|
Name |
Accession |
Description |
Interval |
E-value |
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-356 |
5.37e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 78.48 E-value: 5.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 13 LFAARALRDFGDGFVAILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMSI 92
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 93 VNDYALLLVVAFAGTInpsagSVSVFVPLEHAVLTREVASAERTRMFARYSLAGALASAVGALAAALpdfmttfgFGQLT 172
Cdd:COG2814 95 APSLWLLLAARFLQGL-----GAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL--------LADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 173 AIKLMFVVYAFLGLAGAVLYARMPPRITRGEPAKAALGPSRAI---VFKLAALFSLDAFAGGFVVQSLLALWLFEQFNLS 249
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLrrpRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 250 LAEAGVFFFWSGVLSAFSFPVAAWLSKRVGLINTMVFTHIPSSIALMLAAFAPTLPLALALLLIRAALSQMDVPTRSSYV 329
Cdd:COG2814 242 ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALV 321
|
330 340
....*....|....*....|....*..
gi 1550316626 330 MAVVTEAERAAAASFTSVPRSLAAAVS 356
Cdd:COG2814 322 AELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-379 |
6.70e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 78.39 E-value: 6.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 13 LFAARALRDFGDGFVAILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMSI 92
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 93 VNDYALLLVVAFAGTInpsagSVSVFVPLEHAVLTREVASAERTRMFARYSLAGALASAvgalaaalpdFMTTFG--FGQ 170
Cdd:cd17325 81 ATSYWQLLLARFLQGL-----ASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFL----------IGPLLGglLAD 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 171 LTAIKLMFVVYAFLGLAGAVLYARMPPRITRGEPAKAALGPSRAIVFKLA------ALFSLDAFAGGFV---VQSLLALW 241
Cdd:cd17325 146 ALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLlrdrrlLALFLAIFVLAFAfgaLEPFLPLY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 242 LFEQFNLSLAEAGVFFFWSGVLSAFSFPVAAWLSKRVGLINTMVFTHIPSSIALMLAAFAPTLPLALALLLIRAALSQMD 321
Cdd:cd17325 226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1550316626 322 VPTRSSYVMAVVTEAERAAAASFTSVPRSLAAAVSPALAGALFAASFRAWPFLICAAL 379
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL 363
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
27-379 |
2.57e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.34 E-value: 2.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 27 VAILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMSIVNDYALLLVVAFAG 106
Cdd:COG2271 29 LSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 107 TInpsagSVSVFVPLEHAVLTREVASAERTRMFARYSLAGALASAVGALAAALpdFMTTFGFgqltaiKLMFVVYAFLGL 186
Cdd:COG2271 109 GL-----GEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW--LLAAFGW------RAAFLILGLPGL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 187 AGAVLyarmppritrgepakaalgpsraiVFKLAALFSLDAFAGGFVVQSLLALWLFEQFNLSLAEAGVFFFWSGVLSAF 266
Cdd:COG2271 176 LLALL------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 267 SFPVAAWLSKRVG--LINTMVFTHIPSSIALMLAAFAPTLPLALALLLIRAALSQMDVPTRSSYVMAVVTEAERAAAASF 344
Cdd:COG2271 232 GSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL 311
|
330 340 350
....*....|....*....|....*....|....*
gi 1550316626 345 TSVPRSLAAAVSPALAGALFAASFRAWPFLICAAL 379
Cdd:COG2271 312 VNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
22-379 |
1.18e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.42 E-value: 1.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 22 FGDGFVAILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMSIVNDYALLLV 101
Cdd:cd17474 13 LGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 102 V-AFAGTINPSAGSVSVfvplehAVLTREVASAERTRMFARYSLAGALASAVGALAAalpdfmttfGFGQLTAIKLMFVV 180
Cdd:cd17474 93 GrALQGIGAAGLGPLAL------TLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLG---------GLLAAISWRYPFFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 181 YAFLGLAGAVLYARMPPRITRGEPAKAALGPSRAIVFKLAALFSLDAFAGG------FVVQSLLALWLFEQFNLSLAEAG 254
Cdd:cd17474 158 LAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFlyfflyFAFLTYLPFLLELLYGISPIIIG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 255 -VFFFWSGVLSAFSFPVAAWLSKRVGLINTMVFTHIPSSIALMLAAFAPTLPLALALLLIRAALSQMDVPTRSSYVMAVV 333
Cdd:cd17474 238 lLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1550316626 334 TEAERAAAASFTSVPRSLAAAVSPALAGALFAASFRAWPFLICAAL 379
Cdd:cd17474 318 PEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAI 363
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
13-379 |
1.24e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 56.28 E-value: 1.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 13 LFAARALRDFGDGFVAILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMSI 92
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 93 VNDYALLLVVAFAGtinpsAGSVSVFVPLEHAVLTREVASAERTRMFARYSLAGALASAVGALAAALPDFMTTFGFgqlt 172
Cdd:cd06174 81 APSFWLLLLGRFLL-----GLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGW---- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 173 aiKLMFVVYAFLGLAGAVLYARMPPRITRGEPAKAALGPSRAIV-----------FKLAALFSLDAFAGGFVVQSLLALW 241
Cdd:cd06174 152 --RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLkllkrvlknpgLWLLLLAIFLVNLAYYSFSTLLPLF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 242 LFEQFNLSLAEAGVFFFWSGVLSAFSFPVAAWLSKRV-GLINTMVFTHIPSSIALMLAAFAPTLPLALALLLIRAALSQM 320
Cdd:cd06174 230 LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGG 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 321 DVPTRSSYVMAVVTEAERAAAASFTSVPRSLAAAVSPALAGALFAASFR-AWPFLICAAL 379
Cdd:cd06174 310 LLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGlTGAFLVLAVL 369
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
27-379 |
1.45e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.02 E-value: 1.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 27 VAILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMSIVNDYALLLVVAFAg 106
Cdd:cd17324 18 IQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARAL- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 107 tinpSAGSVSVFVPLEHAVLTREVASAERTRMFARYSLAGALASAVGALAAALpdfmttfgFGQLTAIKLMFVVYAFLGL 186
Cdd:cd17324 97 ----AGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGL--------LGQLLGWRAAFLAIAVLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 187 AGAVLYARMPPRITRGEPAKAALGPSRAIVFK-----LAALFSLDAFAGGFVVQSLLALWLFEQFNLSLAEAGVFFFWSG 261
Cdd:cd17324 165 LAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRnprlrLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 262 VLSAFSFPVAAWLSKRVGLINTMVFTHIPSSIALMLAAFAPTLPLALALLLIRAALSQMDVPTRSSYVMAVVTEAeRAAA 341
Cdd:cd17324 245 VAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLA 323
|
330 340 350
....*....|....*....|....*....|....*...
gi 1550316626 342 ASFTSVPRSLAAAVSPALAGALFAASFRAWPFLICAAL 379
Cdd:cd17324 324 SSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAAL 361
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
230-399 |
1.95e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 55.70 E-value: 1.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 230 GGFVVQSLLALWLFEQFNLSLAEAGVFFFWSGVLSAFSFPVAAWLSKRVGLINTMVFTHIPSSIALMLAAFAPTLPLALA 309
Cdd:cd17329 14 GFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 310 LLLIRAALSQMDVPTRSSYVMAVVTEAERAAAASFTSVPRSLAAAVSPALAGALFAASFRaWPFLICAALKITYDVLLLL 389
Cdd:cd17329 94 ALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFR-LLFLAAAVLFLLAALVLLF 172
|
170
....*....|
gi 1550316626 390 QFRHHKPPEE 399
Cdd:cd17329 173 LLPETRPKRR 182
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
21-300 |
2.10e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 55.64 E-value: 2.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 21 DFGDGFVAILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRgLLLAAAGLMVASGVAMS--IVNDYAL 98
Cdd:cd17478 9 DFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRR-YLLPLGPLLTGLGLSLLgfAPNYWLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 99 LLVVAFAGTinpsagSVSVFVPlEHAVLTREVASAERTRMFARYSLAGALASAVGALAAALpdFMTTFGFgqltaiKLMF 178
Cdd:cd17478 88 LLLVALAGI------GSAAFHP-EGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAA--LVALFGG------LGLL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 179 VVYAFLGLAGAVLYARMPP---RITRGEPAKAALGPSRAIVFKLAALFSLDAFAGGFVVQSL---LALWLFEQFNlSLAE 252
Cdd:cd17478 153 ILLIIPGLAVALLLLRLRPlkkPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLttfLPFYLVQRGY-SLVF 231
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1550316626 253 AGVFFFWSGVLSAFSFPVAAWLSKRVGLINTMVFTHIPSSIALMLAAF 300
Cdd:cd17478 232 AGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLL 279
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
28-399 |
3.51e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 54.89 E-value: 3.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 28 AILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMSIVNDYALLLVVAFAGT 107
Cdd:COG2223 25 SVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 108 INpSAGSVSVFVPLehavLTREVASAERTRMFARYSLAGALASAVGALAAalPDFMTTFGfgqltaIKLMFVVYAFLGLA 187
Cdd:COG2223 105 IG-GGGSFAVGIAL----VSKWFPPDRRGLALGLAAGGGNLGAAVAAFLA--PLLIAAFG------WRNAFLILGILLLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 188 GAVLYARM--PPRITRGEPAKAALGPSRAIV----FKLAALFSLDAFAGGFVVQSLLALWLFEQFNLSLAEAGVFFFWSG 261
Cdd:COG2223 172 VAVLAWLFlrDPPAGAAAAAKASLRDQLEALrdprFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 262 VLSAFSFPVAAWLSKRVGLINTMVFTHIPSSIALMLAAFAPT-LPLALALLLIRAALSQMDVPTRSSYVMAVVTEAERAA 340
Cdd:COG2223 252 LLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGA 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 341 AASFTSVPRSLAAAVSPALAGALFAAS-FRAWPFLICAALKITYDVLLLLQFRHHKPPEE 399
Cdd:COG2223 332 VYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-357 |
1.15e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.19 E-value: 1.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 13 LFAARALRDFGDGFVAILLPVYLL-ALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMS 91
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 92 IVNDYALLLVVAFAGTInpsagSVSVFVPLEHAVLTREVASAERTRMFARYSLAGALASAVGALAAALpdfmttfgFGQL 171
Cdd:pfam07690 81 FASSLWLLLVLRVLQGL-----GAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL--------LASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 172 TAIKLMFVVYAFLGLAGAVLYARMPPRITRGEPAKAALGPSRA-----IVFKLAALFSLDAFAGGFVVQSLLALWLF--- 243
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLivawkALLRDPVLWLLLALLLFGFAFFGLLTYLPlyq 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 244 EQFNLSLAEAGVFFFWSGVLSAFSFPVAAWLSKRVGLINTMVFTH---IPSSIALMLAAFAPTLPLALALLLIRAALSQM 320
Cdd:pfam07690 228 EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALlllILAALGLLLLSLTLSSLWLLLALLLLGFGFGL 307
|
330 340 350
....*....|....*....|....*....|....*..
gi 1550316626 321 DVPTRSSYVMAVVTEAERAAAASFTSVPRSLAAAVSP 357
Cdd:pfam07690 308 VFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-390 |
2.19e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.15 E-value: 2.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 12 YLFAARALRDFGDGFVAILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMS 91
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 92 IVNDYALLLVVAFAGTINPSAGSVSVFVPLEHAVLTREVASAERTRMFARYSLAGALASAVGALAAALpdFMTTFGFGQL 171
Cdd:cd06173 83 LLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGL--LVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 172 TAIklmfVVYAFLGLAGAVLYARMPPRITRGEPAKAALGPSRAIVFKL-------AALFSLDAFAG-GFVVQSLLALWLF 243
Cdd:cd06173 161 FAI----NALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLrrspllrLLLLALALFALlGGALTVLLPLLAK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 244 EQFNLSLAEAGVFFFWSGVLSAFSFPVAAWLSKRVGLINTMVFTHIPSSIALMLAAFAPTLPLALALLLIRAALSQMDVP 323
Cdd:cd06173 237 EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNV 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1550316626 324 TRSSYVMAVVTEAERAAAASFTSVPRSLAAAVSPALAGALFAASFRAWPFLICAALKITYDVLLLLQ 390
Cdd:cd06173 317 PLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
13-379 |
4.09e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.38 E-value: 4.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 13 LFAARALRDFGDGFVAILLPVYLL-ALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMS 91
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHqQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 92 IVNDYALLLVVAFAGTInpsagSVSVFVPLEHAVLTREVASAERTRMFARYSLAGALASAVGALAAAlpdFMTTFGFGQL 171
Cdd:cd17329 84 FAHSPWLFAIALVLTGF-----GGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGG---LLLLYSFRLL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 172 TAIK-LMFVVYAFLglagaVLYARMPPRITRGEPAKAALGPSRAIVFK-----LAALFSLDAFAGGFVVQSLLALWLFEQ 245
Cdd:cd17329 156 FLAAaVLFLLAALV-----LLFLLPETRPKRRAAEKTEILRGYKIVLRdraflLFLLASFLISLIYFQLESTLPVYVVEI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 246 FNLSLAEAGVFFFWSGVLS-AFSFPVAAWLSKRvGLINTMVFTHIPSSIALMLAAFAPTLPLALALLLIRAALSQMDVPT 324
Cdd:cd17329 231 LGLGESLLGLLLALNALLIvLLQFPVARLVERF-RLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPA 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1550316626 325 RSSYVMAVVTEAERAAAASFTSVPRSLAAAVSPALAGALFAASFRAWPFLICAAL 379
Cdd:cd17329 310 VQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAAL 364
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
31-379 |
1.59e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.43 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 31 LPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMSIVNDYALLLVVAFAGTInp 110
Cdd:cd17489 19 LPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGI-- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 111 sagSVSVFVPLEHAVLTREVASAERTRMFARYSLAGALASAVGALAAALpdfmttfgFGQLTAIKLMFVVYAFLGLAGAV 190
Cdd:cd17489 97 ---GWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLF--------LYQHLGFAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 191 LYARMPPRIT-RGEPAKAALGPSRAIVFKLAALFSLDAFAGGF---VVQSLLALWLFEQFnlsLAEAGVFFFWSGVLSAF 266
Cdd:cd17489 166 LVFLVKDPPPvAAEEAEAGTRAFRRLVEKKVLPPALILFLASIaygAISTFLPLYAAERG---ISNAGLFFTVYAIALLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 267 SFPVAAWLSKRVGLINTMVFTHIPSSIALMLAAFAPTLPLALALLLIRAALSQMDVPTRSSYVMAVVTEAERAAAASFTS 346
Cdd:cd17489 243 SRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFF 322
|
330 340 350
....*....|....*....|....*....|...
gi 1550316626 347 VPRSLAAAVSPALAGALFAASFRAWPFLICAAL 379
Cdd:cd17489 323 IFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVV 355
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
22-367 |
2.23e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.43 E-value: 2.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 22 FGDGFVAILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRG-----LLLAAAGLMVASGVAMSIVND- 95
Cdd:COG2211 25 AFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDl 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 96 -YALLLVVAFAGTINPSAGSVSVFVPLE--HAVLTREvaSAERTRMFARYSLAGALASAVGALAAALpdFMTTFGFGQLT 172
Cdd:COG2211 105 sPTGKLIYALVTYLLLGLAYTLVNIPYSalGAELTPD--YEERTRLSSWRFAFAGLGGLLASVLPPP--LVAAFGGDAAL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 173 AIKLMFVVYAFLGLAGAVLYARMPPRITRGEPAKAALGPSRAIVFK-----LAALFSLDAFAGGFVVQSLLALWLFEQFN 247
Cdd:COG2211 181 GYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKnrpflLLLLAYLLFFLALALVAALLLYYFKYVLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 248 LSLAEAGVFFFWSGVLSAFSFPVAAWLSKRVGLINTMVFTHIPSSIALMLAAFAPT--LPLALALLLIRAALSQMDVPTR 325
Cdd:COG2211 261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPgnLWLLLVLAALAGIGLGAILVLP 340
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1550316626 326 SSYVMAVVTEAE-------RAAAASFTSVPRSLAAAVSPALAGALFAAS 367
Cdd:COG2211 341 WAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
217-370 |
2.73e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.55 E-value: 2.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 217 FKLAALFSLDAFAGGFVVQSLLALWLFEQFNLSLAEAGVFFFWSGVLSAFSFPVAAWLSKRVGLINTMVFTHIPSSIALM 296
Cdd:cd17321 170 FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1550316626 297 LAAFAPTLPLALALLLIRAAL---SQMDVPTRSSYVMAVVTEAERAAAASFTSVPRSLAAAVSPALAGALFAASFRA 370
Cdd:cd17321 250 LLALLGADSSVWLLLPGLVLLglgLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSA 326
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
228-379 |
3.22e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.57 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 228 FAGGFVVQSLLALWLFEQFNLSLAEAGVFFFWSGVLSAFSF-PVAAWLSKRVGLINTMVFTHIPSSIALMLAAFAPTLPL 306
Cdd:cd17330 187 ALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPL 266
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1550316626 307 ALALLLIRAALSQMDVPTRSSYVMAVVTEAERAAAASFTSVPRSLAAAVSPALAGALFAASFRAWPFLICAAL 379
Cdd:cd17330 267 LVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGL 339
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
22-300 |
3.71e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.15 E-value: 3.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 22 FGDGFVAILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMSIVNDYALLLV 101
Cdd:COG0738 22 FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 102 VAFAGTInpSAGSVSVFVPLEHAVLTREVASAERTRMFARYSLAGALASAVGAlaaalpdFMTTFGFGQLTAIKLMFVVY 181
Cdd:COG0738 102 ALFLLGL--GLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGG-------LLILLGLSLSWHLPYLILAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 182 AFLGLAGAVLYARMPPRITRGEPAKAALGPSRAIV-FKLAALFSLDAFAGGFV---VQSLLALWLFEQFNLSLAEAGVFF 257
Cdd:COG0738 173 LLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLkNPRLLLGGLAIFLYVGAegaIGDWLPLYLKDVLGLSEATAALGL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1550316626 258 FWSGVLSAFSFPVAAWLSKRVGLINTMVFTHIPSSIALMLAAF 300
Cdd:COG0738 253 SLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALL 295
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
227-397 |
4.63e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 4.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 227 AFAGGFVVQSLLALWLFEQFNLSLAEAGVFFFWSGVLSAFSFPVAAWLSKRVGLINTMVFTHIPSSIALMLAAFAPTLPL 306
Cdd:pfam07690 8 AALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 307 ALALLLIRAALSQMDVPTRSSYVMAVVTEAERAAAASFTSVPRSLAAAVSPALAGALFAASFRAWPFLICAALKITYDVL 386
Cdd:pfam07690 88 LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL 167
|
170
....*....|.
gi 1550316626 387 LLLQFRHHKPP 397
Cdd:pfam07690 168 LLLPRPPPESK 178
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
207-398 |
4.82e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.88 E-value: 4.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 207 AALGPSRAIVFKLAALFSLDAFAGGFVVQSLLAlWLFEQFNLSLAEAGVFFFWSGVLSAFSFPVAAWLSKRVGLINTMVF 286
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 287 THIPSSIALMLAAFAPTLPLALALLLIRAALSQMDVPTRSSYVMAVVTEAERAAAASFTSVPRSLAAAVSPALAGALFAA 366
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190
....*....|....*....|....*....|..
gi 1550316626 367 SFRAWPFLICAALKITYDVLLLLQFRHHKPPE 398
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAA 192
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
30-105 |
7.58e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.39 E-value: 7.58e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1550316626 30 LLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMSIVNDYALLLVVAFA 105
Cdd:cd17477 210 LLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLF 285
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
28-280 |
4.37e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.82 E-value: 4.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 28 AILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMSIVNDYALLLVVAFAgt 107
Cdd:cd06180 19 TPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFL-- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 108 inpsAGSVSVFVPLEHAVLTREVASAERTRMFARYSLAGALASAVGALAAALpdFMTTFGFGQLTAIKLMFVVYAFLGLA 187
Cdd:cd06180 97 ----AGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVP--AGLGGGLSWRAGWLALALLSAVLLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 188 GAVLYARMPPRITRGEPAKAALGPSRAiVFKLAALFSLDAFaGGFVVQSLLALWLFEQFNLSLAeAGVFFFWSGVLSAFS 267
Cdd:cd06180 171 SFLLLRRGPSAPTEASAAESAPGLNRP-LWRLALAYGLFGF-GYIITATFLPLIARETGAGSLL-AGLLWSLFGLAAVPS 247
|
250
....*....|...
gi 1550316626 268 FPVAAWLSKRVGL 280
Cdd:cd06180 248 CFLWGALSDRWGT 260
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
13-383 |
4.70e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 4.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 13 LFAARALRDFGDGFVAILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVAMSI 92
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 93 VNDYALLLVVAFAGTInpsaGSVSVFVPLEHAVLTReVASAERTRMFARYSLAgalasavgalaaalpdFMTTFGFGQL- 171
Cdd:cd17477 81 TDSPWVWFLLRFVMGI----GLAGLFVVSESWLNAL-ATNENRGRVLGLYSTV----------------LGLGFALGPLl 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 172 -----TAIKLMFVVYAFLGLAGAVLYARMPPRITRGEPAKAAlgpSRAIVFKLAALFSLDAFAGGFVVQSLLALW--LFE 244
Cdd:cd17477 140 lalvgTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESI---SLRRLLRIAPLALLGAFVAGFLEGAFYSLLplYGL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 245 QFNLSLAEAGVFFFWSGVLSAFSFPVAAWLSKRVGLINTMVFTHIPSSIALMLAAFAPTLPLALALLLIRAALSQMDV-P 323
Cdd:cd17477 217 RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLyT 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 324 TRSSYVMAVVTEAERAAAASFTSVPRSLAAAVSPALAGALFAASFRAWPFLICAALKITY 383
Cdd:cd17477 297 LALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLF 356
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
28-279 |
7.49e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 38.39 E-value: 7.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 28 AILLPVYLLALGFSPLQVGVIATASLSGSALLTIAIGFLGARRDLRGLLLAAAGLMVASGVA-MSIVNDYALLLVVAF-- 104
Cdd:cd17341 19 APLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLAlALAVSSYWGLLVLGFll 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 105 ---AGTINPSAGSVSVFVPLEHAVLTREVAsaertrmfaryslAGALASAVGALAAALPDFMTTFGF-GQLTAIKLMFVV 180
Cdd:cd17341 99 gfaGANFASGQPWASFWFPKEKIGGAAGGI-------------AGAGNMGVAVSQLLAPLIAGAIVFdGGFVGWRNAFFV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550316626 181 YAFLGLAGAVLYARMP--------PRITRGEPAKAALGPSRAIVFKLAALFSLDAFAGgfvVQSLLALWLFEQFNLSLAE 252
Cdd:cd17341 166 PGILLAIAAVLVLLFGddlptgkaSALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVG---FSNVLPTYFKTRFGLPLVT 242
|
250 260
....*....|....*....|....*..
gi 1550316626 253 AGVFFFWSGVLSAFSFPVAAWLSKRVG 279
Cdd:cd17341 243 AGILAALFPLAGALARPAGGWLSDRFG 269
|
|
| |
