NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1466297676|gb|RGG58922|]
View 

redox-regulated ATPase YchF [Ruminococcus sp. AF19-15]

Protein Classification

redox-regulated ATPase YchF( domain architecture ID 17564584)

redox-regulated ATPase YchF belongs to the Obg (GTPase) family, but actually prefers ATP, associates with ribosomes, and appears to be regulated by the redox state of the cell

CATH:  3.40.50.300|3.10.20.30|1.10.150.300
EC:  3.6.-.-
Gene Ontology:  GO:0005524|GO:0016887|GO:0046872|GO:0043022
PubMed:  16333325|11489118|21527254
SCOP:  4004039

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GTP1 COG0012
Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis] ...
 1-364 0e+00

Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 439783 [Multi-domain]  Cd Length: 362  Bit Score: 719.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   1 MKLGMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERLDKLAEMYHPVKFTPATLEFVDIAGLVKGASK 80
Cdd:COG0012     1 LKCGIVGLPNVGKSTLFNALTKAGAEAANYPFCTIEPNVGVVPVPDERLDKLAEIVKPKKIVPATIEFVDIAGLVKGASK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  81 GEGLGNKFLSNIREVDAIVHVVRCFDDPNIIHVDGSINPRRDIETIDLELIFSDVELIERKLDRTKKAMK-GDKSLASAV 159
Cdd:COG0012    81 GEGLGNQFLANIREVDAIVHVVRCFEDDNVTHVEGSVDPLRDIETINTELILADLETVEKRLERLEKKAKsGDKEAKAEL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 160 EFLEKLKEHLESGKPARSYDMTEDELEILKETPLLSLKPVIYAANLCEDDFrnnIESNEHYKEVCEIAKAEGSAVFPICA 239
Cdd:COG0012   161 ELLEKLKEHLEEGKPARSLELSEEEKKLLKELQLLTAKPVLYVANVDEDDL---AEGNPYVEKVREYAAKEGAEVVVICA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 240 QIEAEISDMDDEDKEMFLADLGLETSGLNRIIKEGYSLLGLISYLTAGEPEVRAWTIKKGTKAPQAAGKIHTDFEKGFIR 319
Cdd:COG0012   238 KIEAELAELDEEERAEFLEELGLEESGLDRLIRAGYDLLGLITFFTAGPKEVRAWTIKKGTTAPQAAGVIHTDFERGFIR 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1466297676 320 AEVVSFDDLMSCGSMTAAKEKGLVRLEGKDYVMQDGDIVLFRFNV 364
Cdd:COG0012   318 AEVISYDDLIAYGSEAAAKEAGKLRLEGKDYVVQDGDVIHFRFNV 362
 
Name Accession Description Interval E-value
GTP1 COG0012
Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis] ...
 1-364 0e+00

Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439783 [Multi-domain]  Cd Length: 362  Bit Score: 719.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   1 MKLGMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERLDKLAEMYHPVKFTPATLEFVDIAGLVKGASK 80
Cdd:COG0012     1 LKCGIVGLPNVGKSTLFNALTKAGAEAANYPFCTIEPNVGVVPVPDERLDKLAEIVKPKKIVPATIEFVDIAGLVKGASK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  81 GEGLGNKFLSNIREVDAIVHVVRCFDDPNIIHVDGSINPRRDIETIDLELIFSDVELIERKLDRTKKAMK-GDKSLASAV 159
Cdd:COG0012    81 GEGLGNQFLANIREVDAIVHVVRCFEDDNVTHVEGSVDPLRDIETINTELILADLETVEKRLERLEKKAKsGDKEAKAEL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 160 EFLEKLKEHLESGKPARSYDMTEDELEILKETPLLSLKPVIYAANLCEDDFrnnIESNEHYKEVCEIAKAEGSAVFPICA 239
Cdd:COG0012   161 ELLEKLKEHLEEGKPARSLELSEEEKKLLKELQLLTAKPVLYVANVDEDDL---AEGNPYVEKVREYAAKEGAEVVVICA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 240 QIEAEISDMDDEDKEMFLADLGLETSGLNRIIKEGYSLLGLISYLTAGEPEVRAWTIKKGTKAPQAAGKIHTDFEKGFIR 319
Cdd:COG0012   238 KIEAELAELDEEERAEFLEELGLEESGLDRLIRAGYDLLGLITFFTAGPKEVRAWTIKKGTTAPQAAGVIHTDFERGFIR 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1466297676 320 AEVVSFDDLMSCGSMTAAKEKGLVRLEGKDYVMQDGDIVLFRFNV 364
Cdd:COG0012   318 AEVISYDDLIAYGSEAAAKEAGKLRLEGKDYVVQDGDVIHFRFNV 362
PTZ00258 PTZ00258
GTP-binding protein; Provisional
 2-364 8.54e-180

GTP-binding protein; Provisional


Pssm-ID: 240334 [Multi-domain]  Cd Length: 390  Bit Score: 504.09  E-value: 8.54e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   2 KLGMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERLDKLAEMYHPVKFTPATLEFVDIAGLVKGASKG 81
Cdd:PTZ00258   23 KMGIVGLPNVGKSTTFNALCKQQVPAENFPFCTIDPNTARVNVPDERFDWLCKHFKPKSIVPAQLDITDIAGLVKGASEG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  82 EGLGNKFLSNIREVDAIVHVVRCFDDPNIIHVDGSINPRRDIETIDLELIFSDVELIERKLDRTKKAMKGDKS---LASA 158
Cdd:PTZ00258  103 EGLGNAFLSHIRAVDGIYHVVRAFEDEDITHVEGEIDPVRDLEIISSELILKDLEFVEKRLDELTKKRKKKKKkkeEKVE 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 159 VEFLEKLKEHLESGKPARSYDMTEDELEILKETPLLSLKPVIYAANLCEDDFRNniESNEHYKEVCE-IAKAEGSAVFPI 237
Cdd:PTZ00258  183 LDVLKKVLEWLEEGKPVRDGDWTDKEIEILNEYQLLTAKPMIYLVNMSEKDFIR--QKNKWLAKIKEwVGEKGGGPIIPY 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 238 CAQIEAEISDM-DDEDKEMFLADLGLETSGLNRIIKEGYSLLGLISYLTAGEPEVRAWTIKKGTKAPQAAGKIHTDFEKG 316
Cdd:PTZ00258  261 SAEFEEELAELgSEEERKEYLEEYGIKQSMLDKIIKTGYKLLNLIHFFTAGPDEVRCWTIQKGTKAPQAAGVIHSDFEKG 340

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1466297676 317 FIRAEVVSFDDLMSCGSMTAAKEKGLVRLEGKDYVMQDGDIVLFRFNV 364
Cdd:PTZ00258  341 FICAEVMKYEDFLELGSEAAVKAEGKYRQEGKDYVVQDGDIIFFKFNV 388
YchF cd01900
YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of ...
 4-278 1.79e-168

YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated with the ribosome. Several members of the family, including YchF, possess the TGS domain related to the RNA-binding proteins. Experimental data and genomic analysis suggest that YchF may be part of a nucleoprotein complex and may function as a GTP-dependent translational factor.


Pssm-ID: 206687 [Multi-domain]  Cd Length: 274  Bit Score: 470.79  E-value: 1.79e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   4 GMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERLDKLAEMYHPVKFTPATLEFVDIAGLVKGASKGEG 83
Cdd:cd01900     2 GIVGLPNVGKSTLFNALTKSNAEAANYPFCTIEPNVGIVPVPDERLDKLAEIVKPKKIVPATIEFVDIAGLVKGASKGEG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  84 LGNKFLSNIREVDAIVHVVRCFDDPNIIHVDGSINPRRDIETIDLELIFSDVELIERKLDRTKKAMK-GDKSLASAVEFL 162
Cdd:cd01900    82 LGNKFLSHIREVDAIAHVVRCFEDDDITHVEGSVDPVRDIEIINTELILADLETIEKRLERLEKKAKsGDKEAKEELELL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 163 EKLKEHLESGKPARSYDMTEDELEILKETPLLSLKPVIYAANLCEDDFRNNiesNEHYKEVCEIAKAEGSAVFPICAQIE 242
Cdd:cd01900   162 EKIKEHLEEGKPARTLELTDEEIKILKSLQLLTAKPVIYVANVSEDDLIRG---NNKVLKVREIAAKEGAEVIPISAKLE 238

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1466297676 243 AEISDMDDEDKEMFLADLGLETSGLNRIIKEGYSLL 278
Cdd:cd01900   239 AELAELDEEEAAEFLEELGLEESGLDKLIRAGYELL 274
TIGR00092 TIGR00092
GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in ...
 4-364 4.48e-138

GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in every complete bacterial genome, and is found in Eukaryotes. A more distantly related protein, separated from this model, is found in the archaea. It is known to bind GTP and double-stranded nucleic acid. It is suggested to belong to a nucleoprotein complex and act as a translation factor. [Unknown function, General]


Pssm-ID: 129200 [Multi-domain]  Cd Length: 368  Bit Score: 397.22  E-value: 4.48e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   4 GMVGLPNVGKSTLFNALTNA-GAESANYPFCTIEPNVGIVSVPDERLDKLAEMYHPVKFTPATLEFVDIAGLVKGASKGE 82
Cdd:TIGR00092   6 GIVGLPNVGKSTLFAATTNLlGNEAANPPFTTIEPNAGVVNPSDPRLDLLAIYIKPEKVPPTTTEFVDIAGLVGGASKGE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  83 GLGNKFLSNIREVDAIVHVVRCFDDPNIIHVDGSINPRRDIETIDLELIFSDVELIERKLDRTKKAMKGDKSLASAVEFL 162
Cdd:TIGR00092  86 GLGNQFLANIREVDIIQHVVRCFEDDIIHHVGNVDDPRDDFEIIDEELLKADEFLVEKRIGRSKKSAEGGKDKKEELLLL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 163 EKLKEHLESGKPARSYDMTEDELEILKETPLLSLKPVIYAANLCEDDFRNniESNEHYKEVCEIAKA--EGSAVFPICAQ 240
Cdd:TIGR00092 166 EIILPLLNGGQMARHVDLSKEELILIKSLNLLTKKPIILIANVSEDYLRN--LNNNYLLIVEWIAAYskGDPKVVFVCAL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 241 IEAEISDMDDEDKEMFLADLGLETS-GLNRIIKEGYSLLGLISYLTAGEPEVRAWTIKKGTKAPQAAGKIHTDFEKGFIR 319
Cdd:TIGR00092 244 EESELSELDDEERQEFLQKLGLTESaGLNIIIRARYKLLLLSFFFTGGKEEVRAWTRKGGWAAPQAAGIIHTDFETGFIA 323

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1466297676 320 AEVVSFDDLMSCGSMTAAKEKGLVRLEGKDYVMQDGDIVLFRFNV 364
Cdd:TIGR00092 324 AEVISWDDFIYKKSSQGAKKGGLMRLEGKYYVVDDGDVLFFAFNV 368
YchF-GTPase_C pfam06071
Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF ...
 280-361 5.42e-59

Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF GTP-binding protein and is possibly related to the ubiquitin-like and MoaD/ThiS superfamilies.


Pssm-ID: 461819 [Multi-domain]  Cd Length: 82  Bit Score: 185.25  E-value: 5.42e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 280 LISYLTAGEPEVRAWTIKKGTKAPQAAGKIHTDFEKGFIRAEVVSFDDLMSCGSMTAAKEKGLVRLEGKDYVMQDGDIVL 359
Cdd:pfam06071   1 LITFFTAGPKEVRAWTIRKGTTAPQAAGVIHTDFEKGFIRAEVISYDDLIEYGSEAAAKEAGKLRLEGKDYVVQDGDIIH 80


                  ..
gi 1466297676 360 FR 361
Cdd:pfam06071  81 FR 82
 
Name Accession Description Interval E-value
GTP1 COG0012
Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis] ...
 1-364 0e+00

Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439783 [Multi-domain]  Cd Length: 362  Bit Score: 719.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   1 MKLGMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERLDKLAEMYHPVKFTPATLEFVDIAGLVKGASK 80
Cdd:COG0012     1 LKCGIVGLPNVGKSTLFNALTKAGAEAANYPFCTIEPNVGVVPVPDERLDKLAEIVKPKKIVPATIEFVDIAGLVKGASK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  81 GEGLGNKFLSNIREVDAIVHVVRCFDDPNIIHVDGSINPRRDIETIDLELIFSDVELIERKLDRTKKAMK-GDKSLASAV 159
Cdd:COG0012    81 GEGLGNQFLANIREVDAIVHVVRCFEDDNVTHVEGSVDPLRDIETINTELILADLETVEKRLERLEKKAKsGDKEAKAEL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 160 EFLEKLKEHLESGKPARSYDMTEDELEILKETPLLSLKPVIYAANLCEDDFrnnIESNEHYKEVCEIAKAEGSAVFPICA 239
Cdd:COG0012   161 ELLEKLKEHLEEGKPARSLELSEEEKKLLKELQLLTAKPVLYVANVDEDDL---AEGNPYVEKVREYAAKEGAEVVVICA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 240 QIEAEISDMDDEDKEMFLADLGLETSGLNRIIKEGYSLLGLISYLTAGEPEVRAWTIKKGTKAPQAAGKIHTDFEKGFIR 319
Cdd:COG0012   238 KIEAELAELDEEERAEFLEELGLEESGLDRLIRAGYDLLGLITFFTAGPKEVRAWTIKKGTTAPQAAGVIHTDFERGFIR 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1466297676 320 AEVVSFDDLMSCGSMTAAKEKGLVRLEGKDYVMQDGDIVLFRFNV 364
Cdd:COG0012   318 AEVISYDDLIAYGSEAAAKEAGKLRLEGKDYVVQDGDVIHFRFNV 362
PTZ00258 PTZ00258
GTP-binding protein; Provisional
 2-364 8.54e-180

GTP-binding protein; Provisional


Pssm-ID: 240334 [Multi-domain]  Cd Length: 390  Bit Score: 504.09  E-value: 8.54e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   2 KLGMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERLDKLAEMYHPVKFTPATLEFVDIAGLVKGASKG 81
Cdd:PTZ00258   23 KMGIVGLPNVGKSTTFNALCKQQVPAENFPFCTIDPNTARVNVPDERFDWLCKHFKPKSIVPAQLDITDIAGLVKGASEG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  82 EGLGNKFLSNIREVDAIVHVVRCFDDPNIIHVDGSINPRRDIETIDLELIFSDVELIERKLDRTKKAMKGDKS---LASA 158
Cdd:PTZ00258  103 EGLGNAFLSHIRAVDGIYHVVRAFEDEDITHVEGEIDPVRDLEIISSELILKDLEFVEKRLDELTKKRKKKKKkkeEKVE 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 159 VEFLEKLKEHLESGKPARSYDMTEDELEILKETPLLSLKPVIYAANLCEDDFRNniESNEHYKEVCE-IAKAEGSAVFPI 237
Cdd:PTZ00258  183 LDVLKKVLEWLEEGKPVRDGDWTDKEIEILNEYQLLTAKPMIYLVNMSEKDFIR--QKNKWLAKIKEwVGEKGGGPIIPY 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 238 CAQIEAEISDM-DDEDKEMFLADLGLETSGLNRIIKEGYSLLGLISYLTAGEPEVRAWTIKKGTKAPQAAGKIHTDFEKG 316
Cdd:PTZ00258  261 SAEFEEELAELgSEEERKEYLEEYGIKQSMLDKIIKTGYKLLNLIHFFTAGPDEVRCWTIQKGTKAPQAAGVIHSDFEKG 340

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1466297676 317 FIRAEVVSFDDLMSCGSMTAAKEKGLVRLEGKDYVMQDGDIVLFRFNV 364
Cdd:PTZ00258  341 FICAEVMKYEDFLELGSEAAVKAEGKYRQEGKDYVVQDGDIIFFKFNV 388
YchF cd01900
YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of ...
 4-278 1.79e-168

YchF GTPase; YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated with the ribosome. Several members of the family, including YchF, possess the TGS domain related to the RNA-binding proteins. Experimental data and genomic analysis suggest that YchF may be part of a nucleoprotein complex and may function as a GTP-dependent translational factor.


Pssm-ID: 206687 [Multi-domain]  Cd Length: 274  Bit Score: 470.79  E-value: 1.79e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   4 GMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERLDKLAEMYHPVKFTPATLEFVDIAGLVKGASKGEG 83
Cdd:cd01900     2 GIVGLPNVGKSTLFNALTKSNAEAANYPFCTIEPNVGIVPVPDERLDKLAEIVKPKKIVPATIEFVDIAGLVKGASKGEG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  84 LGNKFLSNIREVDAIVHVVRCFDDPNIIHVDGSINPRRDIETIDLELIFSDVELIERKLDRTKKAMK-GDKSLASAVEFL 162
Cdd:cd01900    82 LGNKFLSHIREVDAIAHVVRCFEDDDITHVEGSVDPVRDIEIINTELILADLETIEKRLERLEKKAKsGDKEAKEELELL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 163 EKLKEHLESGKPARSYDMTEDELEILKETPLLSLKPVIYAANLCEDDFRNNiesNEHYKEVCEIAKAEGSAVFPICAQIE 242
Cdd:cd01900   162 EKIKEHLEEGKPARTLELTDEEIKILKSLQLLTAKPVIYVANVSEDDLIRG---NNKVLKVREIAAKEGAEVIPISAKLE 238

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1466297676 243 AEISDMDDEDKEMFLADLGLETSGLNRIIKEGYSLL 278
Cdd:cd01900   239 AELAELDEEEAAEFLEELGLEESGLDKLIRAGYELL 274
TIGR00092 TIGR00092
GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in ...
 4-364 4.48e-138

GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in every complete bacterial genome, and is found in Eukaryotes. A more distantly related protein, separated from this model, is found in the archaea. It is known to bind GTP and double-stranded nucleic acid. It is suggested to belong to a nucleoprotein complex and act as a translation factor. [Unknown function, General]


Pssm-ID: 129200 [Multi-domain]  Cd Length: 368  Bit Score: 397.22  E-value: 4.48e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   4 GMVGLPNVGKSTLFNALTNA-GAESANYPFCTIEPNVGIVSVPDERLDKLAEMYHPVKFTPATLEFVDIAGLVKGASKGE 82
Cdd:TIGR00092   6 GIVGLPNVGKSTLFAATTNLlGNEAANPPFTTIEPNAGVVNPSDPRLDLLAIYIKPEKVPPTTTEFVDIAGLVGGASKGE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  83 GLGNKFLSNIREVDAIVHVVRCFDDPNIIHVDGSINPRRDIETIDLELIFSDVELIERKLDRTKKAMKGDKSLASAVEFL 162
Cdd:TIGR00092  86 GLGNQFLANIREVDIIQHVVRCFEDDIIHHVGNVDDPRDDFEIIDEELLKADEFLVEKRIGRSKKSAEGGKDKKEELLLL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 163 EKLKEHLESGKPARSYDMTEDELEILKETPLLSLKPVIYAANLCEDDFRNniESNEHYKEVCEIAKA--EGSAVFPICAQ 240
Cdd:TIGR00092 166 EIILPLLNGGQMARHVDLSKEELILIKSLNLLTKKPIILIANVSEDYLRN--LNNNYLLIVEWIAAYskGDPKVVFVCAL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 241 IEAEISDMDDEDKEMFLADLGLETS-GLNRIIKEGYSLLGLISYLTAGEPEVRAWTIKKGTKAPQAAGKIHTDFEKGFIR 319
Cdd:TIGR00092 244 EESELSELDDEERQEFLQKLGLTESaGLNIIIRARYKLLLLSFFFTGGKEEVRAWTRKGGWAAPQAAGIIHTDFETGFIA 323

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1466297676 320 AEVVSFDDLMSCGSMTAAKEKGLVRLEGKDYVMQDGDIVLFRFNV 364
Cdd:TIGR00092 324 AEVISWDDFIYKKSSQGAKKGGLMRLEGKYYVVDDGDVLFFAFNV 368
YchF-GTPase_C pfam06071
Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF ...
 280-361 5.42e-59

Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF GTP-binding protein and is possibly related to the ubiquitin-like and MoaD/ThiS superfamilies.


Pssm-ID: 461819 [Multi-domain]  Cd Length: 82  Bit Score: 185.25  E-value: 5.42e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 280 LISYLTAGEPEVRAWTIKKGTKAPQAAGKIHTDFEKGFIRAEVVSFDDLMSCGSMTAAKEKGLVRLEGKDYVMQDGDIVL 359
Cdd:pfam06071   1 LITFFTAGPKEVRAWTIRKGTTAPQAAGVIHTDFEKGFIRAEVISYDDLIEYGSEAAAKEAGKLRLEGKDYVVQDGDIIH 80


                  ..
gi 1466297676 360 FR 361
Cdd:pfam06071  81 FR 82
TGS_YchF_OLA1 cd04867
TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 ...
 278-362 1.39e-56

TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 family includes bacterial ribosome-binding ATPase YchF as well as its human homolog Obg-like ATPase 1 (OLA1), both of which belong to the Obg family of GTPases, and are novel ATPases that bind and hydrolyze ATP more efficiently than GTP. They have been associated with various cellular processes and pathologies, including DNA repair, tumorigenesis, and apoptosis, in addition to the regulation of the oxidative stress response. OLA1 is also termed DNA damage-regulated overexpressed in cancer 45 (DOC45), or GTP-binding protein 9 (GTPBP9). It is over-expressed in several human malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus. It is linked to the cellular stress response and tumorigenesis, and may also serve as a valuable tumor marker. Members in this family contain a central Obg-type G (guanine nucleotide-binding) domain, flanked by a coiled-coil domain and this TGS (ThrRS, GTPase, SpoT) domain of unknown function.


Pssm-ID: 340516 [Multi-domain]  Cd Length: 85  Bit Score: 179.26  E-value: 1.39e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 278 LGLISYLTAGEPEVRAWTIKKGTKAPQAAGKIHTDFEKGFIRAEVVSFDDLMSCGSMTAAKEKGLVRLEGKDYVMQDGDI 357
Cdd:cd04867     1 LNLITFFTAGPDEVRAWTIRKGTKAPQAAGVIHTDFEKGFIRAEVIKYDDLKELGSEAAAKEAGKYRQEGKDYVVQDGDI 80


                  ....*
gi 1466297676 358 VLFRF 362
Cdd:cd04867    81 IHFKF 85
PRK09602 PRK09602
translation-associated GTPase; Reviewed
 1-358 3.02e-43

translation-associated GTPase; Reviewed


Pssm-ID: 236584 [Multi-domain]  Cd Length: 396  Bit Score: 154.20  E-value: 3.02e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   1 MKLGMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGI--VSVP------DERLDKLAEMYHP-VKFTPatLEFVDI 71
Cdd:PRK09602    2 ITIGLVGKPNVGKSTFFNAATLADVEIANYPFTTIDPNVGVayVRVEcpckelGVKCNPRNGKCIDgTRFIP--VELIDV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  72 AGLVKGASKGEGLGNKFLSNIREVDAIVHVVrcfD-----DPNIIHVD-GSINPRRDIETIDLELI--FSDVelIERKLD 143
Cdd:PRK09602   80 AGLVPGAHEGRGLGNQFLDDLRQADALIHVV---DasgstDEEGNPVEpGSHDPVEDIKFLEEELDmwIYGI--LEKNWE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 144 R-TKKAMKGDKSLASAVefLEKL------KEH-----LESGKPARSYDMTEDELEILKETPLLSLKPVIYAANLCE-DDF 210
Cdd:PRK09602  155 KfSRKAQAEKFDIEEAL--AEQLsglginEEHvkealRELGLPEDPSKWTDEDLLELARELRKISKPMVIAANKADlPPA 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 211 RNNIEsnehykevcEIAKAEGSAVFPICAQIE------AE---------------ISDMDDEDKE--MFLADLgLETSG- 266
Cdd:PRK09602  233 EENIE---------RLKEEKYYIVVPTSAEAElalrraAKaglidyipgdsdfeiLGELSEKQKKalEYIREV-LKKYGg 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 267 ------LNRIIkegYSLLGLI--------SYLTAGEPEV--RAWTIKKGTKAPQAAGKIHTDFEKGFIRAevvsfddlms 330
Cdd:PRK09602  303 tgvqeaINTAV---FDLLDMIvvypvedeNKLTDKKGNVlpDAFLLPKGSTARDLAYKIHTDIGEGFLYA---------- 369

                         410       420
                  ....*....|....*....|....*...
gi 1466297676 331 cgsmTAAKEKglVRLeGKDYVMQDGDIV 358
Cdd:PRK09602  370 ----IDARTK--RRI-GEDYELKDGDVI 390
Ygr210 cd01899
Ygr210 GTPase; Ygr210 is a member of Obg-like family and present in archaea and fungi. They ...
 3-223 1.93e-35

Ygr210 GTPase; Ygr210 is a member of Obg-like family and present in archaea and fungi. They are characterized by a distinct glycine-rich motif immediately following the Walker B motif. The Ygr210 and YyaF/YchF subfamilies appear to form one major branch of the Obg-like family. Among eukaryotes, the Ygr210 subfamily is represented only in fungi. These fungal proteins form a tight cluster with their archaeal orthologs, which suggests the possibility of horizontal transfer from archaea to fungi.


Pssm-ID: 206686 [Multi-domain]  Cd Length: 318  Bit Score: 131.58  E-value: 1.93e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   3 LGMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDE----RLDKLAE----------MYHPVkftpatlEF 68
Cdd:cd01899     1 IGLVGKPNVGKSTFFNAATLADVEIANYPFTTIDPNVGVGYVRVEcpckELGVSCNprygkcidgkRYVPV-------EL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  69 VDIAGLVKGASKGEGLGNKFLSNIREVDAIVHVVrcfD-----DPNIIHVD-GSINPRRDIETIDLELI--FSDVelIER 140
Cdd:cd01899    74 IDVAGLVPGAHEGKGLGNQFLDDLRDADVLIHVV---DasggtDAEGNGVEtGGYDPLEDIEFLENEIDmwIYGI--LER 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 141 KLDRT-KKAMKGDKSLASAVefLEKL----------KEHLESGK-PARSYDMTEDEL-----EILKETpllslKPVIYAA 203
Cdd:cd01899   149 NWEKIvRKAKAEKTDIVEAL--SEQLsgfgvnedvvIEALEELElPADLSKWDDEDLlrlarELRKRR-----KPMVIAA 221

                         250       260
                  ....*....|....*....|....
gi 1466297676 204 N----LCEDDFRNNIESNEHYKEV 223
Cdd:cd01899   222 NkadiPDAEENISKLRLKYPDEIV 245
Obg_like cd01881
Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; ...
 4-278 1.15e-32

Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; The Obg-like subfamily consists of five well-delimited, ancient subfamilies, namely Obg, DRG, YyaF/YchF, Ygr210, and NOG1. Four of these groups (Obg, DRG, YyaF/YchF, and Ygr210) are characterized by a distinct glycine-rich motif immediately following the Walker B motif (G3 box). Obg/CgtA is an essential gene that is involved in the initiation of sporulation and DNA replication in the bacteria Caulobacter and Bacillus, but its exact molecular role is unknown. Furthermore, several OBG family members possess a C-terminal RNA-binding domain, the TGS domain, which is also present in threonyl-tRNA synthetase and in bacterial guanosine polyphosphatase SpoT. Nog1 is a nucleolar protein that might function in ribosome assembly. The DRG and Nog1 subfamilies are ubiquitous in archaea and eukaryotes, the Ygr210 subfamily is present in archaea and fungi, and the Obg and YyaF/YchF subfamilies are ubiquitous in bacteria and eukaryotes. The Obg/Nog1 and DRG subfamilies appear to form one major branch of the Obg family and the Ygr210 and YchF subfamilies form another branch. No GEFs, GAPs, or GDIs for Obg have been identified.


Pssm-ID: 206668 [Multi-domain]  Cd Length: 167  Bit Score: 119.81  E-value: 1.15e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   4 GMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDerldklaemyhpvkftPATLEFVDIAGLVKGASKGEG 83
Cdd:cd01881     1 GLVGLPNVGKSTLLSALTSAKVEIASYPFTTLEPNVGVFEFGD----------------GVDIQIIDLPGLLDGASEGRG 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  84 LGNKFLSNIREVDAIVHVVRCFDDPniihvdgSINPRRDIETIdlelifsDVELIERKLDRTkkamkgdkslasavefle 163
Cdd:cd01881    65 LGEQILAHLYRSDLILHVIDASEDC-------VGDPLEDQKTL-------NEEVSGSFLFLK------------------ 112

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 164 klkehlesgkparsydmtedeleilketpllsLKPVIYAANLCEDDFRNNIesnehyKEVCEIAKAEGSAVFPICAQIEa 243
Cdd:cd01881   113 --------------------------------NKPEMIVANKIDMASENNL------KRLKLDKLKRGIPVVPTSALTR- 153

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1466297676 244 eisdmddedkemfladlgletSGLNRIIKEGYSLL 278
Cdd:cd01881   154 ---------------------LGLDRVIRTIRKLL 167
Obg cd01898
Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress ...
 3-141 5.09e-28

Obg GTPase; The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins conserved from bacteria to humans. The E. coli homolog, ObgE is believed to function in ribosomal biogenesis. Members of the subfamily contain two equally and highly conserved domains, a C-terminal GTP binding domain and an N-terminal glycine-rich domain.


Pssm-ID: 206685 [Multi-domain]  Cd Length: 170  Bit Score: 107.51  E-value: 5.09e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   3 LGMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERldklaemyhpvKFTpatleFVDIAGLVKGASKGE 82
Cdd:cd01898     3 VGLVGLPNAGKSTLLSAISNAKPKIADYPFTTLVPNLGVVRVDDGR-----------SFV-----IADIPGLIEGASEGK 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1466297676  83 GLGNKFLSNIREVDAIVHVVRCFDDPNIIHvdgsinprrDIETIDLELIFSDVELIERK 141
Cdd:cd01898    67 GLGHRFLRHIERTRVLLHVIDLSGEDDPVE---------DYETIRNELEAYNPGLAEKP 116
Obg_CgtA TIGR02729
Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome ...
 4-141 2.37e-26

Obg family GTPase CgtA; This model describes a univeral, mostly one-gene-per-genome GTP-binding protein that associates with ribosomal subunits and appears to play a role in ribosomal RNA maturation. This GTPase, related to the nucleolar protein Obg, is designated CgtA in bacteria. Mutations in this gene are pleiotropic, but it appears that effects on cellular functions such as chromosome partition may be secondary to the effect on ribosome structure. Recent work done in Vibrio cholerae shows an essential role in the stringent response, in which RelA-dependent ability to synthesize the alarmone ppGpp is required for deletion of this GTPase to be lethal. [Protein synthesis, Other]


Pssm-ID: 274271 [Multi-domain]  Cd Length: 328  Bit Score: 107.12  E-value: 2.37e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   4 GMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERldklaemyhpvkftpatlEFV--DIAGLVKGASKG 81
Cdd:TIGR02729 161 GLVGLPNAGKSTLISAVSAAKPKIADYPFTTLVPNLGVVRVDDGR------------------SFViaDIPGLIEGASEG 222

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  82 EGLGNKFLSNIREVDAIVHVVRCFDDpniihvDGSiNPRRDIETIDLELIFSDVELIERK 141
Cdd:TIGR02729 223 AGLGHRFLKHIERTRVLLHLIDISPE------DGS-DPVEDYEIIRNELKKYSPELAEKP 275
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 2-111 2.57e-26

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 101.16  E-value: 2.57e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   2 KLGMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERldklaemyhpvkftpatLEFVDIAGLVKGASKG 81
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVSDYPGTTRDPNEGRLELKGKQ-----------------IILVDTPGLIEGASEG 63

                          90       100       110
                  ....*....|....*....|....*....|
gi 1466297676  82 EGLGNKFLSnIREVDAIVHVVRCFDDPNII 111
Cdd:pfam01926  64 EGLGRAFLA-IIEADLILFVVDSEEGITPL 92
Obg COG0536
GTPase involved in cell partioning and DNA repair [Cell cycle control, cell division, ...
 4-167 4.76e-26

GTPase involved in cell partioning and DNA repair [Cell cycle control, cell division, chromosome partitioning, Replication, recombination, and repair];


Pssm-ID: 440302 [Multi-domain]  Cd Length: 343  Bit Score: 106.60  E-value: 4.76e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   4 GMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERldklaemyhpvkftpatlEFV--DIAGLVKGASKG 81
Cdd:COG0536   161 GLVGLPNAGKSTLLSAVSAAKPKIADYPFTTLVPNLGVVRVGDGR------------------SFViaDIPGLIEGASEG 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  82 EGLGNKFLSNIREVDAIVHVVRCFDDpniihvDGSiNPRRDIETIDLELIFSDVELIER-------KLDrtkkaMKGDKS 154
Cdd:COG0536   223 AGLGHRFLRHIERTRVLLHVVDAAPL------DGR-DPVEDYEIIRNELEAYSPELAEKprivvlnKID-----LLDAEE 290

                         170
                  ....*....|...
gi 1466297676 155 LASAVEFLEKLKE 167
Cdd:COG0536   291 LEELKAELEKLGG 303
obgE PRK12297
GTPase CgtA; Reviewed
 4-170 3.51e-25

GTPase CgtA; Reviewed


Pssm-ID: 237046 [Multi-domain]  Cd Length: 424  Bit Score: 105.57  E-value: 3.51e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   4 GMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERldklaemyhpvkftpatlEFV--DIAGLVKGASKG 81
Cdd:PRK12297  162 GLVGFPNVGKSTLLSVVSNAKPKIANYHFTTLVPNLGVVETDDGR------------------SFVmaDIPGLIEGASEG 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  82 EGLGNKFLsniRevdaivHVVRCFddpNIIHV-DGSI----NPRRDIETIDLELIFSDVELIER-------KLDrtkkam 149
Cdd:PRK12297  224 VGLGHQFL---R------HIERTR---VIVHViDMSGsegrDPIEDYEKINKELKLYNPRLLERpqivvanKMD------ 285

                         170       180
                  ....*....|....*....|.
gi 1466297676 150 kgdksLASAVEFLEKLKEHLE 170
Cdd:PRK12297  286 -----LPEAEENLEEFKEKLG 301
obgE PRK12299
GTPase CgtA; Reviewed
 4-141 7.45e-24

GTPase CgtA; Reviewed


Pssm-ID: 237048 [Multi-domain]  Cd Length: 335  Bit Score: 100.53  E-value: 7.45e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   4 GMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERldklaemyhpvkftpatlEFV--DIAGLVKGASKG 81
Cdd:PRK12299  162 GLVGLPNAGKSTLISAVSAAKPKIADYPFTTLHPNLGVVRVDDYK------------------SFViaDIPGLIEGASEG 223

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1466297676  82 EGLGNKFLSnirevdaivHVVRCfddpNI-IH-VDGS-INPRRDIETIDLELIFSDVELIERK 141
Cdd:PRK12299  224 AGLGHRFLK---------HIERT----RLlLHlVDIEaVDPVEDYKTIRNELEKYSPELADKP 273
obgE PRK12298
GTPase CgtA; Reviewed
 4-130 1.73e-20

GTPase CgtA; Reviewed


Pssm-ID: 237047 [Multi-domain]  Cd Length: 390  Bit Score: 91.47  E-value: 1.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   4 GMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERldklaemyhpvkftpatlEFV--DIAGLVKGASKG 81
Cdd:PRK12298  163 GLLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPNLGVVRVDDER------------------SFVvaDIPGLIEGASEG 224

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1466297676  82 EGLGNKFLSNIREVDAIVHVVrcfddpNIIHVDGSiNPRRDIETIDLEL 130
Cdd:PRK12298  225 AGLGIRFLKHLERCRVLLHLI------DIAPIDGS-DPVENARIIINEL 266
Rbg1 COG1163
Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];
5-358 4.73e-20

Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440777 [Multi-domain]  Cd Length: 368  Bit Score: 90.24  E-value: 4.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   5 MVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIvsvpderldklaemyhpVKFTPATLEFVDIAGLVKGASKGEGL 84
Cdd:COG1163    68 LVGFPSVGKSTLLNKLTNAKSEVGAYEFTTLDVVPGM-----------------LEYKGAKIQILDVPGLIEGAASGKGR 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  85 GNKFLSNIREVDAIVHVVRCFddpNIIHvdgsinprrdIETIDLELIFSDVELIERKLD-RTKKAMKGDKSLASAVEF-- 161
Cdd:COG1163   131 GKEVLSVVRNADLILIVLDVF---ELEQ----------YDVLKEELYDAGIRLNKPPPDvTIEKKGKGGIRVNSTGKLdl 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 162 -LEKLKEHLesgkpaRSY-----------DMTEDELE--ILKETpllSLKPVIYAANlceddfRNNIESNEHYKEVCEIA 227
Cdd:COG1163   198 dEEDIKKIL------REYgivnadvlireDVTLDDLIdaLMGNR---VYKPAIVVVN------KIDLADEEYVEELKSKL 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 228 KAEGSAVFpicaqieaeISdmddedkemflADLGLetsGLNRIIKEGYSLLGLIS-YL---TAGEPEVRAWTIKKGTKAP 303
Cdd:COG1163   263 PDGVPVIF---------IS-----------AEKGI---GLEELKEEIFEELGLIRvYLkppGGKADMEEPLILRKGSTVG 319

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1466297676 304 QAAGKIHTDFEKGFIRAEV----VSFDDlmscgsmtaaKEKGLvrlegkDYVMQDGDIV 358
Cdd:COG1163   320 DVCEKIHRDFVERFRYARVwgksAKHPG----------QRVGL------DHVLEDGDIV 362
obgE PRK12296
GTPase CgtA; Reviewed
 4-130 1.95e-18

GTPase CgtA; Reviewed


Pssm-ID: 237045 [Multi-domain]  Cd Length: 500  Bit Score: 86.46  E-value: 1.95e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   4 GMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERldklaemyhpvkFTPAtlefvDIAGLVKGASKGEG 83
Cdd:PRK12296  163 GLVGFPSAGKSSLISALSAAKPKIADYPFTTLVPNLGVVQAGDTR------------FTVA-----DVPGLIPGASEGKG 225

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1466297676  84 LGNKFLSNIREVDAIVHVVRCfddpniihvdGSINPRR----DIETIDLEL 130
Cdd:PRK12296  226 LGLDFLRHIERCAVLVHVVDC----------ATLEPGRdplsDIDALEAEL 266
DRG cd01896
Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding ...
 4-108 1.69e-16

Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding protein (DRG) subfamily is an uncharacterized member of the Obg family, an evolutionary branch of GTPase superfamily proteins. GTPases act as molecular switches regulating diverse cellular processes. DRG2 and DRG1 comprise the DRG subfamily in eukaryotes. In view of their widespread expression in various tissues and high conservation among distantly related species in eukaryotes and archaea, DRG proteins may regulate fundamental cellular processes. It is proposed that the DRG subfamily proteins play their physiological roles through RNA binding.


Pssm-ID: 206683 [Multi-domain]  Cd Length: 233  Bit Score: 77.59  E-value: 1.69e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   4 GMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVsvpderldklaeMYHPVKftpatLEFVDIAGLVKGASKGEG 83
Cdd:cd01896     4 ALVGFPSVGKSTLLSKLTNTKSEVAAYEFTTLTCVPGVM------------EYKGAK-----IQLLDLPGIIEGASDGKG 66

                          90       100
                  ....*....|....*....|....*
gi 1466297676  84 LGNKFLSNIREVDAIVHVVRCFDDP 108
Cdd:cd01896    67 RGRQVIAVARTADLILIVLDATKPE 91
TGS cd01616
TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold; ...
 283-361 5.90e-12

TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold; This family includes eukaryotic and some bacterial threonyl-tRNA synthetases (ThrRSs), a distinct Obg family GTPases, and guanosine polyphosphate hydrolase (SpoT) and synthetase (RelA), which are involved in stringent response in bacteria, as well as uridine kinase (UDK) from Thermotogales. All family members contain a TGS domain named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs. It is a small domain with a beta-grasp ubiquitin-like fold, a common structure involved in protein-protein interactions. The functions of the TGS domain remains unclear, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, with a regulatory role.


Pssm-ID: 340455 [Multi-domain]  Cd Length: 61  Bit Score: 60.31  E-value: 5.90e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1466297676 283 YLTAGEPEVRAWTIKKGTKAPQAAGKIHTDFEKGFIRAEVVSfddlmscgsmtaakekglvRLEGKDYVMQDGDIVLFR 361
Cdd:cd01616     2 VFTVGKTPGTVFVMNKGATAYSCAMHLHEDYCRKSILALVDG-------------------QLWDMYYPLTKGDEIKFL 61
TGS_Obg cd04938
TGS (ThrRS, GTPase and SpoT) domain found in the Obg protein family; The Obg family of GTPases ...
 285-361 3.92e-11

TGS (ThrRS, GTPase and SpoT) domain found in the Obg protein family; The Obg family of GTPases function has been implicated in cellular processes as diverse as sporulation, stress response, control of DNA replication, and ribosome assembly. It consists of several subfamilies such as DRG and YchF with TGS domain. The TGS domain is named after the various RNA-binding multidomain ThrRS, GTPase, and SpoT/RelA proteins in which this domain occurs. The TGS domain of Obg-like GTPases such as those present in DRG (developmentally regulated GTP-binding protein), and GTP-binding proteins Ygr210 and YchF has a beta-grasp ubiquitin-like fold, a common structure involved in protein-protein interactions.


Pssm-ID: 340517 [Multi-domain]  Cd Length: 77  Bit Score: 58.61  E-value: 3.92e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1466297676 285 TAGEPEVRAWTIKKGTKAPQAAGKIHTDFEKGFIRAEVVsfddlmscgsmtaakekGLVRLEGKDYVMQDGDIVLFR 361
Cdd:cd04938    18 SGNSVFRDCVLVKKGTTVKDFANKIHTDLEKGFINAEGI-----------------GGRRLEGEDYILQDNDVVKFT 77
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 4-167 3.15e-10

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 58.41  E-value: 3.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   4 GMVGLPNVGKSTLFNALTNAG-AESANYPFCTIEPNVGIVSVPDERldklaemyhpvkftpaTLEFVDIAGLVKGASKGE 82
Cdd:cd00880     1 AIFGRPNVGKSSLLNALLGQNvGIVSPIPGTTRDPVRKEWELLPLG----------------PVVLIDTPGLDEEGGLGR 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  83 GLGNKFLSNIREVDAIVHVvrcfddpniihVDGSINPRRDIETIDLE--------LIFSDVELIERK------LDRTKKA 148
Cdd:cd00880    65 ERVEEARQVADRADLVLLV-----------VDSDLTPVEEEAKLGLLrergkpvlLVLNKIDLVPESeeeellRERKLEL 133

                         170       180
                  ....*....|....*....|..
gi 1466297676 149 MKGDKSLA-SAVEF--LEKLKE 167
Cdd:cd00880   134 LPDLPVIAvSALPGegIDELRK 155
FeoB cd01879
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) ...
 5-102 8.89e-10

Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 206667 [Multi-domain]  Cd Length: 159  Bit Score: 56.70  E-value: 8.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   5 MVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDErldklaemyhpvkftpaTLEFVDIAGL--VKGASKGE 82
Cdd:cd01879     2 LVGNPNVGKTTLFNALTGARQKVGNWPGVTVEKKEGEFKLGGK-----------------EIEIVDLPGTysLTPYSEDE 64

                          90       100
                  ....*....|....*....|
gi 1466297676  83 GLGNKFLSNiREVDAIVHVV 102
Cdd:cd01879    65 KVARDFLLG-EEPDLIVNVV 83
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 6-141 1.98e-08

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 53.23  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   6 VGLPNVGKSTLFNALTNA-GAESANYPFCTIEPNVGIVSVPDERLDklaemyhpvkftpatLEFVDIAGLVKGasKGEGL 84
Cdd:cd00882     3 VGRGGVGKSSLLNALLGGeVGEVSDVPGTTRDPDVYVKELDKGKVK---------------LVLVDTPGLDEF--GGLGR 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1466297676  85 GNKFLSNIREVDAIVHVVRCFDDPNIIHVDGSINPRRDIETIDLELIFSDVELIERK 141
Cdd:cd00882    66 EELARLLLRGADLILLVVDSTDRESEEDAKLLILRRLRKEGIPIILVGNKIDLLEER 122
FeoB COG0370
Fe2+ transporter FeoB [Inorganic ion transport and metabolism];
1-49 3.44e-08

Fe2+ transporter FeoB [Inorganic ion transport and metabolism];


Pssm-ID: 440139 [Multi-domain]  Cd Length: 662  Bit Score: 55.13  E-value: 3.44e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1466297676   1 MKLGMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERL 49
Cdd:COG0370     4 ITIALVGNPNVGKTTLFNALTGSRQKVGNWPGVTVEKKEGKFKLKGKEI 52
FeoB_N pfam02421
Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) ...
 2-50 2.71e-07

Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 460552 [Multi-domain]  Cd Length: 156  Bit Score: 49.76  E-value: 2.71e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1466297676   2 KLGMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDERLD 50
Cdd:pfam02421   2 TIALVGNPNVGKTTLFNALTGANQHVGNWPGVTVEKKEGKFKYKGYEIE 50
feoB TIGR00437
ferrous iron transporter FeoB; FeoB (773 amino acids in E. coli), a cytoplasmic membrane ...
 7-102 3.15e-07

ferrous iron transporter FeoB; FeoB (773 amino acids in E. coli), a cytoplasmic membrane protein required for iron(II) update, is encoded in an operon with FeoA (75 amino acids), which is also required, and is regulated by Fur. There appear to be two copies in Archaeoglobus fulgidus and Clostridium acetobutylicum. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273077 [Multi-domain]  Cd Length: 591  Bit Score: 52.05  E-value: 3.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   7 GLPNVGKSTLFNALTNAGAESANYPFCTIEpnvgivsvpderldkLAEMYhpVKFTPATLEFVDIAGL--VKGASKGEGL 84
Cdd:TIGR00437   1 GNPNVGKSTLFNALTGANQTVGNWPGVTVE---------------KKEGK--LGFQGEDIEIVDLPGIysLTTFSLEEEV 63

                          90
                  ....*....|....*...
gi 1466297676  85 GNKFLSNiREVDAIVHVV 102
Cdd:TIGR00437  64 ARDYLLN-EKPDLVVNVV 80
NOG cd01897
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in ...
 7-40 3.32e-07

Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in eukaryotes ranging from trypanosomes to humans. NOG1 is functionally linked to ribosome biogenesis and found in association with the nuclear pore complexes and identified in many preribosomal complexes. Thus, defects in NOG1 can lead to defects in 60S biogenesis. The S. cerevisiae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function. It is a member of the ODN family of GTP-binding proteins that also includes the bacterial Obg and DRG proteins.


Pssm-ID: 206684 [Multi-domain]  Cd Length: 167  Bit Score: 49.48  E-value: 3.32e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1466297676   7 GLPNVGKSTLFNALTNAGAESANYPFCTIEPNVG 40
Cdd:cd01897     7 GYPNVGKSSLVNKLTRAKPEVAPYPFTTKSLFVG 40
Nog1 COG1084
GTP-binding protein, GTP1/Obg family [General function prediction only];
7-48 5.10e-07

GTP-binding protein, GTP1/Obg family [General function prediction only];


Pssm-ID: 440701 [Multi-domain]  Cd Length: 330  Bit Score: 50.99  E-value: 5.10e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1466297676   7 GLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDER 48
Cdd:COG1084   167 GYPNVGKSSLVSKVTSAKPEIASYPFTTKGIIVGHFERGHGR 208
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
 1-103 5.43e-06

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 45.83  E-value: 5.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   1 MKLGMVGLPNVGKSTLFNALT-NAGAESANYPFCTiepnvgivsvpderlDKLAEMYHPVKFTPATLEFVDIAGLVKGAS 79
Cdd:TIGR00231   2 IKIVIVGHPNVGKSTLLNSLLgNKGSITEYYPGTT---------------RNYVTTVIEEDGKTYKFNLLDTAGQEDYDA 66

                          90       100
                  ....*....|....*....|....
gi 1466297676  80 KGEGLGNKFLSNIREVDAIVHVVR 103
Cdd:TIGR00231  67 IRRLYYPQVERSLRVFDIVILVLD 90
HflX COG2262
50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]; ...
 6-48 1.25e-05

50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441863 [Multi-domain]  Cd Length: 419  Bit Score: 46.62  E-value: 1.25e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1466297676   6 VGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDER 48
Cdd:COG2262   205 VGYTNAGKSTLFNRLTGADVLAEDKLFATLDPTTRRLELPDGR 247
HflX cd01878
HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment ...
 6-48 1.55e-05

HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual biological functions of these GTPases remain unclear. HflX is widespread, but not universally represented in all three superkingdoms.


Pssm-ID: 206666 [Multi-domain]  Cd Length: 204  Bit Score: 45.14  E-value: 1.55e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1466297676   6 VGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPDER 48
Cdd:cd01878    47 VGYTNAGKSTLFNALTGADVLAEDQLFATLDPTTRRIKLPGGR 89
trmE PRK05291
tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;
6-171 3.93e-05

tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE;


Pssm-ID: 235392 [Multi-domain]  Cd Length: 449  Bit Score: 45.10  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   6 VGLPNVGKSTLFNALtnAGAESAnypfctiepnvgIVSvpDE----RlDKLAEMYH----PVKftpatleFVDIAGLVKG 77
Cdd:PRK05291  221 AGRPNVGKSSLLNAL--LGEERA------------IVT--DIagttR-DVIEEHINldgiPLR-------LIDTAGIRET 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  78 ASKGEGLG-NKFLSNIREVDAIVHVvrcfddpniihVDGSINPRRDIETIDLELIFSDVELIERKLDRTKKAMKGDKSLA 156
Cdd:PRK05291  277 DDEVEKIGiERSREAIEEADLVLLV-----------LDASEPLTEEDDEILEELKDKPVIVVLNKADLTGEIDLEEENGK 345

                         170       180
                  ....*....|....*....|..
gi 1466297676 157 SAVEF-------LEKLKEHLES 171
Cdd:PRK05291  346 PVIRIsaktgegIDELREAIKE 367
YlqF cd01856
Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs ...
 6-31 8.22e-05

Circularly permuted YlqF GTPase; Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The YlqF subfamily is represented in all eukaryotes as well as a phylogenetically diverse array of bacteria (including gram-positive bacteria, proteobacteria, Synechocystis, Borrelia, and Thermotoga).


Pssm-ID: 206749 [Multi-domain]  Cd Length: 171  Bit Score: 42.52  E-value: 8.22e-05
                          10        20
                  ....*....|....*....|....*..
gi 1466297676   6 VGLPNVGKSTLFNALTNAG-AESANYP 31
Cdd:cd01856   121 VGIPNVGKSTLINRLRGKKvAKVGNKP 147
EngA2 cd01895
EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second ...
 1-102 1.32e-04

EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206682 [Multi-domain]  Cd Length: 174  Bit Score: 42.03  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   1 MKLGMVGLPNVGKSTLFNALTnaGAESA---NYPFCTIEPnvgiVSVPDERLDKlaemyhpvKFTpatleFVDIAGLVKG 77
Cdd:cd01895     3 IKIAIIGRPNVGKSSLLNALL--GEERVivsDIAGTTRDS----IDVPFEYDGQ--------KYT-----LIDTAGIRKK 63

                          90       100
                  ....*....|....*....|....*..
gi 1466297676  78 ASKGEGLgnKFLSNIREVDAI--VHVV 102
Cdd:cd01895    64 GKVTEGI--EKYSVLRTLKAIerADVV 88
EngA1 cd01894
EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first ...
 6-21 2.72e-04

EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206681 [Multi-domain]  Cd Length: 157  Bit Score: 40.88  E-value: 2.72e-04
                          10
                  ....*....|....*.
gi 1466297676   6 VGLPNVGKSTLFNALT 21
Cdd:cd01894     3 VGRPNVGKSTLFNRLT 18
trmE cd04164
trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in ...
 6-171 2.97e-04

trmE is a tRNA modification GTPase; TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase domain that forms a canonical Ras-like fold. It functions a molecular switch GTPase, and apparently uses a conformational change associated with GTP hydrolysis to promote the tRNA modification reaction, in which the conserved cysteine in the C-terminal domain is thought to function as a catalytic residue. In bacteria that are able to survive in extremely low pH conditions, TrmE regulates glutamate-dependent acid resistance.


Pssm-ID: 206727 [Multi-domain]  Cd Length: 159  Bit Score: 40.94  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   6 VGLPNVGKSTLFNALtnAGAESAnypfctiepnvgIVSvpDE----RlDKLAEMY----HPVKftpatleFVDIAGLVKG 77
Cdd:cd04164     9 AGKPNVGKSSLLNAL--AGRDRA------------IVS--DIagttR-DVIEEEIdlggIPVR-------LIDTAGLRET 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  78 ASKGEGLG-NKFLSNIREVDAIVHVVrcfdDPNIIHVDGSINPRRDIETIDLELIFSDVELIERKLDRTKKAMKGDKSLa 156
Cdd:cd04164    65 EDEIEKIGiERAREAIEEADLVLLVV----DASEGLDEEDLEILELPAKKPVIVVLNKSDLLSDAEGISELNGKPIIAI- 139

                         170
                  ....*....|....*..
gi 1466297676 157 SAV--EFLEKLKEHLES 171
Cdd:cd04164   140 SAKtgEGIDELKEALLE 156
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
6-21 3.24e-04

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 42.32  E-value: 3.24e-04
                          10
                  ....*....|....*.
gi 1466297676   6 VGLPNVGKSTLFNALT 21
Cdd:COG1160     8 VGRPNVGKSTLFNRLT 23
PRK11058 PRK11058
GTPase HflX; Provisional
 3-46 3.38e-04

GTPase HflX; Provisional


Pssm-ID: 182934 [Multi-domain]  Cd Length: 426  Bit Score: 42.40  E-value: 3.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1466297676   3 LGMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPD 46
Cdd:PRK11058  200 VSLVGYTNAGKSTLFNRITEARVYAADQLFATLDPTLRRIDVAD 243
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 6-21 3.88e-04

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 41.96  E-value: 3.88e-04
                          10
                  ....*....|....*.
gi 1466297676   6 VGLPNVGKSTLFNALT 21
Cdd:PRK00093    7 VGRPNVGKSTLFNRLT 22
feoB PRK09554
Fe(2+) transporter permease subunit FeoB;
1-46 4.97e-04

Fe(2+) transporter permease subunit FeoB;


Pssm-ID: 236563 [Multi-domain]  Cd Length: 772  Bit Score: 42.01  E-value: 4.97e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1466297676   1 MK---LGMVGLPNVGKSTLFNALTNAGAESANYPFCTIEPNVGIVSVPD 46
Cdd:PRK09554    1 MKkltIGLIGNPNSGKTTLFNQLTGARQRVGNWAGVTVERKEGQFSTTD 49
MnmE COG0486
tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal ...
 6-28 5.61e-04

tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE [Translation, ribosomal structure and biogenesis]; tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440253 [Multi-domain]  Cd Length: 448  Bit Score: 41.59  E-value: 5.61e-04
                          10        20
                  ....*....|....*....|...
gi 1466297676   6 VGLPNVGKSTLFNALtnAGAESA 28
Cdd:COG0486   219 VGRPNVGKSSLLNAL--LGEERA 239
GTPase_EngA TIGR03594
ribosome-associated GTPase EngA; EngA (YfgK, Der) is a ribosome-associated essential GTPase ...
 6-21 9.18e-04

ribosome-associated GTPase EngA; EngA (YfgK, Der) is a ribosome-associated essential GTPase with a duplication of its GTP-binding domain. It is broadly to universally distributed among bacteria. It appears to function in ribosome biogenesis or stability. [Protein synthesis, Other]


Pssm-ID: 274667 [Multi-domain]  Cd Length: 428  Bit Score: 40.90  E-value: 9.18e-04
                          10
                  ....*....|....*.
gi 1466297676   6 VGLPNVGKSTLFNALT 21
Cdd:TIGR03594   4 VGRPNVGKSTLFNRLT 19
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
 2-22 1.49e-03

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 40.42  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|.
gi 1466297676   2 KLGMVGLPNVGKSTLFNALTN 22
Cdd:PRK00093  175 KIAIIGRPNVGKSSLINALLG 195
YlqF_related_GTPase cd01849
Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, ...
 2-30 1.57e-03

Circularly permuted YlqF-related GTPases; These proteins are found in bacteria, eukaryotes, and archaea. They all exhibit a circular permutation of the GTPase signature motifs so that the order of the conserved G box motifs is G4-G5-G1-G2-G3, with G4 and G5 being permuted from the C-terminal region of proteins in the Ras superfamily to the N-terminus of YlqF-related GTPases.


Pssm-ID: 206746 [Multi-domain]  Cd Length: 146  Bit Score: 38.52  E-value: 1.57e-03
                          10        20
                  ....*....|....*....|....*....
gi 1466297676   2 KLGMVGLPNVGKSTLFNALTNAGAESANY 30
Cdd:cd01849    93 RVGVVGLPNVGKSSFINALLNKFKLKVGS 121
syh CHL00201
histidine-tRNA synthetase; Provisional
 115-224 1.83e-03

histidine-tRNA synthetase; Provisional


Pssm-ID: 164576 [Multi-domain]  Cd Length: 430  Bit Score: 39.88  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676 115 GSINPRRDIETIDLEL-IFSDVELIERKLDRTKKAMKGDKSL--ASAVEFLEKLKEHLESGKPARsydMTEDELEILKET 191
Cdd:CHL00201  134 GSIDARADTEVIHLAMqIFNELQVKNLILDINSIGKLEDRQSyqLKLVEYLSQYQDDLDTDSQNR---LYSNPIRILDSK 210

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1466297676 192 PLLSLKPVIYAANLceDDFRnNIESNEHYKEVC 224
Cdd:CHL00201  211 NLKTQEILDGAPKI--SDFL-SLESTEHFYDVC 240
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
1-22 2.22e-03

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 39.62  E-value: 2.22e-03
                          10        20
                  ....*....|....*....|..
gi 1466297676   1 MKLGMVGLPNVGKSTLFNALTN 22
Cdd:COG1160   176 IKIAIVGRPNVGKSSLINALLG 197
HSR1_MMR1 cd01857
A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC ...
 3-20 3.73e-03

A circularly permuted subfamily of the Ras GTPases; Human HSR1 is localized to the human MHC class I region and is highly homologous to a putative GTP-binding protein, MMR1 from mouse. These proteins represent a new subfamily of GTP-binding proteins that has only eukaryote members. This subfamily shows a circular permutation of the GTPase signature motifs so that the C-terminal strands 5, 6, and 7 (strand 6 contains the G4 box with sequence NKXD) are relocated to the N-terminus.


Pssm-ID: 206750 [Multi-domain]  Cd Length: 140  Bit Score: 37.21  E-value: 3.73e-03
                          10
                  ....*....|....*...
gi 1466297676   3 LGMVGLPNVGKSTLFNAL 20
Cdd:cd01857    85 IGLVGYPNVGKSSLINAL 102
MnmE_helical pfam12631
MnmE helical domain; The tRNA modification GTPase MnmE consists of three domains. An ...
 6-22 4.69e-03

MnmE helical domain; The tRNA modification GTPase MnmE consists of three domains. An N-terminal domain, a helical domain and a GTPase domain which is nested within the helical domain. This family represents the helical domain.


Pssm-ID: 463649 [Multi-domain]  Cd Length: 326  Bit Score: 38.62  E-value: 4.69e-03
                          10
                  ....*....|....*..
gi 1466297676   6 VGLPNVGKSTLFNALTN 22
Cdd:pfam12631 100 VGKPNVGKSSLLNALLG 116
era TIGR00436
GTP-binding protein Era; Era is an essential GTPase in Escherichia coli and many other ...
 2-197 4.71e-03

GTP-binding protein Era; Era is an essential GTPase in Escherichia coli and many other bacteria. It plays a role in ribosome biogenesis. Few bacteria lack this protein. [Protein synthesis, Other]


Pssm-ID: 129528 [Multi-domain]  Cd Length: 270  Bit Score: 38.14  E-value: 4.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676   2 KLGMVGLPNVGKSTLFNALTNAgaesanypfctiepNVGIVS-VPDERLDKLAEmyhpVKFTPATLE-FVDIAGLVKGAS 79
Cdd:TIGR00436   2 FVAILGRPNVGKSTLLNQLHGQ--------------KISITSpKAQTTRNRISG----IHTTGASQIiFIDTPGFHEKKH 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1466297676  80 KGEGLGNKFLSN-IREVDAIVHVVRCFDDPNI------------IHVDGSINPRRDIETIDLELIFSDVELIERKLDRTK 146
Cdd:TIGR00436  64 SLNRLMMKEARSaIGGVDLILFVVDSDQWNGDgefvltklqnlkRPVVLTRNKLDNKFKDKLLPLIDKYAILEDFKDIVP 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1466297676 147 -KAMKGDKSLasavEFLEKLKEHLESG---KPARSYDMTEDE---LEILKETPLLSLK 197
Cdd:TIGR00436 144 iSALTGDNTS----FLAAFIEVHLPEGpfrYPEDYVTDQPDRfkiSEIIREKIIRYTK 197
GTPase_YlqF TIGR03596
ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding ...
 6-31 7.62e-03

ribosome biogenesis GTP-binding protein YlqF; Members of this protein family are GTP-binding proteins involved in ribosome biogenesis, including the essential YlqF protein of Bacillus subtilis, which is an essential protein. They are related to Era, EngA, and other GTPases of ribosome biogenesis, but are circularly permuted. This family is not universal, and is not present in Escherichia coli, and so is not as well studied as some other GTPases. This model is built for bacterial members. [Protein synthesis, Other]


Pssm-ID: 274669 [Multi-domain]  Cd Length: 276  Bit Score: 37.87  E-value: 7.62e-03
                          10        20
                  ....*....|....*....|....*..
gi 1466297676   6 VGLPNVGKSTLFNALTN-AGAESANYP 31
Cdd:TIGR03596 124 VGIPNVGKSTLINRLAGkKVAKVGNRP 150
Era cd04163
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is ...
 6-20 8.03e-03

E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly by chaperoning the 16S rRNA. It also contacts several assembly elements of the 30S subunit. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Homologs have also been found in eukaryotes. Era contains two domains: the N-terminal GTPase domain and a C-terminal domain KH domain that is critical for RNA binding. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA.


Pssm-ID: 206726 [Multi-domain]  Cd Length: 168  Bit Score: 36.67  E-value: 8.03e-03
                          10
                  ....*....|....*
gi 1466297676   6 VGLPNVGKSTLFNAL 20
Cdd:cd04163     9 IGRPNVGKSTLLNAL 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH