|
Name |
Accession |
Description |
Interval |
E-value |
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
2-494 |
1.87e-110 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 334.56 E-value: 1.87e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 2 NTQSQKVSMAEKIGYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKY 81
Cdd:COG2211 1 TAAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 82 RPWVLWTALPFMVFYVLAFYNPGIEDKGLVAlYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRFVAATIA 161
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSPTGKLI-YALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 162 QFVVQGLTLPLVSKFsdGGDKAHGWLCTISLFACIGFVFLVITFFSTRERIePPASQKTDTRQDIKDVFGSVPWRAMFIL 241
Cdd:COG2211 160 GLLASVLPPPLVAAF--GGDAALGYRLTALIFAVLGLLAFLLTFFGTKERP-VPEEEKVSLKESLKALLKNRPFLLLLLA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 242 TLFIFITLAMWGSAMNYYFENYVDAGALYafldrlglvametdgsagyavlnafglvvnssdkayevgFGVFNMLGALVQ 321
Cdd:COG2211 237 YLLFFLALALVAALLLYYFKYVLGLSAAL---------------------------------------VGLLLALYFLAA 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 322 FFGVIlLSGFLANRYGKKRVFIVCLSLTAIFTALFYFPGKADVETMFVLNFLKSLAYAPTVPLLWAMIADVADYSEYKNY 401
Cdd:COG2211 278 LLGAP-LWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTG 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 402 RRATGFVFAGVVFALKAGLGIGGAILGFLLSGFGYVSgiGAEQSGTAIRGIVLSSSLIPAMIFGMGVAALCFYPITKKYN 481
Cdd:COG2211 357 RRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVA--GAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERH 434
|
490
....*....|...
gi 1467206168 482 EQMQAELADRRSK 494
Cdd:COG2211 435 AEIRAELAARRAA 447
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
13-478 |
3.06e-94 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 292.20 E-value: 3.06e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 13 KIGYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKYRPWVLWTALPF 92
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 93 MVFYVLAFYNPGIEDKGLVAlYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRFVAATIAQFVVQGLTLPL 172
Cdd:cd17332 81 ALLFVLLFTTPDGSGTGKLI-YALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 173 VSKFSdGGDKAHGWLCTISLFACIGFVFLVITFFSTRERIEPPASQKTDT--RQDIKDVFGSVPWRAMFILTLFIFITLA 250
Cdd:cd17332 160 VAYFG-GGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLplLKSLKALLKNRPFLILLLAYLLYFLAFN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 251 MWGSAMNYYFEnYVDAGALYAFLdrlglvametdgsagyaVLNAFGLVvnssdkayevgfgvfnmlgalvqFFGVILLSG 330
Cdd:cd17332 239 IVNTVLVYYFK-YVLGGRAELVL-----------------LLLLILSG-----------------------ALLALLPWP 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 331 FLANRYGKKRVFIVCLSLTAIFTALFYFPGKADVETMFVLNFLKSLAYAPTVPLLWAMIADVADYSEYKNYRRATGFVFA 410
Cdd:cd17332 278 PLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYS 357
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1467206168 411 GVVFALKAGLGIGGAILGFLLSGFGYVSGIgAEQSGTAIRGIVLSSSLIPAMIFGMGVAALCFYPITK 478
Cdd:cd17332 358 VMTFFRKLGLALAGALVGLILSLAGYVANA-AAQSASALNGIRLLIAVLPAVLLLLALILMSFYPLDK 424
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
13-491 |
1.75e-87 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 275.28 E-value: 1.75e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 13 KIGYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKYRPWVLWTALPF 92
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 93 MVFYVLAFYNPGIEDKGLVAlYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRFVAATIAQFVVQGLTLPL 172
Cdd:TIGR00792 81 SIVLVLLFTTPDFSGTGKLV-YAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 173 VSKFSdGGDKAHGWLCTISLFACIGFVFLVITFFSTRERIEPPASQKTDT---RQDIKDVFGSVPWRAMFILTLFIFITL 249
Cdd:TIGR00792 160 VSYFG-GGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEIPKNIEKKlslKQIFKALFKNDQLLILCLAYLFYNLAF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 250 AMWGSAMNYYFENYVDAGALYAFldrlglvametdgsagyavlnafglvvnssdkayevgFGVFNMLGALVqffGVILLS 329
Cdd:TIGR00792 239 NIKNGVQVYYFTYVLGDPELFSY-------------------------------------MGSIAIVAGLI---GVLLFP 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 330 gFLANRYGKKRVFIVCLSLTAIFTALFYFPGKADVeTMFVLNFLKSLAYAPTVPLLWAMIADVADYSEYKNYRRATGFVF 409
Cdd:TIGR00792 279 -RLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLP-LILVLIILAGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVY 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 410 AGVVFALKAGLGIGGAILGFLLSGFGYVSgiGAEQSGTAIRGIVLSSSLIPAMIFGMG-VAALCFYPITKKYNEQMQAEL 488
Cdd:TIGR00792 357 SVRTFVRKLGQALAGFFVGLILGIIGYVA--NAAQSPITLNGIKILMFAVPALFLLLAaIIIGRFYKLTEKKHAEIVEEL 434
|
...
gi 1467206168 489 ADR 491
Cdd:TIGR00792 435 EQR 437
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
5-489 |
7.17e-86 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 271.21 E-value: 7.17e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 5 SQKVSMAEKIGYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKYRPW 84
Cdd:PRK09669 3 TSQLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFRPY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 85 VLWTALPFMVFYVLAFYNPGIEDKGLVAlYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRFVAATIAQFV 164
Cdd:PRK09669 83 LLWFAIPFGVVCLLTFYTPDFGATGKII-YACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 165 VQGLTLPLVSKFSDgGDKAHGWLCTISLFACIGFVFLVITFFSTRERIEPPASQKTDTRQDIKDVFGSVPWRAMFILTLF 244
Cdd:PRK09669 162 VSVIALPLVDILGK-GDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSSSVWKDLKLLLGNSQWRIMFIFNVV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 245 IFITLAMWGSAMNYYFeNYVdagalyafLDRLGLVametdgsagyavlnaFGLVVNSSdkayevgfgVFNMLGAlvqffg 324
Cdd:PRK09669 241 LLTAVVTRGGATLYYV-NYV--------LLRPDLA---------------TLFLVTGM---------IAGLFGA------ 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 325 viLLSGFLANRYGKKRVFIVCLSLTAIFTALFYFPGKADVETMFVLNFLKSLAYAPTVPLLWAMIADVADYSEYKNYRRA 404
Cdd:PRK09669 282 --LLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPPSNVWLIFALNILFNFIQNLTTPLQWSMFSDVVDYEEKRSGRRL 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 405 TGFVFAGVVFALKAGLGIGGAILGFLLSGFGYVSGiGAEQSGTAIRGIVLSSSLIPAMIFGMGVAALCFYPITKKYNEQM 484
Cdd:PRK09669 360 DGLVFSTNLFAIKLGLAIGGAVVGWILAWVDYVGG-AAVQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDARVEAI 438
|
....*
gi 1467206168 485 QAELA 489
Cdd:PRK09669 439 AQELV 443
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
15-478 |
3.83e-70 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 229.89 E-value: 3.83e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 15 GYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKYRPWVLWTALPFMV 94
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 95 FYVLAFYNPGIEDKGLVAlYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRFVAATIAQFVVQGLTLPLVS 174
Cdd:pfam13347 81 SFILLFTPPELGRAPLFI-WLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 175 KFSDGGDKAHGWLCTISLFACIGFVFLVITFFSTRERIE------PPASQKTDTRQDIKDVFGSVPWRAMFILTLFIFIT 248
Cdd:pfam13347 160 ILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSmrskedTGQKEAGSLLDMLKEVFRNRAFLILLASFLLAALA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 249 LAMWGSAMNYYFENYVDAGALYAFLDRLGLVAMetdgsagyavlnafglvvnssdkayevgfgvfnmlgalvqfFGVILL 328
Cdd:pfam13347 240 MGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGA-----------------------------------------LLGIPL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 329 SGFLANRYGKKRVFIVCLSLTAIFTALFYFPGKADVETMFVLNFLKSLAYAPTVPLLWAMIADVADYSEYKNYRRATGFV 408
Cdd:pfam13347 279 WPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKRREGTF 358
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 409 FAGVVFALKAGLGIGGAILGFLLSGFGYVSGIGAeQSGTAIRGIVLSSSLIPAMIFGMGVAALCFYPITK 478
Cdd:pfam13347 359 FAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSV-QSPQAVTAIRLLYAVLPAVLFLVALLLLYFYPLDR 427
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
2-494 |
1.87e-110 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 334.56 E-value: 1.87e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 2 NTQSQKVSMAEKIGYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKY 81
Cdd:COG2211 1 TAAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 82 RPWVLWTALPFMVFYVLAFYNPGIEDKGLVAlYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRFVAATIA 161
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSPTGKLI-YALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 162 QFVVQGLTLPLVSKFsdGGDKAHGWLCTISLFACIGFVFLVITFFSTRERIePPASQKTDTRQDIKDVFGSVPWRAMFIL 241
Cdd:COG2211 160 GLLASVLPPPLVAAF--GGDAALGYRLTALIFAVLGLLAFLLTFFGTKERP-VPEEEKVSLKESLKALLKNRPFLLLLLA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 242 TLFIFITLAMWGSAMNYYFENYVDAGALYafldrlglvametdgsagyavlnafglvvnssdkayevgFGVFNMLGALVQ 321
Cdd:COG2211 237 YLLFFLALALVAALLLYYFKYVLGLSAAL---------------------------------------VGLLLALYFLAA 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 322 FFGVIlLSGFLANRYGKKRVFIVCLSLTAIFTALFYFPGKADVETMFVLNFLKSLAYAPTVPLLWAMIADVADYSEYKNY 401
Cdd:COG2211 278 LLGAP-LWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTG 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 402 RRATGFVFAGVVFALKAGLGIGGAILGFLLSGFGYVSgiGAEQSGTAIRGIVLSSSLIPAMIFGMGVAALCFYPITKKYN 481
Cdd:COG2211 357 RRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVA--GAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERH 434
|
490
....*....|...
gi 1467206168 482 EQMQAELADRRSK 494
Cdd:COG2211 435 AEIRAELAARRAA 447
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
13-478 |
3.06e-94 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 292.20 E-value: 3.06e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 13 KIGYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKYRPWVLWTALPF 92
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 93 MVFYVLAFYNPGIEDKGLVAlYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRFVAATIAQFVVQGLTLPL 172
Cdd:cd17332 81 ALLFVLLFTTPDGSGTGKLI-YALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 173 VSKFSdGGDKAHGWLCTISLFACIGFVFLVITFFSTRERIEPPASQKTDT--RQDIKDVFGSVPWRAMFILTLFIFITLA 250
Cdd:cd17332 160 VAYFG-GGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLplLKSLKALLKNRPFLILLLAYLLYFLAFN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 251 MWGSAMNYYFEnYVDAGALYAFLdrlglvametdgsagyaVLNAFGLVvnssdkayevgfgvfnmlgalvqFFGVILLSG 330
Cdd:cd17332 239 IVNTVLVYYFK-YVLGGRAELVL-----------------LLLLILSG-----------------------ALLALLPWP 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 331 FLANRYGKKRVFIVCLSLTAIFTALFYFPGKADVETMFVLNFLKSLAYAPTVPLLWAMIADVADYSEYKNYRRATGFVFA 410
Cdd:cd17332 278 PLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYS 357
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1467206168 411 GVVFALKAGLGIGGAILGFLLSGFGYVSGIgAEQSGTAIRGIVLSSSLIPAMIFGMGVAALCFYPITK 478
Cdd:cd17332 358 VMTFFRKLGLALAGALVGLILSLAGYVANA-AAQSASALNGIRLLIAVLPAVLLLLALILMSFYPLDK 424
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
13-491 |
1.75e-87 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 275.28 E-value: 1.75e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 13 KIGYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKYRPWVLWTALPF 92
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 93 MVFYVLAFYNPGIEDKGLVAlYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRFVAATIAQFVVQGLTLPL 172
Cdd:TIGR00792 81 SIVLVLLFTTPDFSGTGKLV-YAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 173 VSKFSdGGDKAHGWLCTISLFACIGFVFLVITFFSTRERIEPPASQKTDT---RQDIKDVFGSVPWRAMFILTLFIFITL 249
Cdd:TIGR00792 160 VSYFG-GGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEIPKNIEKKlslKQIFKALFKNDQLLILCLAYLFYNLAF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 250 AMWGSAMNYYFENYVDAGALYAFldrlglvametdgsagyavlnafglvvnssdkayevgFGVFNMLGALVqffGVILLS 329
Cdd:TIGR00792 239 NIKNGVQVYYFTYVLGDPELFSY-------------------------------------MGSIAIVAGLI---GVLLFP 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 330 gFLANRYGKKRVFIVCLSLTAIFTALFYFPGKADVeTMFVLNFLKSLAYAPTVPLLWAMIADVADYSEYKNYRRATGFVF 409
Cdd:TIGR00792 279 -RLVKKFGRKILFAGGILLMVLGYLIFFFAGSNLP-LILVLIILAGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVY 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 410 AGVVFALKAGLGIGGAILGFLLSGFGYVSgiGAEQSGTAIRGIVLSSSLIPAMIFGMG-VAALCFYPITKKYNEQMQAEL 488
Cdd:TIGR00792 357 SVRTFVRKLGQALAGFFVGLILGIIGYVA--NAAQSPITLNGIKILMFAVPALFLLLAaIIIGRFYKLTEKKHAEIVEEL 434
|
...
gi 1467206168 489 ADR 491
Cdd:TIGR00792 435 EQR 437
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
5-489 |
7.17e-86 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 271.21 E-value: 7.17e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 5 SQKVSMAEKIGYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKYRPW 84
Cdd:PRK09669 3 TSQLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFRPY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 85 VLWTALPFMVFYVLAFYNPGIEDKGLVAlYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRFVAATIAQFV 164
Cdd:PRK09669 83 LLWFAIPFGVVCLLTFYTPDFGATGKII-YACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 165 VQGLTLPLVSKFSDgGDKAHGWLCTISLFACIGFVFLVITFFSTRERIEPPASQKTDTRQDIKDVFGSVPWRAMFILTLF 244
Cdd:PRK09669 162 VSVIALPLVDILGK-GDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSSSVWKDLKLLLGNSQWRIMFIFNVV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 245 IFITLAMWGSAMNYYFeNYVdagalyafLDRLGLVametdgsagyavlnaFGLVVNSSdkayevgfgVFNMLGAlvqffg 324
Cdd:PRK09669 241 LLTAVVTRGGATLYYV-NYV--------LLRPDLA---------------TLFLVTGM---------IAGLFGA------ 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 325 viLLSGFLANRYGKKRVFIVCLSLTAIFTALFYFPGKADVETMFVLNFLKSLAYAPTVPLLWAMIADVADYSEYKNYRRA 404
Cdd:PRK09669 282 --LLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPPSNVWLIFALNILFNFIQNLTTPLQWSMFSDVVDYEEKRSGRRL 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 405 TGFVFAGVVFALKAGLGIGGAILGFLLSGFGYVSGiGAEQSGTAIRGIVLSSSLIPAMIFGMGVAALCFYPITKKYNEQM 484
Cdd:PRK09669 360 DGLVFSTNLFAIKLGLAIGGAVVGWILAWVDYVGG-AAVQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDARVEAI 438
|
....*
gi 1467206168 485 QAELA 489
Cdd:PRK09669 439 AQELV 443
|
|
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
4-489 |
1.68e-78 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 252.94 E-value: 1.68e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 4 QSQKVSMAEKIGYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKYRP 83
Cdd:PRK11462 2 KSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 84 WVLWTALPFMVFYVLAFYNPGIEDKGLVaLYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRFVAATIAQF 163
Cdd:PRK11462 82 WVLFGALPFGIVCVLAYSTPDLSMNGKM-IYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 164 VVQGLTLPLVsKFSDGGDKAHGWLCTISLFACIGFVFLVITFFSTRERIEPPASQkTDTRQDIKDVFGSVPWRAMFILTL 243
Cdd:PRK11462 161 LSTVLMMPLV-NLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPPTT-TSMREDLRDIWQNDQWRIVGLLTI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 244 FIFITLAMWGSAMNYYFENYVDAGALY-AFLdrlglvametdgsAGYAVLNAFGLVVNSSDKAYEVGFGVFNMLGALvqf 322
Cdd:PRK11462 239 FNILAVCVRGGAMMYYVTWILGTPEVFvAFL-------------TTYCVGNLIGSALAKPLTDWKCKVTIFWWTNAL--- 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 323 fgvillsgflanrygkkrvfivclsLTAIFTALFYFPGKADVeTMFVLNFLKSLAYAPTVPLLWAMIADVADYSEYKNYR 402
Cdd:PRK11462 303 -------------------------LAVISLAMFFVPMQASI-TMFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGK 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 403 RATGFVFAGVVFALKAGLGIGGAILGFLLSGFGYVSGIGAEQSGTaIRGIVLSSSLIPAMIFGM-GVAALCFYPITKKYN 481
Cdd:PRK11462 357 RLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKAQNSAT-ISIIIALFTIVPAICYLLsAIIAKRYYSLTTHNL 435
|
....*...
gi 1467206168 482 EQMQAELA 489
Cdd:PRK11462 436 KTVMEQLA 443
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
15-478 |
3.83e-70 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 229.89 E-value: 3.83e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 15 GYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKYRPWVLWTALPFMV 94
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 95 FYVLAFYNPGIEDKGLVAlYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRFVAATIAQFVVQGLTLPLVS 174
Cdd:pfam13347 81 SFILLFTPPELGRAPLFI-WLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 175 KFSDGGDKAHGWLCTISLFACIGFVFLVITFFSTRERIE------PPASQKTDTRQDIKDVFGSVPWRAMFILTLFIFIT 248
Cdd:pfam13347 160 ILGGTGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSmrskedTGQKEAGSLLDMLKEVFRNRAFLILLASFLLAALA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 249 LAMWGSAMNYYFENYVDAGALYAFLDRLGLVAMetdgsagyavlnafglvvnssdkayevgfgvfnmlgalvqfFGVILL 328
Cdd:pfam13347 240 MGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGA-----------------------------------------LLGIPL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 329 SGFLANRYGKKRVFIVCLSLTAIFTALFYFPGKADVETMFVLNFLKSLAYAPTVPLLWAMIADVADYSEYKNYRRATGFV 408
Cdd:pfam13347 279 WPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKRREGTF 358
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 409 FAGVVFALKAGLGIGGAILGFLLSGFGYVSGIGAeQSGTAIRGIVLSSSLIPAMIFGMGVAALCFYPITK 478
Cdd:pfam13347 359 FAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSV-QSPQAVTAIRLLYAVLPAVLFLVALLLLYFYPLDR 427
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
5-495 |
2.65e-56 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 193.85 E-value: 2.65e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 5 SQKVSMAEKIGYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKYRPW 84
Cdd:PRK09848 2 NQQLSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRPF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 85 VLWTALPFMVFYVLAFYNPGIEDKGLVALYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRFVAATIAqFV 164
Cdd:PRK09848 82 LLFGTAPLMIFSVLVFWVPTDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLT-FV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 165 VQGLTLPLVSKFSDGGDKAHGWLCTISLFACIGFVFLVITFFSTRERIEPPASQKTdTRQDIKDVFGSVPWRAMFILTLF 244
Cdd:PRK09848 161 CLAFLIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVVRIVAQPS-LKISLQTLKRNRPLFMLCIGALC 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 245 IFI-TLAMWGSAMnyYFENYVdagalyafLDRLGLvametdgsagyavlnafglvvnssdkayevgFGVFNMLGALVQFF 323
Cdd:PRK09848 240 VLIsTFAVSASSL--FYVRYV--------LNDTGL-------------------------------FTVLVLVQNLVGTV 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 324 GVILLSGFLANRYGKKRVFIVCLSLTAIFTALFYFPGKADVETMFVLNFLKSLAYAPTVPLLWAMIADVADYSEYKNYRR 403
Cdd:PRK09848 279 ASAPLVPGMVARIGKKNTFLIGALLGTCGYLLFFWVSVWSLPVALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVR 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 404 ATGFVFAGVVFALKAGLGIGGAILGFLLSGFGYVSgiGAEQSGTAIRGIVLSSSLIPAMIFGMGVAALCFYPITKKYNEQ 483
Cdd:PRK09848 359 IEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIA--NQVQTPEVIMGIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKE 436
|
490
....*....|..
gi 1467206168 484 MQAELADRRSKA 495
Cdd:PRK09848 437 IVVEIDNRKKVQ 448
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
7-496 |
1.54e-31 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 126.75 E-value: 1.54e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 7 KVSMAEKIGYSLG----DCSANLVFQMMMIYqtkfYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKYR 82
Cdd:PRK10429 2 SISMTTKLSYGFGafgkDFAIGIVYMYLMYY----YTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTRSRWGKFK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 83 PWVLWTALPFMVFYVLAFYNPGIEDKGLVAlYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRFVAATIAQ 162
Cdd:PRK10429 78 PWILIGTLANSVVLFLLFSAHLFEGTAQYV-FVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASLAG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 163 FVVQGLTLPLVSKFSdGGDKAHGwlctISLFACIGFVFLVITFFSTRERIEPPASQKTDTRQDIKdvfgSVPWRAMFILT 242
Cdd:PRK10429 157 FVTAGFTLPFVNYVG-GGDRGFG----FQMFTLVLIAFFIVSTIITLRNVHEVYSSDNQVSAEGS----HLTLKDIVALI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 243 LFIFITLAMWGSAMNYYFENYVDAG-ALYAFLDRLGLVAMetdgsagyavlnafglvvnssdkayevgFGVFNMLGALVQ 321
Cdd:PRK10429 228 YKNDQLSCLLGMALAYNIASNIINGfAIYYFTYVIGDADL----------------------------FPYYLSYAGAAN 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 322 FFGVILLSgFLANRYGKKRVFIVCLSLTAIFTALFYFPGKADVETMF-------VLNFLKSLAYAPTVpllwAMIADVAD 394
Cdd:PRK10429 280 LVTLILFP-RLVKSLSRRILWAGASIFPVLSCGVLLLMGLAAPHNALliviagiLLNIGTALFWVLQV----IMVADTVD 354
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 395 YSEYKNYRRATGFVFAGVVFALKAGLGIGGAILGFLLSGFGYVSGIgaEQSGTAIRGIVLSSSLIPAMIFGM-GVAALCF 473
Cdd:PRK10429 355 YGEYKLGIRCESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGYVPNV--EQSAQTLLGMQFIMIGLPTLFFMItLVLYFRY 432
|
490 500
....*....|....*....|...
gi 1467206168 474 YPITKKYNEQMQAELADRRSKAG 496
Cdd:PRK10429 433 YRLNGDFLRRIQIHLLDKYRKVP 455
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
13-250 |
2.31e-12 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 68.65 E-value: 2.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 13 KIGYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTK-TRFGKYRPWVLWTaLP 91
Cdd:cd17392 1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQrTGIGRLMPWIVFS-TP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 92 FMVF-YVLAFYNPgiEDKGLVALYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRF---VAATIAQFVVQG 167
Cdd:cd17392 80 LIILaYFFLWFLP--PFTSLSGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRMtveVFGTLMGATIQG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 168 LTLPLVSK-----------FSDGG-----DKAHGWLCTISLFACIGFVFLVITFFSTRERIEPPASQKTDTR---QDIKD 228
Cdd:cd17392 158 QIVGVAHRprrqdctatpgTSDHPvtvlpNTRRAYLIAALVVVVLYFVCCSILFLGVKEQPDPLSPASGPGLsylAGLKL 237
|
250 260
....*....|....*....|..
gi 1467206168 229 VFGSVPWraMFILTLFIFITLA 250
Cdd:cd17392 238 VTGHPPY--LKLVIGFLFSSLA 257
|
|
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
35-478 |
1.18e-10 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 63.30 E-value: 1.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 35 TKFYTDIFGLEGAI-----AGTVMLVARITDAFVDPTVGLLSDRTK-TRFGKYRPWVLwTALPFMVF-YVLAFYNPGIED 107
Cdd:cd17452 18 TAFFLQIYLLDIAQitpfqASLVLFVGKAWGAATDPVVGFFISKSKwTKIGRLMPWML-GCTPFIVVsYFFLWFVPPFTT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 108 kgLVALYATLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRF---VAATIAQFVVQGLTLplvskfsdggdkAH 184
Cdd:cd17452 97 --GRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMtveVLGTLVGAAVQGQIV------------AS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 185 GWLCTISLFACIGFVFLVITFFSTRERIEP--PASQKtdtrqdikdvfgSVPWRAMFILTLfifitlamwgsamnyYFEN 262
Cdd:cd17452 163 AYMIAAGVIGGLYLLCISVLFLGVKERDDPyaPKSGK------------AIPFFKGLSLTM---------------RHGP 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 263 YVDAGALYAFLDrlglVAMETDGSagYAVLnafgLVVNSSDKAYEVGFGVFNMLGALVqfFGVILLSGFLaNRYGKKRVF 342
Cdd:cd17452 216 YLKLTASFLFIS----AAVQLEQS--NFVL----FCTHAVDLHDHFQNLVLTILVSAV--VSIPFWQWFL-QRFGKKAAA 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 343 IvCLSLTAIFTALFYFPGKADVEtmFVLNFLKSLAYAPTVPLLWAMIADVADYSEYKN-YRRATGFVF-AGVVFALKAGL 420
Cdd:cd17452 283 C-GISWMIPFAIMLVTIPNLIVA--YVVAFVSGLSIAASLLLPWSMLPDVVDDFRLQNpHGKGLETIFySSYVFFTKLSA 359
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1467206168 421 GIGGAILGFLLSGFGYVSGIgAEQSGTAIRGIVLSSSLIPAMIFGMGVAALCFYPITK 478
Cdd:cd17452 360 GIALGISTLSLEFAGYETGA-CKQPESVVLTLKLLIGAAPTCMILIGLCILMFYPITE 416
|
|
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
37-250 |
1.76e-10 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 62.91 E-value: 1.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 37 FYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTK-TRFGKYRPWVLWTALPFMVFYVLAFYNPGIeDKGLVALYa 115
Cdd:cd17451 25 YLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPwTRFGRLMPWIIFSTPFAVLSYFLIWFVPDF-SQGKVMWY- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 116 TLSYTLLMSLYSFNNTPYASLGGVMSGDIKERTSITSIRF---VAATIAQFVVQGLTLPLVSkfsdggdkahgWLCTISL 192
Cdd:cd17451 103 LLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMtveVLGTVLGTAIQGQIVGMAA-----------YMIAAGV 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1467206168 193 FACIGFVFLVITFFSTRERIEP---PASQKTDTRQDIKDVFGSVPWraMFILTLFIFITLA 250
Cdd:cd17451 172 ICAIYVLCAIILFLGVREQREPcelKSQKPVSFFKGLKLVMSHGPY--IKLITGFLFTSLA 230
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
13-225 |
1.44e-09 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 59.96 E-value: 1.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 13 KIGYSLGDCSANLVFQMMMIYQTKFYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRT--KTRFGKYRPWVLWTAL 90
Cdd:cd17491 1 RIAYGVGHVLNDLCASMWFTYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTngCGKYGRRKSWHLIGTI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 91 PFMVFYVLAFYNPGIEDKGLVALYATLSYTLLMSLYSFN----NTPYASLGGVMSGDIKERTSITSIRF---VAATIAQF 163
Cdd:cd17491 81 CVLLSFPFIFNPCLGCSDSTSEWAKLVYYGPFIIIFQFGwaavQISHLSLIPELTSDEHERVELTALRYaftVIANITVY 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1467206168 164 VVQGLTLplvsKFSDGGDKAHGWLCTISLF-------ACIGFVFLVITFFSTRERiEPPASQKTDTRQD 225
Cdd:cd17491 161 LIAWLLL----QQSSGDSVNPTSAQDLPIFrnlslivVGIGFLFSLLFHLGTKEP-RPPTDLSTTTNEG 224
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
42-358 |
3.76e-07 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 52.24 E-value: 3.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 42 FGLEGAIAGTVMLVARITDAFVDPTVGLLSDRTKTRFGKYRPWvLWTALPFMVFYVLAFYNPGIEDKGLVALYATLSYTL 121
Cdd:cd17313 29 LGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPF-ILVGAPLAALGLILIPNAADIGLALGDGPRTWALVL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 122 LMS----LYSFNNT---PYASLGGVMSGDIKERTSITSIRF---VAATIAQFVVQGLTLPLVSKFSDGGDKAhgWLCTIS 191
Cdd:cd17313 108 FVLgivlLDFAMNVcqgPVRALLPDLVPPEQRSKANGIINFmggLGGVLGYLLGAILWDHNWFGFALGGNLK--VPFYIG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 192 lfACIGFVFLVITFFSTRERIEPPASQKTDTRQDIKDVFGSVpWRAMFIL---TLFIFITLAMWGSAMNYYFENYVDAGA 268
Cdd:cd17313 186 --AIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSL-LKLLKIMprsLLRLLLVIFFWWIAFFPFELFFTDYMG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 269 LYAFLdrlGLVAMETDGSAGYAVlNAFGLVVNSsdkayeVGFGVFNmlgalvqffgviLLSGFLANRYGKKRVFIVCLSL 348
Cdd:cd17313 263 EEVYH---GTSAASSHYGAGVRM-GAWGLLIFS------LAFLIFS------------LPIGKLGKKIGRKKVYLIGLVL 320
|
330
....*....|
gi 1467206168 349 TAIFTALFYF 358
Cdd:cd17313 321 FAVGMALMAL 330
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-382 |
3.40e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.01 E-value: 3.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 37 FYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRtktrfgKYRPW-----VLWTALPFMVFYVLAFYnpgiedkGLV 111
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADR------KPRRYllplgPLLTGLGLSLLGFAPNY-------WLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 112 ALYATLSytllmslySFNNTPYASLGGVMSGDI--KERTSITSIRFVAATIAQFVVQGLTLPLVSKFsdgGDKAHGWLCT 189
Cdd:cd17478 88 LLLVALA--------GIGSAAFHPEGARLASQAagGRRGLAMSIFSVGGNLGFALGPLIAAALVALF---GGLGLLILLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 190 ISLFACIGFVFLVITFFSTRERIEPPASQKTDTRQDIkdvfgsvpWRAMFILTLFIFITLAMWGSAMNYYFENYVDAGAL 269
Cdd:cd17478 157 IPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGV--------WRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 270 YAFldrlglvametdgsAGYAVlnafglvvnssdkayevgfGVFNMLGALVQFFGvillsGFLANRYGKKRVFIVCLSLT 349
Cdd:cd17478 229 LVF--------------AGLLL-------------------SLFLFAGAIGTLIG-----GPLSDRFGRRRVIIASLLLA 270
|
330 340 350
....*....|....*....|....*....|....
gi 1467206168 350 AIFTALFYF-PGKADVETMFVLNFLKSLAYAPTV 382
Cdd:cd17478 271 APFLLLFLLtPGIWSYILLVLAGFLLFASFPVTV 304
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
315-385 |
1.19e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.36 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 315 MLGALVQFFgVILLSGFLANRYGKKRVFIVclslTAIFTALFYFPGKADVET----------MFVLNFLKSLAYAPTVPL 384
Cdd:cd17369 271 LIASVVAAI-TIPLFGWLSDRVGRRPVYLA----GALLAALFAFPFFWLLDTgstwlivlaaVVVLGVLHGMMYGPQAAF 345
|
.
gi 1467206168 385 L 385
Cdd:cd17369 346 L 346
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
311-415 |
1.30e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.11 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 311 GVFNMLGALVQFFGvILLSGFLANRYGKKRVFIVCLSLTAIFTALFYFPGkaDVETMFVLNFLKSLAYAPTVPLLWAMIA 390
Cdd:COG2814 48 GLVVTAYLLGAALG-APLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIA 124
|
90 100
....*....|....*....|....*
gi 1467206168 391 DVADyseYKNYRRATGFVFAGVVFA 415
Cdd:COG2814 125 DLVP---PERRGRALGLLGAGLGLG 146
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
311-410 |
1.80e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.66 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 311 GVFNMLGALVQFFGvILLSGFLANRYGKKRVFIVCLSLTAIFTALFYFPGKADVETMFVLNFLKSLAYAPTVPLLWAMIA 390
Cdd:cd17316 216 SLYLLLISLGALVG-ALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLA 294
|
90 100
....*....|....*....|
gi 1467206168 391 DVadyseYKNYRRATGFVFA 410
Cdd:cd17316 295 EL-----FPTEVRATGVGLS 309
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
37-393 |
4.02e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 4.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 37 FYTDIFGLEGAIAGTVMLVARITDAFVDPTVGLLSDRtktrFGKyRPWVLWTALPFMVFYVLAFYNPGIEdkGLVALYAt 116
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR----FGR-RRVLLLGLLLFALGSLLCALAPSLW--LLLAARF- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 117 lsytllmsLYSFNNTPYASLGGVMSGDI---KERTSITSIRFVAATIAQFVVQGLTLPLVSKFsdggdkahGWlctISLF 193
Cdd:COG2814 107 --------LQGLGAGALFPAALALIADLvppERRGRALGLLGAGLGLGPALGPLLGGLLADLF--------GW---RWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 194 ACIGFVFLVITFFSTRERIEPPASQKTDTRQDIKDVFGSVPWRAMFILTLFIFITLAMWGSAMNYYFENYVDAGAlyafl 273
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSA----- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 274 drlglvametdgsagyavlNAFGLVVnssdkayeVGFGVFNMLGALvqffgvilLSGFLANRYGKKRVFIVCLSLTAIFT 353
Cdd:COG2814 243 -------------------SAAGLLL--------ALFGLGGVLGAL--------LAGRLADRFGRRRLLLIGLLLLALGL 287
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1467206168 354 ALFYFPGkaDVETMFVLNFLKSLAYAPTVPLLWAMIADVA 393
Cdd:COG2814 288 LLLALAG--SLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
145-411 |
8.89e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.32 E-value: 8.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 145 KERTSITSIRFVAATIAQFVVQGLTLPLVSKFsdggdkahGWLCTISLFACIGFVFLVITFFSTRERIEPPASQKTDTRQ 224
Cdd:COG2223 125 DRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF--------GWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 225 DIKDVFGS-VPWRAMFILTLFIFITLAMWGSAMNYYFENYvdagalyafldrlglvametdgsaGYAVLNAFGLVvnssd 303
Cdd:COG2223 197 DQLEALRDpRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQF------------------------GLSAATAGLLA----- 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1467206168 304 kayevgfGVFNMLGALVQFFGvillsGFLANRYGKKRVFIVCLSLTAIFTALFYFPGkADVETMFVLNFLKSLAYAPTVP 383
Cdd:COG2223 248 -------ALFALLGALGRPLG-----GWLSDRIGGRRVLLIVFALMALGLLLLALAL-GSLWLFLVLFLLLGLALGGGNG 314
|
250 260
....*....|....*....|....*...
gi 1467206168 384 LLWAMiadVADYSEYKNYRRATGFVFAG 411
Cdd:COG2223 315 AVFAL---VPDIFPTKNAGAVYGLVGAA 339
|
|
| |
