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Conserved domains on  [gi|2006709637|gb|QTA19307|]
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lytic transglycosylase domain-containing protein (plasmid) [Escherichia albertii]

Protein Classification

lytic transglycosylase domain-containing protein( domain architecture ID 12989917)

lytic transglycosylase domain-containing protein similar to phage exolysin that catalyzes the cleavage of the host peptidoglycans during virus entry

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 31-143 1.07e-46

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


:

Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 146.91  E-value: 1.07e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  31 NIDPDLLRAIAKVESGLNHLAVGKNPGRGFGIGLMQIDSQNFRHLEKFSITPEM-LFEPCLNVYVGAYFLRLAVNRLGDN 109
Cdd:cd13400     2 GVPPRLLRAIAKVESGFNPNAINRNKNGSYDIGLMQINSIWLPELARYGITREElLNDPCTNIYVGAWILARNIKRYGNT 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2006709637 110 WDAVGAYNAGFSKSRRqalrrsQYASKVRYHYRN 143
Cdd:cd13400    82 WKAVGAYNSGTPKKND------KYARKVYRIYRR 109
 
Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 31-143 1.07e-46

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 146.91  E-value: 1.07e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  31 NIDPDLLRAIAKVESGLNHLAVGKNPGRGFGIGLMQIDSQNFRHLEKFSITPEM-LFEPCLNVYVGAYFLRLAVNRLGDN 109
Cdd:cd13400     2 GVPPRLLRAIAKVESGFNPNAINRNKNGSYDIGLMQINSIWLPELARYGITREElLNDPCTNIYVGAWILARNIKRYGNT 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2006709637 110 WDAVGAYNAGFSKSRRqalrrsQYASKVRYHYRN 143
Cdd:cd13400    82 WKAVGAYNSGTPKKND------KYARKVYRIYRR 109
PRK13722 PRK13722
lytic transglycosylase; Provisional
 1-145 1.26e-41

lytic transglycosylase; Provisional


Pssm-ID: 184274 [Multi-domain]  Cd Length: 169  Bit Score: 136.36  E-value: 1.26e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637   1 MYKTTAAILLCLMISKTSTADCFEQAGQNSNIDPDLLRAIAKVESGLNHLAVGKNPGRGFGIGLMQIDSQNFRHLEKFSI 80
Cdd:PRK13722    1 MKKWMLAICLMFINEICHATDCFDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2006709637  81 TPEML-FEPCLNVYVGAYFLRLAVNRLGDNWDAVGAYNAGFSKSRRQALRRSQYASKVRYHYRNIK 145
Cdd:PRK13722   81 KPEHLtTDPCMNIYTGAYYLAIAFKKWGVSWEAVGAYNAGFRKTERQNQRRLAYASEVYRIYTGIK 146
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 23-126 1.55e-22

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 85.82  E-value: 1.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  23 FEQAGQNSNIDPDLLRAIAKVESGLNHLAVGKNpgrgFGIGLMQIDSQNFRHL-EKFSITPEMLFEPCLNVYVGAYFLRL 101
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKS----GAVGLMQIMPSTAKRLgLRVNPGVDDLFDPEKNIKAGTKYLKE 76

                          90       100
                  ....*....|....*....|....*.
gi 2006709637 102 AVNRLGDNW-DAVGAYNAGFSKSRRQ 126
Cdd:pfam01464  77 LYKQYGGDLwLALAAYNAGPGRVRKW 102
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 23-119 5.06e-15

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 69.25  E-value: 5.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  23 FEQAGQNSNIDPDLLRAIAKVESGLNHLAVGKNPGRgfgiGLMQIDSQNFRHL---EKFSITPEMLFEPCLNVYVGAYFL 99
Cdd:COG0741   107 IEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGAR----GLMQLMPATARRLglkLGLGPSPDDLFDPETNIRAGAAYL 182

                          90       100
                  ....*....|....*....|.
gi 2006709637 100 RLAVNRLGDNWD-AVGAYNAG 119
Cdd:COG0741   183 RELLDRFDGDLVlALAAYNAG 203
 
Name Accession Description Interval E-value
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 31-143 1.07e-46

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 146.91  E-value: 1.07e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  31 NIDPDLLRAIAKVESGLNHLAVGKNPGRGFGIGLMQIDSQNFRHLEKFSITPEM-LFEPCLNVYVGAYFLRLAVNRLGDN 109
Cdd:cd13400     2 GVPPRLLRAIAKVESGFNPNAINRNKNGSYDIGLMQINSIWLPELARYGITREElLNDPCTNIYVGAWILARNIKRYGNT 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2006709637 110 WDAVGAYNAGFSKSRRqalrrsQYASKVRYHYRN 143
Cdd:cd13400    82 WKAVGAYNSGTPKKND------KYARKVYRIYRR 109
PRK13722 PRK13722
lytic transglycosylase; Provisional
 1-145 1.26e-41

lytic transglycosylase; Provisional


Pssm-ID: 184274 [Multi-domain]  Cd Length: 169  Bit Score: 136.36  E-value: 1.26e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637   1 MYKTTAAILLCLMISKTSTADCFEQAGQNSNIDPDLLRAIAKVESGLNHLAVGKNPGRGFGIGLMQIDSQNFRHLEKFSI 80
Cdd:PRK13722    1 MKKWMLAICLMFINEICHATDCFDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2006709637  81 TPEML-FEPCLNVYVGAYFLRLAVNRLGDNWDAVGAYNAGFSKSRRQALRRSQYASKVRYHYRNIK 145
Cdd:PRK13722   81 KPEHLtTDPCMNIYTGAYYLAIAFKKWGVSWEAVGAYNAGFRKTERQNQRRLAYASEVYRIYTGIK 146
PRK15328 PRK15328
type III secretion system invasion protein IagB;
8-145 4.14e-36

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 121.90  E-value: 4.14e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637   8 ILLCLMISKTSTADCFEQAGQNSNIDPDLLRAIAKVESGLNHLAVGKNPGRGFGIGLMQIDSQNFRHLEKFSITP-EMLF 86
Cdd:PRK15328    7 IVIWLLSINTAWADCWLQAEKMFNIESELLYAIAQQESAMKPGAIGHNRDGSTDLGLMQINSFHMKRLKKMGISEkQLLQ 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2006709637  87 EPCLNVYVGAYFLRLAVNRLGDNWDAVGAYNAGFSKSRrqALRRSQYASKVRYHYRNIK 145
Cdd:PRK15328   87 DPCISVIVGASILSDMMKIYGYSWEAVGAYNAGTSPKR--SDIRKRYAKKIWENYRKLK 143
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 23-126 1.55e-22

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 85.82  E-value: 1.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  23 FEQAGQNSNIDPDLLRAIAKVESGLNHLAVGKNpgrgFGIGLMQIDSQNFRHL-EKFSITPEMLFEPCLNVYVGAYFLRL 101
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKS----GAVGLMQIMPSTAKRLgLRVNPGVDDLFDPEKNIKAGTKYLKE 76

                          90       100
                  ....*....|....*....|....*.
gi 2006709637 102 AVNRLGDNW-DAVGAYNAGFSKSRRQ 126
Cdd:pfam01464  77 LYKQYGGDLwLALAAYNAGPGRVRKW 102
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 23-119 5.06e-15

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 69.25  E-value: 5.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  23 FEQAGQNSNIDPDLLRAIAKVESGLNHLAVGKNPGRgfgiGLMQIDSQNFRHL---EKFSITPEMLFEPCLNVYVGAYFL 99
Cdd:COG0741   107 IEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGAR----GLMQLMPATARRLglkLGLGPSPDDLFDPETNIRAGAAYL 182

                          90       100
                  ....*....|....*....|.
gi 2006709637 100 RLAVNRLGDNWD-AVGAYNAG 119
Cdd:COG0741   183 RELLDRFDGDLVlALAAYNAG 203
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 31-119 1.22e-14

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 66.38  E-value: 1.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  31 NIDPDLLRAIAKVESGLNHLAVGKnpgRGfGIGLMQIDSQNFRHL-EKFSI---TPEMLFEPCLNVYVGAYFLRLAVNRL 106
Cdd:cd16896    16 GVDPLLVAAVIKVESNFNPNAVSS---KG-AIGLMQIMPETAEWIaEKLGLedfSEDDLYDPETNIRLGTWYLSYLLKEF 91

                          90
                  ....*....|....
gi 2006709637 107 GDNWD-AVGAYNAG 119
Cdd:cd16896    92 DGNLVlALAAYNAG 105
LT_VirB1-like cd16892
VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up ...
 31-138 2.72e-14

VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up type IV secretion systems (T4SS). T4SS are macromolecular assemblies generally composed of VirB1-11 and VirD4 proteins, and are used by bacteria to transport material across their membranes. VirB1 acts as a lytic transglycosylase (LT), and is important with respect to piercing the peptidoglycan layer in the periplasm. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381613 [Multi-domain]  Cd Length: 143  Bit Score: 65.26  E-value: 2.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  31 NIDPDLLRAIAKVESGLNHLAVGKN-------P----------------GRGFGIGLMQIDSQNFRHLekfSITPEMLFE 87
Cdd:cd16892     8 GVHPETLAAIVQVESGGNPYAIGVNggklsrqPktkaeaiatarqliaaGHNFDVGLGQINSRNLARL---GLTVEDVFD 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2006709637  88 PCLNVYVGAYFL----RLAVNRLGDNWDAVGA----YN-----AGFSKSrrqalrrsqYASKVR 138
Cdd:cd16892    85 PCTNLKAGATILtecyARAKKTGGDGQAALRAalscYNtgnftRGFSNG---------YVQKVV 139
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 34-119 7.03e-13

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 60.69  E-value: 7.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  34 PDLLRAIAKVESGLNHLAVGKNpGRgfgIGLMQIDSQNFRHLEKfsITPEMLFEPCLNVYVGAYFLRLAVNRLGDNWD-A 112
Cdd:cd00254     1 PALVLAVIRVESGFNPRAVSPA-GA---RGLMQLMPGTARDLGR--RGVDDLFDPEENIRAGARYLRELLDRFGGDLElA 74


                  ....*..
gi 2006709637 113 VGAYNAG 119
Cdd:cd00254    75 LAAYNAG 81
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 24-130 1.68e-11

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 58.34  E-value: 1.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  24 EQAGQNSNIDPDLLRAIAKVESGLNHLAVGKNPgrgfGIGLMQI-------DSQNFRHLEKFSITPEMLFEPCLNVYVGA 96
Cdd:cd16893     4 EKYAKKYGVDPALILAIIETESSFNPYAVSHSP----AYGLMQIvpstagrDVYRLLGGKGGLPSKSYLFDPENNIDIGT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2006709637  97 YFLRLAVNR-LGDNWD-------AVGAYNAG-------FSKSRRQALRR 130
Cdd:cd16893    80 AYLHILQNRyLKGIKNpksreycAIAAYNGGagnvlrtFSSDRKKAISK 128
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 23-125 1.67e-10

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 55.56  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  23 FEQAGQNSNIDPDLLRAIAKVESGLNHLAVgknpGRGFGIGLMQI----DSQNFRHLEKFSITPEMLFEPCLNVYVGAYF 98
Cdd:cd13401    10 VERAAKKNGLDPALVYAIIRQESAFDPDAV----SPAGALGLMQLmpatAKDVAKKLGLPYYSPRDLFDPEYNIRLGSAY 85

                          90       100
                  ....*....|....*....|....*...
gi 2006709637  99 LRLAVNRLGDNW-DAVGAYNAGFSKSRR 125
Cdd:cd13401    86 LAELLDRFDGNPvLALAAYNAGPGRVRR 113
PRK13864 PRK13864
type IV secretion system lytic transglycosylase VirB1; Provisional
 1-119 3.02e-10

type IV secretion system lytic transglycosylase VirB1; Provisional


Pssm-ID: 237534  Cd Length: 245  Bit Score: 56.41  E-value: 3.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637   1 MYKTT---AAILLCLMISKTSTA----DCFEQAGQN--SNIDPDLLRAIAKVESGLNHLAV----------GKNP----- 56
Cdd:PRK13864    1 MLKAAgslSIILLASMCPSSKAAplsfAEFNQLAREcaPSVAPSTLAAIAKVESRFDPLAVhdnttgetlhWQNHaqatq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  57 --------GRGFGIGLMQIDSQNFRHLekfSITPEMLFEPCLNVYVGAYFL-------------RLAVNRlgdnwdAVGA 115
Cdd:PRK13864   81 svrhrleaRHSLDVGLMQINSKNFSVL---GLTPDGALQPCTSLSAAANLLgsryaggdtadekQLALRR------AISA 151


                  ....
gi 2006709637 116 YNAG 119
Cdd:PRK13864  152 YNTG 155
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 20-68 3.94e-06

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 44.13  E-value: 3.94e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2006709637  20 ADCFEQAGQNSNIDPDLLRAIAKVESGLNHLAVGKNPG-RGFGIGLMQID 68
Cdd:cd01021    38 KDCIKQVGKKLCIDPALIAAIISRESRAGAALDKNGWGdHGNGFGLMQVD 87
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 23-143 1.12e-05

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 42.52  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  23 FEQAGQNSNIDPDLLRAIAKVESGLNHLAVGKnpgRGfGIGLMQIDSQNFRHlekFSITPemLFEPCLNVYVGAYFLRla 102
Cdd:cd13403     1 FKKYAEKYGFDWRLLAAQAYQESRFNPNARSP---AG-ARGLMQLMPSTARE---LGVND--RLDPEQNIHAGAKYLR-- 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2006709637 103 vnRLGDNWDAV-----------GAYNAGF---SKSRRQA-------------------LRRSQYASKVRYHYRN 143
Cdd:cd13403    70 --YLRDRFPPDidepdrlkfalAAYNAGPghvRDARRLAkkyglnpnvwfdnvevlplLKSPYYDPVVKYGYAR 141
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 23-130 5.39e-05

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 41.59  E-value: 5.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  23 FEQAGQNSNIDPDLLRAIAKVESGLNHLAVGKnpgRGfGIGLMQIDSQNFRHLEKFSIT-PEMlfepclNVYVGAYFLRL 101
Cdd:COG4623   268 FEKYAEEYGLDWRLLAALAYQESHWNPRARSP---TG-ARGLMQLMPATAKELGVDDRLdPEQ------SIRAGAKYLRW 337

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2006709637 102 -------AVNRLGDNWDAVGAYNAGF---SKSRRQALRR 130
Cdd:COG4623   338 lydrfpeAIDEPDRWWFALAAYNAGPghvQDARRLAKKQ 376
PHA00368 PHA00368
internal virion protein D
 16-135 2.89e-04

internal virion protein D


Pssm-ID: 222785 [Multi-domain]  Cd Length: 1315  Bit Score: 39.76  E-value: 2.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637   16 KTSTADCFEQAGQNSNIDPDLLRAIAKVESGLNHLAVGKNPGRgfgiGLMQIDSQNFRHLEKfSITPEMLFEPCLNVYVG 95
Cdd:PHA00368     8 PSEYDGLFQKAADAHGVSYDLLRKVGWDESRFNPTAKSPTGPK----GLMQFTKATAKALGL-IVDDDDRLDPELAIDAG 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2006709637   96 AYFLR-LAVNRLGDNWDAVGAYNAG---FSKSRRQALRRSQYAS 135
Cdd:PHA00368    83 ARYLAdLVGKYDGDELKAALAYNQGegrLGAPQLEAYDKGDFAS 126
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
24-101 8.60e-04

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 38.02  E-value: 8.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2006709637  24 EQAGQNSNIDPDLLRAIAKVESGLNHLAVGKNPgrgfGIGLMQIDSQN-----FRHLE-KFSITPEMLFEPCLNVYVGAY 97
Cdd:PRK15470   44 QKAGAAWGVDPQLITAIIAIESGGNPNAVSKSN----AIGLMQLKASTsgrdvYRRMGwSGEPTTSELKNPERNISMGAA 119


                  ....
gi 2006709637  98 FLRL 101
Cdd:PRK15470  120 YLNI 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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