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Conserved domains on  [gi|2029975795|gb|QUG98821|]
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pur operon repressor [Bacillus tropicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
purR_Bsub super family cl31138
pur operon repressor, Bacillus subtilis type; This model represents the puring operon ...
 4-269 2.00e-137

pur operon repressor, Bacillus subtilis type; This model represents the puring operon repressor PurR of low-GC Gram-positive bacteria. This homodimeric repressor contains a large region homologous to phosphoribosyltransferases and is inhibited by 5-phosphoribosyl 1-pyrophosphate. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis, Regulatory functions, DNA interactions]


The actual alignment was detected with superfamily member TIGR01743:

Pssm-ID: 130804 [Multi-domain]  Cd Length: 268  Bit Score: 388.37  E-value: 2.00e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795   4 RRSTRLVDMTYYLLQNPRQLVSLTFFAERYQSAKSSISEDLVIIKQTFEQQGVGTLQTIPGAAGGVKYIPYISEEEADLI 83
Cdd:TIGR01743   2 RRSGRLVDLTNYLITNPNKLIPLNFFSERYESAKSSISEDIVIIKETFEKFGIGKLLTVPGAAGGVKYIPKMSQAEAEEF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795  84 IGELCSLFENPDRILPGGYLYMTDLLSNPRHINGAGRLFASVFARQPIDAVMTVATKGIPLAYAVANYLDVPVVIARKDN 163
Cdd:TIGR01743  82 VEELCQSLSEPERILPGGYLYLTDILGKPSILSKIGKILASVFAEREIDAVMTVATKGIPLAYAVASVLNVPLVIVRKDS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 164 KVTEGPTVSINYVSGSSKRIQTMTLAKRSLPEGSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVESTDIEERLI 243
Cdd:TIGR01743 162 KVTEGSTVSINYVSGSSNRIQTMSLAKRSLKTGSKVLIIDDFMKAGGTINGMINLLDEFDAEVAGIGVLIDNEGVDEKLV 241

                         250       260
                  ....*....|....*....|....*.
gi 2029975795 244 NNFVSLIRLSEVDVKEKAIQVEKGNY 269
Cdd:TIGR01743 242 DDYMSLLTLSNINEKEKSIEIENGNF 267
 
Name Accession Description Interval E-value
purR_Bsub TIGR01743
pur operon repressor, Bacillus subtilis type; This model represents the puring operon ...
 4-269 2.00e-137

pur operon repressor, Bacillus subtilis type; This model represents the puring operon repressor PurR of low-GC Gram-positive bacteria. This homodimeric repressor contains a large region homologous to phosphoribosyltransferases and is inhibited by 5-phosphoribosyl 1-pyrophosphate. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis, Regulatory functions, DNA interactions]


Pssm-ID: 130804 [Multi-domain]  Cd Length: 268  Bit Score: 388.37  E-value: 2.00e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795   4 RRSTRLVDMTYYLLQNPRQLVSLTFFAERYQSAKSSISEDLVIIKQTFEQQGVGTLQTIPGAAGGVKYIPYISEEEADLI 83
Cdd:TIGR01743   2 RRSGRLVDLTNYLITNPNKLIPLNFFSERYESAKSSISEDIVIIKETFEKFGIGKLLTVPGAAGGVKYIPKMSQAEAEEF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795  84 IGELCSLFENPDRILPGGYLYMTDLLSNPRHINGAGRLFASVFARQPIDAVMTVATKGIPLAYAVANYLDVPVVIARKDN 163
Cdd:TIGR01743  82 VEELCQSLSEPERILPGGYLYLTDILGKPSILSKIGKILASVFAEREIDAVMTVATKGIPLAYAVASVLNVPLVIVRKDS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 164 KVTEGPTVSINYVSGSSKRIQTMTLAKRSLPEGSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVESTDIEERLI 243
Cdd:TIGR01743 162 KVTEGSTVSINYVSGSSNRIQTMSLAKRSLKTGSKVLIIDDFMKAGGTINGMINLLDEFDAEVAGIGVLIDNEGVDEKLV 241

                         250       260
                  ....*....|....*....|....*.
gi 2029975795 244 NNFVSLIRLSEVDVKEKAIQVEKGNY 269
Cdd:TIGR01743 242 DDYMSLLTLSNINEKEKSIEIENGNF 267
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 86-252 2.21e-55

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 176.42  E-value: 2.21e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795  86 ELCSLFENPDRILPGG--YLYMTDLLSNPRHINGAGRLFASVFARQPIDAVMTVATKGIPLAYAVANYLDVPVVIARKDN 163
Cdd:COG0503     2 DLKDLIRDIPDFPKPGilFRDITPLLGDPELFRAAGDELAERFADKGIDKVVGIEARGFILAAALAYALGVPFVPARKPG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 164 KVTeGPTVSINYVSGSSKRiQTMTLAKRSLPEGSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVESTDIE--ER 241
Cdd:COG0503    82 KLP-GETVSEEYDLEYGTG-DTLELHKDALKPGDRVLIVDDLLATGGTAKAAIKLVEEAGAEVVGIAFLIELGFLGgrEK 159

                         170
                  ....*....|..
gi 2029975795 242 LIN-NFVSLIRL 252
Cdd:COG0503   160 LRDyPVESLLTL 171
PuR_N pfam09182
Bacterial purine repressor, N-terminal; The N-terminal domain of the bacterial purine ...
 4-73 1.32e-42

Bacterial purine repressor, N-terminal; The N-terminal domain of the bacterial purine repressor PuR is a winged-helix domain, a subdivision of the HTH structural family. It consists of a canonical arrangement of secondary structures: a1-b1-a2-T-a3-b2-W-b3, where a2-T-a3 is the HTH motif, a3 is the recognition helix, and W is the wing. The domain allows for recognition of a conserved CGAA sequence in the centre of a DNA PurBox, resulting in binding to the major groove of DNA.


Pssm-ID: 430456  Cd Length: 70  Bit Score: 140.28  E-value: 1.32e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795   4 RRSTRLVDMTYYLLQNPRQLVSLTFFAERYQSAKSSISEDLVIIKQTFEQQGVGTLQTIPGAAGGVKYIP 73
Cdd:pfam09182   1 KRSERLVAITKILLENPNKLISLTYFAERFGAAKSSISEDLVIIKEAFEKEGLGTIETIPGAAGGVKYIP 70
PRK09219 PRK09219
xanthine phosphoribosyltransferase; Validated
 119-234 6.48e-21

xanthine phosphoribosyltransferase; Validated


Pssm-ID: 181705  Cd Length: 189  Bit Score: 87.53  E-value: 6.48e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 119 GRLFASVFARQPIDAVMTVATKGIPLAYAVANYLDVPVVIARKDNKVT-EGPTVSINYVSGSSKRIQTMTLAKRSLPEGS 197
Cdd:PRK09219   39 GKEFARRFKDEGITKILTIEASGIAPAVMAALALGVPVVFAKKKKSLTlTDDVYTATVYSFTKQVTSTVSVSKKFLSEGD 118

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2029975795 198 NVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVE 234
Cdd:PRK09219  119 RVLIIDDFLANGQAALGLIDIIEQAGAKVAGIGIVIE 155
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 118-234 9.46e-15

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 69.35  E-value: 9.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 118 AGRLFASVFARQP--IDAVMTVATKGIPLAYAVANYLDVPVVIARKDNKvtegptvsinYVSGSSKRIQTMTLAKRSLPE 195
Cdd:cd06223     1 AGRLLAEEIREDLlePDVVVGILRGGLPLAAALARALGLPLAFIRKERK----------GPGRTPSEPYGLELPLGGDVK 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2029975795 196 GSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVE 234
Cdd:cd06223    71 GKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLD 109
 
Name Accession Description Interval E-value
purR_Bsub TIGR01743
pur operon repressor, Bacillus subtilis type; This model represents the puring operon ...
 4-269 2.00e-137

pur operon repressor, Bacillus subtilis type; This model represents the puring operon repressor PurR of low-GC Gram-positive bacteria. This homodimeric repressor contains a large region homologous to phosphoribosyltransferases and is inhibited by 5-phosphoribosyl 1-pyrophosphate. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis, Regulatory functions, DNA interactions]


Pssm-ID: 130804 [Multi-domain]  Cd Length: 268  Bit Score: 388.37  E-value: 2.00e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795   4 RRSTRLVDMTYYLLQNPRQLVSLTFFAERYQSAKSSISEDLVIIKQTFEQQGVGTLQTIPGAAGGVKYIPYISEEEADLI 83
Cdd:TIGR01743   2 RRSGRLVDLTNYLITNPNKLIPLNFFSERYESAKSSISEDIVIIKETFEKFGIGKLLTVPGAAGGVKYIPKMSQAEAEEF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795  84 IGELCSLFENPDRILPGGYLYMTDLLSNPRHINGAGRLFASVFARQPIDAVMTVATKGIPLAYAVANYLDVPVVIARKDN 163
Cdd:TIGR01743  82 VEELCQSLSEPERILPGGYLYLTDILGKPSILSKIGKILASVFAEREIDAVMTVATKGIPLAYAVASVLNVPLVIVRKDS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 164 KVTEGPTVSINYVSGSSKRIQTMTLAKRSLPEGSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVESTDIEERLI 243
Cdd:TIGR01743 162 KVTEGSTVSINYVSGSSNRIQTMSLAKRSLKTGSKVLIIDDFMKAGGTINGMINLLDEFDAEVAGIGVLIDNEGVDEKLV 241

                         250       260
                  ....*....|....*....|....*.
gi 2029975795 244 NNFVSLIRLSEVDVKEKAIQVEKGNY 269
Cdd:TIGR01743 242 DDYMSLLTLSNINEKEKSIEIENGNF 267
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 86-252 2.21e-55

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 176.42  E-value: 2.21e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795  86 ELCSLFENPDRILPGG--YLYMTDLLSNPRHINGAGRLFASVFARQPIDAVMTVATKGIPLAYAVANYLDVPVVIARKDN 163
Cdd:COG0503     2 DLKDLIRDIPDFPKPGilFRDITPLLGDPELFRAAGDELAERFADKGIDKVVGIEARGFILAAALAYALGVPFVPARKPG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 164 KVTeGPTVSINYVSGSSKRiQTMTLAKRSLPEGSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVESTDIE--ER 241
Cdd:COG0503    82 KLP-GETVSEEYDLEYGTG-DTLELHKDALKPGDRVLIVDDLLATGGTAKAAIKLVEEAGAEVVGIAFLIELGFLGgrEK 159

                         170
                  ....*....|..
gi 2029975795 242 LIN-NFVSLIRL 252
Cdd:COG0503   160 LRDyPVESLLTL 171
PuR_N pfam09182
Bacterial purine repressor, N-terminal; The N-terminal domain of the bacterial purine ...
 4-73 1.32e-42

Bacterial purine repressor, N-terminal; The N-terminal domain of the bacterial purine repressor PuR is a winged-helix domain, a subdivision of the HTH structural family. It consists of a canonical arrangement of secondary structures: a1-b1-a2-T-a3-b2-W-b3, where a2-T-a3 is the HTH motif, a3 is the recognition helix, and W is the wing. The domain allows for recognition of a conserved CGAA sequence in the centre of a DNA PurBox, resulting in binding to the major groove of DNA.


Pssm-ID: 430456  Cd Length: 70  Bit Score: 140.28  E-value: 1.32e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795   4 RRSTRLVDMTYYLLQNPRQLVSLTFFAERYQSAKSSISEDLVIIKQTFEQQGVGTLQTIPGAAGGVKYIP 73
Cdd:pfam09182   1 KRSERLVAITKILLENPNKLISLTYFAERFGAAKSSISEDLVIIKEAFEKEGLGTIETIPGAAGGVKYIP 70
PRK09219 PRK09219
xanthine phosphoribosyltransferase; Validated
 119-234 6.48e-21

xanthine phosphoribosyltransferase; Validated


Pssm-ID: 181705  Cd Length: 189  Bit Score: 87.53  E-value: 6.48e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 119 GRLFASVFARQPIDAVMTVATKGIPLAYAVANYLDVPVVIARKDNKVT-EGPTVSINYVSGSSKRIQTMTLAKRSLPEGS 197
Cdd:PRK09219   39 GKEFARRFKDEGITKILTIEASGIAPAVMAALALGVPVVFAKKKKSLTlTDDVYTATVYSFTKQVTSTVSVSKKFLSEGD 118

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2029975795 198 NVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVE 234
Cdd:PRK09219  119 RVLIIDDFLANGQAALGLIDIIEQAGAKVAGIGIVIE 155
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 108-255 4.15e-18

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 80.20  E-value: 4.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 108 LLSNPRHINGAGRLFASVFARQ--PIDAVMTVATKGIPLAYAVANYLDVPVVIARKDNKvTEGptvsinyvsgsskriqT 185
Cdd:COG0461    39 VLSYPEALELLGEALAELIKELgpEFDAVAGPATGGIPLAAAVARALGLPAIFVRKEAK-DHG----------------T 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2029975795 186 MTLAKRSLPEGSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVE-STDIEERLINN---FVSLIRLSEV 255
Cdd:COG0461   102 GGQIEGGLLPGERVLVVEDVITTGGSVLEAVEALREAGAEVVGVAVIVDrEEGAAENLEEAgvpLHSLLTLDDL 175
XPRTase TIGR01744
xanthine phosphoribosyltransferase; This model represent a xanthine-specific ...
 96-234 1.74e-17

xanthine phosphoribosyltransferase; This model represent a xanthine-specific phosphoribosyltransferase of Bacillus subtilis and closely related proteins from other species, mostly from other Gram-positive bacteria. The adjacent gene is a xanthine transporter; B. subtilis can import xanthine for the purine salvage pathway or for catabolism to obtain nitrogen. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 130805  Cd Length: 191  Bit Score: 78.31  E-value: 1.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795  96 RILPGGYLYMTDLLS---NPRHINGAGRLFASVFARQPIDAVMTVATKGIPLAYAVANYLDVPVVIARKDNKVTEGPTV- 171
Cdd:TIGR01744  13 VVLPGGILKVDSFLNhqiDPKLMQEVGEEFARRFADDGITKIVTIEASGIAPAIMTGLKLGVPVVFARKKKPLTLTDNLl 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2029975795 172 SINYVSGSSKRIQTMTLAKRSLPEGSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVE 234
Cdd:TIGR01744  93 TASVHSFTKQTTSTVAVSGEFLSDQDRVLIIDDFLANGQAAHGLVDIAKQAGAKIAGIGIVIE 155
PRK08558 PRK08558
adenine phosphoribosyltransferase; Provisional
 123-233 7.04e-17

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 181466 [Multi-domain]  Cd Length: 238  Bit Score: 77.72  E-value: 7.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 123 ASVFARQPIDAVMTVATKGIPLAYAVANYLDVPVVIARKdNKVTEGPTVSINYVSGSSKRIQTMTLAKRSLPEGSNVLII 202
Cdd:PRK08558  104 AERFMGLRVDVVLTAATDGIPLAVAIASYFGADLVYAKK-SKETGVEKFYEEYQRLASGIEVTLYLPASALKKGDRVLIV 182

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2029975795 203 DDFMKAGGTIQGMMSMLEEFKANLVGIGVLV 233
Cdd:PRK08558  183 DDIIRSGETQRALLDLARQAGADVVGVFFLI 213
PRK02304 PRK02304
adenine phosphoribosyltransferase; Provisional
 100-242 7.46e-17

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 235028  Cd Length: 175  Bit Score: 76.27  E-value: 7.46e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 100 GGYLY--MTDLLSNPRHINGAGRLFASVFARQPIDAVMTVATKGIPLAYAVANYLDVPVVIARKDNKVtEGPTVSINYVS 177
Cdd:PRK02304   19 PGILFrdITPLLADPEAFREVIDALVERYKDADIDKIVGIEARGFIFGAALAYKLGIGFVPVRKPGKL-PRETISESYEL 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2029975795 178 GSSKriQTMTLAKRSLPEGSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVESTDI--EERL 242
Cdd:PRK02304   98 EYGT--DTLEIHKDAIKPGDRVLIVDDLLATGGTLEAAIKLLERLGAEVVGAAFVIELPDLggREKL 162
pyrE PRK00455
orotate phosphoribosyltransferase; Validated
 102-255 6.18e-16

orotate phosphoribosyltransferase; Validated


Pssm-ID: 234771  Cd Length: 202  Bit Score: 74.42  E-value: 6.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 102 YLYMTDLLSNPRHINGAGRLFASVFARQ--PIDAVMTVATKGIPLAYAVANYLDVPVVIARKDNKV--TEGptvsinyvs 177
Cdd:PRK00455   34 YFDCRKLLSYPEALALLGRFLAEAIKDSgiEFDVVAGPATGGIPLAAAVARALDLPAIFVRKEAKDhgEGG--------- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 178 gsskriqTMTLAkrsLPEGSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVE-STDIEERLINN---FVSLIRLS 253
Cdd:PRK00455  105 -------QIEGR---RLFGKRVLVVEDVITTGGSVLEAVEAIRAAGAEVVGVAVIVDrQSAAQEVFADAgvpLISLITLD 174


                  ..
gi 2029975795 254 EV 255
Cdd:PRK00455  175 DL 176
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 106-234 3.38e-15

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 71.24  E-value: 3.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 106 TDLLSNPRHINGAGRLFASVF--ARQPIDAVMTVATKGIPLAYAVANYLDVPVVIARKDNKVTEGPTVSInyvsgsskri 183
Cdd:pfam00156   3 DEILDNPAILKAVARLAAQINedYGGKPDVVVGILRGGLPFAGILARRLDVPLAFVRKVSYNPDTSEVMK---------- 72

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2029975795 184 qtmTLAKRSLPEGSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVE 234
Cdd:pfam00156  73 ---TSSALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLID 120
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 118-234 9.46e-15

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 69.35  E-value: 9.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 118 AGRLFASVFARQP--IDAVMTVATKGIPLAYAVANYLDVPVVIARKDNKvtegptvsinYVSGSSKRIQTMTLAKRSLPE 195
Cdd:cd06223     1 AGRLLAEEIREDLlePDVVVGILRGGLPLAAALARALGLPLAFIRKERK----------GPGRTPSEPYGLELPLGGDVK 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2029975795 196 GSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVE 234
Cdd:cd06223    71 GKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLD 109
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 96-240 1.33e-10

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 58.84  E-value: 1.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795  96 RILPGGYLYMTDLLSNPRHINGAGRLFAsvfARQP--IDAVMTVATKGIPLAYAVANYLDVPVVIARKDNKVTEGPTVSI 173
Cdd:PRK07322   19 RVGPDLAIALFVILGDTELTEAAAEALA---KRLPteVDVLVTPETKGIPLAHALSRRLGKPYVVARKSRKPYMQDPIIQ 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 174 NYVSGSSKRIQTMTLAKRSLP--EGSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVG-IGVLVESTDIEE 240
Cdd:PRK07322   96 EVVSITTGKPQLLVLDGADAEklKGKRVAIVDDVVSTGGTLTALERLVERAGGQVVAkAAIFAEGDASNR 165
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 131-256 5.24e-07

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 49.10  E-value: 5.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 131 IDAVMTVATKGIPLAYAVANYLDV------PVVIARKDNKVTEGpTVSINYVSgsskriqtmtlakrslPEGSNVLIIDD 204
Cdd:PRK02277   86 VDVVVGIAKSGVPLATLVADELGKdlaiyhPKKWDHGEGEKKTG-SFSRNFAS----------------VEGKRCVIVDD 148

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2029975795 205 FMKAGGTIQGMMSMLEEFKANLVGIGVLVESTDIEErlINN--FVSLIRLSEVD 256
Cdd:PRK02277  149 VITSGTTMKETIEYLKEHGGKPVAVVVLIDKSGIDE--IDGvpVYSLIRVVRVD 200
PRK12560 PRK12560
adenine phosphoribosyltransferase; Provisional
 131-241 3.75e-06

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 183595  Cd Length: 187  Bit Score: 46.32  E-value: 3.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 131 IDAVMTVATKGIPLAYAVANYLDVPVVIARKDNKVTEgpTVSINYVSGSSKRIQTmTLAKRSLPEGSNVLIIDDFMKAGG 210
Cdd:PRK12560   52 IDKIVTEEDKGAPLATPVSLLSGKPLAMARWYPYSLS--ELNYNVVEIGSEYFEG-VVYLNGIEKGDRVAIIDDTLSTGG 128

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2029975795 211 TIQGMMSMLEEFKANLVGIGVLVESTDIEER 241
Cdd:PRK12560  129 TVIALIKAIENSGGIVSDVICVIEKTQNNGR 159
PLN02293 PLN02293
adenine phosphoribosyltransferase
 106-234 1.75e-05

adenine phosphoribosyltransferase


Pssm-ID: 177930  Cd Length: 187  Bit Score: 44.28  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 106 TDLLSNPRHINGAGRLFASVFARQPIDAVMTVATKGIPLAYAVANYLDVPVVIARKDNKVTeGPTVSINYVSGSSKriQT 185
Cdd:PLN02293   38 TTLLLDPKAFKDTIDLFVERYRDMGISVVAGIEARGFIFGPPIALAIGAKFVPLRKPGKLP-GEVISEEYVLEYGT--DC 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2029975795 186 MTLAKRSLPEGSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVE 234
Cdd:PLN02293  115 LEMHVGAVEPGERALVIDDLIATGGTLCAAINLLERAGAEVVECACVIE 163
PRK06031 PRK06031
phosphoribosyltransferase; Provisional
 94-237 4.43e-05

phosphoribosyltransferase; Provisional


Pssm-ID: 235678  Cd Length: 233  Bit Score: 43.59  E-value: 4.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795  94 PDRILPGGYLYMTDLLSNPRHINGAGRL---FASVFARQPIDAVMTVATKGIPLAYAVANYLD----VPVVIARK---DN 163
Cdd:PRK06031   45 PIRGLPDGDRALASLIVNQASFEVLDALaehLAEKARAFDPDVVAGLPTLGLTLAAAVARKLGhtryVPLGTSRKfwyRD 124

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2029975795 164 KVTEgPTVSINyVSGSSKRIQtmtLAKRSLP--EGSNVLIIDDFMKAGGTIQGMMSMLEEFKANLVGIGVLVESTD 237
Cdd:PRK06031  125 ELSV-PLSSIT-TPDQGKRLY---IDPRMLPllEGRRVALIDDVISSGASIVAGLRLLAACGIEPAGIGAAMLQSE 195
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 132-232 4.34e-04

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 39.83  E-value: 4.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2029975795 132 DAVMTVATKGIPLAYAVANYLDVPVVIarkdnkvtegpTVSINYVSGSSKRIQTMTLAK--RSLPEGSNVLIIDDFMKAG 209
Cdd:COG2236    33 DVIVAIARGGLVPARILADALGVPDLA-----------SIRVSSYTGTAKRLEEPVVKGplDEDLAGKRVLIVDDVADTG 101

                          90       100
                  ....*....|....*....|...
gi 2029975795 210 GTIQGMMSMLEEFKANLVGIGVL 232
Cdd:COG2236   102 RTLEAVRDLLKEAGPAEVRTAVL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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