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Conserved domains on  [gi|1499585326|gb|RMS28899|]
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Permease of the major facilitator superfamily [Pseudomonas savastanoi]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 20-156 5.95e-58

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17368:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 407  Bit Score: 187.97  E-value: 5.95e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  20 VTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALATFGVGFFMRPVGGIVLGIYSDKRGRKAALSLTILLM 99
Cdd:cd17368     1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1499585326 100 ALGTLIIGLTPSFAQIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSL 156
Cdd:cd17368    81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGF 137
 
Name Accession Description Interval E-value
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 20-156 5.95e-58

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 187.97  E-value: 5.95e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  20 VTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALATFGVGFFMRPVGGIVLGIYSDKRGRKAALSLTILLM 99
Cdd:cd17368     1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1499585326 100 ALGTLIIGLTPSFAQIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSL 156
Cdd:cd17368    81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGF 137
PRK15075 PRK15075
tricarballylate/proton symporter TcuC;
1-154 5.94e-51

tricarballylate/proton symporter TcuC;


Pssm-ID: 237902 [Multi-domain]  Cd Length: 434  Bit Score: 170.51  E-value: 5.94e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326   1 MSTLRSSASRTHEQKARRAVTAtviGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALATFGVGFFMRPVGGIVLG 80
Cdd:PRK15075    1 MSTMTPAASRESKARAILRVTS---GNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLG 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1499585326  81 IYSDKRGRKAALSLTILLMALGTLIIGLTPSFAQIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKK 154
Cdd:PRK15075   78 AYIDRVGRRKGLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRK 151
2A0106 TIGR00883
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ...
 26-157 3.15e-49

metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273320 [Multi-domain]  Cd Length: 394  Bit Score: 164.75  E-value: 3.15e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  26 GNGLEWFDFTVYSFFSVIIAK-VFFPTGSELTSYLLALATFGVGFFMRPVGGIVLGIYSDKRGRKAALSLTILLMALGTL 104
Cdd:TIGR00883   1 GNAVEWFDFYLYGFAAVLVFHtFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1499585326 105 IIGLTPSFAQIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLL 157
Cdd:TIGR00883  81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFY 133
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 6-158 6.49e-20

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 85.25  E-value: 6.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326   6 SSASRTHEQKARRAVTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELtsyllaLATFGVGFFMRPVGGIVLGIYSDK 85
Cdd:COG0477     2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL------GWIVSAYLLGRAIGLLLFGRLGDR 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1499585326  86 RGRKAALSLTILLMALGTLIIGLTPSfaqigylaPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLLL 158
Cdd:COG0477    76 YGRKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRAL 140
Sugar_tr pfam00083
Sugar (and other) transporter;
19-160 1.82e-10

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 59.59  E-value: 1.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  19 AVTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALA---TFGVGFFM--RPVGGIVLGIYSDKRGRKAALS 93
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSLAALSvlsGLIVSIFSvgCFIGSLFAGKLGDRFGRKKSLL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1499585326  94 LTILLMALGTLIIGLTPsfaqiGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLLLQL 160
Cdd:pfam00083  81 IANVLFVIGAVLQGAAK-----GKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSL 142
 
Name Accession Description Interval E-value
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 20-156 5.95e-58

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 187.97  E-value: 5.95e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  20 VTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALATFGVGFFMRPVGGIVLGIYSDKRGRKAALSLTILLM 99
Cdd:cd17368     1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1499585326 100 ALGTLIIGLTPSFAQIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSL 156
Cdd:cd17368    81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGF 137
PRK15075 PRK15075
tricarballylate/proton symporter TcuC;
1-154 5.94e-51

tricarballylate/proton symporter TcuC;


Pssm-ID: 237902 [Multi-domain]  Cd Length: 434  Bit Score: 170.51  E-value: 5.94e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326   1 MSTLRSSASRTHEQKARRAVTAtviGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALATFGVGFFMRPVGGIVLG 80
Cdd:PRK15075    1 MSTMTPAASRESKARAILRVTS---GNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLG 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1499585326  81 IYSDKRGRKAALSLTILLMALGTLIIGLTPSFAQIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKK 154
Cdd:PRK15075   78 AYIDRVGRRKGLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRK 151
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
 20-157 1.86e-50

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 167.53  E-value: 1.86e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  20 VTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALATFGVGFFMRPVGGIVLGIYSDKRGRKAALSLTILLM 99
Cdd:cd17366     1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILM 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1499585326 100 ALGTLIIGLTPSFAQIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLL 157
Cdd:cd17366    81 AASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFL 138
2A0106 TIGR00883
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ...
 26-157 3.15e-49

metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273320 [Multi-domain]  Cd Length: 394  Bit Score: 164.75  E-value: 3.15e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  26 GNGLEWFDFTVYSFFSVIIAK-VFFPTGSELTSYLLALATFGVGFFMRPVGGIVLGIYSDKRGRKAALSLTILLMALGTL 104
Cdd:TIGR00883   1 GNAVEWFDFYLYGFAAVLVFHtFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1499585326 105 IIGLTPSFAQIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLL 157
Cdd:TIGR00883  81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFY 133
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 17-157 3.85e-49

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 165.01  E-value: 3.85e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  17 RRAVTATVIGNGLEWFDFTVYSFFSVII-AKVFFPTGSELTSYLLALATFGVGFFMRPVGGIVLGIYSDKRGRKAALSLT 95
Cdd:cd17369     1 RRVALASLVGTAIEWYDFFIYGTAAALVfNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1499585326  96 ILLMALGTLIIGLTPSFAQIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLL 157
Cdd:cd17369    81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFY 142
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 22-154 1.30e-48

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 163.62  E-value: 1.30e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  22 ATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALATFGVGFFMRPVGGIVLGIYSDKRGRKAALSLTILLMAL 101
Cdd:cd17367     3 GGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAA 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1499585326 102 GTLIIGLTPSFAQIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKK 154
Cdd:cd17367    83 GSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRR 135
PRK10642 PRK10642
proline/glycine betaine transporter ProP;
15-157 4.45e-43

proline/glycine betaine transporter ProP;


Pssm-ID: 182611 [Multi-domain]  Cd Length: 490  Bit Score: 150.63  E-value: 4.45e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  15 KARRAVTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALATFGVGFFMRPVGGIVLGIYSDKRGRKAALSL 94
Cdd:PRK10642   13 KLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAI 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1499585326  95 TILLMALGTLIIGLTPSFAQIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLL 157
Cdd:PRK10642   93 TIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFM 155
PRK10406 PRK10406
alpha-ketoglutarate transporter; Provisional
 2-154 3.46e-37

alpha-ketoglutarate transporter; Provisional


Pssm-ID: 182433 [Multi-domain]  Cd Length: 432  Bit Score: 134.17  E-value: 3.46e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326   2 STLRSSASRTHEQKARRAVTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALATFGVGFFMRPVGGIVLGI 81
Cdd:PRK10406    6 VTADSKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGR 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1499585326  82 YSDKRGRKAALSLTILLMALGTLIIGLTPSFAQIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKK 154
Cdd:PRK10406   86 IADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRK 158
PRK09952 PRK09952
shikimate transporter; Provisional
 1-155 3.91e-37

shikimate transporter; Provisional


Pssm-ID: 182163 [Multi-domain]  Cd Length: 438  Bit Score: 134.09  E-value: 3.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326   1 MSTLRSSASRTHEQKARRAVTATVIGNGLEWFDFTVYSFFSVII-AKVFFPTGSELTSYLLALATFGVGFFMRPVGGIVL 79
Cdd:PRK09952    5 LISTRPDEGTLSLSRARRAALGSFAGAVVDWYDFLLYGITAALVfNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVF 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1499585326  80 GIYSDKRGRKAALSLTILLMALGTLIIGLTPSFAQIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKS 155
Cdd:PRK09952   85 GHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKA 160
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 20-158 6.78e-28

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 107.69  E-value: 6.78e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  20 VTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLalatFGVGFFMRPVGGIVLGIYSDKRGRKAALSLTILLM 99
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLL----FAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1499585326 100 ALGTLIIGLTPSfaqigylaPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLLL 158
Cdd:cd17316    77 GLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFAL 127
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 6-158 6.49e-20

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 85.25  E-value: 6.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326   6 SSASRTHEQKARRAVTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELtsyllaLATFGVGFFMRPVGGIVLGIYSDK 85
Cdd:COG0477     2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL------GWIVSAYLLGRAIGLLLFGRLGDR 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1499585326  86 RGRKAALSLTILLMALGTLIIGLTPSfaqigylaPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLLL 158
Cdd:COG0477    76 YGRKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRAL 140
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
15-160 7.65e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 66.44  E-value: 7.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  15 KARRAVTATVIGNGLEWFDFTVYSFFSVIIAKVFfptgsELTSYLLALAtFGVGFFMRPVGGIVLGIYSDKRGRKAALSL 94
Cdd:COG2223     2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF-----GLSAAQLGLL-FAIPVLVGALLRIPLGFLVDRFGPRRVLLI 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1499585326  95 TILLMALGTLIIGLTPSFAQigylapllIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLLLQL 160
Cdd:COG2223    76 GLLLLGIGLLLLALAVSYWL--------LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGL 133
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
11-158 1.47e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 62.68  E-value: 1.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  11 THEQKARRAVTATVIGNGLEWFDFTVYSFFSVIIAKVFFptgselTSYLLALATFGVGFFMRPVGGIVLGIYSDKRGRKA 90
Cdd:COG2814     3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLG------ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRR 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1499585326  91 ALSLTILLMALGTLIIGLTPSFAqigylaplLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLLL 158
Cdd:COG2814    77 VLLLGLLLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRAL 136
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
9-158 1.81e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 62.19  E-value: 1.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326   9 SRTHEQKARRAVTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTsylLALATFGVGFFmrpVGGIVLGIYSDKRGR 88
Cdd:COG2271     1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLG---LLASAFFLGYA---LGQIPAGLLADRFGR 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  89 KAALSLTILLMALGTLIIGLTPSFAQigylapllIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLLL 158
Cdd:COG2271    75 RRVLAIGLLLWGLATLLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRAL 136
Sugar_tr pfam00083
Sugar (and other) transporter;
19-160 1.82e-10

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 59.59  E-value: 1.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  19 AVTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALA---TFGVGFFM--RPVGGIVLGIYSDKRGRKAALS 93
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSLAALSvlsGLIVSIFSvgCFIGSLFAGKLGDRFGRKKSLL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1499585326  94 LTILLMALGTLIIGLTPsfaqiGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLLLQL 160
Cdd:pfam00083  81 IANVLFVIGAVLQGAAK-----GKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSL 142
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 17-150 1.16e-09

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 57.40  E-value: 1.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  17 RRAVTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLAlatfgvGFFMRPVGGIVLGIYSDKRGRKAALSLTI 96
Cdd:PRK03893   19 WKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISA------AFISRWFGGLLLGAMGDRYGRRLAMVISI 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1499585326  97 LLMALGTLIIGLTPSFAqigylaplLIVLARLLQGFSAGGEMGSATAFLTEHAP 150
Cdd:PRK03893   93 VLFSVGTLACGFAPGYW--------TLFIARLVIGMGMAGEYGSSATYVIESWP 138
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 18-160 3.99e-08

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 52.36  E-value: 3.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  18 RAVTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELtSYLLALATFGVGFfmrpvGGIVLGIYSDKRGRKAALSLTIL 97
Cdd:TIGR00895  17 RAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQL-GFLFSAGLIGMAF-----GALFFGPLADRIGRRRVLLWSIL 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1499585326  98 LMALGTLIIGLTPSFAQIGYLapllivlaRLLQGFSAGGEMGSATAFLTEHAPEGKKSLLLQL 160
Cdd:TIGR00895  91 LFSVFTLLCALATNVTQLLIL--------RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGL 145
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 29-157 1.07e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 51.05  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  29 LEWFDFTVYSFFSVIIAKVFFPTGSELTSyLLALATFGVGffmrpVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGL 108
Cdd:cd17365    10 LDGFDLAVMGFVAPALAQDWGLSPAQLGP-VGSAALFGMA-----IGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1499585326 109 TPSFAQIGylapllivLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLL 157
Cdd:cd17365    84 AQSVLQLA--------LLRFLTGLGLGAAMPNAITLVSEYAPARRRSLA 124
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 22-154 5.09e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 49.22  E-value: 5.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  22 ATVIGNGLEWFDFTVYSFFSVIIAKVFfptgsELTSYLLALATFGVGFFMrPVGGIVLGIYSDKRGRKAALSLTILLMAL 101
Cdd:cd17371     3 AAFLGWALDGFDLLLLGLVLPALIAEF-----GLDEAEAGLLGTVTLAGG-AIGGILGGILADRFGRVRVLVITILLFAV 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1499585326 102 GTLIIGLTPSFAQigylapllIVLARLLQGFSAGGEMGSATAFLTEHAPEGKK 154
Cdd:cd17371    77 FTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHR 121
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 57-154 1.70e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.54  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  57 SYLLALATFGVGffmrpVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFAqigylaplLIVLARLLQGFSAGG 136
Cdd:cd17324    37 GLLVSAYALGYA-----LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGG 103

                          90
                  ....*....|....*...
gi 1499585326 137 EMGSATAFLTEHAPEGKK 154
Cdd:cd17324   104 FWAIAAAYAADLVPPEKR 121
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-151 1.13e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.96  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326   5 RSSASRTHEQKARRAVTATVIGNGLEWFDFTVYSFFSVIIAKVFFptGSELTSYLLALATFGVGFFmrpVGGIVLGIYSD 84
Cdd:COG2814   194 ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL--GLSASAAGLLLALFGLGGV---LGALLAGRLAD 268

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1499585326  85 KRGRKAALSLTILLMALGTLIIGLTPSFAqigylaplLIVLARLLQGFSAGGEMGSATAFLTEHAPE 151
Cdd:COG2814   269 RFGRRRLLLIGLLLLALGLLLLALAGSLW--------LLLLALFLLGFGFGLLFPLLQALVAELAPP 327
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 65-154 2.76e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.10  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  65 FGVGFFMRPVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFAQigylapllIVLARLLQGFSAGGEMGSATAF 144
Cdd:cd17325    37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--------LLLARFLQGLASAAVWPAAMAL 108

                          90
                  ....*....|
gi 1499585326 145 LTEHAPEGKK 154
Cdd:cd17325   109 IADIAPPEER 118
MFS_1 pfam07690
Major Facilitator Superfamily;
23-158 2.84e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 2.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  23 TVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALATFGVGFFMrpvggIVLGIYSDKRGRKAALSLTILLMALG 102
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQ-----PLAGRLSDRFGRRRVLLIGLLLFALG 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1499585326 103 TLIIGLTPSFaqigylapLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLLL 158
Cdd:pfam07690  76 LLLLLFASSL--------WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRAL 123
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 15-151 3.20e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 43.76  E-value: 3.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  15 KARRAVTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALatFGVGFFmrpVGGIVLGIYSDKRGRKAALSL 94
Cdd:cd06173   205 RRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAA--FGVGAL---LGALLLGRLSKRRRRGRLLLI 279

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1499585326  95 TILLMALGTLIIGLTPSFAqigylaplLIVLARLLQGFSAGGEMGSATAFLTEHAPE 151
Cdd:cd06173   280 GALLLGLALLVLGLSPSLW--------LLLAALFLLGLAGGLFNVPLNTLLQLRVPD 328
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 74-160 1.37e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 41.95  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  74 VGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFAqigylaplLIVLARLLQGFSAGGEMGSATAFLTEHAPEGK 153
Cdd:cd17362    54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125


                  ....*..
gi 1499585326 154 KSLLLQL 160
Cdd:cd17362   126 RGLLVSL 132
PRK12307 PRK12307
MFS transporter;
17-155 1.65e-04

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 41.84  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  17 RRAVTATVIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTsyllALATfgVGFFMRPVGGIVLGIYSDKRGRKAALSLTI 96
Cdd:PRK12307   17 KNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGA----FLAT--AAFIGRPFGGALFGLLADKFGRKPLMMWSI 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1499585326  97 LLMALGTLIIGLTPSFaqigylapLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKS 155
Cdd:PRK12307   91 VAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKS 141
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 60-147 2.02e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 41.41  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  60 LALATFGVGFFmrpVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFAqigylaplLIVLARLLQGFSAGGEMG 139
Cdd:cd17317    29 LVQTIFFLGVL---IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFT 97


                  ....*...
gi 1499585326 140 SATAFLTE 147
Cdd:cd17317    98 VGFVLGME 105
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 44-148 2.14e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.40  E-value: 2.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  44 IAKVFFPTGSELTSYLLALATFGVGFFmrpvgGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFaqigylapLLI 123
Cdd:cd17473    25 IAQHFVPNSELLVPLLLTLPALFIALF-----APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL--------YAL 91

                          90       100
                  ....*....|....*....|....*
gi 1499585326 124 VLARLLQGFSAGGEMGSATAFLTEH 148
Cdd:cd17473    92 LASRALLGIGVAGIMTLATALIGDY 116
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 29-151 2.18e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 41.41  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  29 LEWFDFTVysFFSVIIAKVFFPTGSELTSYLLAL--ATFGVGFFmrpVGGIVLGIYSDKRGRKAALSLTILLMALGTLII 106
Cdd:cd17330     7 LDALGFGI--VFPVLPFYVREFNKLGASGYYVGLlqSSYSLGQF---LASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1499585326 107 GLTPSFaqigylapLLIVLARLLQGFSAGGeMGSATAFLTEHAPE 151
Cdd:cd17330    82 GLSRNL--------WLLFLARFLDGLTGGN-VSVAQAYIADITDE 117
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
60-157 2.22e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.38  E-value: 2.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  60 LALATFGVGFFmrpVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFAqigylaplLIVLARLLQGFSAGGEMG 139
Cdd:COG0738    47 LLLFAFFLGYL---LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP--------LLLLALFLLGLGLGLLDV 115

                          90
                  ....*....|....*...
gi 1499585326 140 SATAFLTEHAPEGKKSLL 157
Cdd:COG0738   116 AANPYVAALGPETAASRL 133
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 24-151 2.44e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 41.26  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  24 VIGNGLEWFDFTVYSFFSVIIAKvFFPTGSELTSYLLALATFGVGFFMrpvggIVLGIYSDKRGRKAALSLTILLMALGT 103
Cdd:cd06174     2 LLGFFLTGLARGLISPLLPALLQ-SFGLSASQLGLLFALFSLGYALLQ-----PLAGLLADRFGRRPVLLLGLLLFALGA 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1499585326 104 LIIGLTPSFaqigylapLLIVLARLLQGFSAGGEMGSATAFLTEHAPE 151
Cdd:cd06174    76 LLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPE 115
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 34-153 3.55e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 40.61  E-value: 3.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  34 FTVYSFFSVIIAKVFFPTGSELTsylLALATFGVGFFmrpVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSfa 113
Cdd:cd17324   215 FALYTYLAPFLTDVPGFSSSAII---GLLLLFGVAGV---VGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPS-- 286

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1499585326 114 qigylaPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEGK 153
Cdd:cd17324   287 ------PLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 55-145 4.01e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 40.64  E-value: 4.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  55 LTSYLLALAtfgvgffmrpVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFAQigylapllIVLARLLQGFSA 134
Cdd:cd17320    40 LSAYLLGFA----------LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLGA 101

                          90
                  ....*....|.
gi 1499585326 135 GGEMGSATAFL 145
Cdd:cd17320   102 AAGSVVARAIV 112
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 60-147 5.66e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 40.38  E-value: 5.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  60 LALATFGVGFFmrpVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFaqigylaPLLIVLaRLLQGFSAGGEMG 139
Cdd:TIGR00898 131 LTQSCFFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY-------TVFLVF-RLLVGMGIGGIWV 199


                  ....*...
gi 1499585326 140 SATAFLTE 147
Cdd:TIGR00898 200 QAVVLNTE 207
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 63-138 5.92e-04

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 40.03  E-value: 5.92e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1499585326  63 ATFGVGFFmrpVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFaqigylapLLIVLARLLQG-FSAGGEM 138
Cdd:cd17379    40 SSLNLGFL---IGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGlFGKGGWM 105
MFS_1 pfam07690
Major Facilitator Superfamily;
57-153 6.65e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 6.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  57 SYLLALATFGVGFFMRPVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFAQIGYLAPLLIVLarllqGFSAGG 136
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL-----GFGFGL 307

                          90
                  ....*....|....*..
gi 1499585326 137 EMGSATAFLTEHAPEGK 153
Cdd:pfam07690 308 VFPALNALVSDLAPKEE 324
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 62-150 8.06e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 39.55  E-value: 8.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  62 LATFGVGFFmrpVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGltpsFAQIGYLaPLLIVLARLLQGFSAGGEMGSA 141
Cdd:cd17357    55 VSIFFIGGA---IGSFISAFLANRFGRKNGLLISNALLVVSSLLMF----LSKSAKS-PELLIFGRFLVGIACGLSTGFV 126


                  ....*....
gi 1499585326 142 TAFLTEHAP 150
Cdd:cd17357   127 PMYLQEISP 135
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 34-150 8.88e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.51  E-value: 8.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  34 FTVYSFFSVIIAKVFFPTGSELTSYLLALATFGVgffmrpVGGIVLGIYSDKRGRKAALSLTILLMALGTLIigltpsFA 113
Cdd:cd17316   194 YGLTTFLPTYLQTVLGLSPATSSLYLLLISLGAL------VGALIAGLLSDRIGRKKTLVIGLILSGILALP------LF 261

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1499585326 114 QIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAP 150
Cdd:cd17316   262 YLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFP 298
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 55-153 9.25e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.46  E-value: 9.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  55 LTSYLLALATFGVgffmrpvggiVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFAQIgylaplliVLARLLQGFSA 134
Cdd:cd17321    37 VNAYLLAFAALLL----------LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL--------IAARALQGIGA 98

                          90
                  ....*....|....*....
gi 1499585326 135 GGEMGSATAFLTEHAPEGK 153
Cdd:cd17321    99 AAIMPASLALIAATFPGER 117
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 59-141 9.91e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.46  E-value: 9.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  59 LLALATFGVGFFMRPVggivLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFAQIGYLA-----------PLLIVLAR 127
Cdd:cd17478    35 LLVSVFSITSSLLQPL----FGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLValagigsaafhPEGARLAS 110

                          90       100
                  ....*....|....*....|...
gi 1499585326 128 LLQG---------FSAGGEMGSA 141
Cdd:cd17478   111 QAAGgrrglamsiFSVGGNLGFA 133
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
34-150 1.80e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 38.71  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  34 FTVYSFFSVIIAKVFFPTGSELTSYLLALATFgVGFFMRPVGGIVlgiySDKRGRKAALSLTILLMALGTLIIGLTPsfa 113
Cdd:COG2223   221 FIGFSSWLPPYLVDQFGLSAATAGLLAALFAL-LGALGRPLGGWL----SDRIGGRRVLLIVFALMALGLLLLALAL--- 292

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1499585326 114 qigyLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAP 150
Cdd:COG2223   293 ----GSLWLFLVLFLLLGLALGGGNGAVFALVPDIFP 325
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 73-147 1.91e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 38.43  E-value: 1.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1499585326  73 PVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFaqigylaPLLIVLaRLLQGFSAGGEMGSATAFLTE 147
Cdd:cd17374    49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTF-------PVYCVL-RFLAGFAVSGISINTLILGTE 115
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 32-137 2.19e-03

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 38.41  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  32 FDFTVYSFFSVIIAKVFFPTGSELTSYLLALATfGVGFFMRPVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPS 111
Cdd:cd17364    13 YDLFSISLVTKILGRLYYGGKGSLPSGVSGLVN-AAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPG 91

                          90       100
                  ....*....|....*....|....*.
gi 1499585326 112 FAQIGYLAPLLIVlaRLLQGFSAGGE 137
Cdd:cd17364    92 STPLGVMGWLIFF--RFLLGIGIGGD 115
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 74-150 2.72e-03

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 37.93  E-value: 2.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1499585326  74 VGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFAqigylaplLIVLARLLQGFSAGGEMGSATAFLTEHAP 150
Cdd:cd17359    51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFT--------IFIIARIIGGLAVGGASALVPMYIAEVAP 119
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 57-136 3.17e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 37.94  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  57 SYLLALATFGVGFFMrpvggIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFAqigylaplLIVLARLLQGFSAGG 136
Cdd:cd17474    37 GLLITAFTLPAAVLM-----PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRALQGIGAAG 103
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 34-158 4.95e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 37.17  E-value: 4.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  34 FTVYSFFSVIIAKVFF------PTGSELTSYLLALATFGVgffmrPVGGIVLGIYSDKRGRKAALSLTILLMALGTLIIG 107
Cdd:cd17473   207 FLAMLLFYVIPIQLPFllqergGGSAALIGLALAIASLAG-----AIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLA 281

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1499585326 108 LTPSFAqigylaplLIVLARLLQGFSAGGEMGSATAFLTEHAPEGKKSLLL 158
Cdd:cd17473   282 LASGLW--------VVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAM 324
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
24-152 5.58e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 37.19  E-value: 5.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  24 VIGNGLEWFDFTVYSFFSVIIAKVFFPTGSELTSYLLALATFGVGFFMrpvggIVLGIYSDKRGRKAALSLTILLMALGT 103
Cdd:COG2211   234 LLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGA-----PLWPRLAKRFGKKKAFIIGLLLAALGL 308

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1499585326 104 LIIGLtpsfaqIGYLAPLLIVLARLLQGFSAGGEMGSATAFLTEHAPEG 152
Cdd:COG2211   309 LLLFF------LGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYD 351
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 74-157 6.16e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 36.78  E-value: 6.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1499585326  74 VGGIVLGIYSDKRGRKAALSLTILLMALGTLIIGLTPSFAQigylapllIVLARLLQGFSAGGEMGSATAFLTEHAPEGK 153
Cdd:cd17315    49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120


                  ....
gi 1499585326 154 KSLL 157
Cdd:cd17315   121 RGAL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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