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Conserved domains on  [gi|1549067765|gb|RVE34961|]
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RusA family crossover junction endodeoxyribonuclease, partial [Escherichia coli]

Protein Classification

RusA family crossover junction endodeoxyribonuclease( domain architecture ID 10008623)

RusA family crossover junction endodeoxyribonuclease similar to Lactococcus phage RusA that resolves Holliday junction intermediates and promotes DNA repair

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RusA COG4570
Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination ...
 1-85 1.86e-26

Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination and repair];


:

Pssm-ID: 443627  Cd Length: 120  Bit Score: 93.80  E-value: 1.86e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549067765   1 RYRRAVALIVRQQRLKLSLSGRLAIKIIAE-PPDKRRRDLDNILKAPLDALTHAEVLIDDEQFDEINIVRGQPVPGGRLG 79
Cdd:COG4570    32 AYRNLVALAARQQMPKKPLEGPVAVEIKFYfPPDRRKPDLDNLLKAILDALTGAGVWKDDSQVVDLIVEKRYDDKGPRVE 111


                  ....*.
gi 1549067765  80 VKIYEI 85
Cdd:COG4570   112 VEIEEL 117
 
Name Accession Description Interval E-value
RusA COG4570
Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination ...
 1-85 1.86e-26

Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination and repair];


Pssm-ID: 443627  Cd Length: 120  Bit Score: 93.80  E-value: 1.86e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549067765   1 RYRRAVALIVRQQRLKLSLSGRLAIKIIAE-PPDKRRRDLDNILKAPLDALTHAEVLIDDEQFDEINIVRGQPVPGGRLG 79
Cdd:COG4570    32 AYRNLVALAARQQMPKKPLEGPVAVEIKFYfPPDRRKPDLDNLLKAILDALTGAGVWKDDSQVVDLIVEKRYDDKGPRVE 111


                  ....*.
gi 1549067765  80 VKIYEI 85
Cdd:COG4570   112 VEIEEL 117
PRK09786 PRK09786
endodeoxyribonuclease RUS; Reviewed
 1-87 2.78e-25

endodeoxyribonuclease RUS; Reviewed


Pssm-ID: 182075  Cd Length: 120  Bit Score: 90.70  E-value: 2.78e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549067765   1 RYRRAVALIVRQQRLKLSLSGRLAIKIIAEPPDKRRRDLDNILKAPLDALTHAEVLIDDEQFDEINIVRGQPVPGGRLGV 80
Cdd:PRK09786   33 AYRDNVARIIKNAMLDIGLAMPVKIRIECHMPDRRRRDLDNLQKAAFDALTKAGFWLDDAQVVDYRVVKMPVTKGGRLEL 112


                  ....*..
gi 1549067765  81 KIYEIRG 87
Cdd:PRK09786  113 TITEMGN 119
RusA pfam05866
Endodeoxyribonuclease RusA; This family consists of several bacterial and phage Holliday ...
 1-86 9.79e-10

Endodeoxyribonuclease RusA; This family consists of several bacterial and phage Holliday junction resolvase (RusA) like proteins. The RusA protein of Escherichia coli is an endonuclease that can resolve Holliday intermediates and correct the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC.


Pssm-ID: 428654  Cd Length: 124  Bit Score: 51.13  E-value: 9.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549067765   1 RYRRAVALIVRQQRL-KLSLSGRLAIKIIAEPPDK-----------------RRRDLDNILKAPLDALtHAEVLIDDEQF 62
Cdd:pfam05866  26 AYENLVKLYLAQQMPgRPPLEGPVKVEIKAYFPIPkswskkkralegkirptKKPDIDNLAKALLDAL-NGGVWKDDSQV 104

                          90       100
                  ....*....|....*....|....
gi 1549067765  63 DEINIvrgQPVPGGRLGVKIyEIR 86
Cdd:pfam05866 105 VDIIV---EKFYSEEPRVEV-EIE 124
 
Name Accession Description Interval E-value
RusA COG4570
Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination ...
 1-85 1.86e-26

Holliday junction resolvase RusA (prophage-encoded endonuclease) [Replication, recombination and repair];


Pssm-ID: 443627  Cd Length: 120  Bit Score: 93.80  E-value: 1.86e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549067765   1 RYRRAVALIVRQQRLKLSLSGRLAIKIIAE-PPDKRRRDLDNILKAPLDALTHAEVLIDDEQFDEINIVRGQPVPGGRLG 79
Cdd:COG4570    32 AYRNLVALAARQQMPKKPLEGPVAVEIKFYfPPDRRKPDLDNLLKAILDALTGAGVWKDDSQVVDLIVEKRYDDKGPRVE 111


                  ....*.
gi 1549067765  80 VKIYEI 85
Cdd:COG4570   112 VEIEEL 117
PRK09786 PRK09786
endodeoxyribonuclease RUS; Reviewed
 1-87 2.78e-25

endodeoxyribonuclease RUS; Reviewed


Pssm-ID: 182075  Cd Length: 120  Bit Score: 90.70  E-value: 2.78e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549067765   1 RYRRAVALIVRQQRLKLSLSGRLAIKIIAEPPDKRRRDLDNILKAPLDALTHAEVLIDDEQFDEINIVRGQPVPGGRLGV 80
Cdd:PRK09786   33 AYRDNVARIIKNAMLDIGLAMPVKIRIECHMPDRRRRDLDNLQKAAFDALTKAGFWLDDAQVVDYRVVKMPVTKGGRLEL 112


                  ....*..
gi 1549067765  81 KIYEIRG 87
Cdd:PRK09786  113 TITEMGN 119
RusA pfam05866
Endodeoxyribonuclease RusA; This family consists of several bacterial and phage Holliday ...
 1-86 9.79e-10

Endodeoxyribonuclease RusA; This family consists of several bacterial and phage Holliday junction resolvase (RusA) like proteins. The RusA protein of Escherichia coli is an endonuclease that can resolve Holliday intermediates and correct the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC.


Pssm-ID: 428654  Cd Length: 124  Bit Score: 51.13  E-value: 9.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549067765   1 RYRRAVALIVRQQRL-KLSLSGRLAIKIIAEPPDK-----------------RRRDLDNILKAPLDALtHAEVLIDDEQF 62
Cdd:pfam05866  26 AYENLVKLYLAQQMPgRPPLEGPVKVEIKAYFPIPkswskkkralegkirptKKPDIDNLAKALLDAL-NGGVWKDDSQV 104

                          90       100
                  ....*....|....*....|....
gi 1549067765  63 DEINIvrgQPVPGGRLGVKIyEIR 86
Cdd:pfam05866 105 VDIIV---EKFYSEEPRVEV-EIE 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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