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Conserved domains on  [gi|2053416401|gb|QWS61231|]
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RidA family protein [Clostridioides difficile]

Protein Classification

RidA family protein( domain architecture ID 10794411)

RidA (reactive intermediate/imine deaminase A) family protein similar to 2-iminobutanoate/2-iminopropanoate deaminase, which catalyzes the deamination of enamine/imine intermediates to yield 2-ketobutyrate and ammonia

CATH:  3.30.1330.40
PubMed:  14624641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 4-126 1.30e-70

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


:

Pssm-ID: 129116  Cd Length: 124  Bit Score: 207.15  E-value: 1.30e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401   4 EVIHTNDAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVVEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDM 83
Cdd:TIGR00004   2 KIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTDL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2053416401  84 NEFGAINEVYAEYFGENKPARACVEVARLPKDVKVEIEVIAVL 126
Cdd:TIGR00004  82 NDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 4-126 1.30e-70

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 207.15  E-value: 1.30e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401   4 EVIHTNDAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVVEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDM 83
Cdd:TIGR00004   2 KIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTDL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2053416401  84 NEFGAINEVYAEYFGENKPARACVEVARLPKDVKVEIEVIAVL 126
Cdd:TIGR00004  82 NDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 1-126 3.91e-61

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 183.07  E-value: 3.91e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401   1 MKHEVIHTNdAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVvEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFI 80
Cdd:COG0251     1 MTRELINPP-APAPIGPYSQAVRVGNLVFVSGQVPLDPDTGEL-GGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2053416401  81 KDMNEFGAINEVYAEYFGENKPARACVEVARLPKDVKVEIEVIAVL 126
Cdd:COG0251    79 TDMADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAAL 124
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 10-125 3.55e-56

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 170.56  E-value: 3.55e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401  10 DAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVVEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDMNEFGAI 89
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2053416401  90 NEVYAEYFGENK-PARACVEVARLPKDVKVEIEVIAV 125
Cdd:pfam01042  81 NEVYAEYFDADKaPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 18-124 1.51e-50

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 155.79  E-value: 1.51e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401  18 YSQAIKAGNLLFVSGQVPLVPETmEVVEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDMNEFGAINEVYAEYF 97
Cdd:cd00448     1 YSQAVRVGNLVFVSGQIPLDPDG-ELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                          90       100
                  ....*....|....*....|....*...
gi 2053416401  98 GE-NKPARACVEVARLPKDVKVEIEVIA 124
Cdd:cd00448    80 GEgPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
4-125 4.21e-41

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 132.88  E-value: 4.21e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401   4 EVIHTNDAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVVEgDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDM 83
Cdd:PRK11401    3 KIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIPA-DVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2053416401  84 NEFGAINEVYAEYFGENK---PARACVEVARLPKDVKVEIEVIAV 125
Cdd:PRK11401   82 NDFATINEVYKQFFDEHQatyPTRSCVQVARLPKDVKLEIEAIAV 126
 
Name Accession Description Interval E-value
TIGR00004 TIGR00004
reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of ...
 4-126 1.30e-70

reactive intermediate/imine deaminase; This protein was described initially as an inhibitor of protein synthesis intiation, then as an endoribonuclease active on single-stranded mRNA, endoribonuclease L-PSP. Members of this family, conserved in all domains of life and often with several members per bacterial genome, appear to catalyze a reaction that minimizes toxic by-products from reactions catalyzed by pyridoxal phosphate-dependent enzymes. [Cellular processes, Other]


Pssm-ID: 129116  Cd Length: 124  Bit Score: 207.15  E-value: 1.30e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401   4 EVIHTNDAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVVEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDM 83
Cdd:TIGR00004   2 KIISTDKAPAAIGPYSQAVKVGNTVYVSGQIPLDPSTGELVGGDIAEQAEQVLENLKAILEAAGLSLDDVVKTTVFLTDL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 2053416401  84 NEFGAINEVYAEYFGENKPARACVEVARLPKDVKVEIEVIAVL 126
Cdd:TIGR00004  82 NDFAEVNEVYGQYFDEHYPARSAVQVAALPKGVLVEIEAIAVK 124
RidA COG0251
Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 ...
 1-126 3.91e-61

Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family [Defense mechanisms]; Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440021  Cd Length: 125  Bit Score: 183.07  E-value: 3.91e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401   1 MKHEVIHTNdAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVvEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFI 80
Cdd:COG0251     1 MTRELINPP-APAPIGPYSQAVRVGNLVFVSGQVPLDPDTGEL-GGDIEAQTRQVLENILAVLAAAGGSLDDVVKVTVYL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2053416401  81 KDMNEFGAINEVYAEYFGENKPARACVEVARLPKDVKVEIEVIAVL 126
Cdd:COG0251    79 TDMADFAAVNEVYAEYFGEGRPARTAVGVAALPKGALVEIEAIAAL 124
Ribonuc_L-PSP pfam01042
Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein ...
 10-125 3.55e-56

Endoribonuclease L-PSP; Endoribonuclease active on single-stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella.


Pssm-ID: 426010  Cd Length: 117  Bit Score: 170.56  E-value: 3.55e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401  10 DAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVVEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDMNEFGAI 89
Cdd:pfam01042   1 NAPAAAGPYSQAVKAGNLVYVSGQIPLDPDTGKLVEGDVAEQTRQVLENIKAVLAAAGASLSDVVKVTIFLADMNDFAEV 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2053416401  90 NEVYAEYFGENK-PARACVEVARLPKDVKVEIEVIAV 125
Cdd:pfam01042  81 NEVYAEYFDADKaPARSAVGVAALPLGALVEIEAIAV 117
YjgF_YER057c_UK114_family cd00448
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 18-124 1.51e-50

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100004 [Multi-domain]  Cd Length: 107  Bit Score: 155.79  E-value: 1.51e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401  18 YSQAIKAGNLLFVSGQVPLVPETmEVVEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDMNEFGAINEVYAEYF 97
Cdd:cd00448     1 YSQAVRVGNLVFVSGQIPLDPDG-ELVPGDIEAQTRQALENLEAVLEAAGGSLDDVVKVTVYLTDMADFAAVNEVYDEFF 79

                          90       100
                  ....*....|....*....|....*...
gi 2053416401  98 GE-NKPARACVEVARLPKDVKVEIEVIA 124
Cdd:cd00448    80 GEgPPPARTAVGVAALPPGALVEIEAIA 107
PRK11401 PRK11401
enamine/imine deaminase;
4-125 4.21e-41

enamine/imine deaminase;


Pssm-ID: 105214  Cd Length: 129  Bit Score: 132.88  E-value: 4.21e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401   4 EVIHTNDAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVVEgDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDM 83
Cdd:PRK11401    3 KIIETQRAPGAIGPYVQGVDLGSMVFTSGQIPVCPQTGEIPA-DVQDQARLSLENVKAIVVAAGLSVGDIIKMTVFITDL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2053416401  84 NEFGAINEVYAEYFGENK---PARACVEVARLPKDVKVEIEVIAV 125
Cdd:PRK11401   82 NDFATINEVYKQFFDEHQatyPTRSCVQVARLPKDVKLEIEAIAV 126
YjgF_YER057c_UK114_like_2 cd06150
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 18-125 2.51e-30

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100007  Cd Length: 105  Bit Score: 104.54  E-value: 2.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401  18 YSQAIKAGNLLFVSGQVPlvpetmEVVEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDMNEFGAINEVYAEYF 97
Cdd:cd06150     3 MSQAVVHNGTVYLAGQVA------DDTSADITGQTRQVLAKIDALLAEAGSDKSRILSATIWLADMADFAAMNAVWDAWV 76

                          90       100
                  ....*....|....*....|....*....
gi 2053416401  98 GE-NKPARACVEVARLPKDVKVEIEVIAV 125
Cdd:cd06150    77 PPgHAPARACVEAKLADPGYLVEIVVTAA 105
YjgF_YER057c_UK114_like_6 cd06154
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 18-124 5.93e-30

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100011  Cd Length: 119  Bit Score: 104.17  E-value: 5.93e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401  18 YSQAIKAGNLLFVSGQVPLVPETMeVVEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDMNEFGAINEVYAEYF 97
Cdd:cd06154    13 YSRAVRVGNWVFVSGTTGYDYDGM-VMPGDAYEQTRQCLEIIEAALAEAGASLEDVVRTRMYVTDIADFEAVGRAHGEVF 91

                          90       100
                  ....*....|....*....|....*...
gi 2053416401  98 GENKPARACVEVARLPKD-VKVEIEVIA 124
Cdd:cd06154    92 GDIRPAATMVVVSLLVDPeMLVEIEVTA 119
RutC TIGR03610
pyrimidine utilization protein C; This protein is observed in operons extremely similar to ...
 1-124 1.03e-25

pyrimidine utilization protein C; This protein is observed in operons extremely similar to that characterized in E. coli K-12 responsible for the import and catabolism of pyrimidines, primarily uracil. This protein is a member of the endoribonuclease L-PSP family defined by pfam01042.


Pssm-ID: 274677  Cd Length: 127  Bit Score: 93.76  E-value: 1.03e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401   1 MKHEVIHTNDAPAALGPYSQAIKAGNLLFVSGQVPLVPETMEVVEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFI 80
Cdd:TIGR03610   1 MPKKVIIPAGTSKPLAPFVPGTLADGVVYVSGTLPFDKDNNVVHVGDAAAQTRHVLETIKSVIETAGGTMDDVTFNHIFI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2053416401  81 KDMNEFGAINEVYAEYFGENKPARACVEVARLPKDVKVEIEVIA 124
Cdd:TIGR03610  81 RDWADYAAINEVYAEYFPGEKPARYCIQCGLVKPDALVEIASVA 124
YjgH_like cd02198
YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, ...
 18-126 5.24e-23

YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100005  Cd Length: 111  Bit Score: 86.16  E-value: 5.24e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401  18 YSQAIKAGNLLFVSGQVPLVPETmeVVEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDM-NEFGAINEVYAEY 96
Cdd:cd02198     3 YSPAVRVGDTLFVSGQVGSDADG--SVAEDFEAQFRLAFQNLGAVLEAAGCSFDDVVELTTFHVDMaAHLPAFAAVKDEY 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2053416401  97 FGENKPARACVEVARLPKD-VKVEIEVIAVL 126
Cdd:cd02198    81 FKEPYPAWTAVGVAWLARPgLLVEIKVVAVR 111
eu_AANH_C_1 cd06155
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 22-124 1.80e-22

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100012  Cd Length: 101  Bit Score: 84.62  E-value: 1.80e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401  22 IKAGNLLFVSGQVPLVPEtmevveGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFIKDMNEFGAINEVYAEYFGE-N 100
Cdd:cd06155     4 NRTGGLLWISNVTASESD------ETVEEQMESIFSKLREILQSNGLSLSDILYVTLYLRDMSDFAEVNSVYGTFFDKpN 77

                          90       100
                  ....*....|....*....|....
gi 2053416401 101 KPARACVEvARLPKDVKVEIEVIA 124
Cdd:cd06155    78 PPSRVCVE-CGLPEGCDVQLSCVA 100
eu_AANH_C_2 cd06156
A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine ...
 18-124 1.23e-18

A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these domains. The YjgF-YER057c-UK114 protein family is a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100013  Cd Length: 118  Bit Score: 75.06  E-value: 1.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401  18 YSQAIKAGNLLFVSGQVPLVPETMEVVEGDVQAQTAQSLKNLKAILAESGA-----------DFSNV-VKTTVFIKDMNE 85
Cdd:cd06156     1 YSQAIVVPKVAYISGQIGLIPATMTLLEGGITLQAVLSLQHLERVAKAMNVqwvlaavcyvtDESSVpIARSAWSKYCSE 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2053416401  86 FGAINEVYAEYFGENKPArACVEVARLPKDVKVEIEVIA 124
Cdd:cd06156    81 LDLEDESRNESDDVNPPL-VIVVVPELPRGALVEWQGIA 118
YjgF_YER057c_UK114_like_3 cd06151
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 27-124 2.67e-15

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100008  Cd Length: 126  Bit Score: 66.96  E-value: 2.67e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401  27 LLFVSGQVPLV-----PETMEVVEGDVQAQTAQSLKNLKAILAESGADFSNVVKTTVFI------KDMNEFGAINEVYAE 95
Cdd:cd06151    13 TIYLSGTVPAVvnasaPKGSPARYGDTETQTISVLKRIETILQSQGLTMGDVVKMRVFLvadpalDGKMDFAGFMKAYRQ 92

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2053416401  96 YFG----ENKPARACVEVARLPK-DVKVEIEVIA 124
Cdd:cd06151    93 FFGtaeqPNKPARSTLQVAGLVNpGWLVEIEVVA 126
YjgF_YER057c_UK114_like_1 cd02199
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 10-124 1.49e-14

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100006  Cd Length: 142  Bit Score: 65.17  E-value: 1.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401  10 DAPAALGPYSQAIKAGNLLFVSGQVPL----------VPETMEVVEGdvQAQTAQSLKNLKAILAESGADFS---NVVKT 76
Cdd:cd02199     8 PAPAPVGNYVPAVRTGNLLYVSGQLPRvdgklvytgkVGADLSVEEG--QEAARLCALNALAALKAALGDLDrvkRVVRL 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2053416401  77 TVFIKDMNEFGA----IN---EVYAEYFGEN-KPARACVEVARLPKDVKVEIEVIA 124
Cdd:cd02199    86 TGFVNSAPDFTEqpkvANgasDLLVEVFGEAgRHARSAVGVASLPLNAAVEVEAIV 141
YjgF_YER057c_UK114_like_4 cd06152
YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, ...
 18-125 1.39e-13

YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100009  Cd Length: 114  Bit Score: 61.94  E-value: 1.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401  18 YSQAIKAGNLLFVSGQVPLVPETMEVVEgDVQAQTAQSLKNL-KAILAESGADFSNVVKTTVF---IKDMNEFGAINEVY 93
Cdd:cd06152     3 YSQAVRIGDRIEISGQGGWDPDTGKIPE-DLEEEIDQAFDNVeLALKAAGGKGWEQVYKVNSYhvdIKNEEAFGLMVENF 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 2053416401  94 AEYFGENKPARACVEVARLP-KDVKVEIEVIAV 125
Cdd:cd06152    82 KKWMPNHQPIWTCVGVTALGlPGMRVEIEVDAI 114
YjgF_YER057c_UK114_like_5 cd06153
This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in ...
 21-124 1.72e-11

This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no functional connection. Members of this family have been implicated in isoleucine (Yeo7, Ibm1, aldR) and purine (YjgF) biosynthesis, as well as threonine anaerobic degradation (tdcF) and mitochondrial DNA maintenance (Ibm1). This domain homotrimerizes forming a distinct intersubunit cavity that may serve as a small molecule binding site.


Pssm-ID: 100010  Cd Length: 114  Bit Score: 56.50  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2053416401  21 AIKAGNLLFVSGQVPLVPETmEVVEGDVQAQTAQSLKNLKAILAE-----SGADFSNVVKTTVFIKDMNEFGAINEVYAE 95
Cdd:cd06153     8 AAGGRTHLFISGTASIVGHG-TVHPGDVEAQTRETLENIEALLEAagrggGAQFLADLLRLKVYLRDREDLPAVRAILAA 86

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2053416401  96 YFGENKPArACV--EVARlpKDVKVEIEVIA 124
Cdd:cd06153    87 RLGPAVPA-VFLqaDVCR--PDLLVEIEAVA 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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