FMRP translational regulator 1, partial [Rattus norvegicus]
Protein Classification
KH domain-containing protein( domain architecture ID 464)
KH (K homology) domain-containing protein binds single-stranded RNA or DNA
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| KH-I super family | cl00098 | K homology (KH) RNA-binding domain, type I; KH binds single-stranded RNA or DNA. It is found ... |
1-20 | 7.81e-09 | ||
K homology (KH) RNA-binding domain, type I; KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that belong to different protein folds, but they share a single KH motif. The KH motif is folded into a beta alpha alpha beta unit. In addition to the core, type II KH domains (e.g. ribosomal protein S3) include an N-terminal extension and type I KH domains (e.g. hnRNP K) contain a C-terminal extension. Some KH-I superfamily members contain a divergent KH domain that lacks the RNA-binding GXXG motif. Some others have a mutated GXXG motif which may or may not have nucleic acid binding ability. The actual alignment was detected with superfamily member cd22512: Pssm-ID: 469614 [Multi-domain] Cd Length: 78 Bit Score: 46.49 E-value: 7.81e-09
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| Name | Accession | Description | Interval | E-value | ||
| KH_I_FMR1_rpt3 | cd22512 | third type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein ... |
1-20 | 7.81e-09 | ||
third type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins; FMR1, also called FMRP, or synaptic functional regulator FMR1, is a multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. It also plays a role in the alternative splicing of its own mRNA. FMR1 contains three K-homology (KH) RNA-binding domains. The model corresponds to the third one. Pssm-ID: 411940 [Multi-domain] Cd Length: 78 Bit Score: 46.49 E-value: 7.81e-09
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| Name | Accession | Description | Interval | E-value | ||
| KH_I_FMR1_rpt3 | cd22512 | third type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein ... |
1-20 | 7.81e-09 | ||
third type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins; FMR1, also called FMRP, or synaptic functional regulator FMR1, is a multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. It also plays a role in the alternative splicing of its own mRNA. FMR1 contains three K-homology (KH) RNA-binding domains. The model corresponds to the third one. Pssm-ID: 411940 [Multi-domain] Cd Length: 78 Bit Score: 46.49 E-value: 7.81e-09
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| KH_I_FMR1_FXR_rpt3 | cd22427 | third type I K homology (KH) RNA-binding domain found in a family of fragile X mental ... |
1-20 | 2.62e-06 | ||
third type I K homology (KH) RNA-binding domain found in a family of fragile X mental retardation protein (FMR1) and fragile X related (FXR) proteins; The FMR1/FXR family includes FMR1 (also known as FMRP) and its two homologues, fragile X related 1 (FXR1) and 2 (FXR2). They are involved in translational regulation, particularly in neuronal cells and play an important role in the regulation of glutamate-mediated neuronal activity and plasticity. Each of these three proteins can form heteromers with the others, and each can also form homomers. Lack of expression of FMR1 results in mental retardation and macroorchidism. FXR1 and FXR2 may play important roles in the function of FMR1 and in the pathogenesis of the Fragile X Mental Retardation Syndrome. Members of this family contain three K-homology (KH) RNA-binding domains. The model corresponds to the third one. Pssm-ID: 411855 [Multi-domain] Cd Length: 79 Bit Score: 39.90 E-value: 2.62e-06
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| KH_I_FXR2_rpt3 | cd22511 | third type I K homology (KH) RNA-binding domain found in fragile X mental retardation ... |
1-20 | 5.75e-04 | ||
third type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins; FXR2, also known as FMR1L2, is an RNA-binding protein that plays a role in central nervous system function. It specifically regulates hippocampal neurogenesis by reducing the stability of Noggin mRNA. FXR2 contains three K-homology (KH) RNA-binding domains. The model corresponds to the third one. Pssm-ID: 411939 [Multi-domain] Cd Length: 78 Bit Score: 34.20 E-value: 5.75e-04
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| KH_I_FXR1_rpt3 | cd22510 | third type I K homology (KH) RNA-binding domain found in fragile X mental retardation ... |
1-20 | 7.72e-04 | ||
third type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 1 (FXR1) and similar proteins; FXR1 is an RNA-binding protein required for embryonic and postnatal development of muscle tissue. It may regulate intracellular transport and local translation of certain mRNAs. FXR1 protein may be present in amyloid form in brain of different species of mammals. It may regulate memory and emotions. FXR1 contains three K-homology (KH) RNA-binding domains. The model corresponds to the third one. Pssm-ID: 411938 [Multi-domain] Cd Length: 78 Bit Score: 33.79 E-value: 7.72e-04
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