|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08673 |
PRK08673 |
3-deoxy-7-phosphoheptulonate synthase; Reviewed |
2-335 |
0e+00 |
|
3-deoxy-7-phosphoheptulonate synthase; Reviewed
Pssm-ID: 181535 [Multi-domain] Cd Length: 335 Bit Score: 548.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 2 IVIMKKEATEEQIKKVVDHIEKEGFKVSIDQGTERVVIGLKGDTRSLQEGAFTRYEGVENAVRILNTYKLTSREFHPGNT 81
Cdd:PRK08673 1 IIVMKPGATEEEIDEVIEEVESAGLKTHVSPGVERTVIGLIGDKGKVDAAKFEALPGVEEVVPVLKPYKLASREFKPEPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 82 VVDVDGVKIGDGSFVTMAGPCSIEGLDQIRECARMAKAGGAKILRGGAFKPRTSPYAFQGLEEEGLKYIRQAADEFGMKV 161
Cdd:PRK08673 81 VVKVGDVEIGGGKPVVIAGPCSVESEEQILEIARAVKEAGAQILRGGAFKPRTSPYSFQGLGEEGLKLLAEAREETGLPI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 162 ITEVMDEGHIDMVAEYSDILQIGARNMQNFKLLSAVGKTGKPVGLKRGISGTINEWLNAAEYIAVEDKSPVIFIERGIRT 241
Cdd:PRK08673 161 VTEVMDPRDVELVAEYVDILQIGARNMQNFDLLKEVGKTNKPVLLKRGMSATIEEWLMAAEYILAEGNPNVILCERGIRT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 242 YETATRNTFDLSAVPLMKKLTHFPVIVDPSHGTGIWELVPPMARAGVASGADGMIVEIHPDPANAWSDGPQSLNEKTYSR 321
Cdd:PRK08673 241 FETATRNTLDLSAVPVIKKLTHLPVIVDPSHATGKRDLVEPLALAAVAAGADGLIVEVHPDPEKALSDGPQSLTPEEFEE 320
|
330
....*....|....
gi 1533683560 322 MMKEVAIMKEAMEK 335
Cdd:PRK08673 321 LMKKLRAIAEALGR 334
|
|
| AroGA |
COG2876 |
3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and ... |
57-335 |
0e+00 |
|
3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 442123 Cd Length: 283 Bit Score: 529.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 57 EGVENAVRILNTYKLTSREFHPGNTVVDVDGVKIGDGSFVTMAGPCSIEGLDQIRECARMAKAGGAKILRGGAFKPRTSP 136
Cdd:COG2876 3 PGVEKVVRVSKPYKLASREFKPEDTVVDVGGVKIGGGELVVIAGPCAVESEEQILETAKAVKAAGAKILRGGAFKPRTSP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 137 YAFQGLEEEGLKYIRQAADEFGMKVITEVMDEGHIDMVAEYSDILQIGARNMQNFKLLSAVGKTGKPVGLKRGISGTINE 216
Cdd:COG2876 83 YSFQGLGEEGLKLLAEAREETGLPVVTEVMDPRDVELVAEYADILQIGARNMQNFELLKEVGRTGKPVLLKRGLSATIEE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 217 WLNAAEYIAVEDKSPVIFIERGIRTYETATRNTFDLSAVPLMKKLTHFPVIVDPSHGTGIWELVPPMARAGVASGADGMI 296
Cdd:COG2876 163 WLMAAEYILSEGNPNVILCERGIRTFETATRNTLDLSAVPVLKELTHLPVIVDPSHATGRRDLVPPMAKAAVAAGADGLM 242
|
250 260 270
....*....|....*....|....*....|....*....
gi 1533683560 297 VEIHPDPANAWSDGPQSLNEKTYSRMMKEVAIMKEAMEK 335
Cdd:COG2876 243 IEVHPDPEKALSDGPQSLTPEEFAELMEELRKLAEAVGR 281
|
|
| DAHP_synth_Bsub |
TIGR01361 |
3-deoxy-7-phosphoheptulonate synthase; This model describes one of at least three types of ... |
70-329 |
1.56e-162 |
|
3-deoxy-7-phosphoheptulonate synthase; This model describes one of at least three types of phospho-2-dehydro-3-deoxyheptonate aldolase (DAHP synthase). This enzyme catalyzes the first of 7 steps in the biosynthesis of chorismate, that last common precursor of all three aromatic amino acids and of PABA, ubiquinone and menaquinone. Some members of this family, including an experimentally characterized member from Bacillus subtilis, are bifunctional, with a chorismate mutase domain N-terminal to this region. The member of this family from Synechocystis PCC 6803, CcmA, was shown to be essential for carboxysome formation. However, no other candidate for this enzyme is present in that species, chorismate biosynthesis does occur, other species having this protein lack carboxysomes but appear to make chorismate, and a requirement of CcmA for carboxysome formation does not prohibit a role in chorismate biosynthesis. [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273577 Cd Length: 260 Bit Score: 454.11 E-value: 1.56e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 70 KLTSREFHPGNTVVDVDGVKIGDGSFVTMAGPCSIEGLDQIRECARMAKAGGAKILRGGAFKPRTSPYAFQGLEEEGLKY 149
Cdd:TIGR01361 1 KLVSRKFHPEKTVVDVGGVKIGEGSPIVIAGPCSVESEEQIMETARFVKEAGAKILRGGAFKPRTSPYSFQGLGEEGLKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 150 IRQAADEFGMKVITEVMDEGHIDMVAEYSDILQIGARNMQNFKLLSAVGKTGKPVGLKRGISGTINEWLNAAEYIAVEDK 229
Cdd:TIGR01361 81 LRRAADEHGLPVVTEVMDPRDVEIVAEYADILQIGARNMQNFELLKEVGKQGKPVLLKRGMGNTIEEWLYAAEYILSSGN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 230 SPVIFIERGIRTYETATRNTFDLSAVPLMKKLTHFPVIVDPSHGTGIWELVPPMARAGVASGADGMIVEIHPDPANAWSD 309
Cdd:TIGR01361 161 GNVILCERGIRTFEKATRNTLDLSAVPVLKKETHLPIIVDPSHAAGRRDLVIPLAKAAIAAGADGLMIEVHPDPEKALSD 240
|
250 260
....*....|....*....|
gi 1533683560 310 GPQSLNEKTYSRMMKEVAIM 329
Cdd:TIGR01361 241 SKQQLTPEEFKRLVKELRAL 260
|
|
| DAHP_synth_1 |
pfam00793 |
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ... |
80-314 |
2.20e-86 |
|
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.
Pssm-ID: 395641 Cd Length: 271 Bit Score: 261.10 E-value: 2.20e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 80 NTVVDVD-GVKIGDGS-FVTMAGPCSIEGLDQIRECARMAKAGGAK---ILRGGAF--KPRTSPYAFQGL-EEEGLKYIR 151
Cdd:pfam00793 1 DIPISLKqDIIIGKDDrLLVIAGPCSIEDPEAAMEYARRLKKLGAKlklIIIMRAYfeKPRTSPVGFKGLgNDPDLNILF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 152 QAADEFGMKVITEVMDEGHIDMVAEYSDILQIGARNMQNFKLLSAVGKTGKPVGLKRGISGTINEWLNAAEYIAVEDKSP 231
Cdd:pfam00793 81 RIKDGLGLPIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGTDAAIDEMLAAAEYHLFLGVTK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 232 -VIFIERGIRTYETATRNTFDLSAVPLMKKLT-HFPVIVDPSHGTG-----IWELVPPMARAGVASGADGMIVEIHPDPA 304
Cdd:pfam00793 161 gNILCERGIRGGEGPNRNTLDVSAVAILKEETgHLPVMVDVSHANGrkdggRQPLVLPLAKAAIAVGIDGLMIEVHPNPG 240
|
250
....*....|
gi 1533683560 305 NAWSDGPQSL 314
Cdd:pfam00793 241 NALSDGPQQL 250
|
|
| IGPS |
cd00331 |
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ... |
142-193 |
6.42e-03 |
|
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.
Pssm-ID: 238203 Cd Length: 217 Bit Score: 37.44 E-value: 6.42e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1533683560 142 LEEEGLKYIRQAADEFGMKVITEVMDEGHIDMVAEYS-DILQIGARNMQNFKL 193
Cdd:cd00331 105 LDDEQLKELYELARELGMEVLVEVHDEEELERALALGaKIIGINNRDLKTFEV 157
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08673 |
PRK08673 |
3-deoxy-7-phosphoheptulonate synthase; Reviewed |
2-335 |
0e+00 |
|
3-deoxy-7-phosphoheptulonate synthase; Reviewed
Pssm-ID: 181535 [Multi-domain] Cd Length: 335 Bit Score: 548.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 2 IVIMKKEATEEQIKKVVDHIEKEGFKVSIDQGTERVVIGLKGDTRSLQEGAFTRYEGVENAVRILNTYKLTSREFHPGNT 81
Cdd:PRK08673 1 IIVMKPGATEEEIDEVIEEVESAGLKTHVSPGVERTVIGLIGDKGKVDAAKFEALPGVEEVVPVLKPYKLASREFKPEPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 82 VVDVDGVKIGDGSFVTMAGPCSIEGLDQIRECARMAKAGGAKILRGGAFKPRTSPYAFQGLEEEGLKYIRQAADEFGMKV 161
Cdd:PRK08673 81 VVKVGDVEIGGGKPVVIAGPCSVESEEQILEIARAVKEAGAQILRGGAFKPRTSPYSFQGLGEEGLKLLAEAREETGLPI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 162 ITEVMDEGHIDMVAEYSDILQIGARNMQNFKLLSAVGKTGKPVGLKRGISGTINEWLNAAEYIAVEDKSPVIFIERGIRT 241
Cdd:PRK08673 161 VTEVMDPRDVELVAEYVDILQIGARNMQNFDLLKEVGKTNKPVLLKRGMSATIEEWLMAAEYILAEGNPNVILCERGIRT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 242 YETATRNTFDLSAVPLMKKLTHFPVIVDPSHGTGIWELVPPMARAGVASGADGMIVEIHPDPANAWSDGPQSLNEKTYSR 321
Cdd:PRK08673 241 FETATRNTLDLSAVPVIKKLTHLPVIVDPSHATGKRDLVEPLALAAVAAGADGLIVEVHPDPEKALSDGPQSLTPEEFEE 320
|
330
....*....|....
gi 1533683560 322 MMKEVAIMKEAMEK 335
Cdd:PRK08673 321 LMKKLRAIAEALGR 334
|
|
| AroGA |
COG2876 |
3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and ... |
57-335 |
0e+00 |
|
3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 442123 Cd Length: 283 Bit Score: 529.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 57 EGVENAVRILNTYKLTSREFHPGNTVVDVDGVKIGDGSFVTMAGPCSIEGLDQIRECARMAKAGGAKILRGGAFKPRTSP 136
Cdd:COG2876 3 PGVEKVVRVSKPYKLASREFKPEDTVVDVGGVKIGGGELVVIAGPCAVESEEQILETAKAVKAAGAKILRGGAFKPRTSP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 137 YAFQGLEEEGLKYIRQAADEFGMKVITEVMDEGHIDMVAEYSDILQIGARNMQNFKLLSAVGKTGKPVGLKRGISGTINE 216
Cdd:COG2876 83 YSFQGLGEEGLKLLAEAREETGLPVVTEVMDPRDVELVAEYADILQIGARNMQNFELLKEVGRTGKPVLLKRGLSATIEE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 217 WLNAAEYIAVEDKSPVIFIERGIRTYETATRNTFDLSAVPLMKKLTHFPVIVDPSHGTGIWELVPPMARAGVASGADGMI 296
Cdd:COG2876 163 WLMAAEYILSEGNPNVILCERGIRTFETATRNTLDLSAVPVLKELTHLPVIVDPSHATGRRDLVPPMAKAAVAAGADGLM 242
|
250 260 270
....*....|....*....|....*....|....*....
gi 1533683560 297 VEIHPDPANAWSDGPQSLNEKTYSRMMKEVAIMKEAMEK 335
Cdd:COG2876 243 IEVHPDPEKALSDGPQSLTPEEFAELMEELRKLAEAVGR 281
|
|
| DAHP_synth_Bsub |
TIGR01361 |
3-deoxy-7-phosphoheptulonate synthase; This model describes one of at least three types of ... |
70-329 |
1.56e-162 |
|
3-deoxy-7-phosphoheptulonate synthase; This model describes one of at least three types of phospho-2-dehydro-3-deoxyheptonate aldolase (DAHP synthase). This enzyme catalyzes the first of 7 steps in the biosynthesis of chorismate, that last common precursor of all three aromatic amino acids and of PABA, ubiquinone and menaquinone. Some members of this family, including an experimentally characterized member from Bacillus subtilis, are bifunctional, with a chorismate mutase domain N-terminal to this region. The member of this family from Synechocystis PCC 6803, CcmA, was shown to be essential for carboxysome formation. However, no other candidate for this enzyme is present in that species, chorismate biosynthesis does occur, other species having this protein lack carboxysomes but appear to make chorismate, and a requirement of CcmA for carboxysome formation does not prohibit a role in chorismate biosynthesis. [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273577 Cd Length: 260 Bit Score: 454.11 E-value: 1.56e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 70 KLTSREFHPGNTVVDVDGVKIGDGSFVTMAGPCSIEGLDQIRECARMAKAGGAKILRGGAFKPRTSPYAFQGLEEEGLKY 149
Cdd:TIGR01361 1 KLVSRKFHPEKTVVDVGGVKIGEGSPIVIAGPCSVESEEQIMETARFVKEAGAKILRGGAFKPRTSPYSFQGLGEEGLKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 150 IRQAADEFGMKVITEVMDEGHIDMVAEYSDILQIGARNMQNFKLLSAVGKTGKPVGLKRGISGTINEWLNAAEYIAVEDK 229
Cdd:TIGR01361 81 LRRAADEHGLPVVTEVMDPRDVEIVAEYADILQIGARNMQNFELLKEVGKQGKPVLLKRGMGNTIEEWLYAAEYILSSGN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 230 SPVIFIERGIRTYETATRNTFDLSAVPLMKKLTHFPVIVDPSHGTGIWELVPPMARAGVASGADGMIVEIHPDPANAWSD 309
Cdd:TIGR01361 161 GNVILCERGIRTFEKATRNTLDLSAVPVLKKETHLPIIVDPSHAAGRRDLVIPLAKAAIAAGADGLMIEVHPDPEKALSD 240
|
250 260
....*....|....*....|
gi 1533683560 310 GPQSLNEKTYSRMMKEVAIM 329
Cdd:TIGR01361 241 SKQQLTPEEFKRLVKELRAL 260
|
|
| PRK12595 |
PRK12595 |
bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed |
71-335 |
1.23e-131 |
|
bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed
Pssm-ID: 183614 [Multi-domain] Cd Length: 360 Bit Score: 379.71 E-value: 1.23e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 71 LTSREFHPGNTVVDVDGVKIGDGSFVTMAGPCSIEGLDQIRECARMAKAGGAKILRGGAFKPRTSPYAFQGLEEEGLKYI 150
Cdd:PRK12595 95 LVSRKKKPEDTIVDVKGEVIGDGNQSFIFGPCSVESYEQVEAVAKALKAKGLKLLRGGAFKPRTSPYDFQGLGVEGLKIL 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 151 RQAADEFGMKVITEVMDEGHIDMVAEYSDILQIGARNMQNFKLLSAVGKTGKPVGLKRGISGTINEWLNAAEYIAVEDKS 230
Cdd:PRK12595 175 KQVADEYGLAVISEIVNPADVEVALDYVDVIQIGARNMQNFELLKAAGRVNKPVLLKRGLSATIEEFIYAAEYIMSQGNG 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 231 PVIFIERGIRTYETATRNTFDLSAVPLMKKLTHFPVIVDPSHGTGIWELVPPMARAGVASGADGMIVEIHPDPANAWSDG 310
Cdd:PRK12595 255 QIILCERGIRTYEKATRNTLDISAVPILKQETHLPVMVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPAVALSDS 334
|
250 260
....*....|....*....|....*
gi 1533683560 311 PQSLNEKTYSRMMKEVAIMKEAMEK 335
Cdd:PRK12595 335 AQQMDIPEFDRFLDELKPLANKLNA 359
|
|
| PRK13396 |
PRK13396 |
3-deoxy-7-phosphoheptulonate synthase; Provisional |
1-335 |
3.46e-120 |
|
3-deoxy-7-phosphoheptulonate synthase; Provisional
Pssm-ID: 237376 [Multi-domain] Cd Length: 352 Bit Score: 350.21 E-value: 3.46e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 1 MIVIMKKEATEEQIKKVVDHIEKEGFKVSIDQGTERVVIGLKGDTRSLQEGAFTRYEG-VENAVRILNTYKLTSREFHPG 79
Cdd:PRK13396 1 MIIVMKVGTPEAEIERISQELTSWGLTPEKIVGKHKVVIGLVGDTAELDPLQIQELSPwIEQVLRVEKPFKRASREYRHG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 80 N---TVVDV-DG-VKIGDG-SFVTMAGPCSIEGLDQIRECARMAKAGGAKILRGGAFKPRTSPYAFQGLEEEGLKYIRQA 153
Cdd:PRK13396 81 EaseVVVPTpNGpVPFGENhPVVVVAGPCSVENEEMIVETAKRVKAAGAKFLRGGAYKPRTSPYAFQGHGESALELLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 154 ADEFGMKVITEVMDEGHIDMVAEYSDILQIGARNMQNFKLLSAVGKTGKPVGLKRGISGTINEWLNAAEYIAVEDKSPVI 233
Cdd:PRK13396 161 REATGLGIITEVMDAADLEKIAEVADVIQVGARNMQNFSLLKKVGAQDKPVLLKRGMAATIDEWLMAAEYILAAGNPNVI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 234 FIERGIRTYETA-TRNTFDLSAVPLMKKLTHFPVIVDPSHGTGIWELVPPMARAGVASGADGMIVEIHPDPANAWSDGPQ 312
Cdd:PRK13396 241 LCERGIRTFDRQyTRNTLDLSVIPVLRSLTHLPIMIDPSHGTGKSEYVPSMAMAAIAAGTDSLMIEVHPNPAKALSDGPQ 320
|
330 340
....*....|....*....|...
gi 1533683560 313 SLNEKTYSRMMKEVAIMKEAMEK 335
Cdd:PRK13396 321 SLTPDRFDRLMQELAVIGKTVGR 343
|
|
| DAHP_synth_1 |
pfam00793 |
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino ... |
80-314 |
2.20e-86 |
|
DAHP synthetase I family; Members of this family catalyze the first step in aromatic amino acid biosynthesis from chorismate. E-coli has three related synthetases, which are inhibited by different aromatic amino acids. This family also includes KDSA which has very similar catalytic activity but is involved in the first step of liposaccharide biosynthesis. The enzyme is also part of the shikimate pathway, EC:2.5.1.54.
Pssm-ID: 395641 Cd Length: 271 Bit Score: 261.10 E-value: 2.20e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 80 NTVVDVD-GVKIGDGS-FVTMAGPCSIEGLDQIRECARMAKAGGAK---ILRGGAF--KPRTSPYAFQGL-EEEGLKYIR 151
Cdd:pfam00793 1 DIPISLKqDIIIGKDDrLLVIAGPCSIEDPEAAMEYARRLKKLGAKlklIIIMRAYfeKPRTSPVGFKGLgNDPDLNILF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 152 QAADEFGMKVITEVMDEGHIDMVAEYSDILQIGARNMQNFKLLSAVGKTGKPVGLKRGISGTINEWLNAAEYIAVEDKSP 231
Cdd:pfam00793 81 RIKDGLGLPIATEVLDPIDPQYLADVVDIGQIGARTTESQDLLELAGGLSKPVGFKNGTDAAIDEMLAAAEYHLFLGVTK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 232 -VIFIERGIRTYETATRNTFDLSAVPLMKKLT-HFPVIVDPSHGTG-----IWELVPPMARAGVASGADGMIVEIHPDPA 304
Cdd:pfam00793 161 gNILCERGIRGGEGPNRNTLDVSAVAILKEETgHLPVMVDVSHANGrkdggRQPLVLPLAKAAIAVGIDGLMIEVHPNPG 240
|
250
....*....|
gi 1533683560 305 NAWSDGPQSL 314
Cdd:pfam00793 241 NALSDGPQQL 250
|
|
| KdsA |
COG2877 |
3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope ... |
85-314 |
8.05e-39 |
|
3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope biogenesis]; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase is part of the Pathway/BioSystem: Lipid A biosynthesis
Pssm-ID: 442124 Cd Length: 265 Bit Score: 138.24 E-value: 8.05e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 85 VDGVKIGDGS-FVTMAGPCSIEGLDQIRECA----RMAKAGGAKILrggaFKP------RTSPYAFQGL-EEEGLKYIRQ 152
Cdd:COG2877 1 IGGIEVGNDKpLFLIAGPCVIESEDLALEIAeklkEITDKLGIPYI----FKAsfdkanRSSIDSFRGPgLEEGLKILAE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 153 AADEFGMKVITEVMDEGHIDMVAEYSDILQIGArnmqnF-----KLLSAVGKTGKPVGLKRGisgtinEWL------NAA 221
Cdd:COG2877 77 VKEEFGVPVLTDVHEPEQAAPVAEVVDVLQIPA-----FlcrqtDLLVAAAKTGKVVNVKKG------QFLapwdmkNVV 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 222 EYIAVEDKSPVIFIERGirtyetatrNTF-------DLSAVPLMKKlTHFPVIVDPSH--------GT---GIWELVPPM 283
Cdd:COG2877 146 EKVREAGNDNILLTERG---------TSFgynnlvvDMRSLPIMRE-TGYPVVFDATHsvqlpggqGGssgGQREFVPVL 215
|
250 260 270
....*....|....*....|....*....|.
gi 1533683560 284 ARAGVASGADGMIVEIHPDPANAWSDGPQSL 314
Cdd:COG2877 216 ARAAVAVGVDGLFMETHPDPDKALSDGPNML 246
|
|
| PRK05198 |
PRK05198 |
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional |
87-314 |
1.15e-38 |
|
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
Pssm-ID: 235363 Cd Length: 264 Bit Score: 137.91 E-value: 1.15e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 87 GVKIG-DGSFVTMAGPCSIEGLDQIRECARMAKAGGAKILRGGAFKP------RTSPYAFQGL-EEEGLKYIRQAADEFG 158
Cdd:PRK05198 2 DIEVGnDLPFFLIAGPCVIESRDLALRIAEHLKEITDKLGIPYVFKAsfdkanRSSIHSFRGPgLEEGLKILQEVKETFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 159 MKVITEVMDEGHIDMVAEYSDILQIGArnmqnF-----KLLSAVGKTGKPVGLKRGisgtinEWL------NAAEYIAVE 227
Cdd:PRK05198 82 VPVLTDVHEPEQAAPVAEVVDVLQIPA-----FlcrqtDLLVAAAKTGKVVNIKKG------QFLapwdmkNVVDKVREA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 228 DKSPVIFIERGirtyetatrNTF-------DLSAVPLMKKlTHFPVIVDPSH--------GT---GIWELVPPMARAGVA 289
Cdd:PRK05198 151 GNDKIILCERG---------TSFgynnlvvDMRGLPIMRE-TGAPVIFDATHsvqlpggqGGssgGQREFVPVLARAAVA 220
|
250 260
....*....|....*....|....*
gi 1533683560 290 SGADGMIVEIHPDPANAWSDGPQSL 314
Cdd:PRK05198 221 VGVAGLFIETHPDPDNALSDGPNML 245
|
|
| DAHP_snth_FXD |
pfam18152 |
DAHP synthase ferredoxin-like domain; This domain is found in ... |
1-66 |
1.68e-24 |
|
DAHP synthase ferredoxin-like domain; This domain is found in 3-Deoxy-d-arabino-heptulosonate-7-phosphate synthase (DAHPS) present in Thermotoga maritime. DAHPS catalyzes the first reaction of the aromatic biosynthetic pathway in bacteria, fungi, and plants, the condensation of PEP and E4P with the formation of DAHP. The domain is ferredoxin-like and is thought to play a critical role in feedback regulation of the enzyme.
Pssm-ID: 436312 [Multi-domain] Cd Length: 67 Bit Score: 94.47 E-value: 1.68e-24
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1533683560 1 MIVIMKKEATEEQIKKVVDHIEKEGFKVSIDQGTERVVIGLKGDTRSLQEGAFTRYEGVENAVRIL 66
Cdd:pfam18152 1 MIIVMKPGATEEEIDEVIERIESLGLKVHVSRGTERTVIGLIGDTSKLDAEQLEALPGVERVVRVS 66
|
|
| PLN03033 |
PLN03033 |
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional |
95-311 |
1.90e-22 |
|
2-dehydro-3-deoxyphosphooctonate aldolase; Provisional
Pssm-ID: 178601 Cd Length: 290 Bit Score: 95.31 E-value: 1.90e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 95 FVTMAGPCSIEGLDQIRECARMAKAGGAKILRGGAFKP------RTSPYAFQGLE-EEGLKYIRQAADEFGMKVITEVMD 167
Cdd:PLN03033 17 FFLLAGPNVIESEEHILRMAKHIKDISTKLGLPLVFKSsfdkanRTSSKSFRGPGmAEGLKILEKVKVAYDLPIVTDVHE 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 168 EGHIDMVAEYSDILQIGARNMQNFKLLSAVGKTGKPVGLKRGISGTINEWLNAAEYIAVEDKSPVIFIERGirTYETATR 247
Cdd:PLN03033 97 SSQCEAVGKVADIIQIPAFLCRQTDLLVAAAKTGKIINIKKGQFCAPSVMRNSAEKVRLAGNPNVMVCERG--TMFGYND 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 248 NTFDLSAVPLMKKlTHFPVIVDPSHGT----------------GIWELVPPMARAGVASGADGMIVEIHPDPANAWSDGP 311
Cdd:PLN03033 175 LIVDPRNLEWMRE-ANCPVVADITHSLqqpagkkldgggvasgGLRELIPCIARTAVAVGVDGIFMEVHDDPLSAPVDGP 253
|
|
| PRK12457 |
PRK12457 |
3-deoxy-8-phosphooctulonate synthase; |
86-314 |
4.41e-18 |
|
3-deoxy-8-phosphooctulonate synthase;
Pssm-ID: 237105 Cd Length: 281 Bit Score: 82.87 E-value: 4.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 86 DGVKIG-DGSFVTMAGPCSIEGLDQIRECARMAKAGGAKILRGGAFKP------RTSPYAFQGLE-EEGLKYIRQAADEF 157
Cdd:PRK12457 7 PGITVGnDLPFVLFGGINVLESLDFTLDVCGEYVEVTRKLGIPFVFKAsfdkanRSSIHSYRGVGlDEGLRIFEEVKARF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 158 GMKVITEVMDEGHIDMVAEYSDILQIGARNMQNFKLLSAVGKTGKPVGLKRgisgtiNEWLNAAEYIAVEDK------SP 231
Cdd:PRK12457 87 GVPVITDVHEVEQAAPVAEVADVLQVPAFLARQTDLVVAIAKTGKPVNIKK------PQFMSPTQMKHVVSKcreagnDR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 232 VIFIERGIR-TYETAtrnTFDLSAVPLMKKLT-HFPVIVDPSHGT-----------GIWELVPPMARAGVASGADGMIVE 298
Cdd:PRK12457 161 VILCERGSSfGYDNL---VVDMLGFRQMKRTTgDLPVIFDVTHSLqcrdplgaasgGRRRQVLDLARAGMAVGLAGLFLE 237
|
250
....*....|....*.
gi 1533683560 299 IHPDPANAWSDGPQSL 314
Cdd:PRK12457 238 AHPDPDRARCDGPSAL 253
|
|
| IGPS |
cd00331 |
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ... |
142-193 |
6.42e-03 |
|
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.
Pssm-ID: 238203 Cd Length: 217 Bit Score: 37.44 E-value: 6.42e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1533683560 142 LEEEGLKYIRQAADEFGMKVITEVMDEGHIDMVAEYS-DILQIGARNMQNFKL 193
Cdd:cd00331 105 LDDEQLKELYELARELGMEVLVEVHDEEELERALALGaKIIGINNRDLKTFEV 157
|
|
| YcjR |
COG1082 |
Sugar phosphate isomerase/epimerase [Carbohydrate transport and metabolism]; |
105-182 |
6.48e-03 |
|
Sugar phosphate isomerase/epimerase [Carbohydrate transport and metabolism];
Pssm-ID: 440699 [Multi-domain] Cd Length: 254 Bit Score: 37.68 E-value: 6.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533683560 105 EGLDQIRECARMAKAGGAKILRGGAFKPRTSPYAFQGLEE---EGLKYIRQAADEFGMKVITEVMDEGHIDMVAEYSDIL 181
Cdd:COG1082 75 AALERLKRAIDLAAELGAKVVVVHPGSPPPPDLPPEEAWDrlaERLRELAELAEEAGVTLALENHEGTFVNTPEEALRLL 154
|
.
gi 1533683560 182 Q 182
Cdd:COG1082 155 E 155
|
|
| |
