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Conserved domains on  [gi|1541475619|gb|RTM20994|]
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addiction module killer protein [Enterobacter bugandensis]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 10007661)

type II toxin-antitoxin system RelE/ParE family toxin similar to Haemophilus influenzae protein HI_1419

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3657 COG3657
Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];
8-108 2.40e-40

Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];


:

Pssm-ID: 442874  Cd Length: 103  Bit Score: 129.50  E-value: 2.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541475619   8 ERYRTRDGKVPFEEWVARMnrRDPDTVFRILMRINRAIKRNFGDYRYLREGVWEMRVDSGPGYRIYFAVKNRQVLLLLIG 87
Cdd:COG3657     1 REYYTIDGTEPFDEWLASL--KDRRARARILARLDRLELGNFGDVKPVGEGVSELRIDFGPGYRVYYAQRGDVLVLLLCG 78

                          90       100
                  ....*....|....*....|.
gi 1541475619  88 GDKKSQKADIKLAIDYWKDHQ 108
Cdd:COG3657    79 GDKSTQQKDIKKAKELAKEYK 99
 
Name Accession Description Interval E-value
COG3657 COG3657
Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];
8-108 2.40e-40

Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];


Pssm-ID: 442874  Cd Length: 103  Bit Score: 129.50  E-value: 2.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541475619   8 ERYRTRDGKVPFEEWVARMnrRDPDTVFRILMRINRAIKRNFGDYRYLREGVWEMRVDSGPGYRIYFAVKNRQVLLLLIG 87
Cdd:COG3657     1 REYYTIDGTEPFDEWLASL--KDRRARARILARLDRLELGNFGDVKPVGEGVSELRIDFGPGYRVYYAQRGDVLVLLLCG 78

                          90       100
                  ....*....|....*....|.
gi 1541475619  88 GDKKSQKADIKLAIDYWKDHQ 108
Cdd:COG3657    79 GDKSTQQKDIKKAKELAKEYK 99
upstrm_HI1419 TIGR02683
putative addiction module killer protein; Members of this strictly bacterial protein family ...
 14-107 6.64e-31

putative addiction module killer protein; Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the upstream member of a gene pair, where the downstream member is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, often are located with prophage regions, but also in both integrated plasmid regions and near housekeeping genes. Analysis suggests that the gene pair may serve as an addiction module.


Pssm-ID: 162974  Cd Length: 95  Bit Score: 105.36  E-value: 6.64e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541475619  14 DGKVPFEEWVARMnrRDPDTVFRILMRINRAIKRNFGDYRYLREGVWEMRVDSGPGYRIYFAVKNRQVLLLLIGGDKKSQ 93
Cdd:TIGR02683   4 DRTDTFDKWLDGL--KDPRAKARILARIDRLALGNFGDVKPVGEGVSELRIDFGPGYRVYFTQRGKVIILLLCGGDKSTQ 81

                          90
                  ....*....|....
gi 1541475619  94 KADIKLAIDYWKDH 107
Cdd:TIGR02683  82 QKDIKRAKELAKDL 95
Gp49 pfam05973
Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial ...
 53-105 6.68e-07

Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.


Pssm-ID: 461791  Cd Length: 90  Bit Score: 43.72  E-value: 6.68e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1541475619  53 RYLREGVWEMRVDSGPG-YRIYFAVKNRQVLLLLIGGDKKSQK---ADIKLAIDYWK 105
Cdd:pfam05973  34 KKLGGGLWELRVRDAGGiYRVLYAFDPGRAVYVLHAFQKKTQKtpkKEIDLAERRLK 90
 
Name Accession Description Interval E-value
COG3657 COG3657
Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];
8-108 2.40e-40

Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];


Pssm-ID: 442874  Cd Length: 103  Bit Score: 129.50  E-value: 2.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541475619   8 ERYRTRDGKVPFEEWVARMnrRDPDTVFRILMRINRAIKRNFGDYRYLREGVWEMRVDSGPGYRIYFAVKNRQVLLLLIG 87
Cdd:COG3657     1 REYYTIDGTEPFDEWLASL--KDRRARARILARLDRLELGNFGDVKPVGEGVSELRIDFGPGYRVYYAQRGDVLVLLLCG 78

                          90       100
                  ....*....|....*....|.
gi 1541475619  88 GDKKSQKADIKLAIDYWKDHQ 108
Cdd:COG3657    79 GDKSTQQKDIKKAKELAKEYK 99
upstrm_HI1419 TIGR02683
putative addiction module killer protein; Members of this strictly bacterial protein family ...
 14-107 6.64e-31

putative addiction module killer protein; Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the upstream member of a gene pair, where the downstream member is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, often are located with prophage regions, but also in both integrated plasmid regions and near housekeeping genes. Analysis suggests that the gene pair may serve as an addiction module.


Pssm-ID: 162974  Cd Length: 95  Bit Score: 105.36  E-value: 6.64e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541475619  14 DGKVPFEEWVARMnrRDPDTVFRILMRINRAIKRNFGDYRYLREGVWEMRVDSGPGYRIYFAVKNRQVLLLLIGGDKKSQ 93
Cdd:TIGR02683   4 DRTDTFDKWLDGL--KDPRAKARILARIDRLALGNFGDVKPVGEGVSELRIDFGPGYRVYFTQRGKVIILLLCGGDKSTQ 81

                          90
                  ....*....|....
gi 1541475619  94 KADIKLAIDYWKDH 107
Cdd:TIGR02683  82 QKDIKRAKELAKDL 95
Gp49 pfam05973
Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial ...
 53-105 6.68e-07

Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.


Pssm-ID: 461791  Cd Length: 90  Bit Score: 43.72  E-value: 6.68e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1541475619  53 RYLREGVWEMRVDSGPG-YRIYFAVKNRQVLLLLIGGDKKSQK---ADIKLAIDYWK 105
Cdd:pfam05973  34 KKLGGGLWELRVRDAGGiYRVLYAFDPGRAVYVLHAFQKKTQKtpkKEIDLAERRLK 90
COG4679 COG4679
Phage-related protein [Mobilome: prophages, transposons];
16-106 1.06e-06

Phage-related protein [Mobilome: prophages, transposons];


Pssm-ID: 443715  Cd Length: 113  Bit Score: 43.69  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541475619  16 KVPFEEWVARMNRRDPDTVFRILMRINRAIKRNFGDY-RYLREGVWEMRVDSGPG-YRIYFAVKNRQVLLLLIGGDKKSQ 93
Cdd:COG4679    11 KEPVLDFLLALPAKVRAKIGRALDLLQEGGPDLGKPLtKGLGDGLFELRIKGGSGiYRVLYFAKFGDAVVVLHGFQKKTQ 90

                          90
                  ....*....|....*.
gi 1541475619  94 K---ADIKLAIDYWKD 106
Cdd:COG4679    91 KtpkKEIELARKRLKE 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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