ABC transporter permease containing a MacB-like periplasmic core domain and a FtsX domain, similar to LolC/E, a heterodimer of transmembrane subunits, which is part of an ABC transporter complex (LolCDE) involved in lipoprotein release
lipoprotein releasing system, transmembrane protein, LolC/E family; This model describes the ...
4-414
8.56e-177
lipoprotein releasing system, transmembrane protein, LolC/E family; This model describes the LolC protein, and its paralog LolE found in some species. These proteins are homologous to permease proteins of ABC transporters. In some species, two paralogs occur, designated LolC and LolE. In others, a single form is found and tends to be designated LolC. [Protein fate, Protein and peptide secretion and trafficking]
:
Pssm-ID: 274034 [Multi-domain] Cd Length: 411 Bit Score: 499.11 E-value: 8.56e-177
lipoprotein releasing system, transmembrane protein, LolC/E family; This model describes the ...
4-414
8.56e-177
lipoprotein releasing system, transmembrane protein, LolC/E family; This model describes the LolC protein, and its paralog LolE found in some species. These proteins are homologous to permease proteins of ABC transporters. In some species, two paralogs occur, designated LolC and LolE. In others, a single form is found and tends to be designated LolC. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274034 [Multi-domain] Cd Length: 411 Bit Score: 499.11 E-value: 8.56e-177
FtsX-like permease family; This is a family of predicted permeases and hypothetical ...
273-407
9.00e-10
FtsX-like permease family; This is a family of predicted permeases and hypothetical transmembrane proteins. Swiss:P57382 has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both Swiss:P57382 and Swiss:O54500 have been shown to require ATP. This region contains three transmembrane helices.
Pssm-ID: 460652 [Multi-domain] Cd Length: 120 Bit Score: 56.10 E-value: 9.00e-10
lipoprotein releasing system, transmembrane protein, LolC/E family; This model describes the ...
4-414
8.56e-177
lipoprotein releasing system, transmembrane protein, LolC/E family; This model describes the LolC protein, and its paralog LolE found in some species. These proteins are homologous to permease proteins of ABC transporters. In some species, two paralogs occur, designated LolC and LolE. In others, a single form is found and tends to be designated LolC. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274034 [Multi-domain] Cd Length: 411 Bit Score: 499.11 E-value: 8.56e-177
lipoprotein releasing system, transmembrane protein LolE; This protein is part of an unusual ...
4-411
5.04e-105
lipoprotein releasing system, transmembrane protein LolE; This protein is part of an unusual ABC transporter complex that releases lipoproteins from the periplasmic side of the bacterial inner membrane, rather than transport any substrate across the inner membrane. In some species, the permease-like transmembrane protein is represented by two paralogs, LolC and LolE, both in the LolCDE complex. This family consists of LolE, as found in E. coli and related species. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 131268 [Multi-domain] Cd Length: 411 Bit Score: 316.78 E-value: 5.04e-105
Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease ...
28-412
7.28e-22
Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442361 [Multi-domain] Cd Length: 830 Bit Score: 97.95 E-value: 7.28e-22
Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease ...
27-414
7.18e-13
Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442361 [Multi-domain] Cd Length: 830 Bit Score: 70.60 E-value: 7.18e-13
FtsX-like permease family; This is a family of predicted permeases and hypothetical ...
273-407
9.00e-10
FtsX-like permease family; This is a family of predicted permeases and hypothetical transmembrane proteins. Swiss:P57382 has been shown to transport lipids targeted to the outer membrane across the inner membrane. Both Swiss:P57382 and Swiss:O54500 have been shown to require ATP. This region contains three transmembrane helices.
Pssm-ID: 460652 [Multi-domain] Cd Length: 120 Bit Score: 56.10 E-value: 9.00e-10
MacB-like periplasmic core domain; This family represents the periplasmic core domain found in ...
27-243
1.10e-07
MacB-like periplasmic core domain; This family represents the periplasmic core domain found in a variety of ABC transporters. The structure of this family has been solved for the MacB protein. Some structural similarity was found to the periplasmic domain of the AcrB multidrug efflux transporter.
Pssm-ID: 463676 [Multi-domain] Cd Length: 211 Bit Score: 52.15 E-value: 1.10e-07
Acidobacterial duplicated orphan permease; Members of this protein family are found, so far, ...
270-414
1.40e-06
Acidobacterial duplicated orphan permease; Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.
Pssm-ID: 274576 [Multi-domain] Cd Length: 803 Bit Score: 50.59 E-value: 1.40e-06
Acidobacterial duplicated orphan permease; Members of this protein family are found, so far, ...
274-412
6.53e-04
Acidobacterial duplicated orphan permease; Members of this protein family are found, so far, only in three species of Acidobacteria, namely Acidobacteria bacterium Ellin345, Acidobacterium capsulatum ATCC 51196, and Solibacter usitatus Ellin6076, where they form large paralogous families. Each protein contains two copies of a domain called the efflux ABC transporter permease protein (pfam02687). However, unlike other members of that family (including LolC, FtsX, and MacB), genes for these proteins are essentially never found fused or adjacent to ABC transporter ATP-binding protein (pfam00005) genes. We name this family ADOP, for Acidobacterial Duplicated Orphan Permease, to reflect the restricted lineage, internal duplication, lack of associated ATP-binding cassette proteins, and permease homology. The function is unknown.
Pssm-ID: 274576 [Multi-domain] Cd Length: 803 Bit Score: 42.11 E-value: 6.53e-04
putative protein insertion permease FtsX; FtsX is an integral membrane protein encoded in the ...
270-403
4.54e-03
putative protein insertion permease FtsX; FtsX is an integral membrane protein encoded in the same operon as signal recognition particle docking protein FtsY and FtsE. It belongs to a family of predicted permeases and may play a role in the insertion of proteins required for potassium transport, cell division, and other activities. FtsE is a hydrophilic nucleotide-binding protein that associates with the inner membrane by means of association with FtsX. [Cellular processes, Cell division, Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 182910 [Multi-domain] Cd Length: 309 Bit Score: 38.81 E-value: 4.54e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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