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Conserved domains on  [gi|1549894312|gb|RVL93961|]
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glycosyltransferase family 1 protein [Sinorhizobium meliloti]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 14-379 6.11e-59

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 196.22  E-value: 6.11e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  14 LLEVLEPGGGGSGRHFLDLCRGMHVRGHHVEAIysPVRAEDGFVRELKAlglpaiHAVGMRRAPGPSDWSCLRAIN--RI 91
Cdd:cd03801     5 LSPELPPPVGGAERHVRELARALAARGHDVTVL--TPADPGEPPEELED------GVIVPLLPSLAALLRARRLLRelRP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  92 IRTAGPFDVIHGHSSKAGALTRLRLPGRHVPRVYTPHAFRTMDPTLGRGG--RLIYGAIETLlarFFTDHLVAVSGDEFA 169
Cdd:cd03801    77 LLRLRKFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAerRLLARAEALL---RRADAVIAVSEALRD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 170 HALSI-GISGKGMSVIVNGVDTPSPDMAqtVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGS 248
Cdd:cd03801   154 ELRALgGIPPEKIVVIPNGVDLERFSPP--LRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVGG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 249 -GELEEEVRAAIAasGLQNRIHLTSaFTGPQAVPAF----DLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDH 323
Cdd:cd03801   232 dGPLRAELEELEL--GLGDRVRFLG-FVPDEELPALyaaaDVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVED 308

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1549894312 324 GENGYIVPNsEDVSPLARAMI-AAADPE-MFRRLAGAAAARRDRFTLKRMLDETEEVY 379
Cdd:cd03801   309 GEGGLVVPP-DDVEALADALLrLLADPElRARLGRAARERVAERFSWERVAERLLDLY 365
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 14-379 6.11e-59

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 196.22  E-value: 6.11e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  14 LLEVLEPGGGGSGRHFLDLCRGMHVRGHHVEAIysPVRAEDGFVRELKAlglpaiHAVGMRRAPGPSDWSCLRAIN--RI 91
Cdd:cd03801     5 LSPELPPPVGGAERHVRELARALAARGHDVTVL--TPADPGEPPEELED------GVIVPLLPSLAALLRARRLLRelRP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  92 IRTAGPFDVIHGHSSKAGALTRLRLPGRHVPRVYTPHAFRTMDPTLGRGG--RLIYGAIETLlarFFTDHLVAVSGDEFA 169
Cdd:cd03801    77 LLRLRKFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAerRLLARAEALL---RRADAVIAVSEALRD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 170 HALSI-GISGKGMSVIVNGVDTPSPDMAqtVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGS 248
Cdd:cd03801   154 ELRALgGIPPEKIVVIPNGVDLERFSPP--LRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVGG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 249 -GELEEEVRAAIAasGLQNRIHLTSaFTGPQAVPAF----DLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDH 323
Cdd:cd03801   232 dGPLRAELEELEL--GLGDRVRFLG-FVPDEELPALyaaaDVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVED 308

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1549894312 324 GENGYIVPNsEDVSPLARAMI-AAADPE-MFRRLAGAAAARRDRFTLKRMLDETEEVY 379
Cdd:cd03801   309 GEGGLVVPP-DDVEALADALLrLLADPElRARLGRAARERVAERFSWERVAERLLDLY 365
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
209-345 2.34e-25

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 100.28  E-value: 2.34e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 209 AFVFGFIGRLSA-QKAPERLLNAFGKAASAVRNSHVVMVGSGElEEEVRAAIAasGLQNRIHltsaFTG-----PQAVPA 282
Cdd:pfam13692   1 RPVILFVGRLHPnVKGVDYLLEAVPLLRKRDNDVRLVIVGDGP-EEELEELAA--GLEDRVI----FTGfvedlAELLAA 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1549894312 283 FDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVdHGENGYIVPNsEDVSPLARAMIA 345
Cdd:pfam13692  74 ADVFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPELV-DGENGLLVPP-GDPEALAEAILR 134
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 282-379 1.87e-17

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 78.11  E-value: 1.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 282 AFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGENGYIVPnSEDVSPLARAMI-AAADPEMFRRLAGAA- 359
Cdd:COG0438    20 AADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVP-PGDPEALAEAILrLLEDPELRRRLGEAAr 98

                          90       100
                  ....*....|....*....|
gi 1549894312 360 AARRDRFTLKRMLDETEEVY 379
Cdd:COG0438    99 ERAEERFSWEAIAERLLALY 118
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
181-328 7.23e-12

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 66.35  E-value: 7.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 181 MSVIVNGVD--TPSPDMAQTVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVG---------SG 249
Cdd:PRK15484  163 ISIVPNGFCleTYQSNPQPNLRQQLNISPDETVLLYAGRISPDKGILLLMQAFEKLATAHSNLKLVVVGdptasskgeKA 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 250 ELEEEVRAaiAASGLQNRIHLTSAfTGPQAVPAF----DLLVMPSRY-EAMSYVMLEAAAAGRPIIISDVGGAGTAVDHG 324
Cdd:PRK15484  243 AYQKKVLE--AAKRIGDRCIMLGG-QPPEKMHNYyplaDLVVVPSQVeEAFCMVAVEAMAAGKPVLASTKGGITEFVLEG 319


                  ....
gi 1549894312 325 ENGY 328
Cdd:PRK15484  320 ITGY 323
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 183-315 1.93e-05

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 46.46  E-value: 1.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 183 VIVNGVDTPSPDMAQTVRASfGIPAdafVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGSGELE----EEVRAA 258
Cdd:NF038011  284 VIPNGIDLPRLAPLRAQRPA-GIPP---VVGLIGRVVPIKDIKTFIRAMRTVVRAMPEAEGWIVGPEEEDpayaAECRSL 359

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1549894312 259 IAASGLQNRIHltsaFTGPQAV----PAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVG 315
Cdd:NF038011  360 VASLGLQDKVK----FLGFQKIddllPQVGLMVLSSISEALPLVVLEAFAAGVPVVTTDVG 416
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 14-379 6.11e-59

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 196.22  E-value: 6.11e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  14 LLEVLEPGGGGSGRHFLDLCRGMHVRGHHVEAIysPVRAEDGFVRELKAlglpaiHAVGMRRAPGPSDWSCLRAIN--RI 91
Cdd:cd03801     5 LSPELPPPVGGAERHVRELARALAARGHDVTVL--TPADPGEPPEELED------GVIVPLLPSLAALLRARRLLRelRP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  92 IRTAGPFDVIHGHSSKAGALTRLRLPGRHVPRVYTPHAFRTMDPTLGRGG--RLIYGAIETLlarFFTDHLVAVSGDEFA 169
Cdd:cd03801    77 LLRLRKFDVVHAHGLLAALLAALLALLLGAPLVVTLHGAEPGRLLLLLAAerRLLARAEALL---RRADAVIAVSEALRD 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 170 HALSI-GISGKGMSVIVNGVDTPSPDMAqtVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGS 248
Cdd:cd03801   154 ELRALgGIPPEKIVVIPNGVDLERFSPP--LRRKLGIPPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVGG 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 249 -GELEEEVRAAIAasGLQNRIHLTSaFTGPQAVPAF----DLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDH 323
Cdd:cd03801   232 dGPLRAELEELEL--GLGDRVRFLG-FVPDEELPALyaaaDVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVED 308

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1549894312 324 GENGYIVPNsEDVSPLARAMI-AAADPE-MFRRLAGAAAARRDRFTLKRMLDETEEVY 379
Cdd:cd03801   309 GEGGLVVPP-DDVEALADALLrLLADPElRARLGRAARERVAERFSWERVAERLLDLY 365
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 23-351 1.32e-56

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 190.11  E-value: 1.32e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  23 GGSGRHFLDLCRGMHVRGHHVEAIYSPVRAEDgfvRELKALGLPAIHAVGMRRAPGP-SDWSCLRAINRIIRTAGPfDVI 101
Cdd:cd03808    10 GGFQSFRLPLIKALVKKGYEVHVIAPDGDKLS---DELKELGVKVIDIPILRRGINPlKDLKALFKLYKLLKKEKP-DIV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 102 HGHSSKAGALTRL--RLPGRHvPRVYTPHAFRTMDpTLGRGGRLIYGAIETLLARFfTDHLVAVSGDEFAHALSIGISGK 179
Cdd:cd03808    86 HCHTPKPGILGRLaaRLAGVP-KVIYTVHGLGFVF-TEGKLLRLLYLLLEKLALLF-TDKVIFVNEDDRDLAIKKGIIKK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 180 GMSVIVNGVdtpSPDMAQTVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGSGELEEEVRAAI 259
Cdd:cd03808   163 KKTVLIPGS---GVDLDRFQYSPESLPSEKVVFLFVARLLKDKGIDELIEAAKILKKKGPNVRFLLVGDGELENPSEILI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 260 AASGLQNRIHltsaFTGP-QAVPAF----DLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGENGYIVPnSE 334
Cdd:cd03808   240 EKLGLEGRIE----FLGFrSDVPELlaesDVFVLPSYREGLPRSLLEAMAAGRPVITTDVPGCRELVIDGVNGFLVP-PG 314

                         330
                  ....*....|....*...
gi 1549894312 335 DVSPLARAMIAAA-DPEM 351
Cdd:cd03808   315 DVEALADAIEKLIeDPEL 332
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 21-349 2.38e-46

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 162.91  E-value: 2.38e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  21 GGGGSGRHFLDLCRGMHVRGHHVE-AIYSPVRAEDGFVRELKALGLPAIHAVgmrRAPGPSDWSCLRAINRIIRTAgPFD 99
Cdd:cd03811    10 SGGGAERVLLNLANALDKRGYDVTlVLLRDEGDLDKQLNGDVKLIRLLIRVL---KLIKLGLLKAILKLKRILKRA-KPD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 100 VIHGHSSKAGALTRLrLPGRHVPRVYTPHafrtMDPTLGRGGRLIYGAIETLLARFftDHLVAVSGD--EFAHALSiGIS 177
Cdd:cd03811    86 VVISFLGFATYIVAK-LAAARSKVIAWIH----SSLSKLYYLKKKLLLKLKLYKKA--DKIVCVSKGikEDLIRLG-PSP 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 178 GKGMSVIVNGVDTPSPDMaQTVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGSGELEEEVRA 257
Cdd:cd03811   158 PEKIEVIYNPIDIDRIRA-LAKEPILNEPEDGPVILAVGRLDPQKGHDLLIEAFAKLRKKYPDVKLVILGDGPLREELEK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 258 AIAASGLQNRIHltsaFTGPQAVP-----AFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGENGYIVPN 332
Cdd:cd03811   237 LAKELGLAERVI----FLGFQSNPypylkKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREILDDGENGLLVPD 312

                         330
                  ....*....|....*..
gi 1549894312 333 SeDVSPLARAMIAAADP 349
Cdd:cd03811   313 G-DAAALAGILAALLQK 328
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 23-379 1.63e-43

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 155.55  E-value: 1.63e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  23 GGSGRHFLDLCRGMHVRGHHVEAIYspVRAEDGFVRELKALGLPaIHAVGMRraPGPSDWSCLRAInRIIRTAGPfDVIH 102
Cdd:cd03807    12 GGAETMLLRLLEHMDKSRFEHVVIS--LTGDGVLGEELLAAGVP-VVCLGLS--SGKDPGVLLRLA-KLIRKRNP-DVVH 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 103 GHSSKAGALTRLRLPGRHVPRVYtpHAFRTMDpTLGRGGRLIYgAIETLLARFFTDhLVAVSGDEFAHALSIGISGKGMS 182
Cdd:cd03807    85 TWMYHADLIGGLAAKLAGGVKVI--WSVRSSN-IPQRLTRLVR-KLCLLLSKFSPA-TVANSSAVAEFHQEQGYAKNKIV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 183 VIVNGVD----TPSPDMAQTVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGSGELEEEVRAA 258
Cdd:cd03807   160 VIYNGIDlfklSPDDASRARARRRLGLAEDRRVIGIVGRLHPVKDHSDLLRAAALLVETHPDLRLLLVGRGPERPNLERL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 259 IAASGLQNRIHltsaFTG-----PQAVPAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGeNGYIVPNs 333
Cdd:cd03807   240 LLELGLEDRVH----LLGersdvPALLPAMDIFVLSSRTEGFPNALLEAMACGLPVVATDVGGAAELVDDG-TGFLVPA- 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1549894312 334 EDVSPLARAMIAAAD--PEMFRRLAGAAAARRDRFTLKRMLDETEEVY 379
Cdd:cd03807   314 GDPQALADAIRALLEdpEKRARLGRAARERIANEFSIDAMVRRYETLY 361
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 12-348 2.43e-40

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 146.73  E-value: 2.43e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  12 LRLLEVLEPGGGGsgRHFLDLCRGMHVRGHHVeaiyspVRAEDGF--VRELKALGLPaihaVGMRRAPGPSDWSCLRAIN 89
Cdd:cd03819     2 LMLTPALEIGGAE--TYILDLARALAERGHRV------LVVTAGGplLPRLRQIGIG----LPGLKVPLLRALLGNVRLA 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  90 RIIRTAGPfDVIHGHSSKAGALTRLRLPGRHVPRVYTPH--AFRTMDPTLGRggrliygaietLLARFFTDHLVAVSGDE 167
Cdd:cd03819    70 RLIRRERI-DLIHAHSRAPAWLGWLASRLTGVPLVTTVHgsYLATYHPKDFA-----------LAVRARGDRVIAVSELV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 168 FAHAL-SIGISGKGMSVIVNGVDTPSPDMAQTV--RASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAAsAVRNSHVV 244
Cdd:cd03819   138 RDHLIeALGVDPERIRVIPNGVDTDRFPPEAEAeeRAQLGLPEGKPVVGYVGRLSPEKGWLLLVDAAAELK-DEPDFRLL 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 245 MVGSGELEEEVRAAIAASGLQNRIHltsaFTGP-QAVPAF----DLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGT 319
Cdd:cd03819   217 VAGDGPERDEIRRLVERLGLRDRVT----FTGFrEDVPAAlaasDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGARE 292

                         330       340
                  ....*....|....*....|....*....
gi 1549894312 320 AVDHGENGYIVPNsEDVSPLARAMIAAAD 348
Cdd:cd03819   293 IVVHGRTGLLVPP-GDAEALADAIRAAKL 320
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 23-350 6.40e-33

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 127.11  E-value: 6.40e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  23 GGSGRHFLDLCRGMHVRGH--HVEAIYSPVRAEDGFVRELKALGLP---AIHAVGMRRAPGPSDWSCLRAINRII--RTA 95
Cdd:cd03798    14 PGRGIFVRRQVRALSRRGVdvEVLAPAPWGPAAARLLRKLLGEAVPprdGRRLLPLKPRLRLLAPLRAPSLAKLLkrRRR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  96 GPFDVIHGH-SSKAGALTRL--RLPGrhVPRVYTPHAFRTMDPTLGRGGRLIYGAIetlLARFftDHLVAVSGDEFAHAL 172
Cdd:cd03798    94 GPPDLIHAHfAYPAGFAAALlaRLYG--VPYVVTEHGSDINVFPPRSLLRKLLRWA---LRRA--ARVIAVSKALAEELV 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 173 SIGISGKGMSVIVNGVDtpsPDMAQTVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGSGELE 252
Cdd:cd03798   167 ALGVPRDRVDVIPNGVD---PARFQPEDRGLGLPLDAFVILFVGRLIPRKGIDLLLEAFARLAKARPDVVLLIVGDGPLR 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 253 EEVRAAIAASGLQNRIHLTSAFTgPQAVPAF----DLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGENGY 328
Cdd:cd03798   244 EALRALAEDLGLGDRVTFTGRLP-HEQVPAYyracDVFVLPSRHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETGL 322

                         330       340
                  ....*....|....*....|..
gi 1549894312 329 IVPnSEDVSPLARAMIAAADPE 350
Cdd:cd03798   323 LVP-PGDADALAAALRRALAEP 343
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 85-314 1.39e-26

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 109.30  E-value: 1.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  85 LRAINRIIRtAGPFDVIHGHSSKAGALTRLRLPGRHVP-RVYTPHAFRTMDptlGRGGRLIYGAIETLLARFFTDHLvAV 163
Cdd:cd03812    69 FIKLLKLIK-KEKYDIVHVHGSSSNGIILLLAAKAGVPvRIAHSHNTKDSS---IKLRKIRKNVLKKLIERLSTKYL-AC 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 164 SgDEFAHALSIGISGKGMSVIVNGVD----TPSPDMAQTVRASfGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVR 239
Cdd:cd03812   144 S-EDAGEWLFGEVENGKFKVIPNGIDiekyKFNKEKRRKRRKL-LILEDKLVLGHVGRFNEQKNHSFLIDIFEELKKKNP 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 240 NSHVVMVGSGELEEEVRAAIAASGLQNRIHltsaFTG-----PQAVPAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDV 314
Cdd:cd03812   222 NVKLVLVGEGELKEKIKEKVKELGLEDKVI----FLGfrndvSEILSAMDVFLFPSLYEGLPLVAVEAQASGLPCLLSDT 297
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 19-331 4.00e-26

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 108.87  E-value: 4.00e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  19 EPGG---GGSGRHFLDLCRGMHVRGHHVEAIYSPVRAEDGFVRELkalglpAIHAVGMRRAPGPSD-------WSCLRA- 87
Cdd:cd03800    14 QPGGadtGGQNVYVLELARALAELGYQVDIFTRRISPADPEVVEI------APGARVIRVPAGPPEylpkeelWPYLEEf 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  88 ----INRIIRTAGPFDVIHGH---SSKAGALTRLRLpgrHVPRVYTPHAF-RTMDPTLGRGGR----LIYGAIETLLARf 155
Cdd:cd03800    88 adglLRFIAREGGRYDLIHSHywdSGLVGALLARRL---GVPLVHTFHSLgRVKYRHLGAQDTyhpsLRITAEEQILEA- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 156 fTDHLVAVSGDEFAHALS-IGISGKGMSVIVNGVDT----PSPDmAQTVRASFGIPADAFVFGFIGRLSAQKAPERLLNA 230
Cdd:cd03800   164 -ADRVIASTPQEADELISlYGADPSRINVVPPGVDLerffPVDR-AEARRARLLLPPDKPVVLALGRLDPRKGIDTLVRA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 231 FGKAASAVRNSHVVMVG-----SGELEEEVRAAIAAS-GLQNRIHlTSAFTGPQAVPAF----DLLVMPSRYEAMSYVML 300
Cdd:cd03800   242 FAQLPELRELANLVLVGgpsddPLSMDREELAELAEElGLIDRVR-FPGRVSRDDLPELyraaDVFVVPSLYEPFGLTAI 320

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1549894312 301 EAAAAGRPIIISDVGGAGTAVDHGENGYIVP 331
Cdd:cd03800   321 EAMACGTPVVATAVGGLQDIVRDGRTGLLVD 351
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
209-345 2.34e-25

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 100.28  E-value: 2.34e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 209 AFVFGFIGRLSA-QKAPERLLNAFGKAASAVRNSHVVMVGSGElEEEVRAAIAasGLQNRIHltsaFTG-----PQAVPA 282
Cdd:pfam13692   1 RPVILFVGRLHPnVKGVDYLLEAVPLLRKRDNDVRLVIVGDGP-EEELEELAA--GLEDRVI----FTGfvedlAELLAA 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1549894312 283 FDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVdHGENGYIVPNsEDVSPLARAMIA 345
Cdd:pfam13692  74 ADVFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPELV-DGENGLLVPP-GDPEALAEAILR 134
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 208-351 1.11e-24

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 98.89  E-value: 1.11e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 208 DAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGSGELEEEVRAAIAASGLQNRIHLTSaFTGPQAVPAF---- 283
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLG-FVSDEDLPELlkia 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1549894312 284 DLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGENGYIVPNsEDVSPLARAMIAA-ADPEM 351
Cdd:pfam00534  80 DVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKP-NNAEALAEAIDKLlEDEEL 147
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 32-344 3.93e-24

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 102.74  E-value: 3.93e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  32 LCRGMHVRGHHVEAIYSPV----RAEDGFVRELKALGLPAIHAVGMRRAPGPsdwsclrAINRIIRTAGPfDVIHGHSSK 107
Cdd:cd03817    23 LARALEKRGHEVYVITPSDpgaeDEEEVVRYRSFSIPIRKYHRQHIPFPFKK-------AVIDRIKELGP-DIIHTHTPF 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 108 AGALTRLRLPGR-HVPRVYTPHafrTMDP------TLGRGGRLIYgaIETLLARF--FTDHLVAVSGDEFAHALSIGISG 178
Cdd:cd03817    95 SLGKLGLRIARKlKIPIVHTYH---TMYEdylhyiPKGKLLVKAV--VRKLVRRFynHTDAVIAPSEKIKDTLREYGVKG 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 179 KgMSVIVNGVDT----PSPDMAQtvRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVrNSHVVMVGSGELEEE 254
Cdd:cd03817   170 P-IEVIPNGIDLdkfeKPLNTEE--RRKLGLPPDEPILLYVGRLAKEKNIDFLLRAFAELKKEP-NIKLVIVGDGPEREE 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 255 VRAAIAASGLQNRIHltsaFTG---PQAVPAF----DLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGENG 327
Cdd:cd03817   246 LKELARELGLADKVI----FTGfvpREELPEYykaaDLFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASELVEDGENG 321

                         330
                  ....*....|....*..
gi 1549894312 328 YIVPNSEDvsPLARAMI 344
Cdd:cd03817   322 FLFEPNDE--TLAEKLL 336
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 12-346 4.13e-24

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 102.83  E-value: 4.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  12 LRLLEVLEPGGGGSGRHFLDLCRGMHVRGHHVEaIYSPVRAEDGFVRELKALGLPAI---HAVGMRRaPGPSDWS-CLRA 87
Cdd:cd03821     3 LHVTPSISPKAGGPVKVVLRLAAALAALGHEVT-IVSTGDGYESLVVEENGRYIPPQdgfASIPLLR-QGAGRTDfSPGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  88 INRIIRTAGPFDVIHGH------SSKAGALTRlrlpGRHVPRVYTPHafrTMDPTLGRGGRLIYGAIETL------LARF 155
Cdd:cd03821    81 PNWLRRNLREYDVVHIHgvwtytSLAACKLAR----RRGIPYVVSPH---GMLDPWALQQKHWKKRIALHlierrnLNNA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 156 FTDHLVAVsgDEFAHALSIGISGKgMSVIVNGVDTPSPDMAQTVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAA 235
Cdd:cd03821   154 ALVHFTSE--QEADELRRFGLEPP-IAVIPNGVDIPEFDPGLRDRRKHNGLEDRRIILFLGRIHPKKGLDLLIRAARKLA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 236 SAVRNSHVVMVGSGELEEEVRAA-IAASGLQNRIHLTSAFTG---PQAVPAFDLLVMPSRYEAMSYVMLEAAAAGRPIII 311
Cdd:cd03821   231 EQGRDWHLVIAGPDDGAYPAFLQlQSSLGLGDRVTFTGPLYGeakWALYASADLFVLPSYSENFGNVVAEALACGLPVVI 310

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1549894312 312 SD-VGGAGtAVDHGeNGYIVpnSEDVSPLARAMIAA 346
Cdd:cd03821   311 TDkCGLSE-LVEAG-CGVVV--DPNVSSLAEALAEA 342
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 22-351 1.10e-23

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 101.25  E-value: 1.10e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  22 GGGSGRHFLDLCRGMHVRGHHVEAIY-----SPVRAEDGFVRELKALGLPAIHAVGMRRAPGPS--DWSCLRAI-NRIIR 93
Cdd:cd03823    14 VGGAEISVHDLAEALVAEGHEVAVLTagvgpPGQATVARSVVRYRRAPDETLPLALKRRGYELFetYNPGLRRLlARLLE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  94 TAGPfDVIHGHSSK---AGALTRLRLpgRHVPRVYTPHAFRTMDPtlgrGGRLIYGAIETLLA--RFFTDHLVAVsgdef 168
Cdd:cd03823    94 DFRP-DVVHTHNLSglgASLLDAARD--LGIPVVHTLHDYWLLCP----RQFLFKKGGDAVLApsRFTANLHEAN----- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 169 ahalsiGISGKGMSVIVNGVDTPSPDMAQTVRASfgipaDAFVFGFIGRLSAQKAPERLLNAFGKAASavRNSHVVMVGS 248
Cdd:cd03823   162 ------GLFSARISVIPNAVEPDLAPPPRRRPGT-----ERLRFGYIGRLTEEKGIDLLVEAFKRLPR--EDIELVIAGH 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 249 GELEEEVRAAIAAsglqnRIHLTSAFTgPQAVPAF----DLLVMPSR-YEAMSYVMLEAAAAGRPIIISDVGGAGTAVDH 323
Cdd:cd03823   229 GPLSDERQIEGGR-----RIAFLGRVP-TDDIKDFyekiDVLVVPSIwPEPFGLVVREAIAAGLPVIASDLGGIAELIQP 302

                         330       340
                  ....*....|....*....|....*...
gi 1549894312 324 GENGYIVPnSEDVSPLARAMIAAADPEM 351
Cdd:cd03823   303 GVNGLLFA-PGDAEDLAAAMRRLLTDPA 329
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 181-350 2.34e-22

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 97.31  E-value: 2.34e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 181 MSVIVNGVDTPSPDMAQtvrasfgiPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGSGELEEEVRAAIA 260
Cdd:cd03820   161 VVVIPNPLSFPSEEPST--------NLKSKRILAVGRLTYQKGFDLLIEAWALIAKKHPDWKLRIYGDGPEREELEKLID 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 261 ASGLQNRIHLTSAFTGPQAV-PAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISD-VGGAGTAVDHGENGYIVPNsEDVSP 338
Cdd:cd03820   233 KLGLEDRVKLLGPTKNIAEEyANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFDcPTGPSEIIEDGENGLLVPN-GDVDA 311

                         170
                  ....*....|...
gi 1549894312 339 LARAMIA-AADPE 350
Cdd:cd03820   312 LAEALLRlMEDEE 324
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 21-379 2.57e-22

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 97.13  E-value: 2.57e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  21 GGGGSGRHFLDLCRGMHVRGHHVEAIYSpvraeDGFVRELKALGLPAIHAVGMRRAPgpsdWSCLRAINR---IIRTAGP 97
Cdd:cd04951    10 GLGGAEKQTVLLADQMFIRGHDVNIVYL-----TGEVEVKPLNNNIIIYNLGMDKNP----RSLLKALLKlkkIISAFKP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  98 fDVIHGHSSKAGALTRL-RLPGRHVPRVYTPHAfrtmdptlgrggRLIYGAIETLLARFfTDHLVAVSGDEFAHALSIGI 176
Cdd:cd04951    81 -DVVHSHMFHANIFARFlRMLYPIPLLICTAHN------------KNEGGRIRMFIYRL-TDFLCDITTNVSREALDEFI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 177 SGKGMS-----VIVNGVDTP----SPDMAQTVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVG 247
Cdd:cd04951   147 AKKAFSknksvPVYNGIDLNkfkkDINVRLKIRNKLNLKNDEFVILNVGRLTEAKDYPNLLLAISELILSKNDFKLLIAG 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 248 SGELEEEVRAAIAASGLQNRIHLTSAFTG-PQAVPAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGEn 326
Cdd:cd04951   227 DGPLRNELERLICNLNLVDRVILLGQISNiSEYYNAADLFVLSSEWEGFGLVVAEAMACERPVVATDAGGVAEVVGDHN- 305

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1549894312 327 gYIVPNSeDVSPLARAM--IAAADPEMFRRLAGAAAARRDRFTLKRMLDETEEVY 379
Cdd:cd04951   306 -YVVPVS-DPQLLAEKIkeIFDMSDEERDILGNKNEYIAKNFSINTIVNEWERLY 358
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 214-330 5.76e-21

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 90.93  E-value: 5.76e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 214 FIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGSGELEEEVRAAIAASGLQNRIHLTSAFTGPQAVPAF----DLLVMP 289
Cdd:cd01635   115 SVGRLVPEKGIDLLLEALALLKARLPDLVLVLVGGGGEREEEEALAAALGLLERVVIIGGLVDDEVLELLlaaaDVFVLP 194

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1549894312 290 SRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGENGYIV 330
Cdd:cd01635   195 SRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 21-377 3.46e-19

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 88.19  E-value: 3.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  21 GGGGSGRHFLDLCRGMHVRGHHVeaIYSPVRAEDGFVRELKALGLPAIHAVGMRRAPGPSDWscLRAINRIIRTAGPFDV 100
Cdd:cd03809    12 RLTGIGRYTRELLKALAKNDPDE--SVLAVPPLPGELLRLLREYPELSLGVIKIKLWRELAL--LRWLQILLPKKDKPDL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 101 IHGHSSkagaltRLRLPGRHVPRVYTPH--AFRTMDPTLGRGGRLIYGAIETLLARFfTDHLVAVSgdEF-AHALS--IG 175
Cdd:cd03809    88 LHSPHN------TAPLLLKGCPQVVTIHdlIPLRYPEFFPKRFRLYYRLLLPISLRR-ADAIITVS--EAtRDDIIkfYG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 176 ISGKGMSVIVNGVDT-PSPDMAQTVRASFGIPADAFVFgFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGSGELE-E 253
Cdd:cd03809   159 VPPEKIVVIPLGVDPsFFPPESAAVLIAKYLLPEPYFL-YVGTLEPRKNHERLLKAFALLKKQGGDLKLVIVGGKGWEdE 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 254 EVRAAIAASGLQNRIHltsaFTG--PQA-VPAF----DLLVMPSRYEAMSYVMLEAAAAGRPIIISD-------VGGAGT 319
Cdd:cd03809   238 ELLDLVKKLGLGGRVR----FLGyvSDEdLPALyrgaRAFVFPSLYEGFGLPVLEAMACGTPVIASNisvlpevAGDAAL 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1549894312 320 AVDhgengyivpnSEDVSPLARAMIAAA-DPEMFRRLAGAAAARRDRFTLKRMLDETEE 377
Cdd:cd03809   314 YFD----------PLDPESIADAILRLLeDPSLREELIRKGLERAKKFSWEKTAEKTLE 362
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 177-343 4.63e-18

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 85.08  E-value: 4.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 177 SGKGMSVIVNGVDTP--SPDMAQTVRASFGIPADAFVFGFIgrlsAQKAPER-----LLNAFGKAASAVRNSHVVMVGSG 249
Cdd:cd03825   159 KGLPVVVIPNGIDTEifAPVDKAKARKRLGIPQDKKVILFG----AESVTKPrkgfdELIEALKLLATKDDLLLVVFGKN 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 250 ElEEEVRAAIAASGL---QNRIHLTSAFTgpqavpAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGEN 326
Cdd:cd03825   235 D-PQIVILPFDIISLgyiDDDEQLVDIYS------AADLFVHPSLADNLPNTLLEAMACGTPVVAFDTGGSPEIVQHGVT 307

                         170
                  ....*....|....*..
gi 1549894312 327 GYIVPNsEDVSPLARAM 343
Cdd:cd03825   308 GYLVPP-GDVQALAEAI 323
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 282-379 1.87e-17

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 78.11  E-value: 1.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 282 AFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGENGYIVPnSEDVSPLARAMI-AAADPEMFRRLAGAA- 359
Cdd:COG0438    20 AADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVP-PGDPEALAEAILrLLEDPELRRRLGEAAr 98

                          90       100
                  ....*....|....*....|
gi 1549894312 360 AARRDRFTLKRMLDETEEVY 379
Cdd:COG0438    99 ERAEERFSWEAIAERLLALY 118
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 20-350 2.05e-16

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 80.46  E-value: 2.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  20 PGGGGSGRHFLDLCRGMHVRGHHVEAIYSPVRAEDGFVRELKALG----------LPAIHAVGMRRAPGPSDWSCLRAIN 89
Cdd:cd03794    11 PPKGAAAARVYELAKELVRRGHEVTVLTPSPNYPLGRIFAGATETkdgirvirvkLGPIKKNGLIRRLLNYLSFALAALL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  90 RIIRTAGPFDVIHGHSS-----KAGALTRLRlpgRHVPRVYTPHafrtmDP---TLGRGGRLIYGAIETLLARFF----- 156
Cdd:cd03794    91 KLLVREERPDVIIAYSPpitlgLAALLLKKL---RGAPFILDVR-----DLwpeSLIALGVLKKGSLLKLLKKLErklyr 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 157 -TDHLVAVSGDEFAHALSIGISGKGMSVIVNGVDTPSPD-MAQTVRASFGIPADAFVFGFIGRL-SAQkAPERLLNAFGK 233
Cdd:cd03794   163 lADAIIVLSPGLKEYLLRKGVPKEKIIVIPNWADLEEFKpPPKDELRKKLGLDDKFVVVYAGNIgKAQ-GLETLLEAAER 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 234 AASaVRNSHVVMVGSGELEEEVRAAIAASGLQNRIHLtsAFTGPQAVPAF----DLLVMPSRYEAMSYV-----MLEAAA 304
Cdd:cd03794   242 LKR-RPDIRFLFVGDGDEKERLKELAKARGLDNVTFL--GRVPKEEVPELlsaaDVGLVPLKDNPANRGsspskLFEYMA 318

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1549894312 305 AGRPIIISDVGGAGTAVDHGENGYIVPNsEDVSPLARAMIAAADPE 350
Cdd:cd03794   319 AGKPILASDDGGSDLAVEINGCGLVVEP-GDPEALADAILELLDDP 363
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
23-190 2.48e-16

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 76.03  E-value: 2.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  23 GGSGRHFLDLCRGMHVRGHHVEAIyspVRAEDGFVRELKALGLPAIHAVGMRRAPGPSDWSCLRAINRIIRTAGPfDVIH 102
Cdd:pfam13439   1 GGVERYVLELARALARRGHEVTVV---TPGGPGPLAEEVVRVVRVPRVPLPLPPRLLRSLAFLRRLRRLLRRERP-DVVH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 103 GHSSKAGALTRLRLP-GRHVPRVYTPHAFRTMDPTLGRGGRLIYGAIETLLARFF--TDHLVAVSGDEFAHALS-IGISG 178
Cdd:pfam13439  77 AHSPFPLGLAALAARlRLGIPLVVTYHGLFPDYKRLGARLSPLRRLLRRLERRLLrrADRVIAVSEAVADELRRlYGVPP 156

                         170
                  ....*....|..
gi 1549894312 179 KGMSVIVNGVDT 190
Cdd:pfam13439 157 EKIRVIPNGVDL 168
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 20-350 2.53e-16

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 79.65  E-value: 2.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  20 PGGGGSGRHFLDLCRGMHVRGHHVEaIYSPvraeDGFVRELKALGlpAIHAVGMRRAPGPSD----WSCLRAINRIIRTA 95
Cdd:cd03814    11 PQVNGVVRTLERLVDHLRRRGHEVR-VVAP----GPFDEAESAEG--RVVSVPSFPLPFYPEyrlaLPLPRRVRRLIKEF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  96 GPfDVIH-------GHsskAGALTRLRLpgrHVPRVYTPH-------AFRTMDPTLG---RGGRLIYGAIETLLARfftd 158
Cdd:cd03814    84 QP-DIIHiatpgplGL---AALRAARRL---GLPVVTSYHtdfpeylSYYTLGPLSWlawAYLRWFHNPFDTTLVP---- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 159 hlvavSGDEFAHALSIGISGkgMSVIVNGVDTP--SPDMA-QTVRASFGIPaDAFVFGFIGRLSAQKAPERLLNAFGKAA 235
Cdd:cd03814   153 -----SPSIARELEGHGFER--VRLWPRGVDTElfHPSRRdAALRRRLGPP-GRPLLLYVGRLAPEKNLEALLDADLPLA 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 236 SAVRnSHVVMVGSGELeeevRAAIAASGLQnrIHLTSAFTGP---QAVPAFDLLVMPSRYEAMSYVMLEAAAAGRPIIIS 312
Cdd:cd03814   225 ASPP-VRLVVVGDGPA----RAELEARGPD--VIFTGFLTGEelaRAYASADVFVFPSRTETFGLVVLEAMASGLPVVAA 297

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1549894312 313 DVGGAGTAVDHGENGYIVP--NSEDVSPLARAMiaAADPE 350
Cdd:cd03814   298 DAGGPRDIVRPGGTGALVEpgDAAAFAAALRAL--LEDPE 335
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 99-379 2.92e-15

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 77.38  E-value: 2.92e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  99 DVIHGHS----SKAGALTRLRlpgRHVPRVYTPHAFRTMDPTLG-RGGRLIYGAIETLLARFFtDHL---------VAVS 164
Cdd:cd03813   175 DLYHSVStgyaGLLGALARHR---RGIPFLLTEHGIYTRERKIEiLQSTWIMGYIKKLWIRFF-ERLgklayqqadKIIS 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 165 GDEFAHALSI--GISGKGMSVIVNGVDTPSPDMAQTVRAsfgiPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSH 242
Cdd:cd03813   251 LYEGNRRRQIrlGADPDKTRVIPNGIDIQRFAPAREERP----EKEPPVVGLVGRVVPIKDVKTFIRAFKLVRRAMPDAE 326

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 243 VVMVGsGELEEEVRAA-----IAASGLQNRIhltsAFTGPQ----AVPAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISD 313
Cdd:cd03813   327 GWLIG-PEDEDPEYAQeckrlVASLGLENKV----KFLGFQnikeYYPKLGLLVLTSISEGQPLVILEAMASGVPVVATD 401

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1549894312 314 VGGA-----GTAVDHGENGYIVPnSEDVSPLARAMIAA-ADPE-MFRRLAGAAAARRDRFTLKRMLDETEEVY 379
Cdd:cd03813   402 VGSCreliyGADDALGQAGLVVP-PADPEALAEALIKLlRDPElRQAFGEAGRKRVEKYYTLEGMIDSYRKLY 473
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 210-343 6.82e-15

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 75.39  E-value: 6.82e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 210 FVFgFIGRLSAQKAPERLLNAfgkaaSAVRNSHVVMVGSGELEEEVRAAIAAsGLQNRIHLTSAFTGPQAV---PAFDLL 286
Cdd:cd03795   193 IFL-FIGRLVYYKGLDYLIEA-----AQYLNYPIVIGGEGPLKPDLEAQIEL-NLLDNVKFLGRVDDEEKViylHLCDVF 265

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 287 VMPS--RYEAMSYVMLEAAAAGRPIIISDVGGAGTAVD-HGENGYIVPNsEDVSPLARAM 343
Cdd:cd03795   266 VFPSvlRSEAFGIVLLEAMMCGKPVISTNIGTGVPYVNnNGETGLVVPP-KDPDALAEAI 324
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 20-379 7.24e-15

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 75.47  E-value: 7.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  20 PGGGGSGRHFLDLCRGMHVRGHHVEAIYS--PVRaedgfvrelkaLGLPA----IHAVGMRRAP----GPSDWSCLRAIN 89
Cdd:cd04962     9 PSYGGSGVVATELGLELAERGHEVHFISSaiPFR-----------LNLYSgnifFHEVEVPNYPlfeyPPYTLALASKIV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  90 RIIRTAGpFDVIHGH----SSKAGALTRlRLPGRHVPRVYTPHAfrtMDPTLGRGGRLIYGAIETLLARffTDHLVAVSG 165
Cdd:cd04962    78 EVAKEHK-LDVLHAHyaipHASCAYLAR-EILGEKIPIVTTLHG---TDITLVGYDPSLQPAVRFSINK--SDRVTAVSS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 166 DEFAHALSIGISGKGMSVIVNGVDTP--SPDMAQTVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVrNSHV 243
Cdd:cd04962   151 SLRQETYELFDVDKDIEVIHNFIDEDvfKRKPAGALKRRLLAPPDEKVVIHVSNFRPVKRIDDVVRVFARVRRKI-PAKL 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 244 VMVGSGELEEEVRAAIAASGLQNRIHLTSAFTGPQAV-PAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVD 322
Cdd:cd04962   230 LLVGDGPERVPAEELARELGVEDRVLFLGKQDDVEELlSIADLFLLPSEKESFGLAALEAMACGVPVVSSNAGGIPEVVK 309

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1549894312 323 HGENGYIVPNSEDVSPLARAMIAAADPEMFRR-LAGAAAARRDRFTLKRMLDETEEVY 379
Cdd:cd04962   310 HGETGFLSDVGDVDAMAKSALSILEDDELYNRmGRAARKRAAERFDPERIVPQYEAYY 367
Glyco_trans_4_4 pfam13579
Glycosyl transferase 4-like domain;
23-187 1.06e-14

Glycosyl transferase 4-like domain;


Pssm-ID: 433325 [Multi-domain]  Cd Length: 158  Bit Score: 71.28  E-value: 1.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  23 GGSGRHFLDLCRGMHVRGHHVEAIyspVRAEDGFVRELKALGLPAIHAVGMRRAPGPSDWSCLRAINRIIRtAGPFDVIH 102
Cdd:pfam13579   1 GGIGVYVLELARALAALGHEVRVV---TPGGPPGRPELVGDGVRVHRLPVPPRPSPLADLAALRRLRRLLR-AERPDVVH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 103 GHSSKAGALTRLRLPGRHVPRVYTPHAFRTmDPTLGRGGRLiYGAIETLLARFFtDHLVAVSGDEFAHALSIGISGKGMS 182
Cdd:pfam13579  77 AHSPTAGLAARLARRRRGVPLVVTVHGLAL-DYGSGWKRRL-ARALERRLLRRA-DAVVVVSEAEAELLRALGVPAARVV 153


                  ....*
gi 1549894312 183 VIVNG 187
Cdd:pfam13579 154 VVPNG 158
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 205-344 1.20e-13

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 71.56  E-value: 1.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 205 IPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGSGELEEEVRAAIAASGLQNRIHLTSAFTGPQAV-PAF 283
Cdd:cd04949   156 HERKSNKIITISRLAPEKQLDHLIEAVAKAVKKVPEITLDIYGYGEEREKLKKLIEELHLEDNVFLKGYHSNLDQEyQDA 235

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1549894312 284 DLLVMPSRYEAMSYVMLEAAAAGRPIIISDVG-GAGTAVDHGENGYIVPNsEDVSPLARAMI 344
Cdd:cd04949   236 YLSLLTSQMEGFGLTLMEAIGHGLPVVSYDVKyGPSELIEDGENGYLIEK-NNIDALADKII 296
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 99-345 4.73e-13

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 69.79  E-value: 4.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  99 DVIHGHSSKAGALTrlrLPGRH---VPRVYTPHAFrtmDPTL-------GRGGRLIYGAIETLLARFfTDHLVAVSGDEF 168
Cdd:cd05844    83 ALVHAHFGRDGVYA---LPLARalgVPLVVTFHGF---DITTsrawlaaSPGWPSQFQRHRRALQRP-AALFVAVSGFIR 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 169 AHALSIGISGKGMSVIVNGVDTpspdmAQTVRASFGIPADAFVFgfIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGS 248
Cdd:cd05844   156 DRLLARGLPAERIHVHYIGIDP-----AKFAPRDPAERAPTILF--VGRLVEKKGCDVLIEAFRRLAARHPTARLVIAGD 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 249 GELEEEVRAAIAASGlqnRIHLTSAFTGPQAVPAFD---LLVMPSRY------EAMSYVMLEAAAAGRPIIISDVGGAGT 319
Cdd:cd05844   229 GPLRPALQALAAALG---RVRFLGALPHAEVQDWMRraeIFCLPSVTaasgdsEGLGIVLLEAAACGVPVVSSRHGGIPE 305

                         250       260
                  ....*....|....*....|....*.
gi 1549894312 320 AVDHGENGYIVPnSEDVSPLARAMIA 345
Cdd:cd05844   306 AILDGETGFLVP-EGDVDALADALQA 330
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
181-328 7.23e-12

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 66.35  E-value: 7.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 181 MSVIVNGVD--TPSPDMAQTVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVG---------SG 249
Cdd:PRK15484  163 ISIVPNGFCleTYQSNPQPNLRQQLNISPDETVLLYAGRISPDKGILLLMQAFEKLATAHSNLKLVVVGdptasskgeKA 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 250 ELEEEVRAaiAASGLQNRIHLTSAfTGPQAVPAF----DLLVMPSRY-EAMSYVMLEAAAAGRPIIISDVGGAGTAVDHG 324
Cdd:PRK15484  243 AYQKKVLE--AAKRIGDRCIMLGG-QPPEKMHNYyplaDLVVVPSQVeEAFCMVAVEAMAAGKPVLASTKGGITEFVLEG 319


                  ....
gi 1549894312 325 ENGY 328
Cdd:PRK15484  320 ITGY 323
PRK15179 PRK15179
Vi polysaccharide biosynthesis protein TviE; Provisional
 97-348 2.13e-11

Vi polysaccharide biosynthesis protein TviE; Provisional


Pssm-ID: 185101 [Multi-domain]  Cd Length: 694  Bit Score: 65.83  E-value: 2.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  97 PFDVIH---GHSSKAGALTRLrLPGrhVPRVYTphAFRTMDPTLGRGG-RLIYGAIETLLARFFTDHLVAVSgDEFAHAL 172
Cdd:PRK15179  400 VPSVVHiwqDGSIFACALAAL-LAG--VPRIVL--SVRTMPPVDRPDRyRVEYDIIYSELLKMRGVALSSNS-QFAAHRY 473

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 173 S--IGISGKGMSVIVNGV-------DTPSPDMAQTVRASfgiPADA-FVFGFIGRLSAQKAPERLLNAFGKAASAVRNSH 242
Cdd:PRK15179  474 AdwLGVDERRIPVVYNGLaplksvqDDACTAMMAQFDAR---TSDArFTVGTVMRVDDNKRPFLWVEAAQRFAASHPKVR 550

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 243 VVMVGSGELEEEVRAAIAASGLQNRIHLT--SAFTGpQAVPAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTA 320
Cdd:PRK15179  551 FIMVGGGPLLESVREFAQRLGMGERILFTglSRRVG-YWLTQFNAFLLLSRFEGLPNVLIEAQFSGVPVVTTLAGGAGEA 629

                         250       260
                  ....*....|....*....|....*....
gi 1549894312 321 VDHGENGYIVPNSEDVSP-LARAMIAAAD 348
Cdd:PRK15179  630 VQEGVTGLTLPADTVTAPdVAEALARIHD 658
GT5_Glycogen_synthase_DULL1-like cd03791
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ...
 184-352 4.15e-10

Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.


Pssm-ID: 340822 [Multi-domain]  Cd Length: 474  Bit Score: 61.43  E-value: 4.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 184 IVNGVDT----PSPD-----------------MAQTVRASFGIP--ADAFVFGFIGRLSAQK-------APERLLNAFGK 233
Cdd:cd03791   246 ILNGIDYdewnPATDklipanysandlegkaeNKAALQKELGLPvdPDAPLFGFVGRLTEQKgvdlildALPELLEEGGQ 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 234 aasavrnshVVMVGSGELEEEVRAAIAASGLQNRIHLTSAFTGPQAVPAF---DLLVMPSRYEAMSYVMLEAAAAGRPII 310
Cdd:cd03791   326 ---------LVVLGSGDPEYEQAFRELAERYPGKVAVVIGFDEALAHRIYagaDFFLMPSRFEPCGLVQMYAMRYGTLPI 396

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1549894312 311 ISDVGG-AGTAVDHGE-----NGYIVpNSEDVSPLARAMIAA----ADPEMF 352
Cdd:cd03791   397 VRRTGGlADTVFDYDPetgegTGFVF-EDYDAEALLAALRRAlalyRNPELW 447
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 17-343 5.03e-10

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 60.38  E-value: 5.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  17 VLEPGGGGSGRHFLDLCRGMHVRGHHVEAIY---SPVRAEdgfvrelkalgLPAIHAVGMRRAPGPSDWS--CLRAINRI 91
Cdd:cd03802    12 VPPGKYGGTELVVSALTEGLVRRGHEVTLFApgdSHTSAP-----------LVAVIPRALRLDPIPQESKlaELLEALEV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  92 IRTAGPFDVIHGHSskaGALTRLRLPGRHVPRVYTPHafrtmdptlgrgGRLIYGAIETLLARFFTdHLVAVSgdefAHA 171
Cdd:cd03802    81 QLRASDFDVIHNHS---YDWLPPFAPLIGTPFVTTLH------------GPSIPPSLAIYAAEPPV-NYVSIS----DAQ 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 172 LSIGISGKGMSVIVNGVDTpspdmaqtvrASFG-IPADAFVFGFIGRLSAQKAPERLLnafgKAASAVrNSHVVMVGSGE 250
Cdd:cd03802   141 RAATPPIDYLTVVHNGLDP----------ADYRfQPDPEDYLAFLGRIAPEKGLEDAI----RVARRA-GLPLKIAGKVR 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 251 LEEEVRAaIAASGLQNRIHLTSAFTGPQAVPAFD----LLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGEN 326
Cdd:cd03802   206 DEDYFYY-LQEPLPGPRIEFIGEVGHDEKQELLGgaraLLFPINWDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGET 284

                         330
                  ....*....|....*..
gi 1549894312 327 GYIVPNSEDvspLARAM 343
Cdd:cd03802   285 GFLVDSVEE---MAEAI 298
GT4_mannosyltransferase-like cd03822
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ...
 89-348 5.34e-10

mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides.


Pssm-ID: 340849 [Multi-domain]  Cd Length: 370  Bit Score: 60.48  E-value: 5.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  89 NRIIRTAGPfDVIH--------GHSSKAGALTRLRLPGRhvPRVYTPHAFRTMdPTLGRGGRLIYGAIETLLARFFTDHl 160
Cdd:cd03822    68 LDHLNFKKP-DVVHiqhefgifGGKYGLYALGLLLHLRI--PVITTLHTVLDL-SDPGKQALKVLFRIATLSERVVVMA- 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 161 vaVSGDEFAHAlSIGISGKGMSVIVNGV-DTPSPDmaQTVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVR 239
Cdd:cd03822   143 --PISRFLLVR-IKLIPAVNIEVIPHGVpEVPQDP--TTALKRLLLPEGKKVILTFGFIGPGKGLEILLEALPELKAEFP 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 240 NSHVVMVGS-------GELEEEVRAAIAASGLQNRIHLTSAFTGPQAVP----AFDLLVMP--SRYEAMSYVMLEAAAAG 306
Cdd:cd03822   218 DVRLVIAGElhpslarYEGERYRKAAIEELGLQDHVDFHNNFLPEEEVPryisAADVVVLPylNTEQSSSGTLSYAIACG 297

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1549894312 307 RPIIISDVGGAGTAVdHGENGYIVPnSEDVSPLARAMIAAAD 348
Cdd:cd03822   298 KPVISTPLRHAEELL-ADGRGVLVP-FDDPSAIAEAILRLLE 337
glgA PRK00654
glycogen synthase GlgA;
99-297 3.42e-09

glycogen synthase GlgA;


Pssm-ID: 234809 [Multi-domain]  Cd Length: 466  Bit Score: 58.59  E-value: 3.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  99 DVIHGHSSKAG---AL--TRLRLPGRHVPRVYTPH--AF-----RTMDPTLGRG-------GRLIYGAIETLLAR-FFTD 158
Cdd:PRK00654  120 DIVHAHDWHTGlipALlkEKYWRGYPDIKTVFTIHnlAYqglfpAEILGELGLPaeafhleGLEFYGQISFLKAGlYYAD 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 159 HLVAVS--------GDEFAHALS---IGISGKgMSVIVNGVDT----PSPD-----------------MAQTVRASFGIP 206
Cdd:PRK00654  200 RVTTVSptyareitTPEFGYGLEgllRARSGK-LSGILNGIDYdiwnPETDpllaanysaddlegkaeNKRALQERFGLP 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 207 -ADAFVFGFIGRLSAQKAPERLLNAFGKAASavRNSHVVMVGSGE--LEEEVRAaiAASGLQNRIHLTSAFTGPQA---V 280
Cdd:PRK00654  279 dDDAPLFAMVSRLTEQKGLDLVLEALPELLE--QGGQLVLLGTGDpeLEEAFRA--LAARYPGKVGVQIGYDEALAhriY 354

                         250       260
                  ....*....|....*....|....*
gi 1549894312 281 PAFDLLVMPSRYE--------AMSY 297
Cdd:PRK00654  355 AGADMFLMPSRFEpcgltqlyALRY 379
PRK14099 PRK14099
glycogen synthase GlgA;
99-347 7.83e-09

glycogen synthase GlgA;


Pssm-ID: 237610 [Multi-domain]  Cd Length: 485  Bit Score: 57.42  E-value: 7.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312  99 DVIHGHSSKAG-ALTRLRLPGRHVPR-VYTPH--AF-----RTMDPTLGR-------GGRLIYGAIETLLARF-FTDHLV 161
Cdd:PRK14099  135 DIVHAHDWQAGlAPAYLHYSGRPAPGtVFTIHnlAFqgqfpRELLGALGLppsafslDGVEYYGGIGYLKAGLqLADRIT 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 162 AVSGdefAHALSIGISGKGM-------------SVIVNGVDT----PSPDMA-----------------QTVRASFGIPA 207
Cdd:PRK14099  215 TVSP---TYALEIQGPEAGMgldgllrqradrlSGILNGIDTavwnPATDELiaatydvetlaaraankAALQARFGLDP 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 208 D--AFVFGFIGRLSAQKAPERLLNAFGKAASAvrNSHVVMVGSGELEEEVRAAIAASGLQNRI-----------HLTSAf 274
Cdd:PRK14099  292 DpdALLLGVISRLSWQKGLDLLLEALPTLLGE--GAQLALLGSGDAELEARFRAAAQAYPGQIgvvigydealaHLIQA- 368

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1549894312 275 tgpqavpAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGG-AGTAVDHGENGYIVPNSEDV--SPLARAMIAAA 347
Cdd:PRK14099  369 -------GADALLVPSRFEPCGLTQLCALRYGAVPVVARVGGlADTVVDANEMAIATGVATGVqfSPVTADALAAA 437
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
159-329 3.28e-07

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 52.02  E-value: 3.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 159 HLVAVSGDEfAHALSIGISGKGMSVIVNGVDTPSPDMAQTVRasfGIPAdafVFGFIGRLSA--QKAPERLLNAFGKAAS 236
Cdd:PRK09922  137 HLAISSGIK-EQMMARGISAQRISVIYNPVEIKTIIIPPPER---DKPA---VFLYVGRLKFegQKNVKELFDGLSQTTG 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 237 avrNSHVVMVGSGELEEEVRAAIAASGLQNRIHLTSAFTGP-----QAVPAFDLLVMPSRYEAMSYVMLEAAAAGRPIII 311
Cdd:PRK09922  210 ---EWQLHIIGDGSDFEKCKAYSRELGIEQRIIWHGWQSQPwevvqQKIKNVSALLLTSKFEGFPMTLLEAMSYGIPCIS 286

                         170
                  ....*....|....*....
gi 1549894312 312 SD-VGGAGTAVDHGENGYI 329
Cdd:PRK09922  287 SDcMSGPRDIIKPGLNGEL 305
PRK10307 PRK10307
colanic acid biosynthesis glycosyltransferase WcaI;
137-351 4.41e-07

colanic acid biosynthesis glycosyltransferase WcaI;


Pssm-ID: 236670 [Multi-domain]  Cd Length: 412  Bit Score: 51.52  E-value: 4.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 137 LGRGGRL--IYGAIE-TLLARFftDHLVAVSGDEFAHALSIGISGKGMSVIVNGVDT------PSPDmAQTVRASFGIPA 207
Cdd:PRK10307  151 LLKGGKVarLATAFErSLLRRF--DNVSTISRSMMNKAREKGVAAEKVIFFPNWSEVarfqpvADAD-VDALRAQLGLPD 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 208 DAFVFGFIGRLSAQKAPERLLNAfGKAASAVRNSHVVMVGSGELEEEVRAAIAASGLQN-------------------RI 268
Cdd:PRK10307  228 GKKIVLYSGNIGEKQGLELVIDA-ARRLRDRPDLIFVICGQGGGKARLEKMAQCRGLPNvhflplqpydrlpallkmaDC 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 269 HLTsaftgPQAVPAFDLlVMPSRYEAMsyvmleaAAAGRPIIISDVGGAGTAVDHGENGYIVPnSEDVSPLARAMIA-AA 347
Cdd:PRK10307  307 HLL-----PQKAGAADL-VLPSKLTNM-------LASGRNVVATAEPGTELGQLVEGIGVCVE-PESVEALVAAIAAlAR 372


                  ....
gi 1549894312 348 DPEM 351
Cdd:PRK10307  373 QALL 376
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 215-344 1.47e-06

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 49.76  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 215 IGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGSGELEEEVRAAIAASGLQNRIHLTSAFTGPQAVPAFD---LLVMPS- 290
Cdd:cd03799   180 VGRLTEKKGLEYAIEAVAKLAQKYPNIEYQIIGDGDLKEQLQQLIQELNIGDCVKLLGWKPQEEIIEILDeadIFIAPSv 259

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1549894312 291 -----RYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGENGYIVPnSEDVSPLARAMI 344
Cdd:cd03799   260 taadgDQDGPPNTLKEAMAMGLPVISTEHGGIPELVEDGVSGFLVP-ERDAEAIAEKLT 317
GlgA COG0297
Glycogen synthase [Carbohydrate transport and metabolism];
184-297 1.85e-06

Glycogen synthase [Carbohydrate transport and metabolism];


Pssm-ID: 440066 [Multi-domain]  Cd Length: 476  Bit Score: 49.71  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 184 IVNGVDT----PSPDMA-----------------QTVRASFGIP--ADAFVFGFIGRLSAQKAPERLLNAFGKAASavRN 240
Cdd:COG0297   247 ILNGIDYdvwnPATDPYlpanysaddlegkaankAALQEELGLPvdPDAPLIGMVSRLTEQKGLDLLLEALDELLE--ED 324

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1549894312 241 SHVVMVGSGE--LEEEVRAaiAASGLQNRIHLTSAFTGP-----QAvpAFDLLVMPSRYE--------AMSY 297
Cdd:COG0297   325 VQLVVLGSGDpeYEEAFRE--LAARYPGRVAVYIGYDEAlahriYA--GADFFLMPSRFEpcglnqmyALRY 392
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 180-350 6.09e-06

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 48.13  E-value: 6.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 180 GMSVIVNGVDTP--SPDMAQTVRASFG--IPADAFVFGFIGR-LSAQKAPERLLNAFGKAASAVRNSHVVMVGSGELEEE 254
Cdd:cd03818   180 RISVIHDGVDTDrlAPDPAARLRLLNGteLKAGDPVITYVARnLEPYRGFHVFMRALPRIQARRPDARVVVVGGDGVSYG 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 255 VRAAIAASGLQ----------NRIHltsaFTGP-------QAVPAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGA 317
Cdd:cd03818   260 SPPPDGGSWKQkmlaelgvdlERVH----FVGKvpydqyvRLLQLSDAHVYLTYPFVLSWSLLEAMACGCPVIGSDTAPV 335

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1549894312 318 GTAVDHGENGYIVPnSEDVSPLARAMIAA-ADPE 350
Cdd:cd03818   336 REVIRDGRNGLLVD-FFDPDALAAAVLELlEDPD 368
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 187-316 1.11e-05

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 47.40  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 187 GVDTPS--P---DMAQTVRASFGIPaDAFVFGFIGRLSAQKAperlLNAFGKAASAVRNSHVVMVGSGELEEEVRAAIAA 261
Cdd:PLN02871  237 GVDSESfhPrfrSEEMRARLSGGEP-EKPLIVYVGRLGAEKN----LDFLKRVMERLPGARLAFVGDGPYREELEKMFAG 311

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1549894312 262 SglqnRIHLTSAFTG---PQAVPAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGG 316
Cdd:PLN02871  312 T----PTVFTGMLQGdelSQAYASGDVFVMPSESETLGFVVLEAMASGVPVVAARAGG 365
PelF NF038011
GT4 family glycosyltransferase PelF; Proteins of this family are components of the ...
 183-315 1.93e-05

GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter.


Pssm-ID: 411604 [Multi-domain]  Cd Length: 489  Bit Score: 46.46  E-value: 1.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 183 VIVNGVDTPSPDMAQTVRASfGIPAdafVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGSGELE----EEVRAA 258
Cdd:NF038011  284 VIPNGIDLPRLAPLRAQRPA-GIPP---VVGLIGRVVPIKDIKTFIRAMRTVVRAMPEAEGWIVGPEEEDpayaAECRSL 359

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1549894312 259 IAASGLQNRIHltsaFTGPQAV----PAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVG 315
Cdd:NF038011  360 VASLGLQDKVK----FLGFQKIddllPQVGLMVLSSISEALPLVVLEAFAAGVPVVTTDVG 416
PRK15490 PRK15490
Vi polysaccharide biosynthesis glycosyltransferase TviE;
176-337 2.40e-05

Vi polysaccharide biosynthesis glycosyltransferase TviE;


Pssm-ID: 185387 [Multi-domain]  Cd Length: 578  Bit Score: 46.62  E-value: 2.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 176 ISGKGMSVIVNGV----DTPSPDMAQTVRASFGIP---ADAFVFGfIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGS 248
Cdd:PRK15490  359 LEAKHFQVVYNGVlppsTEPSSEVPHKIWQQFTQKtqdADTTIGG-VFRFVGDKNPFAWIDFAARYLQHHPATRFVLVGD 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 249 GELEEEVRAAIAASGLQNRIhltsAFTGPQA-----VPAFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDH 323
Cdd:PRK15490  438 GDLRAEAQKRAEQLGILERI----LFVGASRdvgywLQKMNVFILFSRYEGLPNVLIEAQMVGVPVISTPAGGSAECFIE 513

                         170
                  ....*....|....
gi 1549894312 324 GENGYIVPNSEDVS 337
Cdd:PRK15490  514 GVSGFILDDAQTVN 527
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 246-338 1.72e-04

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 43.60  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 246 VGSGELEEEVRAaIAASGLQN-RIHLTSAFTGPQAVP-----AFDLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGT 319
Cdd:cd04946   263 IGGGPLKERLEK-LAENKLENvKVNFTGEVSNKEVKQlykenDVDVFVNVSESEGIPVSIMEAISFGIPVIATNVGGTRE 341

                          90
                  ....*....|....*....
gi 1549894312 320 AVDHGENGYIVpnSEDVSP 338
Cdd:cd04946   342 IVENETNGLLL--DKDPTP 358
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 194-337 8.28e-04

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 41.15  E-value: 8.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1549894312 194 DMAQTVRASFGIPADAFVFGFIGRLSAQKAPERLLNAFGKAASAVRNSHVVMVGSG--------ELEEEVRAAiaaSGLQ 265
Cdd:cd03792   182 DIRYYLEKPFVIDPERPYILQVARFDPSKDPLGVIDAYKLFKRRAEEPQLVICGHGavddpegsVVYEEVMEY---AGDD 258

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1549894312 266 NRIHLTSAFTGPQAVPAF----DLLVMPSRYEAMSYVMLEAAAAGRPIIISDVGGAGTAVDHGENGYIVPNSEDVS 337
Cdd:cd03792   259 HDIHVLRLPPSDQEINALqraaTVVLQLSTREGFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSVEGAA 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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