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Conserved domains on  [gi|1420787656|gb|RBL73485|]
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AraC family transcriptional regulator [Pseudomonas sp. MWU13-2625]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 14398448)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  2.60.120.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  11282467|33837749|9409145|12270809|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 18-112 3.33e-29

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


:

Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 106.12  E-value: 3.33e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656  18 VYFRYADFNAHEYAAPHLHPWGTLEYAAHGVLHMDVDGSRFMSPPHYAVWVPPQVEHSFYSHQPVNYRAVCLDPKVCADL 97
Cdd:cd06124     1 VLARAADYPAGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAAGL 80

                          90
                  ....*....|....*
gi 1420787656  98 PPRACTLAISDILKA 112
Cdd:cd06124    81 PAEPCVLAVSPLLRE 95
HTH_18 pfam12833
Helix-turn-helix domain;
179-257 1.34e-27

Helix-turn-helix domain;


:

Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 101.51  E-value: 1.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 179 WAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEAL--ESTRSVQEIAFDLGYSSGSAFIAMFARQAGCTPEQYRR 256
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLleDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1420787656 257 S 257
Cdd:pfam12833  81 R 81
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 18-112 3.33e-29

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 106.12  E-value: 3.33e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656  18 VYFRYADFNAHEYAAPHLHPWGTLEYAAHGVLHMDVDGSRFMSPPHYAVWVPPQVEHSFYSHQPVNYRAVCLDPKVCADL 97
Cdd:cd06124     1 VLARAADYPAGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAAGL 80

                          90
                  ....*....|....*
gi 1420787656  98 PPRACTLAISDILKA 112
Cdd:cd06124    81 PAEPCVLAVSPLLRE 95
HTH_18 pfam12833
Helix-turn-helix domain;
179-257 1.34e-27

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 101.51  E-value: 1.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 179 WAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEAL--ESTRSVQEIAFDLGYSSGSAFIAMFARQAGCTPEQYRR 256
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLleDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1420787656 257 S 257
Cdd:pfam12833  81 R 81
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
1-258 1.10e-25

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 101.78  E-value: 1.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656   1 MNSKHIDLLDFSELPSAVYFRYADFNAHEYAAPHLHPWGTLEYAAHGVLHMDVDGSRFMSPPHYAVWVPPQVEHSFYSHQ 80
Cdd:COG2207     2 RLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656  81 PVNYRAVCLDPKVCADLPPRACTLAISDILKAILKDFAARDVKIPELDADQRLAQVLVDQLQQAPVHECYLPYARNPGLL 160
Cdd:COG2207    82 LLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 161 AILNALQADpgnnqpLAHWAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEALEST-RSVQEIAFDLGYSSGSAF 239
Cdd:COG2207   162 LLLLLLLLT------LEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHF 235

                         250
                  ....*....|....*....
gi 1420787656 240 IAMFARQAGCTPEQYRRSH 258
Cdd:COG2207   236 SRAFKKRFGVTPSEYRKRL 254
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 154-258 1.64e-23

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 96.77  E-value: 1.64e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 154 ARNPGLLAILNALQADPGNNQPLAHWAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEALESTR-SVQEIAFDLG 232
Cdd:COG4977   207 HRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDlSIEEIAAACG 286

                          90       100
                  ....*....|....*....|....*.
gi 1420787656 233 YSSGSAFIAMFARQAGCTPEQYRRSH 258
Cdd:COG4977   287 FGSASHFRRAFRRRFGVSPSAYRRRF 312
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
179-255 6.44e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.84  E-value: 6.44e-22
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1420787656  179 WAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEALEST-RSVQEIAFDLGYSSGSAFIAMFARQAGCTPEQYR 255
Cdd:smart00342   7 LAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEYR 84
ftrA PRK09393
transcriptional activator FtrA; Provisional
 132-257 2.88e-13

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 68.45  E-value: 2.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 132 RLAQVLV-------DQLQQAPVhecylPYARNPG--LLAILNALQADPGNNQPLAHWAAQVHVSERTLARQFVRELGMSF 202
Cdd:PRK09393  189 RVARRLVvpphrdgGQAQFVPR-----PVASRESdrLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTP 263

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1420787656 203 GEWRQRLRYLAAIEALESTR-SVQEIAFDLGYSSGSAFIAMFARQAGCTPEQYRRS 257
Cdd:PRK09393  264 AEWLLRERLARARDLLESSAlSIDQIAERAGFGSEESLRHHFRRRAATSPAAYRKR 319
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 18-112 3.33e-29

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 106.12  E-value: 3.33e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656  18 VYFRYADFNAHEYAAPHLHPWGTLEYAAHGVLHMDVDGSRFMSPPHYAVWVPPQVEHSFYSHQPVNYRAVCLDPKVCADL 97
Cdd:cd06124     1 VLARAADYPAGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAAGL 80

                          90
                  ....*....|....*
gi 1420787656  98 PPRACTLAISDILKA 112
Cdd:cd06124    81 PAEPCVLAVSPLLRE 95
HTH_18 pfam12833
Helix-turn-helix domain;
179-257 1.34e-27

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 101.51  E-value: 1.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 179 WAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEAL--ESTRSVQEIAFDLGYSSGSAFIAMFARQAGCTPEQYRR 256
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLleDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1420787656 257 S 257
Cdd:pfam12833  81 R 81
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
1-258 1.10e-25

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 101.78  E-value: 1.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656   1 MNSKHIDLLDFSELPSAVYFRYADFNAHEYAAPHLHPWGTLEYAAHGVLHMDVDGSRFMSPPHYAVWVPPQVEHSFYSHQ 80
Cdd:COG2207     2 RLLILLLLLLLLLALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656  81 PVNYRAVCLDPKVCADLPPRACTLAISDILKAILKDFAARDVKIPELDADQRLAQVLVDQLQQAPVHECYLPYARNPGLL 160
Cdd:COG2207    82 LLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 161 AILNALQADpgnnqpLAHWAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEALEST-RSVQEIAFDLGYSSGSAF 239
Cdd:COG2207   162 LLLLLLLLT------LEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHF 235

                         250
                  ....*....|....*....
gi 1420787656 240 IAMFARQAGCTPEQYRRSH 258
Cdd:COG2207   236 SRAFKKRFGVTPSEYRKRL 254
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 154-258 1.64e-23

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 96.77  E-value: 1.64e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 154 ARNPGLLAILNALQADPGNNQPLAHWAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEALESTR-SVQEIAFDLG 232
Cdd:COG4977   207 HRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDlSIEEIAAACG 286

                          90       100
                  ....*....|....*....|....*.
gi 1420787656 233 YSSGSAFIAMFARQAGCTPEQYRRSH 258
Cdd:COG4977   287 FGSASHFRRAFRRRFGVSPSAYRRRF 312
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
179-255 6.44e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.84  E-value: 6.44e-22
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1420787656  179 WAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEALEST-RSVQEIAFDLGYSSGSAFIAMFARQAGCTPEQYR 255
Cdd:smart00342   7 LAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSEYR 84
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 161-258 6.68e-19

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 84.72  E-value: 6.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 161 AILNALQADPGNNQPLAHWAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEALESTRSVQEIAFDLGYSSGSAFI 240
Cdd:COG2169    88 RACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVTDAAYAAGFGSLSRFY 167

                          90
                  ....*....|....*...
gi 1420787656 241 AMFARQAGCTPEQYRRSH 258
Cdd:COG2169   168 EAFKKLLGMTPSAYRRGG 185
ftrA PRK09393
transcriptional activator FtrA; Provisional
 132-257 2.88e-13

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 68.45  E-value: 2.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 132 RLAQVLV-------DQLQQAPVhecylPYARNPG--LLAILNALQADPGNNQPLAHWAAQVHVSERTLARQFVRELGMSF 202
Cdd:PRK09393  189 RVARRLVvpphrdgGQAQFVPR-----PVASRESdrLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTP 263

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1420787656 203 GEWRQRLRYLAAIEALESTR-SVQEIAFDLGYSSGSAFIAMFARQAGCTPEQYRRS 257
Cdd:PRK09393  264 AEWLLRERLARARDLLESSAlSIDQIAERAGFGSEESLRHHFRRRAATSPAAYRKR 319
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
162-256 8.44e-10

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 57.99  E-value: 8.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 162 ILNALQADPGNNQPLAHWAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEALESTRS-VQEIAFDLGYSSGSAFI 240
Cdd:PRK13501  181 IMSALQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHrISDIAARCGFEDSNYFS 260

                          90
                  ....*....|....*.
gi 1420787656 241 AMFARQAGCTPEQYRR 256
Cdd:PRK13501  261 AVFTREAGMTPRDYRQ 276
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
176-264 1.93e-07

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 50.82  E-value: 1.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 176 LAHWAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEALESTR-SVQEIAFDLGYSSGSAFIAMFARQAGCTPEQY 254
Cdd:PRK13502  195 LDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPlMISEISMQCGFEDSNYFSVVFTRETGMTPSQW 274

                          90
                  ....*....|
gi 1420787656 255 RrsHLEGRKV 264
Cdd:PRK13502  275 R--HLSNQSD 282
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
180-257 1.13e-06

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 46.07  E-value: 1.13e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1420787656 180 AAQVHVSERTLARQFVRELGMSFGEW-RQRLRYLAAIEALESTRSVQEIAFDLGYSSGSAFIAMFARQAGCTPEQYRRS 257
Cdd:PRK10219   28 AKKSGYSKWYLQRMFRTVTHQTLGDYiRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQTFSRVFRRQFDRTPSDYRHR 106
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
176-263 6.30e-06

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 46.63  E-value: 6.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 176 LAHWAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEALESTRS-VQEIAFDLGYSSGSAFIAMFARQAGCTPEQY 254
Cdd:PRK13500  225 LDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLlISDISTECGFEDSNYFSVVFTRETGMTPSQW 304


                  ....*....
gi 1420787656 255 RrsHLEGRK 263
Cdd:PRK13500  305 R--HLNSQK 311
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 177-259 1.61e-05

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 45.41  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 177 AHWAAQVHVSERTLARQFVRElGMSFGEWRQRLRYLAAIEALEST---RSVQEIAFDLGYSSGSAFIAMFARQAGCTPEQ 253
Cdd:PRK09685  218 EWIAGELGISVRSLYRLFAEQ-GLVVAQYIRNRRLDRCADDLRPAaddEKITSIAYKWGFSDSSHFSTAFKQRFGVSPGE 296


                  ....*.
gi 1420787656 254 YRRSHL 259
Cdd:PRK09685  297 YRRKFR 302
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
162-260 1.82e-05

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 44.96  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 162 ILNALQADPGNNQP----------------------LAHWAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEALE 219
Cdd:PRK10572  166 LLRCMEAIPESLHPpmdprvreacqyisdhlasefdIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQ 245

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1420787656 220 STR-SVQEIAFDLGYSSGSAFIAMFARQAGCTPEQYRRSHLE 260
Cdd:PRK10572  246 TTRmPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRARCEE 287
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 162-257 1.46e-04

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 42.29  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 162 ILNALQADPGNNQPLAHWAAQVHVSERTLARQFVRElGMSFGEWRQRLRYLAAIEALESTR-SVQEIAFDLGYSSGSAFI 240
Cdd:PRK15185  211 VYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAEE-GTSFSDIYLSARMNQAAKLLRIGNhNVNAVALKCGYDSTSYFI 289

                          90
                  ....*....|....*..
gi 1420787656 241 AMFARQAGCTPEQYRRS 257
Cdd:PRK15185  290 QCFKKYFKTTPSTFIKM 306
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
 218-257 2.20e-04

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 41.67  E-value: 2.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1420787656 218 LESTR-SVQEIAFDLGYSSGSAFIAMFARQAGCTPEQYRRS 257
Cdd:PRK10296  233 LEMTNySVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYRKK 273
cupin_BacB_N cd20307
Bacillus subtilis bacilysin and related proteins, N-terminal cupin domain; This model ...
 31-92 3.52e-04

Bacillus subtilis bacilysin and related proteins, N-terminal cupin domain; This model represents the N-terminal domain of bacilysin (BacB, also known as AerE in Microcystis aeruginosa), a non-ribosomally synthesized dipeptide antibiotic that is produced and excreted by certain strains of Bacillus subtilis. Bacilysin is an oxidase that catalyzes the synthesis of 2-oxo-3-(4-oxocyclohexa-2,5-dienyl)propanoic acid, a precursor to L-anticapsin. Each bacilysin monomer has two tandem cupin domains. It is active against a wide range of bacteria and some fungi. The antimicrobial activity of bacilysin is antagonized by glucosamine and N-acetyl glucosamine, indicating that bacilysin interferes with glucosamine synthesis, and thus, with the synthesis of microbial cell walls. AerE is thought to be involved in the formation of the 2-carboxy-6-hydroxyoctahydroindole (Choi) moiety found on all aeruginosin tetrapeptides, based on gene knock-out experiments. It is encoded by the aerE gene of the aerABCDEF Aeruginosin biosynthesis gene cluster in Microcystis aeruginosa. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold.


Pssm-ID: 380441 [Multi-domain]  Cd Length: 100  Bit Score: 38.78  E-value: 3.52e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1420787656  31 AAPHLHPWGTLEYAAHGVLHMDVDG-SRFMSPPHYAVWVPPQVEHSFYSHQPVNyrAVCLDPK 92
Cdd:cd20307    37 VELHQHPESQIGMVLSGELEMNVGGvKKVMEPLQDVYVAPPNVPHGAVNPSSEE--AVGLDIK 97
PRK10371 PRK10371
transcriptional regulator MelR;
219-262 4.77e-04

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 40.96  E-value: 4.77e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1420787656 219 ESTRSVQEIAFDLGYSSGSAFIAMFARQAGCTPEQYRRSHLEGR 262
Cdd:PRK10371  254 DTDKSILDIALTAGFRSSSRFYSTFGKYVGMSPQQYRKLSQQRR 297
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
176-256 8.20e-04

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 40.16  E-value: 8.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 176 LAHWAAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEALESTRSVQEIAFDLGYSSGSAFIAMFARQAGCTPEQYR 255
Cdd:PRK15435  102 LEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREALAKGESVTTSILNAGFPDSSSYYRKADETLGMTAKQFR 181


                  .
gi 1420787656 256 R 256
Cdd:PRK15435  182 H 182
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
180-260 8.30e-04

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 40.05  E-value: 8.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1420787656 180 AAQVHVSERTLARQFVRELGMSFGEWRQRLRYLAAIEALE-STRSVQEIAFDLGYSSGSAFIAMFARQAGCTPEQYRRSH 258
Cdd:PRK13503  194 ADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRhSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRDIRQGR 273


                  ..
gi 1420787656 259 LE 260
Cdd:PRK13503  274 DG 275
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
18-91 1.75e-03

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 37.14  E-value: 1.75e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1420787656  18 VYFRYADFNAHEYAAPHLHPWGTLEYAAHGVLHMDVDGSRFMSPPHYAVWVPPQVEHSFYSHQPVNYRAVCLDP 91
Cdd:COG1917    23 LEVVRVTFEPGARTPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLVVFS 96
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 166-207 1.94e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 35.21  E-value: 1.94e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1420787656 166 LQADPGNNQPLAHWAAQVHVSERTLARQFVRELGMSFGEWRQ 207
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 215-256 7.41e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 33.67  E-value: 7.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1420787656 215 IEALESTR-SVQEIAFDLGYSSgSAFIAMFARQAGCTPEQYRR 256
Cdd:pfam00165   1 LRENLSTNlTIADIADELGFSR-SYFSRLFKKYTGVTPSQYRH 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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