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Conserved domains on  [gi|2023054008|gb|QTP69473|]
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helix-turn-helix transcriptional regulator [Lactococcus lactis subsp. lactis bv. diacetylactis]

Protein Classification

PadR family transcriptional regulator( domain architecture ID 10507796)

PadR family transcriptional regulator similar to Lactococcus lactis LmrR which belongs to the PadR-like family of transcriptional regulators, a transcriptional repressor of lmrCD expression and an autoregulator of its own expression.

Gene Ontology:  GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 17-90 7.47e-29

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


:

Pssm-ID: 397561  Cd Length: 74  Bit Score: 99.63  E-value: 7.47e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2023054008  17 LLNVLKQGDNYVYGIIKQVKEASNGEMELNEATLYTIFKRLEKDGIISSYWGDESQGGRRKYYRLTEIGHENMR 90
Cdd:pfam03551   1 VLAVLGEQPRYGYEIIKELEELSGGFWRPSEGTLYPILKRLEKEGLVESEWVDSGGGPPRKYYRLTDAGRRELA 74
 
Name Accession Description Interval E-value
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 17-90 7.47e-29

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 99.63  E-value: 7.47e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2023054008  17 LLNVLKQGDNYVYGIIKQVKEASNGEMELNEATLYTIFKRLEKDGIISSYWGDESQGGRRKYYRLTEIGHENMR 90
Cdd:pfam03551   1 VLAVLGEQPRYGYEIIKELEELSGGFWRPSEGTLYPILKRLEKEGLVESEWVDSGGGPPRKYYRLTDAGRRELA 74
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
4-105 5.66e-27

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 95.39  E-value: 5.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023054008   4 IPKEMLRAQTNVILLNVLKQGDNYVYGIIKQVKEASNGEMELNEATLYTIFKRLEKDGIISSYWGDESQGGRRKYYRLTE 83
Cdd:COG1695     1 MKRQLRKGTLELLILALLAEGPMYGYEIIKELEERSGGFWKVSEGTLYPALKRLEKEGLVESEWEESEGGPRRKYYRLTE 80

                          90       100
                  ....*....|....*....|..
gi 2023054008  84 IGHENMRLAFESWSRVDEIIEN 105
Cdd:COG1695    81 AGREELAEWLEEWEKLAEALEA 102
padR_acidobact TIGR03433
transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are ...
 18-103 3.07e-14

transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are putative transcriptional regulators of the PadR family, as found in species of the Acidobacteria. This family of proteins has expanded greatly in this lineage, and where it regularly is found in the vicinity of a putative transporter protein [Regulatory functions, DNA interactions]


Pssm-ID: 163261  Cd Length: 100  Bit Score: 62.96  E-value: 3.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023054008  18 LNVLKQGDNYVYGIIKQVKEASNGEMELNEATLYTIFKRLEKDGIISSYWGdESQGGRR-KYYRLTEIGHENMRLAFESW 96
Cdd:TIGR03433  10 LKTLSLGPLHGYGIAQRIQQISEDVLQVEEGSLYPALHRLERRGWIAAEWG-ESENNRRaKFYRLTAAGRKQLAAETESW 88


                  ....*..
gi 2023054008  97 SRVDEII 103
Cdd:TIGR03433  89 ARLSAAI 95
lstR PRK09416
PadR family transcriptional regulator;
6-85 5.62e-05

PadR family transcriptional regulator;


Pssm-ID: 181836  Cd Length: 135  Bit Score: 39.77  E-value: 5.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023054008   6 KEMLRAQTNV---ILLNVLK--QGDNYVYGIIKQVKEASNGEMELNEATLYTIFKRLEKDGIISSYWGDESQggrrKYYR 80
Cdd:PRK09416   31 REKIKQSSEKeedILLAILQllMNEKTGYELLQLLRQRGILTFEGNEGSLYTLLHRLEQNRFIQSSWDHEGA----KYYQ 106


                  ....*
gi 2023054008  81 LTEIG 85
Cdd:PRK09416  107 LTDKG 111
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 42-86 3.72e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 33.81  E-value: 3.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2023054008  42 EMELNEATLYTIFKRLEKDGIISSYwgdesQGGRRKYYRLTEIGH 86
Cdd:cd00090    29 RLGLSQSTVSRHLKKLEEAGLVESR-----REGRRVYYSLTDAER 68
 
Name Accession Description Interval E-value
PadR pfam03551
Transcriptional regulator PadR-like family; Members of this family are transcriptional ...
 17-90 7.47e-29

Transcriptional regulator PadR-like family; Members of this family are transcriptional regulators that appear to be related to the pfam01047 family. This family includes PadR, a protein that is involved in negative regulation of phenolic acid metabolism.


Pssm-ID: 397561  Cd Length: 74  Bit Score: 99.63  E-value: 7.47e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2023054008  17 LLNVLKQGDNYVYGIIKQVKEASNGEMELNEATLYTIFKRLEKDGIISSYWGDESQGGRRKYYRLTEIGHENMR 90
Cdd:pfam03551   1 VLAVLGEQPRYGYEIIKELEELSGGFWRPSEGTLYPILKRLEKEGLVESEWVDSGGGPPRKYYRLTDAGRRELA 74
PadR COG1695
DNA-binding transcriptional regulator, PadR family [Transcription];
4-105 5.66e-27

DNA-binding transcriptional regulator, PadR family [Transcription];


Pssm-ID: 441301  Cd Length: 102  Bit Score: 95.39  E-value: 5.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023054008   4 IPKEMLRAQTNVILLNVLKQGDNYVYGIIKQVKEASNGEMELNEATLYTIFKRLEKDGIISSYWGDESQGGRRKYYRLTE 83
Cdd:COG1695     1 MKRQLRKGTLELLILALLAEGPMYGYEIIKELEERSGGFWKVSEGTLYPALKRLEKEGLVESEWEESEGGPRRKYYRLTE 80

                          90       100
                  ....*....|....*....|..
gi 2023054008  84 IGHENMRLAFESWSRVDEIIEN 105
Cdd:COG1695    81 AGREELAEWLEEWEKLAEALEA 102
padR_acidobact TIGR03433
transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are ...
 18-103 3.07e-14

transcriptional regulator, Acidobacterial, PadR-family; Members of this protein family are putative transcriptional regulators of the PadR family, as found in species of the Acidobacteria. This family of proteins has expanded greatly in this lineage, and where it regularly is found in the vicinity of a putative transporter protein [Regulatory functions, DNA interactions]


Pssm-ID: 163261  Cd Length: 100  Bit Score: 62.96  E-value: 3.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023054008  18 LNVLKQGDNYVYGIIKQVKEASNGEMELNEATLYTIFKRLEKDGIISSYWGdESQGGRR-KYYRLTEIGHENMRLAFESW 96
Cdd:TIGR03433  10 LKTLSLGPLHGYGIAQRIQQISEDVLQVEEGSLYPALHRLERRGWIAAEWG-ESENNRRaKFYRLTAAGRKQLAAETESW 88


                  ....*..
gi 2023054008  97 SRVDEII 103
Cdd:TIGR03433  89 ARLSAAI 95
lstR PRK09416
PadR family transcriptional regulator;
6-85 5.62e-05

PadR family transcriptional regulator;


Pssm-ID: 181836  Cd Length: 135  Bit Score: 39.77  E-value: 5.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023054008   6 KEMLRAQTNV---ILLNVLK--QGDNYVYGIIKQVKEASNGEMELNEATLYTIFKRLEKDGIISSYWGDESQggrrKYYR 80
Cdd:PRK09416   31 REKIKQSSEKeedILLAILQllMNEKTGYELLQLLRQRGILTFEGNEGSLYTLLHRLEQNRFIQSSWDHEGA----KYYQ 106


                  ....*
gi 2023054008  81 LTEIG 85
Cdd:PRK09416  107 LTDKG 111
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
17-116 9.18e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 38.86  E-value: 9.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023054008  17 LLNVLKQGDNYVYGIIKqvkeasngEMELNEATLYTIFKRLEKDGIISSYWGDESQGGRRKYYRLTeigHENMRLAFeSW 96
Cdd:COG1777    22 ILALLSEEPAYVSELAR--------ELGVSRQAVYKHLRKLEEAGLVESYREGREDGRARKYYRLS---AFRLEVTL-TP 89

                          90       100
                  ....*....|....*....|
gi 2023054008  97 SRVDEIIENLEANKKDESNK 116
Cdd:COG1777    90 DLFARLARELEAYRRELSGR 109
PaaX_trns_reg TIGR02277
phenylacetic acid degradation operon negative regulatory protein PaaX; This transcriptional ...
 42-116 3.33e-04

phenylacetic acid degradation operon negative regulatory protein PaaX; This transcriptional regulator is always found in association with operons believed to be involved in the degradation of phenylacetic acid. The gene product has been shown to bind to the promoter sites and repress their transcription. [Regulatory functions, DNA interactions]


Pssm-ID: 274064 [Multi-domain]  Cd Length: 280  Bit Score: 38.26  E-value: 3.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2023054008  42 EMELNEATLYTIFKRLEKDGiissyWGDESQGGRRKYYRLTEIGHENMRLA------------FESWSRVdeIIENLEAN 109
Cdd:TIGR02277  29 GLGINERLVRTAVSRLVAQG-----WLQSERKGRRSFYSLTDKGRRRFAAAaqriydppapawDGKWRLL--LLSGPEES 101


                  ....*..
gi 2023054008 110 KKDESNK 116
Cdd:TIGR02277 102 LRDELRK 108
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 42-86 3.72e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 33.81  E-value: 3.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2023054008  42 EMELNEATLYTIFKRLEKDGIISSYwgdesQGGRRKYYRLTEIGH 86
Cdd:cd00090    29 RLGLSQSTVSRHLKKLEEAGLVESR-----REGRRVYYSLTDAER 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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