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Conserved domains on  [gi|1431944527|gb|RCL34130|]
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hypothetical protein DBX02_00010 [Verrucomicrobia bacterium]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 69-221 1.75e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.36  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  69 ESLEKIISAEDlviDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKL 148
Cdd:COG2956   131 EVLERLLKLGP---ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ 207

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1431944527 149 NkdiPESTSVLvkYKILICALKQGNPDQAKSILDQFDFLDDHPLFYYGNAAMHFQNDEVNEANSWLIAASKIY 221
Cdd:COG2956   208 D---PDYLPAL--PRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 69-221 1.75e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.36  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  69 ESLEKIISAEDlviDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKL 148
Cdd:COG2956   131 EVLERLLKLGP---ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ 207

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1431944527 149 NkdiPESTSVLvkYKILICALKQGNPDQAKSILDQFDFLDDHPLFYYGNAAMHFQNDEVNEANSWLIAASKIY 221
Cdd:COG2956   208 D---PDYLPAL--PRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 48-220 5.07e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.00  E-value: 5.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  48 KNQLIVLLRDAAKLVNGvRVQESLEKIISAEDLVIDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYE 127
Cdd:TIGR02917 327 NSHQARRLLASIQLRLG-RVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGI 405

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527 128 MYFVKKQYKEAETSFKSFLKLNKDIPESTSVLVkykilICALKQGNPDQAKSILDQFDF-LDDHPLFYYGNAAMHFQNDE 206
Cdd:TIGR02917 406 SKLSQGDPSEAIADLETAAQLDPELGRADLLLI-----LSYLRSGQFDKALAAAKKLEKkQPDNASLHNLLGAIYLGKGD 480

                         170
                  ....*....|....
gi 1431944527 207 VNEANSWLIAASKI 220
Cdd:TIGR02917 481 LAKAREAFEKALSI 494
TPR_1 pfam00515
Tetratricopeptide repeat;
85-117 5.82e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 33.55  E-value: 5.82e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1431944527  85 APLLNLKGAAYTKIRDFDKAQSAFAKALKIEPK 117
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 69-221 1.75e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.36  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  69 ESLEKIISAEDlviDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKL 148
Cdd:COG2956   131 EVLERLLKLGP---ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQ 207

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1431944527 149 NkdiPESTSVLvkYKILICALKQGNPDQAKSILDQFDFLDDHPLFYYGNAAMHFQNDEVNEANSWLIAASKIY 221
Cdd:COG2956   208 D---PDYLPAL--PRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 66-222 1.62e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.66  E-value: 1.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  66 RVQESLEKIISAEDLVIDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSF 145
Cdd:COG2956    23 QPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKL 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1431944527 146 LKLNKDIPEstsvlVKYKILICALKQGNPDQAKSILDQFDFLD-DHPLFYYGNAAMHFQNDEVNEANSWLIAASKIYK 222
Cdd:COG2956   103 LELDPDDAE-----ALRLLAEIYEQEGDWEKAIEVLERLLKLGpENAHAYCELAELYLEQGDYDEAIEALEKALKLDP 175
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 85-221 2.31e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.35  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  85 APLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKLNKDIPEstsvlVKYKI 164
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPE-----ARLNL 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1431944527 165 LICALKQGNPDQAKSILDQFDFLD-DHPLFYYGNAAMHFQNDEVNEANSWLIAASKIY 221
Cdd:COG4783    79 GLALLKAGDYDEALALLEKALKLDpEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 83-191 2.35e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 51.16  E-value: 2.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  83 DYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKLNKDIPESTSVLVky 162
Cdd:COG4235    15 NDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLG-- 92

                          90       100
                  ....*....|....*....|....*....
gi 1431944527 163 kilICALKQGNPDQAKSILDQfdFLDDHP 191
Cdd:COG4235    93 ---LAAFQQGDYAEAIAAWQK--LLALLP 116
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 43-192 2.46e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 51.88  E-value: 2.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  43 LNDNQKNQLIVLLRDAAKLVNGVRVQESLEKIISAEDLVIDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTS 122
Cdd:COG5010    12 LYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELY 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527 123 FNLYEMYFVKKQYKEAETSFKSFLKLNKDIPEstsvlVKYKILICALKQGNPDQAKSILDQfdFLDDHPL 192
Cdd:COG5010    92 YNLALLYSRSGDKDEAKEYYEKALALSPDNPN-----AYSNLAALLLSLGQDDEAKAALQR--ALGTSPL 154
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
83-217 5.00e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.32  E-value: 5.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  83 DYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKLNkdiPESTSVLvkY 162
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELD---PDDAEAL--N 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1431944527 163 KILICALKQGNPDQAKSILDQ-FDFLDDHPLFYYGNAAMHFQNDEVNEANSWLIAA 217
Cdd:COG0457    81 NLGLALQALGRYEEALEDYDKaLELDPDDAEALYNLGLALLELGRYDEAIEAYERA 136
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
66-199 5.87e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.93  E-value: 5.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  66 RVQESLEKIISAEDLVIDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSF 145
Cdd:COG0457    57 RYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERA 136

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1431944527 146 LKLNKDIPESTsvlvkYKILICALKQGNPDQAKSILDQFDFLDDHPLFYYGNAA 199
Cdd:COG0457   137 LELDPDDADAL-----YNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGE 185
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 94-199 6.95e-08

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 49.60  E-value: 6.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  94 AYTKIRDFDKAQSAFAKALKIEPKGVMTS---FNLYEMYFVKKQYKEAETSFKSFLKLNKDIPESTSVLvkYKILICALK 170
Cdd:COG1729     2 ALLKAGDYDEAIAAFKAFLKRYPNSPLAPdalYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDAL--LKLGLSYLE 79

                          90       100
                  ....*....|....*....|....*....
gi 1431944527 171 QGNPDQAKSILDQfdFLDDHPLFYYGNAA 199
Cdd:COG1729    80 LGDYDKARATLEE--LIKKYPDSEAAKEA 106
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
83-203 1.13e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 51.07  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  83 DYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKLNKDIPESTSVlvky 162
Cdd:COG4785   105 DLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALW---- 180

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1431944527 163 kiLICALKQGNPDQAKSILDQFDFLDDHPLFYYGNAAMHFQ 203
Cdd:COG4785   181 --LYLAERKLDPEKALALLLEDWATAYLLQGDTEEARELFK 219
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 66-235 1.31e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  66 RVQESLEKIISAEDlviDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSF 145
Cdd:COG2956    94 RAEELLEKLLELDP---DDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKA 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527 146 LKLNKDIPESTSVLVKYkilicALKQGNPDQAKSILDQFDFLDDHPLFYYGN-AAMHFQNDEVNEANSWLIAASKIYKPA 224
Cdd:COG2956   171 LKLDPDCARALLLLAEL-----YLEQGDYEEAIAALERALEQDPDYLPALPRlAELYEKLGDPEEALELLRKALELDPSD 245

                         170
                  ....*....|.
gi 1431944527 225 VNDLYKDSLIE 235
Cdd:COG2956   246 DLLLALADLLE 256
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 77-220 2.78e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 50.76  E-value: 2.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  77 AEDLVIDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKLNkdiPEST 156
Cdd:COG3914    70 AAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALN---PDFA 146

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1431944527 157 SVLVKYkiLICALKQGNPDQAKSILDQ-FDFLDDHPLFYYGNAAMHFQNDEVNEANSWLIAASKI 220
Cdd:COG3914   147 EAYLNL--GEALRRLGRLEEAIAALRRaLELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL 209
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
94-183 4.47e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.70  E-value: 4.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  94 AYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAEtSFKSFLKLNKDIPEstsvlVKYKILICALKQGN 173
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAE-----ALLNLAELLLELGD 74

                          90
                  ....*....|
gi 1431944527 174 PDQAKSILDQ 183
Cdd:COG3063    75 YDEALAYLER 84
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 46-204 9.85e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.22  E-value: 9.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  46 NQKNQLIVLLRDAAKLVNGVRVQESLEKIISAEDLVIDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNL 125
Cdd:COG3914    73 ALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNL 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527 126 YEMYFVKKQYKEAETSFKSFLKLNKDIPEStsvlvkYKILICALK-QGNPDQAKSILDQFDFLDDHPLFYYGNAAMHFQN 204
Cdd:COG3914   153 GEALRRLGRLEEAIAALRRALELDPDNAEA------LNNLGNALQdLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQ 226
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
83-151 3.53e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 44.39  E-value: 3.53e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1431944527  83 DYAPLLNLKGAAYTKIRDFDKAQsAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKLNKD 151
Cdd:COG3063    24 DNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 66-205 3.64e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 47.30  E-value: 3.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  66 RVQESLEKIISAEDLVIDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSF 145
Cdd:COG3914   127 RLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRA 206

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527 146 LKLNKDIPEstsvlVKYKILICALKQGNPDQAKSILDQFDFLDDHPlFYYGNAAMHFQND 205
Cdd:COG3914   207 LELDPDNAD-----AHSNLLFALRQACDWEVYDRFEELLAALARGP-SELSPFALLYLPD 260
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 66-149 4.50e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.00  E-value: 4.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  66 RVQESLEKIISAEDLVIDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSF 145
Cdd:COG4235    32 RYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKL 111


                  ....
gi 1431944527 146 LKLN 149
Cdd:COG4235   112 LALL 115
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 48-220 5.07e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.00  E-value: 5.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  48 KNQLIVLLRDAAKLVNGvRVQESLEKIISAEDLVIDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYE 127
Cdd:TIGR02917 327 NSHQARRLLASIQLRLG-RVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGI 405

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527 128 MYFVKKQYKEAETSFKSFLKLNKDIPESTSVLVkykilICALKQGNPDQAKSILDQFDF-LDDHPLFYYGNAAMHFQNDE 206
Cdd:TIGR02917 406 SKLSQGDPSEAIADLETAAQLDPELGRADLLLI-----LSYLRSGQFDKALAAAKKLEKkQPDNASLHNLLGAIYLGKGD 480

                         170
                  ....*....|....
gi 1431944527 207 VNEANSWLIAASKI 220
Cdd:TIGR02917 481 LAKAREAFEKALSI 494
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 83-183 5.36e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.00  E-value: 5.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  83 DYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKLNkdiPESTSVLVKY 162
Cdd:TIGR02917 463 DNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTID---PKNLRAILAL 539

                          90       100
                  ....*....|....*....|.
gi 1431944527 163 KILicALKQGNPDQAKSILDQ 183
Cdd:TIGR02917 540 AGL--YLRTGNEEEAVAWLEK 558
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 68-183 7.96e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.41  E-value: 7.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  68 QESLEKIISAEDlviDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLK 147
Cdd:COG4783    24 EALLEKALELDP---DNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALK 100

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1431944527 148 LNKDIPEstsvlVKYKILICALKQGNPDQAKSILDQ 183
Cdd:COG4783   101 LDPEHPE-----AYLRLARAYRALGRPDEAIAALEK 131
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 83-236 1.47e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.84  E-value: 1.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  83 DYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKlnKDIPESTSVLVKY 162
Cdd:TIGR02917 123 GAAELLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLT--ADPGNVDALLLKG 200

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1431944527 163 KILicaLKQGNPDQAKSILDQFDFLD-DHPLFYYGNAAMHFQNDEVNEANSWLIAASKIYKPAVNDLYKDSLIEV 236
Cdd:TIGR02917 201 DLL---LSLGNIELALAAYRKAIALRpNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDF 272
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 70-226 2.07e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.07  E-value: 2.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527  70 SLEKIISAEDLVIDYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKLN 149
Cdd:TIGR02917 586 ALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELK 665

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1431944527 150 KDIPESTSVLVKYkilicALKQGNPDQAKSILDQFDflddhplfyygnaAMHFQNDEVNEANSWLIAASKIYKPAVN 226
Cdd:TIGR02917 666 PDNTEAQIGLAQL-----LLAAKRTESAKKIAKSLQ-------------KQHPKAALGFELEGDLYLRQKDYPAAIQ 724
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 83-151 5.11e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.02  E-value: 5.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1431944527  83 DYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKLNKD 151
Cdd:COG4783    70 DEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
83-149 1.35e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 38.74  E-value: 1.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1431944527  83 DYAPLLNLKGAAYTKIRDFDKAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKLN 149
Cdd:COG4785    71 DLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELD 137
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 103-210 3.30e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.52  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1431944527 103 KAQSAFAKALKIEPKGVMTSFNLYEMYFVKKQYKEAETSFKSFLKLNkdiPESTSVLVKYkiLICALKQGNPDQAKSILD 182
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLD---PDNADALLDL--AEALLAAGDTEEAEELLE 75

                          90       100
                  ....*....|....*....|....*....
gi 1431944527 183 QFDFLD-DHPLFYYGNAAMHFQNDEVNEA 210
Cdd:COG4235    76 RALALDpDNPEALYLLGLAAFQQGDYAEA 104
TPR_1 pfam00515
Tetratricopeptide repeat;
85-117 5.82e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 33.55  E-value: 5.82e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1431944527  85 APLLNLKGAAYTKIRDFDKAQSAFAKALKIEPK 117
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 85-117 9.63e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 32.88  E-value: 9.63e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1431944527  85 APLLNLKGAAYTKIRDFDKAQSAFAKALKIEPK 117
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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