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Conserved domains on  [gi|2030565369|gb|QUK52373|]
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tetratricopeptide repeat protein [Treponema pallidum]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 502-797 5.01e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 76.69  E-value: 5.01e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  502 YRAGYHALELDRYEDAHTNFEHA-KQYWKIKHWYFRYARALRDKKQYTRAEQIYTELLfdfrHPKQGSIEYAHMLCNELR 580
Cdd:COG2956     12 YFKGLNYLLNGQPDKAIDLLEEAlELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLL----ERDPDRAEALLELAQDYL 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  581 K---YEQAETTLrRQGLDHHPNDPDILSALGDVYLEwaEEDpaqYEQARKTYQSLIASHGTRDAYLARMMRYFIRTDQLA 657
Cdd:COG2956     88 KaglLDRAEELL-EKLLELDPDDAEALRLLAEIYEQ--EGD---WEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYD 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  658 QVLP-----LKAHFTNTRARIApedLTELsgYLLEKRYesqpsdsltlqskiEDLRALLERAFKADPMSADAAYYLGKFF 732
Cdd:COG2956    162 EAIEalekaLKLDPDCARALLL---LAEL--YLEQGDY--------------EEAIAALERALEQDPDYLPALPRLAELY 222

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2030565369  733 VYNHRKDSARELLQQAVNRYPhmphstvrrtlrEIDAMRLLGTLLLEEKGHAAAREIFTQALTRY 797
Cdd:COG2956    223 EKLGDPEEALELLRKALELDP------------SDDLLLALADLLERKEGLEAALALLERQLRRH 275
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 703-932 4.13e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 70.91  E-value: 4.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  703 KIEDLRALLERAFKADPMSADAAYYLGKFFVYNHRKDSARELLQQAVNRYPHmphstvrrtlrEIDAMRLLGTLLLEEKG 782
Cdd:COG2956     57 EYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPD-----------DAEALRLLAEIYEQEGD 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  783 HAAAREIFTQALTRYRSYIVMrdlppHRTIGKLYRDYadmdyfiyKNYDSALEHYQHARAQLLDTPEVQYKIGYIQHKKN 862
Cdd:COG2956    126 WEKAIEVLERLLKLGPENAHA-----YCELAELYLEQ--------GDYDEAIEALEKALKLDPDCARALLLLAELYLEQG 192

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2030565369  863 NYPEAIRAMNAAYEHNPQDKHLLYGFGTLLCKRGDYFASQGYYEQLLEL--LDAQRTRRGVMLPHIEKADAA 932
Cdd:COG2956    193 DYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELdpSDDLLLALADLLERKEGLEAA 264
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 21-344 9.01e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 9.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369   21 PDTLKSWGTLYDDlPPPESTPdgaQPAPTPerqSAPASASASGPVSAHGQRPFEPDTEASSvASGEEVVQEDAHAPQTRM 100
Cdd:PHA03247  2689 RPTVGSLTSLADP-PPPPPTP---EPAPHA---LVSATPLPPGPAAARQASPALPAAPAPP-AVPAGPATPGGPARPARP 2760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  101 HDSAQEPAAeislfSEERTPETMPTAAWSAPPDPLFETEHAVPPLPLDPEETPVPGEKGLQESAVQEEDAGFNQMPATGG 180
Cdd:PHA03247  2761 PTTAGPPAP-----APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ 2835

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  181 QTSENQ-QHFDALLASLDLDSANGERVVPENADEFAAQVPESlleglhPEDQETKRSQEEPVSYDFPAFDLDQVAPPTPD 259
Cdd:PHA03247  2836 PTAPPPpPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA------PARPPVRRLARPAVSRSTESFALPPDQPERPP 2909

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  260 APDSSNSALTEIEITPALSEHPtQTQETGTTSPQSQTVHADASALGPSASDPNFSPGsadnlvAQFPIEESV---QIPPf 336
Cdd:PHA03247  2910 QPQAPPPPQPQPQPPPPPQPQP-PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG------ALVPGRVAVprfRVPQ- 2981


                   ....*...
gi 2030565369  337 PADGFELP 344
Cdd:PHA03247  2982 PAPSREAP 2989
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 502-797 5.01e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 76.69  E-value: 5.01e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  502 YRAGYHALELDRYEDAHTNFEHA-KQYWKIKHWYFRYARALRDKKQYTRAEQIYTELLfdfrHPKQGSIEYAHMLCNELR 580
Cdd:COG2956     12 YFKGLNYLLNGQPDKAIDLLEEAlELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLL----ERDPDRAEALLELAQDYL 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  581 K---YEQAETTLrRQGLDHHPNDPDILSALGDVYLEwaEEDpaqYEQARKTYQSLIASHGTRDAYLARMMRYFIRTDQLA 657
Cdd:COG2956     88 KaglLDRAEELL-EKLLELDPDDAEALRLLAEIYEQ--EGD---WEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYD 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  658 QVLP-----LKAHFTNTRARIApedLTELsgYLLEKRYesqpsdsltlqskiEDLRALLERAFKADPMSADAAYYLGKFF 732
Cdd:COG2956    162 EAIEalekaLKLDPDCARALLL---LAEL--YLEQGDY--------------EEAIAALERALEQDPDYLPALPRLAELY 222

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2030565369  733 VYNHRKDSARELLQQAVNRYPhmphstvrrtlrEIDAMRLLGTLLLEEKGHAAAREIFTQALTRY 797
Cdd:COG2956    223 EKLGDPEEALELLRKALELDP------------SDDLLLALADLLERKEGLEAALALLERQLRRH 275
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 703-932 4.13e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 70.91  E-value: 4.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  703 KIEDLRALLERAFKADPMSADAAYYLGKFFVYNHRKDSARELLQQAVNRYPHmphstvrrtlrEIDAMRLLGTLLLEEKG 782
Cdd:COG2956     57 EYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPD-----------DAEALRLLAEIYEQEGD 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  783 HAAAREIFTQALTRYRSYIVMrdlppHRTIGKLYRDYadmdyfiyKNYDSALEHYQHARAQLLDTPEVQYKIGYIQHKKN 862
Cdd:COG2956    126 WEKAIEVLERLLKLGPENAHA-----YCELAELYLEQ--------GDYDEAIEALEKALKLDPDCARALLLLAELYLEQG 192

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2030565369  863 NYPEAIRAMNAAYEHNPQDKHLLYGFGTLLCKRGDYFASQGYYEQLLEL--LDAQRTRRGVMLPHIEKADAA 932
Cdd:COG2956    193 DYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELdpSDDLLLALADLLERKEGLEAA 264
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 480-983 2.89e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 54.70  E-value: 2.89e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  480 FILSLAVLSWHFLYKPLHAHLSYRAGYHALELDRYEDAHTNFEHAKQYWKiKHWYFRYARALRD--KKQYTRAEQIYTEL 557
Cdd:TIGR02917  209 IELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAP-NSPLAHYLKALVDfqKKNYEDARETLQDA 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  558 L-FDFRHPKqgSIEYAHMLCNELRKYEQAETTLRrQGLDHHPNDPDILSALGDVYLEwaeedPAQYEQARKTYQSLIASH 636
Cdd:TIGR02917  288 LkSAPEYLP--ALLLAGASEYQLGNLEQAYQYLN-QILKYAPNSHQARRLLASIQLR-----LGRVDEAIATLSPALGLD 359

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  637 gTRD---------AYLARMM-----RYFIRTDQLAQVLPLKA------HFTNTRARIAPEDLTELS-------------- 682
Cdd:TIGR02917  360 -PDDpaalsllgeAYLALGDfekaaEYLAKATELDPENAAARtqlgisKLSQGDPSEAIADLETAAqldpelgradllli 438

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  683 -GYL-----------LEKRYESQPSDSLT---------LQSKIEDLRALLERAFKADPMSADAAYYLGKFFVYNHRKDSA 741
Cdd:TIGR02917  439 lSYLrsgqfdkalaaAKKLEKKQPDNASLhnllgaiylGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDA 518

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  742 RELLQQAVNRYPHmphstvrrtlrEIDAMRLLGTLLLEEKGHAAAREIFTQALTRY-----------RSYI----VMRDL 806
Cdd:TIGR02917  519 IQRFEKVLTIDPK-----------NLRAILALAGLYLRTGNEEEAVAWLEKAAELNpqeiepalalaQYYLgkgqLKKAL 587

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  807 PPHRTIGKLYRD---YADM---DYFIYKNYDSALEHYQHARAQLLDTPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQ 880
Cdd:TIGR02917  588 AILNEAADAAPDspeAWLMlgrAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPD 667

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  881 DKHLLYGFGTLLCKRGDYFASQgyyeQLLELLDAQRTRRGVMLP-----HIEKAD-----AAFVDLYMRTCNNLGVVlhR 950
Cdd:TIGR02917  668 NTEAQIGLAQLLLAAKRTESAK----KIAKSLQKQHPKAALGFElegdlYLRQKDypaaiQAYRKALKRAPSSQNAI--K 741

                          570       580       590
                   ....*....|....*....|....*....|...
gi 2030565369  951 LATTHGDSRKNARALTLFAessrAWdaLTRHPE 983
Cdd:TIGR02917  742 LHRALLASGNTAEAVKTLE----AW--LKTHPN 768
PHA03247 PHA03247
large tegument protein UL36; Provisional
 21-344 9.01e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 9.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369   21 PDTLKSWGTLYDDlPPPESTPdgaQPAPTPerqSAPASASASGPVSAHGQRPFEPDTEASSvASGEEVVQEDAHAPQTRM 100
Cdd:PHA03247  2689 RPTVGSLTSLADP-PPPPPTP---EPAPHA---LVSATPLPPGPAAARQASPALPAAPAPP-AVPAGPATPGGPARPARP 2760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  101 HDSAQEPAAeislfSEERTPETMPTAAWSAPPDPLFETEHAVPPLPLDPEETPVPGEKGLQESAVQEEDAGFNQMPATGG 180
Cdd:PHA03247  2761 PTTAGPPAP-----APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ 2835

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  181 QTSENQ-QHFDALLASLDLDSANGERVVPENADEFAAQVPESlleglhPEDQETKRSQEEPVSYDFPAFDLDQVAPPTPD 259
Cdd:PHA03247  2836 PTAPPPpPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA------PARPPVRRLARPAVSRSTESFALPPDQPERPP 2909

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  260 APDSSNSALTEIEITPALSEHPtQTQETGTTSPQSQTVHADASALGPSASDPNFSPGsadnlvAQFPIEESV---QIPPf 336
Cdd:PHA03247  2910 QPQAPPPPQPQPQPPPPPQPQP-PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG------ALVPGRVAVprfRVPQ- 2981


                   ....*...
gi 2030565369  337 PADGFELP 344
Cdd:PHA03247  2982 PAPSREAP 2989
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 255-332 5.29e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.26  E-value: 5.29e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2030565369  255 PPTPDAPDSSNSAlTEIEITPALSEHPTQTQETGTTSPQSQTVHADASalgPSASDPNFSPGSADNLVAQFPIEESVQ 332
Cdd:TIGR00601   88 AATPTSAPTPTPS-PPASPASGMSAAPASAVEEKSPSEESATATAPES---PSTSVPSSGSDAASTLVVGSERETTIE 161
Ebola_NP pfam05505
Ebola nucleoprotein; This family consists of Ebola and Marburg virus nucleoproteins. These ...
 29-249 8.45e-03

Ebola nucleoprotein; This family consists of Ebola and Marburg virus nucleoproteins. These proteins are responsible for encapsidation of genomic RNA. It has been found that nucleoprotein DNA vaccines can offer protection from the virus.


Pssm-ID: 398905  Cd Length: 717  Bit Score: 40.10  E-value: 8.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369   29 TLYDDLPPPESTPDGAQPAPTPERQSAPASASASGPVSAHGQrPFEPDTEASSVASGEEVVQEDAHAPQTRMHDSAQEPA 108
Cdd:pfam05505  474 DLEDTKPVPNRSTKGGQQKNSQKGQHIEGRQTQSRPIQNVPG-PHRTIHHASAPLTDNDRRNEPSGSTSPRMLTPINEEA 552

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  109 AEI--------------SLFSEERTPETMPTAAWSAPPDPLFETEHAVPPLPLDPEET-PVPGEKGLQESAVQEEDAGFN 173
Cdd:pfam05505  553 DPLddaddetsslppleSDDEEQDRDGTSNRTPTVAPPAPVYRDHSEKKELPQDEQQDqDHTQEARNQDSDNTQSEHSFE 632

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2030565369  174 QMPAtggQTSENQQHFDALLaSLDLDSANGERVVPENADEFAaqVPESLLEGLHPEDQETKRSQEE--PVSYDFPAFD 249
Cdd:pfam05505  633 EMYR---HILRSQGPFDAVL-YYHMMKDEPVVFSTSDGKEYT--YPDSLEEEYPPWLTEKEAMNEEnrFVTLDGQQFY 704
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 502-797 5.01e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 76.69  E-value: 5.01e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  502 YRAGYHALELDRYEDAHTNFEHA-KQYWKIKHWYFRYARALRDKKQYTRAEQIYTELLfdfrHPKQGSIEYAHMLCNELR 580
Cdd:COG2956     12 YFKGLNYLLNGQPDKAIDLLEEAlELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLL----ERDPDRAEALLELAQDYL 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  581 K---YEQAETTLrRQGLDHHPNDPDILSALGDVYLEwaEEDpaqYEQARKTYQSLIASHGTRDAYLARMMRYFIRTDQLA 657
Cdd:COG2956     88 KaglLDRAEELL-EKLLELDPDDAEALRLLAEIYEQ--EGD---WEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYD 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  658 QVLP-----LKAHFTNTRARIApedLTELsgYLLEKRYesqpsdsltlqskiEDLRALLERAFKADPMSADAAYYLGKFF 732
Cdd:COG2956    162 EAIEalekaLKLDPDCARALLL---LAEL--YLEQGDY--------------EEAIAALERALEQDPDYLPALPRLAELY 222

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2030565369  733 VYNHRKDSARELLQQAVNRYPhmphstvrrtlrEIDAMRLLGTLLLEEKGHAAAREIFTQALTRY 797
Cdd:COG2956    223 EKLGDPEEALELLRKALELDP------------SDDLLLALADLLERKEGLEAALALLERQLRRH 275
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 580-910 1.12e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 75.54  E-value: 1.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  580 RKYEQAETTLRrQGLDHHPNDPDILSALGDVYLEWAEedpaqYEQARKTYQSLIASHGTRDAYLArmmryfirtdQLAQV 659
Cdd:COG2956     22 GQPDKAIDLLE-EALELDPETVEAHLALGNLYRRRGE-----YDRAIRIHQKLLERDPDRAEALL----------ELAQD 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  660 lplkahftntrariapedltelsgYLLEKRYEsqpsdsltlqskiedlRA--LLERAFKADPMSADAAYYLGKFFVYNHR 737
Cdd:COG2956     86 ------------------------YLKAGLLD----------------RAeeLLEKLLELDPDDAEALRLLAEIYEQEGD 125

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  738 KDSARELLQQAVNRYPHMPHstvrrtlreidAMRLLGTLLLEEKGHAAAREIFTQALTRYRsyivmRDLPPHRTIGKLYR 817
Cdd:COG2956    126 WEKAIEVLERLLKLGPENAH-----------AYCELAELYLEQGDYDEAIEALEKALKLDP-----DCARALLLLAELYL 189

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  818 DYadmdyfiyKNYDSALEHYQHARAQLLDTPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQDkHLLYGFGTLLCKRGD 897
Cdd:COG2956    190 EQ--------GDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD-DLLLALADLLERKEG 260

                          330
                   ....*....|...
gi 2030565369  898 YFASQGYYEQLLE 910
Cdd:COG2956    261 LEAALALLERQLR 273
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 703-932 4.13e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 70.91  E-value: 4.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  703 KIEDLRALLERAFKADPMSADAAYYLGKFFVYNHRKDSARELLQQAVNRYPHmphstvrrtlrEIDAMRLLGTLLLEEKG 782
Cdd:COG2956     57 EYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPD-----------DAEALRLLAEIYEQEGD 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  783 HAAAREIFTQALTRYRSYIVMrdlppHRTIGKLYRDYadmdyfiyKNYDSALEHYQHARAQLLDTPEVQYKIGYIQHKKN 862
Cdd:COG2956    126 WEKAIEVLERLLKLGPENAHA-----YCELAELYLEQ--------GDYDEAIEALEKALKLDPDCARALLLLAELYLEQG 192

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2030565369  863 NYPEAIRAMNAAYEHNPQDKHLLYGFGTLLCKRGDYFASQGYYEQLLEL--LDAQRTRRGVMLPHIEKADAA 932
Cdd:COG2956    193 DYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELdpSDDLLLALADLLERKEGLEAA 264
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 726-911 7.76e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 70.14  E-value: 7.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  726 YYLGKFFVYNHRKDSARELLQQAVNRYPHmphstvrrtlrEIDAMRLLGTLLLEEKGHAAAREIFTQALTRYRsyivmRD 805
Cdd:COG2956     12 YFKGLNYLLNGQPDKAIDLLEEALELDPE-----------TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDP-----DR 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  806 LPPHRTIGKLYRDYadmdyfiyKNYDSALEHYQHARAQLLDTPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQDKHLL 885
Cdd:COG2956     76 AEALLELAQDYLKA--------GLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAY 147

                          170       180
                   ....*....|....*....|....*.
gi 2030565369  886 YGFGTLLCKRGDYFASQGYYEQLLEL 911
Cdd:COG2956    148 CELAELYLEQGDYDEAIEALEKALKL 173
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
716-916 2.72e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 67.72  E-value: 2.72e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  716 KADPMSADAAYYLGKFFVYNHRKDSARELLQQAVNRYPhmphstvrrtlREIDAMRLLGTLLLEEKGHAAAREIFTQALT 795
Cdd:COG0457      2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDP-----------DDAEALYNLGLAYLRLGRYEEALADYEQALE 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  796 ryrsyIVMRDLPPHRTIGKLYRDYadmdyfiyKNYDSALEHYQHARAQLLDTPEVQYKIGYIQHKKNNYPEAIRAMNAAY 875
Cdd:COG0457     71 -----LDPDDAEALNNLGLALQAL--------GRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERAL 137

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 2030565369  876 EHNPQDKHLLYGFGTLLCKRGDYFASQGYYEQLLELLDAQR 916
Cdd:COG0457    138 ELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAAL 178
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 644-933 1.46e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 61.93  E-value: 1.46e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  644 ARMMRYFIRTDQLAQVLPLKAHFTNTRARIAPEDLTELSGYLLEKRYESQPSDSLTLQSkIEDLRALLERAFKADPMSAD 723
Cdd:COG3914      1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAAL-LALAAGEAAAAAAALLLLAA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  724 AAYYLGKFFVYNHRKDSARELLQQAVNRYPHMPhstvrrtlreiDAMRLLGTLLLEEKGHAAAREIFTQALTryrsyIVM 803
Cdd:COG3914     80 LLELAALLLQALGRYEEALALYRRALALNPDNA-----------EALFNLGNLLLALGRLEEALAALRRALA-----LNP 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  804 RDLPPHRTIGKLYRDYADMDYfiyknydsALEHYQHARAQLLDTPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQDKH 883
Cdd:COG3914    144 DFAEAYLNLGEALRRLGRLEE--------AIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNAD 215

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 2030565369  884 LLYGFGTLLCKRGDYFASQGYYEQLLELLDAQRTRRGVMLPHIEKADAAF 933
Cdd:COG3914    216 AHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAE 265
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 824-921 1.12e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 54.63  E-value: 1.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  824 YFIYKNYDSALEHYQHARAQLLDTPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQDKHLLYGFGTLLCKRGDYFASQG 903
Cdd:COG4235     27 YLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIA 106

                           90
                   ....*....|....*...
gi 2030565369  904 YYEQLLELLDAQRTRRGV 921
Cdd:COG4235    107 AWQKLLALLPADAPARLL 124
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 475-675 5.13e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.93  E-value: 5.13e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  475 AAILIFILSLAVLSWHFLYKPLHAHLSYRAGYHALELDRYEDAHTNFEHAKQ----YWKIkhwYFRYARALRDKKQYTRA 550
Cdd:COG3914     55 AAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALAlnpdNAEA---LFNLGNLLLALGRLEEA 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  551 EQIYTELL-FDFRHPkQGSIEYAHMLcNELRKYEQAETTLRRqGLDHHPNDPDILSALGDVYlewaeEDPAQYEQARKTY 629
Cdd:COG3914    132 LAALRRALaLNPDFA-EAYLNLGEAL-RRLGRLEEAIAALRR-ALELDPDNAEALNNLGNAL-----QDLGRLEEAIAAY 203

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2030565369  630 QSLIASHGTRDAYLARMMRYFIRT---DQLAQVLPLKAHFTNTRARIAP 675
Cdd:COG3914    204 RRALELDPDNADAHSNLLFALRQAcdwEVYDRFEELLAALARGPSELSP 252
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 765-911 8.62e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.12  E-value: 8.62e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  765 REIDAMRLLGTLLLEEKGHAAAREIFTQALTRYRSyivmrDLPPHRTIGKLYRDYadmdyfiyKNYDSALEHYQHARAQL 844
Cdd:COG4783      2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPD-----NPEAFALLGEILLQL--------GDLDEAIVLLHEALELD 68

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2030565369  845 LDTPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQDKHLLYGFGTLLCKRGDYFASQGYYEQLLEL 911
Cdd:COG4783     69 PDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 722-881 9.40e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.12  E-value: 9.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  722 ADAAYYLGKFFVYNHRKDSARELLQQAVNRYPHMPhstvrrtlreiDAMRLLGTLLLEEKGHAAAREIFTQALTRYRSyi 801
Cdd:COG4783      4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNP-----------EAFALLGEILLQLGDLDEAIVLLHEALELDPD-- 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  802 vmrDLPPHRTIGKLYRDYadmdyfiyKNYDSALEHYQHARAQLLDTPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQD 881
Cdd:COG4783     71 ---EPEARLNLGLALLKA--------GDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 764-911 1.12e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 52.27  E-value: 1.12e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  764 LREIDAMRLLGTLLLEEKGHAAAREIFTQALTRYRSYIVMRDLPPHRTIGKLYRDYADMDYFIYKNYDSALEHYQHARAQ 843
Cdd:COG5010      4 LEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQL 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2030565369  844 LLDTPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQDKHLLYGFGTLLCKRGDYFASQGYYEQLLEL 911
Cdd:COG5010     84 DPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGT 151
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
709-919 2.15e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.09  E-value: 2.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  709 ALLERAFKADPMSADAAYYLGKFFVYNHRKDSARELLQQAVNRYPHMPhstvrrtlreiDAMRLLGTLLLEEKGHAAARE 788
Cdd:COG0457     29 EDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDA-----------EALNNLGLALQALGRYEEALE 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  789 IFTQALTryrsyIVMRDLPPHRTIGKLYRDYadmdyfiyKNYDSALEHYQHARAQLLDTPEVQYKIGYIQHKKNNYPEAI 868
Cdd:COG0457     98 DYDKALE-----LDPDDAEALYNLGLALLEL--------GRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEAL 164

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2030565369  869 RAMNAAYEHNPQDKHLLYGFGTLLCKRGDYFASQGYYEQLLELLDAQRTRR 919
Cdd:COG0457    165 ELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILT 215
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 480-983 2.89e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 54.70  E-value: 2.89e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  480 FILSLAVLSWHFLYKPLHAHLSYRAGYHALELDRYEDAHTNFEHAKQYWKiKHWYFRYARALRD--KKQYTRAEQIYTEL 557
Cdd:TIGR02917  209 IELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAP-NSPLAHYLKALVDfqKKNYEDARETLQDA 287

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  558 L-FDFRHPKqgSIEYAHMLCNELRKYEQAETTLRrQGLDHHPNDPDILSALGDVYLEwaeedPAQYEQARKTYQSLIASH 636
Cdd:TIGR02917  288 LkSAPEYLP--ALLLAGASEYQLGNLEQAYQYLN-QILKYAPNSHQARRLLASIQLR-----LGRVDEAIATLSPALGLD 359

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  637 gTRD---------AYLARMM-----RYFIRTDQLAQVLPLKA------HFTNTRARIAPEDLTELS-------------- 682
Cdd:TIGR02917  360 -PDDpaalsllgeAYLALGDfekaaEYLAKATELDPENAAARtqlgisKLSQGDPSEAIADLETAAqldpelgradllli 438

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  683 -GYL-----------LEKRYESQPSDSLT---------LQSKIEDLRALLERAFKADPMSADAAYYLGKFFVYNHRKDSA 741
Cdd:TIGR02917  439 lSYLrsgqfdkalaaAKKLEKKQPDNASLhnllgaiylGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDA 518

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  742 RELLQQAVNRYPHmphstvrrtlrEIDAMRLLGTLLLEEKGHAAAREIFTQALTRY-----------RSYI----VMRDL 806
Cdd:TIGR02917  519 IQRFEKVLTIDPK-----------NLRAILALAGLYLRTGNEEEAVAWLEKAAELNpqeiepalalaQYYLgkgqLKKAL 587

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  807 PPHRTIGKLYRD---YADM---DYFIYKNYDSALEHYQHARAQLLDTPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQ 880
Cdd:TIGR02917  588 AILNEAADAAPDspeAWLMlgrAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPD 667

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  881 DKHLLYGFGTLLCKRGDYFASQgyyeQLLELLDAQRTRRGVMLP-----HIEKAD-----AAFVDLYMRTCNNLGVVlhR 950
Cdd:TIGR02917  668 NTEAQIGLAQLLLAAKRTESAK----KIAKSLQKQHPKAALGFElegdlYLRQKDypaaiQAYRKALKRAPSSQNAI--K 741

                          570       580       590
                   ....*....|....*....|....*....|...
gi 2030565369  951 LATTHGDSRKNARALTLFAessrAWdaLTRHPE 983
Cdd:TIGR02917  742 LHRALLASGNTAEAVKTLE----AW--LKTHPN 768
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 697-843 1.26e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.03  E-value: 1.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  697 SLTLQSKIEDLRALLERAFKADPMSADAAYYLGKFFVYNHRKDSARELLQQAVNRYPhmphstvrrtlREIDAMRLLGTL 776
Cdd:COG4783     13 ALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDP-----------DEPEARLNLGLA 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2030565369  777 LLEEKGHAAAREIFTQALTRYRSYIvmrdlPPHRTIGKLYRDYADmdyfiyknYDSALEHYQHARAQ 843
Cdd:COG4783     82 LLKAGDYDEALALLEKALKLDPEHP-----EAYLRLARAYRALGR--------PDEAIAALEKALEL 135
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 704-797 1.55e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 48.06  E-value: 1.55e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  704 IEDLRALLERaFKADPMSADAAYYLGKFFVYNHRKDSARELLQQAVNRYPHMPhstvrrtlREIDAMRLLGTLLLEEKGH 783
Cdd:COG1729     13 IAAFKAFLKR-YPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSP--------KAPDALLKLGLSYLELGDY 83

                           90
                   ....*....|....
gi 2030565369  784 AAAREIFTQALTRY 797
Cdd:COG1729     84 DKARATLEELIKKY 97
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
828-911 5.97e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.55  E-value: 5.97e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  828 KNYDSALEHYQHARAQLLDTPEVQYKIGYIQHKKNNYPEAIrAMNAAYEHNPQDKHLLYGFGTLLCKRGDYFASQGYYEQ 907
Cdd:COG3063      6 GDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLER 84


                   ....
gi 2030565369  908 LLEL 911
Cdd:COG3063     85 ALEL 88
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 598-909 1.26e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 49.31  E-value: 1.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  598 PNDPDILSALGDVYLEwaEEDPAQYEQARKTYQSLIASHGTRDAYLARMMryfIRTDQLAQVLplkAHFTNTRArIAPED 677
Cdd:TIGR02917   53 PNDAEARFLLGKIYLA--LGDYAAAEKELRKALSLGYPKNQVLPLLARAY---LLQGKFQQVL---DELPGKTL-LDDEG 123

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  678 LTELSGYLlekryesqpSDSLTLQSKIEDLRALLERAFKADPMSADAAYYLGKFFVYNHRKDSARELLQQAVNRYPhmph 757
Cdd:TIGR02917  124 AAELLALR---------GLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADP---- 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  758 stvrrtlREIDAMRLLGTLLLEEKGHAAAREIFTQALTryrsyIVMRDLPPHrtigklyrdYADMDYFIYKN-YDSALEH 836
Cdd:TIGR02917  191 -------GNVDALLLKGDLLLSLGNIELALAAYRKAIA-----LRPNNIAVL---------LALATILIEAGeFEEAEKH 249

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2030565369  837 YQHARAQLLDTPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQDKHLLYGFGTLLCKRGDYFASQGYYEQLL 909
Cdd:TIGR02917  250 ADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQIL 322
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 706-844 1.81e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.38  E-value: 1.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  706 DLRALLERAFKADPMSADAAYYLGKFFVYNHRKDSARELLQQAVNRYPhmphstvrrtlREIDAMRLLGTLLLEEKGHAA 785
Cdd:COG4235      1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDP-----------DNADALLDLAEALLAAGDTEE 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2030565369  786 AREIFTQALTRYrsyivmrdlPPHRTigklYRDYADMDYFIYKNYDSALEHYQHARAQL 844
Cdd:COG4235     70 AEELLERALALD---------PDNPE----ALYLLGLAAFQQGDYAEAIAAWQKLLALL 115
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 686-794 2.25e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.00  E-value: 2.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  686 LEKRYESQPSD---------SLTLQSKIEDLRALLERAFKADPMSADAAYYLGKFFVYNHRKDSARELLQQAVNRYPHmp 756
Cdd:COG4235      6 LRQALAANPNDaegwlllgrAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPD-- 83

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2030565369  757 hstvrrtlrEIDAMRLLGTLLLEEKGHAAAREIFTQAL 794
Cdd:COG4235     84 ---------NPEALYLLGLAAFQQGDYAEAIAAWQKLL 112
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 822-910 2.28e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 44.60  E-value: 2.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  822 MDYFIYKNYDSALEHYQHARAQLLD---TPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQDKHL---LYGFGTLLCKR 895
Cdd:COG1729      1 KALLKAGDYDEAIAAFKAFLKRYPNsplAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKApdaLLKLGLSYLEL 80

                           90
                   ....*....|....*
gi 2030565369  896 GDYFASQGYYEQLLE 910
Cdd:COG1729     81 GDYDKARATLEELIK 95
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 538-794 1.06e-04

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 45.67  E-value: 1.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  538 ARALRDKKQYTRAEQIYTELLFDFRHPKQGsIEYAHMLCNELRKYEQAETTLRRQGLDHHPNDPDILSALGDVYLEWAEE 617
Cdd:COG3071     92 AELLLDQGQAEQALATLEALRAGAPRHPQV-LRLLLQAYRQLGDWEELLELLPALRKHKALSAEEAQALERRAYLGLLRQ 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  618 DPAQYEQARKTYQSLIASHGTRDAYLARMMRYFIRTDQLAQVLplkahftntrariapedltelsgYLLEKRYESQPSDS 697
Cdd:COG3071    171 AARDAEALKALWKALPRAERRDPELAAAYARALIALGDHDEAE-----------------------RLLREALKRQWDPR 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  698 LTLQ------SKIEDLRALLERAFKADPMSADAAYYLGKFFVYNHRKDSARELLQQAVNRYPhmphstvrrtlrEIDAMR 771
Cdd:COG3071    228 LVRLygrlqgGDPAKQLKRAEKWLKKHPNDPDLLLALGRLCLRNQLWGKAREYLEAALALRP------------SAEAYA 295

                          250       260
                   ....*....|....*....|...
gi 2030565369  772 LLGTLLLEEKGHAAAREIFTQAL 794
Cdd:COG3071    296 ELARLLEQLGDPEEAAEHYRKAL 318
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 597-753 3.26e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.69  E-value: 3.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  597 HPNDPDILSALGDVYLewAEEDPAQYEQA-RKTYQslIASHGTRDAYLARMMRYFIRTDQLAQVLP--LKAHFTNTRARI 673
Cdd:TIGR02917  699 HPKAALGFELEGDLYL--RQKDYPAAIQAyRKALK--RAPSSQNAIKLHRALLASGNTAEAVKTLEawLKTHPNDAVLRT 774

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  674 ApedLTELsgYLLEKRY-----------ESQPSDSLTLQS------KIEDLRALL--ERAFKADPMSADAAYYLGKFFVY 734
Cdd:TIGR02917  775 A---LAEL--YLAQKDYdkaikhyqtvvKKAPDNAVVLNNlawlylELKDPRALEyaERALKLAPNIPAILDTLGWLLVE 849

                          170
                   ....*....|....*....
gi 2030565369  735 NHRKDSARELLQQAVNRYP 753
Cdd:TIGR02917  850 KGEADRALPLLRKAVNIAP 868
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 636-796 3.98e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.87  E-value: 3.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  636 HGTRDAYLARMMRYFIRTDQLAQVLPLKAHFTNTRARIAPEDLTELSGYLLEKRYESQPSDSLTLQSKIEDLRALLERAF 715
Cdd:COG5010      2 RALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  716 KADPMSADAAYYLGKFFVYNHRKDSARELLQQAVNRYPHMPhstvrrtlreiDAMRLLGTLLLEEKGHAAAREIFTQALT 795
Cdd:COG5010     82 QLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNP-----------NAYSNLAALLLSLGQDDEAKAALQRALG 150


                   .
gi 2030565369  796 R 796
Cdd:COG5010    151 T 151
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 534-658 8.57e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.56  E-value: 8.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  534 YFRYARALRDKKQYTRAEQIYTELLFDFRHPKQGSIEYAHMLcNELRKYEQAETTLRRqGLDHHPNDPDILSALGDVYLE 613
Cdd:COG4783      7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEIL-LQLGDLDEAIVLLHE-ALELDPDEPEARLNLGLALLK 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2030565369  614 wAEedpaQYEQARKTYQSLIASHGTRDAYLARMMRYFIRTDQLAQ 658
Cdd:COG4783     85 -AG----DYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDE 124
PHA03247 PHA03247
large tegument protein UL36; Provisional
 21-344 9.01e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 9.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369   21 PDTLKSWGTLYDDlPPPESTPdgaQPAPTPerqSAPASASASGPVSAHGQRPFEPDTEASSvASGEEVVQEDAHAPQTRM 100
Cdd:PHA03247  2689 RPTVGSLTSLADP-PPPPPTP---EPAPHA---LVSATPLPPGPAAARQASPALPAAPAPP-AVPAGPATPGGPARPARP 2760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  101 HDSAQEPAAeislfSEERTPETMPTAAWSAPPDPLFETEHAVPPLPLDPEETPVPGEKGLQESAVQEEDAGFNQMPATGG 180
Cdd:PHA03247  2761 PTTAGPPAP-----APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ 2835

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  181 QTSENQ-QHFDALLASLDLDSANGERVVPENADEFAAQVPESlleglhPEDQETKRSQEEPVSYDFPAFDLDQVAPPTPD 259
Cdd:PHA03247  2836 PTAPPPpPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAA------PARPPVRRLARPAVSRSTESFALPPDQPERPP 2909

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  260 APDSSNSALTEIEITPALSEHPtQTQETGTTSPQSQTVHADASALGPSASDPNFSPGsadnlvAQFPIEESV---QIPPf 336
Cdd:PHA03247  2910 QPQAPPPPQPQPQPPPPPQPQP-PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLG------ALVPGRVAVprfRVPQ- 2981


                   ....*...
gi 2030565369  337 PADGFELP 344
Cdd:PHA03247  2982 PAPSREAP 2989
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 584-753 1.34e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.99  E-value: 1.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  584 QAETTLRRQgLDHHPNDPDILSALGDVYLEWAeedpaQYEQARKTYQSLIashgtrdaylarmmryfirtdqlaqvlplk 663
Cdd:COG4235      1 EAIARLRQA-LAANPNDAEGWLLLGRAYLRLG-----RYDEALAAYEKAL------------------------------ 44

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  664 ahftntraRIAPEDLTELSGYllekryesqpSDSLTLQSKIEDLRALLERAFKADPMSADAAYYLGKFFVYNHRKDSARE 743
Cdd:COG4235     45 --------RLDPDNADALLDL----------AEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIA 106

                          170
                   ....*....|
gi 2030565369  744 LLQQAVNRYP 753
Cdd:COG4235    107 AWQKLLALLP 116
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 502-636 1.37e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.18  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  502 YRAGYHALELDRYEDAHTNFEHA-KQYWKIKHWYFRYARALRDKKQYTRAEQIYTELLFdfRHPKQGSIEYAH-MLCNEL 579
Cdd:COG4783      8 YALAQALLLAGDYDEAEALLEKAlELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALE--LDPDEPEARLNLgLALLKA 85

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2030565369  580 RKYEQAETTLRRqGLDHHPNDPDILSALGDVYLEWaeedpAQYEQARKTYQSLIASH 636
Cdd:COG4783     86 GDYDEALALLEK-ALKLDPEHPEAYLRLARAYRAL-----GRPDEAIAALEKALELD 136
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 35-144 1.66e-03

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 42.41  E-value: 1.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369   35 PPPEST------PDgaqPAPTPERQSAPASASASGPVSAhGQRPFEPDTEASSVASGEEvvqEDAHAPQTRMHDSAQEPA 108
Cdd:PHA03269    42 PAPAPHqaasraPD---PAVAPTSAASRKPDLAQAPTPA-ASEKFDPAPAPHQAASRAP---DPAVAPQLAAAPKPDAAE 114

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2030565369  109 AEISLFSEERTPETMPTAAWSAPPDPLFETEHAVPP 144
Cdd:PHA03269   115 AFTSAAQAHEAPADAGTSAASKKPDPAAHTQHSPPP 150
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
574-798 2.44e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 2.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  574 MLCNELRKYEQAETTLRRqGLDHHPNDPDILSALGDVYLEWaeedpAQYEQARKTYQSLIASHGTRDAYLARMMRYFIRT 653
Cdd:COG0457     16 LAYRRLGRYEEAIEDYEK-ALELDPDDAEALYNLGLAYLRL-----GRYEEALADYEQALELDPDDAEALNNLGLALQAL 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  654 DQLAQVLPL--KAhftntrARIAPEDLTELSGYllekryesqpSDSLTLQSKIEDLRALLERAFKADPMSADAAYYLGKF 731
Cdd:COG0457     90 GRYEEALEDydKA------LELDPDDAEALYNL----------GLALLELGRYDEAIEAYERALELDPDDADALYNLGIA 153

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2030565369  732 FVYNHRKDSARELLQQAVNRYPHMPHSTVRRTLREIDAMRLLGTLLLEEKGHAAAREIFTQALTRYR 798
Cdd:COG0457    154 LEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALA 220
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
701-799 2.53e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.23  E-value: 2.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  701 QSKIEDLRALLERAFKADPMSADAAYYLGKFFVYNHRKDSARElLQQAVNRYPHMPhstvrrtlreiDAMRLLGTLLLEE 780
Cdd:COG3063      5 LGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNA-----------EALLNLAELLLEL 72

                           90
                   ....*....|....*....
gi 2030565369  781 KGHAAAREIFTQALTRYRS 799
Cdd:COG3063     73 GDYDEALAYLERALELDPS 91
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
493-728 2.70e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.76  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  493 YKPLHAHLSYRAGYHALELDRYEDAHTNFEHA----KQYWKIkhwYFRYARALRDKKQYTRAEQIYTELLfdfrhpkQGS 568
Cdd:COG0457      3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKAleldPDDAEA---LYNLGLAYLRLGRYEEALADYEQAL-------ELD 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  569 IEYAHMLCN------ELRKYEQAETTLrRQGLDHHPNDPDILSALGDVYLEWAEEDPAQ--YEQARKTYQSLIASHGTRD 640
Cdd:COG0457     73 PDDAEALNNlglalqALGRYEEALEDY-DKALELDPDDAEALYNLGLALLELGRYDEAIeaYERALELDPDDADALYNLG 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  641 AYLARMMRYFIRTDQLAQVLPLKAHFTNTRARIAPEDLTELSGYLLEKRYESQPSDSLTLQSKIEDLRALLERAFKADPM 720
Cdd:COG0457    152 IALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLL 231


                   ....*...
gi 2030565369  721 SADAAYYL 728
Cdd:COG0457    232 ALRLAALA 239
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 833-911 2.78e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.83  E-value: 2.78e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2030565369  833 ALEHYQHARAQLLDTPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQDKHLLYGFGTLLCKRGDYFASQGYYEQLLEL 911
Cdd:COG4235      2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 597-911 2.82e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 2.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  597 HPNDPDILSALGDVYLEWAEEdpaqyEQARKTYQSLIASHGTRDAYLARMMRYFIRTDQLAQVLPLkahfTNTRARIAPe 676
Cdd:TIGR02917  529 DPKNLRAILALAGLYLRTGNE-----EEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAI----LNEAADAAP- 598

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  677 dltelsgylLEKRYESQPSDSLTLQSKIEDLRALLERAFKADPMSADAAYYLGKFFVYNHRKDSARELLQQAVNRYPHMp 756
Cdd:TIGR02917  599 ---------DSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDN- 668

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  757 hstvrrtlreIDAMRLLGTLLLEEKGHAAAREIFTQALTRYrsyivmrdlPPHRTIGKLYRDYadmdYFIYKNYDSALEH 836
Cdd:TIGR02917  669 ----------TEAQIGLAQLLLAAKRTESAKKIAKSLQKQH---------PKAALGFELEGDL----YLRQKDYPAAIQA 725

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2030565369  837 YQHArAQLLDTPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQDKHLLYGFGTLLCKRGDYFASQGYYEQLLEL 911
Cdd:TIGR02917  726 YRKA-LKRAPSSQNAIKLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKK 799
PHA03247 PHA03247
large tegument protein UL36; Provisional
 34-477 4.25e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 4.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369   34 LPPPESTPDGAQPAPTPERQSAPASASASGPVSAHGQRPFEPDTEASSVASGEEVVQEDAHA------PQTRMHDSAQEP 107
Cdd:PHA03247  2612 APPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAaqasspPQRPRRRAARPT 2691

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  108 AAEISLFSE----ERTPETMPTAAWSAPPDPL--FETEHAVPPLPLDPEETPVPgekglQESAVQEEDAGFNQMPATGGQ 181
Cdd:PHA03247  2692 VGSLTSLADppppPPTPEPAPHALVSATPLPPgpAAARQASPALPAAPAPPAVP-----AGPATPGGPARPARPPTTAGP 2766

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  182 TSEnqqhfdallASLDLDSANGERVVPENADEFAAQVPESLLEGLHPEDQetkrsqeePVSYDFPAFDLDQVAPPTPDAP 261
Cdd:PHA03247  2767 PAP---------APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP--------PAAVLAPAAALPPAASPAGPLP 2829

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  262 DSSNSALTEIEITPALSEHPTQTQetGTTSPQSQTVHADASalGPSASDPNFSPGSADNLVAQFPIEESVQIPPFPADGF 341
Cdd:PHA03247  2830 PPTSAQPTAPPPPPGPPPPSLPLG--GSVAPGGDVRRRPPS--RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  342 ELPgkfqefaRESESPyfsPDTTADADQAQTISETEYQRFLQRLDALPLPvriavqeylsseeTSDKEGyalissiANNA 421
Cdd:PHA03247  2906 ERP-------PQPQAP---PPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP-------------TTDPAG-------AGEP 2955

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2030565369  422 SPKAVATQLEHILKKPLHIPRKFERKSAAAHEREKSSLPYIAKHTVLPLT--ASSAAI 477
Cdd:PHA03247  2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSswASSLAL 3013
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 255-332 5.29e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.26  E-value: 5.29e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2030565369  255 PPTPDAPDSSNSAlTEIEITPALSEHPTQTQETGTTSPQSQTVHADASalgPSASDPNFSPGSADNLVAQFPIEESVQ 332
Cdd:TIGR00601   88 AATPTSAPTPTPS-PPASPASGMSAAPASAVEEKSPSEESATATAPES---PSTSVPSSGSDAASTLVVGSERETTIE 161
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
822-911 5.77e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.51  E-value: 5.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  822 MDYFIYKNYDSALEHYQHARAQLLDTPEVQYKIGYIQHKKNNYPEAIRAMNAAYEHNPQDKHLLYGFGTLLCKRGDYFAS 901
Cdd:COG4785     81 VAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELA 160

                           90
                   ....*....|
gi 2030565369  902 QGYYEQLLEL 911
Cdd:COG4785    161 IADLEKALEL 170
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 539-645 8.15e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.28  E-value: 8.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  539 RALRDKKQYTRAEQIYTELLFdfRHPKQGSIEYAHMLCNE----LRKYEQAETTLRRQgLDHHPNDPDILSALgdVYLEW 614
Cdd:COG1729      1 KALLKAGDYDEAIAAFKAFLK--RYPNSPLAPDALYWLGEayyaLGDYDEAAEAFEKL-LKRYPDSPKAPDAL--LKLGL 75

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2030565369  615 AEEDPAQYEQARKTYQSLIASH-GTRDAYLAR 645
Cdd:COG1729     76 SYLELGDYDKARATLEELIKKYpDSEAAKEAR 107
Ebola_NP pfam05505
Ebola nucleoprotein; This family consists of Ebola and Marburg virus nucleoproteins. These ...
 29-249 8.45e-03

Ebola nucleoprotein; This family consists of Ebola and Marburg virus nucleoproteins. These proteins are responsible for encapsidation of genomic RNA. It has been found that nucleoprotein DNA vaccines can offer protection from the virus.


Pssm-ID: 398905  Cd Length: 717  Bit Score: 40.10  E-value: 8.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369   29 TLYDDLPPPESTPDGAQPAPTPERQSAPASASASGPVSAHGQrPFEPDTEASSVASGEEVVQEDAHAPQTRMHDSAQEPA 108
Cdd:pfam05505  474 DLEDTKPVPNRSTKGGQQKNSQKGQHIEGRQTQSRPIQNVPG-PHRTIHHASAPLTDNDRRNEPSGSTSPRMLTPINEEA 552

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  109 AEI--------------SLFSEERTPETMPTAAWSAPPDPLFETEHAVPPLPLDPEET-PVPGEKGLQESAVQEEDAGFN 173
Cdd:pfam05505  553 DPLddaddetsslppleSDDEEQDRDGTSNRTPTVAPPAPVYRDHSEKKELPQDEQQDqDHTQEARNQDSDNTQSEHSFE 632

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2030565369  174 QMPAtggQTSENQQHFDALLaSLDLDSANGERVVPENADEFAaqVPESLLEGLHPEDQETKRSQEE--PVSYDFPAFD 249
Cdd:pfam05505  633 EMYR---HILRSQGPFDAVL-YYHMMKDEPVVFSTSDGKEYT--YPDSLEEEYPPWLTEKEAMNEEnrFVTLDGQQFY 704
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 777-883 8.90e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.28  E-value: 8.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2030565369  777 LLEEKGHAAAREIFTQALTRYrsyivmrdlPPHRTIGKLYRDYADMdYFIYKNYDSALEHYQHARAQLLDT---PEVQYK 853
Cdd:COG1729      3 LLKAGDYDEAIAAFKAFLKRY---------PNSPLAPDALYWLGEA-YYALGDYDEAAEAFEKLLKRYPDSpkaPDALLK 72

                           90       100       110
                   ....*....|....*....|....*....|
gi 2030565369  854 IGYIQHKKNNYPEAIRAMNAAYEHNPQDKH 883
Cdd:COG1729     73 LGLSYLELGDYDKARATLEELIKKYPDSEA 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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