|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
1-241 |
4.10e-122 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 346.78 E-value: 4.10e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 1 MDANSLKDLIANHNNIVFFGGAGVSTESNIPDFRSSTGLFsqklnKQFTAEQLVSHTFFVRYPEEFFEFYKD--KLIYpN 78
Cdd:PRK00481 1 MRIEELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLW-----EEHRPEDVASPEGFARDPELVWKFYNErrRQLL-D 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 79 AKPNNAHIALAKLEEMGKLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLNLGGniPYCDNCGSIV 158
Cdd:PRK00481 75 AKPNAAHRALAELEKLGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEP--PRCPKCGGIL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 159 KPDVVLYEEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFID--YYKGDYIALINKANTVYDKSASLVINKPIGEV 236
Cdd:PRK00481 153 RPDVVLFGEMLPELAIDEAYEALEEADLFIVIGTSLVVYPAAGLPYeaREHGAKTVEINLEPTPLDSLFDLVIHGKAGEV 232
|
....*
gi 2053294596 237 LYEAV 241
Cdd:PRK00481 233 VPELV 237
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
1-237 |
2.45e-114 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 327.50 E-value: 2.45e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 1 MDA-NSLKDLIANHNNIVFFGGAGVSTESNIPDFRSSTGLFsqklnKQFTAEQLVSHTFFVRYPEEFFEFYKDKL-IYPN 78
Cdd:COG0846 1 MTKiERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLW-----EKYDPEEVASPEAFRRDPELVWAFYNERRrLLRD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 79 AKPNNAHIALAKLEEMGKLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLN--LGGNIPYCDNCGS 156
Cdd:COG0846 76 AEPNAAHRALAELEKAGKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVLEdlEGELPPRCPKCGG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 157 IVKPDVVLYEEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFIDYYK--GDYIALINKANTVYDKSASLVINKPIG 234
Cdd:COG0846 156 LLRPDVVWFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKraGAPLVEINPEPTPLDSLADLVIRGDAG 235
|
...
gi 2053294596 235 EVL 237
Cdd:COG0846 236 EVL 238
|
|
| SIR2H |
cd01411 |
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ... |
6-231 |
1.62e-104 |
|
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238702 Cd Length: 225 Bit Score: 301.98 E-value: 1.62e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 6 LKDLIANHNNIVFFGGAGVSTESNIPDFRSSTGLFSQKLnkQFTAEQLVSHTFFVRYPEEFFEFYKDKLIYPNAKPNNAH 85
Cdd:cd01411 1 LQHILKNAKRIVFFTGAGVSTASGIPDYRSKNGLYNEIY--KYSPEYLLSHDFLEREPEKFYQFVKENLYFPDAKPNIIH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 86 IALAKLEEMGkLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLNLggniPYCDNCGSIVKPDVVLY 165
Cdd:cd01411 79 QKMAELEKMG-LKAVITQNIDGLHQKAGSKNVVEFHGSLYRIYCTVCGKTVDWEEYLKS----PYHAKCGGVIRPDIVLY 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2053294596 166 EEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFIDYYK-GDYIALINKANTVYDKSASLVINK 231
Cdd:cd01411 154 EEMLNESVIEEAIQAIEKADLLVIVGTSFVVYPFAGLIDYRQaGANLIAINKEPTQLDSPATLVIKD 220
|
|
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
8-245 |
2.56e-86 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 256.35 E-value: 2.56e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 8 DLIANHNNIVFFGGAGVSTESNIPDFRSSTGLFsqklnKQFTAEQLVSHTFFVRYPEEFFEFYKDKL-IYPNAKPNNAHI 86
Cdd:NF040867 5 ELLASSRHAIAFTGAGISTESGIPTFRGPDGLW-----RRYDPEELATIEAFERDPKLVWEFYRWRMeKLFDAKPNPAHY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 87 ALAKLEEMGKLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLNL---GGNIPYCDNCGSIVKPDVV 163
Cdd:NF040867 80 ALAELERMGILKAVITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRTYDLEEVLRKidkGELPPRCPECGGLLRPDVV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 164 LYEEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFIDYYK--GDYIALINKANTVYDKSASLVINKPIGEVLyEAV 241
Cdd:NF040867 160 LFGEPLPDDALEEAFELAERSDVVLVVGSSLTVYPAAYLPYIAKenGGKLIIINPEETPLDPIADIVLRGRAGEVL-PKL 238
|
....
gi 2053294596 242 LRQI 245
Cdd:NF040867 239 VEEV 242
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
21-198 |
1.83e-67 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 205.95 E-value: 1.83e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 21 GAGVSTESNIPDFRSSTGLFSqKLNKQF--TAEQLVSHTFFVRYPEEFFEFYKDKLiYPNAKPNNAHIALAKLEEMGKLK 98
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYA-KLAPEElaSPEAFFSNPELVWDPEPFYNIARELL-PGEAQPNPAHYFIAKLEDKGKLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 99 AVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLN--LGGNIPYCDNCGSIVKPDVVLYEEALDsDVITK 176
Cdd:pfam02146 79 RLITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGETLYEriRPEKVPHCPQCGGLLKPDIVFFGENLP-DKFHR 157
|
170 180
....*....|....*....|..
gi 2053294596 177 TISAISNADLLIIGGTSLAVYP 198
Cdd:pfam02146 158 AYEDLEEADLLIVIGTSLKVYP 179
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
1-241 |
4.10e-122 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 346.78 E-value: 4.10e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 1 MDANSLKDLIANHNNIVFFGGAGVSTESNIPDFRSSTGLFsqklnKQFTAEQLVSHTFFVRYPEEFFEFYKD--KLIYpN 78
Cdd:PRK00481 1 MRIEELAEILDKAKRIVVLTGAGISAESGIPDFRSANGLW-----EEHRPEDVASPEGFARDPELVWKFYNErrRQLL-D 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 79 AKPNNAHIALAKLEEMGKLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLNLGGniPYCDNCGSIV 158
Cdd:PRK00481 75 AKPNAAHRALAELEKLGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEP--PRCPKCGGIL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 159 KPDVVLYEEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFID--YYKGDYIALINKANTVYDKSASLVINKPIGEV 236
Cdd:PRK00481 153 RPDVVLFGEMLPELAIDEAYEALEEADLFIVIGTSLVVYPAAGLPYeaREHGAKTVEINLEPTPLDSLFDLVIHGKAGEV 232
|
....*
gi 2053294596 237 LYEAV 241
Cdd:PRK00481 233 VPELV 237
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
1-237 |
2.45e-114 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 327.50 E-value: 2.45e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 1 MDA-NSLKDLIANHNNIVFFGGAGVSTESNIPDFRSSTGLFsqklnKQFTAEQLVSHTFFVRYPEEFFEFYKDKL-IYPN 78
Cdd:COG0846 1 MTKiERLAELLREAKRIVVLTGAGISAESGIPDFRGPDGLW-----EKYDPEEVASPEAFRRDPELVWAFYNERRrLLRD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 79 AKPNNAHIALAKLEEMGKLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLN--LGGNIPYCDNCGS 156
Cdd:COG0846 76 AEPNAAHRALAELEKAGKLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDVLEdlEGELPPRCPKCGG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 157 IVKPDVVLYEEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFIDYYK--GDYIALINKANTVYDKSASLVINKPIG 234
Cdd:COG0846 156 LLRPDVVWFGEMLPEEALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKraGAPLVEINPEPTPLDSLADLVIRGDAG 235
|
...
gi 2053294596 235 EVL 237
Cdd:COG0846 236 EVL 238
|
|
| SIR2H |
cd01411 |
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ... |
6-231 |
1.62e-104 |
|
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238702 Cd Length: 225 Bit Score: 301.98 E-value: 1.62e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 6 LKDLIANHNNIVFFGGAGVSTESNIPDFRSSTGLFSQKLnkQFTAEQLVSHTFFVRYPEEFFEFYKDKLIYPNAKPNNAH 85
Cdd:cd01411 1 LQHILKNAKRIVFFTGAGVSTASGIPDYRSKNGLYNEIY--KYSPEYLLSHDFLEREPEKFYQFVKENLYFPDAKPNIIH 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 86 IALAKLEEMGkLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLNLggniPYCDNCGSIVKPDVVLY 165
Cdd:cd01411 79 QKMAELEKMG-LKAVITQNIDGLHQKAGSKNVVEFHGSLYRIYCTVCGKTVDWEEYLKS----PYHAKCGGVIRPDIVLY 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2053294596 166 EEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFIDYYK-GDYIALINKANTVYDKSASLVINK 231
Cdd:cd01411 154 EEMLNESVIEEAIQAIEKADLLVIVGTSFVVYPFAGLIDYRQaGANLIAINKEPTQLDSPATLVIKD 220
|
|
| SIR2-fam |
cd01407 |
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ... |
14-230 |
4.21e-95 |
|
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.
Pssm-ID: 238698 Cd Length: 218 Bit Score: 277.53 E-value: 4.21e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 14 NNIVFFGGAGVSTESNIPDFRSSTGLFSqKLNKQftaEQLVSHTFFVRYPEEFFEFYKDKLIYPNAKPNNAHIALAKLEE 93
Cdd:cd01407 1 KRIVVLTGAGISTESGIPDFRSPGGLWA-RLDPE---ELAFSPEAFRRDPELFWGFYRERRYPLNAQPNPAHRALAELER 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 94 MGKLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLN--LGGNIPYCDNCGSIVKPDVVLYEEALDS 171
Cdd:cd01407 77 KGKLKRVITQNVDGLHQRAGSPKVIELHGSLFRVRCTKCGKEYPRDELQAdiDREEVPRCPKCGGLLRPDVVFFGESLPE 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2053294596 172 DvITKTISAISNADLLIIGGTSLAVYPAASFIDYYK--GDYIALINKANTVYDKSASLVIN 230
Cdd:cd01407 157 E-LDEAAEALAKADLLLVIGTSLQVYPAAGLPLYAPerGAPVVIINLEPTPADRKADLVIL 216
|
|
| prot_deacyl_CobB |
NF040867 |
NAD-dependent protein deacetylase; |
8-245 |
2.56e-86 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 468804 Cd Length: 242 Bit Score: 256.35 E-value: 2.56e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 8 DLIANHNNIVFFGGAGVSTESNIPDFRSSTGLFsqklnKQFTAEQLVSHTFFVRYPEEFFEFYKDKL-IYPNAKPNNAHI 86
Cdd:NF040867 5 ELLASSRHAIAFTGAGISTESGIPTFRGPDGLW-----RRYDPEELATIEAFERDPKLVWEFYRWRMeKLFDAKPNPAHY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 87 ALAKLEEMGKLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLNL---GGNIPYCDNCGSIVKPDVV 163
Cdd:NF040867 80 ALAELERMGILKAVITQNVDGLHQRAGSRNVIELHGNMRRVRCTSCGRTYDLEEVLRKidkGELPPRCPECGGLLRPDVV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 164 LYEEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFIDYYK--GDYIALINKANTVYDKSASLVINKPIGEVLyEAV 241
Cdd:NF040867 160 LFGEPLPDDALEEAFELAERSDVVLVVGSSLTVYPAAYLPYIAKenGGKLIIINPEETPLDPIADIVLRGRAGEVL-PKL 238
|
....
gi 2053294596 242 LRQI 245
Cdd:NF040867 239 VEEV 242
|
|
| SIR2_Af2 |
cd01413 |
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ... |
10-230 |
1.42e-84 |
|
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.
Pssm-ID: 238704 Cd Length: 222 Bit Score: 251.13 E-value: 1.42e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 10 IANHNNIVFFGGAGVSTESNIPDFRSSTGLFsqklnKQFTAEQLVSHTFFVRYPEEFFEFYKD-KLIYPNAKPNNAHIAL 88
Cdd:cd01413 1 LTKSRKTVVLTGAGISTESGIPDFRSPDGLW-----KKYDPEEVASIDYFYRNPEEFWRFYKEiILGLLEAQPNKAHYFL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 89 AKLEEMGKLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLNL-GGNIPYCDNCGSIVKPDVVLYEE 167
Cdd:cd01413 76 AELEKQGIIKAIITQNIDGLHQRAGSKNVIELHGTLQTAYCVNCGSKYDLEEVKYAkKHEVPRCPKCGGIIRPDVVLFGE 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2053294596 168 ALDSDVITKTISAISNADLLIIGGTSLAVYPAASFIDYYK--GDYIALINKANTVYDKSASLVIN 230
Cdd:cd01413 156 PLPQALLREAIEAAKEADLFIVLGSSLVVYPANLLPLIAKenGAKLVIVNADETPFDYIADLVIQ 220
|
|
| SIR2 |
cd00296 |
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ... |
14-229 |
1.77e-78 |
|
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.
Pssm-ID: 238184 [Multi-domain] Cd Length: 222 Bit Score: 235.70 E-value: 1.77e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 14 NNIVFFGGAGVSTESNIPDFRSS-TGLFSqKLNKQFTAEqlvSHTFFVRYPEEFFEFYKDKL-IYPNAKPNNAHIALAKL 91
Cdd:cd00296 1 KRVVVFTGAGISTESGIPDFRGLgTGLWT-RLDPEELAF---SPEAFRRDPELFWLFYKERRyTPLDAKPNPAHRALAEL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 92 EEMGKLKAVITQNIDGLHQMAGSK--NVLELHGSVHRNYCTKCGKFFDLESMLNLGGnIPYCDNCGSIVKPDVVLYEEAL 169
Cdd:cd00296 77 ERKGKLKRIITQNVDGLHERAGSRrnRVIELHGSLDRVRCTSCGKEYPRDEVLEREK-PPRCPKCGGLLRPDVVDFGEAL 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2053294596 170 DSDVITKTISAISNADLLIIGGTSLAVYPAASFIDYYK--GDYIALINKANTVYD--KSASLVI 229
Cdd:cd00296 156 PKEWFDRALEALLEADLVLVIGTSLTVYPAARLLLRAPerGAPVVIINREPTPADalKKADLVI 219
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
21-198 |
1.83e-67 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 205.95 E-value: 1.83e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 21 GAGVSTESNIPDFRSSTGLFSqKLNKQF--TAEQLVSHTFFVRYPEEFFEFYKDKLiYPNAKPNNAHIALAKLEEMGKLK 98
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYA-KLAPEElaSPEAFFSNPELVWDPEPFYNIARELL-PGEAQPNPAHYFIAKLEDKGKLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 99 AVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLN--LGGNIPYCDNCGSIVKPDVVLYEEALDsDVITK 176
Cdd:pfam02146 79 RLITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGETLYEriRPEKVPHCPQCGGLLKPDIVFFGENLP-DKFHR 157
|
170 180
....*....|....*....|..
gi 2053294596 177 TISAISNADLLIIGGTSLAVYP 198
Cdd:pfam02146 158 AYEDLEEADLLIVIGTSLKVYP 179
|
|
| SIRT5_Af1_CobB |
cd01412 |
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ... |
15-241 |
5.81e-63 |
|
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.
Pssm-ID: 238703 Cd Length: 224 Bit Score: 196.27 E-value: 5.81e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 15 NIVFFGGAGVSTESNIPDFRSSTGLFsqklnKQFTAEQLVSHTFFVRYPEEFFEFY--KDKLIYpNAKPNNAHIALAKLE 92
Cdd:cd01412 2 RVVVLTGAGISAESGIPTFRDADGLW-----ARFDPEELATPEAFARDPELVWEFYnwRRRKAL-RAQPNPAHLALAELE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 93 EMGKLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESmLNLGGNIPYCDNCGSIVKPDVVLYEEALDSD 172
Cdd:cd01412 76 RRLPNVLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGENNE-EIPEEELPRCPKCGGLLRPGVVWFGESLPLA 154
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2053294596 173 vITKTISAISNADLLIIGGTSLAVYPAASFIDYYK--GDYIALINKANTVYDKSASLVINKPIGEVLYEAV 241
Cdd:cd01412 155 -LLEAVEALAKADLFLVIGTSGVVYPAAGLPEEAKerGARVIEINPEPTPLSPIADFAFRGKAGEVLPALL 224
|
|
| PRK14138 |
PRK14138 |
NAD-dependent deacetylase; Provisional |
17-235 |
7.54e-62 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 172627 [Multi-domain] Cd Length: 244 Bit Score: 194.27 E-value: 7.54e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 17 VFFGGAGVSTESNIPDFRSSTGLFSQKLNKQFTAEqlvshtFFVRYPEEFFEFYKDKLI-YPNAKPNNAHIALAKLEEMG 95
Cdd:PRK14138 15 VTLTGAGISTPSGIPDFRGPQGIYKKYPQNVFDID------FFYSHPEEFYRFAKEGIFpMLEAKPNLAHVLLAKLEEKG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 96 KLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESMLNL--GGNIPYCDNCGSIVKPDVVLYEEALDSDV 173
Cdd:PRK14138 89 LIEAVITQNIDRLHQKAGSKKVIELHGNVEEYYCVRCGKRYTVEDVIEKleKSDVPRCDDCSGLIRPNIVFFGEALPQDA 168
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2053294596 174 ITKTISAISNADLLIIGGTSLAVYPAASF--IDYYKGDYIALINKANTVYDKSASLVINKPIGE 235
Cdd:PRK14138 169 LREAIRLSSKASLMIVMGSSLVVYPAAELplITVRSGGKLVIVNLGETPLDDIATLKYNMDVVE 232
|
|
| SIRT4 |
cd01409 |
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ... |
6-237 |
1.19e-53 |
|
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238700 Cd Length: 260 Bit Score: 173.64 E-value: 1.19e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 6 LKDLIANHNNIVFFGGAGVSTESNIPDFRSSTGLFSQKLnkqftaeQLVSHTFFVRYPEEFFEFYKDKLI-YP---NAKP 81
Cdd:cd01409 1 LQDFVARSRRLLVLTGAGISTESGIPDYRSEGGLYSRTF-------RPMTHQEFMRSPAARQRYWARSFVgWPrfsAAQP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 82 NNAHIALAKLEEMGKLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCG-----------------KFFDLESMLNL 144
Cdd:cd01409 74 NAAHRALAALEAAGRLHGLITQNVDGLHTKAGSRNVVELHGSLHRVVCLSCGfrtpraelqdrlealnpGFAEQAAGQAP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 145 GGN------------IPYCDNCGSIVKPDVVLYEEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFIDYY--KGDY 210
Cdd:cd01409 154 DGDvdledeqvagfrVPECERCGGVLKPDVVFFGENVPRDRVVTAAARLAEADALLVLGSSLMVYSGYRFVLAAaeAGLP 233
|
250 260
....*....|....*....|....*..
gi 2053294596 211 IALINKANTVYDKSASLVINKPIGEVL 237
Cdd:cd01409 234 IAIVNIGPTRADHLATLKVDARCGEVL 260
|
|
| SIRT1 |
cd01408 |
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ... |
15-204 |
1.31e-48 |
|
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.
Pssm-ID: 238699 Cd Length: 235 Bit Score: 159.72 E-value: 1.31e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 15 NIVFFGGAGVSTESNIPDFRSS-TGLFSqKLNKQF--TAEQLVSHTFFVRYPEEFFEFYKDklIYP-NAKPNNAHIALAK 90
Cdd:cd01408 2 KIVVLVGAGISTSAGIPDFRSPgTGLYA-NLARYNlpYPEAMFDISYFRKNPRPFYALAKE--LYPgQFKPSVAHYFIKL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 91 LEEMGKLKAVITQNIDGLHQMAG--SKNVLELHGSVHRNYCTKCGKFFDLESMLN--LGGNIPYCDNCGSIVKPDVVLYE 166
Cdd:cd01408 79 LEDKGLLLRNYTQNIDTLERVAGvpDDRIIEAHGSFATAHCIKCKHKYPGDWMREdiFNQEVPKCPRCGGLVKPDIVFFG 158
|
170 180 190
....*....|....*....|....*....|....*...
gi 2053294596 167 EALDSDVITKTISAISNADLLIIGGTSLAVYPAASFID 204
Cdd:cd01408 159 ESLPSRFFSHMEEDKEEADLLIVIGTSLKVAPFASLPS 196
|
|
| SIRT7 |
cd01410 |
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ... |
16-232 |
8.93e-48 |
|
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238701 Cd Length: 206 Bit Score: 156.69 E-value: 8.93e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 16 IVFFGGAGVSTESNIPDFRSSTGLFSQKLNKQftaEQLVSHTFFVRypeeffefykdkliypnAKPNNAHIALAKLEEMG 95
Cdd:cd01410 3 LVVFTGAGISTSAGIPDFRGPNGVWTLLPEDK---GRRRFSWRFRR-----------------AEPTLTHMALVELERAG 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 96 KLKAVITQNIDGLHQMAG--SKNVLELHGSVHRNYCTKCGKFF---DLESMLNLGGNIPYCDNCGSIVKPDVVLYEEALD 170
Cdd:cd01410 63 LLKFVISQNVDGLHLRSGlpREKLSELHGNMFIEVCKSCGPEYvrdDVVETRGDKETGRRCHACGGILKDTIVDFGERLP 142
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2053294596 171 SDVITKTISAISNADLLIIGGTSLAVYPAASFIDYYK--GDYIALINKANTVYDKSASLVINKP 232
Cdd:cd01410 143 PENWMGAAAAACRADLFLCLGTSLQVTPAANLPLKAAraGGRLVIVNLQPTPKDKLADLVIHGD 206
|
|
| PTZ00409 |
PTZ00409 |
Sir2 (Silent Information Regulator) protein; Provisional |
6-219 |
3.95e-42 |
|
Sir2 (Silent Information Regulator) protein; Provisional
Pssm-ID: 173599 [Multi-domain] Cd Length: 271 Bit Score: 144.29 E-value: 3.95e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 6 LKDLIANHNNIVFFGGAGVSTESNIPDFR-SSTGLFSQklnkqftAEQLVSHTF--FVRYPEEFFEFYKDKLIYPNAKPN 82
Cdd:PTZ00409 21 LADMIRKCKYVVALTGSGTSAESNIPSFRgPSSSIWSK-------YDPKIYGTIwgFWKYPEKIWEVIRDISSDYEIELN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 83 NAHIALAKLEEMGKLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDL-ESMLNLGGNI-----PYCDnCGS 156
Cdd:PTZ00409 94 PGHVALSTLESLGYLKFVVTQNVDGLHEESGNTKVIPLHGSVFEARCCTCRKTIQLnKIMLQKTSHFmhqlpPECP-CGG 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2053294596 157 IVKPDVVLYEEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFIDY--YKGDYIALINKANT 219
Cdd:PTZ00409 173 IFKPNVILFGEVIPKSLLKQAEKEIDKCDLLLVVGTSSSVSTATNLCYRahRKKKKIVEVNISKT 237
|
|
| PTZ00408 |
PTZ00408 |
NAD-dependent deacetylase; Provisional |
16-203 |
1.47e-41 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 240405 Cd Length: 242 Bit Score: 141.88 E-value: 1.47e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 16 IVFFGGAGVSTESNIPDFRSSTGLFsQKLNKQFTAEQLVshtfFVRYPEEFFEFYKDK---LIYPNAKPNNAHIALAKLE 92
Cdd:PTZ00408 7 ITILTGAGISAESGISTFRDGNGLW-ENHRVEDVATPDA----FLRNPALVQRFYNERrraLLSSSVKPNKAHFALAKLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 93 E--MGKLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFFDLESmlNLGGNIPYCDNCG--SIVKPDVVLY-EE 167
Cdd:PTZ00408 82 ReyRGGKVVVVTQNVDNLHERAGSTHVLHMHGELLKVRCTATGHVFDWTE--DVVHGSSRCKCCGcvGTLRPHIVWFgEM 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 2053294596 168 ALDSDVITktiSAISNADLLIIGGTSLAVYPAASFI 203
Cdd:PTZ00408 160 PLYMDEIE---SVMSKTDLFVAVGTSGNVYPAAGFV 192
|
|
| PRK05333 |
PRK05333 |
NAD-dependent protein deacetylase; |
2-243 |
8.42e-40 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 235415 Cd Length: 285 Bit Score: 138.66 E-value: 8.42e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 2 DANSLKDLIANHNNIVFFGGAGVSTESNIPDFRSSTGLFSQKLNKQFTAeQLVSHTFFVRYpeeffeFYKDKLIYP---N 78
Cdd:PRK05333 8 ALDALQDFVERHPRLFVLTGAGISTDSGIPDYRDRNGQWKRSPPITYQA-FMGSDAARRRY------WARSMVGWPvfgR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 79 AKPNNAHIALAKLEEMGKLKAVITQNIDGLHQMAGSKNVLELHGSVHRNYCTKCGKFF---------------------- 136
Cdd:PRK05333 81 AQPNAAHHALARLGAAGRIERLVTQNVDGLHQRAGSRDVIELHGRLDGVRCMGCGARHpraeiqhvleaanpewlaleaa 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 137 -------DLESMLNLGGNIPYCDNCGSIVKPDVVLYEEALDSDVITKTISAISNADLLIIGGTSLAVYPAASFIDYY--K 207
Cdd:PRK05333 161 papdgdaDLEWAAFDHFRVPACPACGGILKPDVVFFGENVPRERVAAARAALDAADAVLVVGSSLMVYSGYRFCVWAaqQ 240
|
250 260 270
....*....|....*....|....*....|....*.
gi 2053294596 208 GDYIALINKANTVYDKSASLVINKPIGEVLYEAVLR 243
Cdd:PRK05333 241 GKPIAALNLGRTRADPLLTLKVEASCAQALAALVAR 276
|
|
| PTZ00410 |
PTZ00410 |
NAD-dependent SIR2; Provisional |
12-200 |
1.23e-27 |
|
NAD-dependent SIR2; Provisional
Pssm-ID: 185600 Cd Length: 349 Bit Score: 108.03 E-value: 1.23e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 12 NHNNIVFFGGAGVSTESNIPDFRSS-TGLFSqKLNKQF--TAEQLVSHTFFVRYPEEFFEFYKDKLIYP-NAKPNNAHIA 87
Cdd:PTZ00410 28 NVTKILVMVGAGISVAAGIPDFRSPhTGIYA-KLGKYNlnSPTDAFSLTLLREKPEVFYSIAREMDLWPgHFQPTAVHHF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053294596 88 LAKLEEMGKLKAVITQNIDGLHQMAG-SKNVL-ELHGSVHRNYCTKCGKFFDLE--SMLNLGGNIPYCDNCGSIVKPDVV 163
Cdd:PTZ00410 107 IRLLADEGRLLRCCTQNIDGLERAAGvPPSLLvEAHGSFSAASCIECHTPYDIEqaYLEARSGKVPHCSTCGGIVKPDVV 186
|
170 180 190
....*....|....*....|....*....|....*..
gi 2053294596 164 LYEEALdSDVITKTISAISNADLLIIGGTSLAVYPAA 200
Cdd:PTZ00410 187 FFGENL-PDAFFNVHHDIPEAELLLIIGTSLQVHPFA 222
|
|
| |
