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Conserved domains on  [gi|1541650140|gb|RTN92202|]
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type I toxin-antitoxin system SymE family toxin [Enterobacter bugandensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SymE_toxin super family cl07446
Toxin SymE, type I toxin-antitoxin system; SymE (SOS-induced yjiW gene with similarity to MazE ...
 73-104 1.07e-10

Toxin SymE, type I toxin-antitoxin system; SymE (SOS-induced yjiW gene with similarity to MazE ) is an SOS-induced toxin. It inhibits cell growth, decreases protein synthesis and increases RNA degradation. It may play a role in the recycling of RNAs damaged under SOS response-inducing conditions. It is predicted to have an AbrB fold, similar to that of the antitoxin MazE. Its translation is repressed by the antisense RNA SymR, which acts as an antitoxin.


The actual alignment was detected with superfamily member pfam08845:

Pssm-ID: 385023  Cd Length: 54  Bit Score: 53.88  E-value: 1.07e-10
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1541650140  73 LLLGGEWLTRAGFINGMPVKIRAMKDCIVITP 104
Cdd:pfam08845  23 LRLKGRWLEQAGFATGQPLTITVMPGRLVITP 54
 
Name Accession Description Interval E-value
SymE_toxin pfam08845
Toxin SymE, type I toxin-antitoxin system; SymE (SOS-induced yjiW gene with similarity to MazE ...
 73-104 1.07e-10

Toxin SymE, type I toxin-antitoxin system; SymE (SOS-induced yjiW gene with similarity to MazE ) is an SOS-induced toxin. It inhibits cell growth, decreases protein synthesis and increases RNA degradation. It may play a role in the recycling of RNAs damaged under SOS response-inducing conditions. It is predicted to have an AbrB fold, similar to that of the antitoxin MazE. Its translation is repressed by the antisense RNA SymR, which acts as an antitoxin.


Pssm-ID: 370150  Cd Length: 54  Bit Score: 53.88  E-value: 1.07e-10
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1541650140  73 LLLGGEWLTRAGFINGMPVKIRAMKDCIVITP 104
Cdd:pfam08845  23 LRLKGRWLEQAGFATGQPLTITVMPGRLVITP 54
PRK13605 PRK13605
endoribonuclease SymE; Provisional
 42-129 1.72e-07

endoribonuclease SymE; Provisional


Pssm-ID: 237442  Cd Length: 113  Bit Score: 47.16  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541650140  42 PPNAAPVHPRAETpQDSAACCELYARIDMkyLLLGGEWLTRAGFINGMPVKIRAMKDCIVITPQ----HTRELWGCLEGM 117
Cdd:PRK13605   12 EAEVSPTNNRQLT-VSYASRYPDYSRIPA--ITLKGQWLEAAGFATGTAVDVRVMEGCIVLTAQppaaEESELMQSLRQV 88

                          90
                  ....*....|..
gi 1541650140 118 SVVNINKQKVAQ 129
Cdd:PRK13605   89 CKLSARKQKQVQ 100
 
Name Accession Description Interval E-value
SymE_toxin pfam08845
Toxin SymE, type I toxin-antitoxin system; SymE (SOS-induced yjiW gene with similarity to MazE ...
 73-104 1.07e-10

Toxin SymE, type I toxin-antitoxin system; SymE (SOS-induced yjiW gene with similarity to MazE ) is an SOS-induced toxin. It inhibits cell growth, decreases protein synthesis and increases RNA degradation. It may play a role in the recycling of RNAs damaged under SOS response-inducing conditions. It is predicted to have an AbrB fold, similar to that of the antitoxin MazE. Its translation is repressed by the antisense RNA SymR, which acts as an antitoxin.


Pssm-ID: 370150  Cd Length: 54  Bit Score: 53.88  E-value: 1.07e-10
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1541650140  73 LLLGGEWLTRAGFINGMPVKIRAMKDCIVITP 104
Cdd:pfam08845  23 LRLKGRWLEQAGFATGQPLTITVMPGRLVITP 54
PRK13605 PRK13605
endoribonuclease SymE; Provisional
 42-129 1.72e-07

endoribonuclease SymE; Provisional


Pssm-ID: 237442  Cd Length: 113  Bit Score: 47.16  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541650140  42 PPNAAPVHPRAETpQDSAACCELYARIDMkyLLLGGEWLTRAGFINGMPVKIRAMKDCIVITPQ----HTRELWGCLEGM 117
Cdd:PRK13605   12 EAEVSPTNNRQLT-VSYASRYPDYSRIPA--ITLKGQWLEAAGFATGTAVDVRVMEGCIVLTAQppaaEESELMQSLRQV 88

                          90
                  ....*....|..
gi 1541650140 118 SVVNINKQKVAQ 129
Cdd:PRK13605   89 CKLSARKQKQVQ 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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