NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1481644539|gb|RJI92287|]
View 

baseplate protein [Salmonella enterica subsp. enterica serovar Lubbock]

Protein Classification

GPW/gp25 family protein( domain architecture ID 10007624)

GPW/gp25 family protein similar to type VI secretion system (T6SS) baseplate subunit TssE, which is a component of the T6SS baseplate that serves not only as the tail assembly platform, but also docks the tail to the membrane complex

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG3628 COG3628
Phage baseplate assembly protein W [Mobilome: prophages, transposons];
21-105 1.35e-26

Phage baseplate assembly protein W [Mobilome: prophages, transposons];


:

Pssm-ID: 442846  Cd Length: 119  Bit Score: 95.32  E-value: 1.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481644539  21 EYVCGLDDIHQAIHIILRTPRGSDPHRPLFGSNLWRYIDYPIERA-IPHVVRESVEAIRMWEPRCRLLKVTPTIDGE--- 96
Cdd:COG3628    14 AMVSGEEHIRQSIRIILTTPPGERVMRPDFGSGLHDLLFEPNNPAtALLIRAAVAEALLRWEPRIEVESVDVTPDPEedg 93


                  ....*....
gi 1481644539  97 HLTLRVQWR 105
Cdd:COG3628    94 KLLITIDYT 102
 
Name Accession Description Interval E-value
COG3628 COG3628
Phage baseplate assembly protein W [Mobilome: prophages, transposons];
21-105 1.35e-26

Phage baseplate assembly protein W [Mobilome: prophages, transposons];


Pssm-ID: 442846  Cd Length: 119  Bit Score: 95.32  E-value: 1.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481644539  21 EYVCGLDDIHQAIHIILRTPRGSDPHRPLFGSNLWRYIDYPIERA-IPHVVRESVEAIRMWEPRCRLLKVTPTIDGE--- 96
Cdd:COG3628    14 AMVSGEEHIRQSIRIILTTPPGERVMRPDFGSGLHDLLFEPNNPAtALLIRAAVAEALLRWEPRIEVESVDVTPDPEedg 93


                  ....*....
gi 1481644539  97 HLTLRVQWR 105
Cdd:COG3628    94 KLLITIDYT 102
GPW_gp25 pfam04965
Baseplate wedge protein gp25; This family represents T4 phage gp25 protein and gp25-like ...
 25-103 4.49e-11

Baseplate wedge protein gp25; This family represents T4 phage gp25 protein and gp25-like proteins, found in several systems, including contractile tail bacteriophages, the type VI secretion system (T6SS) and R-type pyocins, which constitute a multiprotein tubular apparatus to attach to and penetrate host cell membranes. Gp25 is a component of the conserved wedge in the inner part of the baseplate and serves as a nucleus for sheath polymerization, playing a critical role in sheath assembly and contraction. The EPR motif (Glu-Pro-Arg, residues 85-87 of gp25) is conserved across all members of the family including orthologs from the RpoS-mediated general stress response system (called IraD). This motif interacts with the 'core bundle' composed of orthologs of T4 gp6 and gp7 proteins in contractile injection systems.


Pssm-ID: 428225  Cd Length: 93  Bit Score: 54.89  E-value: 4.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481644539  25 GLDDIHQAIHIILRTPRGSDPHRPLFGSNLWRYIDYPIERAIPHVVRESVE-AIRMWEPRCRLLKVTPTID-GEHLTLRV 102
Cdd:pfam04965   3 LRESVRRDLEILLNTRPGERVSRPNYGCPDLALLFAPNDDATRALIERAIReAILRFEPRIRVVSVEVDPDpDSPGTLRF 82


                  .
gi 1481644539 103 Q 103
Cdd:pfam04965  83 T 83
W PHA02516
baseplate wedge subunit; Provisional
 25-94 3.92e-08

baseplate wedge subunit; Provisional


Pssm-ID: 134016  Cd Length: 103  Bit Score: 47.39  E-value: 3.92e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1481644539  25 GLDDIHQAIHIILRTPRGSDPHRPLFGSNLWRYIDYPIERA-IPHVVRESVEAIRMWEPRCRLLKVTPTID 94
Cdd:PHA02516   11 DLEHIRQSIGDILLTPLGSRVMRREYGSLLPDLIDQPQNPAlRLQIYAACAMALMRWEPRITLTRVQIERA 81
 
Name Accession Description Interval E-value
COG3628 COG3628
Phage baseplate assembly protein W [Mobilome: prophages, transposons];
21-105 1.35e-26

Phage baseplate assembly protein W [Mobilome: prophages, transposons];


Pssm-ID: 442846  Cd Length: 119  Bit Score: 95.32  E-value: 1.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481644539  21 EYVCGLDDIHQAIHIILRTPRGSDPHRPLFGSNLWRYIDYPIERA-IPHVVRESVEAIRMWEPRCRLLKVTPTIDGE--- 96
Cdd:COG3628    14 AMVSGEEHIRQSIRIILTTPPGERVMRPDFGSGLHDLLFEPNNPAtALLIRAAVAEALLRWEPRIEVESVDVTPDPEedg 93


                  ....*....
gi 1481644539  97 HLTLRVQWR 105
Cdd:COG3628    94 KLLITIDYT 102
GPW_gp25 pfam04965
Baseplate wedge protein gp25; This family represents T4 phage gp25 protein and gp25-like ...
 25-103 4.49e-11

Baseplate wedge protein gp25; This family represents T4 phage gp25 protein and gp25-like proteins, found in several systems, including contractile tail bacteriophages, the type VI secretion system (T6SS) and R-type pyocins, which constitute a multiprotein tubular apparatus to attach to and penetrate host cell membranes. Gp25 is a component of the conserved wedge in the inner part of the baseplate and serves as a nucleus for sheath polymerization, playing a critical role in sheath assembly and contraction. The EPR motif (Glu-Pro-Arg, residues 85-87 of gp25) is conserved across all members of the family including orthologs from the RpoS-mediated general stress response system (called IraD). This motif interacts with the 'core bundle' composed of orthologs of T4 gp6 and gp7 proteins in contractile injection systems.


Pssm-ID: 428225  Cd Length: 93  Bit Score: 54.89  E-value: 4.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1481644539  25 GLDDIHQAIHIILRTPRGSDPHRPLFGSNLWRYIDYPIERAIPHVVRESVE-AIRMWEPRCRLLKVTPTID-GEHLTLRV 102
Cdd:pfam04965   3 LRESVRRDLEILLNTRPGERVSRPNYGCPDLALLFAPNDDATRALIERAIReAILRFEPRIRVVSVEVDPDpDSPGTLRF 82


                  .
gi 1481644539 103 Q 103
Cdd:pfam04965  83 T 83
W PHA02516
baseplate wedge subunit; Provisional
 25-94 3.92e-08

baseplate wedge subunit; Provisional


Pssm-ID: 134016  Cd Length: 103  Bit Score: 47.39  E-value: 3.92e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1481644539  25 GLDDIHQAIHIILRTPRGSDPHRPLFGSNLWRYIDYPIERA-IPHVVRESVEAIRMWEPRCRLLKVTPTID 94
Cdd:PHA02516   11 DLEHIRQSIGDILLTPLGSRVMRREYGSLLPDLIDQPQNPAlRLQIYAACAMALMRWEPRITLTRVQIERA 81
25 PHA00415
baseplate wedge subunit
 25-94 2.14e-07

baseplate wedge subunit


Pssm-ID: 222788  Cd Length: 131  Bit Score: 46.15  E-value: 2.14e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1481644539  25 GLDDIHQAIHIILRTPRGSDPHRPLFGSNLWRYIDYPIERAIPHVVRESVE-AIRMWEPRCRLLK--VTPTID 94
Cdd:PHA00415   29 GARAIKNSLLGIVTTRKGERPFDPNFGCDISDQLFENMDPLTADTIERNIEsAIRNYEPRVYNLNveVIPVYD 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH