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Conserved domains on  [gi|1536387463|gb|RSO52608|]
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transcriptional repressor [Acinetobacter lactucae]

Protein Classification

Fur family transcriptional regulator( domain architecture ID 10002362)

Fur (ferric uptake regulator) family transcriptional regulator such as metal ion uptake regulator proteins, which are responsible for controlling the intracellular concentration of iron in many bacteria

CATH:  3.30.1490.190|1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677|GO:0046872
PubMed:  17216355|24106689

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
1-130 1.91e-19

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


:

Pssm-ID: 440498  Cd Length: 140  Bit Score: 78.07  E-value: 1.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1536387463   1 MDYHQELIENGLSATPSRVAIFRFLHENDKGITAEEIYLLSQKKNLKISLATTYRTLAELEHRKLIKRVVLGkSNRGIYR 80
Cdd:COG0735     5 EEAEELLREAGLRLTPQRLAILELLLESDRHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFG-GGKARYE 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1536387463  81 LATNKISLNLINTKTGKSHPFEyDEKVEELLESLLKNIDEKALNIEVNVY 130
Cdd:COG0735    84 LNEGDHHHHLICTKCGKVIELD-DDEIEELLEELAEPHGFEIESHELEIY 132
 
Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
1-130 1.91e-19

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 78.07  E-value: 1.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1536387463   1 MDYHQELIENGLSATPSRVAIFRFLHENDKGITAEEIYLLSQKKNLKISLATTYRTLAELEHRKLIKRVVLGkSNRGIYR 80
Cdd:COG0735     5 EEAEELLREAGLRLTPQRLAILELLLESDRHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFG-GGKARYE 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1536387463  81 LATNKISLNLINTKTGKSHPFEyDEKVEELLESLLKNIDEKALNIEVNVY 130
Cdd:COG0735    84 LNEGDHHHHLICTKCGKVIELD-DDEIEELLEELAEPHGFEIESHELEIY 132
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 16-130 9.94e-16

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 67.99  E-value: 9.94e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1536387463  16 PSRVAIFRFLHENDKGITAEEIYLLSQKKNLKISLATTYRTLAELEHRKLIKRVVLGKSNRgIYRLATNKISLNLINTKT 95
Cdd:cd07153     1 PQRLAILEVLLESDGHLTAEEIYERLRKKGPSISLATVYRTLELLEEAGLVREIELGDGKA-RYELNTDEHHHHLICTKC 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1536387463  96 GKSHPFEyDEKVEELLESLLKNIDEKALNIEVNVY 130
Cdd:cd07153    80 GKVIDFE-DCPLEELLEELAAKTGFKITSHRLELY 113
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 9-130 3.62e-15

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


Pssm-ID: 426280  Cd Length: 121  Bit Score: 66.50  E-value: 3.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1536387463   9 ENGLSATPSRVAIFRFLHENDKG-ITAEEIYLLSQKKNLKISLATTYRTLAELEHRKLIKRVVLGkSNRGIYRLATNKIS 87
Cdd:pfam01475   1 EAGLKLTPQRLKILEVLQKSDKEhLSAEEIYKELREEDPNISLATVYRTLNLLEEAGLVKRLEFD-GGESRFELNTGHHH 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1536387463  88 LNLINTKTGKSHPFEYDEkVEELLESLLKNIDEKALNIEVNVY 130
Cdd:pfam01475  80 DHLICEDCGKVIEFKDDE-IEKRQEEIAKKHGFKLVSHRLELY 121
fur PRK09462
ferric uptake regulator; Provisional
 1-109 2.54e-03

ferric uptake regulator; Provisional


Pssm-ID: 236527  Cd Length: 148  Bit Score: 35.86  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1536387463   1 MDYHQELIENGLSATPSRVAIFRFLHEND-KGITAEEIY--LLSQKKnlKISLATTYRTLAELEHRKLIKRVVL--GKSn 75
Cdd:PRK09462    2 TDNNTALKKAGLKVTLPRLKILEVLQEPDnHHVSAEDLYkrLIDMGE--EIGLATVYRVLNQFDDAGIVTRHNFegGKS- 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1536387463  76 rgIYRLATNKISLNLINTKTGKSHPFEyDEKVEE 109
Cdd:PRK09462   79 --VFELTQQHHHDHLICLDCGKVIEFS-DDSIEA 109
 
Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
1-130 1.91e-19

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 78.07  E-value: 1.91e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1536387463   1 MDYHQELIENGLSATPSRVAIFRFLHENDKGITAEEIYLLSQKKNLKISLATTYRTLAELEHRKLIKRVVLGkSNRGIYR 80
Cdd:COG0735     5 EEAEELLREAGLRLTPQRLAILELLLESDRHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFG-GGKARYE 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1536387463  81 LATNKISLNLINTKTGKSHPFEyDEKVEELLESLLKNIDEKALNIEVNVY 130
Cdd:COG0735    84 LNEGDHHHHLICTKCGKVIELD-DDEIEELLEELAEPHGFEIESHELEIY 132
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 16-130 9.94e-16

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 67.99  E-value: 9.94e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1536387463  16 PSRVAIFRFLHENDKGITAEEIYLLSQKKNLKISLATTYRTLAELEHRKLIKRVVLGKSNRgIYRLATNKISLNLINTKT 95
Cdd:cd07153     1 PQRLAILEVLLESDGHLTAEEIYERLRKKGPSISLATVYRTLELLEEAGLVREIELGDGKA-RYELNTDEHHHHLICTKC 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1536387463  96 GKSHPFEyDEKVEELLESLLKNIDEKALNIEVNVY 130
Cdd:cd07153    80 GKVIDFE-DCPLEELLEELAAKTGFKITSHRLELY 113
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 9-130 3.62e-15

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


Pssm-ID: 426280  Cd Length: 121  Bit Score: 66.50  E-value: 3.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1536387463   9 ENGLSATPSRVAIFRFLHENDKG-ITAEEIYLLSQKKNLKISLATTYRTLAELEHRKLIKRVVLGkSNRGIYRLATNKIS 87
Cdd:pfam01475   1 EAGLKLTPQRLKILEVLQKSDKEhLSAEEIYKELREEDPNISLATVYRTLNLLEEAGLVKRLEFD-GGESRFELNTGHHH 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1536387463  88 LNLINTKTGKSHPFEYDEkVEELLESLLKNIDEKALNIEVNVY 130
Cdd:pfam01475  80 DHLICEDCGKVIEFKDDE-IEKRQEEIAKKHGFKLVSHRLELY 121
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 20-76 1.49e-04

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 37.97  E-value: 1.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1536387463  20 AIFRFLHENDKGITAEEIyllsqKKNLKISLATTYRTLAELEHRKLIKRVVLGKSNR 76
Cdd:COG2512    19 RVLELLRENGGRMTQSEI-----VKETGWSKSKVSRLLSRLEERGLIEKERVGRENV 70
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 14-73 1.44e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 34.82  E-value: 1.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1536387463  14 ATPSRVAIFRFLHENDkGITAEEIyllsqKKNLKISLATTYRTLAELEHRKLIKRVVLGK 73
Cdd:pfam12840   8 ADPTRLRILRALVGDE-PLTASEL-----ARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
fur PRK09462
ferric uptake regulator; Provisional
 1-109 2.54e-03

ferric uptake regulator; Provisional


Pssm-ID: 236527  Cd Length: 148  Bit Score: 35.86  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1536387463   1 MDYHQELIENGLSATPSRVAIFRFLHEND-KGITAEEIY--LLSQKKnlKISLATTYRTLAELEHRKLIKRVVL--GKSn 75
Cdd:PRK09462    2 TDNNTALKKAGLKVTLPRLKILEVLQEPDnHHVSAEDLYkrLIDMGE--EIGLATVYRVLNQFDDAGIVTRHNFegGKS- 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1536387463  76 rgIYRLATNKISLNLINTKTGKSHPFEyDEKVEE 109
Cdd:PRK09462   79 --VFELTQQHHHDHLICLDCGKVIEFS-DDSIEA 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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