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Conserved domains on  [gi|1541485753|gb|RTM30902|]
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type III secretion system invasion protein IagB [Enterobacter bugandensis]

Protein Classification

lysozyme family protein( domain architecture ID 63)

lysozyme family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lyz-like super family cl00222
lysozyme-like domains; This family contains several members, including soluble lytic ...
 1-146 3.52e-89

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


The actual alignment was detected with superfamily member PRK15328:

Pssm-ID: 469668 [Multi-domain]  Cd Length: 160  Bit Score: 256.33  E-value: 3.52e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753   1 MKKFILLLLIIS--HGALANCWNNAAHYYHVDPYLLYAIANVESGMNPYAVGQNHDGTRDVGLMQINSSHFTELERKGID 78
Cdd:PRK15328    1 MHYFFIIVIWLLsiNTAWADCWLQAEKMFNIESELLYAIAQQESAMKPGAIGHNRDGSTDLGLMQINSFHMKRLKKMGIS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1541485753  79 EYRLMAEPCTSIMVGASILSNMIKVYGYNWEAVGAYNAGLKRENYPQRMMYAHKVWKKYQELKLAARY 146
Cdd:PRK15328   81 EKQLLQDPCISVIVGASILSDMMKIYGYSWEAVGAYNAGTSPKRSDIRKRYAKKIWENYRKLKGMSAE 148
 
Name Accession Description Interval E-value
PRK15328 PRK15328
type III secretion system invasion protein IagB;
1-146 3.52e-89

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 256.33  E-value: 3.52e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753   1 MKKFILLLLIIS--HGALANCWNNAAHYYHVDPYLLYAIANVESGMNPYAVGQNHDGTRDVGLMQINSSHFTELERKGID 78
Cdd:PRK15328    1 MHYFFIIVIWLLsiNTAWADCWLQAEKMFNIESELLYAIAQQESAMKPGAIGHNRDGSTDLGLMQINSFHMKRLKKMGIS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1541485753  79 EYRLMAEPCTSIMVGASILSNMIKVYGYNWEAVGAYNAGLKRENYPQRMMYAHKVWKKYQELKLAARY 146
Cdd:PRK15328   81 EKQLLQDPCISVIVGASILSDMMKIYGYSWEAVGAYNAGTSPKRSDIRKRYAKKIWENYRKLKGMSAE 148
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 27-138 2.72e-50

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 156.15  E-value: 2.72e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  27 YHVDPYLLYAIANVESGMNPYAVGQNHDGTRDVGLMQINSSHFTELERKGIDEYRLMAEPCTSIMVGASILSNMIKVYGY 106
Cdd:cd13400     1 YGVPPRLLRAIAKVESGFNPNAINRNKNGSYDIGLMQINSIWLPELARYGITREELLNDPCTNIYVGAWILARNIKRYGN 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1541485753 107 NWEAVGAYNAGlkreNYPQRMMYAHKVWKKYQ 138
Cdd:cd13400    81 TWKAVGAYNSG----TPKKNDKYARKVYRIYR 108
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 20-118 1.88e-27

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 98.15  E-value: 1.88e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  20 WNNAAHYYHVDPYLLYAIANVESGMNPYAVGqnhdGTRDVGLMQINSSHFTELERKGIDEYRLMAEPCTSIMVGASILSN 99
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVS----KSGAVGLMQIMPSTAKRLGLRVNPGVDDLFDPEKNIKAGTKYLKE 76

                          90       100
                  ....*....|....*....|
gi 1541485753 100 MIKVYGYNW-EAVGAYNAGL 118
Cdd:pfam01464  77 LYKQYGGDLwLALAAYNAGP 96
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 23-120 1.34e-12

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 62.71  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  23 AAHYYHVDPYLLYAIANVESGMNPYAVGqnHDGTRdvGLMQINSS--HFTELERKGIDEYRLMAEPCTSIMVGASILSNM 100
Cdd:COG0741   110 AAKKYGVDPALVLALIRQESAFNPNAVS--PAGAR--GLMQLMPAtaRRLGLKLGLGPSPDDLFDPETNIRAGAAYLREL 185

                          90       100
                  ....*....|....*....|.
gi 1541485753 101 IKVYGYNWE-AVGAYNAGLKR 120
Cdd:COG0741   186 LDRFDGDLVlALAAYNAGPGR 206
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
37-66 3.18e-03

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 35.34  E-value: 3.18e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1541485753   37 IANVESGMNPYAVGQNHDGTRDVGLMQINS 66
Cdd:smart00263  31 LAFHESGYNTQATNYNNGGSTDYGIFQINS 60
 
Name Accession Description Interval E-value
PRK15328 PRK15328
type III secretion system invasion protein IagB;
1-146 3.52e-89

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 256.33  E-value: 3.52e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753   1 MKKFILLLLIIS--HGALANCWNNAAHYYHVDPYLLYAIANVESGMNPYAVGQNHDGTRDVGLMQINSSHFTELERKGID 78
Cdd:PRK15328    1 MHYFFIIVIWLLsiNTAWADCWLQAEKMFNIESELLYAIAQQESAMKPGAIGHNRDGSTDLGLMQINSFHMKRLKKMGIS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1541485753  79 EYRLMAEPCTSIMVGASILSNMIKVYGYNWEAVGAYNAGLKRENYPQRMMYAHKVWKKYQELKLAARY 146
Cdd:PRK15328   81 EKQLLQDPCISVIVGASILSDMMKIYGYSWEAVGAYNAGTSPKRSDIRKRYAKKIWENYRKLKGMSAE 148
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 27-138 2.72e-50

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 156.15  E-value: 2.72e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  27 YHVDPYLLYAIANVESGMNPYAVGQNHDGTRDVGLMQINSSHFTELERKGIDEYRLMAEPCTSIMVGASILSNMIKVYGY 106
Cdd:cd13400     1 YGVPPRLLRAIAKVESGFNPNAINRNKNGSYDIGLMQINSIWLPELARYGITREELLNDPCTNIYVGAWILARNIKRYGN 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1541485753 107 NWEAVGAYNAGlkreNYPQRMMYAHKVWKKYQ 138
Cdd:cd13400    81 TWKAVGAYNSG----TPKKNDKYARKVYRIYR 108
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 20-118 1.88e-27

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 98.15  E-value: 1.88e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  20 WNNAAHYYHVDPYLLYAIANVESGMNPYAVGqnhdGTRDVGLMQINSSHFTELERKGIDEYRLMAEPCTSIMVGASILSN 99
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVS----KSGAVGLMQIMPSTAKRLGLRVNPGVDDLFDPEKNIKAGTKYLKE 76

                          90       100
                  ....*....|....*....|
gi 1541485753 100 MIKVYGYNW-EAVGAYNAGL 118
Cdd:pfam01464  77 LYKQYGGDLwLALAAYNAGP 96
PRK13722 PRK13722
lytic transglycosylase; Provisional
 1-141 1.16e-23

lytic transglycosylase; Provisional


Pssm-ID: 184274 [Multi-domain]  Cd Length: 169  Bit Score: 90.53  E-value: 1.16e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753   1 MKKFIL---LLLIISHGALANCWNNAAHYYHVDPYLLYAIANVESGMNPYAVGQNHDGTRDVGLMQINSSHFTELERKGI 77
Cdd:PRK13722    1 MKKWMLaicLMFINEICHATDCFDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGI 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1541485753  78 DEYRLMAEPCTSIMVGASILSNMIKVYGYNWEAVGAYNAGLK---RENyPQRMMYAHKVWKKYQELK 141
Cdd:PRK13722   81 KPEHLTTDPCMNIYTGAYYLAIAFKKWGVSWEAVGAYNAGFRkteRQN-QRRLAYASEVYRIYTGIK 146
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 31-138 2.09e-13

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 62.23  E-value: 2.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  31 PYLLYAIANVESGMNPYAVgqNHDGTRdvGLMQINSSHFTELERKGIDEYRlmaEPCTSIMVGASILSNMIKVYGYNWE- 109
Cdd:cd00254     1 PALVLAVIRVESGFNPRAV--SPAGAR--GLMQLMPGTARDLGRRGVDDLF---DPEENIRAGARYLRELLDRFGGDLEl 73

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1541485753 110 AVGAYNAG-------LKREN--YPQRMMYAHKVWKKYQ 138
Cdd:cd00254    74 ALAAYNAGpgavdrwGGGEVppYKETRNYVQRVLAYYQ 111
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 23-117 3.81e-13

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 62.53  E-value: 3.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  23 AAHYYHVDPYLLYAIANVESGMNPYAVGqnHDGTRdvGLMQINSSHFTEL-ERKGIDEYR--LMAEPCTSIMVGASILSN 99
Cdd:cd16896    11 YAKEYGVDPLLVAAVIKVESNFNPNAVS--SKGAI--GLMQIMPETAEWIaEKLGLEDFSedDLYDPETNIRLGTWYLSY 86

                          90
                  ....*....|....*....
gi 1541485753 100 MIKVYGYNWE-AVGAYNAG 117
Cdd:cd16896    87 LLKEFDGNLVlALAAYNAG 105
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 23-120 1.34e-12

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 62.71  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  23 AAHYYHVDPYLLYAIANVESGMNPYAVGqnHDGTRdvGLMQINSS--HFTELERKGIDEYRLMAEPCTSIMVGASILSNM 100
Cdd:COG0741   110 AAKKYGVDPALVLALIRQESAFNPNAVS--PAGAR--GLMQLMPAtaRRLGLKLGLGPSPDDLFDPETNIRAGAAYLREL 185

                          90       100
                  ....*....|....*....|.
gi 1541485753 101 IKVYGYNWE-AVGAYNAGLKR 120
Cdd:COG0741   186 LDRFDGDLVlALAAYNAGPGR 206
LT_VirB1-like cd16892
VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up ...
 29-98 1.01e-11

VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up type IV secretion systems (T4SS). T4SS are macromolecular assemblies generally composed of VirB1-11 and VirD4 proteins, and are used by bacteria to transport material across their membranes. VirB1 acts as a lytic transglycosylase (LT), and is important with respect to piercing the peptidoglycan layer in the periplasm. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381613 [Multi-domain]  Cd Length: 143  Bit Score: 58.71  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  29 VDPYLLYAIANVESGMNPYAVGQNHDGTR-----------------------DVGLMQINSSHFtelERKGIDeYRLMAE 85
Cdd:cd16892     9 VHPETLAAIVQVESGGNPYAIGVNGGKLSrqpktkaeaiatarqliaaghnfDVGLGQINSRNL---ARLGLT-VEDVFD 84

                          90
                  ....*....|...
gi 1541485753  86 PCTSIMVGASILS 98
Cdd:cd16892    85 PCTNLKAGATILT 97
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 21-120 3.88e-10

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 54.40  E-value: 3.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  21 NNAAHYYHVDPYLLYAIANVESGMNPYAVGqnHDGtrDVGLMQI---NSSHFTELERKGIDEYRLMAEPCTSIMVGASIL 97
Cdd:cd13401    11 ERAAKKNGLDPALVYAIIRQESAFDPDAVS--PAG--ALGLMQLmpaTAKDVAKKLGLPYYSPRDLFDPEYNIRLGSAYL 86

                          90       100
                  ....*....|....*....|....
gi 1541485753  98 SNMIKVYGYNWE-AVGAYNAGLKR 120
Cdd:cd13401    87 AELLDRFDGNPVlALAAYNAGPGR 110
PRK13864 PRK13864
type IV secretion system lytic transglycosylase VirB1; Provisional
 29-97 1.86e-07

type IV secretion system lytic transglycosylase VirB1; Provisional


Pssm-ID: 237534  Cd Length: 245  Bit Score: 48.32  E-value: 1.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  29 VDPYLLYAIANVESGMNPYAV----------GQNH-DGTR------------DVGLMQINSSHFTELerkGIDEyRLMAE 85
Cdd:PRK13864   41 VAPSTLAAIAKVESRFDPLAVhdnttgetlhWQNHaQATQsvrhrlearhslDVGLMQINSKNFSVL---GLTP-DGALQ 116

                          90
                  ....*....|..
gi 1541485753  86 PCTSIMVGASIL 97
Cdd:PRK13864  117 PCTSLSAAANLL 128
PRK13888 PRK13888
conjugal transfer protein TrbN; Provisional
 19-77 2.81e-07

conjugal transfer protein TrbN; Provisional


Pssm-ID: 237545  Cd Length: 206  Bit Score: 47.51  E-value: 2.81e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1541485753  19 CWNNAAHYYHVDPYLLYAIANVESGmNPyavGQ---NHDGTRDVGLMQINSSHFTELERKGI 77
Cdd:PRK13888   17 CSISAAVKYEVPANIVLAVAEKEGG-KP---GQwvrNTNGTHDVGPMQFNTAYLGDLARYGI 74
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
23-130 3.00e-06

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 44.96  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  23 AAHYYHVDPYLLYAIANVESGMNPYAVGQNHdgtrDVGLMQINSShfteleRKGIDEYRLM---AEPCTS--------IM 91
Cdd:PRK15470   46 AGAAWGVDPQLITAIIAIESGGNPNAVSKSN----AIGLMQLKAS------TSGRDVYRRMgwsGEPTTSelknpernIS 115

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1541485753  92 VGASILSNMikvygynweavgaYNAGLKRENYPQRMMYA 130
Cdd:PRK15470  116 MGAAYLNIL-------------ETGPLAGIEDPKVLQYA 141
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 21-64 5.97e-06

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 43.32  E-value: 5.97e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1541485753  21 NNAAHYYHVDPYLLYAIANVESGMNPYAVGQnhdgTRDVGLMQI 64
Cdd:cd16893     4 EKYAKKYGVDPALILAIIETESSFNPYAVSH----SPAYGLMQI 43
SLT_3 pfam18896
Lysozyme like domain; This entry represents a lysozyme like domain found in candidate phyla ...
 36-66 2.44e-04

Lysozyme like domain; This entry represents a lysozyme like domain found in candidate phyla radiation bacteria. The domain contains several conserved cysteine and histidine residues suggesting that it may bind to zinc.


Pssm-ID: 436815 [Multi-domain]  Cd Length: 89  Bit Score: 37.77  E-value: 2.44e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1541485753  36 AIANVESGMNPYAVG--QNHDGTRDVGLMQINS 66
Cdd:pfam18896  19 AVAMAESGGDPSAVGdlANTKGSPSRGLWQINS 51
LYZ_C cd16897
C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). ...
 38-68 3.25e-04

C-type lysozyme; C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase). In humans, lysozyme is found in a wide variety of tissue types and body fluids. It has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins. This family also includes digestive stomach lysozyme, which allow ruminants to digest bacteria in the foregut. The mammalian enzyme is related to lysozyme found hen egg-whites and related species.


Pssm-ID: 340383  Cd Length: 126  Bit Score: 38.02  E-value: 3.25e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1541485753  38 ANVESGMNPYAVGQNHDGTRDVGLMQINSSH 68
Cdd:cd16897    32 AYYESGFNTRATNENPDGSTDYGIFQINSRY 62
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 23-120 4.21e-04

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 39.27  E-value: 4.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  23 AAHYYHVDPYLLYAIANVESGMNPYAVGqnHDGTRdvGLMQINSSHFTELerkGIDEyRLMAEpcTSIMVGASILSNMIK 102
Cdd:COG4623   271 YAEEYGLDWRLLAALAYQESHWNPRARS--PTGAR--GLMQLMPATAKEL---GVDD-RLDPE--QSIRAGAKYLRWLYD 340

                          90       100
                  ....*....|....*....|....*
gi 1541485753 103 VYGYN-------WEAVGAYNAGLKR 120
Cdd:COG4623   341 RFPEAidepdrwWFALAAYNAGPGH 365
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
23-64 7.08e-04

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 38.49  E-value: 7.08e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1541485753  23 AAHYYHVDPYLLYAIANVESGMNPYAVgqnhDGTRDVGLMQI 64
Cdd:PRK11671  199 ASRKYGVDESLILAIMQTESSFNPYAV----SRSDALGLMQV 236
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 23-118 9.87e-04

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 37.13  E-value: 9.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  23 AAHYYHVDPYLLYAIANVESGMNPYAVGqnHDGTRdvGLMQINSShfTeLERKGIDEYRlmaEPCTSIMVGASILSNMIK 102
Cdd:cd13403     4 YAEKYGFDWRLLAAQAYQESRFNPNARS--PAGAR--GLMQLMPS--T-ARELGVNDRL---DPEQNIHAGAKYLRYLRD 73

                          90       100
                  ....*....|....*....|...
gi 1541485753 103 VYGY-------NWEAVGAYNAGL 118
Cdd:cd13403    74 RFPPdidepdrLKFALAAYNAGP 96
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 37-66 3.11e-03

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 35.28  E-value: 3.11e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1541485753  37 IANVESGMNPYAVGQ-NHDGTRDVGLMQINS 66
Cdd:cd16899    28 LAEHESSFNTTAVGGpNSDGSGDYGLFQIND 58
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
37-66 3.18e-03

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 35.34  E-value: 3.18e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1541485753   37 IANVESGMNPYAVGQNHDGTRDVGLMQINS 66
Cdd:smart00263  31 LAFHESGYNTQATNYNNGGSTDYGIFQINS 60
Phage_lysozyme2 pfam18013
Phage tail lysozyme; This domain has a lysozyme like fold. It is found in the tail protein of ...
 36-137 5.20e-03

Phage tail lysozyme; This domain has a lysozyme like fold. It is found in the tail protein of various phages probably giving them the ability to degrade the host cell wall peptidoglycan layer.


Pssm-ID: 465617  Cd Length: 139  Bit Score: 34.97  E-value: 5.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541485753  36 AIANVESGMNPYAVGQNHDGTRDVGLMQINSSHFTELER----KGIDEY-------RLMAEPCTS-------IMVGASIL 97
Cdd:pfam18013  25 GNMQRESGFNPGAVEDEGGGGGGYGLVQWTGGRKTALINfakaKGKSWSdldaqldFLDKELNNStykaakkKLKSATSP 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1541485753  98 SNMIKVYGYNWEAVGAYNAglkreNYPQRMMYAHKVWKKY 137
Cdd:pfam18013 105 EEAAKAFLRYYERPGVKDA-----KLEERGAYAQKWYDKF 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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