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Conserved domains on  [gi|1490383385|gb|RLA29698|]
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methyltransferase [Gammaproteobacteria bacterium]

Protein Classification

trimethylamine methyltransferase family protein( domain architecture ID 10533356)

trimethylamine methyltransferase family protein similar to Desulfitobacterium hafniense glycine betaine methyltransferase that likely methylates a corrinoid protein, likely the adjacently encoded DSY3155, with glycine betaine, to then supply methyl groups to tetrahydrofolate for ultimate conversion to carbon dioxide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 16-501 0e+00

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


:

Pssm-ID: 428852  Cd Length: 502  Bit Score: 617.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385  16 VQLPWRNVINPYAPVEVLDESQIETIIQAALKVLETQGMRFLEPGSRKIMQRAGAEVDepGKMVRIDHVLVEEKLALAPP 95
Cdd:pfam06253  17 ADQSWPYIVRGIPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDPEALELWRAAGADVD--GERVRFDRGLVRELLATAPR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385  96 RFGLRARNPAHNLKVGDNNILFSSVGGPAFCSDLDNGRRPGTYDEMCDYLRLIQSLNIVHQEGGGPFEALDLPAETRHLD 175
Cdd:pfam06253  95 QFTLHARNPERDVVIGGNNLVFAPVYGPPFVRDLDRGRRYGTLADFRNFVKLTQMFPWLHHSGGTVVEPVDVPVNKRHLD 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 176 LYLAQIRLLDKNAQSYALGGARTADSIEMTCIALGTDRAGLAEVPALLGVINTNSPMQLDIPMTEAVMELAGAGQVCCIT 255
Cdd:pfam06253 175 MLYAHLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSFAEFRANPVMTTNINVNSPLTFDETMLGGLRVYARAGQAVIVT 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 256 PFTLAGSMSPATLAGTLVQQTAEVLGVATFAQVVRPGAPIMYGSFASNVDMRSGAPALGTPEYAKAAQASGQIARRLGLP 335
Cdd:pfam06253 255 PFILAGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPALATYVAGQLARRYGLP 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 336 FRSSNT-TVSNCVDGQAVFESEMSLWGSIMGHANLVNHAAGWLEGGLTASFEKLIIDAEMLQMMAEYLRPIEVSEDELAL 414
Cdd:pfam06253 335 WRSSGGlTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMIHRLLAGIDVSDDALAM 414

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 415 DAIAEVGPGGHHFGTSHTLERYESAFYTPILSNRQNFESWQESGSIDISARANTIWKQLLREYEQPPLDPAIDEALVEYV 494
Cdd:pfam06253 415 DAIREVGPGGHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKILAEYEAPPLDPAIDEALRDFI 494


                  ....*..
gi 1490383385 495 SKRKQAI 501
Cdd:pfam06253 495 ARRKAEG 501
 
Name Accession Description Interval E-value
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 16-501 0e+00

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


Pssm-ID: 428852  Cd Length: 502  Bit Score: 617.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385  16 VQLPWRNVINPYAPVEVLDESQIETIIQAALKVLETQGMRFLEPGSRKIMQRAGAEVDepGKMVRIDHVLVEEKLALAPP 95
Cdd:pfam06253  17 ADQSWPYIVRGIPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDPEALELWRAAGADVD--GERVRFDRGLVRELLATAPR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385  96 RFGLRARNPAHNLKVGDNNILFSSVGGPAFCSDLDNGRRPGTYDEMCDYLRLIQSLNIVHQEGGGPFEALDLPAETRHLD 175
Cdd:pfam06253  95 QFTLHARNPERDVVIGGNNLVFAPVYGPPFVRDLDRGRRYGTLADFRNFVKLTQMFPWLHHSGGTVVEPVDVPVNKRHLD 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 176 LYLAQIRLLDKNAQSYALGGARTADSIEMTCIALGTDRAGLAEVPALLGVINTNSPMQLDIPMTEAVMELAGAGQVCCIT 255
Cdd:pfam06253 175 MLYAHLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSFAEFRANPVMTTNINVNSPLTFDETMLGGLRVYARAGQAVIVT 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 256 PFTLAGSMSPATLAGTLVQQTAEVLGVATFAQVVRPGAPIMYGSFASNVDMRSGAPALGTPEYAKAAQASGQIARRLGLP 335
Cdd:pfam06253 255 PFILAGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPALATYVAGQLARRYGLP 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 336 FRSSNT-TVSNCVDGQAVFESEMSLWGSIMGHANLVNHAAGWLEGGLTASFEKLIIDAEMLQMMAEYLRPIEVSEDELAL 414
Cdd:pfam06253 335 WRSSGGlTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMIHRLLAGIDVSDDALAM 414

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 415 DAIAEVGPGGHHFGTSHTLERYESAFYTPILSNRQNFESWQESGSIDISARANTIWKQLLREYEQPPLDPAIDEALVEYV 494
Cdd:pfam06253 415 DAIREVGPGGHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKILAEYEAPPLDPAIDEALRDFI 494


                  ....*..
gi 1490383385 495 SKRKQAI 501
Cdd:pfam06253 495 ARRKAEG 501
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
29-497 0e+00

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


Pssm-ID: 444334  Cd Length: 469  Bit Score: 604.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385  29 PVEVLDESQIETIIQAALKVLETQGMRFLEPGSRKIMQRAGAEVDepGKMVRIDHVLVEEKLALAPPRFGLRARNPAHNL 108
Cdd:COG5598     2 RYEPLSEEQIERIHEAALRILEEIGVEFEHEEALEIFKKAGARVE--GGRVRIPRALVEEALATAPSSFTLYARNPERDV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 109 KVGDNNILFSSVGGPAFCSDLDNG-RRPGTYDEMCDYLRLIQSLNIVHQEGGGPFEALDLPAETRHLDLYLAQIRLLDKN 187
Cdd:COG5598    80 ELGGGNVVFGPGGGAPFVLDLETGeRRPATLEDLANFAKLADALPNIDFSGGNPVEPSDVPVEVRHLDMLYAMLKYTDKP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 188 AQSYALGGARTADSIEMTCIALGTDRAgLAEVPALLGVINTNSPMQLDIPMTEAVMELAGAGQVCCITPFTLAGSMSPAT 267
Cdd:COG5598   160 IMGSATGRERVEDSIEMARIVAGGEEE-LREKPVVITLINPNSPLRFDEEMLEALIAYARAGQPVIITPFGLAGATAPVT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 268 LAGTLVQQTAEVLGVATFAQVVRPGAPIMYGSFASNVDMRSGAPALGTPEYAKAAQASGQIARRLGLPFRSSNT-TVSNC 346
Cdd:COG5598   239 LAGALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRSGGGlTDSKL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 347 VDGQAVFESEMSLWGSIMGHANLVNHAAGWLEGGLTASFEKLIIDAEMLQMMAEYLRPIEVSEDELALDAIAEVGPGGHH 426
Cdd:COG5598   319 PDAQAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRGIEVDEETLALDAIKEVGPGGHF 398

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490383385 427 FGTSHTLERYESAFYTPILSNRQNFESWQESGSIDISARANTIWKQLLREYEQPPLDPAIDEALVEYVSKR 497
Cdd:COG5598   399 LGHPHTLKHYRTEFYYPKLSDRENYEQWEEAGSKDLLERANEKVKEILAEYEPPPLDPEIDEELDAYIARR 469
 
Name Accession Description Interval E-value
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 16-501 0e+00

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


Pssm-ID: 428852  Cd Length: 502  Bit Score: 617.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385  16 VQLPWRNVINPYAPVEVLDESQIETIIQAALKVLETQGMRFLEPGSRKIMQRAGAEVDepGKMVRIDHVLVEEKLALAPP 95
Cdd:pfam06253  17 ADQSWPYIVRGIPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDPEALELWRAAGADVD--GERVRFDRGLVRELLATAPR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385  96 RFGLRARNPAHNLKVGDNNILFSSVGGPAFCSDLDNGRRPGTYDEMCDYLRLIQSLNIVHQEGGGPFEALDLPAETRHLD 175
Cdd:pfam06253  95 QFTLHARNPERDVVIGGNNLVFAPVYGPPFVRDLDRGRRYGTLADFRNFVKLTQMFPWLHHSGGTVVEPVDVPVNKRHLD 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 176 LYLAQIRLLDKNAQSYALGGARTADSIEMTCIALGTDRAGLAEVPALLGVINTNSPMQLDIPMTEAVMELAGAGQVCCIT 255
Cdd:pfam06253 175 MLYAHLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSFAEFRANPVMTTNINVNSPLTFDETMLGGLRVYARAGQAVIVT 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 256 PFTLAGSMSPATLAGTLVQQTAEVLGVATFAQVVRPGAPIMYGSFASNVDMRSGAPALGTPEYAKAAQASGQIARRLGLP 335
Cdd:pfam06253 255 PFILAGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPALATYVAGQLARRYGLP 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 336 FRSSNT-TVSNCVDGQAVFESEMSLWGSIMGHANLVNHAAGWLEGGLTASFEKLIIDAEMLQMMAEYLRPIEVSEDELAL 414
Cdd:pfam06253 335 WRSSGGlTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMIHRLLAGIDVSDDALAM 414

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 415 DAIAEVGPGGHHFGTSHTLERYESAFYTPILSNRQNFESWQESGSIDISARANTIWKQLLREYEQPPLDPAIDEALVEYV 494
Cdd:pfam06253 415 DAIREVGPGGHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKILAEYEAPPLDPAIDEALRDFI 494


                  ....*..
gi 1490383385 495 SKRKQAI 501
Cdd:pfam06253 495 ARRKAEG 501
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
29-497 0e+00

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


Pssm-ID: 444334  Cd Length: 469  Bit Score: 604.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385  29 PVEVLDESQIETIIQAALKVLETQGMRFLEPGSRKIMQRAGAEVDepGKMVRIDHVLVEEKLALAPPRFGLRARNPAHNL 108
Cdd:COG5598     2 RYEPLSEEQIERIHEAALRILEEIGVEFEHEEALEIFKKAGARVE--GGRVRIPRALVEEALATAPSSFTLYARNPERDV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 109 KVGDNNILFSSVGGPAFCSDLDNG-RRPGTYDEMCDYLRLIQSLNIVHQEGGGPFEALDLPAETRHLDLYLAQIRLLDKN 187
Cdd:COG5598    80 ELGGGNVVFGPGGGAPFVLDLETGeRRPATLEDLANFAKLADALPNIDFSGGNPVEPSDVPVEVRHLDMLYAMLKYTDKP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 188 AQSYALGGARTADSIEMTCIALGTDRAgLAEVPALLGVINTNSPMQLDIPMTEAVMELAGAGQVCCITPFTLAGSMSPAT 267
Cdd:COG5598   160 IMGSATGRERVEDSIEMARIVAGGEEE-LREKPVVITLINPNSPLRFDEEMLEALIAYARAGQPVIITPFGLAGATAPVT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 268 LAGTLVQQTAEVLGVATFAQVVRPGAPIMYGSFASNVDMRSGAPALGTPEYAKAAQASGQIARRLGLPFRSSNT-TVSNC 346
Cdd:COG5598   239 LAGALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRSGGGlTDSKL 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1490383385 347 VDGQAVFESEMSLWGSIMGHANLVNHAAGWLEGGLTASFEKLIIDAEMLQMMAEYLRPIEVSEDELALDAIAEVGPGGHH 426
Cdd:COG5598   319 PDAQAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRGIEVDEETLALDAIKEVGPGGHF 398

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1490383385 427 FGTSHTLERYESAFYTPILSNRQNFESWQESGSIDISARANTIWKQLLREYEQPPLDPAIDEALVEYVSKR 497
Cdd:COG5598   399 LGHPHTLKHYRTEFYYPKLSDRENYEQWEEAGSKDLLERANEKVKEILAEYEPPPLDPEIDEELDAYIARR 469
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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