|
Name |
Accession |
Description |
Interval |
E-value |
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
14-354 |
0e+00 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 593.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 14 CDCFYAAIEMRDDPSLARRPIAVGGAADRRGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYREASREIHE 93
Cdd:PRK02406 1 MDCFYAAVEMRDNPELRGKPVAVGGSPGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 94 IFRTYTEQIEPLSLDEAYLDVSACEHFAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDGLFVVTPAQ 173
Cdd:PRK02406 81 IFRRYTDLIEPLSLDEAYLDVTDNKLCIGSATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 174 VEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFGAFGERLWGLAWGIDERPVQVESRRQSVSVEQT 253
Cdd:PRK02406 161 VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRRLYERARGIDERPVKPDRERKSVGVERT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 254 YDRDLPDLAACLERLPELLQQLSTRMARLDSGYRPGKPFVKLKFHDFTQTTLEQAGAGLELDDYADLLATAFSRRA--RP 331
Cdd:PRK02406 241 FAEDLYDLEACLAELPRLAEKLERRLERAKPDKRIKTVGVKLKFADFQQTTKEHTADPLDKADLIELLAQALLRRLggRG 320
|
330 340
....*....|....*....|...
gi 1533180264 332 VRLIGVGVRLIDLRGGFEQLRLF 354
Cdd:PRK02406 321 VRLLGVGVTLLEPQLERQLLLDL 343
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
10-342 |
1.14e-168 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 473.16 E-value: 1.14e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 10 IHIDCDCFYAAIEMRDDPSLARRPIAVGGAADRrGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYREASR 89
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSDR-GVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 90 EIHEIFRTYTEQIEPLSLDEAYLDVSACEHFAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDGLFVV 169
Cdd:cd03586 80 QIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 170 TPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFGAFGERLWGLAWGIDERPVQVESRRQSVS 249
Cdd:cd03586 160 PPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 250 VEQTYDRDLPDLAACLERLPELLQQLSTRMARldSGYRPGKPFVKLKFHDFTQTTLEQA--GAGLELDDYADLLATAFSR 327
Cdd:cd03586 240 VERTFSEDLTDPEELLEELLELAEELAERLRK--RGLKGRTVTVKLKYADFSTRTRSRTlpEPTDDAEDIYELALELLEE 317
|
330
....*....|....*..
gi 1533180264 328 --RARPVRLIGVGVRLI 342
Cdd:cd03586 318 llDGRPIRLLGVRLSGL 334
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
7-339 |
2.12e-146 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 416.85 E-value: 2.12e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 7 RKIIHIDCDCFYAAIEMRDDPSLARRPIAVGGAAdRRGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYRE 86
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVGGDN-NRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 87 ASREIHEIFRTYTEQIEPLSLDEAYLDVSACEHFAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDGL 166
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 167 FVVTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFGAFGERLWGLAWGIDERPVQVESRRQ 246
Cdd:COG0389 160 TVIPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVEPRRPRK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 247 SVSVEQTYDRDLPDLAACLERLPELLQQLSTRMARldSGYRPGKPFVKLKFHDFTQTTLEQAGAGLeLDDYADLLATA-- 324
Cdd:COG0389 240 SIGVERTFGEDLTDLEELEAALRRLAERLAERLRR--QGLGARTVTVKLRTSDFRTTTRSRTLPEP-TDDTAELLRAAre 316
|
330
....*....|....*....
gi 1533180264 325 ----FSRRARPVRLIGVGV 339
Cdd:COG0389 317 llerIYRPGRPVRLLGVRL 335
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
12-159 |
7.81e-66 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 204.73 E-value: 7.81e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 12 IDCDCFYAAIEMRDDPSLARRPIAVGGAaDRRGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYREASREI 91
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGG-NGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1533180264 92 HEIFRTY-TEQIEPLSLDEAYLDVSACEHFAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASE 159
Cdd:pfam00817 80 FEILRRFsTPKVEQASIDEAFLDLTGLEKLFGAEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| POLXc |
smart00483 |
DNA polymerase X family; includes vertebrate polymerase beta and terminal ... |
166-216 |
4.68e-03 |
|
DNA polymerase X family; includes vertebrate polymerase beta and terminal deoxynucleotidyltransferases
Pssm-ID: 214688 Cd Length: 334 Bit Score: 38.50 E-value: 4.68e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1533180264 166 LFVVTPAQVEEFVKAL-EVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSL 216
Cdd:smart00483 73 SSKVLEILNDEVYKSLkLFTNVFGVGPKTAAKWYRKGIRTLEELKKNKELKL 124
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
14-354 |
0e+00 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 593.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 14 CDCFYAAIEMRDDPSLARRPIAVGGAADRRGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYREASREIHE 93
Cdd:PRK02406 1 MDCFYAAVEMRDNPELRGKPVAVGGSPGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 94 IFRTYTEQIEPLSLDEAYLDVSACEHFAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDGLFVVTPAQ 173
Cdd:PRK02406 81 IFRRYTDLIEPLSLDEAYLDVTDNKLCIGSATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 174 VEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFGAFGERLWGLAWGIDERPVQVESRRQSVSVEQT 253
Cdd:PRK02406 161 VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRRLYERARGIDERPVKPDRERKSVGVERT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 254 YDRDLPDLAACLERLPELLQQLSTRMARLDSGYRPGKPFVKLKFHDFTQTTLEQAGAGLELDDYADLLATAFSRRA--RP 331
Cdd:PRK02406 241 FAEDLYDLEACLAELPRLAEKLERRLERAKPDKRIKTVGVKLKFADFQQTTKEHTADPLDKADLIELLAQALLRRLggRG 320
|
330 340
....*....|....*....|...
gi 1533180264 332 VRLIGVGVRLIDLRGGFEQLRLF 354
Cdd:PRK02406 321 VRLLGVGVTLLEPQLERQLLLDL 343
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
10-342 |
1.14e-168 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 473.16 E-value: 1.14e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 10 IHIDCDCFYAAIEMRDDPSLARRPIAVGGAADRrGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYREASR 89
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSDR-GVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 90 EIHEIFRTYTEQIEPLSLDEAYLDVSACEHFAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDGLFVV 169
Cdd:cd03586 80 QIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 170 TPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFGAFGERLWGLAWGIDERPVQVESRRQSVS 249
Cdd:cd03586 160 PPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 250 VEQTYDRDLPDLAACLERLPELLQQLSTRMARldSGYRPGKPFVKLKFHDFTQTTLEQA--GAGLELDDYADLLATAFSR 327
Cdd:cd03586 240 VERTFSEDLTDPEELLEELLELAEELAERLRK--RGLKGRTVTVKLKYADFSTRTRSRTlpEPTDDAEDIYELALELLEE 317
|
330
....*....|....*..
gi 1533180264 328 --RARPVRLIGVGVRLI 342
Cdd:cd03586 318 llDGRPIRLLGVRLSGL 334
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
7-339 |
2.12e-146 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 416.85 E-value: 2.12e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 7 RKIIHIDCDCFYAAIEMRDDPSLARRPIAVGGAAdRRGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYRE 86
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVGGDN-NRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 87 ASREIHEIFRTYTEQIEPLSLDEAYLDVSACEHFAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDGL 166
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 167 FVVTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFGAFGERLWGLAWGIDERPVQVESRRQ 246
Cdd:COG0389 160 TVIPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVEPRRPRK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 247 SVSVEQTYDRDLPDLAACLERLPELLQQLSTRMARldSGYRPGKPFVKLKFHDFTQTTLEQAGAGLeLDDYADLLATA-- 324
Cdd:COG0389 240 SIGVERTFGEDLTDLEELEAALRRLAERLAERLRR--QGLGARTVTVKLRTSDFRTTTRSRTLPEP-TDDTAELLRAAre 316
|
330
....*....|....*....
gi 1533180264 325 ----FSRRARPVRLIGVGV 339
Cdd:COG0389 317 llerIYRPGRPVRLLGVRL 335
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
7-354 |
2.06e-98 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 297.33 E-value: 2.06e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 7 RKIIHIDCDCFYAAIEMRDDPSLARRPIAVGG-AADRRGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYR 85
Cdd:PRK01810 5 RVIFHVDMNSFFASVEIAYDPSLQGKPLAVAGnEKERKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRYR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 86 EASREIHEIFRTYTEQIEPLSLDEAYLDVSACEHfAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDG 165
Cdd:PRK01810 85 EASRQMFQILSEFTPLVQPVSIDEGYLDITDCYA-LGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 166 LFVVTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFGAFGERLWGLAWGIDERPVQVES-- 243
Cdd:PRK01810 164 ITVLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGIDDRPVDPEAiy 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 244 RRQSVSVEQTYDRDLPDLAACLERLPELLQQLSTRMARLDSGYRpgKPFVKLKFHDFTQTTLEQAGAGlELDDYADLLAT 323
Cdd:PRK01810 244 QFKSVGNSTTLSHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSY--NVQIMIRYHDRRTITRSKTLKN-PIWEKRDIFQA 320
|
330 340 350
....*....|....*....|....*....|....*..
gi 1533180264 324 A---FSRR--ARPVRLIGV-GVRLIDLRGGFEQLRLF 354
Cdd:PRK01810 321 AsrlFKQHwnGDPVRLLGVtATDLEWKTEAVKQLDLF 357
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
9-347 |
1.41e-96 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 292.99 E-value: 1.41e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 9 IIHIDCDCFYAAIEMRDDPSLARRPIAVGGAadRRGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYREAS 88
Cdd:PRK02794 38 IAHIDCDAFYASVEKRDNPELRDKPVIIGGG--KRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 89 REIHEIFRTYTEQIEPLSLDEAYLDVSACEHFAG-SATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDGLF 167
Cdd:PRK02794 116 REVRAMMQALTPLVEPLSIDEAFLDLSGTERLHGaPPAVVLARFARRVEREIGITVSVGLSYNKFLAKIASDLDKPRGFS 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 168 VVTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFGAFGERLWGLAWGIDERPVQVESRRQS 247
Cdd:PRK02794 196 VIGRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGIDDRKVSPDREAKS 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 248 VSVEQTYDRDLPDLAACLERLPELLQQLSTRMARldSGYRPGKPFVKLKFHDFTQTTLEQAgagleLDDYADLLATAFS- 326
Cdd:PRK02794 276 VSAETTFETDLSDFEDLEPILWRLSEKVSRRLKA--AGLAGRTVTLKLKTADFRLRTRRRT-----LEDPTQLADRIFRt 348
|
330 340
....*....|....*....|....*....
gi 1533180264 327 --------RRARPVRLIGVGVRliDLRGG 347
Cdd:PRK02794 349 arellekeTDGTAFRLIGIGVS--DLSPA 375
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
7-339 |
4.88e-87 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 266.20 E-value: 4.88e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 7 RKIIHIDCDCFYAAIEMRDDPSLARRPIAVGGAADRrGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYRE 86
Cdd:PRK14133 3 RVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGISER-GVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 87 ASREIHEIFRTYTEQIEPLSLDEAYLDVSACEHfagSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDGL 166
Cdd:PRK14133 82 VSKNIFKILYEVTPIVEPVSIDEAYLDITNIKE---EPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 167 FVVTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFGAFGERLWGLAWGIDERPVQVESRRQ 246
Cdd:PRK14133 159 KIITEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGIDYREVEVSRERK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 247 SVSVEQTYDRDLPDLAACLERLPELLQQLSTRMARLDSGYRPGKpfVKLKFHDFTQTTLEQAgagleLDDYADL------ 320
Cdd:PRK14133 239 SIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVT--VKIKTSDFQTHTKSKT-----LNDYIRDkeeiyn 311
|
330 340
....*....|....*....|..
gi 1533180264 321 LATAF---SRRARPVRLIGVGV 339
Cdd:PRK14133 312 VACEIlehINIKEPIRLIGLSV 333
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
9-353 |
6.99e-85 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 262.23 E-value: 6.99e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 9 IIHIDCDCFYAAIEMRDDPSLARRPIAVGGaadrrGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYREAS 88
Cdd:PRK03858 6 ILHADLDSFYASVEQRDDPALRGRPVIVGG-----GVVLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 89 REIHEIFRTYTEQIEPLSLDEAYLDVSACEHFAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDGLFV 168
Cdd:PRK03858 81 KAVFEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 169 VTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFG-AFGERLWGLAWGIDERPVQVESRRQS 247
Cdd:PRK03858 161 VPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSLLGpAAGRHLHALAHNRDPRRVETGRRRRS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 248 VSVEQTYDRDlpdlAACLERLPELLQQLSTRMA-RLDSGYRPGKPFV-KLKFHDFTQTT----LEQAGAGLE--LDDYAD 319
Cdd:PRK03858 241 VGAQRALGRG----PNSPAEVDAVVVALVDRVArRMRAAGRTGRTVVlRLRFDDFTRATrshtLPRPTASTAtlLAAARD 316
|
330 340 350
....*....|....*....|....*....|....*
gi 1533180264 320 LLATAFSR-RARPVRLIGVGVRLIDlRGGFEQLRL 353
Cdd:PRK03858 317 LVAAAAPLiAERGLTLVGFAVSNLD-DDGAQQLEL 350
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
7-339 |
2.52e-82 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 257.56 E-value: 2.52e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 7 RKIIHIDCDCFYAAIEMRDDPSLARRPIAVGGAADRrGVIATCNYEARAYGVRSAMASGHALKLCPDL-LILRPRMEAYR 85
Cdd:PRK03348 5 RWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGGR-GVVAGASYEARVFGARSAMPMHQARRLVGNGaVVLPPRFVVYR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 86 EASREIHEIFRTYTEQIEPLSLDEAYLDVSACEHF-AGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPD 164
Cdd:PRK03348 84 AASRRVFDTLRELSPVVEQLSFDEAFVEPAELAGAsAEEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGLAKPD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 165 GLFVVTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFG-AFGERLWGLAWGIDERPVQVES 243
Cdd:PRK03348 164 GIRVVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLGaTVGPALHRLARGIDDRPVAERA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 244 RRQSVSVEQTYDRDLPDLAacleRLPELLQQLSTRMAR--LDSGYRPGKPFVKLKFHDFT----QTTLEQAgagleLDDY 317
Cdd:PRK03348 244 EAKQISAESTFAVDLTTRA----QLREAIERIAEHAHRrlLKDGRGARTVTVKLRKSDFStltrSATLPYA-----TDDA 314
|
330 340
....*....|....*....|....*...
gi 1533180264 318 ADLLATAFsRRAR------PVRLIGVGV 339
Cdd:PRK03348 315 AVLAATAR-RLLLdpdeigPIRLVGVGF 341
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
7-279 |
2.80e-71 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 227.58 E-value: 2.80e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 7 RKIIHIDCDCFYAAIEMRDDPSLARRPIAVGGAADRRGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYRE 86
Cdd:cd01701 47 RIIMHVDFDCFFVSVSIRNRPDLKGKPVAVCHGKGPNSEIASCNYEARSYGIKNGMWVGQAKKLCPQLVTLPYDFEAYEE 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 87 ASREIHEIFRTYTEQIEPLSLDEAYLDVSA-CEHFAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDG 165
Cdd:cd01701 127 VSLTFYEILASYTDNIEAVSCDEALIDITSlLEETYELPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAKPDG 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 166 LFVVTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSD--LREWGRLSLVREFGA-FGERLWGLAWGIDERPVQVE 242
Cdd:cd01701 207 QYHLSAEKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGleLRSKTKEKLQKVLGPkTGEKLYDYCRGIDDRPVTGE 286
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1533180264 243 SRRQSVSVEQTYD---RDLPDLAACLERlpeLLQQLSTRM 279
Cdd:cd01701 287 KERKSVSAEINYGirfTNVDDVEQFLQR---LSEELSKRL 323
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
12-159 |
7.81e-66 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 204.73 E-value: 7.81e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 12 IDCDCFYAAIEMRDDPSLARRPIAVGGAaDRRGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYREASREI 91
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGG-NGRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1533180264 92 HEIFRTY-TEQIEPLSLDEAYLDVSACEHFAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASE 159
Cdd:pfam00817 80 FEILRRFsTPKVEQASIDEAFLDLTGLEKLFGAEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
11-285 |
4.24e-64 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 207.21 E-value: 4.24e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 11 HIDCDCFYAAIEMRDDPSLARRPIAVGGAADRRGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYREASRE 90
Cdd:cd00424 2 HIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 91 IHEIFRTYTEQIEPLSLDEAYLDVSACEHFAGSATRIAEDIRRRVWQQLR-ITVSAGVAPNKFLAKIASEWNKPDGLFVV 169
Cdd:cd00424 82 LLSELEEVAPLVEVASIDELFLDLTGSARLLGLGSEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAKPDGLTIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 170 TPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVRE-FGAFGERLWGLAWGIDERPVQVESRRQSV 248
Cdd:cd00424 162 DPEDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALLALwGGVSGERLWYALRGIDDEPLSPPRPRKSF 241
|
250 260 270
....*....|....*....|....*....|....*..
gi 1533180264 249 SVEQTYDRDLPDLAACLERLPELLQQLSTRMARLDSG 285
Cdd:cd00424 242 SHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRG 278
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
7-339 |
7.20e-63 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 206.01 E-value: 7.20e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 7 RKIIHIDCDCFYAAIEMRDDPSLARRPIAVGGAADRR-GVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYR 85
Cdd:PRK03103 3 RVILLVDMQSFYASVEKAANPELKGRPVIVSGDPERRsGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRYI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 86 EASREIHEIFRTYTEQIEPLSLDEAYLDVSACEHFAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASE---WNK 162
Cdd:PRK03103 83 DVSLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFGSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDnfaKKN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 163 PDGLFVVTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFGAFGERLWGLAWGIDERPVQVE 242
Cdd:PRK03103 163 PDGLFTLDKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANGIDYSPVTPH 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 243 S--RRQSVSVEQTYDRDLPDLAACLERLPELLQQLSTRmARLDsGYRPGKPFVKLKFHDF-TQTTLEQAGAGLELDDYA- 318
Cdd:PRK03103 243 SldRQKAIGHQMTLPRDYRGFEEIKVVLLELCEEVCRR-ARAK-GYMGRTVSVSLRGADFdWPTGFSRQMTLPEPTNLAm 320
|
330 340
....*....|....*....|....*.
gi 1533180264 319 DLLATA---FSR--RARPVRLIGVGV 339
Cdd:PRK03103 321 EVYEAAcklFHRhwDGKPVRRVGVTL 346
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
10-279 |
1.94e-52 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 177.66 E-value: 1.94e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 10 IHIDCDCFYAAIEMRDDPSLARRPIAVggaaDRRGVIATCNYEARAYGVRSAMASGHALKLCPDL-LILRPRMEAYREAS 88
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGI----QQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLvLVNGEDLTPFRDMS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 89 REIHEIFRTYT--EQIEPLSLDEAYLDVSACEHFAGSatRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDG- 165
Cdd:cd01703 77 KKVYRLLRSYSwnDRVERLGFDENFMDVTEMRLLVAS--HIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQq 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 166 --LFVVTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLRE---------------WGRLSLVREFG-AFGERL 227
Cdd:cd01703 155 ttLLPPSCADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEfsnrnrqtvgaapslLELLLMVKEFGeGIGQRI 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1533180264 228 WGLAWGIDERPVQVESRR-QSVSVEQTYDR-DLPDLAACLERLPELLQQLSTRM 279
Cdd:cd01703 235 WKLLFGRDTSPVKPASDFpQQISIEDSYKKcSLEEIREARNKIEELLASLLERM 288
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
4-341 |
1.40e-51 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 174.83 E-value: 1.40e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 4 TALRKIIHIDCDCFYAAIEMRDDPSLARRPIAVGGAAD---RRGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPR 80
Cdd:PRK03352 2 AMPRWVLHVDLDQFIAAVELLRRPELAGLPVIVGGNGDptePRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 81 MEAYREASREIHEIFRTYTEQIEPLSLDEAYLDVSACEHFAgsatrIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEW 160
Cdd:PRK03352 82 PAAYDAASEEVMATLRDLGVPVEVWGWDEAFLGVDTDDPEA-----LAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 161 NKPDGLFVVTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFG-AFGERLWGLAWGIDERPV 239
Cdd:PRK03352 157 AKPAGVFRLTDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpTTGPWLLLLARGGGDTEV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 240 QVESR-RQSVSVEQTYDRDLPDLAACLERLPELLQQLSTRMArlDSGYRPGKPFVKLKFHDF-TQTTL----EQAGAGLE 313
Cdd:PRK03352 237 SAEPWvPRSRSREVTFPQDLTDRAEVESAVRELARRVLDEVV--AEGRPVTRVAVKVRTATFyTRTKIrklpEPTTDPDV 314
|
330 340
....*....|....*....|....*...
gi 1533180264 314 LDDYADLLATAFSRRaRPVRLIGVGVRL 341
Cdd:PRK03352 315 IEAAALDVLDRFELD-RPVRLLGVRLEL 341
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
9-208 |
8.70e-51 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 172.67 E-value: 8.70e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 9 IIHIDCDCFYAAIEMRDDPSLARRPIAV---GGAADRRGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYR 85
Cdd:PRK01216 3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVcvySGRFEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 86 EASREIHEIFRTYTEQIEPLSLDEAYLDVSACEHFAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDG 165
Cdd:PRK01216 83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNG 162
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1533180264 166 LFVVTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDL 208
Cdd:PRK01216 163 IKVIDDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDT 205
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
12-281 |
3.12e-50 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 171.19 E-value: 3.12e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 12 IDCDCFYAAIEMRDDPSLARRPIAVGGAADRRgVIATCNyEARAYGVrsAMASghALKLCPDLL------ILRPRMEAYR 85
Cdd:cd01700 3 VDCNSFYASCERVFRPLLLGRPLVVLSNNDGC-VIARSP-EAKALGI--KMGS--PYFKVPDLLerhgvaVFSSNYALYG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 86 EASREIHEIFRTYTEQIEPLSLDEAYLDVSACEHFaGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIASE----WN 161
Cdd:cd01700 77 DMSRRIMSILERFSPDVEVYSIDESFLDLTGSLRF-GDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDlakkKN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 162 KPDGLFVVTPAQVEEFV-KALEVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFGAFGERLWGLAWGIDERPV- 239
Cdd:cd01700 156 PYGGVVDLTDEEVRDKLlKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLe 235
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1533180264 240 QVESRRQSVSVEQTYDRDlpdlaacLERLPELLQQLSTRMAR 281
Cdd:cd01700 236 EYPPPKKSIGSSRSFGRD-------VTDLDELKQALAEYAER 270
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
11-240 |
3.17e-44 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 155.55 E-value: 3.17e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 11 HIDCDCFYAAIEMRDDPSLARRPIAVggaADRRGVIATcNYEARAYGVRSAMASGHALKLCPDLLILRPR---------- 80
Cdd:cd01702 2 HIDMDAFFAQVEQVRLGLLRNDPVAV---VQWNSIIAV-SYAARAFGVTRFMTIDEAKKKCPDLILAHVAtykkgedead 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 81 -------------MEAYREASREIHEIFRTYTEQIEPLSLDEAYLDVSAcehfagsatRIAEDIRRRVWQQLRITVSAGV 147
Cdd:cd01702 78 yhenpsparhkvsLDPYRRASRKILNILKRFGDVVEKASIDEAYLDLGS---------RIVEEIRQQVYDELGYTCSAGI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 148 APNKFLAKIASEWNKPDGLFVVTPAQVEEFVKALEVKRLHG----VGRVTAEKLGRLGIRTCSDLREWGRLSLVREFGAF 223
Cdd:cd01702 149 AHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLPITSIRGlggkLGEEIIDLLGLPTEGDVAGFRSSESDLQEHFGEKL 228
|
250
....*....|....*..
gi 1533180264 224 GERLWGLAWGIDERPVQ 240
Cdd:cd01702 229 GEWLYNLLRGIDHEPVK 245
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
10-208 |
6.40e-42 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 153.64 E-value: 6.40e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 10 IHIDCDCFYAAIEMRDDPSLARRPIAVGGAAdrrgVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYREASR 89
Cdd:PTZ00205 136 IHLDMDMFYAAVEIKKHPEYAAIPLAIGTMT----MLQTANYVARGRGIRQGMPGFLALKICPNLLILPPDFDAYNEESN 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 90 EIHEIFRTYTEQIEPLSLDEAYLDVSA-CEHFAGSATR--IAEDIRRRVWQQLRITVSAGVAPNKFLAKIASEWNKPDG- 165
Cdd:PTZ00205 212 TVRRIVAEYDPNYISFGLDELTLEVSAyIERFEGTKTAedVASELRVRVFGETKLTASAGIGPTAALAKIASNINKPNGq 291
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1533180264 166 --LFVVTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDL 208
Cdd:PTZ00205 292 hdLNLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDI 336
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
24-281 |
2.20e-23 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 98.99 E-value: 2.20e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 24 RDDPSLARRPIAVGgAADRRGVIATCNYEARAYGVRSAMASGHALKLCPDLLILRPRMEAYREASREIHEIFRTYTEQIE 103
Cdd:cd03468 15 RNRPADDEAPLAVV-ERKKAGRILACNAAARAAGVRPGMPLAEALALCPNLQVVEYDPEADARALQELALWLLRFTPLVA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 104 PLSLDEAYLDVSACEHFAGSATRIAEDIRRRVwQQLRITVSAGVAPNKFLAKIASEWNKPDGLFVVTPAQVEEFVKALEV 183
Cdd:cd03468 94 LDGPDGLLLDVTGCLHLFGGEDALAASLRAAL-ATLGLSARAGIADTPGAAWLLARAGGGRGVLRREALAAALVLLAPLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 184 KRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSLVREFGAFGERLWGLAWGIDERPVQVESRRQS--VSVEQTYDRDLPDL 261
Cdd:cd03468 173 VAALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGRDPEPLLFSPPPPAfdFRLELQLEEPIARG 252
|
250 260
....*....|....*....|
gi 1533180264 262 AacLERLPELLQQLSTRMAR 281
Cdd:cd03468 253 L--LFPLRRLLEQLCAFLAL 270
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
11-210 |
8.34e-14 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 72.11 E-value: 8.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 11 HIDCDCFYAAIEMRDDPSLARRPIAVGGAADrrGVIATCNYEARAYGVRSAMA--SGHALKLCPDLLILRPRMEAYREAS 88
Cdd:PRK03609 4 LCDVNSFYASCETVFRPDLRGKPVVVLSNND--GCVIARSAEAKALGIKMGDPwfKQKDLFRRCGVVCFSSNYELYADMS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 89 REIHEIFRTYTEQIEPLSLDEAYLDVSACEHfAGSATRIAEDIRRRVWQQLRITVSAGVAPNKFLAKIAS----EWNKPD 164
Cdd:PRK03609 82 NRVMSTLEELSPRVEIYSIDEAFCDLTGVRN-CRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANhaakKWQRQT 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1533180264 165 G--LFVVTPAQVEEFVKALEVKRLHGVGRVTAEKLGRLGIRTCSDLRE 210
Cdd:PRK03609 161 GgvVDLSNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLAD 208
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
245-339 |
1.02e-11 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 60.65 E-value: 1.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533180264 245 RQSVSVEQTYDRDLPDLAACLERLPELLQQLSTRMARLdsGYRPGKPFVKLKFHDFT----QTTLEQAgagleLDDYADL 320
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQ--GLVARTVTVKIRYSDFRtitrSVTLPSP-----TDDTDEI 73
|
90 100
....*....|....*....|....
gi 1533180264 321 LATAFSR-----RARPVRLIGVGV 339
Cdd:pfam11799 74 YRAALRLlrrlyRGRPVRLLGVSL 97
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
171-202 |
6.27e-05 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 39.69 E-value: 6.27e-05
10 20 30
....*....|....*....|....*....|..
gi 1533180264 171 PAQVEEFVKALEVKRLHGVGRVTAEKLGRLGI 202
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| DNA_pol_lambd_f |
pfam10391 |
Fingers domain of DNA polymerase lambda; DNA polymerases catalyze the addition of dNMPs onto ... |
187-216 |
2.02e-03 |
|
Fingers domain of DNA polymerase lambda; DNA polymerases catalyze the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone.
Pssm-ID: 463069 [Multi-domain] Cd Length: 51 Bit Score: 35.89 E-value: 2.02e-03
10 20 30
....*....|....*....|....*....|
gi 1533180264 187 HGVGRVTAEKLGRLGIRTCSDLREWGRLSL 216
Cdd:pfam10391 7 YGVGPTTARKWYAQGYRTLDDLREKKTAKL 36
|
|
| POLXc |
smart00483 |
DNA polymerase X family; includes vertebrate polymerase beta and terminal ... |
166-216 |
4.68e-03 |
|
DNA polymerase X family; includes vertebrate polymerase beta and terminal deoxynucleotidyltransferases
Pssm-ID: 214688 Cd Length: 334 Bit Score: 38.50 E-value: 4.68e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1533180264 166 LFVVTPAQVEEFVKAL-EVKRLHGVGRVTAEKLGRLGIRTCSDLREWGRLSL 216
Cdd:smart00483 73 SSKVLEILNDEVYKSLkLFTNVFGVGPKTAAKWYRKGIRTLEELKKNKELKL 124
|
|
|