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Conserved domains on  [gi|1417864322|gb|RAV62386|]
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hypothetical protein DBT35_07435 [Aerococcus mictus]

Protein Classification

PBP2_lipoprotein_MetQ_like domain-containing protein( domain architecture ID 10194207)

PBP2_lipoprotein_MetQ_like domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PBP2_lipoprotein_MetQ_like cd13526
The periplasmic-binding component of ABC-type methionine uptake transporter system and its ...
36-265 1.65e-95

The periplasmic-binding component of ABC-type methionine uptake transporter system and its related lipoproteins; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ) and its related homologs. Members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


:

Pssm-ID: 270244  Cd Length: 228  Bit Score: 280.35  E-value: 1.65e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322  36 KVVLGVSGQ-SAGMVKYVEQALNEKGYKLELSVAESTIASNEGLMDGSVDVNIMQHEAYMNQFNKDRGASLVKAGKPLFe 114
Cdd:cd13526     1 KLKIGVTAGpSADVVEAAKKEAKKKGYELELVVFTDYVAPNEALNDGSIDANFFQHVPFLDQFNKERNGDLVKVGKTVI- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322 115 QFIGVYSRKYKSLDELPDGAKVAIQNDASNIQRALRVLEQAKLIEVKQDIPKGETLtpLDVTSNPKNLEFVELGGGTLIE 194
Cdd:cd13526    80 APIGLYSKKYKSLDELPDGARIAIPNDPSNGARALLLLEDAGLIKLKDGVGLFATV--LDITENPKNLEIVEVDAAQLPR 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1417864322 195 SLDEVDIAVFCGLAANKAGFKTEDALYKFEPKDLKANALILATKDGNQDKEAVKIIHDAFESKESVELVKE 265
Cdd:cd13526   158 SLDDVDAAVINGNYAISAGLDPRKDAIFLEDSDASPYVNVLAVREDNKDDPWVKALVEAYQSEEVRKFLKE 228
 
Name Accession Description Interval E-value
PBP2_lipoprotein_MetQ_like cd13526
The periplasmic-binding component of ABC-type methionine uptake transporter system and its ...
36-265 1.65e-95

The periplasmic-binding component of ABC-type methionine uptake transporter system and its related lipoproteins; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ) and its related homologs. Members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270244  Cd Length: 228  Bit Score: 280.35  E-value: 1.65e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322  36 KVVLGVSGQ-SAGMVKYVEQALNEKGYKLELSVAESTIASNEGLMDGSVDVNIMQHEAYMNQFNKDRGASLVKAGKPLFe 114
Cdd:cd13526     1 KLKIGVTAGpSADVVEAAKKEAKKKGYELELVVFTDYVAPNEALNDGSIDANFFQHVPFLDQFNKERNGDLVKVGKTVI- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322 115 QFIGVYSRKYKSLDELPDGAKVAIQNDASNIQRALRVLEQAKLIEVKQDIPKGETLtpLDVTSNPKNLEFVELGGGTLIE 194
Cdd:cd13526    80 APIGLYSKKYKSLDELPDGARIAIPNDPSNGARALLLLEDAGLIKLKDGVGLFATV--LDITENPKNLEIVEVDAAQLPR 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1417864322 195 SLDEVDIAVFCGLAANKAGFKTEDALYKFEPKDLKANALILATKDGNQDKEAVKIIHDAFESKESVELVKE 265
Cdd:cd13526   158 SLDDVDAAVINGNYAISAGLDPRKDAIFLEDSDASPYVNVLAVREDNKDDPWVKALVEAYQSEEVRKFLKE 228
NlpA COG1464
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ...
8-273 1.17e-79

ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];


Pssm-ID: 441073 [Multi-domain]  Cd Length: 270  Bit Score: 241.55  E-value: 1.17e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322   8 MKKIVLSLVAIALVAA-----GFLYFSHQQEEKKVVLGVS-GQSAGMVKYVEQALNEKGYKLELSVAESTIASNEGLMDG 81
Cdd:COG1464     1 MKKLLALLLALALALAlaacgSSSAAAAAADKKTIKVGATpGPHAEILEVVKPELAKKGIDLEIVEFTDYVQPNEALADG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322  82 SVDVNIMQHEAYMNQFNKDRGASLVKAGKPLFEQfIGVYSRKYKSLDELPDGAKVAIQNDASNIQRALRVLEQAKLIEVK 161
Cdd:COG1464    81 EIDANYFQHIPYLDNFNKENGYDLVPVGKTHIEP-MGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLIKLK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322 162 QDIpkGETLTPLDVTSNPKNLEFVELGGGTLIESLDEVDIAVFCGLAANKAGFK-TEDALYkFEPKDlKANALILATKDG 240
Cdd:COG1464   160 DGV--GLLATVKDITENPKNLKFVELDAAQLPRSLDDVDAAVINGNYALEAGLDpTKDALF-LEDKD-SPYANIIVVRED 235
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1417864322 241 NQDKEAVKIIHDAFESKESVELVKEVSGGTWFP 273
Cdd:COG1464   236 DKDDPAIKKLVEAYQSDEVKKFIEEKYKGAVVP 268
Lipoprotein_9 pfam03180
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ...
37-269 4.51e-56

NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.


Pssm-ID: 427184  Cd Length: 236  Bit Score: 180.15  E-value: 4.51e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322  37 VVLGVS-GQSAGMVKYVEQALNEKGYKLELSVAESTIASNEGLMDGSVDVNIMQHEAYMNQFNKDRGASLVKAGKPLFEQ 115
Cdd:pfam03180   1 LKVGATpGPHAEILEVAKPLLKKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIEP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322 116 fIGVYSRKYKSLDELPDGAKVAIQNDASNIQRALRVLEQAKLIEVKQdiPKGETLTPLDVTSNPKNLEFVELGGGTLIES 195
Cdd:pfam03180  81 -MGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKD--GKGLLATVKDITENPKNLKIKELEAAQLPRA 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1417864322 196 LDEVDIAVFCGLAANKAGFKTEDALYKFEPKDlKANALILATKDGNQDKEAVKIIHDAFESKESVELVKEVSGG 269
Cdd:pfam03180 158 LDDVDAAVINTNYALEAGLNPKKDALFEEDKD-SPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGG 230
metQ PRK11063
D-methionine ABC transporter substrate-binding protein MetQ;
1-269 6.08e-38

D-methionine ABC transporter substrate-binding protein MetQ;


Pssm-ID: 182939 [Multi-domain]  Cd Length: 271  Bit Score: 134.50  E-value: 6.08e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322   1 MTFGGKSMKKIVLSLVAIALVAAGflyfshqQEEK---KVVLGVSGQSAGMVKYVEQALNEKGYKL--ELSVAESTIASN 75
Cdd:PRK11063    1 MAFKFKTFAAVGALIGTLALVGCG-------QDEKdpnHIKVGVIVGAEQQVAEVAQKVAKEKYGLdvELVTFNDYVLPN 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322  76 EGLMDGSVDVNIMQHEAYMNQFNKDRGASLVKAGKPlFEQFIGVYSRKYKSLDELPDGAKVAIQNDASNIQRALRVLEQA 155
Cdd:PRK11063   74 EALSKGDIDANAFQHKPYLDQQIKDRGYKLVAVGNT-FVYPIAGYSKKIKSLDELQDGSQVAVPNDPTNLGRSLLLLQKV 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322 156 KLIEVKQDIpkGETLTPLDVTSNPKNLEFVELGGGTLIESLDEVDIAVFC---------GLAANKAGFKTEDalykfepK 226
Cdd:PRK11063  153 GLIKLKDGV--GLLPTVLDIVENPKNLKIVELEAPQLPRSLDDAQIALAVinttyasqiGLTPAKDGIFVED-------K 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1417864322 227 DLKANALILATKDgNQDKEAVKIIHDAFESKESVELVKEVSGG 269
Cdd:PRK11063  224 DSPYVNLIVARED-NKDAENVKKFVQAYQSDEVYEAANKVFNG 265
 
Name Accession Description Interval E-value
PBP2_lipoprotein_MetQ_like cd13526
The periplasmic-binding component of ABC-type methionine uptake transporter system and its ...
36-265 1.65e-95

The periplasmic-binding component of ABC-type methionine uptake transporter system and its related lipoproteins; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ) and its related homologs. Members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270244  Cd Length: 228  Bit Score: 280.35  E-value: 1.65e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322  36 KVVLGVSGQ-SAGMVKYVEQALNEKGYKLELSVAESTIASNEGLMDGSVDVNIMQHEAYMNQFNKDRGASLVKAGKPLFe 114
Cdd:cd13526     1 KLKIGVTAGpSADVVEAAKKEAKKKGYELELVVFTDYVAPNEALNDGSIDANFFQHVPFLDQFNKERNGDLVKVGKTVI- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322 115 QFIGVYSRKYKSLDELPDGAKVAIQNDASNIQRALRVLEQAKLIEVKQDIPKGETLtpLDVTSNPKNLEFVELGGGTLIE 194
Cdd:cd13526    80 APIGLYSKKYKSLDELPDGARIAIPNDPSNGARALLLLEDAGLIKLKDGVGLFATV--LDITENPKNLEIVEVDAAQLPR 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1417864322 195 SLDEVDIAVFCGLAANKAGFKTEDALYKFEPKDLKANALILATKDGNQDKEAVKIIHDAFESKESVELVKE 265
Cdd:cd13526   158 SLDDVDAAVINGNYAISAGLDPRKDAIFLEDSDASPYVNVLAVREDNKDDPWVKALVEAYQSEEVRKFLKE 228
NlpA COG1464
ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion ...
8-273 1.17e-79

ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism];


Pssm-ID: 441073 [Multi-domain]  Cd Length: 270  Bit Score: 241.55  E-value: 1.17e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322   8 MKKIVLSLVAIALVAA-----GFLYFSHQQEEKKVVLGVS-GQSAGMVKYVEQALNEKGYKLELSVAESTIASNEGLMDG 81
Cdd:COG1464     1 MKKLLALLLALALALAlaacgSSSAAAAAADKKTIKVGATpGPHAEILEVVKPELAKKGIDLEIVEFTDYVQPNEALADG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322  82 SVDVNIMQHEAYMNQFNKDRGASLVKAGKPLFEQfIGVYSRKYKSLDELPDGAKVAIQNDASNIQRALRVLEQAKLIEVK 161
Cdd:COG1464    81 EIDANYFQHIPYLDNFNKENGYDLVPVGKTHIEP-MGLYSKKYKSLDELPDGATIAIPNDPTNQGRALLLLQKAGLIKLK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322 162 QDIpkGETLTPLDVTSNPKNLEFVELGGGTLIESLDEVDIAVFCGLAANKAGFK-TEDALYkFEPKDlKANALILATKDG 240
Cdd:COG1464   160 DGV--GLLATVKDITENPKNLKFVELDAAQLPRSLDDVDAAVINGNYALEAGLDpTKDALF-LEDKD-SPYANIIVVRED 235
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1417864322 241 NQDKEAVKIIHDAFESKESVELVKEVSGGTWFP 273
Cdd:COG1464   236 DKDDPAIKKLVEAYQSDEVKKFIEEKYKGAVVP 268
Lipoprotein_9 pfam03180
NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. ...
37-269 4.51e-56

NlpA lipoprotein; This entry represents bacterial lipoproteins that belong to the NlpA family. It contains several antigenic members, that may be involved in bacterial virulence. This entry includes the D-methionine binding lipoprotein MetQ, which is the substrate-binding component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Other members of this family, such as NlpA, have been identified as putative substrate-binding components of ABC transporters. NlpA, is an inner-membrane-anchored lipoprotein that has been shown to have a minor role in methionine import.


Pssm-ID: 427184  Cd Length: 236  Bit Score: 180.15  E-value: 4.51e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322  37 VVLGVS-GQSAGMVKYVEQALNEKGYKLELSVAESTIASNEGLMDGSVDVNIMQHEAYMNQFNKDRGASLVKAGKPLFEQ 115
Cdd:pfam03180   1 LKVGATpGPHAEILEVAKPLLKKKGLDLEIVEFTDYVQPNTALADGEIDANYFQHLPYLDQFNKEKGLDLVAVGNVHIEP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322 116 fIGVYSRKYKSLDELPDGAKVAIQNDASNIQRALRVLEQAKLIEVKQdiPKGETLTPLDVTSNPKNLEFVELGGGTLIES 195
Cdd:pfam03180  81 -MGLYSKKYKSLSELPDGATIAVPNDPSNEGRALLLLQKAGLIKLKD--GKGLLATVKDITENPKNLKIKELEAAQLPRA 157
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1417864322 196 LDEVDIAVFCGLAANKAGFKTEDALYKFEPKDlKANALILATKDGNQDKEAVKIIHDAFESKESVELVKEVSGG 269
Cdd:pfam03180 158 LDDVDAAVINTNYALEAGLNPKKDALFEEDKD-SPYVNIIVVREDDKDDEAVKKLVEAYQSEEVKKFIEKKYGG 230
PBP2_lipoprotein_like_1 cd13600
Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; ...
38-265 6.54e-54

Putative periplasmic-binding component of ABC-type methionine uptake transporter system-like; the type 2 periplasmic binding protein fold; This subgroup shares significant sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270318  Cd Length: 228  Bit Score: 174.45  E-value: 6.54e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322  38 VLGVSGQSAGM---VKYVEQALNEKGYKLELSVAESTIASNEGLMDGSVDVNIMQHEAYMNQFNKDRGASLVKAgKPLFE 114
Cdd:cd13600     1 TLKVATNSGPMteiLEYIAAELAPDGITIEPVQVSDYVQANRAVAAGEIDANFFQHQPFMEQFNEANGFELVAV-QPIYH 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322 115 QFIGVYSRKYKSLDELPDGAKVAIQNDASNIQRALRVLEQAKLIEVKQDIPKGETLTPlDVTSNPKNLEFVELGGGTLIE 194
Cdd:cd13600    80 WAFGFYSKKYKSVEDLPDGAKVAIPNDPANQARALLLLQRAGLITLKPGVDPTTATLA-DIVTNPKNLKFTEVDLLALPR 158
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1417864322 195 SLDEVDIAVFCGLAANKAGFKTEDALYkFEPKDLKANALILATKDGNQDKEAVKIIHDAFESKESVELVKE 265
Cdd:cd13600   159 ALDDVDLAFGYPSYFDAAGLTPKDGIL-LEEPDAKRFAIQLVAREDNKDSPKIKKLKEAFTDPRVRKFLET 228
PBP2_lipoprotein_Gna1946 cd13599
The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 ...
36-258 9.28e-44

The membrane-associated lipoprotein Gna1946 from Neisseria meningitidis; the type 2 periplasmic binding protein fold; Gna1946 shares significant structural and sequence homology with the periplasmic substrate-binding domain of ATP-binding cassette (ABC) transporter involved in uptake of methionine (MetQ). The members of the MetQ-like family include the 32-kilodalton lipoprotein (Tp32) from Treponema pallidum, the membrane-associated lipoprotein-9 GmpC from Staphylococcus aureus, and Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus. They all function as a receptor for methionine. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270317  Cd Length: 228  Bit Score: 148.31  E-value: 9.28e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322  36 KVVLGVS-GQSAGMVKY-VEQALNEKGYKLELSVAESTIASNEGLMDGSVDVNIMQHEAYMNQFNKDRGASLVKAGK--- 110
Cdd:cd13599     1 TIVIGFTpGPYGDMVKNgVAPYLEKKGYEVKLKEFTDYVQPNNALANGEIDANVFQHKPYLDAFNKENGLDLVGIVQvpt 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322 111 -PLfeqfiGVYSRKYKSLDELPDGAKVAIQNDASNIQRALRVLEQAKLIEVKQDIpKGETLTPLDVTSNPKNLEFVELGG 189
Cdd:cd13599    81 pPM-----GLYSNKHKSLEEVKDGATVAIPNDPSNLARALVMLQDLGWITLKDNI-DPLKASVNDIAENPKNIKIVELEA 154
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1417864322 190 GTLIESLDEVDIAVFCGLAANKAGFKTEDALYKFEPKDLKANALILATKdgNQDKEAVKIIHDAFESKE 258
Cdd:cd13599   155 AQLPRSLDDVDFAAIQGNFAISSGIKLTSALALEEMTDPYVNVVAVKTA--DKDKQFAKDVTAAYNSDA 221
PBP2_lipoprotein_IlpA_like cd13598
Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar ...
36-258 3.42e-43

Toll-like receptor 2-activating lipoprotein IlpA from Vibrio vulnificus and similar lipoproteins; the type 2 periplasmic binding protein fold; This group includes the IlpA protein which has both structural and sequential homology to the MetQ family of substrate-binding protein, and thus belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. The majority of PBP2 proteins function in the uptake of small soluble substrates in eubacteria and archaea.


Pssm-ID: 270316  Cd Length: 227  Bit Score: 146.73  E-value: 3.42e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322  36 KVVLGV-SGQSAGMVKYVEQALNEKGYKLELSVAESTIASNEGLMDGSVDVNIMQHEAYMNQFNKDRGASLVKAGKPlFE 114
Cdd:cd13598     1 PIKVGViRGPDAQIWEVVQKVAKEKGLDVELVTFNDYAQPNEALAAGDLDANAFQHKPYLDAQIKARGYKLVIVGNT-FV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322 115 QFIGVYSRKYKSLDELPDGAKVAIQNDASNIQRALRVLEQAKLIEVKQDIpkGETLTPLDVTSNPKNLEFVELGGGTLIE 194
Cdd:cd13598    80 YPIGLYSKKIKSLAELPNGATVAIPNDPSNEGRALLLLQKEGLIKLKDGV--GLLATVRDIAENPKKLKIVELDAGQLPR 157
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1417864322 195 SLDEVDIAVFCGLAANKAGFK-TEDALykFEPKDLKANALILATKDGNQDKEAVKIIHDAFESKE 258
Cdd:cd13598   158 ALDDVDLAAINTDYASKAGLTpARDAI--AQEDKRSPYANVIAVREDDKDAPWVKTLVQAYQSEE 220
metQ PRK11063
D-methionine ABC transporter substrate-binding protein MetQ;
1-269 6.08e-38

D-methionine ABC transporter substrate-binding protein MetQ;


Pssm-ID: 182939 [Multi-domain]  Cd Length: 271  Bit Score: 134.50  E-value: 6.08e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322   1 MTFGGKSMKKIVLSLVAIALVAAGflyfshqQEEK---KVVLGVSGQSAGMVKYVEQALNEKGYKL--ELSVAESTIASN 75
Cdd:PRK11063    1 MAFKFKTFAAVGALIGTLALVGCG-------QDEKdpnHIKVGVIVGAEQQVAEVAQKVAKEKYGLdvELVTFNDYVLPN 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322  76 EGLMDGSVDVNIMQHEAYMNQFNKDRGASLVKAGKPlFEQFIGVYSRKYKSLDELPDGAKVAIQNDASNIQRALRVLEQA 155
Cdd:PRK11063   74 EALSKGDIDANAFQHKPYLDQQIKDRGYKLVAVGNT-FVYPIAGYSKKIKSLDELQDGSQVAVPNDPTNLGRSLLLLQKV 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322 156 KLIEVKQDIpkGETLTPLDVTSNPKNLEFVELGGGTLIESLDEVDIAVFC---------GLAANKAGFKTEDalykfepK 226
Cdd:PRK11063  153 GLIKLKDGV--GLLPTVLDIVENPKNLKIVELEAPQLPRSLDDAQIALAVinttyasqiGLTPAKDGIFVED-------K 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1417864322 227 DLKANALILATKDgNQDKEAVKIIHDAFESKESVELVKEVSGG 269
Cdd:PRK11063  224 DSPYVNLIVARED-NKDAENVKKFVQAYQSDEVYEAANKVFNG 265
PRK09861 PRK09861
lipoprotein NlpA;
8-273 4.63e-36

lipoprotein NlpA;


Pssm-ID: 182119  Cd Length: 272  Bit Score: 129.76  E-value: 4.63e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322   8 MKKIVLSL-VAIALVAAGFLYFSHQQ---EEKKVVLGV-SGQSAGMVKYVEQALNEK-GYKLELSVAESTIASNEGLMDG 81
Cdd:PRK09861    1 MKLTTHHLrAGAALLLAGILLAGCDQsssDAKHIKVGViNGAEQDVAEVAKKVAKEKyGLDVELVGFSGSLLPNDATNHG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322  82 SVDVNIMQHEAYMNQFNKDRGASLVKAGKPLFEQFIGvYSRKYKSLDELPDGAKVAIQNDASNIQRALRVLEQAKLIEVK 161
Cdd:PRK09861   81 ELDANVFQHRPFLEQDNQAHGYKLVAVGNTFVFPMAG-YSKKIKTVAQIKEGATVAIPNDPTNLGRALLLLQKEKLITLK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1417864322 162 QDipKGETLTPLDVTSNPKNLEFVELGGGTLIESLDE--VDIAVFCGLAANKAGFK-TEDALYKFEPKDLKANalILATK 238
Cdd:PRK09861  160 EG--KGLLPTALDITDNPRHLQIMELEGAQLPRVLDDpkVDVAIISTTYIQQTGLSpVHDSVFIEDKNSPYVN--ILVAR 235
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1417864322 239 DGNQDKEAVKIIHDAFESKESVELVKEVSGGTWFP 273
Cdd:PRK09861  236 EDNKNAENVKEFLQSYQSPEVAKAAETIFNGGAVP 270
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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