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Conserved domains on  [gi|1541602072|gb|RTN44980|]
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PLP-dependent aminotransferase family protein [Enterobacter hormaechei]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 11439382)

pyridoxal phosphate (PLP)-dependent aminotransferase family protein may catalyze the reversible exchange of an amino group from one molecule with a keto group from another molecule

CATH:  3.40.640.10
Gene Ontology:  GO:0030170
PubMed:  17109392
SCOP:  4000670

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 12-481 3.23e-165

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


:

Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 475.09  E-value: 3.23e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072  12 LHAALKKRGTETLQRALYLALREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGYLL-RSRQGTRVgqfA 90
Cdd:COG1167     1 MLIRLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIEsRPGSGTFV---A 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072  91 PRtIARTLPDPDVRLTKRVARLPAPVPRDTPVMAFTPGTPAINYFPLPLWRRLYDRVLREEGSALLGYGDPAGEPSLRAA 170
Cdd:COG1167    78 AR-LPAPAPAPRAAAAVAAPALRRLLEAAPGVIDLGSGAPDPDLFPLAALRRALRRALRRLPPALLGYGDPQGLPELREA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 171 IARHLAlSRGIDCDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAFVKTGLAMTGIPVDDEGMC---WEG 247
Cdd:COG1167   157 IARYLA-RRGVPASPDQILITSGAQQALDLALRALLRPGDTVAVESPTYPGALAALRAAGLRLVPVPVDEDGLDldaLEA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 248 LCA-PSPTLIFTSPSHQFPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYTGEPVPAMLGMVNNAPVVYLGTFSKT 326
Cdd:COG1167   236 ALRrHRPRAVYVTPSHQNPTGATMSLERRRALLELARRHGVPIIEDDYDSELRYDGRPPPPLAALDAPGRVIYIGSFSKT 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 327 LFPSLRMGFMVLPPALAKAARPAIGSLLRGGHRAEQRTLALFIEEGHYARHLAAMRRLYRKRYRQLREVLSAELHTPHRV 406
Cdd:COG1167   316 LAPGLRLGYLVAPGRLIERLARLKRATDLGTSPLTQLALAEFLESGHYDRHLRRLRREYRARRDLLLAALARHLPDGLRV 395

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1541602072 407 LAGEGGMHLALAI-DGIDDQRLVEQARAFQLAPAALSGYYLeTKQGQTGLVLGYGNTSASQFAPGIRRLQALITQQ 481
Cdd:COG1167   396 TGPPGGLHLWLELpEGVDAEALAAAALARGILVAPGSAFSA-DGPPRNGLRLGFGAPSEEELEEALRRLAELLREL 470
 
Name Accession Description Interval E-value
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 12-481 3.23e-165

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 475.09  E-value: 3.23e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072  12 LHAALKKRGTETLQRALYLALREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGYLL-RSRQGTRVgqfA 90
Cdd:COG1167     1 MLIRLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIEsRPGSGTFV---A 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072  91 PRtIARTLPDPDVRLTKRVARLPAPVPRDTPVMAFTPGTPAINYFPLPLWRRLYDRVLREEGSALLGYGDPAGEPSLRAA 170
Cdd:COG1167    78 AR-LPAPAPAPRAAAAVAAPALRRLLEAAPGVIDLGSGAPDPDLFPLAALRRALRRALRRLPPALLGYGDPQGLPELREA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 171 IARHLAlSRGIDCDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAFVKTGLAMTGIPVDDEGMC---WEG 247
Cdd:COG1167   157 IARYLA-RRGVPASPDQILITSGAQQALDLALRALLRPGDTVAVESPTYPGALAALRAAGLRLVPVPVDEDGLDldaLEA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 248 LCA-PSPTLIFTSPSHQFPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYTGEPVPAMLGMVNNAPVVYLGTFSKT 326
Cdd:COG1167   236 ALRrHRPRAVYVTPSHQNPTGATMSLERRRALLELARRHGVPIIEDDYDSELRYDGRPPPPLAALDAPGRVIYIGSFSKT 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 327 LFPSLRMGFMVLPPALAKAARPAIGSLLRGGHRAEQRTLALFIEEGHYARHLAAMRRLYRKRYRQLREVLSAELHTPHRV 406
Cdd:COG1167   316 LAPGLRLGYLVAPGRLIERLARLKRATDLGTSPLTQLALAEFLESGHYDRHLRRLRREYRARRDLLLAALARHLPDGLRV 395

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1541602072 407 LAGEGGMHLALAI-DGIDDQRLVEQARAFQLAPAALSGYYLeTKQGQTGLVLGYGNTSASQFAPGIRRLQALITQQ 481
Cdd:COG1167   396 TGPPGGLHLWLELpEGVDAEALAAAALARGILVAPGSAFSA-DGPPRNGLRLGFGAPSEEELEEALRRLAELLREL 470
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 125-431 5.71e-58

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 195.25  E-value: 5.71e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 125 FTPGTPAINYFPLPLWRRlydrVLREEGSALLGYGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALEGVNLCTML 204
Cdd:cd00609     3 LSIGEPDFPPPPEVLEAL----AAAALRAGLLGYYPDPGLPELREAIAEWLGRRGGVDVPPEEIVVTNGAQEALSLLLRA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 205 LSEPGDVAWVENPGYSGAKSAFVKTGLAMTGIPVDDEGMCWEGLC------APSPTLIFTSPsHQFPYGSVLSARRRLAL 278
Cdd:cd00609    79 LLNPGDEVLVPDPTYPGYEAAARLAGAEVVPVPLDEEGGFLLDLElleaakTPKTKLLYLNN-PNNPTGAVLSEEELEEL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 279 LELARQHNAWIIEDDYDSEFRYTGEPVPAMLGMVNNAPVVYLGTFSKTL-FPSLRMGFMVLPP-ALAKAARPAIGSLLRG 356
Cdd:cd00609   158 AELAKKHGILIISDEAYAELVYDGEPPPALALLDAYERVIVLRSFSKTFgLPGLRIGYLIAPPeELLERLKKLLPYTTSG 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1541602072 357 GHRAEQRTLALFIEEGHyaRHLAAMRRLYRKRYRQLREVLSAELhtPHRVLAGEGGMHLALAIDGIDDQRLVEQA 431
Cdd:cd00609   238 PSTLSQAAAAAALDDGE--EHLEELRERYRRRRDALLEALKELG--PLVVVKPSGGFFLWLDLPEGDDEEFLERL 308
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 32-437 2.69e-25

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 107.82  E-value: 2.69e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072  32 LREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGYLL-RSRQGTRV-GQFAPRTIARTlpDPDVRLTKRV 109
Cdd:PRK15481   14 IRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQsQGRNGTVIrGSPSPVALEGG--DPGTPLHDLA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 110 ARLPAP--VPRDTPVMAFTPGTPainyfplplwrRLydrvlreegsallgYGDPAGEPSLRAAIARHLALsrgiDCDAS- 186
Cdd:PRK15481   92 GGNPDPqrLPDLSRYFARLSRTP-----------RL--------------YGDAPVSPELHAWAARWLRD----DCPVAf 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 187 QIVITEGALEGVN--LCTMLLsePGDVAWVENPGYSGAKSAFVKTGLAMTGIPVDDEGMCWEG----LCAPSPTLIFTSP 260
Cdd:PRK15481  143 EIDLTSGAIDAIErlLCAHLL--PGDSVAVEDPCFLSSINMLRYAGFSASPVSVDAEGMQPEKleraLAQGARAVILTPR 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 261 SHQfPYGSVLSARRRLALLE-LARQHNAWIIEDDYdseFrytgepvpAMLGMVNNAPVVYLGT--------FSKTLFPSL 331
Cdd:PRK15481  221 AHN-PTGCSLSARRAAALRNlLARYPQVLVIIDDH---F--------ALLSSSPYHSVIPQTTqrwalirsVSKALGPDL 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 332 RMGFMVLPPALAKAARPAIGSllrGG----HRAEQRTLALFIEEGhYARHLAAMRRLYRKRYRQLREVLSAE-LHTPhrv 406
Cdd:PRK15481  289 RLAFVASDSATSARLRLRLNS---GTqwvsHLLQDLVYACLTDPE-YQARLAQARLFYAQRRQKLARALQQYgIAIP--- 361

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1541602072 407 lAGEGGMHLALAIDGIDdqrlveQARAFQLA 437
Cdd:PRK15481  362 -SPGDGLNLWLPLDTDS------QATALTLA 385
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
134-430 9.09e-23

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 99.30  E-value: 9.09e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 134 YFPLPLWRRLYDRVLreEGSALLGYGDPAGEPSLRAAIARHLALSRGIDCDA-SQIVITEGALEGVNLCTMLLSEPGDVA 212
Cdd:pfam00155  13 GDTLPAVAKAEKDAL--AGGTRNLYGPTDGHPELREALAKFLGRSPVLKLDReAAVVFGSGAGANIEALIFLLANPGDAI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 213 WVENPGYsgaksAFVKTGLAMTGIPV--------DDEGMCWEGLCA--PSPT--LIFTSPSHqfPYGSVLSARRRLALLE 280
Cdd:pfam00155  91 LVPAPTY-----ASYIRIARLAGGEVvryplydsNDFHLDFDALEAalKEKPkvVLHTSPHN--PTGTVATLEELEKLLD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 281 LARQHNAWIIEDDYDSEFRYTGEPVPAMLGMVNNAP-VVYLGTFSKTL-FPSLRMGFMVLPPALAKAARPAIGSLLRGGH 358
Cdd:pfam00155 164 LAKEHNILLLVDEAYAGFVFGSPDAVATRALLAEGPnLLVVGSFSKAFgLAGWRVGYILGNAAVISQLRKLARPFYSSTH 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1541602072 359 RAEQrTLALFIEEGHYARHLAAMRRLYRKRYRQLREVLSAelhTPHRVLAGEGGMHLALAIDGIDDQRLVEQ 430
Cdd:pfam00155 244 LQAA-AAAALSDPLLVASELEEMRQRIKERRDYLRDGLQA---AGLSVLPSQAGFFLLTGLDPETAKELAQV 311
tyr_nico_aTase TIGR01265
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ...
 157-338 1.57e-10

tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.


Pssm-ID: 188123  Cd Length: 403  Bit Score: 62.74  E-value: 1.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 157 GYGDPAGEPSLRAAIARHLalSRGID--CDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAFVKTGLAM- 233
Cdd:TIGR01265  68 GYAPSVGALAAREAVAEYL--SSDLPgkLTADDVVLTSGCSQAIEICIEALANPGANILVPRPGFPLYDTRAAFSGLEVr 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 234 -------TGIPVDDEGMcwEGLcAPSPT--LIFTSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYTGEP 304
Cdd:TIGR01265 146 lydllpeKDWEIDLDGL--ESL-ADEKTvaIVVINPSN--PCGSVFSRDHLQKIAEVAEKLGIPIIADEIYGHMVFGDAP 220

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1541602072 305 VPAMLGMVNNAPVVYLGTFSKTLF-PSLRMGFMVL 338
Cdd:TIGR01265 221 FIPMASFASIVPVLSLGGISKRWVvPGWRLGWIII 255
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
28-86 8.47e-10

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 54.50  E-value: 8.47e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072   28 LYLALREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGYL-LRSRQGTRV 86
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVqRRPGSGTFV 60
 
Name Accession Description Interval E-value
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 12-481 3.23e-165

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 475.09  E-value: 3.23e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072  12 LHAALKKRGTETLQRALYLALREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGYLL-RSRQGTRVgqfA 90
Cdd:COG1167     1 MLIRLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIEsRPGSGTFV---A 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072  91 PRtIARTLPDPDVRLTKRVARLPAPVPRDTPVMAFTPGTPAINYFPLPLWRRLYDRVLREEGSALLGYGDPAGEPSLRAA 170
Cdd:COG1167    78 AR-LPAPAPAPRAAAAVAAPALRRLLEAAPGVIDLGSGAPDPDLFPLAALRRALRRALRRLPPALLGYGDPQGLPELREA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 171 IARHLAlSRGIDCDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAFVKTGLAMTGIPVDDEGMC---WEG 247
Cdd:COG1167   157 IARYLA-RRGVPASPDQILITSGAQQALDLALRALLRPGDTVAVESPTYPGALAALRAAGLRLVPVPVDEDGLDldaLEA 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 248 LCA-PSPTLIFTSPSHQFPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYTGEPVPAMLGMVNNAPVVYLGTFSKT 326
Cdd:COG1167   236 ALRrHRPRAVYVTPSHQNPTGATMSLERRRALLELARRHGVPIIEDDYDSELRYDGRPPPPLAALDAPGRVIYIGSFSKT 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 327 LFPSLRMGFMVLPPALAKAARPAIGSLLRGGHRAEQRTLALFIEEGHYARHLAAMRRLYRKRYRQLREVLSAELHTPHRV 406
Cdd:COG1167   316 LAPGLRLGYLVAPGRLIERLARLKRATDLGTSPLTQLALAEFLESGHYDRHLRRLRREYRARRDLLLAALARHLPDGLRV 395

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1541602072 407 LAGEGGMHLALAI-DGIDDQRLVEQARAFQLAPAALSGYYLeTKQGQTGLVLGYGNTSASQFAPGIRRLQALITQQ 481
Cdd:COG1167   396 TGPPGGLHLWLELpEGVDAEALAAAALARGILVAPGSAFSA-DGPPRNGLRLGFGAPSEEELEEALRRLAELLREL 470
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 125-431 5.71e-58

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 195.25  E-value: 5.71e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 125 FTPGTPAINYFPLPLWRRlydrVLREEGSALLGYGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALEGVNLCTML 204
Cdd:cd00609     3 LSIGEPDFPPPPEVLEAL----AAAALRAGLLGYYPDPGLPELREAIAEWLGRRGGVDVPPEEIVVTNGAQEALSLLLRA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 205 LSEPGDVAWVENPGYSGAKSAFVKTGLAMTGIPVDDEGMCWEGLC------APSPTLIFTSPsHQFPYGSVLSARRRLAL 278
Cdd:cd00609    79 LLNPGDEVLVPDPTYPGYEAAARLAGAEVVPVPLDEEGGFLLDLElleaakTPKTKLLYLNN-PNNPTGAVLSEEELEEL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 279 LELARQHNAWIIEDDYDSEFRYTGEPVPAMLGMVNNAPVVYLGTFSKTL-FPSLRMGFMVLPP-ALAKAARPAIGSLLRG 356
Cdd:cd00609   158 AELAKKHGILIISDEAYAELVYDGEPPPALALLDAYERVIVLRSFSKTFgLPGLRIGYLIAPPeELLERLKKLLPYTTSG 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1541602072 357 GHRAEQRTLALFIEEGHyaRHLAAMRRLYRKRYRQLREVLSAELhtPHRVLAGEGGMHLALAIDGIDDQRLVEQA 431
Cdd:cd00609   238 PSTLSQAAAAAALDDGE--EHLEELRERYRRRRDALLEALKELG--PLVVVKPSGGFFLWLDLPEGDDEEFLERL 308
AspB COG0436
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...
 157-430 3.19e-26

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440205 [Multi-domain]  Cd Length: 387  Bit Score: 109.83  E-value: 3.19e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 157 GYGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGY---------SGAKSAFV 227
Cdd:COG0436    62 GYTPSAGIPELREAIAAYYKRRYGVDLDPDEILVTNGAKEALALALLALLNPGDEVLVPDPGYpsyraavrlAGGKPVPV 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 228 KTGLAmTG--IPVDDegmcWEGLCAPSPT-LIFTSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDD-YdSEFRYTGE 303
Cdd:COG0436   142 PLDEE-NGflPDPEA----LEAAITPRTKaIVLNSPNN--PTGAVYSREELEALAELAREHDLLVISDEiY-EELVYDGA 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 304 PVPAML---GMVNNapVVYLGTFSKTL-FPSLRMGFMVLPPALAKAARPAIGSLLRGGHRAEQR-TLALFieeGHYARHL 378
Cdd:COG0436   214 EHVSILslpGLKDR--TIVINSFSKSYaMTGWRIGYAVGPPELIAALLKLQSNLTSCAPTPAQYaAAAAL---EGPQDYV 288

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1541602072 379 AAMRRLYRKRYRQLREVLSA---ELHTPhrvlagEGGMHLALAID--GIDDQRLVEQ 430
Cdd:COG0436   289 EEMRAEYRRRRDLLVEGLNEiglSVVKP------EGAFYLFADVPelGLDSEEFAER 339
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 32-437 2.69e-25

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 107.82  E-value: 2.69e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072  32 LREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGYLL-RSRQGTRV-GQFAPRTIARTlpDPDVRLTKRV 109
Cdd:PRK15481   14 IRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQsQGRNGTVIrGSPSPVALEGG--DPGTPLHDLA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 110 ARLPAP--VPRDTPVMAFTPGTPainyfplplwrRLydrvlreegsallgYGDPAGEPSLRAAIARHLALsrgiDCDAS- 186
Cdd:PRK15481   92 GGNPDPqrLPDLSRYFARLSRTP-----------RL--------------YGDAPVSPELHAWAARWLRD----DCPVAf 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 187 QIVITEGALEGVN--LCTMLLsePGDVAWVENPGYSGAKSAFVKTGLAMTGIPVDDEGMCWEG----LCAPSPTLIFTSP 260
Cdd:PRK15481  143 EIDLTSGAIDAIErlLCAHLL--PGDSVAVEDPCFLSSINMLRYAGFSASPVSVDAEGMQPEKleraLAQGARAVILTPR 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 261 SHQfPYGSVLSARRRLALLE-LARQHNAWIIEDDYdseFrytgepvpAMLGMVNNAPVVYLGT--------FSKTLFPSL 331
Cdd:PRK15481  221 AHN-PTGCSLSARRAAALRNlLARYPQVLVIIDDH---F--------ALLSSSPYHSVIPQTTqrwalirsVSKALGPDL 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 332 RMGFMVLPPALAKAARPAIGSllrGG----HRAEQRTLALFIEEGhYARHLAAMRRLYRKRYRQLREVLSAE-LHTPhrv 406
Cdd:PRK15481  289 RLAFVASDSATSARLRLRLNS---GTqwvsHLLQDLVYACLTDPE-YQARLAQARLFYAQRRQKLARALQQYgIAIP--- 361

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1541602072 407 lAGEGGMHLALAIDGIDdqrlveQARAFQLA 437
Cdd:PRK15481  362 -SPGDGLNLWLPLDTDS------QATALTLA 385
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
134-430 9.09e-23

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 99.30  E-value: 9.09e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 134 YFPLPLWRRLYDRVLreEGSALLGYGDPAGEPSLRAAIARHLALSRGIDCDA-SQIVITEGALEGVNLCTMLLSEPGDVA 212
Cdd:pfam00155  13 GDTLPAVAKAEKDAL--AGGTRNLYGPTDGHPELREALAKFLGRSPVLKLDReAAVVFGSGAGANIEALIFLLANPGDAI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 213 WVENPGYsgaksAFVKTGLAMTGIPV--------DDEGMCWEGLCA--PSPT--LIFTSPSHqfPYGSVLSARRRLALLE 280
Cdd:pfam00155  91 LVPAPTY-----ASYIRIARLAGGEVvryplydsNDFHLDFDALEAalKEKPkvVLHTSPHN--PTGTVATLEELEKLLD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 281 LARQHNAWIIEDDYDSEFRYTGEPVPAMLGMVNNAP-VVYLGTFSKTL-FPSLRMGFMVLPPALAKAARPAIGSLLRGGH 358
Cdd:pfam00155 164 LAKEHNILLLVDEAYAGFVFGSPDAVATRALLAEGPnLLVVGSFSKAFgLAGWRVGYILGNAAVISQLRKLARPFYSSTH 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1541602072 359 RAEQrTLALFIEEGHYARHLAAMRRLYRKRYRQLREVLSAelhTPHRVLAGEGGMHLALAIDGIDDQRLVEQ 430
Cdd:pfam00155 244 LQAA-AAAALSDPLLVASELEEMRQRIKERRDYLRDGLQA---AGLSVLPSQAGFFLLTGLDPETAKELAQV 311
PRK05764 PRK05764
aspartate aminotransferase; Provisional
 157-346 1.82e-18

aspartate aminotransferase; Provisional


Pssm-ID: 235596  Cd Length: 393  Bit Score: 87.10  E-value: 1.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 157 GYGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGY---------SGAKSAFV 227
Cdd:PRK05764   63 KYTPAAGIPELREAIAAKLKRDNGLDYDPSQVIVTTGAKQALYNAFMALLDPGDEVIIPAPYWvsypemvklAGGVPVFV 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 228 KTGLAmTGIPVDDEGMcWEGLCAPSPTLIFTSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDD------YDSEFRYT 301
Cdd:PRK05764  143 PTGEE-NGFKLTVEQL-EAAITPKTKALILNSPSN--PTGAVYSPEELEAIADVAVEHDIWVLSDEiyeklvYDGAEFTS 218

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1541602072 302 gePVPAMLGMVNNApvVYLGTFSKTlF--PSLRMGFMVLPPALAKAA 346
Cdd:PRK05764  219 --IASLSPELRDRT--ITVNGFSKA-YamTGWRLGYAAGPKELIKAM 260
PRK06108 PRK06108
pyridoxal phosphate-dependent aminotransferase;
137-478 5.02e-17

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180404  Cd Length: 382  Bit Score: 82.68  E-value: 5.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 137 LPLWRRLYDRV----LREEGSALLG-----YGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALEGVNLCTMLLSE 207
Cdd:PRK06108   27 LPLWFGESDLPtpdfIRDAAAAALAdgetfYTHNLGIPELREALARYVSRLHGVATPPERIAVTSSGVQALMLAAQALVG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 208 PGD------VAW---VENPGYSGAKSAFVKTGLAMTGIPVDDEGMcwegLCAPSP---TLIFTSPSHqfPYGSVLSARRR 275
Cdd:PRK06108  107 PGDevvavtPLWpnlVAAPKILGARVVCVPLDFGGGGWTLDLDRL----LAAITPrtrALFINSPNN--PTGWTASRDDL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 276 LALLELARQHNAWIIEDDYDSEFRY-TGEPVPAMLG-MVNNAPVVYLGTFSKT-LFPSLRMGFMVLPPALAkaarPAIGS 352
Cdd:PRK06108  181 RAILAHCRRHGLWIVADEVYERLYYaPGGRAPSFLDiAEPDDRIIFVNSFSKNwAMTGWRLGWLVAPPALG----QVLEK 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 353 LL------------RGGhraeqrTLALFIEEGHYARHLAAMRRLYRKRYRQLREVLSAELHTPhrvlagEGGMHLALAID 420
Cdd:PRK06108  257 LIeyntscvaqfvqRAA------VAALDEGEDFVAELVARLRRSRDHLVDALRALPGVEVAKP------DGAMYAFFRIP 324

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1541602072 421 GIDDQR-----LVEQARaFQLAPAALSGyyletKQGQTGLVLGYGnTSASQFAPGIRRLQALI 478
Cdd:PRK06108  325 GVTDSLalakrLVDEAG-LGLAPGTAFG-----PGGEGFLRWCFA-RDPARLDEAVERLRRFL 380
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 23-86 2.97e-13

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 64.39  E-value: 2.97e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1541602072  23 TLQRALYLALREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGYL-LRSRQGTRV 86
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVeRRPGRGTFV 65
PRK09148 PRK09148
LL-diaminopimelate aminotransferase;
157-337 1.60e-11

LL-diaminopimelate aminotransferase;


Pssm-ID: 181674 [Multi-domain]  Cd Length: 405  Bit Score: 65.86  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 157 GYGDPAGEPSLRAAIARHLALSRGIDCDA-SQIVITEGALEGV-NLCTMLLSePGDVAWVENPGYSGAKSAFVKTGLAMT 234
Cdd:PRK09148   63 RYSASKGIPGLRRAQAAYYARRFGVKLNPdTQVVATLGSKEGFaNMAQAITA-PGDVILCPNPSYPIHAFGFIMAGGVIR 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 235 GIPVD-DEGMcWEGL------CAPSPT-LIFTSPSHQFPYGSVLSARRRLalLELARQHNAWIIEDDYDSEFRYTGEPVP 306
Cdd:PRK09148  142 SVPAEpDEEF-FPALeravrhSIPKPIaLIVNYPSNPTAYVADLDFYKDV--VAFAKKHDIIILSDLAYSEIYFDGNPPP 218

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1541602072 307 AMLgMVNNAP--VVYLGTFSKTL-FPSLRMGFMV 337
Cdd:PRK09148  219 SVL-QVPGAKdvTVEFTSMSKTFsMAGWRMGFAV 251
PRK05957 PRK05957
pyridoxal phosphate-dependent aminotransferase;
105-476 6.93e-11

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235654  Cd Length: 389  Bit Score: 63.94  E-value: 6.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 105 LTKRVARLPAPV-PRDTPVMAFTPGTPA-----INYFPLPLWRRLYDRVLREEGSALlgYGDPAGEPSLRAAIARHLALS 178
Cdd:PRK05957    4 FTSRMDAVQSPIiPVVGQLIRENPGTISlgqgvVSYPPPPEAIEALNNFLANPENHK--YQAVQGIPPLLEAITQKLQQD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 179 RGIDCDA-SQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAFVKTGLAMTGIPVDDEGMCWEGLCAPSPT--- 254
Cdd:PRK05957   82 NGIELNNeQAIVVTAGSNMAFMNAILAITDPGDEIILNTPYYFNHEMAITMAGCQPILVPTDDNYQLQPEAIEQAITpkt 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 255 -LIFT-SPSHqfPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYTGEP--VPAMLGMVNNApVVYLGTFSKTL-FP 329
Cdd:PRK05957  162 rAIVTiSPNN--PTGVVYPEALLRAVNQICAEHGIYHISDEAYEYFTYDGVKhfSPGSIPGSGNH-TISLYSLSKAYgFA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 330 SLRMGFMVLPPALAKAARPAIGSLLRGGHRAEQRTL--ALFIEEGHYARHLAAM---RRLYRKRYRQLREVLSaeLHTPh 404
Cdd:PRK05957  239 SWRIGYMVIPIHLLEAIKKIQDTILICPPVVSQYAAlgALQVGKSYCQQHLPEIaqvRQILLKSLGQLQDRCT--LHPA- 315

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1541602072 405 rvlagEGGMHLALAID-GIDDQRLVEQ-ARAFQLapAALSGYYLETKQGqTGLVLGYGNTSASQFAPGIRRLQA 476
Cdd:PRK05957  316 -----NGAFYCFLKVNtDLNDFELVKQlIREYRV--AVIPGTTFGMKNG-CYLRIAYGALQKATAKEGIERLVQ 381
PRK08363 PRK08363
alanine aminotransferase; Validated
 158-355 7.35e-11

alanine aminotransferase; Validated


Pssm-ID: 181402  Cd Length: 398  Bit Score: 63.67  E-value: 7.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 158 YGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYS---------GAKSAFVK 228
Cdd:PRK08363   66 YGPSEGLPELREAIVKREKRKNGVDITPDDVRVTAAVTEALQLIFGALLDPGDEILIPGPSYPpytglvkfyGGVPVEYR 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 229 TglamtgipVDDEGmcWEglcaPSP------------TLIFTSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDDYDS 296
Cdd:PRK08363  146 T--------IEEEG--WQ----PDIddirkkitektkAIAVINPNN--PTGALYEKKTLKEILDIAGEHDLPVISDEIYD 209

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1541602072 297 EFRYTGEPV-PAMLgmVNNAPVVYLGTFSKTLFPS-LRMGFMVL--PPALAKAARPAIGSLLR 355
Cdd:PRK08363  210 LMTYEGKHVsPGSL--TKDVPVIVMNGLSKVYFATgWRLGYIYFvdPEGKLAEVREAIDKLAR 270
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 24-86 1.19e-10

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 56.85  E-value: 1.19e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1541602072  24 LQRALYLALREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGYLLR-SRQGTRV 86
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERrQGRGTFV 64
tyr_nico_aTase TIGR01265
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ...
 157-338 1.57e-10

tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.


Pssm-ID: 188123  Cd Length: 403  Bit Score: 62.74  E-value: 1.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 157 GYGDPAGEPSLRAAIARHLalSRGID--CDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAFVKTGLAM- 233
Cdd:TIGR01265  68 GYAPSVGALAAREAVAEYL--SSDLPgkLTADDVVLTSGCSQAIEICIEALANPGANILVPRPGFPLYDTRAAFSGLEVr 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 234 -------TGIPVDDEGMcwEGLcAPSPT--LIFTSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYTGEP 304
Cdd:TIGR01265 146 lydllpeKDWEIDLDGL--ESL-ADEKTvaIVVINPSN--PCGSVFSRDHLQKIAEVAEKLGIPIIADEIYGHMVFGDAP 220

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1541602072 305 VPAMLGMVNNAPVVYLGTFSKTLF-PSLRMGFMVL 338
Cdd:TIGR01265 221 FIPMASFASIVPVLSLGGISKRWVvPGWRLGWIII 255
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
26-98 2.97e-10

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 60.26  E-value: 2.97e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1541602072  26 RALYLALREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGYLLRSR-QGTRVgqfAPRTIARTL 98
Cdd:COG2188     8 LQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQgRGTFV---AEPKIEYPL 78
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
28-86 8.47e-10

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 54.50  E-value: 8.47e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072   28 LYLALREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGYL-LRSRQGTRV 86
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVqRRPGSGTFV 60
PRK07568 PRK07568
pyridoxal phosphate-dependent aminotransferase;
156-309 1.68e-09

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 181036  Cd Length: 397  Bit Score: 59.48  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 156 LGYGDPAGEPSLRAAIARHLAlSRGIDCDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAFVKTGLAMTG 235
Cdd:PRK07568   60 LAYSHSQGIPELREAFAKYYK-KWGIDVEPDEILITNGGSEAILFAMMAICDPGDEILVPEPFYANYNGFATSAGVKIVP 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 236 IPVDDEgmcwEGLCAPSP------------TLIFTSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYTGE 303
Cdd:PRK07568  139 VTTKIE----EGFHLPSKeeieklitpktkAILISNPGN--PTGVVYTKEELEMLAEIAKKHDLFLISDEVYREFVYDGL 212


                  ....*.
gi 1541602072 304 PVPAML 309
Cdd:PRK07568  213 KYTSAL 218
PRK08361 PRK08361
aspartate aminotransferase; Provisional
 141-344 1.92e-09

aspartate aminotransferase; Provisional


Pssm-ID: 236248 [Multi-domain]  Cd Length: 391  Bit Score: 59.51  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 141 RRLYDRVLREEGSALLGYGDP--------------------------AGEPSLRAAIARHLALSRGIDCDASQIVITEGA 194
Cdd:PRK08361   23 RELFERASKMENVISLGIGEPdfdtpknikeaakraldegwthytpnAGIPELREAIAEYYKKFYGVDVDVDNVIVTAGA 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 195 LEGVNLCTMLLSEPGD---------VAWVENPGYSGAKSAFVKTGLAMTGIPVDDEGMcwEGLCAPSPTLIFTSPSHqfP 265
Cdd:PRK08361  103 YEATYLAFESLLEEGDeviipdpafVCYVEDAKIAEAKPIRIPLREENEFQPDPDELL--ELITKRTRMIVINYPNN--P 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 266 YGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYTG-EPVPamlgMVNNAP--VVYLGTFSKTL-FPSLRMGFMVLPPA 341
Cdd:PRK08361  179 TGATLDKEVAKAIADIAEDYNIYILSDEPYEHFLYEGaKHYP----MIKYAPdnTILANSFSKTFaMTGWRLGFVIAPEQ 254


                  ...
gi 1541602072 342 LAK 344
Cdd:PRK08361  255 VIK 257
PRK06836 PRK06836
pyridoxal phosphate-dependent aminotransferase;
146-346 3.34e-09

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180720  Cd Length: 394  Bit Score: 58.67  E-value: 3.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 146 RVLREEGSALLGYGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALEGVNLCTMLLSEPGD----VA--------W 213
Cdd:PRK06836   57 ELAEEEDPGLHGYMPNAGYPEVREAIAESLNRRFGTPLTADHIVMTCGAAGALNVALKAILNPGDevivFApyfveyrfY 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 214 VENpgySGAKSAFVktglamtgiPVDDEGMC--WEGLC-APSP---TLIFTSPSHqfPYGSVLSAR--RRLA-LLELARQ 284
Cdd:PRK06836  137 VDN---HGGKLVVV---------PTDTDTFQpdLDALEaAITPktkAVIINSPNN--PTGVVYSEEtlKALAaLLEEKSK 202

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1541602072 285 ---HNAWIIEDDYDSEFRYTGEPVPAMLGMVNNAPVVYlgTFSKTL-FPSLRMGFMVLPPALAKAA 346
Cdd:PRK06836  203 eygRPIYLISDEPYREIVYDGAEVPYIFKYYDNSIVVY--SFSKSLsLPGERIGYIAVNPEMEDAD 266
PRK08960 PRK08960
pyridoxal phosphate-dependent aminotransferase;
158-346 6.92e-09

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 181595  Cd Length: 387  Bit Score: 57.76  E-value: 6.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 158 YGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAFVKTGLAMTGIP 237
Cdd:PRK08960   65 YTAARGLPALREAIAGFYAQRYGVDVDPERILVTPGGSGALLLASSLLVDPGKHWLLADPGYPCNRHFLRLVEGAAQLVP 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 238 VDDEG----------MCWEglcAPSPTLIFTSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYtGEPVPA 307
Cdd:PRK08960  145 VGPDSryqltpalveRHWN---ADTVGALVASPAN--PTGTLLSRDELAALSQALRARGGHLVVDEIYHGLTY-GVDAAS 218

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1541602072 308 MLGMVNNAPVvyLGTFSKTL-FPSLRMGFMVLPPALAKAA 346
Cdd:PRK08960  219 VLEVDDDAFV--LNSFSKYFgMTGWRLGWLVAPPAAVPEL 256
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
17-98 1.57e-08

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 55.32  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072  17 KKRGTETLQRALYLALREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGyLLRSRQ--GTRVGQFAPRTI 94
Cdd:COG2186     1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALG-LVEVRQggGTFVREPSPWAL 79


                  ....
gi 1541602072  95 ARTL 98
Cdd:COG2186    80 LDPL 83
PRK07550 PRK07550
aminotransferase;
157-342 1.58e-08

aminotransferase;


Pssm-ID: 181026 [Multi-domain]  Cd Length: 386  Bit Score: 56.51  E-value: 1.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 157 GYGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAfvktgLAMTGI 236
Cdd:PRK07550   62 LYGPVEGLPELREAYAAHYSRLYGAAISPEQVHITSGCNQAFWAAMVTLAGAGDEVILPLPWYFNHKMW-----LDMLGI 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 237 ---PVD-DEGMCweGLcaPSP------------TLIFTSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRY 300
Cdd:PRK07550  137 rpvYLPcDEGPG--LL--PDPaaaealitprtrAIALVTPNN--PTGVVYPPELLHELYDLARRHGIALILDETYRDFDS 210

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1541602072 301 TGEPVPAMLGMVN-NAPVVYLGTFSKTL-FPSLRMGFMVLPPAL 342
Cdd:PRK07550  211 GGGAPHDLFADPDwDDTLVHLYSFSKSYaLTGHRVGAVVASPAR 254
HisC COG0079
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ...
 132-347 1.62e-08

Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 439849 [Multi-domain]  Cd Length: 341  Bit Score: 56.29  E-value: 1.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 132 INYFPLPLWRRlydRVLREEGSALLGYGDPAGEPsLRAAIARHLalsrgiDCDASQIVITEGALEGVNLCTMLLSEPGDV 211
Cdd:COG0079    22 ENPYGPPPKVL---EAIAAALDALNRYPDPDATA-LREALAEYY------GVPPEQVLVGNGSDELIQLLARAFLGPGDE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 212 AWVENPGYSGAKSAFVKTGLAMTGIPVDDE-GMCWEGLCA---PSPTLIF-TSPSHqfPYGSVLSARRRLALLELARQHn 286
Cdd:COG0079    92 VLVPEPTFSEYPIAARAAGAEVVEVPLDEDfSLDLDALLAaitERTDLVFlCNPNN--PTGTLLPREELEALLEALPAD- 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1541602072 287 AWIIED----DYdsefrytGEPVPAMLGMVNNAP-VVYLGTFSKTL-FPSLRMGFMVLPPALAKAAR 347
Cdd:COG0079   169 GLVVVDeayaEF-------VPEEDSALPLLARYPnLVVLRTFSKAYgLAGLRLGYAIASPELIAALR 228
PRK08175 PRK08175
aminotransferase; Validated
 157-401 1.58e-07

aminotransferase; Validated


Pssm-ID: 181268 [Multi-domain]  Cd Length: 395  Bit Score: 53.56  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 157 GYGDPAGEPSLRAAIARHLALSRGIDCDA-SQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAFVKTGLAMTG 235
Cdd:PRK08175   62 GYSTSRGIPRLRRAISRWYQDRYDVDIDPeSEAIVTIGSKEGLAHLMLATLDHGDTVLVPNPSYPIHIYGAVIAGAQVRS 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 236 IPVDDEGMCWEGL------CAPSP-TLIFTSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYTGEPVPAM 308
Cdd:PRK08175  142 VPLVEGVDFFNELeraireSYPKPkMMILGFPSN--PTAQCVELEFFEKVVALAKRYDVLVVHDLAYADIVYDGWKAPSI 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 309 L---GMVNNApvVYLGTFSKTL-FPSLRMGFMVLPPALAkAARPAIGSLLRGGHRAEQRTLALFIEEGHyARHLAAMRRL 384
Cdd:PRK08175  220 MqvpGAKDVA--VEFFTLSKSYnMAGWRIGFMVGNPELV-SALARIKSYHDYGTFTPLQVAAIAALEGD-QQCVRDIAEQ 295

                         250
                  ....*....|....*..
gi 1541602072 385 YRKRyrqlREVLSAELH 401
Cdd:PRK08175  296 YKRR----RDVLVKGLH 308
PRK06348 PRK06348
pyridoxal phosphate-dependent aminotransferase;
158-347 1.71e-07

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180537  Cd Length: 384  Bit Score: 53.19  E-value: 1.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 158 YGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAFVKTGlamtGIP 237
Cdd:PRK06348   62 YTDSGGDVELIEEIIKYYSKNYDLSFKRNEIMATVGACHGMYLALQSILDPGDEVIIHEPYFTPYKDQIEMVG----GKP 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 238 V-----DDEGM-----CWEGLCAP-SPTLIFTSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDD-YDS-EFRYTGEP 304
Cdd:PRK06348  138 IiletyEEDGFqinvkKLEALITSkTKAIILNSPNN--PTGAVFSKETLEEIAKIAIEYDLFIISDEvYDGfSFYEDFVP 215

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1541602072 305 VPAMLGMVNNapVVYLGTFSKTL-FPSLRMGFMVLPPALAKAAR 347
Cdd:PRK06348  216 MATLAGMPER--TITFGSFSKDFaMTGWRIGYVIAPDYIIETAK 257
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
32-86 1.92e-07

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 49.41  E-value: 1.92e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1541602072  32 LREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGYL-LRSRQGTRV 86
Cdd:COG1725    19 IKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIeTRRGKGTFV 74
PRK07337 PRK07337
pyridoxal phosphate-dependent aminotransferase;
138-343 1.93e-07

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180937  Cd Length: 388  Bit Score: 53.14  E-value: 1.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 138 PLWRRLYDRVLREegsALLGYGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALEGVNLCTMLLSEPGDVAWVENP 217
Cdd:PRK07337   46 EPVVEAAARALRR---GVTQYTSALGLAPLREAIAAWYARRFGLDVAPERIVVTAGASAALLLACLALVERGDEVLMPDP 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 218 GYSgAKSAFVktgLAMTGIPV--------------DDEGMCWEglcAPSPTLIFTSPSHqfPYGSVLSARRRLALLELAR 283
Cdd:PRK07337  123 SYP-CNRHFV---AAAEGRPVlvpsgpaerfqltaADVEAAWG---ERTRGVLLASPSN--PTGTSIAPDELRRIVEAVR 193

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1541602072 284 QHNAWIIEDDYDSEFRYTGEPVPAmLGMVNNapVVYLGTFSKTL-FPSLRMGFMVLPPALA 343
Cdd:PRK07337  194 ARGGFTIVDEIYQGLSYDAAPVSA-LSLGDD--VITINSFSKYFnMTGWRLGWLVVPEALV 251
PRK06225 PRK06225
pyridoxal phosphate-dependent aminotransferase;
158-449 9.24e-07

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235749 [Multi-domain]  Cd Length: 380  Bit Score: 50.91  E-value: 9.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 158 YGDPAGEPSLRAAIARHLALsrgidcDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGY---SGAKSAFvktGLAMT 234
Cdd:PRK06225   62 YPPPEGFPELRELILKDLGL------DDDEALITAGATESLYLVMRAFLSPGDNAVTPDPGYliiDNFASRF---GAEVI 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 235 GIPVDDEG----MCWEGLCA---PSPTLIF-TSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFryTGEPVP 306
Cdd:PRK06225  133 EVPIYSEEcnykLTPELVKEnmdENTRLIYlIDPLN--PLGSSYTEEEIKEFAEIARDNDAFLLHDCTYRDF--AREHTL 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 307 AMLGMVNNAPVVYlgTFSKTL-FPSLRMGFMVLPPALAKAARPAIGSLLrGGHRAEQRT--LALFIEeghyARHLAAMRR 383
Cdd:PRK06225  209 AAEYAPEHTVTSY--SFSKIFgMAGLRIGAVVATPDLIEVVKSIVINDL-GTNVIAQEAaiAGLKVK----DEWIDRIRR 281

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 384 LYRKRYRQLREVLSAELHTPHRVLAGEGGMhlaLAID----GIDdqrlveqarafqlaPAALSGYYLETK 449
Cdd:PRK06225  282 TTFKNQKLIKEAVDEIEGVFLPVYPSHGNM---MVIDiseaGID--------------PEDLVEYLLERK 334
PTZ00377 PTZ00377
alanine aminotransferase; Provisional
 146-219 1.45e-06

alanine aminotransferase; Provisional


Pssm-ID: 240391 [Multi-domain]  Cd Length: 481  Bit Score: 50.73  E-value: 1.45e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1541602072 146 RVLREEGSALLGYGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALEGVNLC-TMLLSEPGDVAWVENPGY 219
Cdd:PTZ00377   99 EYLNAIGGGTGAYTDSAGYPFVRKAVAAFIERRDGVPKDPSDIFLTDGASSGIKLLlQLLIGDPSDGVMIPIPQY 173
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
21-94 1.66e-06

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 49.15  E-value: 1.66e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1541602072  21 TETLQRALYLALREAILCGRLRSGSHLPgSRTLAHQISVSRNTVNAALDQLTLEGYL-LRSRQGTRVGQFAPRTI 94
Cdd:COG1802     9 RESLAEQVYEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVeIRPNRGARVAPLSPEEI 82
PRK07777 PRK07777
putative succinyldiaminopimelate transaminase DapC;
163-404 2.21e-06

putative succinyldiaminopimelate transaminase DapC;


Pssm-ID: 236095 [Multi-domain]  Cd Length: 387  Bit Score: 49.65  E-value: 2.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 163 GEPSLRAAIARHLALSRGIDCDA-SQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAFVKTGLAMTGIPVDDE 241
Cdd:PRK07777   62 GIPELRAAIAAQRRRRYGLEYDPdTEVLVTVGATEAIAAAVLGLVEPGDEVLLIEPYYDSYAAVIAMAGAHRVPVPLVPD 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 242 GMCW----EGL-CAPSP---TLIFTSPsHQfPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYTGE---PVPAMLG 310
Cdd:PRK07777  142 GRGFaldlDALrAAVTPrtrALIVNSP-HN-PTGTVLTAAELAAIAELAVEHDLLVITDEVYEHLVFDGArhlPLATLPG 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 311 MVNNapVVYLGTFSKTL-FPSLRMGFMVLPPALAKAARPAIGSLLRGGHRAEQRTLALFIeeGHYARHLAAMRRLYRKRY 389
Cdd:PRK07777  220 MRER--TVTISSAAKTFnVTGWKIGWACGPAPLIAAVRAAKQYLTYVGGAPFQPAVAHAL--DHEDAWVAALRDSLQAKR 295

                         250
                  ....*....|....*...
gi 1541602072 390 RQLREVLSA---ELHTPH 404
Cdd:PRK07777  296 DRLAAGLAEagfEVHDSA 313
PLN00145 PLN00145
tyrosine/nicotianamine aminotransferase; Provisional
 157-337 3.02e-06

tyrosine/nicotianamine aminotransferase; Provisional


Pssm-ID: 215074 [Multi-domain]  Cd Length: 430  Bit Score: 49.38  E-value: 3.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 157 GYGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAFVKTGLAM--- 233
Cdd:PLN00145   89 SYSTCVGLLPARRAIAEYLSRDLPYELSTDDIYLTAGCAQAIEIIMSVLAQPGANILLPRPGYPLYEARAVFSGLEVrhf 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 234 -----TGIPVDDEGMcwEGLCAPSPT-LIFTSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYTGEPVPA 307
Cdd:PLN00145  169 dllpeRGWEVDLEGV--EALADENTVaMVIINPNN--PCGSVYSYEHLAKIAETARKLGILVIADEVYDHLTFGSKPFVP 244

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1541602072 308 MLGMVNNAPVVYLGTFSKT-LFPSLRMGFMV 337
Cdd:PLN00145  245 MGVFGEVAPVLTLGSISKRwVVPGWRLGWIA 275
PRK08636 PRK08636
LL-diaminopimelate aminotransferase;
157-345 1.07e-05

LL-diaminopimelate aminotransferase;


Pssm-ID: 236316  Cd Length: 403  Bit Score: 47.78  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 157 GYGDPAGEPSLRAAIARHLALSRGIDCDA-SQIVITEGALEG-VNLcTMLLSEPGDVAWVENPGYSGAKSAFVKTGLAMT 234
Cdd:PRK08636   66 GYSVSKGIYKLRLAICNWYKRKYNVDLDPeTEVVATMGSKEGyVHL-VQAITNPGDVAIVPDPAYPIHSQAFILAGGNVH 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 235 GIPVD-------DEGMCWEGL------CAPSPTLIFTSPSHQfPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYT 301
Cdd:PRK08636  145 KMPLEynedfelDEDQFFENLekalreSSPKPKYVVVNFPHN-PTTATVEKSFYERLVALAKKERFYIISDIAYADITFD 223

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1541602072 302 GEPVPAML---GMVNNAPVVYlgTFSKTL-FPSLRMGFMVLPPALAKA 345
Cdd:PRK08636  224 GYKTPSILeveGAKDVAVESY--TLSKSYnMAGWRVGFVVGNKKLVGA 269
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
32-105 1.52e-05

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 46.55  E-value: 1.52e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1541602072  32 LREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGYLLRsRQGTrvGQFAPRTIARTLPDPDVRL 105
Cdd:PRK09464   19 LEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLR-RQGG--GTFVQSSLWQSFSDPLVEL 89
PTZ00433 PTZ00433
tyrosine aminotransferase; Provisional
 114-365 2.43e-05

tyrosine aminotransferase; Provisional


Pssm-ID: 185613  Cd Length: 412  Bit Score: 46.70  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 114 APVPRDTPVMAFTPGTPAI--NYFPLPLWRRLYDRVLreEGSALLGYGDPAGEPSLRAAIA----RHLAL--SRGIDCDA 185
Cdd:PTZ00433   27 KPSPSPKSIIKLSVGDPTLdgNLLTPAIQTKALVEAV--DSQECNGYPPTVGSPEAREAVAtywrNSFVHkeSLKSTIKK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 186 SQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSGAKSAFVKTGLAMTGIPVDDEGMcWE-------GLC-APSPTLIF 257
Cdd:PTZ00433  105 DNVVLCSGVSHAILMALTALCDEGDNILVPAPGFPHYETVCKAYGIEMRFYNCRPEKD-WEadldeirRLVdDRTKALIM 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 258 TSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYTGEPVPAMLGMVNNAPVVYLGTFSKTLF-PSLRMGFM 336
Cdd:PTZ00433  184 TNPSN--PCGSNFSRKHVEDIIRLCEELRLPLISDEIYAGMVFNGATFTSVADFDTTVPRVILGGTAKNLVvPGWRLGWL 261

                         250       260
                  ....*....|....*....|....*....
gi 1541602072 337 VLPPALAKAarpaiGSLLRGGHRAEQRTL 365
Cdd:PTZ00433  262 LLVDPHGNG-----GDFLDGMKRLGMLVC 285
avtA PRK09440
valine--pyruvate transaminase; Provisional
 128-417 4.40e-05

valine--pyruvate transaminase; Provisional


Pssm-ID: 236517  Cd Length: 416  Bit Score: 45.62  E-value: 4.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 128 GTPAInyfpLP----LWRRLYDRVLREE--GSALLGYGDPAGEPSLRAAIARHLALSRGIDCDASQIVITEGALegvNLC 201
Cdd:PRK09440   38 GNPAH----IPemedYFRDLLADLLASGklTEALGNYDGPQGKDELIEALAALLNERYGWNISPQNIALTNGSQ---SAF 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 202 TMLL------SEPGDVAWV------ENPGYSGAksafvktGLamtgipvdDEGMcwegLCAPSPTLIFTsPSHQFPY--- 266
Cdd:PRK09440  111 FYLFnlfagrRADGSLKKIlfplapEYIGYADA-------GL--------EEDL----FVSYRPNIELL-PEGQFKYhvd 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 267 ----------------------GSVLSARRRLALLELARQHNA-WIIEDDYdsefrytGEPVPAM----LGMVNNAPVVY 319
Cdd:PRK09440  171 fehlhidedtgaicvsrptnptGNVLTDEELEKLDALARQHNIpLLIDNAY-------GPPFPGIifseATPLWNPNIIL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 320 LGTFSKTLFPSLRMGFMVLPPALAKA--ARPAIGSLLRGghRAEQRTLALFIEEGHYARhLAamRRLYRKRYRQLREVLS 397
Cdd:PRK09440  244 CMSLSKLGLPGVRCGIVIADEEIIEAlsNMNGIISLAPG--RLGPAIAAEMIESGDLLR-LS--ETVIRPFYRQKVQLAI 318

                         330       340
                  ....*....|....*....|....*
gi 1541602072 398 AELHT-----PHRVLAGEGGMHLAL 417
Cdd:PRK09440  319 ALLRRylpdePCLIHKPEGAIFLWL 343
PRK09764 PRK09764
GntR family transcriptional regulator;
20-84 5.29e-05

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 44.82  E-value: 5.29e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1541602072  20 GTETLQRALYLALREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTlEGYLLRSRQGT 84
Cdd:PRK09764    2 GHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLV-EQQILESIQGS 65
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 32-88 9.20e-05

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 43.99  E-value: 9.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1541602072  32 LREAILCGRLRSGSHLPGSRTLAHQISVSRNTVNAALDQLTLEGYLLRSR-QGTRVGQ 88
Cdd:PRK10421   11 VRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRgGGTFIRW 68
PRK08912 PRK08912
aminotransferase;
163-219 2.58e-04

aminotransferase;


Pssm-ID: 181580  Cd Length: 387  Bit Score: 43.43  E-value: 2.58e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1541602072 163 GEPSLRAAIARHLALSRGIDCD-ASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGY 219
Cdd:PRK08912   64 GLPELRQAVAAHYARFQGLDLDpETEVMVTSGATEALAAALLALVEPGDEVVLFQPLY 121
PLN02994 PLN02994
1-aminocyclopropane-1-carboxylate synthase
 158-221 3.84e-04

1-aminocyclopropane-1-carboxylate synthase


Pssm-ID: 166635 [Multi-domain]  Cd Length: 153  Bit Score: 40.76  E-value: 3.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1541602072 158 YGDPAGEPSLRAAIARHLALSRG--IDCDASQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSG 221
Cdd:PLN02994   88 FQDYHGLANFRKAIANFMAEARGgrVKFDADMIVLSAGATAANEIIMFCIADPGDAFLVPTPYYAA 153
PRK07683 PRK07683
aminotransferase A; Validated
 158-344 4.34e-04

aminotransferase A; Validated


Pssm-ID: 236075  Cd Length: 387  Bit Score: 42.40  E-value: 4.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 158 YGDPAGEPSLRAAIARHLALSRGIDCDA-SQIVITEGALEGVNLCTMLLSEPGDVAWVENPGYSG---------AKSAFV 227
Cdd:PRK07683   61 YTHNAGLLELRKAACNFVKDKYDLHYSPeSEIIVTIGASEAIDIAFRTILEPGTEVILPAPIYPGyepiirlcgAKPVFI 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541602072 228 ---KTGLAMTGIPVDdegmcwEGLCAPSPTLIFTSPSHqfPYGSVLSARRRLALLELARQHNAWIIEDDYDSEFRYTGEP 304
Cdd:PRK07683  141 dtrSTGFRLTAEALE------NAITEKTRCVVLPYPSN--PTGVTLSKEELQDIADVLKDKNIFVLSDEIYSELVYEQPH 212

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1541602072 305 VP-AMLGMVNNAPVVYLG---TFSKTLFpslRMGFMVLPPALAK 344
Cdd:PRK07683  213 TSiAHFPEMREKTIVINGlskSHSMTGW---RIGFLFAPSYLAK 253
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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