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Conserved domains on  [gi|1433559207|gb|RCW40164|]
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iron complex transport system permease protein [Halopolyspora algeriensis]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 60-360 1.20e-79

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 246.14  E-value: 1.20e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  60 IGAKLIPPAEVWTALWHPDTANG--IVIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAVVLA 137
Cdd:COG0609     4 LGAVPISLSDVLRALLGPDGDPTadLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 138 VFTLGITTMLGFIWFSFGGALLAALAVFAVGSIGrGGATPVALALAGAAISALLQAVTSALVLL-DRQSLDTYRFWKVGS 216
Cdd:COG0609    84 IVLGGGLSALGLPLAAFLGALLAALLVYLLARRG-GGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLMGS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 217 IAVTDTALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVP 296
Cdd:COG0609   163 LAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVP 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1433559207 297 HVARFLAGADHRWLLPFSALMGSCLVLLADIVGRIVARPSEIQVGVMLAMVGAPFFIALVRRRK 360
Cdd:COG0609   243 HIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 60-360 1.20e-79

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 246.14  E-value: 1.20e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  60 IGAKLIPPAEVWTALWHPDTANG--IVIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAVVLA 137
Cdd:COG0609     4 LGAVPISLSDVLRALLGPDGDPTadLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 138 VFTLGITTMLGFIWFSFGGALLAALAVFAVGSIGrGGATPVALALAGAAISALLQAVTSALVLL-DRQSLDTYRFWKVGS 216
Cdd:COG0609    84 IVLGGGLSALGLPLAAFLGALLAALLVYLLARRG-GGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLMGS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 217 IAVTDTALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVP 296
Cdd:COG0609   163 LAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVP 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1433559207 297 HVARFLAGADHRWLLPFSALMGSCLVLLADIVGRIVARPSEIQVGVMLAMVGAPFFIALVRRRK 360
Cdd:COG0609   243 HIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 60-358 1.43e-63

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 205.07  E-value: 1.43e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  60 IGAKLIPPAEVWTALWHPDT-ANGIVIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAVVLAV 138
Cdd:pfam01032  12 IGAVKISPSDVFSALLGGDDsLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 139 FTLGITTMLGFIWFSFGGALLAALAVFAVgSIGRGGATPVALALAGAAISALLQAVTSALVLL-DRQSLDTYRFWKVGSI 217
Cdd:pfam01032  92 LLGGSLSLFALPLAAFIGALLAALLVYFL-SRGRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEALQSILFWLMGSL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 218 AVTDTALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVPH 297
Cdd:pfam01032 171 SGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLIVPH 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1433559207 298 VARFLAGADHRWLLPFSALMGSCLVLLADIVGRIVARPSEIQVGVMLAMVGAPFFIALVRR 358
Cdd:pfam01032 251 IARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
60-360 8.59e-60

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 196.08  E-value: 8.59e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  60 IGAKLIPPAEVWTALWHPD-TANGIVIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAVVLAV 138
Cdd:PRK10441   30 IGAKSLPASVVLEALSGTCqSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 139 FTLGITTMLGFIWFSFGGALLAALAVFAVGSIGRGGATPVALALAGAAISALLQAVTSALVLLDRQSLDTYRFWKVGSIA 218
Cdd:PRK10441  110 ALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYDQLRFWQAGSLD 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 219 VTDTALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVPHV 298
Cdd:PRK10441  190 IRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHM 269

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1433559207 299 ARFLAGADHRWLLPFSALMGSCLVLLADIVGRIVArPSEIQVGVMLAMVGAPFFIALVRRRK 360
Cdd:PRK10441  270 ARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRRKT 330
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 114-356 1.59e-41

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 146.16  E-value: 1.59e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 114 TRNPIAAPSILGITQGAGLAVVLAVFTLGITTMLGFIWFSFGGALLAALAVFAVGSigRGGATPVALALAGAAISALLQA 193
Cdd:cd06550    22 TRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLAS--RGGLSPSKLILIGIVLSAFFSA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 194 VTSALVLLDRQSLDTYRFWKVGSIAVTDTALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAA 273
Cdd:cd06550   100 GVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDLAKSLGINVNLLRLLLLLL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 274 IAVLVGSAVAMCGPIGFVGLIVPHVARFLAGADHRWLLPFSALMGSCLVLLADIVGRIVArPSEIQVGVMLAMVGAPFFI 353
Cdd:cd06550   180 VALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL-PSELPVGPVTALLGAPYFL 258


                  ...
gi 1433559207 354 ALV 356
Cdd:cd06550   259 YLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 60-360 1.20e-79

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 246.14  E-value: 1.20e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  60 IGAKLIPPAEVWTALWHPDTANG--IVIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAVVLA 137
Cdd:COG0609     4 LGAVPISLSDVLRALLGPDGDPTadLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 138 VFTLGITTMLGFIWFSFGGALLAALAVFAVGSIGrGGATPVALALAGAAISALLQAVTSALVLL-DRQSLDTYRFWKVGS 216
Cdd:COG0609    84 IVLGGGLSALGLPLAAFLGALLAALLVYLLARRG-GGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLMGS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 217 IAVTDTALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVP 296
Cdd:COG0609   163 LAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVP 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1433559207 297 HVARFLAGADHRWLLPFSALMGSCLVLLADIVGRIVARPSEIQVGVMLAMVGAPFFIALVRRRK 360
Cdd:COG0609   243 HIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 60-358 1.43e-63

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 205.07  E-value: 1.43e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  60 IGAKLIPPAEVWTALWHPDT-ANGIVIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAVVLAV 138
Cdd:pfam01032  12 IGAVKISPSDVFSALLGGDDsLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 139 FTLGITTMLGFIWFSFGGALLAALAVFAVgSIGRGGATPVALALAGAAISALLQAVTSALVLL-DRQSLDTYRFWKVGSI 217
Cdd:pfam01032  92 LLGGSLSLFALPLAAFIGALLAALLVYFL-SRGRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEALQSILFWLMGSL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 218 AVTDTALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVPH 297
Cdd:pfam01032 171 SGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLIVPH 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1433559207 298 VARFLAGADHRWLLPFSALMGSCLVLLADIVGRIVARPSEIQVGVMLAMVGAPFFIALVRR 358
Cdd:pfam01032 251 IARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
60-360 8.59e-60

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 196.08  E-value: 8.59e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  60 IGAKLIPPAEVWTALWHPD-TANGIVIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAVVLAV 138
Cdd:PRK10441   30 IGAKSLPASVVLEALSGTCqSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 139 FTLGITTMLGFIWFSFGGALLAALAVFAVGSIGRGGATPVALALAGAAISALLQAVTSALVLLDRQSLDTYRFWKVGSIA 218
Cdd:PRK10441  110 ALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYDQLRFWQAGSLD 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 219 VTDTALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVPHV 298
Cdd:PRK10441  190 IRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHM 269

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1433559207 299 ARFLAGADHRWLLPFSALMGSCLVLLADIVGRIVArPSEIQVGVMLAMVGAPFFIALVRRRK 360
Cdd:PRK10441  270 ARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRRKT 330
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
65-359 2.63e-45

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 157.93  E-value: 2.63e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  65 IPPAEVWTALW--HPDTANGIVIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAVVLA-VFTL 141
Cdd:PRK11228   25 ISAADALNALLpgHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTsALSP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 142 GITTMLGFIWFSFGGALLAALAVFAVGSIGRGGATPVALALAGAAISALLQAVTSALVLLDRQSLDTYRFWKVGSIAVTD 221
Cdd:PRK11228  105 TPFAGYSLAFIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHAYGIFYWLAGGVSHAR 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 222 TALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVPHVARF 301
Cdd:PRK11228  185 WQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARF 264

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1433559207 302 LAGADHRWLLPFSALMGSCLVLLADIVGRIVARPSEIQVGVMLAMVGAPFFIALVRRR 359
Cdd:PRK11228  265 WIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARRR 322
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
65-360 4.99e-44

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 161.16  E-value: 4.99e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  65 IPPAEVWTALWHPDTAN--GIVIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAVVLAVFTLG 142
Cdd:PRK10577   36 LPLSQWLQALWGPDADDleQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLATLFAP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 143 ITTMLGFIWFSFGGALLAALAVFAVGsiGRGGATPVALALAGAAISALLQAVTSALVLLDRQSLDTYRFWKVGSIAVTDT 222
Cdd:PRK10577  116 ALLALASQLAAFAGGLLAAALVFALA--GGKRLSPLRLVLAGMVVSLYLGALTTLLLLFNEQYLQGLFLWGAGSLAQNDW 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 223 ALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVPHVARFL 302
Cdd:PRK10577  194 SGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFIGLAAPNLARLL 273

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 303 AGADHRWLLPFSALMGSCLVLLADIVGRIVARPS--EIQVGVMLAMVGAPFFIALVRRRK 360
Cdd:PRK10577  274 GARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGgeLLPTGAVTALIGAPLLLWLLPRLR 333
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
71-360 1.44e-43

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 153.28  E-value: 1.44e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  71 WTAL---WHPDTANGIVIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAvvlAVFTLGITTML 147
Cdd:PRK09777   30 WRALltdWQAGDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLA---SVGALLLFPSL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 148 GFIWFSFGGALLAALAVFAVGSIGrGGATPVALALAGAAISALLQAVTSALVLLDRQSLDTYRFWKVGSIAVTDTALIWQ 227
Cdd:PRK09777  107 PVMWLPLLAFIGGMAGLILLKMLA-GTHQPMKLALTGVALSALWASLTDYLMLSRPQDINNALLWLTGSLWGRDWSFVKV 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 228 VLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVPHVARFLAGADH 307
Cdd:PRK09777  186 ALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMRSLVGGRH 265

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1433559207 308 RWLLPFSALMGSCLVLLADIVGRIVARPSEIQVGVMLAMVGAPFFIALVRRRK 360
Cdd:PRK09777  266 RRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVRMR 318
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 114-356 1.59e-41

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 146.16  E-value: 1.59e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 114 TRNPIAAPSILGITQGAGLAVVLAVFTLGITTMLGFIWFSFGGALLAALAVFAVGSigRGGATPVALALAGAAISALLQA 193
Cdd:cd06550    22 TRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLAS--RGGLSPSKLILIGIVLSAFFSA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 194 VTSALVLLDRQSLDTYRFWKVGSIAVTDTALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAA 273
Cdd:cd06550   100 GVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDLAKSLGINVNLLRLLLLLL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 274 IAVLVGSAVAMCGPIGFVGLIVPHVARFLAGADHRWLLPFSALMGSCLVLLADIVGRIVArPSEIQVGVMLAMVGAPFFI 353
Cdd:cd06550   180 VALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL-PSELPVGPVTALLGAPYFL 258


                  ...
gi 1433559207 354 ALV 356
Cdd:cd06550   259 YLL 261
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 69-362 1.11e-40

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 145.77  E-value: 1.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  69 EVWTALWHPDTANGI-VIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAVVLAVFTLGIttML 147
Cdd:COG4139    34 EVWIPPTQWLSEAWQlFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGG--LL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 148 GFIWFSFGGALLAALAVFAVGSIGRGGATPVALALAGAAISALLQAVTSALVLL-DRQSLDTYRFWKVGSIAVTDTALIW 226
Cdd:COG4139   112 PPWLLSLAAIAGALLVTLLLLAFARRRLSNARLLLIGVALGIICSAIMTWAVYFsSSLDLRQLMYWMMGSFGGVDWRQLW 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 227 QVLPFLLFGLVLGLAnAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVPHVARFLAGAD 306
Cdd:COG4139   192 LLLALLPVLLWLCLQ-GKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTD 270

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1433559207 307 HRWLLPFSALMGSCLVLLADIVGRIVARPSEIQVGVMLAMVGAPFFI-ALVRRRKLV 362
Cdd:COG4139   271 HRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTATLGAPVFIwLLLRRRKIR 327
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
114-359 1.76e-40

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 151.14  E-value: 1.76e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 114 TRNPIAAPSILGITQGAGLAVVLAVFTLGITTMLGFIWFSFGGALLAALAVFAVGsiGRGGATPVALALAGAAISALLQA 193
Cdd:PRK10577  422 TRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLA--RRGGFAPERLLLTGIALSALFTA 499

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 194 VTSalVLLDRQSLDTYRF--WKVGSIAVTDTALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGI 271
Cdd:PRK10577  500 LIQ--LLLASGDPRAAQLltWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALL 577

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 272 AAIAVLVGSAVAMCGPIGFVGLIVPHVARFLAGADHRWLLPFSALMGSCLVLLADIVGRIVARPSEIQVGVMLAMVGAPF 351
Cdd:PRK10577  578 LLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPY 657


                  ....*...
gi 1433559207 352 FIALVRRR 359
Cdd:PRK10577  658 FLWLLRRS 665
btuC PRK09535
cobalamin ABC transporter permease BtuC;
77-359 3.30e-36

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 134.88  E-value: 3.30e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  77 PDTANGIVIhDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGL-AVVLAVFTLGITTMLGFIWFSFG 155
Cdd:PRK09535   84 PETAQTIVL-QIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVgAVAAIVLPLAVPFGLQAAAFAGA 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 156 GALLAALAVFAVgsigRGGATPVA-LALAGAAISALLQAVTSALVLLDRQSLDTYRFWKVGSIAVTDTALIWQVLPFLLF 234
Cdd:PRK09535  163 LVAAFGVYAIAT----ENGRTPVAtLLLAGVAVQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVV 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 235 GLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVPHVARFLAGADHRWLLPFS 314
Cdd:PRK09535  239 GFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTS 318

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1433559207 315 ALMGSCLVLLADIVGRivARPSEIQVGVMLAMVGAPFFIALVRRR 359
Cdd:PRK09535  319 ALAGASFLVATDTVAR--SGPAEVPVGIVTAALGAPFFLYLLRTR 361
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 69-363 9.38e-36

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 132.77  E-value: 9.38e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  69 EVWTALWHPDTANG-IVIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAVVLAVFtLGITTML 147
Cdd:PRK03784   37 EQWISPGDWLSPRGeLFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVL-LGQGLLP 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 148 GFIWFSFGGALLAALAVFAVGSIGRGGATPVALALAGAAISALLQA-VTSALVLLDRQSLDTYRFWKVGSIAVTDTALIW 226
Cdd:PRK03784  116 PWALSLCAIAGALLITLILLRFARRHRLSTSRLLLAGVALGIICSAlMTWAVYFSTSLDLRQLMYWMMGGFGGVDWRQSW 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 227 QVLPFLLFGLVLGLANAAgLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVPHVARFLAGAD 306
Cdd:PRK03784  196 LMLALLPVLIWLCCQGRP-LNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTD 274

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1433559207 307 HRWLLPFSALMGSCLVLLADIVGRIVARPSEIQVGVMLAMVGAPFFIALVRRRKLVR 363
Cdd:PRK03784  275 HRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLRSHRAR 331
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 65-359 2.39e-35

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 131.78  E-value: 2.39e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  65 IPPAEVWTALW-HPDTANGIVIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAVVLAVFTLGI 143
Cdd:COG4779    48 LSPGDVLRALLgEGDPGASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPDIIGITAGASAGAVAAIVVLGG 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 144 TTMLgfIWFSFGGALLAALAVFAVGSiGRGGATPVALALAGAAISALLQAVTSALVL-LDRQSLDTYRFWKVGSIAVTDT 222
Cdd:COG4779   128 SGLA--VALGALAGGLATALLVYLLA-WRGGVSGYRLILVGIGVSAMLTAVNSYLLTrADLEDAQSAAVWLTGSLNGRTW 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 223 ALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIGFVGLIVPHVARFL 302
Cdd:COG4779   205 EDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVALAAVATAAAGPIAFVALAAPQIARRL 284

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1433559207 303 AGADHRWLLPfSALMGSCLVLLADIVGRIVARPSEIQVGVMLAMVGAPFFIALVRRR 359
Cdd:COG4779   285 TRSPGPPLLP-SALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLWLLIRE 340
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
61-358 1.11e-15

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 77.06  E-value: 1.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207  61 GAKLIPPAEVWTALW-HPDTANGIVIHDLRLPRTWAGVLAGAALGLAGALLQGHTRNPIAAPSILGITQGAGLAVVLAVF 139
Cdd:PRK10440   30 GAVTLETSQVFAALMgDAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMV 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 140 TLG-------ITTMLGFIWFSFGGALLAAlavfavgsigRGGATPVALALAGAAISALLQAVTSALVLldRQSLDTYR-- 210
Cdd:PRK10440  110 LFGqdltaiaLAAMAGGIVTSLLVWLLAW----------RNGIDTFRLIIIGIGVRAMLVAFNTWLLL--KASLETALta 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433559207 211 -FWKVGSIAVTDTALIWQVLPFLLFGLVLGLANAAGLNALSLGEDVARSLGHHVGWSRAAGIAAIAVLVGSAVAMCGPIG 289
Cdd:PRK10440  178 gLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPIS 257

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1433559207 290 FVGLIVPHVARFLAGADhRWLLPFSALMGSCLVLLADIVGRIVARPSEIQVGVMLAMVGAPFFIALVRR 358
Cdd:PRK10440  258 FIALVAPHIARRLSGTA-RWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLLIQ 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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