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Conserved domains on  [gi|1440951548|gb|RDL10501|]
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A/G-specific DNA-adenine glycosylase [Streptomyces sp. HB202]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MutY super family cl34172
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ...
 15-230 6.11e-76

Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1194:

Pssm-ID: 440807 [Multi-domain]  Cd Length: 350  Bit Score: 235.80  E-value: 6.11e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  15 AASLHTPVIGWFEQHARDLPWRRpEAGAWGVMVSEFMLQQTPVSRVLPVYEQWLARWPRPADLAAeAPGEAV-RAWGRLG 93
Cdd:COG1194     3 MASFAKRLLAWYDRHGRDLPWRQ-TRDPYRVWLSEIMLQQTQVATVIPYYERFLERFPTVEALAA-APEDEVlKLWEGLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  94 YPRRALRLHGAAQAITERHGGDVPSEHAQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFARaATGVQYPPnATTA 173
Cdd:COG1194    81 YYSRARNLHKAAQQVVEEHGGVFPDTYEELLALPGIGPYTAAAIASIAFGEPAPIVDGNVKRVLSR-LFAIEGPI-GSPA 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548 174 AERKL---ARALLPdeDERAAKWAAATMELGALVCTARNEDCDRCPIASRCAWRLAGKPA 230
Cdd:COG1194   159 AKKELwalAEELLP--PERPGDFNQALMDLGATVCTPKKPKCLLCPLQDDCAAFAEGRQE 216
 
Name Accession Description Interval E-value
MutY COG1194
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ...
 15-230 6.11e-76

Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];


Pssm-ID: 440807 [Multi-domain]  Cd Length: 350  Bit Score: 235.80  E-value: 6.11e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  15 AASLHTPVIGWFEQHARDLPWRRpEAGAWGVMVSEFMLQQTPVSRVLPVYEQWLARWPRPADLAAeAPGEAV-RAWGRLG 93
Cdd:COG1194     3 MASFAKRLLAWYDRHGRDLPWRQ-TRDPYRVWLSEIMLQQTQVATVIPYYERFLERFPTVEALAA-APEDEVlKLWEGLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  94 YPRRALRLHGAAQAITERHGGDVPSEHAQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFARaATGVQYPPnATTA 173
Cdd:COG1194    81 YYSRARNLHKAAQQVVEEHGGVFPDTYEELLALPGIGPYTAAAIASIAFGEPAPIVDGNVKRVLSR-LFAIEGPI-GSPA 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548 174 AERKL---ARALLPdeDERAAKWAAATMELGALVCTARNEDCDRCPIASRCAWRLAGKPA 230
Cdd:COG1194   159 AKKELwalAEELLP--PERPGDFNQALMDLGATVCTPKKPKCLLCPLQDDCAAFAEGRQE 216
mutY TIGR01084
A/G-specific adenine glycosylase; This equivalog model identifies mutY members of the ...
 22-244 5.34e-62

A/G-specific adenine glycosylase; This equivalog model identifies mutY members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130156  Cd Length: 275  Bit Score: 197.63  E-value: 5.34e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  22 VIGWFEQHAR-DLPWRRPEAgAWGVMVSEFMLQQTPVSRVLPVYEQWLARWPRPADLAAEAPGEAVRAWGRLGYPRRALR 100
Cdd:TIGR01084   6 LLSWYDKYGRkTLPWRQNKT-PYRVWLSEVMLQQTQVATVIPYFERFLERFPTVQALANAPQDEVLKLWEGLGYYARARN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548 101 LHGAAQAITERHGGDVPSEHAQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFARaATGVQYPPNATTAAER--KL 178
Cdd:TIGR01084  85 LHKAAQEVVEEFGGEFPQDFEDLAALPGVGRYTAGAILSFALNKPYPILDGNVKRVLSR-LFAVEGWPGKKKVENRlwTL 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1440951548 179 ARALLPDEDerAAKWAAATMELGALVCTARNEDCDRCPIASRCAWRLAGKPAhEGPPRKGQTYAGT 244
Cdd:TIGR01084 164 AESLLPKAD--PEAFNQALMDLGAMICTRKKPKCDLCPLQDFCLAYQQGTWE-EYPVKKPKAAPPE 226
PRK10880 PRK10880
adenine DNA glycosylase;
22-221 3.11e-41

adenine DNA glycosylase;


Pssm-ID: 182805 [Multi-domain]  Cd Length: 350  Bit Score: 146.01  E-value: 3.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  22 VIGWFEQHARD-LPWRRpEAGAWGVMVSEFMLQQTPVSRVLPVYEQWLARWPRPADLAAEAPGEAVRAWGRLGYPRRALR 100
Cdd:PRK10880   10 VLDWYDKYGRKtLPWQI-DKTPYKVWLSEVMLQQTQVATVIPYFERFMARFPTVTDLANAPLDEVLHLWTGLGYYARARN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548 101 LHGAAQAITERHGGDVPSEHAQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFAR--AATGVqypPNATTAAER-- 176
Cdd:PRK10880   89 LHKAAQQVATLHGGEFPETFEEVAALPGVGRSTAGAILSLSLGKHFPILDGNVKRVLARcyAVSGW---PGKKEVENRlw 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1440951548 177 KLARALLPDEDerAAKWAAATMELGALVCTARNEDCDRCPIASRC 221
Cdd:PRK10880  166 QLSEQVTPAVG--VERFNQAMMDLGAMVCTRSKPKCELCPLQNGC 208
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 43-201 5.36e-39

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 134.68  E-value: 5.36e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  43 WGVMVSEFMLQQTPVSRVLPVYEQWLARW-PRPADLAAEAPGEAVRAWGRLGYPRRALRLHGAAQAITERHGGDV---PS 118
Cdd:cd00056     1 FEVLVSEILSQQTTDKAVNKAYERLFERYgPTPEALAAADEEELRELIRSLGYRRKAKYLKELARAIVEGFGGLVlddPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548 119 EHAQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFARAatgVQYPPNATTAAERKLARALLPdeDERAAKWAAATM 198
Cdd:cd00056    81 AREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRL---GLIPKKKTPEELEELLEELLP--KPYWGEANQALM 155


                  ...
gi 1440951548 199 ELG 201
Cdd:cd00056   156 DLG 158
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 51-203 3.02e-33

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 119.29  E-value: 3.02e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548   51 MLQQTPVSRVLPVYEQWLARWPRPADLAAEAPGEAVRAW-GRLGYPRRALRLHGAAQAITERHGGDVPSEHAQLLALPGI 129
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIrGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1440951548  130 GEYTAAAVASFAYGQRHAVLDTNVRRVFARAatgvqYPPNATTAAE--RKLARALLPDEDERaaKWAAATMELGAL 203
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRL-----GLVDKKSTPEevEKLLEKLLPEEDWR--ELNLLLIDFGRT 149
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 47-159 2.82e-24

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 95.43  E-value: 2.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  47 VSEFMLQQTPVSRVLPVYEQWLARW-PRPADLAAEAPGEAVRAWGRLG-YPRRALRLHGAAQAITERHGGDVPSEHAQLL 124
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEKFfPTPEDLADADEEELRELIRGLGfYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1440951548 125 A-LPGIGEYTAAAVASFAYGQRHA--VLDTNVRRVFAR 159
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGRPDPlpVVDTHVRRVLKR 118
 
Name Accession Description Interval E-value
MutY COG1194
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ...
 15-230 6.11e-76

Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair];


Pssm-ID: 440807 [Multi-domain]  Cd Length: 350  Bit Score: 235.80  E-value: 6.11e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  15 AASLHTPVIGWFEQHARDLPWRRpEAGAWGVMVSEFMLQQTPVSRVLPVYEQWLARWPRPADLAAeAPGEAV-RAWGRLG 93
Cdd:COG1194     3 MASFAKRLLAWYDRHGRDLPWRQ-TRDPYRVWLSEIMLQQTQVATVIPYYERFLERFPTVEALAA-APEDEVlKLWEGLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  94 YPRRALRLHGAAQAITERHGGDVPSEHAQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFARaATGVQYPPnATTA 173
Cdd:COG1194    81 YYSRARNLHKAAQQVVEEHGGVFPDTYEELLALPGIGPYTAAAIASIAFGEPAPIVDGNVKRVLSR-LFAIEGPI-GSPA 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548 174 AERKL---ARALLPdeDERAAKWAAATMELGALVCTARNEDCDRCPIASRCAWRLAGKPA 230
Cdd:COG1194   159 AKKELwalAEELLP--PERPGDFNQALMDLGATVCTPKKPKCLLCPLQDDCAAFAEGRQE 216
mutY TIGR01084
A/G-specific adenine glycosylase; This equivalog model identifies mutY members of the ...
 22-244 5.34e-62

A/G-specific adenine glycosylase; This equivalog model identifies mutY members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130156  Cd Length: 275  Bit Score: 197.63  E-value: 5.34e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  22 VIGWFEQHAR-DLPWRRPEAgAWGVMVSEFMLQQTPVSRVLPVYEQWLARWPRPADLAAEAPGEAVRAWGRLGYPRRALR 100
Cdd:TIGR01084   6 LLSWYDKYGRkTLPWRQNKT-PYRVWLSEVMLQQTQVATVIPYFERFLERFPTVQALANAPQDEVLKLWEGLGYYARARN 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548 101 LHGAAQAITERHGGDVPSEHAQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFARaATGVQYPPNATTAAER--KL 178
Cdd:TIGR01084  85 LHKAAQEVVEEFGGEFPQDFEDLAALPGVGRYTAGAILSFALNKPYPILDGNVKRVLSR-LFAVEGWPGKKKVENRlwTL 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1440951548 179 ARALLPDEDerAAKWAAATMELGALVCTARNEDCDRCPIASRCAWRLAGKPAhEGPPRKGQTYAGT 244
Cdd:TIGR01084 164 AESLLPKAD--PEAFNQALMDLGAMICTRKKPKCDLCPLQDFCLAYQQGTWE-EYPVKKPKAAPPE 226
PRK10880 PRK10880
adenine DNA glycosylase;
22-221 3.11e-41

adenine DNA glycosylase;


Pssm-ID: 182805 [Multi-domain]  Cd Length: 350  Bit Score: 146.01  E-value: 3.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  22 VIGWFEQHARD-LPWRRpEAGAWGVMVSEFMLQQTPVSRVLPVYEQWLARWPRPADLAAEAPGEAVRAWGRLGYPRRALR 100
Cdd:PRK10880   10 VLDWYDKYGRKtLPWQI-DKTPYKVWLSEVMLQQTQVATVIPYFERFMARFPTVTDLANAPLDEVLHLWTGLGYYARARN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548 101 LHGAAQAITERHGGDVPSEHAQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFAR--AATGVqypPNATTAAER-- 176
Cdd:PRK10880   89 LHKAAQQVATLHGGEFPETFEEVAALPGVGRSTAGAILSLSLGKHFPILDGNVKRVLARcyAVSGW---PGKKEVENRlw 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1440951548 177 KLARALLPDEDerAAKWAAATMELGALVCTARNEDCDRCPIASRC 221
Cdd:PRK10880  166 QLSEQVTPAVG--VERFNQAMMDLGAMVCTRSKPKCELCPLQNGC 208
ENDO3c cd00056
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 43-201 5.36e-39

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 238013 [Multi-domain]  Cd Length: 158  Bit Score: 134.68  E-value: 5.36e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  43 WGVMVSEFMLQQTPVSRVLPVYEQWLARW-PRPADLAAEAPGEAVRAWGRLGYPRRALRLHGAAQAITERHGGDV---PS 118
Cdd:cd00056     1 FEVLVSEILSQQTTDKAVNKAYERLFERYgPTPEALAAADEEELRELIRSLGYRRKAKYLKELARAIVEGFGGLVlddPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548 119 EHAQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFARAatgVQYPPNATTAAERKLARALLPdeDERAAKWAAATM 198
Cdd:cd00056    81 AREELLALPGVGRKTANVVLLFALGPDAFPVDTHVRRVLKRL---GLIPKKKTPEELEELLEELLP--KPYWGEANQALM 155


                  ...
gi 1440951548 199 ELG 201
Cdd:cd00056   156 DLG 158
ENDO3c smart00478
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ...
 51-203 3.02e-33

endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases


Pssm-ID: 214684 [Multi-domain]  Cd Length: 149  Bit Score: 119.29  E-value: 3.02e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548   51 MLQQTPVSRVLPVYEQWLARWPRPADLAAEAPGEAVRAW-GRLGYPRRALRLHGAAQAITERHGGDVPSEHAQLLALPGI 129
Cdd:smart00478   1 LSQQTTDERVNKATERLFEKFPTPEDLAAADEEELEELIrGLGFYRRKARYLIELARILVEEYGGEVPDDREELLKLPGV 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1440951548  130 GEYTAAAVASFAYGQRHAVLDTNVRRVFARAatgvqYPPNATTAAE--RKLARALLPDEDERaaKWAAATMELGAL 203
Cdd:smart00478  81 GRKTANAVLSFALGKPFIPVDTHVLRIAKRL-----GLVDKKSTPEevEKLLEKLLPEEDWR--ELNLLLIDFGRT 149
Nth COG0177
Endonuclease III [Replication, recombination and repair];
53-224 2.03e-29

Endonuclease III [Replication, recombination and repair];


Pssm-ID: 439947 [Multi-domain]  Cd Length: 198  Bit Score: 110.96  E-value: 2.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  53 QQTPVSRVLPVYEQWLARWPRPADLAAEAPGEAVRAWGRLGYPR-RALRLHGAAQAITERHGGDVPSEHAQLLALPGIGE 131
Cdd:COG0177    31 AQTTDERVNKATPRLFARYPTPEALAAADLEELEELIRPIGLYRnKAKNIIALARILVEKYGGEVPETREELESLPGVGR 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548 132 YTAAAVASFAYGQRHAVLDTNVRRVFARaaTGVQyPPNATTAAERKLaRALLPDEDeraakWAAATM---ELGALVCTAR 208
Cdd:COG0177   111 KTANVVLNFAFGKPAIAVDTHVHRVSNR--LGLV-PGKDPEEVEKDL-MKLIPKEY-----WGDLHHlliLHGRYICKAR 181

                         170
                  ....*....|....*.
gi 1440951548 209 NEDCDRCPIASRCAWR 224
Cdd:COG0177   182 KPKCEECPLADLCPYY 197
HhH-GPD pfam00730
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ...
 47-159 2.82e-24

HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.


Pssm-ID: 425841 [Multi-domain]  Cd Length: 141  Bit Score: 95.43  E-value: 2.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  47 VSEFMLQQTPVSRVLPVYEQWLARW-PRPADLAAEAPGEAVRAWGRLG-YPRRALRLHGAAQAITERHGGDVPSEHAQLL 124
Cdd:pfam00730   1 VSAILSQQTSDKAVNKITERLFEKFfPTPEDLADADEEELRELIRGLGfYRRKAKYLKELARILVEGYGGEVPLDEEELE 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1440951548 125 A-LPGIGEYTAAAVASFAYGQRHA--VLDTNVRRVFAR 159
Cdd:pfam00730  81 AlLKGVGRWTAEAVLIFALGRPDPlpVVDTHVRRVLKR 118
PRK13910 PRK13910
DNA glycosylase MutY; Provisional
 51-221 1.65e-18

DNA glycosylase MutY; Provisional


Pssm-ID: 172427 [Multi-domain]  Cd Length: 289  Bit Score: 83.53  E-value: 1.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  51 MLQQTPVSRVLP-VYEQWLARWPRPADLAAEAPGEAVRAWGRLGYPRRALRLHGAAQAITERHGGDVPSEHAQLLALPGI 129
Cdd:PRK13910    1 MSQQTQINTVVErFYSPFLEAFPTLKDLANAPLEEVLLLWRGLGYYSRAKNLKKSAEICVKEHHSQLPNDYQSLLKLPGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548 130 GEYTAAAVASFAYGQRHAVLDTNVRRVFARAatgVQYPPNATTAAERKLARALLpdEDERAAKWAAATMELGALVCTARN 209
Cdd:PRK13910   81 GAYTANAILCFGFREKSACVDANIKRVLLRL---FGLDPNIHAKDLQIKANDFL--NLNESFNHNQALIDLGALICSPKP 155

                         170
                  ....*....|..
gi 1440951548 210 EdCDRCPIASRC 221
Cdd:PRK13910  156 K-CAICPLNPYC 166
PRK10702 PRK10702
endonuclease III; Provisional
 110-224 1.44e-09

endonuclease III; Provisional


Pssm-ID: 182661 [Multi-domain]  Cd Length: 211  Bit Score: 56.95  E-value: 1.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548 110 ERHGGDVPSEHAQLLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFARAatgvQYPPNATT-AAERKLARALLPDEDE 188
Cdd:PRK10702   98 EQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRT----QFAPGKNVeQVEEKLLKVVPAEFKV 173

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1440951548 189 RAAKWaaaTMELGALVCTARNEDCDRCPIASRCAWR 224
Cdd:PRK10702  174 DCHHW---LILHGRYTCIARKPRCGSCIIEDLCEYK 206
HP0602 COG2231
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and ...
 94-224 4.21e-07

3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and repair];


Pssm-ID: 441832 [Multi-domain]  Cd Length: 220  Bit Score: 49.84  E-value: 4.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  94 YPRRALRLHGAAQAITERHGGDVPSEHAQ--------LLALPGIGEYTAAAVASFAYGQRHAVLDTNVRRVFARAatGVQ 165
Cdd:COG2231    83 YNQKAKRLKNLARWLVERYGGGLEKLKALpteelreeLLSLKGIGPETADSILLYAFNRPVFVVDAYTRRIFSRL--GLI 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1440951548 166 yPPNATTAAERKLARALLPDEDERAAKWAAATMELGALVCTARnEDCDRCPIASRCAWR 224
Cdd:COG2231   161 -EEDASYDELQRLFEENLPPDVALYNEFHALIVEHGKEYCKKK-PKCEECPLRDLCPYG 217
AlkA COG0122
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ...
 72-160 3.87e-05

3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair];


Pssm-ID: 439892 [Multi-domain]  Cd Length: 255  Bit Score: 44.10  E-value: 3.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1440951548  72 PRPADLAAeAPGEAVRAWGrLGyPRRALRLHGAAQAITER-------HGGDVPSEHAQLLALPGIGEYTAAAVASFAYGQ 144
Cdd:COG0122   128 PTPEALAA-ASEEELRACG-LS-RRKARYLRALARAVADGeldlealAGLDDEEAIARLTALPGIGPWTAEMVLLFALGR 204

                          90
                  ....*....|....*...
gi 1440951548 145 RHAVL--DTNVRRVFARA 160
Cdd:COG0122   205 PDAFPagDLGLRRALGRL 222
HHH pfam00633
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ...
 111-140 4.63e-05

Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.


Pssm-ID: 425789 [Multi-domain]  Cd Length: 30  Bit Score: 39.71  E-value: 4.63e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1440951548 111 RHGGDVPSEHAQLLALPGIGEYTAAAVASF 140
Cdd:pfam00633   1 SLEGLIPASVEELLALPGVGPKTAEAILSY 30
EndIII_4Fe-2S pfam10576
Iron-sulfur binding domain of endonuclease III; Escherichia coli endonuclease III (EC 4.2.99. ...
 205-221 2.04e-04

Iron-sulfur binding domain of endonuclease III; Escherichia coli endonuclease III (EC 4.2.99.18) is a DNA repair enzyme that acts both as a DNA N-glycosylase, removing oxidized pyrimidines from DNA, and as an apurinic/apyrimidinic (AP) endonuclease, introducing a single-strand nick at the site from which the damaged base was removed. Endonuclease III is an iron-sulfur protein that binds a single 4Fe-4S cluster. The 4Fe-4S cluster does not seem to be important for catalytic activity, but is probably involved in the proper positioning of the enzyme along the DNA strand. The 4Fe-4S cluster is bound by four cysteines which are all located in a 17 amino acid region at the C-terminal end of endonuclease III. A similar region is also present in the central section of mutY and in the C-terminus of ORF-10 and of the Micro-coccus UV endonuclease.


Pssm-ID: 463153 [Multi-domain]  Cd Length: 17  Bit Score: 37.75  E-value: 2.04e-04
                          10
                  ....*....|....*..
gi 1440951548 205 CTARNEDCDRCPIASRC 221
Cdd:pfam10576   1 CTARKPKCEECPLADLC 17
FES smart00525
iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); ...
 204-224 3.50e-04

iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3);


Pssm-ID: 197771 [Multi-domain]  Cd Length: 21  Bit Score: 37.14  E-value: 3.50e-04
                           10        20
                   ....*....|....*....|.
gi 1440951548  204 VCTARNEDCDRCPIASRCAWR 224
Cdd:smart00525   1 ICTARKPRCDECPLKDLCPAY 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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