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Conserved domains on  [gi|1550199307|gb|RVO74780|]
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alpha-glucoside ABC transporter permease [Sinorhizobium meliloti]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 10003067)

carbohydrate ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of carbohydrate substrates including trehalose, lactose, arabinose, and maltodextrin

Gene Ontology:  GO:0042626|GO:0140359|GO:0008643|GO:0055085
PubMed:  25750732|24638992|30626703
TCDB:  3.A.1.1.-

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
71-332 4.65e-66

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 209.99  E-value: 4.65e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307  71 VYPVVQSVWLSLH----GRGGQNFVGLSNYSWMINDGEFRQSIFNNFLWLLVVPALSTFFGLIIAALTDR-IWWGNIAKT 145
Cdd:COG1175    36 LYPLLYTLYLSFTdwnlLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVLGLLLALLLNRkLRGRGFFRT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 146 LIFMPMAISFVGAAVIWKFIYDyraagsEQIGLLNAIVVALGGEPQAWITLPFWNNFFLMVILIWIQTGFAMVILSAALR 225
Cdd:COG1175   116 LFFLPWVISPVVVALIWKWLFN------PDYGLLNALLGALGLEPINWLGDPSLALPAVIIVTVWKGTGFNMLIFLAGLQ 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 226 GIPEETIEAAVIDGANGWQIFFKIMVPQIWGTIAVVWTTITILVLKVFDIVLAMTNGQW--QSQVLANLMFDWMfRGGGD 303
Cdd:COG1175   190 SIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGPgnSTTTLVLYIYQTA-FQQFD 268

                         250       260
                  ....*....|....*....|....*....
gi 1550199307 304 FGRGAAIAVVIMILVIPIMIWNIRNATRE 332
Cdd:COG1175   269 FGYASAIAVVLFLIILVLTLLQLRLLRRR 297
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
71-332 4.65e-66

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 209.99  E-value: 4.65e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307  71 VYPVVQSVWLSLH----GRGGQNFVGLSNYSWMINDGEFRQSIFNNFLWLLVVPALSTFFGLIIAALTDR-IWWGNIAKT 145
Cdd:COG1175    36 LYPLLYTLYLSFTdwnlLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVLGLLLALLLNRkLRGRGFFRT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 146 LIFMPMAISFVGAAVIWKFIYDyraagsEQIGLLNAIVVALGGEPQAWITLPFWNNFFLMVILIWIQTGFAMVILSAALR 225
Cdd:COG1175   116 LFFLPWVISPVVVALIWKWLFN------PDYGLLNALLGALGLEPINWLGDPSLALPAVIIVTVWKGTGFNMLIFLAGLQ 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 226 GIPEETIEAAVIDGANGWQIFFKIMVPQIWGTIAVVWTTITILVLKVFDIVLAMTNGQW--QSQVLANLMFDWMfRGGGD 303
Cdd:COG1175   190 SIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGPgnSTTTLVLYIYQTA-FQQFD 268

                         250       260
                  ....*....|....*....|....*....
gi 1550199307 304 FGRGAAIAVVIMILVIPIMIWNIRNATRE 332
Cdd:COG1175   269 FGYASAIAVVLFLIILVLTLLQLRLLRRR 297
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
71-254 6.89e-11

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 62.15  E-value: 6.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307  71 VYPVVQSVWLSLHGRG----GQNFVGLSNYSWMINDGEFRQSIFNNFLWLLVVPALSTFFGLIIAALTDRIWWGN-IAKT 145
Cdd:PRK10561   15 IWPAGEALWYSLQSVDpfgfSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAALVDYVVRGSrFYQT 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 146 LIFMPMAISFVGAAVIWKFIYDyraagsEQIGLLNAIVVALGGEpqawitlpfWNN--------FFLMVILIWIQTGFAM 217
Cdd:PRK10561   95 LMLLPYAVAPAVAAVLWIFLFN------PGRGLITHFLAEFGYD---------WNHaqnsgqamFLVVFASVWKQISYNF 159

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1550199307 218 VILSAALRGIPEETIEAAVIDGANGWQIFFKIMVPQI 254
Cdd:PRK10561  160 LFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLI 196
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 109-319 5.46e-07

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 49.20  E-value: 5.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 109 IFNNFLWLLVVPALSTFFGLIIAALTDRIWWG--NIAKTLIFMPMAISFVGAAVIWKFIYDYRAAGSEQIGLLNAIVVal 186
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKldRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALI-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 187 ggepqawitlpfwnnfflmvILIWIQTGFAMVILSAALRGIPEETIEAAVIDGANGWQIFFKIMVPQIWGTIAVVWTTIT 266
Cdd:cd06261    79 --------------------LALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAF 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1550199307 267 ILVLKVFDIVLAMTNGqwQSQVLANLMFDWMFRGGGDFGRGAAIAVVIMILVI 319
Cdd:cd06261   139 ARALGEFALVSFLGGG--EAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 179-322 2.14e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 44.60  E-value: 2.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 179 LNAIVVALGGEPQAWITLPFWNNFFLMVILIWIQTGFAMVILSAALRGIPEETIEAAVIDGANGWQIFFKIMVPQIWGTI 258
Cdd:pfam00528  30 LPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPI 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1550199307 259 AVVWTTITILVLKVFDIVLAMTNGQWQSQVLANLMFDWMFRGGGDFGRGAAIAVVIMILVIPIM 322
Cdd:pfam00528 110 LTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDIL 173
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
71-332 4.65e-66

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 209.99  E-value: 4.65e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307  71 VYPVVQSVWLSLH----GRGGQNFVGLSNYSWMINDGEFRQSIFNNFLWLLVVPALSTFFGLIIAALTDR-IWWGNIAKT 145
Cdd:COG1175    36 LYPLLYTLYLSFTdwnlLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVLGLLLALLLNRkLRGRGFFRT 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 146 LIFMPMAISFVGAAVIWKFIYDyraagsEQIGLLNAIVVALGGEPQAWITLPFWNNFFLMVILIWIQTGFAMVILSAALR 225
Cdd:COG1175   116 LFFLPWVISPVVVALIWKWLFN------PDYGLLNALLGALGLEPINWLGDPSLALPAVIIVTVWKGTGFNMLIFLAGLQ 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 226 GIPEETIEAAVIDGANGWQIFFKIMVPQIWGTIAVVWTTITILVLKVFDIVLAMTNGQW--QSQVLANLMFDWMfRGGGD 303
Cdd:COG1175   190 SIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGPgnSTTTLVLYIYQTA-FQQFD 268

                         250       260
                  ....*....|....*....|....*....
gi 1550199307 304 FGRGAAIAVVIMILVIPIMIWNIRNATRE 332
Cdd:COG1175   269 FGYASAIAVVLFLIILVLTLLQLRLLRRR 297
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 87-282 3.63e-17

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 80.52  E-value: 3.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307  87 GQNFVGLSNYSWMINDGEFRQSIFN----NFLWLLVvpalSTFFGLIIAALTDRIWWGNIAK---TLIFMPMAISFVGAA 159
Cdd:COG4209    66 GSPWVGLKNFKFLFSSPDFWRVLRNtlliSLLKLVF----GFPLPIILALLLNELRSKRFKKtvqTISYLPHFLSWVVVA 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 160 VIWKFIYdyraagSEQIGLLNAIVVALGGEPQAWITLPFWNNFFLMVILIWIQTGFAMVILSAALRGIPEETIEAAVIDG 239
Cdd:COG4209   142 GIVYQFL------SPDTGLVNQLLRALGGEPINFLTEPKYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDG 215

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1550199307 240 ANGWQIFFKIMVPQIWGTIavvwttITILVLKV-------FDIVLAMTNG 282
Cdd:COG4209   216 AGRWQQIWHITLPGIRPTI------VILLILNIgnilnvgFEQIYLLYNP 259
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 71-335 5.70e-13

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 68.25  E-value: 5.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307  71 VYPVVQSVWLSLHGRGGQNFV----GLSNYSWMINDGEFRQSIFNNFLWLLVVPALSTFFGLIIAALTDRI--WWGNIAK 144
Cdd:COG1176    27 VLPLLLLLVYSFTTRDPYGGVvpgfTLENYARLFTDPLYLKVLLRTLWIALLTTLICLLLGYPIAYFLARAppRWRNLLL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 145 TLIFMPMAISFVGAAVIWKFIYDYRaagseqiGLLNAIVVALGGEPQAwitLPFWNNFFLMVI-LIWIQTGFAMVILSAA 223
Cdd:COG1176   107 LLVILPFWTSFLVRTYAWIVLLGRN-------GLLNSLLLALGLIDEP---LRLLYTEFAVVIgLVYVYLPFMVLPLYAA 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 224 LRGIPEETIEAAVIDGANGWQIFFKIMVPQIWGTIAVVWTTITILVLKVFDIVLAMtnGQWQSQVLANLMFDWMFRGGGD 303
Cdd:COG1176   177 LEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALL--GGGKVLMIGNLIYQQFLSALNW 254

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1550199307 304 FGRGAAIAVVIMILVIPIMIWNIRNATRESGG 335
Cdd:COG1176   255 PLAAALAVVLLLIVLLVLLLYLRLLRRRRLLG 286
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
71-279 1.96e-11

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 64.80  E-value: 1.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307  71 VYPVVQSVWLSLhgrggqnFVGLSNYSWMINDGEFRQSIFNNFLWLLVVPALSTFFGLIIAALTDR--IWWGNIAKTLIF 148
Cdd:COG1178    25 LLPLLALLLRAF-------TDGLANFWALLSDPYLWRALGNTLLLALLVTLLSLLLGVPLAWLLARtdFPGRRLLRWLLL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 149 MPMAI-SFVGAaVIWKFIYDYRaagseqiGLLNAIVVALGGepqawITLPFWNNFFLMVILIWIQT-GFAMVILSAALRG 226
Cdd:COG1178    98 LPLALpPYVVA-LAWIALFGPN-------GLLNTLLRALFG-----LEPPDIYGLGGIILVLVLFNyPYVYLLLRAALRS 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1550199307 227 IPEETIEAAVIDGANGWQIFFKIMVPQIWGTIAVVWTTITILVLKVFDIVLAM 279
Cdd:COG1178   165 IDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVL 217
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
71-254 6.89e-11

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 62.15  E-value: 6.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307  71 VYPVVQSVWLSLHGRG----GQNFVGLSNYSWMINDGEFRQSIFNNFLWLLVVPALSTFFGLIIAALTDRIWWGN-IAKT 145
Cdd:PRK10561   15 IWPAGEALWYSLQSVDpfgfSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAALVDYVVRGSrFYQT 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 146 LIFMPMAISFVGAAVIWKFIYDyraagsEQIGLLNAIVVALGGEpqawitlpfWNN--------FFLMVILIWIQTGFAM 217
Cdd:PRK10561   95 LMLLPYAVAPAVAAVLWIFLFN------PGRGLITHFLAEFGYD---------WNHaqnsgqamFLVVFASVWKQISYNF 159

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1550199307 218 VILSAALRGIPEETIEAAVIDGANGWQIFFKIMVPQI 254
Cdd:PRK10561  160 LFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLI 196
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
6-277 2.21e-08

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 55.17  E-value: 2.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307   6 AAILTMVAGVLVCAAyfwstnLVLDWIFPSKGKFGAV---ASRNLRIANSIRPWLFLAPALLALTLYLVYPVVQSVWLSL 82
Cdd:COG1178   241 AAALALVLLLLVLLL------LLLERRLRRRRRYATVggrARRPRRVKLGRWRWLALALCLLLVLLGLLLPLLALLLWSL 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307  83 HGRGGQNFvGLSNYSWMINDGEFRQSIFNNFLWLLVVPALSTFFGLIIAALTDR--IWWGNIAKTLIFMPMAISfvgaav 160
Cdd:COG1178   315 TKALDDNL-TLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAYLVRRrrGRLARLLDRLAMLPYAVP------ 387

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 161 iwkfiydyraagseqigllnAIVVALGgepqawiTLPFWNNFFL------MVILIWIQT----GFAMVILSAALRGIPEE 230
Cdd:COG1178   388 --------------------GIVLGLG-------LLLLFNRPLPlllygtLAILVLAYVvrflPFALRSLEAALAQIDPS 440

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1550199307 231 TIEAAVIDGANGWQIFFKIMVPQIWGTIAVVWTTITILVLKVFDIVL 277
Cdd:COG1178   441 LEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATL 487
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 41-277 4.84e-08

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 53.47  E-value: 4.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307  41 AVASRNLRIANSIRPWLFLAPALLALTLYLVYPVVQSVWLSLHGRGGqnfVGLSNYSWMINDGEFRQSIFNNfLWLLVVP 120
Cdd:PRK15050   10 AAHAAAARRRRRLRPLLWLLLPLLVLAPLVVYPLVRVVLQSLTGEHG---LGLATYRAVLGSPDFRGALLTT-LQIAFAS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 121 A-----LSTFFGLIIAaltdriwwgniaktliFMPmaisFVGAAVIWKFIYDYRAAGSEQI-----------GLLNAIVV 184
Cdd:PRK15050   86 TagclvLGVLLALVLA----------------FVP----FPGASLVGRFIDTFVAFPSFLItlaftflygsaGSVNIALQ 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 185 ALGGEPqawitLPFWNNFFLM--VIL--IWIQTGFAMVILSAALRGIPEETIEAAVIDGANGWQIFFKIMVPQIWGTIAV 260
Cdd:PRK15050  146 RLFGLE-----APPLDFLYSPggVILaeITFYTPFVVRPLLAAFAQLDARQLEAAASLGASPWRVARRVILPEAWPALAA 220

                         250
                  ....*....|....*..
gi 1550199307 261 VWTTITILVLKVFDIVL 277
Cdd:PRK15050  221 GGSLCLLLTLNEFGIVL 237
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 93-261 5.59e-08

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 53.18  E-value: 5.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307  93 LSNYSWMINDGEFRQSIFNNflwlLVVPALSTFFGLIIAALT------DRIWWGNIAKTLIFMPMAISFVGAAVIWKFIY 166
Cdd:COG0395    60 LENYRAAFTDGPFGRYLLNS----LIVAVVSTVLSLLLSSLAayalarFRFRGRKLLFLLILATLMIPGQVLLIPLYLLF 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 167 DyraagseQIGLLNAIVValggepqawitlpfwnnffLMVILIWIQTGFAMVILSAALRGIPEETIEAAVIDGANGWQIF 246
Cdd:COG0395   136 R-------QLGLLNTYWG-------------------LILPYLAFGLPFGIFLLRQFFRSIPRELEEAARIDGASEFRIF 189

                         170
                  ....*....|....*
gi 1550199307 247 FKIMVPQIWGTIAVV 261
Cdd:COG0395   190 WRIVLPLSKPALATV 204
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 109-319 5.46e-07

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 49.20  E-value: 5.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 109 IFNNFLWLLVVPALSTFFGLIIAALTDRIWWG--NIAKTLIFMPMAISFVGAAVIWKFIYDYRAAGSEQIGLLNAIVVal 186
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKldRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALI-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 187 ggepqawitlpfwnnfflmvILIWIQTGFAMVILSAALRGIPEETIEAAVIDGANGWQIFFKIMVPQIWGTIAVVWTTIT 266
Cdd:cd06261    79 --------------------LALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAF 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1550199307 267 ILVLKVFDIVLAMTNGqwQSQVLANLMFDWMFRGGGDFGRGAAIAVVIMILVI 319
Cdd:cd06261   139 ARALGEFALVSFLGGG--EAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 73-262 7.30e-07

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 49.72  E-value: 7.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307  73 PVVQSVWLSLHGRGGQNFV----GLSNYSWMINDGEFRQSIFNNFLWLLVVPALSTFFGLIIA-ALT-DRIWWGNIAKTL 146
Cdd:COG1177    23 PILVLVLYSFNDSWFLTFPpegfTLRWYAELFSDPRLLDALLNSLLIALLSTLLATVLGTPAAlALArYRFRGRRLLLAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 147 IFMPMAISFVGAAviwkfiydyraagseqIGLLnaivvalggepQAWITLPFWNNFFLMVI-LIWIQTGFAMVILSAALR 225
Cdd:COG1177   103 LLLPLVVPGIVLG----------------VALL-----------LLFSALGLSGGLWGLILaHVVFTLPFVVLVVLARLQ 155

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1550199307 226 GIPEETIEAAVIDGANGWQIFFKIMVPQIWGTIAVVW 262
Cdd:COG1177   156 GFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGA 192
malF PRK10999
maltose ABC transporter permease MalF;
90-254 9.30e-07

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 50.34  E-value: 9.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307  90 FVGLSNYSWMINDGEFRQSIFNNFLWLLVVPALSTFF----GLIIAALtdrIWWGN-----IAKTLIFMPMAI-SFVgAA 159
Cdd:PRK10999  264 TIGWKNFTRVFTDEGIQKPFIAIFIWTVVFSLLTVVLtvavGMVLACL---VQWEAlkgkaVYRVLLILPYAVpSFI-SI 339

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 160 VIWKFIYDyraagsEQIGLLNAIVVALGGEPQAWITLPFWNNFFLMVILIWIQTGFAMVILSAALRGIPEETIEAAVIDG 239
Cdd:PRK10999  340 LIFKGLFN------QSFGEINMMLSALFGIKPAWFSDPTLAKTMILIVNTWLGYPYMMILCMGLLKAIPDDLYEASAMDG 413

                         170
                  ....*....|....*
gi 1550199307 240 ANGWQIFFKIMVPQI 254
Cdd:PRK10999  414 AGPFQNFFKITLPLL 428
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 179-322 2.14e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 44.60  E-value: 2.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550199307 179 LNAIVVALGGEPQAWITLPFWNNFFLMVILIWIQTGFAMVILSAALRGIPEETIEAAVIDGANGWQIFFKIMVPQIWGTI 258
Cdd:pfam00528  30 LPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPI 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1550199307 259 AVVWTTITILVLKVFDIVLAMTNGQWQSQVLANLMFDWMFRGGGDFGRGAAIAVVIMILVIPIM 322
Cdd:pfam00528 110 LTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDIL 173
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 208-259 3.26e-03

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 38.58  E-value: 3.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1550199307 208 LIWIQTGFAMVILSAALRGIPEETIEAAVIDGANGWQIFFKIMVPQIWGTIA 259
Cdd:COG0555   143 QTFVSLPFVVRTVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALL 194
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 227-252 6.92e-03

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 37.82  E-value: 6.92e-03
                          10        20
                  ....*....|....*....|....*.
gi 1550199307 227 IPEETIEAAVIDGANGWQIFFKIMVP 252
Cdd:COG3833   169 IPKELDEAAKIDGASHFQIFFRIILP 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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