NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1541775984|gb|RTP15839|]
View 

iron ABC transporter permease [Enterobacter roggenkampii]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 22-325 3.51e-67

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 212.62  E-value: 3.51e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  22 HLGIGARFIAPQTVVEAFFHFDPRNFDHNIIIRLRLLRLCAAMVTGAALGVAGVLLQSVIRNPLGEPHILGLNAGAALAV 101
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 102 VIASALGLSLPFGRPLIAAAGAAALFLLVLMFSSSGRTGLTPMKVTLCGVAMSAFASSITAAVLIL-DEQTLLSLRTWLA 180
Cdd:COG0609    81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 181 GDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRMAQGLGVSLLKTRLLALLAIALLCGAAVSLAGPIGFIGLV 260
Cdd:COG0609   161 GSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLV 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1541775984 261 VPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLFTPWELATGIMTALVGAPVFILMASRM 325
Cdd:COG0609   241 VPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 22-325 3.51e-67

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 212.62  E-value: 3.51e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  22 HLGIGARFIAPQTVVEAFFHFDPRNFDHNIIIRLRLLRLCAAMVTGAALGVAGVLLQSVIRNPLGEPHILGLNAGAALAV 101
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 102 VIASALGLSLPFGRPLIAAAGAAALFLLVLMFSSSGRTGLTPMKVTLCGVAMSAFASSITAAVLIL-DEQTLLSLRTWLA 180
Cdd:COG0609    81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 181 GDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRMAQGLGVSLLKTRLLALLAIALLCGAAVSLAGPIGFIGLV 260
Cdd:COG0609   161 GSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLV 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1541775984 261 VPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLFTPWELATGIMTALVGAPVFILMASRM 325
Cdd:COG0609   241 VPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 14-324 1.00e-57

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 188.50  E-value: 1.00e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  14 LLAMGAIAHLGIGARFIAPQTVVEAFFHFDPrNFDHNIIIRLRLLRLCAAMVTGAALGVAGVLLQSVIRNPLGEPHILGL 93
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGDD-SLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  94 NAGAALAVVIASALGLSLPFGRPLIAAAGAAALFLLVLMFSSSGRTGLTPMKVTLCGVAMSAFASSITAAVLIL-DEQTL 172
Cdd:pfam01032  80 SSGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 173 LSLRTWLAGDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRMAQGLGVSLLKTRLLALLAIALLCGAAVSLAG 252
Cdd:pfam01032 160 QSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1541775984 253 PIGFIGLVVPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLFTPWELATGIMTALVGAPVFILMASR 324
Cdd:pfam01032 240 PIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
1-325 7.23e-46

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 165.01  E-value: 7.23e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984   1 MMRISLAFLIFTLLLAMGAIAHLGIGARFIAPQTVVEAFFHFDPRNFDHNIIIRLRLLRLCAAMVTGAALGVAGVLLQSV 80
Cdd:PRK10577    7 RRRARLPALLLALLLLLALALTLTQLSAALPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  81 IRNPLGEPHILGLNAGAALAVVIASALGLSLPfGRPLIAAAGAAALFLLVLMFSSSGRTGLTPMKVTLCGVAMSAFASSI 160
Cdd:PRK10577   87 LRNPLASPTTLGVAAGAQLALVLATLFAPALL-ALASQLAAFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 161 TAAVLILDEQTLLSLRTWLAGDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRMAQGLGVSLLKTRLLALLAI 240
Cdd:PRK10577  166 TTLLLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALA 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 241 ALLCGAAVSLAGPIGFIGLVVPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLFTPW--ELATGIMTALVGAPVF 318
Cdd:PRK10577  246 VLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGgeLLPTGAVTALIGAPLL 325


                  ....*..
gi 1541775984 319 ILMASRM 325
Cdd:PRK10577  326 LWLLPRL 332
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 62-321 8.57e-37

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 132.68  E-value: 8.57e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  62 AAMVTGAALGVAGVLLQSVIRNPLGEPHILGLNAGAALAVVIASALGLSLPFGrPLIAAAGAAALFLLVLMFSSSGRTGL 141
Cdd:cd06550     3 AALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNY-ALGAFAFAGALAIALLVLLLASRGGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 142 TPMKVTLCGVAMSAFASSITAAVLILDEQTLLSLRTWLAGDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRM 221
Cdd:cd06550    82 SPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 222 AQGLGVSLLKTRLLALLAIALLCGAAVSLAGPIGFIGLVVPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLFtP 301
Cdd:cd06550   162 AKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL-P 240

                         250       260
                  ....*....|....*....|
gi 1541775984 302 WELATGIMTALVGAPVFILM 321
Cdd:cd06550   241 SELPVGPVTALLGAPYFLYL 260
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 22-325 3.51e-67

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 212.62  E-value: 3.51e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  22 HLGIGARFIAPQTVVEAFFHFDPRNFDHNIIIRLRLLRLCAAMVTGAALGVAGVLLQSVIRNPLGEPHILGLNAGAALAV 101
Cdd:COG0609     1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 102 VIASALGLSLPFGRPLIAAAGAAALFLLVLMFSSSGRTGLTPMKVTLCGVAMSAFASSITAAVLIL-DEQTLLSLRTWLA 180
Cdd:COG0609    81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLaDPEQLRSIVFWLM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 181 GDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRMAQGLGVSLLKTRLLALLAIALLCGAAVSLAGPIGFIGLV 260
Cdd:COG0609   161 GSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLV 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1541775984 261 VPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLFTPWELATGIMTALVGAPVFILMASRM 325
Cdd:COG0609   241 VPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 14-324 1.00e-57

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 188.50  E-value: 1.00e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  14 LLAMGAIAHLGIGARFIAPQTVVEAFFHFDPrNFDHNIIIRLRLLRLCAAMVTGAALGVAGVLLQSVIRNPLGEPHILGL 93
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGDD-SLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  94 NAGAALAVVIASALGLSLPFGRPLIAAAGAAALFLLVLMFSSSGRTGLTPMKVTLCGVAMSAFASSITAAVLIL-DEQTL 172
Cdd:pfam01032  80 SSGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLlNPEAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 173 LSLRTWLAGDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRMAQGLGVSLLKTRLLALLAIALLCGAAVSLAG 252
Cdd:pfam01032 160 QSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1541775984 253 PIGFIGLVVPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLFTPWELATGIMTALVGAPVFILMASR 324
Cdd:pfam01032 240 PIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
1-325 7.23e-46

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 165.01  E-value: 7.23e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984   1 MMRISLAFLIFTLLLAMGAIAHLGIGARFIAPQTVVEAFFHFDPRNFDHNIIIRLRLLRLCAAMVTGAALGVAGVLLQSV 80
Cdd:PRK10577    7 RRRARLPALLLALLLLLALALTLTQLSAALPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  81 IRNPLGEPHILGLNAGAALAVVIASALGLSLPfGRPLIAAAGAAALFLLVLMFSSSGRTGLTPMKVTLCGVAMSAFASSI 160
Cdd:PRK10577   87 LRNPLASPTTLGVAAGAQLALVLATLFAPALL-ALASQLAAFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 161 TAAVLILDEQTLLSLRTWLAGDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRMAQGLGVSLLKTRLLALLAI 240
Cdd:PRK10577  166 TTLLLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALA 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 241 ALLCGAAVSLAGPIGFIGLVVPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLFTPW--ELATGIMTALVGAPVF 318
Cdd:PRK10577  246 VLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGgeLLPTGAVTALIGAPLL 325


                  ....*..
gi 1541775984 319 ILMASRM 325
Cdd:PRK10577  326 LWLLPRL 332
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
63-324 6.25e-42

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 147.92  E-value: 6.25e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  63 AMVTGAALGVAGVLLQSVIRNPLGEPHILGLNAGAALAVVIASALGLSLPFGRPLIAAAGAAALFLLVLMFSSSG--RTG 140
Cdd:PRK11228   58 AVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSPTPFAGYSLAFIAACGGGLSWLLVMTAGGgwRHT 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 141 LTPMKVTLCGVAMSAFASSITAAVLILDEQTLLSLRTWLAGDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDR 220
Cdd:PRK11228  138 HDRNRLILAGIALSALCMALTRITLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDS 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 221 MAQGLGVSLLKTRLLALLAIALLCGAAVSLAGPIGFIGLVVPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLFT 300
Cdd:PRK11228  218 SAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAF 297

                         250       260
                  ....*....|....*....|....
gi 1541775984 301 PWELATGIMTALVGAPVFILMASR 324
Cdd:PRK11228  298 PGELPAGAVLALIGAPCFVWLARR 321
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 3-325 9.36e-42

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 147.96  E-value: 9.36e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984   3 RISLAFLIFTLLLAMGAIAHLGIGARFIAPQTVVEAFFHFDPRnFDHNIIIRLRLLRLCAAMVTGAALGVAGVLLQSVIR 82
Cdd:COG4779    21 RALLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALLGEGDP-GASFVVLELRLPRALAALLVGAALGLSGAIFQSLTR 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  83 NPLGEPHILGLNAGAALAVVIASALGLSLPFGRPLIAAAGAAALFLLVLMFSssGRTGLTPMKVTLCGVAMSAFASSITA 162
Cdd:COG4779   100 NPLASPDIIGITAGASAGAVAAIVVLGGSGLAVALGALAGGLATALLVYLLA--WRGGVSGYRLILVGIGVSAMLTAVNS 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 163 AVLI-LDEQTLLSLRTWLAGDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRMAQGLGVSLLKTRLLALLAIA 241
Cdd:COG4779   178 YLLTrADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAV 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 242 LLCGAAVSLAGPIGFIGLVVPQLIRRLVSVDlRAMVPLSALCGALVLLLADIAARTLFTPWELATGIMTALVGAPVFILM 321
Cdd:COG4779   258 ALAAVATAAAGPIAFVALAAPQIARRLTRSP-GPPLLPSALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLWL 336


                  ....
gi 1541775984 322 ASRM 325
Cdd:COG4779   337 LIRE 340
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
8-325 4.10e-38

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 137.87  E-value: 4.10e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984   8 FLIFTLLLAMGAIAHLGIGARFIAPQTVVEAFfhfDPRNFDHNIIIRLRLLRLCAAMVTGAALGVAGVLLQSVIRNPLGE 87
Cdd:PRK09777    6 VIFITLALAGCALLSLRMGVIPLPWRALLTDW---QAGDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLAS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  88 PHILGLNAGAALAVVIASALGLSLPF-GRPLIAAAGAAALFLLVLMFSSSGRtgltPMKVTLCGVAMSAFASSITAAVLI 166
Cdd:PRK09777   83 PDILGVNHAASLASVGALLLFPSLPVmWLPLLAFIGGMAGLILLKMLAGTHQ----PMKLALTGVALSALWASLTDYLML 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 167 LDEQTLLSLRTWLAGDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRMAQGLGVSLLKTRLLALLAIALLCGA 246
Cdd:PRK09777  159 SRPQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTAT 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1541775984 247 AVSLAGPIGFIGLVVPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLFTPWELATGIMTALVGAPVFILMASRM 325
Cdd:PRK09777  239 GVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVRM 317
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
62-324 1.21e-37

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 141.90  E-value: 1.21e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  62 AAMVTGAALGVAGVLLQSVIRNPLGEPHILGLNAGAALAVVIASALGLSLPFGRpLIAAAGAAALFLLVLMFSSSGRTGL 141
Cdd:PRK10577  403 AALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGW-LLAAALLGALAALALILLLARRGGF 481

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 142 TPMKVTLCGVAMSAFASSITAAVLILDEQTLLSLRTWLAGDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRM 221
Cdd:PRK10577  482 APERLLLTGIALSALFTALIQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDT 561

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 222 AQGLGVSLLKTRLLALLAIALLCGAAVSLAGPIGFIGLVVPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLFTP 301
Cdd:PRK10577  562 ARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFP 641

                         250       260
                  ....*....|....*....|...
gi 1541775984 302 WELATGIMTALVGAPVFILMASR 324
Cdd:PRK10577  642 YQIPAGLLAALIGAPYFLWLLRR 664
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
5-324 3.07e-37

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 135.99  E-value: 3.07e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984   5 SLAFLIFTLLLAMGAIAHLGIGARFIAPQTVVEAFFHFDpRNFDHNIIIRLRLLRLCAAMVTGAALGVAGVLLQSVIRNP 84
Cdd:PRK10441   10 AIAVPGLLLLLIIATALSLLIGAKSLPASVVLEALSGTC-QSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  85 LGEPHILGLNAGAALAVVIASAL-GLSLPFGRPLIAAAGAAALFLLVLMFSSSGRTGLTPMKVTLCGVAMSAFASSITAA 163
Cdd:PRK10441   89 LADPGLLGVNAGASFAIVLGAALfGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSG 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 164 VLILDEQTLLSLRTWLAGDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRMAQGLGVSLLKTRLLALLAIALL 243
Cdd:PRK10441  169 IALLNPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVL 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 244 CGAAVSLAGPIGFIGLVVPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARtLFTPWELATGIMTALVGAPVFILMAS 323
Cdd:PRK10441  249 CGSATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGR-LLVPGELRVSVVSAFIGAPVLIFLVR 327


                  .
gi 1541775984 324 R 324
Cdd:PRK10441  328 R 328
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 62-321 8.57e-37

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 132.68  E-value: 8.57e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  62 AAMVTGAALGVAGVLLQSVIRNPLGEPHILGLNAGAALAVVIASALGLSLPFGrPLIAAAGAAALFLLVLMFSSSGRTGL 141
Cdd:cd06550     3 AALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNY-ALGAFAFAGALAIALLVLLLASRGGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 142 TPMKVTLCGVAMSAFASSITAAVLILDEQTLLSLRTWLAGDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRM 221
Cdd:cd06550    82 SPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDEDL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 222 AQGLGVSLLKTRLLALLAIALLCGAAVSLAGPIGFIGLVVPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLFtP 301
Cdd:cd06550   162 AKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLL-P 240

                         250       260
                  ....*....|....*....|
gi 1541775984 302 WELATGIMTALVGAPVFILM 321
Cdd:cd06550   241 SELPVGPVTALLGAPYFLYL 260
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 3-321 5.82e-36

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 132.28  E-value: 5.82e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984   3 RISLAFLIFTLLLAMGAIAHLGIGARFIAPQTVV---EAFFHFD---PRNFdhniiirlrllrlcAAMVTGAALGVAGVL 76
Cdd:COG4139    10 RDRRWLLLLLLLLLLLFVLSLCAGEVWIPPTQWLseaWQLFVWQlrlPRTL--------------AAVLVGASLAVSGAV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  77 LQSVIRNPLGEPHILGLNAGAALAVVIA-SALGLSLPFGRPLIAAAGAAALFLLVLMFSSsgRTGLTPMKVTLCGVAMSA 155
Cdd:COG4139    76 MQALFENPLAEPGLLGISNGAGVGLVLVvLLGGGLLPPWLLSLAAIAGALLVTLLLLAFA--RRRLSNARLLLIGVALGI 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 156 FASSI-TAAVLILDEQTLLSLRTWLAGDIAGINAQmlQSALWAAAAGFLL-AIGLSPSLNMLALGDRMAQGLGVSLLKTR 233
Cdd:COG4139   154 ICSAImTWAVYFSSSLDLRQLMYWMMGSFGGVDWR--QLWLLLALLPVLLwLCLQGKPLNLLLLGENQARQLGLSVHRWR 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 234 LLALLAIALLCGAAVSLAGPIGFIGLVVPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLFTPWELATGIMTALV 313
Cdd:COG4139   232 NLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTATL 311


                  ....*...
gi 1541775984 314 GAPVFILM 321
Cdd:COG4139   312 GAPVFIWL 319
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 62-321 5.14e-35

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 129.69  E-value: 5.14e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  62 AAMVTGAALGVAGVLLQSVIRNPLGEPHILGLNAGAALAVVIASALGLSLPFGRPLIAAAGAAALFLLVLMFSSSGRTGL 141
Cdd:PRK03784   64 AVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPWALSLCAIAGALLITLILLRFARRHRL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 142 TPMKVTLCGVAMSAFASSI-TAAVLILDEQTLLSLRTWLAGDIAGINAQmlQSALWAAAAGFLLAIGL-SPSLNMLALGD 219
Cdd:PRK03784  144 STSRLLLAGVALGIICSALmTWAVYFSTSLDLRQLMYWMMGGFGGVDWR--QSWLMLALLPVLIWLCCqGRPLNMLALGE 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 220 RMAQGLGVSLLKTRLLALLAIALLCGAAVSLAGPIGFIGLVVPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTLF 299
Cdd:PRK03784  222 ISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLAL 301

                         250       260
                  ....*....|....*....|..
gi 1541775984 300 TPWELATGIMTALVGAPVFILM 321
Cdd:PRK03784  302 ASAELPIGVVTATLGAPVFIWL 323
btuC PRK09535
cobalamin ABC transporter permease BtuC;
63-319 2.27e-28

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 112.54  E-value: 2.27e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  63 AMVTGAALGVAGVLLQSVIRNPLGEPHILGLNAGAALAVVIASALGLSLPFGRPLIAAAGAAALFLLVLMFSSSGrtGLT 142
Cdd:PRK09535  102 AATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLPLAVPFGLQAAAFAGALVAAFGVYAIATEN--GRT 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 143 PMK-VTLCGVAMSAFASSITAAVLILDEQTLLSLRTWLAGDIAGINAQMLQSALWAAAAGFLLAIGLSPSLNMLALGDRM 221
Cdd:PRK09535  180 PVAtLLLAGVAVQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVVLLAYARDLNVLLLGEED 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 222 AQGLGVSLLKTRLLALLAIALLCGAAVSLAGPIGFIGLVVPQLIRRLVSVDLRAMVPLSALCGALVLLLADIAARTlfTP 301
Cdd:PRK09535  260 AHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGASFLVATDTVARS--GP 337

                         250
                  ....*....|....*...
gi 1541775984 302 WELATGIMTALVGAPVFI 319
Cdd:PRK09535  338 AEVPVGIVTAALGAPFFL 355
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
1-314 2.44e-26

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 106.33  E-value: 2.44e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984   1 MMRISLAFLIFTLLLAMG----AIAHLGIGARFIAPQTVVEAFFHFDPRNFDHnIIIRLRLLRLCAAMVTGAALGVAGVL 76
Cdd:PRK10440    1 MIYVSRRLLITCLLLLAAcvaaGLWGLRSGAVTLETSQVFAALMGDAPRSMTM-VVTEWRLPRVLMALLIGAALGVSGAI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984  77 LQSVIRNPLGEPHILGLNAGAALAVVIASALglslpFGRPLIAAAGAAAL---FLLVLMFSSSGRTGLTPMKVTLCGVAM 153
Cdd:PRK10440   80 FQSLMRNPLGSPDVMGFNTGAWSGVLVAMVL-----FGQDLTAIALAAMAggiVTSLLVWLLAWRNGIDTFRLIIIGIGV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 154 SAFASSITAAVLILDE-QTLLSLRTWLAGDIAGIN-AQMLQSALWAAAAgFLLAIGLSPSLNMLALGDRMAQGLGVSLLK 231
Cdd:PRK10440  155 RAMLVAFNTWLLLKASlETALTAGLWNAGSLNGLTwAKTSPSAPIIILM-LIAAALLVRRMRLLEMGDDTACALGVSVER 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1541775984 232 TRLLALLAIALLCGAAVSLAGPIGFIGLVVPQLIRRLvSVDLRAMVPLSALCGALVLLLADIAARTLFTPWELATGIMTA 311
Cdd:PRK10440  234 SRLLLMLVAVVLTAAATALAGPISFIALVAPHIARRL-SGTARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTV 312


                  ...
gi 1541775984 312 LVG 314
Cdd:PRK10440  313 SLG 315
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH