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Conserved domains on  [gi|1546271750|gb|RUQ43647|]
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phosphopyruvate hydratase [Micrococcus sp. HSID17227]

Protein Classification

phosphopyruvate hydratase( domain architecture ID 11414960)

phosphopyruvate hydratase (enolase) catalyzes the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways

CATH:  3.20.20.120|3.30.390.10
EC:  4.2.1.11
Gene Ontology:  GO:0004634|GO:0000015|GO:0006096|GO:0000287
PubMed:  8994873|8605183
SCOP:  3001064|3000476

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 27-438 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 553.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750  27 TIDAVHGARILDSRGYPTVRVSLELDDGRTVTGDAPAGASTGAHEAVELRDGG-SAFGGRDVTQALHLIDTDISGLLTGR 105
Cdd:COG0148     3 RIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDkSRYLGKGVLKAVENVNEEIAPALIGM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 106 SWSAIGQIDAALAELDGTTGYRRLGANSVVATSIAASRALAHAADLPLWQWIAEITGSTprMPVPHFNVLNGGAHAANEL 185
Cdd:COG0148    83 DATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKT--LPVPMMNIINGGAHADNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 186 DFQEFMIAPVNAGSMADAVRIGADVYHALAALVRDRFGSLGLGDEGGFAPSIAAPEEALDLLVDAIRTAGYEPGvDQVAI 265
Cdd:COG0148   161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPG-EDIAL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 266 ALDPAANEFSQgDGSYRVLND--SLDRDGLVDYYRHLIDTYPIRSIEDAFAEDDHEGFRRMQAALGDRIQIVGDDLYVTD 343
Cdd:COG0148   240 ALDVAASEFYK-DGKYHLKGEgkELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTN 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 344 PQRIRDGGEQQLTNAALIKPNQIGTVSQTLGAIATAKSIGMASMVSHRSGETTDTFIADLVVGTGTGQIKSGAPGRGERV 423
Cdd:COG0148   319 PKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERV 398

                         410
                  ....*....|....*
gi 1546271750 424 AKYNRLTEIAEQHPE 438
Cdd:COG0148   399 AKYNQLLRIEEELGD 413
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 27-438 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 553.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750  27 TIDAVHGARILDSRGYPTVRVSLELDDGRTVTGDAPAGASTGAHEAVELRDGG-SAFGGRDVTQALHLIDTDISGLLTGR 105
Cdd:COG0148     3 RIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDkSRYLGKGVLKAVENVNEEIAPALIGM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 106 SWSAIGQIDAALAELDGTTGYRRLGANSVVATSIAASRALAHAADLPLWQWIAEITGSTprMPVPHFNVLNGGAHAANEL 185
Cdd:COG0148    83 DATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKT--LPVPMMNIINGGAHADNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 186 DFQEFMIAPVNAGSMADAVRIGADVYHALAALVRDRFGSLGLGDEGGFAPSIAAPEEALDLLVDAIRTAGYEPGvDQVAI 265
Cdd:COG0148   161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPG-EDIAL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 266 ALDPAANEFSQgDGSYRVLND--SLDRDGLVDYYRHLIDTYPIRSIEDAFAEDDHEGFRRMQAALGDRIQIVGDDLYVTD 343
Cdd:COG0148   240 ALDVAASEFYK-DGKYHLKGEgkELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTN 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 344 PQRIRDGGEQQLTNAALIKPNQIGTVSQTLGAIATAKSIGMASMVSHRSGETTDTFIADLVVGTGTGQIKSGAPGRGERV 423
Cdd:COG0148   319 PKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERV 398

                         410
                  ....*....|....*
gi 1546271750 424 AKYNRLTEIAEQHPE 438
Cdd:COG0148   399 AKYNQLLRIEEELGD 413
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 30-435 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 538.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750  30 AVHGARILDSRGYPTVRVSLELDDGRTVTGDAPAGASTGAHEAVELRDGG-SAFGGRDVTQALHLIDTDISGLLTGRSWS 108
Cdd:cd03313     1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDkSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 109 AIGQIDAALAELDGTTGYRRLGANSVVATSIAASRALAHAADLPLWQWIAEITgsTPRMPVPHFNVLNGGAHAANELDFQ 188
Cdd:cd03313    81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLA--AYVLPVPMFNVINGGAHAGNKLDFQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 189 EFMIAPVNAGSMADAVRIGADVYHALAALVRDRFGSL--GLGDEGGFAPSIAAPEEALDLLVDAIRTAGYEPGVDqVAIA 266
Cdd:cd03313   159 EFMIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGGLLatNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKK-IAIA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 267 LDPAANEF-SQGDGSYRVLND-SLDRDGLVDYYRHLIDTYPIRSIEDAFAEDDHEGFRRMQAALGDRIQIVGDDLYVTDP 344
Cdd:cd03313   238 LDVAASEFyDEGKYVYDSDEGkKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTNP 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 345 QRIRDGGEQQLTNAALIKPNQIGTVSQTLGAIATAKSIGMASMVSHRSGETTDTFIADLVVGTGTGQIKSGAPGRGERVA 424
Cdd:cd03313   318 ERLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERTA 397

                         410
                  ....*....|.
gi 1546271750 425 KYNRLTEIAEQ 435
Cdd:cd03313   398 KYNQLLRIEEE 408
eno PRK00077
enolase; Provisional
 26-435 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 529.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750  26 VTIDAVHGARILDSRGYPTVRVSLELDDGRTVTGDAPAGASTGAHEAVELRDGG-SAFGGRDVTQALHLIDTDISGLLTG 104
Cdd:PRK00077    2 SKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDkSRYLGKGVLKAVENVNEEIAPALIG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 105 RSWSAIGQIDAALAELDGTTGYRRLGANSVVATSIAASRALAHAADLPLWQWIAEITGSTprMPVPHFNVLNGGAHAANE 184
Cdd:PRK00077   82 LDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKV--LPVPMMNIINGGAHADNN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 185 LDFQEFMIAPVNAGSMADAVRIGADVYHALAALVRDRFGSLGLGDEGGFAPSIAAPEEALDLLVDAIRTAGYEPGVDqVA 264
Cdd:PRK00077  160 VDIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGED-IA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 265 IALDPAANEFSQgDGSYRVLNDSLDRDGLVDYYRHLIDTYPIRSIEDAFAEDDHEGFRRMQAALGDRIQIVGDDLYVTDP 344
Cdd:PRK00077  239 LALDCAASEFYK-DGKYVLEGEGLTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLFVTNT 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 345 QRIRDGGEQQLTNAALIKPNQIGTVSQTLGAIATAKSIGMASMVSHRSGETTDTFIADLVVGTGTGQIKSGAPGRGERVA 424
Cdd:PRK00077  318 KRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIA 397

                         410
                  ....*....|.
gi 1546271750 425 KYNRLTEIAEQ 435
Cdd:PRK00077  398 KYNQLLRIEEE 408
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 28-442 1.67e-165

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 472.23  E-value: 1.67e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750  28 IDAVHGARILDSRGYPTVRVSLELDDGRTVTGDAPAGASTGAHEAVELRDGG-SAFGGRDVTQALHLIDTDISGLLTGRS 106
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDkKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 107 WSAIGQIDAALAELDGTTGYRRLGANSVVATSIAASRALAHAADLPLWQWIAEITGSTprMPVPHFNVLNGGAHAANELD 186
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYV--LPVPMMNIINGGAHADNNLD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 187 FQEFMIAPVNAGSMADAVRIGADVYHALAALVRDRFGSLGLGDEGGFAPSIAAPEEALDLLVDAIRTAGYEPGVDqVAIA 266
Cdd:TIGR01060 159 FQEFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGED-VALA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 267 LDPAANEF-SQGDGSYRVL--NDSLDRDGLVDYYRHLIDTYPIRSIEDAFAEDDHEGFRRMQAALGDRIQIVGDDLYVTD 343
Cdd:TIGR01060 238 LDCAASEFyDEEDGKYVYKgeNKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVTN 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 344 PQRIRDGGEQQLTNAALIKPNQIGTVSQTLGAIATAKSIGMASMVSHRSGETTDTFIADLVVGTGTGQIKSGAPGRGERV 423
Cdd:TIGR01060 318 TEILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSERI 397

                         410
                  ....*....|....*....
gi 1546271750 424 AKYNRLTEIAEqhpELPYG 442
Cdd:TIGR01060 398 AKYNQLLRIEE---ELGDS 413
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
167-435 4.81e-115

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 339.07  E-value: 4.81e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 167 MPVPHFNVLNGGAHAANELDFQEFMIAPVNAGSMADAVRIGADVYHALAALVRDRFGSLG--LGDEGGFAPSIAAPEEAL 244
Cdd:pfam00113   4 LPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYGQSAtnVGDEGGFAPNLQSNKEAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 245 DLLVDAIRTAGYEPgvdQVAIALDPAANEF-SQGDGSYRVLNDSLDRDG--------LVDYYRHLIDTYPIRSIEDAFAE 315
Cdd:pfam00113  84 DLIVEAIEKAGYKG---KIKIAMDVASSEFyNKKDGKYDLDFKGEKSDKskkltsaqLADLYEELVKKYPIVSIEDPFDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 316 DDHEGFRRMQAALGDRIQIVGDDLYVTDPQRIRDGGEQQLTNAALIKPNQIGTVSQTLGAIATAKSIGMASMVSHRSGET 395
Cdd:pfam00113 161 DDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGET 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1546271750 396 TDTFIADLVVGTGTGQIKSGAPGRGERVAKYNRLTEIAEQ 435
Cdd:pfam00113 241 EDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEE 280
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 27-438 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 553.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750  27 TIDAVHGARILDSRGYPTVRVSLELDDGRTVTGDAPAGASTGAHEAVELRDGG-SAFGGRDVTQALHLIDTDISGLLTGR 105
Cdd:COG0148     3 RIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDkSRYLGKGVLKAVENVNEEIAPALIGM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 106 SWSAIGQIDAALAELDGTTGYRRLGANSVVATSIAASRALAHAADLPLWQWIAEITGSTprMPVPHFNVLNGGAHAANEL 185
Cdd:COG0148    83 DATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKT--LPVPMMNIINGGAHADNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 186 DFQEFMIAPVNAGSMADAVRIGADVYHALAALVRDRFGSLGLGDEGGFAPSIAAPEEALDLLVDAIRTAGYEPGvDQVAI 265
Cdd:COG0148   161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPG-EDIAL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 266 ALDPAANEFSQgDGSYRVLND--SLDRDGLVDYYRHLIDTYPIRSIEDAFAEDDHEGFRRMQAALGDRIQIVGDDLYVTD 343
Cdd:COG0148   240 ALDVAASEFYK-DGKYHLKGEgkELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDDLFVTN 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 344 PQRIRDGGEQQLTNAALIKPNQIGTVSQTLGAIATAKSIGMASMVSHRSGETTDTFIADLVVGTGTGQIKSGAPGRGERV 423
Cdd:COG0148   319 PKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPSRSERV 398

                         410
                  ....*....|....*
gi 1546271750 424 AKYNRLTEIAEQHPE 438
Cdd:COG0148   399 AKYNQLLRIEEELGD 413
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 30-435 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 538.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750  30 AVHGARILDSRGYPTVRVSLELDDGRTVTGDAPAGASTGAHEAVELRDGG-SAFGGRDVTQALHLIDTDISGLLTGRSWS 108
Cdd:cd03313     1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDkSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 109 AIGQIDAALAELDGTTGYRRLGANSVVATSIAASRALAHAADLPLWQWIAEITgsTPRMPVPHFNVLNGGAHAANELDFQ 188
Cdd:cd03313    81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLA--AYVLPVPMFNVINGGAHAGNKLDFQ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 189 EFMIAPVNAGSMADAVRIGADVYHALAALVRDRFGSL--GLGDEGGFAPSIAAPEEALDLLVDAIRTAGYEPGVDqVAIA 266
Cdd:cd03313   159 EFMIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGGLLatNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKK-IAIA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 267 LDPAANEF-SQGDGSYRVLND-SLDRDGLVDYYRHLIDTYPIRSIEDAFAEDDHEGFRRMQAALGDRIQIVGDDLYVTDP 344
Cdd:cd03313   238 LDVAASEFyDEGKYVYDSDEGkKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFVTNP 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 345 QRIRDGGEQQLTNAALIKPNQIGTVSQTLGAIATAKSIGMASMVSHRSGETTDTFIADLVVGTGTGQIKSGAPGRGERVA 424
Cdd:cd03313   318 ERLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSERTA 397

                         410
                  ....*....|.
gi 1546271750 425 KYNRLTEIAEQ 435
Cdd:cd03313   398 KYNQLLRIEEE 408
eno PRK00077
enolase; Provisional
 26-435 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 529.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750  26 VTIDAVHGARILDSRGYPTVRVSLELDDGRTVTGDAPAGASTGAHEAVELRDGG-SAFGGRDVTQALHLIDTDISGLLTG 104
Cdd:PRK00077    2 SKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDkSRYLGKGVLKAVENVNEEIAPALIG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 105 RSWSAIGQIDAALAELDGTTGYRRLGANSVVATSIAASRALAHAADLPLWQWIAEITGSTprMPVPHFNVLNGGAHAANE 184
Cdd:PRK00077   82 LDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKV--LPVPMMNIINGGAHADNN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 185 LDFQEFMIAPVNAGSMADAVRIGADVYHALAALVRDRFGSLGLGDEGGFAPSIAAPEEALDLLVDAIRTAGYEPGVDqVA 264
Cdd:PRK00077  160 VDIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGED-IA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 265 IALDPAANEFSQgDGSYRVLNDSLDRDGLVDYYRHLIDTYPIRSIEDAFAEDDHEGFRRMQAALGDRIQIVGDDLYVTDP 344
Cdd:PRK00077  239 LALDCAASEFYK-DGKYVLEGEGLTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDDLFVTNT 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 345 QRIRDGGEQQLTNAALIKPNQIGTVSQTLGAIATAKSIGMASMVSHRSGETTDTFIADLVVGTGTGQIKSGAPGRGERVA 424
Cdd:PRK00077  318 KRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLSRSERIA 397

                         410
                  ....*....|.
gi 1546271750 425 KYNRLTEIAEQ 435
Cdd:PRK00077  398 KYNQLLRIEEE 408
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 28-442 1.67e-165

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 472.23  E-value: 1.67e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750  28 IDAVHGARILDSRGYPTVRVSLELDDGRTVTGDAPAGASTGAHEAVELRDGG-SAFGGRDVTQALHLIDTDISGLLTGRS 106
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDkKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 107 WSAIGQIDAALAELDGTTGYRRLGANSVVATSIAASRALAHAADLPLWQWIAEITGSTprMPVPHFNVLNGGAHAANELD 186
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYV--LPVPMMNIINGGAHADNNLD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 187 FQEFMIAPVNAGSMADAVRIGADVYHALAALVRDRFGSLGLGDEGGFAPSIAAPEEALDLLVDAIRTAGYEPGVDqVAIA 266
Cdd:TIGR01060 159 FQEFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGED-VALA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 267 LDPAANEF-SQGDGSYRVL--NDSLDRDGLVDYYRHLIDTYPIRSIEDAFAEDDHEGFRRMQAALGDRIQIVGDDLYVTD 343
Cdd:TIGR01060 238 LDCAASEFyDEEDGKYVYKgeNKQLTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFVTN 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 344 PQRIRDGGEQQLTNAALIKPNQIGTVSQTLGAIATAKSIGMASMVSHRSGETTDTFIADLVVGTGTGQIKSGAPGRGERV 423
Cdd:TIGR01060 318 TEILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSERI 397

                         410
                  ....*....|....*....
gi 1546271750 424 AKYNRLTEIAEqhpELPYG 442
Cdd:TIGR01060 398 AKYNQLLRIEE---ELGDS 413
PTZ00081 PTZ00081
enolase; Provisional
 25-435 1.05e-155

enolase; Provisional


Pssm-ID: 240259 [Multi-domain]  Cd Length: 439  Bit Score: 447.96  E-value: 1.05e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750  25 PVTIDAVHGARILDSRGYPTVRVSLELDDG--RTVtgdAPAGASTGAHEAVELRDGG-SAFGGRDVTQALHLIDTDISGL 101
Cdd:PTZ00081    1 MSTIKSIKAREILDSRGNPTVEVDLTTEKGvfRAA---VPSGASTGIYEALELRDGDkSRYLGKGVLKAVENVNEIIAPA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 102 LTGRSWSAIGQIDAALAE-LDGT---TGYRR--LGANSVVATSIAASRALAHAADLPLWQWIAEITGSTP---RMPVPHF 172
Cdd:PTZ00081   78 LIGKDVTDQKKLDKLMVEqLDGTkneWGWCKskLGANAILAVSMAVARAAAAAKGVPLYKYLAQLAGKPTdkfVLPVPCF 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 173 NVLNGGAHAANELDFQEFMIAPVNAGSMADAVRIGADVYHALAALVRDRFG--SLGLGDEGGFAPSIAAPEEALDLLVDA 250
Cdd:PTZ00081  158 NVINGGKHAGNKLAFQEFMIAPVGAPSFKEALRMGAEVYHSLKSVIKKKYGldATNVGDEGGFAPNIKDPEEALDLLVEA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 251 IRTAGYEpgvDQVAIALDPAANEFSQGDGSYRVLN-DSLDRDG--------LVDYYRHLIDTYPIRSIEDAFAEDDHEGF 321
Cdd:PTZ00081  238 IKKAGYE---GKVKICMDVAASEFYDKEKKVYDLDfKNPNNDKsnkltgeeLVELYLDLVKKYPIVSIEDPFDQDDWEAY 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 322 RRMQAALGDRIQIVGDDLYVTDPQRIRDGGEQQLTNAALIKPNQIGTVSQTLGAIATAKSIGMASMVSHRSGETTDTFIA 401
Cdd:PTZ00081  315 AKLTAAIGQKVQIVGDDLLVTNPTRIKKAIEKKACNALLLKVNQIGTVTEAIEAAKLAQKNGWGVMVSHRSGETEDTFIA 394

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1546271750 402 DLVVGTGTGQIKSGAPGRGERVAKYNRLTEIAEQ 435
Cdd:PTZ00081  395 DLVVGLGTGQIKTGAPCRSERLAKYNQLLRIEEE 428
PLN00191 PLN00191
enolase
 25-435 5.25e-147

enolase


Pssm-ID: 215095 [Multi-domain]  Cd Length: 457  Bit Score: 426.43  E-value: 5.25e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750  25 PVTIDAVHGARILDSRGYPTVRVSLELDDGrTVTGDAPAGASTGAHEAVELRDGGSAFGGRDVTQALHLIDTDISGLLTG 104
Cdd:PLN00191   25 MATITKVKARQIIDSRGNPTVEVDLHTSKG-MFRAAVPSGASTGIYEALELRDGDKDYLGKGVLKAVKNVNEIIAPALIG 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 105 RSWSAIGQIDAALAELDGTTGYRRLGANSVVATSIAASRALAHAADLPLWQWIAEITGSTPR-MPVPHFNVLNGGAHAAN 183
Cdd:PLN00191  104 MDPTDQTQIDNFMLELDGTPNKGKLGANAILAVSLAVCKAGAAEKGVPLYKHIADLAGNKKLvLPVPAFNVINGGSHAGN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 184 ELDFQEFMIAPVNAGSMADAVRIGADVYHALAALVRDRFGSLG--LGDEGGFAPSIAAPEEALDLLVDAIRTAGYEpgvD 261
Cdd:PLN00191  184 KLAMQEFMILPVGASSFKEAMQMGSEVYHHLKAVIKKKYGQDAcnVGDEGGFAPNIQDNKEGLELLKEAIEKAGYT---G 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 262 QVAIALDPAANEFSQGDGSYRVLNDSLDRDG--------LVDYYRHLIDTYPIRSIEDAFAEDDHEGFRRMQAalGDRIQ 333
Cdd:PLN00191  261 KIKIGMDVAASEFYTKDKKYDLDFKEENNDGsnkksgdeLIDLYKEFVSDYPIVSIEDPFDQDDWEHWAKLTS--LEDVQ 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 334 IVGDDLYVTDPQRIRDGGEQQLTNAALIKPNQIGTVSQTLGAIATAKSIGMASMVSHRSGETTDTFIADLVVGTGTGQIK 413
Cdd:PLN00191  339 IVGDDLLVTNPKRVAKAIQEKACNALLLKVNQIGTVTESIEAVKMSKAAGWGVMTSHRSGETEDSFIADLAVGLATGQIK 418

                         410       420
                  ....*....|....*....|..
gi 1546271750 414 SGAPGRGERVAKYNRLTEIAEQ 435
Cdd:PLN00191  419 TGAPCRSERLAKYNQLLRIEEE 440
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
167-435 4.81e-115

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 339.07  E-value: 4.81e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 167 MPVPHFNVLNGGAHAANELDFQEFMIAPVNAGSMADAVRIGADVYHALAALVRDRFGSLG--LGDEGGFAPSIAAPEEAL 244
Cdd:pfam00113   4 LPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYGQSAtnVGDEGGFAPNLQSNKEAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 245 DLLVDAIRTAGYEPgvdQVAIALDPAANEF-SQGDGSYRVLNDSLDRDG--------LVDYYRHLIDTYPIRSIEDAFAE 315
Cdd:pfam00113  84 DLIVEAIEKAGYKG---KIKIAMDVASSEFyNKKDGKYDLDFKGEKSDKskkltsaqLADLYEELVKKYPIVSIEDPFDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 316 DDHEGFRRMQAALGDRIQIVGDDLYVTDPQRIRDGGEQQLTNAALIKPNQIGTVSQTLGAIATAKSIGMASMVSHRSGET 395
Cdd:pfam00113 161 DDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHRSGET 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1546271750 396 TDTFIADLVVGTGTGQIKSGAPGRGERVAKYNRLTEIAEQ 435
Cdd:pfam00113 241 EDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEE 280
Enolase_N pfam03952
Enolase, N-terminal domain;
28-157 8.88e-36

Enolase, N-terminal domain;


Pssm-ID: 461105 [Multi-domain]  Cd Length: 131  Bit Score: 128.65  E-value: 8.88e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750  28 IDAVHGARILDSRGYPTVRVSLELDDGRTVTGDAPAGASTGAHEAVELRDG-GSAFGGRDVTQALHLIDTDISGLLTGRS 106
Cdd:pfam03952   1 ITKVKAREILDSRGNPTVEVEVTLEDGTFGRAAVPSGASTGEHEAVELRDGdKSRYGGKGVLKAVENVNEIIAPALIGMD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1546271750 107 WSAIGQIDAALAELDGTTGYRRLGANSVVATSIAASRALAHAADLPLWQWI 157
Cdd:pfam03952  81 ATDQRAIDRALIELDGTENKSKLGANAILGVSLAVAKAAAAALGLPLYRYL 131
enolase_like cd00308
Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is ...
 285-409 1.05e-07

Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Enolase superfamily contains different enzymes, like enolases, glutarate-, fucanate- and galactonate dehydratases, o-succinylbenzoate synthase, N-acylamino acid racemase, L-alanine-DL-glutamate epimerase, mandelate racemase, muconate lactonizing enzyme and 3-methylaspartase.


Pssm-ID: 238188 [Multi-domain]  Cd Length: 229  Bit Score: 52.33  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 285 NDSLDRDGLVDYYRHLIDtYPIRSIEDAFAEDDHEGFRRMQAALGdrIQIVGDDLYVTDPQRIRdGGEQQLTNAALIKPN 364
Cdd:cd00308   102 NGAWTPKEAIRLIRALEK-YGLAWIEEPCAPDDLEGYAALRRRTG--IPIAADESVTTVDDALE-ALELGAVDILQIKPT 177

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1546271750 365 QIGTVSQTLGAIATAKSIGMASMVSHRSG-ETTDTFIADLVVGTGT 409
Cdd:cd00308   178 RVGGLTESRRAADLAEAFGIRVMVHGTLEsSIGTAAALHLAAALPN 223
PTZ00378 PTZ00378
hypothetical protein; Provisional
 28-370 1.48e-03

hypothetical protein; Provisional


Pssm-ID: 173571 [Multi-domain]  Cd Length: 518  Bit Score: 41.01  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750  28 IDAVHGARILDSRGYPTVRVSLELDDGRTV-TGD----APAGASTGAHEAVELRDGGS-AFGGRDVTQALHLidtdisGL 101
Cdd:PTZ00378   51 IRALVHNEVLSPAGETVLRFTLELLNGMEVsSGAllspSHGERDGEADATLDPAEYTTeALQNSYFPRLLQL------GA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 102 LTGRSW-SAIGQIDAALAELDGTTGYRRlgANSVVATSIAASRALahaadLPLWQWIAEITGS---TPRMPVPHFNV--L 175
Cdd:PTZ00378  125 RDQREFdSTLRAALSTSPLANVGSAVQW--ALSIVASLAAARCRS-----VPLFQYLRALFGSltsVETFSMPQLCItfF 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 176 NGGAHAANELDFQEFMIAPVN-AGSMADAV--RIGADVYH---ALAALVRDRfGSLGLGDEGGFAPSIAAPEEALdllvd 249
Cdd:PTZ00378  198 GPGNPSTARLALKSVLFSPVMpSGTVLRERmqKIFAAFHHfcqSHNSSVRSD-GSLHWDGFANLTDAVKLATEAL----- 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1546271750 250 aiRTAGYEPGVD------------QVAIALDPAANEFSQGDGSYRVLNDSLDR------DGLVDYYRHLIDTYP--IRSI 309
Cdd:PTZ00378  272 --RAVQLTPGTDvclglrmaasttRVPATAVADGGAWKEAKDDCEVLYSLFPGepdvtgDQLSEYVREQLQAVPdiVVYV 349

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1546271750 310 EDAFAEDDHEGFRRMQAALGDRIQIVGDDLYV-TDPQRIRDGGEQQLTNAALIKPNQIGTVS 370
Cdd:PTZ00378  350 EDTHCDEDTFGLQRLQAALGDSIVLSGVDVYArSEYKKVESGLRGLWTSNIVLNPCAIGTLS 411
PRK08350 PRK08350
hypothetical protein; Provisional
 113-170 5.80e-03

hypothetical protein; Provisional


Pssm-ID: 169397 [Multi-domain]  Cd Length: 341  Bit Score: 38.63  E-value: 5.80e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1546271750 113 IDAALAELDGTTGYRRLGANSVVATSIAASRALAHAADLPLWQWIAeitGS-TPRMPVP 170
Cdd:PRK08350   75 IDSYLWEIDGTEDFSHIGANTALAVSVAVAKAAANSKNMPLYSYIG---GTfTTELPVP 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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