value: 9.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 361 LRRAFSNLLSNAIKYSPDN-------TCTA----IHLERDSDCVNVMITNTMSGqVPANL-ERLFDRFYradSSRfynTE 428
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSggeiilrTRTQrqvtLGHPRHRLALRVSVIDNGPG-IPPDLqDTIFYPMV---SGR---EN 73
|
90 100 110
....*....|....*....|....*....|....*
gi 1995778907 429 GAGLGLSITRSIIHAHGGELSAEQQGREIVFKVRL 463
Cdd:cd16918 74 GTGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSL 108
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
254-451 |
1.12e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 49.62 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 254 DIAHELrtpvSNLMMQTQFAlakERDVSHYREILFANLEELKRLSRMTSDMLflARSEHGLLRLDKHDVDLAAELnelRE 333
Cdd:COG4585 64 GVGQSL----SAIKLQLEAA---RRLLDADPEAAREELEEIRELAREALAEL--RRLVRGLRPPALDDLGLAAAL---EE 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 334 LFEPLADETGKTITVEGEGVV----AGDSDMLRRAFSNLLSNAIKYSPDNTCTaIHLERDSDCVNVMITNTMSGQVPANl 409
Cdd:COG4585 132 LAERLLRAAGIRVELDVDGDPdrlpPEVELALYRIVQEALTNALKHAGATRVT-VTLEVDDGELTLTVRDDGVGFDPEA- 209
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1995778907 410 erlfdrfyradssrfynTEGAGLGLSITRSIIHAHGGELSAE 451
Cdd:COG4585 210 -----------------APGGGLGLRGMRERAEALGGTLTIG 234
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-451 |
1.95e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 46.51 E-value: 1.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 357 DSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRfYNTEGAGLGLSI 436
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYL 80
|
90
....*....|....*
gi 1995778907 437 TRSIIHAHGGELSAE 451
Cdd:cd16948 81 VKKLCDKLGHKIDVE 95
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-451 |
4.49e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 46.09 E-value: 4.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 367 NLLSNAIKYSpdNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFYRADSSRfyntEGAGLGLSITRSIIHAHGG 446
Cdd:cd16954 44 NLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQR----PGQGLGLAIAKEIVEQYGG 117
|
....*
gi 1995778907 447 ELSAE 451
Cdd:cd16954 118 ELSLS 122
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
249-463 |
4.77e-06 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 49.08 E-value: 4.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 249 SDFSSDIAHELRTPV------SNLMMQTQFAlAKERDVSHYREILFANLeelkrLSrMTSDMLFLARSEHGLLRLDKHDV 322
Cdd:PRK11107 294 SEFLANMSHELRTPLngvigfTRQTLKTPLT-PTQRDYLQTIERSANNL-----LA-IINDILDFSKLEAGKLVLENIPF 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 323 DLAAELNELRELFEPLADETGKTITVE-----GEGVVaGDSDMLRRAFSNLLSNAIKYSPD-NTCTAIHLERDSD---CV 393
Cdd:PRK11107 367 SLRETLDEVVTLLAHSAHEKGLELTLNidpdvPDNVI-GDPLRLQQIITNLVGNAIKFTESgNIDILVELRALSNtkvQL 445
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1995778907 394 NVMITNTMSGQVPANLERLFDRFYRADSS--RFYNteGAGLGLSITRSIIHAHGGEL---SAEQQGREIVFKVRL 463
Cdd:PRK11107 446 EVQIRDTGIGISERQQSQLFQAFRQADASisRRHG--GTGLGLVITQKLVNEMGGDIsfhSQPNRGSTFWFHLPL 518
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
193-246 |
4.99e-06 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 43.39 E-value: 4.99e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1995778907 193 RIGLKPLREMTSLASSMTVHSLDQRLnPDLAPPEISETMQEFNNMFDRLEGAFR 246
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRL-PVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
5-256 |
9.17e-06 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 48.09 E-value: 9.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 5 ISLTTRLSLIFSAVMLTVWWLSSFILISTLNGYFDNQDRDFLTGKLQLTEEFLKTETFRNKTDIKSLSEKINDAMVGHNG 84
Cdd:COG0840 16 LLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLLLLLAL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 85 LFISIKNMENEKIVELYAKNSVVPAVLLNKSGDILDYMIQTEENNTVYRSISRRVAVTPEQGKSKHVIITVATDTGYHTL 164
Cdd:COG0840 96 LALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 165 FMDKLSTWLFWFNIGLVFISVFLGWLTTRIGLKPLREMTSLASSMTVHSLDQRLNPDlAPPEISETMQEFNNMFDRLEGA 244
Cdd:COG0840 176 AAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVD-SKDEIGQLADAFNRMIENLREL 254
|
250
....*....|..
gi 1995778907 245 FRKLSDFSSDIA 256
Cdd:COG0840 255 VGQVRESAEQVA 266
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
240-446 |
2.70e-05 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 46.59 E-value: 2.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 240 RLEGAFR--KLSDFSSDIAHELRTPVSNLMMQTQFALAKERDVSHYREILFANLEELKRLSRMTSDMLFLARSEHGLLRl 317
Cdd:PRK13837 440 RLEHARRleAVGTLASGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRKGERNTK- 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 318 dkhDVDLAAELNELRELfepLADETGKTITVE----GEG-VVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDS-- 390
Cdd:PRK13837 519 ---PFDLSELVTEIAPL---LRVSLPPGVELDfdqdQEPaVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKlr 592
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1995778907 391 -------------DCVNVMITNTMSGQVPANLERLFDRFY--RADssrfynteGAGLGLSITRSIIHAHGG 446
Cdd:PRK13837 593 apkvlshgvlppgRYVLLRVSDTGAGIDEAVLPHIFEPFFttRAG--------GTGLGLATVHGIVSAHAG 655
|
|
| HAMP |
pfam00672 |
HAMP domain; |
190-242 |
3.61e-05 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 41.07 E-value: 3.61e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1995778907 190 LTTRIGLKPLREMTSLASSMTVHSLDQRLnPDLAPPEISETMQEFNNMFDRLE 242
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRL-PVSGRDEIGELARAFNQMAERLR 52
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
178-463 |
5.50e-05 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 45.64 E-value: 5.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 178 IGLVFISVFLGWLTTRIGLKPLREMTSLASSMTVHSLDQRLNPDlAPPEISETMQEFNNMFDRLEGAFRKLSDFSSDIAH 257
Cdd:COG3850 125 LLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVS-GRDELGTLARAFNRMADELQELYAELEEEEELEAE 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 258 ELRTPVSNLMMQTQFALAKERdvshyREILFANLEELKRLSRMTSDMLFLARSEHGLLRLDKHDVDLAAELNELRELFEP 337
Cdd:COG3850 204 LELLALLDELLLLAALLLLLA-----LLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASAL 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 338 LADETGKTITVEGEGVVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANLERLFDRFY 417
Cdd:COG3850 279 LLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAA 358
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1995778907 418 RADSSRFYNTEGAGLGLSITRSIIHAHGGELSAEQQGREIVFKVRL 463
Cdd:COG3850 359 GAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLV 404
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-453 |
1.44e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 40.98 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 357 DSDMLRRAFSNLLSNA---IKYSPDNTC-TAIHLERDSDC-VNVMITNTMSGQVPANLERLFDRfYRADSSRfynteGAG 431
Cdd:cd16944 1 DTTQISQVLTNILKNAaeaIEGRPSDVGeVRIRVEADQDGrIVLIVCDNGKGFPREMRHRATEP-YVTTRPK-----GTG 74
|
90 100
....*....|....*....|..
gi 1995778907 432 LGLSITRSIIHAHGGELSAEQQ 453
Cdd:cd16944 75 LGLAIVKKIMEEHGGRISLSNR 96
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
1-464 |
2.17e-04 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 43.95 E-value: 2.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 1 MRFKISLTTRLSLIFSAVMLTVWWLSSFILISTLNGYFDNQDRDFLTGKLQLTEEFLKTETFRNKTDIKSLSEKINDAMV 80
Cdd:COG2770 48 ALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 81 GHNGLFISIKNMENEKIVELYAKNSVVPAVLLNKSGDILDYMIQTEENNTVYRSISRRVAVTPEQGKSKHVIITVATDTG 160
Cdd:COG2770 128 LAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAA 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 161 YHTLFmdklstWLFWFNIGLVFISVFLGWLTTRIGLKPLREMTSLASSMTVHSLDQRLNPDlAPPEISETMQEFNNMFDR 240
Cdd:COG2770 208 LAALL------LLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVS-RKDEIGELARAFNRMADS 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 241 LEGAFRKLSDFSSDIAHELRTPVSNLMMQTQFALAKERDVSHYREILFANLEELKRLSRMTSDMLFLARSEHGLLRLDKH 320
Cdd:COG2770 281 LRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALL 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 321 DVDLAAELNELRE-LFEPLADETGKTITVEGEGVVAGDSDMLRRAFSNLLSNAIKYSPDNTCTAIHLERDSDCVNVMITN 399
Cdd:COG2770 361 LLLALELLLEAELlVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALEL 440
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1995778907 400 TMSGQVPANLERLFDRFYRADSSRFYNTEGAGLGLSITRSIIHAHGGELSAEQQGREIVFKVRLL 464
Cdd:COG2770 441 AAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEEL 505
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
196-241 |
2.18e-03 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 35.88 E-value: 2.18e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1995778907 196 LKPLREMTSLASSMTVHSLDQRLNPDlAPPEISETMQEFNNMFDRL 241
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVR-SKDEIGELARAFNQMAERL 45
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
363-461 |
2.30e-03 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 37.58 E-value: 2.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1995778907 363 RAFSNLLSNAI---KYSPDNTCTAIHLERDSDCVNVMITNTMSGQVPANlerlfDRFYraDSSRfyNTEGAGLGLSITRS 439
Cdd:pfam14501 8 VIFGNLLDNAIeacSKIDDNRFIRLKIREKQNFLIIRIENTYEGELKFE-----GKLP--STKT--KGDGHGIGLKSIRR 78
|
90 100
....*....|....*....|..
gi 1995778907 440 IIHAHGGELSAEQQGREIVFKV 461
Cdd:pfam14501 79 IVKKYGGNLSTEIENGIFTLSI 100
|
|
| |
