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Conserved domains on  [gi|1476709924|gb|RIE70969|]
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hypothetical protein CUA61_00480 [Shigella flexneri]

Protein Classification

Barstar domain-containing protein( domain architecture ID 10142313)

Barstar domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Barstar cd05142
Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus ...
 3-88 3.34e-27

Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell. Barstar also binds and inhibits a ribonuclease called RNase Sa (produced by Streptomyces aureofaciens) which belongs to the same enzyme family as does barnase.


:

Pssm-ID: 240165  Cd Length: 87  Bit Score: 94.70  E-value: 3.34e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476709924  3 IYTFDFDEIESQEDFYRDFSQTFGLAKDKVRDLDSLWDVLMNDVLpLPLEIEFVHLGEKTRR-RFGALILLFDEAEEELE 81
Cdd:cd05142    1 KVVIDGEEIRSIEDLHQILKKELALPEYYGENLDALWDCLTGWVE-LPLTIEWKNFEQSKQRlGNYAESLLQVFAEAEEE 79


                 ....*...
gi 1476709924 82 -GHLRFNV 88
Cdd:cd05142   80 gGDLKFNV 87
 
Name Accession Description Interval E-value
Barstar cd05142
Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus ...
 3-88 3.34e-27

Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell. Barstar also binds and inhibits a ribonuclease called RNase Sa (produced by Streptomyces aureofaciens) which belongs to the same enzyme family as does barnase.


Pssm-ID: 240165  Cd Length: 87  Bit Score: 94.70  E-value: 3.34e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476709924  3 IYTFDFDEIESQEDFYRDFSQTFGLAKDKVRDLDSLWDVLMNDVLpLPLEIEFVHLGEKTRR-RFGALILLFDEAEEELE 81
Cdd:cd05142    1 KVVIDGEEIRSIEDLHQILKKELALPEYYGENLDALWDCLTGWVE-LPLTIEWKNFEQSKQRlGNYAESLLQVFAEAEEE 79


                 ....*...
gi 1476709924 82 -GHLRFNV 88
Cdd:cd05142   80 gGDLKFNV 87
BarS COG2732
Barstar, RNAse (barnase) inhibitor [Transcription];
3-90 2.46e-26

Barstar, RNAse (barnase) inhibitor [Transcription];


Pssm-ID: 442038  Cd Length: 90  Bit Score: 92.29  E-value: 2.46e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476709924  3 IYTFDFDEIESQEDFYRDFSQTFGLAKDKVRDLDSLWDVLMnDVLPLPLEIEFVHLGEKTRRR---FGALILLFDEAEEE 79
Cdd:COG2732    1 TVVIDGSEIRDEEDFYRQLARALDFPDYFGRNLDALWDCLT-GGVELPVELVWKNAEASRRRLgedFEALIEVLEEAEEE 79

                         90
                 ....*....|.
gi 1476709924 80 LEGHLRFNVRH 90
Cdd:COG2732   80 LEGDLRFNLRD 90
 
Name Accession Description Interval E-value
Barstar cd05142
Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus ...
 3-88 3.34e-27

Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell. Barstar also binds and inhibits a ribonuclease called RNase Sa (produced by Streptomyces aureofaciens) which belongs to the same enzyme family as does barnase.


Pssm-ID: 240165  Cd Length: 87  Bit Score: 94.70  E-value: 3.34e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476709924  3 IYTFDFDEIESQEDFYRDFSQTFGLAKDKVRDLDSLWDVLMNDVLpLPLEIEFVHLGEKTRR-RFGALILLFDEAEEELE 81
Cdd:cd05142    1 KVVIDGEEIRSIEDLHQILKKELALPEYYGENLDALWDCLTGWVE-LPLTIEWKNFEQSKQRlGNYAESLLQVFAEAEEE 79


                 ....*...
gi 1476709924 82 -GHLRFNV 88
Cdd:cd05142   80 gGDLKFNV 87
BarS COG2732
Barstar, RNAse (barnase) inhibitor [Transcription];
3-90 2.46e-26

Barstar, RNAse (barnase) inhibitor [Transcription];


Pssm-ID: 442038  Cd Length: 90  Bit Score: 92.29  E-value: 2.46e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476709924  3 IYTFDFDEIESQEDFYRDFSQTFGLAKDKVRDLDSLWDVLMnDVLPLPLEIEFVHLGEKTRRR---FGALILLFDEAEEE 79
Cdd:COG2732    1 TVVIDGSEIRDEEDFYRQLARALDFPDYFGRNLDALWDCLT-GGVELPVELVWKNAEASRRRLgedFEALIEVLEEAEEE 79

                         90
                 ....*....|.
gi 1476709924 80 LEGHLRFNVRH 90
Cdd:COG2732   80 LEGDLRFNLRD 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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