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Conserved domains on  [gi|2029776804|gb|QUF69849|]
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GspS/AspS pilotin family protein [Vibrio fluvialis]

Protein Classification

GspS/AspS pilotin family protein( domain architecture ID 11243943)

GspS/AspS pilotin family protein such as Escherichia coli pilotin AspS 2 that is part of a type II secretion system (T2SS) for the export of folded proteins across the outer membrane, and is required for correct assembly of T2SS-beta

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T2SSS_2 pfam16549
Type II secretion system (T2SS) pilotin, S protein; T2S_S is the S protein or pilotin of the ...
 26-128 4.27e-57

Type II secretion system (T2SS) pilotin, S protein; T2S_S is the S protein or pilotin of the bacterial Gram-negative secretion system in Vibrio and some E.coli and Shigella. It is given the suffix _2 to distinguish it from the PulS_OutS family of pilotins from Klebsiella and Dickeya, etc. AspS is functionally equivalent and yet structurally unrelated to the pilotins found in Klebsiella and other bacteria. AspS binds to a specific targeting sequence in the Vibrio-type secretins, enhancing the kinetics of secretin assembly; homologs of AspS are found in all species of Vibrio as well those few strains of Escherichia and Shigella that have acquired a Vibrio-type T2SS. PulS is the Kelbsiella pilotin, found in PulS_OutS, pfam09691. Not all species with a type II secretion system have this pilotin or S protein.


:

Pssm-ID: 435419  Cd Length: 104  Bit Score: 172.51  E-value: 4.27e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029776804  26 EKNLELLAANRASILSSELPLEYGPLNIMRANAKGSTIELMMVYNTDHQGAKPIDQVLKNSIHSFCNNSDVRANLDVGVG 105
Cdd:pfam16549   2 QRQLELLASNRASVLSAELPLEYGPLSIMRASAKGTTVEIMMLYNQDAKGAKPPNQVLQNSVNSYCSSKEVRANLDEGIS 81

                          90       100
                  ....*....|....*....|...
gi 2029776804 106 YRIKMRNTRGQLMVDQMVTKEDC 128
Cdd:pfam16549  82 YRIKVRNTRGQLMVDQLVTAQTC 104
 
Name Accession Description Interval E-value
T2SSS_2 pfam16549
Type II secretion system (T2SS) pilotin, S protein; T2S_S is the S protein or pilotin of the ...
 26-128 4.27e-57

Type II secretion system (T2SS) pilotin, S protein; T2S_S is the S protein or pilotin of the bacterial Gram-negative secretion system in Vibrio and some E.coli and Shigella. It is given the suffix _2 to distinguish it from the PulS_OutS family of pilotins from Klebsiella and Dickeya, etc. AspS is functionally equivalent and yet structurally unrelated to the pilotins found in Klebsiella and other bacteria. AspS binds to a specific targeting sequence in the Vibrio-type secretins, enhancing the kinetics of secretin assembly; homologs of AspS are found in all species of Vibrio as well those few strains of Escherichia and Shigella that have acquired a Vibrio-type T2SS. PulS is the Kelbsiella pilotin, found in PulS_OutS, pfam09691. Not all species with a type II secretion system have this pilotin or S protein.


Pssm-ID: 435419  Cd Length: 104  Bit Score: 172.51  E-value: 4.27e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029776804  26 EKNLELLAANRASILSSELPLEYGPLNIMRANAKGSTIELMMVYNTDHQGAKPIDQVLKNSIHSFCNNSDVRANLDVGVG 105
Cdd:pfam16549   2 QRQLELLASNRASVLSAELPLEYGPLSIMRASAKGTTVEIMMLYNQDAKGAKPPNQVLQNSVNSYCSSKEVRANLDEGIS 81

                          90       100
                  ....*....|....*....|...
gi 2029776804 106 YRIKMRNTRGQLMVDQMVTKEDC 128
Cdd:pfam16549  82 YRIKVRNTRGQLMVDQLVTAQTC 104
 
Name Accession Description Interval E-value
T2SSS_2 pfam16549
Type II secretion system (T2SS) pilotin, S protein; T2S_S is the S protein or pilotin of the ...
 26-128 4.27e-57

Type II secretion system (T2SS) pilotin, S protein; T2S_S is the S protein or pilotin of the bacterial Gram-negative secretion system in Vibrio and some E.coli and Shigella. It is given the suffix _2 to distinguish it from the PulS_OutS family of pilotins from Klebsiella and Dickeya, etc. AspS is functionally equivalent and yet structurally unrelated to the pilotins found in Klebsiella and other bacteria. AspS binds to a specific targeting sequence in the Vibrio-type secretins, enhancing the kinetics of secretin assembly; homologs of AspS are found in all species of Vibrio as well those few strains of Escherichia and Shigella that have acquired a Vibrio-type T2SS. PulS is the Kelbsiella pilotin, found in PulS_OutS, pfam09691. Not all species with a type II secretion system have this pilotin or S protein.


Pssm-ID: 435419  Cd Length: 104  Bit Score: 172.51  E-value: 4.27e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029776804  26 EKNLELLAANRASILSSELPLEYGPLNIMRANAKGSTIELMMVYNTDHQGAKPIDQVLKNSIHSFCNNSDVRANLDVGVG 105
Cdd:pfam16549   2 QRQLELLASNRASVLSAELPLEYGPLSIMRASAKGTTVEIMMLYNQDAKGAKPPNQVLQNSVNSYCSSKEVRANLDEGIS 81

                          90       100
                  ....*....|....*....|...
gi 2029776804 106 YRIKMRNTRGQLMVDQMVTKEDC 128
Cdd:pfam16549  82 YRIKVRNTRGQLMVDQLVTAQTC 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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