|
Name |
Accession |
Description |
Interval |
E-value |
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
6-485 |
1.87e-57 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 205.87 E-value: 1.87e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 6 VIFASAFAYLLLLFAVASYGDRRARRNE---IAAK--GRPLVYALSLAIYCTSWTYFGGVGLAAERGLEFTGIYIGP-IL 79
Cdd:cd10322 1 IDLIIVVVYLALLLGIGLYASKKVKSSEdffLAGRslGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAaLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 80 MFTLGMPLIRRIVRLAKTekltSVADFVAARYGkNPAVAAIVALISLVGAIPYIALQLKAVSSSVATMIDTSdygigsge 159
Cdd:cd10322 81 ALLLALFLAPRLRRLGKT----TIPETILERYY-SKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIP-------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 160 nfVDLPLLVTLFLACFAIVFGTRHtdatehqdGLILAIAMESVVKLVAMLTVGVYIVFVLFG-GPANLWAEAQQSATVIA 238
Cdd:cd10322 148 --YTVAVIIAAVIVILYTVFGGMR--------AVAWTDVIQGIVMLIGVLVAAIFILSKVGGgGFSALAAALPALLLALG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 239 ALEYQTPVArWILMIALSAFGIIMLPRQFHVTVVEnRTDNELRTAGILFPLYLIAINAFVLPIAIAGILTFSGSGNADLY 318
Cdd:cd10322 218 PGGGLGWST-ILSLILLTGLGVLALPQVFQRILAA-KDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLENPDLA 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 319 LLALPLAGDVPLVTLFTFIGGFSAATAMVIVASVALSIMVSNDIVMPVFLRRRLGTRgslqedmagtLLNIRRTAIFVVL 398
Cdd:cd10322 296 LPTLINSLLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINPKASDKK----------LLRVSRIAVVVVG 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 399 FLGYGYyrAADISAGLASLGLLSFAAIAQMAPALLGGLVWRQANARGAIAGMVSGFLVWAYVLFLPSLGGPdnsHIASTV 478
Cdd:cd10322 366 VLALLL--ALLPPSILLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLASPL---GIDPII 440
|
....*..
gi 1550380708 479 LSFLLPF 485
Cdd:cd10322 441 PALLVSL 447
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
693-1017 |
7.89e-53 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 188.58 E-value: 7.89e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 693 IVAILARRGDVRKDEEKALIANFLTLDKPFLLELAGGARILEVRSNAMPDKGIVTTYTDITQRVAADMALKQANETLELR 772
Cdd:COG0642 2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 773 VAERTGELTRVNRELGEARAAAEEANIGKTRFFAAAGHDILQPLNAARLYSSSLVERLgDSDNRALVQNIDSSLESVEAI 852
Cdd:COG0642 82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL-DEEQREYLETILRSADRLLRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 853 LGAVLDISRLDTGAMKPRLQSVPLDELLRRIETDFAPMARAKDIELVIM--PTSLAARSDPNLLRRLVQNLVSNAIKYTL 930
Cdd:COG0642 161 INDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDlpDDLPTVRGDPDRLRQVLLNLLSNAIKYTP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 931 QG-KVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLeEGARTASGLGLGLSIVDRISRVLNHPVGLQSKPGKGT 1009
Cdd:COG0642 241 EGgTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRT-DPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGT 319
|
....*...
gi 1550380708 1010 GFKVTVPL 1017
Cdd:COG0642 320 TFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
801-1020 |
2.57e-49 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 175.10 E-value: 2.57e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 801 KTRFFAAAGHDILQPLNAARLYSSSLVERLGDSDN--RALVQNIDSSLESVEAILGAVLDISRLDTGAMKPRLQSVPLDE 878
Cdd:COG2205 16 KSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEerRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLELEPVDLAE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 879 LLRRIETDFAPMARAKDIELVIM--PTSLAARSDPNLLRRLVQNLVSNAIKYTLQG-KVLVGVRRHGQTATIEVLDSGIG 955
Cdd:COG2205 96 LLEEAVEELRPLAEEKGIRLELDlpPELPLVYADPELLEQVLANLLDNAIKYSPPGgTITISARREGDGVRISVSDNGPG 175
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1550380708 956 IPSSKFRTVFKEFARLeEGARTASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPLDKS 1020
Cdd:COG2205 176 IPEEELERIFERFYRG-DNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
524-1020 |
2.46e-42 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 163.03 E-value: 2.46e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 524 LERFQAGVFITRRSRTERTFRGRKTKVTVRDLKTTIGRYMGEERMQRSFHTYEQQSGRWLDDNASADMALVHFSEQLLGS 603
Cdd:COG4251 20 LLLLLLLVLLLALALLLLLALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 604 AIGSSSARLVLSLVLQRMDDTSSDTAWLLDQASEALQYNQDMLHTALSQMDQGIAVFDNANNLIIWNRRFRELMDLPEAA 683
Cdd:COG4251 100 LLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 684 GQvGFPLADIVAILARRGDVRKDEEKALIANFLTLDKPFLLELAGGARILEVRSNAMPDKGIVTTYTDITQRVAADMALK 763
Cdd:COG4251 180 LL-LLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 764 QANETLELRVAERTGELTRVNRELgearaaaeeanigkTRFFAAAGHDILQPLNAARLYSSSLVERLG---DSDNRALVQ 840
Cdd:COG4251 259 LELEELEEELEERTAELERSNEEL--------------EQFAYVASHDLREPLRKISGFSQLLEEDYGdklDEEGREYLE 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 841 NIDSSLESVEAILGAVLDISRLDTGAMkpRLQSVPLDELLRRIETDFAPMARAKDIELVI--MPTslaARSDPNLLRRLV 918
Cdd:COG4251 325 RIRDAAERMQALIDDLLAYSRVGRQEL--EFEPVDLNELLEEVLEDLEPRIEERGAEIEVgpLPT---VRGDPTLLRQVF 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 919 QNLVSNAIKYT---LQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLeEGARTASGLGLGLSIVDRIsrVL 995
Cdd:COG4251 400 QNLISNAIKYSrpgEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRL-HSRDEYEGTGIGLAIVKKI--VE 476
|
490 500
....*....|....*....|....*..
gi 1550380708 996 NH--PVGLQSKPGKGTGFKVTVPLDKS 1020
Cdd:COG4251 477 RHggRIWVESEPGEGATFYFTLPKAPA 503
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
801-1020 |
2.59e-41 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 157.02 E-value: 2.59e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 801 KTRFFAAAGHDILQPLNAARLYSSSLVERLGDS--DNRALVQNIDSSLESVEAILGAVLDISRLDTGAMKPRLQSVPLDE 878
Cdd:COG5002 165 RREFVANVSHELRTPLTSIRGYLELLLDGAADDpeERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAE 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 879 LLRRIETDFAPMARAKDIELV--IMPTSLAARSDPNLLRRLVQNLVSNAIKYTLQG-KVLVGVRRHGQTATIEVLDSGIG 955
Cdd:COG5002 245 LLEEVVEELRPLAEEKGIELEldLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGgTITVSLREEDDQVRISVRDTGIG 324
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1550380708 956 IPSSKFRTVFKEFARLEEG-ARTASGLGLGLSIVDRIsrVLNH--PVGLQSKPGKGTGFKVTVPLDKS 1020
Cdd:COG5002 325 IPEEDLPRIFERFYRVDKSrSRETGGTGLGLAIVKHI--VEAHggRIWVESEPGKGTTFTITLPLARE 390
|
|
| PAS_7 |
pfam12860 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
650-759 |
2.25e-37 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 432837 [Multi-domain] Cd Length: 115 Bit Score: 136.13 E-value: 2.25e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 650 LSQMDQGIAVFDNANNLIIWNRRFRELMDLPEAAGQVGFPLADIVAILARRGDVRKDEEKALIANFLTL---DKP--FLL 724
Cdd:pfam12860 1 LENMSQGLSVFDADLRLVAWNRRYRELLDLPEDLVQVGVPFEEIIRYNAERGEYGPGDVEAHVRRRLAAaraGSPhyFER 80
|
90 100 110
....*....|....*....|....*....|....*
gi 1550380708 725 ELAGGaRILEVRSNAMPDKGIVTTYTDITQRVAAD 759
Cdd:pfam12860 81 ERPDG-RVIEIRGNPLPDGGFVTTFTDITERRRAE 114
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
5-525 |
7.17e-37 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 146.12 E-value: 7.17e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 5 SVIFASAFAYLLLLFAVASYGDRRARRNE--IAAKGR--PLVYALSL-AIYCTSWTYFGGVGLAAERGLEFTGIYIG-PI 78
Cdd:COG0591 3 TLDLIIIILYLLLLLGIGLYASRRTKSLEdyFLAGRSlgWWVLALSLgATWLSAWTFLGVPGLAYAYGLSALWYALGyAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 79 LMFTLGMPLIRRIVRLakteKLTSVADFVAARYGKnpAVAAIVALISLVGAIPYIALQLKAVSSSVATMIDTSdygigsg 158
Cdd:COG0591 83 GALLLALFFAPRLRRL----GALTIPEFLEKRFGR--GLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIP------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 159 enfVDLPLLVTLFLACFAIVFGtrhtdatehqdGLiLAIAMESVVKLVAMLTVGVYIVFVLF---GGPANLWAEAQQSA- 234
Cdd:COG0591 150 ---YWLGILIGALIVLLYTVLG-----------GL-RAVAWTDVLQGILMLVGLILLLIVALsalGGFGELFAALPAPGl 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 235 -TVIAALEYQTPVArWILMIALSAFGIIMLPrQFHVTVVENRTDNELRTAGILFPLYLIAINAFVLPIAIAGILTFSGSG 313
Cdd:COG0591 215 lSLFPGLGFTGWLA-FLGLFLAIGLGYFGQP-HIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDLP 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 314 NADlYLLALP-LAGDV--PLVTLFTFIGGFSAATAMVIVASVALSIMVSNDIVMPvFLRRRLGTRgslqedmagTLLNIR 390
Cdd:COG0591 293 LAD-PDLALPlLILELlpPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKP-FIKPKASDK---------QLLRVS 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 391 RTAIFVVLFLGYGYyrAADISAGLASLGLLSFAAIAQ-MAPALLGGLVWRQANARGAIAGMVSGFLVWAYVLFLPSLGGP 469
Cdd:COG0591 362 RLAVLVVGLLALLL--ALLFPSSILDLVLLAWGGLGAaLLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLGGPLGP 439
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 1550380708 470 dnshiastvlsfllpftdlfsgaqsDPLVNATALSMLVNVAAYIVGSLTRAPKPLE 525
Cdd:COG0591 440 -------------------------FGWLYPILPGLLVSLLVFVVVSLLTKPPSEE 470
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
632-1021 |
2.44e-30 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 125.46 E-value: 2.44e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 632 LDQASEALQYNQDMLHTALSQMDQGIAVFDNANNLIIWNRRFRELMDLPEAAgQVGFPLADIVAILARRgdvrkdeekAL 711
Cdd:COG5000 78 LKEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEE-LIGKPLEELLPELDLA---------EL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 712 IANFLTLDKPFLLELA-GGARILEVRSNAMPDKGIVTTYTDITqrvaadmalkqanetlELRVAERT---GELTRVnrel 787
Cdd:COG5000 148 LREALERGWQEEIELTrDGRRTLLVRASPLRDDGYVIVFDDIT----------------ELLRAERLaawGELARR---- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 788 gearaaaeeanIGktrffaaagHDILQPLNAARLYSSSLVERLGDS------DNRALVQNIDSSLESVEAILGAVLDISR 861
Cdd:COG5000 208 -----------IA---------HEIKNPLTPIQLSAERLRRKLADKleedreDLERALDTIIRQVDRLKRIVDEFLDFAR 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 862 LDtgamKPRLQSVPLDELLRRIETDFAPMARAKDIELV--IMPTSLAARSDPNLLRRLVQNLVSNAIKYTLQ-GKVLVGV 938
Cdd:COG5000 268 LP----EPQLEPVDLNELLREVLALYEPALKEKDIRLEldLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEgGEIEVST 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 939 RRHGQTATIEVLDSGIGIPSSKFRTVF------KEfarleegartaSGLGLGLSIVDRIsrVLNH--PVGLQSKPGKGTG 1010
Cdd:COG5000 344 RREDGRVRIEVSDNGPGIPEEVLERIFepffttKP-----------KGTGLGLAIVKKI--VEEHggTIELESRPGGGTT 410
|
410
....*....|.
gi 1550380708 1011 FKVTVPLDKSA 1021
Cdd:COG5000 411 FTIRLPLAEEA 421
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
910-1017 |
1.43e-27 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 108.12 E-value: 1.43e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 910 DPNLLRRLVQNLVSNAIKYTL-QGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEGARTASGLGLGLSIV 988
Cdd:smart00387 2 DPDRLRQVLSNLLDNAIKYTPeGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSIV 81
|
90 100
....*....|....*....|....*....
gi 1550380708 989 DRISRVLNHPVGLQSKPGKGTGFKVTVPL 1017
Cdd:smart00387 82 KKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
761-1104 |
3.99e-25 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 113.08 E-value: 3.99e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 761 ALKQANETLELRVAERTGELTRVNRELGEARAAAEEANIGKTRFFAAAGHDILQPLNAARLYSSSLVERLGDSDNRALVQ 840
Cdd:PRK11466 404 ALNRHREQLAAQVKARTAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLR 483
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 841 NIDSSLESVEAILGAVLDISRLDTGAMKPRLQSVP------LDELLRRIETDF--APMARAKDIELVImPTSLaaRSDPN 912
Cdd:PRK11466 484 AITDSGESLLTILNDILDYSAIEAGGKNVSVSDEPfeprplLESTLQLMSGRVkgRPIRLATDIADDL-PTAL--MGDPR 560
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 913 LLRRLVQNLVSNAIKYTLQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLeEGARtaSGLGLGLSIVDRIS 992
Cdd:PRK11466 561 RIRQVITNLLSNALRFTDEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQV-SGKR--GGTGLGLTISSRLA 637
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 993 RVLNHPVGLQSKPGKGTGFKVTVPLDKSAggrlkPQSVAAAKTSEALAGLNVICIDNEPKILEGMALLLGGWGCSVTTAE 1072
Cdd:PRK11466 638 QAMGGELSATSTPEVGSCFCLRLPLRVAT-----APVPKTVNQAVRLDGLRLLLIEDNPLTQRITAEMLNTSGAQVVAVG 712
|
330 340 350
....*....|....*....|....*....|..
gi 1550380708 1073 SLAACTEMAPGrlGVRPDAIIADYHLGDGTGV 1104
Cdd:PRK11466 713 NAAQALETLQN--SEPFAAALVDFDLPDYDGI 742
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
638-1022 |
7.96e-25 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 107.62 E-value: 7.96e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 638 ALQYNQDMLHTALSQMDQGIAVFDNANNLIIWNRRFRELMDLP--EAAGQvgfplaDIVAILARRGDVRKDEEKALIANF 715
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSaeELLGR------PLAELFPEDSPLRELLERALAEGQ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 716 LTLDKPFLLELAGGA-RILEVRSNAMPDK----GIVTTYTDITQRVAADMALKQAnETLELrvaerTGELtrvnrelgea 790
Cdd:COG3852 75 PVTEREVTLRRKDGEeRPVDVSVSPLRDAegegGVLLVLRDITERKRLERELRRA-EKLAA-----VGEL---------- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 791 raaaeeanigktrffaAAG--HDILQPLNAARLYSSSLVERLGDSDNRALVQNIDSSLESVEAILGAVLDISRLDtgamK 868
Cdd:COG3852 139 ----------------AAGlaHEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPR----P 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 869 PRLQSVPLDELLRRIetdfAPMARA---KDIELVI-MPTSL-AARSDPNLLRRLVQNLVSNA-----------IKYTLQG 932
Cdd:COG3852 199 PEREPVNLHEVLERV----LELLRAeapKNIRIVRdYDPSLpEVLGDPDQLIQVLLNLVRNAaeampeggtitIRTRVER 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 933 KVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVF------KEfarleegartaSGLGLGLSIVDRIsrVLNHpvG----LQ 1002
Cdd:COG3852 275 QVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFepffttKE-----------KGTGLGLAIVQKI--VEQH--GgtieVE 339
|
410 420
....*....|....*....|
gi 1550380708 1003 SKPGKGTGFKVTVPLDKSAG 1022
Cdd:COG3852 340 SEPGKGTTFRIYLPLEQAEE 359
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
801-1159 |
6.91e-24 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 108.87 E-value: 6.91e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 801 KTRFFAAAGHDILQPLNAARLYSSSLVERLGDSDNRALVQNIDSSLESVEAILGAVLDISRLDTGAMKPRLQSVPLDELL 880
Cdd:PRK11091 283 KTTFISTISHELRTPLNGIVGLSRILLDTELTAEQRKYLKTIHVSAITLGNIFNDIIDMDKMERRKLQLDNQPIDFTDFL 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 881 RRIETDFAPMARAKDIELVIMPTS---LAARSDPNLLRRLVQNLVSNAIKYTLQGKVLVGVRRH-GQTATIEVLDSGIGI 956
Cdd:PRK11091 363 ADLENLSGLQAEQKGLRFDLEPLLplpHKVITDGTRLRQILWNLISNAVKFTQQGGVTVRVRYEeGDMLTFEVEDSGIGI 442
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 957 PSSKFRTVFKEFARLEE--GARTASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPLDKSAggrlKPQSVAAAK 1034
Cdd:PRK11091 443 PEDELDKIFAMYYQVKDshGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHAPAVA----EEVEDAFDE 518
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1035 TSEALAGLNVICI-DNEPKILEGMALL--LggwGCSVTTAESLAACTEM-APGRLgvrpDAIIADYHLGDGTGVEAIAAI 1110
Cdd:PRK11091 519 DDMPLPALNILLVeDIELNVIVARSVLekL---GNSVDVAMTGKEALEMfDPDEY----DLVLLDIQLPDMTGLDIAREL 591
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1550380708 1111 RGLWQ-ESIPALM-----VTADRSpEVRGAAERDGVSlqhKPVRPAALRAWLTQL 1159
Cdd:PRK11091 592 RERYPrEDLPPLValtanVLKDKK-EYLDAGMDDVLS---KPLSVPALTAMIKKF 642
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
761-1017 |
3.40e-23 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 106.65 E-value: 3.40e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 761 ALKQANETLELRVAERTGELTRVNRElgearaaAEEANIGKTRFFAAAGHDILQPLNAArLYSSSLVERlGDSDNRALvQ 840
Cdd:PRK15347 365 TLNEQYDTLENKVAERTQALAEAKQR-------AEQANKRKSEHLTTISHEIRTPLNGV-LGALELLQN-TPLTAEQM-D 434
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 841 NIDSSLE---SVEAILGAVLDISRLDTGAMKPRLQSVPLDELLRRIETDFAPMARAKDIEL---VIMPTSLAARSDPNLL 914
Cdd:PRK15347 435 LADTARQctlSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLrtfVGAHVPLYLHLDSLRL 514
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 915 RRLVQNLVSNAIKYTLQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEgarTASGLGLGLSIVDRISRV 994
Cdd:PRK15347 515 RQILVNLLGNAVKFTETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT---HSQGTGLGLTIASSLAKM 591
|
250 260
....*....|....*....|...
gi 1550380708 995 LNHPVGLQSKPGKGTGFKVTVPL 1017
Cdd:PRK15347 592 MGGELTLFSTPGVGSCFSLVLPL 614
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
666-1017 |
1.56e-22 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 100.64 E-value: 1.56e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 666 LIIWNRRFRELMDLPEAAGQVGFPLADIVAILARRGDVRKDEEKALIANFLTLDKPFLLELAGGARILEVRSNAMPDKGI 745
Cdd:COG4191 30 LLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAEL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 746 VTTYTDITQRVAADMALKQANEtlELRVAERT---GELTrvnrelgearaaaeeanigktrffAAAGHDILQPLNAARLY 822
Cdd:COG4191 110 EELERDITELERAEEELRELQE--QLVQSEKLaalGELA------------------------AGIAHEINNPLAAILGN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 823 SSSLVERLGDSDNRA----LVQNIDSSLESVEAILGAVLDISRLDTGAMKPrlqsVPLDELLRRIETDFAPMARAKDIEL 898
Cdd:COG4191 164 AELLRRRLEDEPDPEelreALERILEGAERAAEIVRSLRAFSRRDEEEREP----VDLNELIDEALELLRPRLKARGIEV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 899 V--IMPTSLAARSDPNLLRRLVQNLVSNAI---KYTLQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVF------KE 967
Cdd:COG4191 240 EldLPPDLPPVLGDPGQLEQVLLNLLINAIdamEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFepffttKP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1550380708 968 farleegarTASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPL 1017
Cdd:COG4191 320 ---------VGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
910-1019 |
2.25e-22 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 93.20 E-value: 2.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 910 DPNLLRRLVQNLVSNAIKYTLQ-GKVLVGVRRHGQtATIEVLDSGIGIPSSKFRTVFKEFARLEegARTASGLGLGLSIV 988
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKaGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTAD--KRGGGGTGLGLSIV 78
|
90 100 110
....*....|....*....|....*....|.
gi 1550380708 989 DRISRVLNHPVGLQSKPGKGTGFKVTVPLDK 1019
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
810-1017 |
3.90e-21 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 97.75 E-value: 3.90e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 810 HDILQPLnaARL-YSSSLVERLGDSDNRALVQNIDSslesVEAILGAVLDISRLDTGAMKPRLQSVPLDELLRRIETDFA 888
Cdd:PRK10604 221 HELRTPL--VRLrYRLEMSDNLSAAESQALNRDIGQ----LEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQ 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 889 PMARAKDIELVIMPTSLAARSDPNLLRRLVQNLVSNAIKYTlQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEF 968
Cdd:PRK10604 295 AVTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALRYA-HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPF 373
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1550380708 969 ARLEEG-ARTASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPL 1017
Cdd:PRK10604 374 VRLDPSrDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
799-1159 |
5.83e-21 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 99.81 E-value: 5.83e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 799 IGKTRFFAAAGHDILQPLNAA----RLYSSSLVERLGDSDNRALVQnidSSLESVEAILGAVLDISRLDTGAMKPRLQSV 874
Cdd:PRK09959 710 VAKSQFLATMSHEIRTPISSImgflELLSGSGLSKEQRVEAISLAY---ATGQSLLGLIGEILDVDKIESGNYQLQPQWV 786
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 875 PLDELLRRIETDFAPMARAKDIELV---IMPTSLAARSDPNLLRRLVQNLVSNAIKYTLQGKV-----LVGVRRHGQTAT 946
Cdd:PRK09959 787 DIPTLVQNTCHSFGAIAASKSIALScssTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAVkittsLGHIDDNHAVIK 866
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 947 IEVLDSGIGIPSSKFRTVFKEFARLEEGaRTASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPLDKSaggrlk 1026
Cdd:PRK09959 867 MTIMDSGSGLSQEEQQQLFKRYSQTSAG-RQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEIS------ 939
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1027 pQSVAA--AKTSEALA---GLNVICIDNEP--KILEGMALLLGGWGCSVTTaESLAACTEMAPGRLgvrpDAIIADYHLG 1099
Cdd:PRK09959 940 -QQVATveAKAEQPITlpeKLSILIADDHPtnRLLLKRQLNLLGYDVDEAT-DGVQALHKVSMQHY----DLLITDVNMP 1013
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1550380708 1100 DGTGVEAIAAIRGlWQESIPALMVTADRSPEVRGAAERDGVSL-QHKPVRPAALRAWLTQL 1159
Cdd:PRK09959 1014 NMDGFELTRKLRE-QNSSLPIWGLTANAQANEREKGLSCGMNLcLFKPLTLDVLKTHLSQL 1073
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
914-1017 |
1.23e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 88.32 E-value: 1.23e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 914 LRRLVQNLVSNAIKYTLQGKVLVGVRRHGQTAT-----IEVLDSGIGIPSSKFRTVFKEFARLEEGA-RTASGLGLGLSI 987
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGEVTLRVSLEEEEEDgvqlrFSVEDTGIGIPEEQQARLFEPFSQADSSTtRKYGGTGLGLAI 80
|
90 100 110
....*....|....*....|....*....|
gi 1550380708 988 VDRISRVLNHPVGLQSKPGKGTGFKVTVPL 1017
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
840-1079 |
2.44e-19 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 94.15 E-value: 2.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 840 QNIDSSLESVEAILGAVLDISRLDTGAMKprLQSVP--LDELLRRIETDFAPMARAKDIELVI-----MPTSLAArsDPN 912
Cdd:PRK11107 332 QTIERSANNLLAIINDILDFSKLEAGKLV--LENIPfsLRETLDEVVTLLAHSAHEKGLELTLnidpdVPDNVIG--DPL 407
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 913 LLRRLVQNLVSNAIKYTLQGKVLVGVRRHGQTAT-----IEVLDSGIGIPSSKFRTVFKEFarleeGARTAS------GL 981
Cdd:PRK11107 408 RLQQIITNLVGNAIKFTESGNIDILVELRALSNTkvqleVQIRDTGIGISERQQSQLFQAF-----RQADASisrrhgGT 482
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 982 GLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPLDKSaggrlkPQSVAAAKTSEALAGLNVICIdnEPKILEGMALL- 1060
Cdd:PRK11107 483 GLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPLDLN------PNPIIDGLPTDCLAGKRLLYV--EPNSAAAQATLd 554
|
250 260
....*....|....*....|
gi 1550380708 1061 -LGGWGCSVTTAESLAACTE 1079
Cdd:PRK11107 555 iLSETPLEVTYSPTLSQLPE 574
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
810-1018 |
3.72e-18 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 89.13 E-value: 3.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 810 HDILQPLNAARLYSSSLVERLGDSDNRALVQNIDSSLESVEAILGAVLDISRLDTGAMKPRLQSVPLDELLRRIETDFAP 889
Cdd:PRK11100 265 HELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREA 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 890 MARAKDIELVIMPTSLAARSDPNLLRRLVQNLVSNAIKYTLQG-KVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEF 968
Cdd:PRK11100 345 QAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGgTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERF 424
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1550380708 969 ARLeegARTASGL---GLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPLD 1018
Cdd:PRK11100 425 YSL---PRPANGRkstGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
|
|
| CheY |
COG0784 |
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ... |
1038-1159 |
3.54e-17 |
|
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];
Pssm-ID: 440547 [Multi-domain] Cd Length: 128 Bit Score: 78.74 E-value: 3.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1038 ALAGLNVICIDNEPKILEGMALLLGGWGCSVTTAESLAACTEMAPGRlgvRPDAIIADYHLGDGTGVEAIAAIRGLWQ-E 1116
Cdd:COG0784 2 PLGGKRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAG---PPDLILLDINMPGMDGLELLRRIRALPRlP 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1550380708 1117 SIPALMVTADRSPEVRGAAERDGVS-LQHKPVRPAALRAWLTQL 1159
Cdd:COG0784 79 DIPIIALTAYADEEDRERALEAGADdYLTKPVDPEELLEALRRL 122
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
910-1013 |
1.19e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 77.06 E-value: 1.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 910 DPNLLRRLVQNLVSNAIKYTLQGKVlVGVRRHGQ-TATIEVLDSGIGIPSSKFRTVFKEFARLEegARTASGLGLGLSIV 988
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSR-VEIKLSADdGAVIRVEDNGPGIDEEELEALFERFYRSD--GQNYGGSGLGLSIV 86
|
90 100
....*....|....*....|....*
gi 1550380708 989 DRISRVLNHPVGLQSKPGKGTGFKV 1013
Cdd:cd16940 87 KRIVELHGGQIFLGNAQGGGLEAWV 111
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
636-1023 |
1.41e-16 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 84.63 E-value: 1.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 636 SEALQYNQDMLHTalsqMDQGIAVFDNANNLIIWNRRFRELMDLP--EAAGQ-------VGFPLADIVAILARRGDvrkd 706
Cdd:PRK11360 258 RETRSLNELILES----IADGVIAIDRQGKITTMNPAAEVITGLQrhELVGKpyselfpPNTPFASPLLDTLEHGT---- 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 707 EEKALIANFLTLDKPFLLeLAGGARILEVRSNAMpdkGIVTTYTDITQRVAADMALKQANetlelRVAErTGELTrvnre 786
Cdd:PRK11360 330 EHVDLEISFPGRDRTIEL-SVSTSLLHNTHGEMI---GALVIFSDLTERKRLQRRVARQE-----RLAA-LGELV----- 394
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 787 lgearaaaeeanigktrffAAAGHDILQPLNAARLYSSSLVERLGDSDNRALVQNIDSSLESVEAILGAVLDISRldtgA 866
Cdd:PRK11360 395 -------------------AGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSR----P 451
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 867 MKPRLQSVPLDELLRRIeTDFAPMARAKD---IELVIMPTSLAARSDPNLLRRLVQNLVSNAIK-YTLQGKVLVGVRRHG 942
Cdd:PRK11360 452 RESQWQPVSLNALVEEV-LQLFQTAGVQArvdFETELDNELPPIWADPELLKQVLLNILINAVQaISARGKIRIRTWQYS 530
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 943 QT-ATIEVLDSGIGIPSSKFRTVFKEFARLEegartASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPLDKSA 1021
Cdd:PRK11360 531 DGqVAVSIEDNGCGIDPELLKKIFDPFFTTK-----AKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQG 605
|
..
gi 1550380708 1022 GG 1023
Cdd:PRK11360 606 NQ 607
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
808-991 |
6.34e-16 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 81.88 E-value: 6.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 808 AG--HDILQPLNAARLYSSSLVErlGDSdnrALVQNIDSSLESVEAILGAVLDISRLDTgamKPRLQSVPLDELLRriET 885
Cdd:PRK09467 234 AGvsHDLRTPLTRIRLATEMMSE--EDG---YLAESINKDIEECNAIIEQFIDYLRTGQ---EMPMEMADLNALLG--EV 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 886 DFAPMARAKDIELVIMPTSLAARSDPNLLRRLVQNLVSNAIKYTlQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVF 965
Cdd:PRK09467 304 IAAESGYEREIETALQPGPIEVPMNPIAIKRALANLVVNAARYG-NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLF 382
|
170 180
....*....|....*....|....*.
gi 1550380708 966 KEFARLEEgARTASGLGLGLSIVDRI 991
Cdd:PRK09467 383 QPFTRGDS-ARGSSGTGLGLAIVKRI 407
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
803-1015 |
8.44e-16 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 81.62 E-value: 8.44e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 803 RFFAAAGHDILQPLNAARLYSSslVERLGDSD----NRALvQNIDSSLESVEAILGAVLDISRLDTGAMKPRLQSVPLDE 878
Cdd:PRK10337 239 RFTSDAAHELRSPLAALKVQTE--VAQLSDDDpqarKKAL-LQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLED 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 879 LLRRIETDFAPMARAKDIELVI-MPTSLAARS-DPNLLRRLVQNLVSNAIKYTLQGKVlVGVRRHGQtaTIEVLDSGIGI 956
Cdd:PRK10337 316 LLQSAVMDIYHTAQQAGIDVRLtLNAHPVIRTgQPLLLSLLVRNLLDNAIRYSPQGSV-VDVTLNAR--NFTVRDNGPGV 392
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1550380708 957 PSSKFRTVFKEFARleEGARTASGLGLGLSIVDRISRVLNHPVGLQSKPGKgtGFKVTV 1015
Cdd:PRK10337 393 TPEALARIGERFYR--PPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEG--GFEAKV 447
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
914-1016 |
1.33e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 73.52 E-value: 1.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 914 LRRLVQNLVSNAIKYTLQG---KVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLeEGARTASGLGLGLSIVDR 990
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRrppRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRL-HSREEYEGTGVGLAIVRK 79
|
90 100
....*....|....*....|....*.
gi 1550380708 991 ISRVLNHPVGLQSKPGKGTGFKVTVP 1016
Cdd:cd16921 80 IIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
637-1024 |
1.57e-14 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 77.71 E-value: 1.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 637 EALQYNQDMLHTALSQMDQGIAVFDNANNLIIWNRRFRELMDLPEAA--GQVG---FPLADIVAILARRGDVRKDEEKA- 710
Cdd:COG5809 134 EALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEEliGKSIlelIHSDDQENVAAFISQLLKDGGIAq 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 711 LIANFLTLDKpfllelaggaRILEVRSNAMPDK------GIVTTYTDITQRvaadmalKQANEtlELRVAERT---GELt 781
Cdd:COG5809 214 GEVRFWTKDG----------RWRLLEASGAPIKkngevdGIVIIFRDITER-------KKLEE--LLRKSEKLsvvGEL- 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 782 rvnrelgearaaaeeanigktrffaAAG--HDILQPLNAARLYSSSLVERLgDSDNRALVQNIDSSLESVEAILGAVLDI 859
Cdd:COG5809 274 -------------------------AAGiaHEIRNPLTSLKGFIQLLKDTI-DEEQKTYLDIMLSELDRIESIISEFLVL 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 860 SRLDTGAMKPrlqsVPLDELLRRIETDFAPMARAKDIELVI-----MPTSLAarsDPNLLRRLVQNLVSNAIKYT-LQGK 933
Cdd:COG5809 328 AKPQAIKYEP----KDLNTLIEEVIPLLQPQALLKNVQIELeleddIPDILG---DENQLKQVFINLLKNAIEAMpEGGN 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 934 VLVGVRRHGQTA-TIEVLDSGIGIPSSKFRTVFKEFARLEEGartasGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFK 1012
Cdd:COG5809 401 ITIETKAEDDDKvVISVTDEGCGIPEERLKKLGEPFYTTKEK-----GTGLGLMVSYKIIEEHGGKITVESEVGKGTTFS 475
|
410
....*....|..
gi 1550380708 1013 VTVPLDKSAGGR 1024
Cdd:COG5809 476 ITLPIKLSEQVS 487
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
909-1016 |
2.23e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 70.39 E-value: 2.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 909 SDPNLLRRLVQNLVSNAIKYTLQ-GKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEGARTASGLGLGLSI 987
Cdd:cd16948 1 TDAKWLSFIIGQIVSNALKYSKQgGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80
|
90 100
....*....|....*....|....*....
gi 1550380708 988 VDRISRVLNHPVGLQSKPGKGTGFKVTVP 1016
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
8-464 |
2.55e-14 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 76.78 E-value: 2.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 8 FASAFAYLLLLFAVASYGDRRARRNE---IAakGR---PLVYALSL-AIYCTSWTYFGGVGLAAERGLE----FTGIYIG 76
Cdd:cd11475 1 LITFIVYLLLMLGIGIYSYRKTKTLEdyfLG--GRslgPWVTALSAgASDMSGWLLLGLPGAAYASGLSaiwiAIGLILG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 77 PILMFTLgmpLIRRIVRLAKTEKLTSVADFVAARYG-KNPAVAAIVALISLVGAIPYIALQLKAVSSSVATMIDTsDYGI 155
Cdd:cd11475 79 AYLNWLF---VAKRLRRYTEKNDSITLPDYLENRFRdKSKLLRILSALIILIFFTIYAAAQLVAGGKLFESLFGI-DYST 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 156 GsgenfvdlpllvtLFLACFAIVFGTrhtdATehqdGLILAIAM----ESVVKLVAMLTVGVYIVFVLfGGPA------- 224
Cdd:cd11475 155 G-------------LLIGAVVVVAYT----FL----GGFLAVSWtdffQGLLMLLALVLVPIVALAAL-GGLSglvaala 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 225 -------NLWAEAQQSATVIAALeyqtpvarWILMIALSAFGiimlprQFHVTV--VENRTDNELRTAGILFPLYLIAIN 295
Cdd:cd11475 213 aidpgllSPFGGDLGAGGLLAII--------SLLAWGLGYFG------QPHILVrfMAIRSPKEIKKARRIAMVWMILFL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 296 AFVLPIAIAGILTFSGSGNADLYLLALPLAGDVplvtLFTFIGGF----------SAATAMVIVASVALSimvsNDIvMP 365
Cdd:cd11475 279 LGAVLVGLLGRALFPDGLLGDPETVFPVLAQEL----FPPWLAGIllaailaaimSTADSQLLVCSSALT----EDL-YK 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 366 VFLRRRLGTRgslqedmagTLLNIRRTAIFVVLFLGYGYyrAADISAGLASLGLLSFAAI-AQMAPALLGGLVWRQANAR 444
Cdd:cd11475 350 AFLRKEASDK---------ELVWVSRLAVLVIALIALLI--ALNPPSSVFSLVSFAWAGLgAAFGPLLLLSLYWKRTTRQ 418
|
490 500
....*....|....*....|...
gi 1550380708 445 GAIAGMVSGF---LVWAYVLFLP 464
Cdd:cd11475 419 GALAGMIAGAvtvVVWKLLGLGI 441
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
801-1016 |
4.44e-14 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 75.37 E-value: 4.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 801 KTRFFAAAGHDILQPLNAARLYSSSLVERLGDSDNRALVQNID-------SSLESVEAILGAVLDISRLDTGAMKPRLQS 873
Cdd:PRK09303 151 KDRVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPALIEqlqdqarRQLEEIERLITDLLEVGRTRWEALRFNPQK 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 874 VPLDELLRRIETDFAPMARAKDIELVI-MPTSL-AARSDPNLLRRLVQNLVSNAIKYT-LQGKV-LVGVRRHGQTATIEV 949
Cdd:PRK09303 231 LDLGSLCQEVILELEKRWLAKSLEIQTdIPSDLpSVYADQERIRQVLLNLLDNAIKYTpEGGTItLSMLHRTTQKVQVSI 310
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1550380708 950 LDSGIGIPSSKFRTVFKEFARLEEGARTaSGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVP 1016
Cdd:PRK09303 311 CDTGPGIPEEEQERIFEDRVRLPRDEGT-EGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| REC |
cd00156 |
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ... |
1047-1141 |
1.53e-13 |
|
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.
Pssm-ID: 381085 [Multi-domain] Cd Length: 99 Bit Score: 67.64 E-value: 1.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1047 IDNEPKILEGMALLLGGWGCSVTTAESLAACTEMApgrLGVRPDAIIADYHLGDGTGVEAIAAIRGLwQESIPALMVTAD 1126
Cdd:cd00156 3 VDDDPAIRELLKSLLEREGYEVDTAADGEEALELL---REERPDLVLLDLMMPGMDGLELLRKLREL-PPDIPVIVLTAK 78
|
90
....*....|....*
gi 1550380708 1127 RSPEVRGAAERDGVS 1141
Cdd:cd00156 79 ADEEDAVRALELGAD 93
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
914-1016 |
1.72e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 67.47 E-value: 1.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 914 LRRLVQNLVSNAIKYTlQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEgARTASGLGLGLSIVDRISR 993
Cdd:cd16950 1 LKRVLSNLVDNALRYG-GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDN-ARGTSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|...
gi 1550380708 994 VLNHPVGLQSKPGKGTGFKVTVP 1016
Cdd:cd16950 79 AHGGSLTLANRAGGGLCARIELP 101
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
612-1020 |
4.62e-13 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 72.57 E-value: 4.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 612 LVLSLVLQRMDDTSSDTAWLLDQASEALQYNQDMLHTalsqMDQGIAVFDNANNLIIWNRRFRELMDLPEaagqVGFPLA 691
Cdd:COG3290 56 LLLILLLLLLLLLAALLLKLLEEIARLVEEREAVLES----IREGVIAVDRDGRITLINDAARRLLGLDA----IGRPID 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 692 DIVAILARRGDVRKdeekalianfltldkpfllELAGGARILEVRSNAMPDK----GIVTTYTDITQrvaadmaLKQANE 767
Cdd:COG3290 128 EVLAEVLETGERDE-------------------EILLNGRVLVVNRVPIRDDgrvvGAVATFRDRTE-------LERLEE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 768 tlELRVAERTGELTRVNRelgearaaaeeanigktrffaaagHDILQPLNAArlysSSLVErLGDSDnrALVQNIDSSLE 847
Cdd:COG3290 182 --ELEGVKELAEALRAQR------------------------HDFRNHLHTI----SGLLQ-LGEYD--EALEYIDEISE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 848 SVEAILGAVLDisrldtgamkpRLQSVPLDELLrrieTDFAPMARAKDIELVIMPTSL--AARSDPNLLRRLVQNLVSNA 925
Cdd:COG3290 229 ELQELIDSLLS-----------RIGNPVLAALL----LGKAARARERGIDLTIDIDSDlpDLPLSDTDLVTILGNLLDNA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 926 IKYTLQ-----GKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFkefarlEEGART--ASGLGLGLSIVDRISRVLNHP 998
Cdd:COG3290 294 IEAVEKlpeeeRRVELSIRDDGDELVIEVEDSGPGIPEELLEKIF------ERGFSTklGEGRGLGLALVKQIVEKYGGT 367
|
410 420
....*....|....*....|..
gi 1550380708 999 VGLQSKPGKGTGFKVTVPLDKS 1020
Cdd:COG3290 368 IEVESEEGEGTVFTVRLPKEGE 389
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
895-1015 |
4.76e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 67.15 E-value: 4.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 895 DIELVIMPTSLAARSDPNLLRRLVQNLVSNAIKYTLQGKVLVGVRRHGQT-ATIEVLDSGIGIPSSKFRTVFKEFARLEE 973
Cdd:cd16947 2 QVEINIPDRPIYANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKhVYIDIWDKGKGISETEKDHVFERLYTLED 81
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1550380708 974 GARTA-SGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTV 1015
Cdd:cd16947 82 SRNSAkQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| RpfG |
COG3437 |
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ... |
1042-1154 |
7.71e-13 |
|
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];
Pssm-ID: 442663 [Multi-domain] Cd Length: 224 Bit Score: 69.04 E-value: 7.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1042 LNVICIDNEPKILEGMALLLGGWGCSVTTAESLAACTEMApgrLGVRPDAIIADYHLGDGTGVEAIAAIRGLWQ-ESIPA 1120
Cdd:COG3437 7 PTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELL---LEAPPDLILLDVRMPGMDGFELLRLLRADPStRDIPV 83
|
90 100 110
....*....|....*....|....*....|....*
gi 1550380708 1121 LMVTADRSPEVRGAAERDGVS-LQHKPVRPAALRA 1154
Cdd:COG3437 84 IFLTALADPEDRERALEAGADdYLTKPFDPEELLA 118
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
914-1016 |
2.56e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 64.53 E-value: 2.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 914 LRRLVQNLVSNAIKYTLQG-KVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLE-EGARTASGLGLGLSIVdri 991
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSdTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDiERCRNTGGTGLGLAIV--- 77
|
90 100
....*....|....*....|....*...
gi 1550380708 992 SRVLNH---PVGLQSKPGKGTGFKVTVP 1016
Cdd:cd16952 78 KHVMSRhdaRLLIASELGKGSRFTCLFP 105
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
803-991 |
4.15e-12 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 69.23 E-value: 4.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 803 RFFAA-AGHDILQPLNAARLySSSLVERLGDSDNRALVQNIDSSLESVEAILgavlDISRLDTGAMKPRLQSVPL-DELL 880
Cdd:PRK10755 138 RLFTAdVAHELRTPLAGIRL-HLELLEKQHHIDVAPLIARLDQMMHTVEQLL----QLARAGQSFSSGHYQTVKLlEDVI 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 881 RRIETDFAPMA--RAKDIELVIMPTSLAARSDPNLLRRLVQNLVSNAIKYTLQG-KVLVGVRRHGQTATIEVLDSGIGIP 957
Cdd:PRK10755 213 LPSQDELSEMLeqRQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGsTITIKLSQEDGGAVLAVEDEGPGID 292
|
170 180 190
....*....|....*....|....*....|....
gi 1550380708 958 SSKFRTVFKEFARLEegaRTASGLGLGLSIVDRI 991
Cdd:PRK10755 293 ESKCGELSKAFVRMD---SRYGGIGLGLSIVSRI 323
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
81-518 |
4.21e-12 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 69.84 E-value: 4.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 81 FTLGMPLIRRIV--RLAKTEKLTsVADFVAARYGkNPAVAAIVALISLVGAIPYIALQLKAVSSSVATMIDTsDYGIGSg 158
Cdd:cd11480 75 WTGGYVLLLLLVaePLRNFGKYT-VPDFLGARLG-SRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGI-PYEVGV- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 159 enfvdlpLLVTLFLACFAIVFGTRHTDATEhqdglilaiAMESVVKLVAMLtVGVYIVFVLFGGPA-----NLWAEAQQS 233
Cdd:cd11480 151 -------VVVGALMIVYVVLGGMRATTWVQ---------IIQYVLLLGAFL-VPAILVLARFGGNPlgagpGLLGLAAAA 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 234 ATVIAA------LEYQTPVARWILMIALsAFGIIMLP----RQFHV-TVVENRTdNELRTAGILFPLYLIAI------NA 296
Cdd:cd11480 214 ASGAGEaylapgLLLTDPLDVISLTLAL-MLGTAGLPhvlmRFYTVpDARAARK-SVVWALGFIGLFYLLAPalgfgaRA 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 297 FVLPIAIAGILTFSGSGNADLYLLALPLAGDVPLVtLFTFIGGFSAATAMVIVASVALSI--MVSNDIvmpvfLRRRLGT 374
Cdd:cd11480 292 LVGPDVIGAPIAGELDGGGDMAVLLLPEIAGLGDL-LLALVAAGAFAAILATVAGLLLAAasALAHDL-----YAGVIRP 365
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 375 RGSLQEDMAgtllnIRRTAIFVVLFLGyGYYRAADISAGLASLGLLSFA-AIAQMAPALLGGLVWRQANARGAIAGMVSG 453
Cdd:cd11480 366 GASERREVR-----VARIAAVVVGVIA-ILLALLFPPQNVAFLVALAFAiAASAFFPVLVLGIFWRRFTTRGAIAGMLVG 439
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1550380708 454 FLV-WAYVLFLPSLGGPDNSHiastvlsFLLPFtdlfsgaqsdPLVNATALSMLVNVAAYIVGSLT 518
Cdd:cd11480 440 LLVsLVLIVLSPAVSGAPPGH-------DFAGF----------PLTNPGLVSVPLGFLVAIVVSLL 488
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
857-1019 |
1.73e-11 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 68.91 E-value: 1.73e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 857 LDISRLDTGAMKPRLQSVPLDEL----LRRIEtdfaPMARAKDIELVIMPTSLAARSDPNLLRRLVQNLVSNAIKYT-LQ 931
Cdd:PRK10490 722 LDMARIQSGGFNLRKEWLTLEEVvgsaLQMLE----PGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAgAQ 797
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 932 GKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFAR-LEEGArtASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTG 1010
Cdd:PRK10490 798 AEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARgNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGAC 875
|
....*....
gi 1550380708 1011 FKVTVPLDK 1019
Cdd:PRK10490 876 FRVTLPLET 884
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
637-1017 |
3.25e-11 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 67.06 E-value: 3.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 637 EALQYNQDMLHTALSQMDQGIAVFDNANNLIIWNRRFRELMDLPEAAgQVG------FPLADIVAILAR-RGDVRKDEEK 709
Cdd:COG5805 150 EILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREE-LIGknllelLHPCDKEEFKERiESITEVWQEF 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 710 ALIANFLTLD-KPFLLElaggARILEVRSNAMPDKGIVTTYTDITQRvaadmalKQANETL----ELRVAertGELTrvn 784
Cdd:COG5805 229 IIEREIITKDgRIRYFE----AVIVPLIDTDGSVKGILVILRDITEK-------KEAEELMarseKLSIA---GQLA--- 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 785 relgearaaaeeanigktrffAAAGHDILQPLNAARLYSSSLveRLGDSDNRALVQNIDSSLESVEAILGAVLDISRLDT 864
Cdd:COG5805 292 ---------------------AGIAHEIRNPLTSIKGFLQLL--QPGIEDKEEYFDIMLSELDRIESIISEFLALAKPQA 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 865 gamkPRLQSVPLDELLRRIETDFAPMARAKDIELVIMPTSLAARS--DPNLLRRLVQNLVSNAIKYTLQ-GKVLVGVRRH 941
Cdd:COG5805 349 ----VNKEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIycDENQIKQVFINLIKNAIEAMPNgGTITIHTEEE 424
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1550380708 942 GQTATIEVLDSGIGIPSSKFRTVFKEFARLEEgartaSGLGLGLSIVDRIsrVLNHPVGLQ--SKPGKGTGFKVTVPL 1017
Cdd:COG5805 425 DNSVIIRVIDEGIGIPEERLKKLGEPFFTTKE-----KGTGLGLMVSYKI--IENHNGTIDidSKVGKGTTFTITLPL 495
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
81-525 |
3.96e-11 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 67.10 E-value: 3.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 81 FTLGMPLIRRIV--RLAKTEKLTsVADFVAARYGKNPA--VAAIVAL-ISLVgaipYIALQLKAVSSSVATMIDtSDYGI 155
Cdd:COG4147 89 WLVGYVLLLLLLaeYLRNFGKFT-VPDFLGDRFYSRPArlVAAISTLvVSFF----YLIAQMVGAGVLISLLLG-VDYEV 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 156 GsgenfvdlPLLVTLFLACFAIVFGTRHTDATEhqdglilaiAMESVVKLVAmLTVGVYIVFVLFGG-PANLWAEAqqSA 234
Cdd:COG4147 163 A--------VVIVGVLMIVYVVLGGMKGTTWVQ---------IIKAVLLIFA-YTVPAVLVLAQFGFnPLPLLAKA--AE 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 235 TVIAALEYQTPVARWI-------LMIALsAFGIIMLP----RQFHV-TVVENRtdnelRTAGilFPLYLIAINAFVLPIA 302
Cdd:COG4147 223 VHDLGAAYLEPGGLVKspldfisLGLAL-MLGTAGLPhilmRFFTVpDAKEAR-----KSVG--WALGFIGLFYLTAPAL 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 303 IAGILTFSGS--------------GNADLYLLALPLAGDVPLVtLFTFI--GGFsaATAMVIVASVALSI--MVSNDIVM 364
Cdd:COG4147 295 GFGARALVGPlpewfdtgligaadGGGNMAVLALAEIAGGGNW-LLGLVaaGAF--ATILAVVAGLLLAIasAISHDLYA 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 365 PVFlRRRLGTRgslQEDMAGtllniRRTAIFVVLFLGYG--YYRAADIsAGLASLGLlSFAAIAQMaPALLGGLVWRQAN 442
Cdd:COG4147 372 NVI-KGKATEK---EELRVA-----RIAAVVIGVVAILLgiNAPPQNV-AFLVALAF-ALAASANF-PVLLLSIFWKRFN 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 443 ARGAIAGMVSGFLVW-AYVLFLPSLGGPDNSHiastvlsfllpftDLFsgaqsdPLVNATALSMLVNVAAYIVGSLTRAP 521
Cdd:COG4147 440 TRGAVAGMLVGLISAlVLIVLSPFVWVLGVDA-------------ALF------PLENPGLVSMPLGFLVAIVVSLLTPE 500
|
....
gi 1550380708 522 KPLE 525
Cdd:COG4147 501 PPAE 504
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
759-1016 |
4.50e-11 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 66.57 E-value: 4.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 759 DMALKQANeTLELRVAERT-GELTRVNRELGEARAAAeeaniGKTR-FFAAAGHDILQPLNAARLYssslVERLGDSD-- 834
Cdd:PRK11006 166 TLVLNNGR-HLEIRVMPYTeGQLLMVARDVTQMHQLE-----GARRnFFANVSHELRTPLTVLQGY----LEMMQDQPle 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 835 ----NRALvQNIDSSLESVEAILGAVLDISRLDTGAMKPRLQSVPLDELLRRIETDFAPMARAK-DIELVIMPtSLAARS 909
Cdd:PRK11006 236 galrEKAL-HTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLEREAQTLSQGKhTITFEVDN-SLKVFG 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 910 DPNLLRRLVQNLVSNAIKYTLQG-KVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEG-ARTASGLGLGLSI 987
Cdd:PRK11006 314 NEDQLRSAISNLVYNAVNHTPEGtHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKArSRQTGGSGLGLAI 393
|
250 260 270
....*....|....*....|....*....|..
gi 1550380708 988 VdriSRVLNH---PVGLQSKPGKGTGFKVTVP 1016
Cdd:PRK11006 394 V---KHALSHhdsRLEIESEVGKGTRFSFVLP 422
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
910-1016 |
6.31e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 60.55 E-value: 6.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 910 DPNLLRRLVQNLVSNAIKYTLQGKVL-VGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEGARTAS-GLGLGLSI 987
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLrIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASgGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 1550380708 988 VDRISRVLNHPVGLQSKPGKGTGFKVTVP 1016
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| CitB |
COG4565 |
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ... |
1042-1159 |
6.93e-11 |
|
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];
Pssm-ID: 443622 [Multi-domain] Cd Length: 138 Bit Score: 61.14 E-value: 6.93e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1042 LNVICIDNEPKILEGMALLL---GGWGCsVTTAESLAACTEMAPGRlgvRPDAIIADYHLGDGTGVEAIAAIRGLwQESI 1118
Cdd:COG4565 4 IRVLIVEDDPMVAELLRRYLerlPGFEV-VGVASSGEEALALLAEH---RPDLILLDIYLPDGDGLELLRELRAR-GPDV 78
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1550380708 1119 PALMVTADRSPEVRGAAERDGVS--LqHKPVRPAALRAWLTQL 1159
Cdd:COG4565 79 DVIVITAARDPETVREALRAGVVdyL-IKPFTFERLREALERY 120
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
807-1028 |
1.68e-10 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 64.81 E-value: 1.68e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 807 AAG--HDILQPLNAARLYSSSLVERL-GDSDNRALVQNIDSSLESVEAILGAVLDISRldtgAMKPRLQSVPLDEL---- 879
Cdd:PRK10364 241 AAGvaHEIRNPLSSIKGLAKYFAERApAGGEAHQLAQVMAKEADRLNRVVSELLELVK----PTHLALQAVDLNDLinhs 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 880 LRRIETDfapmARAKDIEL--VIMPTSLAARSDPNLLRRLVQNLVSNAIKYTLQGKVL-VGVRRHGQTATIEVLDSGIGI 956
Cdd:PRK10364 317 LQLVSQD----ANSREIQLrfTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVIsVTASESGAGVKISVTDSGKGI 392
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1550380708 957 PSSKFRTVFKEFARLEegartASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPLDksaGGRLKPQ 1028
Cdd:PRK10364 393 AADQLEAIFTPYFTTK-----AEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVN---ITRRDPQ 456
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
801-1035 |
1.83e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 65.38 E-value: 1.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 801 KTRFFAAAGHDILQPL-----NAARLYSSSL---VERLGDSDNRAlvqnidSSLesVEAILGAVLDISRLDTGAMK---- 868
Cdd:PRK10841 447 KSMFLATVSHELRTPLygiigNLDLLQTKELpkgVDRLVTAMNNS------SSL--LLKIISDILDFSKIESEQLKiepr 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 869 ---PRlqsvpldELLRRIETDFAPMARAKDIEL--VIMP-TSLAARSDPNLLRRLVQNLVSNAIKYTLQGKVLVGVRRHG 942
Cdd:PRK10841 519 efsPR-------EVINHITANYLPLVVKKRLGLycFIEPdVPVALNGDPMRLQQVISNLLSNAIKFTDTGCIVLHVRVDG 591
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 943 QTATIEVLDSGIGIPSSKFRTVFKEFARLEEGARTAS-GLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPLDKSA 1021
Cdd:PRK10841 592 DYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFqGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPLYGAQ 671
|
250
....*....|....
gi 1550380708 1022 GGRLKPQSVAAAKT 1035
Cdd:PRK10841 672 YPQKKGVEGLQGKR 685
|
|
| SLC5sbd_CHT |
cd11474 |
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ... |
12-484 |
2.61e-10 |
|
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271368 [Multi-domain] Cd Length: 464 Bit Score: 64.08 E-value: 2.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 12 FAYLLLLFAVASYGDRRARR-NEIAAKGRPLvyALSLAIYCTSWTYFGG------VGLAAERGLeftgiyIGPILM-FTL 83
Cdd:cd11474 5 ILYYLLILGIGLWASRRVKSsEDFLLAGRSL--PLPVGVFTLFATWFGGetilgaAETFYEEGL------GGVAQDpFGY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 84 GMPLI-------RRIVRLakteKLTSVADFVAARYGKnpAVAAIVALISLVGAIPYIALQLKAVSSSVATmidtsdygig 156
Cdd:cd11474 77 ALCLIlgglffaKPMRRM----GLLTLGDFFRQRYGR--RVEVLLSIPAVLSYLGWVAAQLVALGLVLSV---------- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 157 sgenFVDLPLLVTLFLACFAIVFGTRHtdatehqdGLILAIAMESVVKLVAMLtVG-VYIVFVLFGGPANLWAEAQQSAT 235
Cdd:cd11474 141 ----ILGLPVETGILISAAIVLAYTLF--------GGMWSVAYTDVVQLIVIF-VGlLVLVPFVLTNPGGVDIASAAAAG 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 236 VIAALEYQTPVARWILMIAlsAFGIIML---PRQ-FHVTVVENRTDNELRTAGIL----------FPLYLIAINAFVLPi 301
Cdd:cd11474 208 KLRFFPWLGTKSDWLIWID--AWLTLGLgsiPQQdVFQRVLSAKSEKTAQRLSLLagvgyllfaiPPLLIGLAAASIDP- 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 302 aiaGILTFSGSGNADLYLLALpLAGDVPLVTLFTFIGGFSAATaMVIVASVAL--SIMVSNDIVMPVFLRRRLGTRgslq 379
Cdd:cd11474 285 ---SLTQYGLEEDAQLILPLL-LQYLTPLWVQVLFLGALLSAV-MSTADSALLapSSVFSENIYKPPFRPKASDRE---- 355
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 380 edmagtLLNIRRTAIFVVLFLGYGY-YRAADISAGLASLGLLSFAAiaqMAPALLGGLVWRQANARGAIAGMVSGFLVWA 458
Cdd:cd11474 356 ------LLWVMRISVVVFGAIATLMaLTVESIYGLVELASDLVLVG---LFVPLLAGLYWKRANTYGALAAIIVGLVLRL 426
|
490 500 510
....*....|....*....|....*....|....
gi 1550380708 459 YV-LFLPSLGGPDNSH----IAST---VLSFLLP 484
Cdd:cd11474 427 LGgELLLGLPADIPPQlqgfPFSTlamVIGSLLP 460
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
810-989 |
2.66e-10 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 64.18 E-value: 2.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 810 HDILQPLNAARLYSSSLVERLGDSDNralVQNIDSSLESVEAILGAVLDISRLDtgaMKPRLQS--VPLDELLRRIETD- 886
Cdd:PRK09470 252 HELRTPLTRLQLATALLRRRQGESKE---LERIETEAQRLDSMINDLLVLSRNQ---QKNHLERetFKANSLWSEVLEDa 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 887 -FAPMARAKDIELVIMPTSLAARSDPNLLRRLVQNLVSNAIKYTlQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVF 965
Cdd:PRK09470 326 kFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALRYS-HTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIF 404
|
170 180
....*....|....*....|....*.
gi 1550380708 966 KEFARLEEgARTAS--GLGLGLSIVD 989
Cdd:PRK09470 405 RPFYRVDE-ARDREsgGTGLGLAIVE 429
|
|
| Response_reg |
pfam00072 |
Response regulator receiver domain; This domain receives the signal from the sensor partner in ... |
1044-1154 |
2.73e-10 |
|
Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.
Pssm-ID: 395025 [Multi-domain] Cd Length: 111 Bit Score: 58.70 E-value: 2.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1044 VICIDNEPKILEGMALLLGGWGCSVTTAESLAACTEMAPGRlgvRPDAIIADYHLGDGTGVEAIAAIRGLWQeSIPALMV 1123
Cdd:pfam00072 1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEE---RPDLILLDINMPGMDGLELLKRIRRRDP-TTPVIIL 76
|
90 100 110
....*....|....*....|....*....|..
gi 1550380708 1124 TADRSPEVRGAAERDGVSLQ-HKPVRPAALRA 1154
Cdd:pfam00072 77 TAHGDEDDAVEALEAGADDFlSKPFDPDELLA 108
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
910-1016 |
3.07e-10 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 58.66 E-value: 3.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 910 DPNLLRRLVQNLVSNAIKYTLQG---KVLVGVRRhGQTATIEVLDSGIGIPSSKFRTVFKEFARL-EEGARTASGLGLGL 985
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGgriRCILEKFR-LNRFLLTVSDSGPGIPPNLREEIFERFRQGdGSSTRAHGGTGLGL 79
|
90 100 110
....*....|....*....|....*....|.
gi 1550380708 986 SIVDRISRVLNHPVGLQSKPGKGTGFKVTVP 1016
Cdd:cd16925 80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| AtoC |
COG2204 |
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ... |
1043-1154 |
3.36e-10 |
|
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];
Pssm-ID: 441806 [Multi-domain] Cd Length: 418 Bit Score: 63.44 E-value: 3.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1043 NVICIDNEPKILEGMALLLGGWGCSVTTAESLAACTEMAPGRlgvRPDAIIADYHLGDGTGVEAIAAIRGLWQEsIPALM 1122
Cdd:COG2204 4 RILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREE---PPDLVLLDLRMPGMDGLELLRELRALDPD-LPVIL 79
|
90 100 110
....*....|....*....|....*....|....
gi 1550380708 1123 VTADRSPEVRGAAERDGVS--LQhKPVRPAALRA 1154
Cdd:COG2204 80 LTGYGDVETAVEAIKAGAFdyLT-KPFDLEELLA 112
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
914-1017 |
5.05e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 57.83 E-value: 5.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 914 LRRLVQNLVSNAIKYTlQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEG-ARTASGLGLGLSIVDRIS 992
Cdd:cd16939 1 MARALDNLLRNALRYA-HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSrDRATGGFGLGLAIVHRVA 79
|
90 100
....*....|....*....|....*
gi 1550380708 993 RVLNHPVGLQSKPGKGTGFKVTVPL 1017
Cdd:cd16939 80 LWHGGHVECDDSELGGACFRLTWPR 104
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
911-1017 |
1.58e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 56.28 E-value: 1.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 911 PNLLRRLVQNLVSNAIK-YTLQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEgarTASGLGLGLSIVD 989
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQaMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKP---VGEGTGLGLSLSY 77
|
90 100
....*....|....*....|....*...
gi 1550380708 990 RISRVLNHPVGLQSKPGKGTGFKVTVPL 1017
Cdd:cd16943 78 RIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
910-1011 |
1.72e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 56.31 E-value: 1.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 910 DPNLLRRLVQNLVSNAIKYTLQ-GKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLeegARTASG---LGLGL 985
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEgGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSL---PRPHSGqksTGLGL 77
|
90 100
....*....|....*....|....*.
gi 1550380708 986 SIVDRISRVLNHPVGLQSKPGKGTGF 1011
Cdd:cd16945 78 AFVQEVAQLHGGRITLRNRPDGVLAF 103
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
801-865 |
1.75e-09 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 54.91 E-value: 1.75e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1550380708 801 KTRFFAAAGHDILQPLNAARLYSSSLVERLGDSDNRALVQNIDSSLESVEAILGAVLDISRLDTG 865
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
868-1017 |
1.79e-09 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 61.42 E-value: 1.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 868 KP---RLQSVPLDELLRRIETDFAPMARAKDIELVI-MPTSLAARSDPNLLRRLVQNLVSNAIKYTLQGKVL-VGVRRHG 942
Cdd:COG5806 262 KPqpeKLEKIDVSEELEHVIDVLSPYANMNNVEIQTeLEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLtIDVSIDK 341
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1550380708 943 QTATIEVLDSGIGIpsSKfrtvfKEFARLEEGART--ASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPL 1017
Cdd:COG5806 342 NKVIISIKDTGVGM--TK-----EQLERLGEPYFStkEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPL 411
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
844-1023 |
5.49e-09 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 60.03 E-value: 5.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 844 SSLESVEAILGAVLD----ISRLDTGAMKPRLQSVPLDELLRRIETDFAPMARAKDIELVI-MPTSLAARSDPNLLRRLV 918
Cdd:PRK10549 278 ASLQAEVGTLTKLVDdlhqLSLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLsLPDSATVFGDPDRLMQLF 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 919 QNLVSNAIKYT-LQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEGARTAS-GLGLGLSIVDRIsrVLN 996
Cdd:PRK10549 358 NNLLENSLRYTdSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASgGSGLGLAICLNI--VEA 435
|
170 180
....*....|....*....|....*....
gi 1550380708 997 HPVGLQSKPGKGTGFKVTV--PLDKSAGG 1023
Cdd:PRK10549 436 HNGRIIAAHSPFGGVSITVelPLERDLQR 464
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
801-865 |
5.61e-09 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 53.34 E-value: 5.61e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1550380708 801 KTRFFAAAGHDILQPLNAARLYSSSLVERLGDSDNRALVQNIDSSLESVEAILGAVLDISRLDTG 865
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| PleD |
COG3706 |
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ... |
1042-1154 |
6.30e-09 |
|
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];
Pssm-ID: 442920 [Multi-domain] Cd Length: 179 Bit Score: 56.84 E-value: 6.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1042 LNVICIDNEPKILEGMALLLGGWGCSVTTAESLAACTEMApgrLGVRPDAIIADYHLGDGTGVEAIAAIRGLWQ-ESIPA 1120
Cdd:COG3706 2 ARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELL---QEHRPDLILLDLEMPDMDGLELCRRLRADPRtADIPI 78
|
90 100 110
....*....|....*....|....*....|....*
gi 1550380708 1121 LMVTADRSPEVRGAAERDGVSLQ-HKPVRPAALRA 1154
Cdd:COG3706 79 IFLTALDDEEDRARALEAGADDYlTKPFDPEELLA 113
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
914-1017 |
9.31e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 54.25 E-value: 9.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 914 LRRLVQNLVSNAIKYTlQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEgARTAS--GLGLGLSIVDRI 991
Cdd:cd16949 1 LARALENVLRNALRYS-PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDS-ARDREsgGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 1550380708 992 SRvlNHPVGLQSKPGKGTGFKVTVPL 1017
Cdd:cd16949 79 IE--QHGGKIKASNRKPGGLRVRIWL 102
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
870-1016 |
1.07e-08 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 59.02 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 870 RLQSVPLD---ELLRRIETdFAPMARAKDIELVIMPTSLAARSDPNLLRRLVQNLVSNAIKYTLQGK-VLVGVRRHGQTA 945
Cdd:PRK09835 330 IPEKKMLDladEVGKVFDF-FEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEaITVRCQEVDHQV 408
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1550380708 946 TIEVLDSGIGIPSSKFRTVFKEFARLEEG-ARTASGLGLGLSIVDRISRVLNHPVGLQSKPgKGTGFKVTVP 1016
Cdd:PRK09835 409 QLVVENPGTPIAPEHLPRLFDRFYRVDPSrQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
|
|
| REC_RpfG-like |
cd17551 |
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ... |
1043-1154 |
2.91e-08 |
|
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.
Pssm-ID: 381103 [Multi-domain] Cd Length: 118 Bit Score: 53.21 E-value: 2.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1043 NVICIDNEP---KILEGMALLLGGWGCSVTT--AESLAACTEmapgrlgVRPDAIIADYHLGDGTGVEAIAAIRGLWQES 1117
Cdd:cd17551 2 RILIVDDNPtnlLLLEALLRSAGYLEVVSFTdpREALAWCRE-------NPPDLILLDYMMPGMDGLEFIRRLRALPGLE 74
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1550380708 1118 -IPALMVTADRSPEVRGAAERDGVS--LqHKPVRPAALRA 1154
Cdd:cd17551 75 dVPIVMITADTDREVRLRALEAGATdfL-TKPFDPVELLA 113
|
|
| OmpR |
COG0745 |
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ... |
1047-1154 |
3.93e-08 |
|
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];
Pssm-ID: 440508 [Multi-domain] Cd Length: 204 Bit Score: 54.96 E-value: 3.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1047 IDNEPKILEGMALLLGGWGCSVTTAESLAACTEMAPGRlgvRPDAIIADYHLGDGTGVEAIAAIRGlWQESIPALMVTAD 1126
Cdd:COG0745 7 VEDDPDIRELLADALEREGYEVDTAADGEEALELLEEE---RPDLILLDLMLPGMDGLEVCRRLRA-RPSDIPIIMLTAR 82
|
90 100 110
....*....|....*....|....*....|
gi 1550380708 1127 RSPEVRGAAERDGVS--LQhKPVRPAALRA 1154
Cdd:COG0745 83 DDEEDRVRGLEAGADdyLT-KPFDPEELLA 111
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
914-1016 |
3.93e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 52.40 E-value: 3.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 914 LRRLVQNLVSNAIKYTLQGKV-----LVGVRRHGQTA-TIEVLDSGIGIPSSKFRTVFKEFArleegARTASGLGLGLSI 987
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCerrelTIRTSPADDRAvTISVKDTGPGIAEEVAGQLFDPFY-----TTKSEGLGMGLSI 75
|
90 100
....*....|....*....|....*....
gi 1550380708 988 VDRISRVLNHPVGLQSKPGKGTGFKVTVP 1016
Cdd:cd16920 76 CRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
745-1020 |
1.12e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 54.24 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 745 IVTTYTDITQRVAADMALKQANETLELRVAERtgELTRVNRELgearaaaeeanigktrffaaagHD-ILQPLNAARLYS 823
Cdd:COG4585 21 LLALVLLRARRAERAAELERELAARAEEAREE--ERRRIAREL----------------------HDgVGQSLSAIKLQL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 824 SSLvERLGDSDNRALVQNIDSSLESVEAILGAVLDISRldtgamkpRLQSVPLDE--LLRRIETDFAPMARAKDIELVI- 900
Cdd:COG4585 77 EAA-RRLLDADPEAAREELEEIRELAREALAELRRLVR--------GLRPPALDDlgLAAALEELAERLLRAAGIRVELd 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 901 ---MPTSLAARSDPNLLRrLVQNLVSNAIKYTLQGKVLVGVRRHGQTATIEVLDSGIGIPsskfrtvfkefarleEGART 977
Cdd:COG4585 148 vdgDPDRLPPEVELALYR-IVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGVGFD---------------PEAAP 211
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1550380708 978 ASGLGLgLSIVDRISRVlnhpvG----LQSKPGKGTGFKVTVPLDKS 1020
Cdd:COG4585 212 GGGLGL-RGMRERAEAL-----GgtltIGSAPGGGTRVRATLPLAAA 252
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
870-1021 |
3.31e-07 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 54.53 E-value: 3.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 870 RLQSVPLDELLRRIETDFAPMARAKDIELVI------------MPTSLAarsdpnllrrlVQNLVSNAIKY----TLQGK 933
Cdd:COG3920 355 DWEGVDLRDYLRELLEPLRDSYGGRGIRIELdgpdvelpadaaVPLGLI-----------LNELVTNALKHaflsGEGGR 423
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 934 VLVGVRRHGQTATIEVLDSGIGIPsskfrtvfkefarleEGARTASGLGLGLSIVDRISRVLNHPVGLQSkpGKGTGFKV 1013
Cdd:COG3920 424 IRVSWRREDGRLRLTVSDNGVGLP---------------EDVDPPARKGLGLRLIRALVRQLGGTLELDR--PEGTRVRI 486
|
....*...
gi 1550380708 1014 TVPLDKSA 1021
Cdd:COG3920 487 TFPLAELA 494
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
913-1019 |
4.24e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 53.87 E-value: 4.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 913 LLRRLVQNLVSNAIKYTL-----QGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEGartaSGLGLgLSI 987
Cdd:COG2972 336 IPKLILQPLVENAIEHGIepkegGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKGEG----RGIGL-RNV 410
|
90 100 110
....*....|....*....|....*....|....
gi 1550380708 988 VDRISRVLNHPVGLQ--SKPGKGTGFKVTVPLDK 1019
Cdd:COG2972 411 RERLKLYYGEEYGLEieSEPGEGTTVTIRIPLEE 444
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
836-1152 |
4.44e-07 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 54.30 E-value: 4.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 836 RALVQNIDSSLESVEAILGAVLDISRLDTGAMKPrlqsVPLDELLRRIetdfAPMARAK-----DIELVIMPTSLAARSD 910
Cdd:PRK13837 486 ARYIDEIISAGARARLIIDQILAFGRKGERNTKP----FDLSELVTEI----APLLRVSlppgvELDFDQDQEPAVVEGN 557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 911 PNLLRRLVQNLVSNAIK-YTLQGKVLVGVRRH---------------GQTATIEVLDSGIGIPSSKFRTVFKEF--ARle 972
Cdd:PRK13837 558 PAELQQVLMNLCSNAAQaMDGAGRVDISLSRAklrapkvlshgvlppGRYVLLRVSDTGAGIDEAVLPHIFEPFftTR-- 635
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 973 egartASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPLdkSAGGRLKPQSVAAAKTSEALAGLNVICIDNEPK 1052
Cdd:PRK13837 636 -----AGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPP--SSKVPVAPQAFFGPGPLPRGRGETVLLVEPDDA 708
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1053 IL---EGMALLLG----GwgcSVTTAESLAACTEMapgrlGVRPDAIIADYHLGDGTGveAIAAIRGLWQeSIPALMVTA 1125
Cdd:PRK13837 709 TLeryEEKLAALGyepvG---FSTLAAAIAWISKG-----PERFDLVLVDDRLLDEEQ--AAAALHAAAP-TLPIILGGN 777
|
330 340
....*....|....*....|....*..
gi 1550380708 1126 DRSPEVRGAAERDGVSLQHKPVRPAAL 1152
Cdd:PRK13837 778 SKTMALSPDLLASVAEILAKPISSRTL 804
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
801-861 |
4.60e-07 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 47.98 E-value: 4.60e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1550380708 801 KTRFFAAAGHDILQPLNAARLYSSSLVERLGDSD-NRALVQNIDSSLESVEAILGAVLDISR 861
Cdd:cd00082 4 KGEFLANVSHELRTPLTAIRGALELLEEELLDDEeQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
910-1015 |
8.10e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 48.61 E-value: 8.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 910 DPNLLRRLVQNLVSNAIKYTLQGK-VLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEGARTASGLGLGLSIV 988
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGtVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIA 80
|
90 100
....*....|....*....|....*..
gi 1550380708 989 DRISRVLNHPVGLqSKPGKGtGFKVTV 1015
Cdd:cd16975 81 KNLVEKHGGSLII-ENSQKG-GAEVTV 105
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
7-463 |
8.78e-07 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 52.98 E-value: 8.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 7 IFASAFAYLLLLFAVASYGDRRARRN------EIAAKGR---PLVYALSL-AIYCTSWTYFGGVGLAAERGLEFtgIYIG 76
Cdd:cd10327 1 VLLPIIIYLVILLGIGFYARRSKKRRsgdfleEYFIGGRsmgGFVLAMTLvATYTSASSFIGGPGAAYKIGLGW--VLLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 77 ----PILMFTLGMpLIRRIVRLAKTEKLTSVADFVAARYgKNPAVAAIVALISLVGAIPYIALQLkavsSSVATMIdtsd 152
Cdd:cd10327 79 miqvPTGFLTLGV-LGKKFAIIARKINAVTIIDYLRARY-NSKALVVLSSLALIVFFIAAMVAQF----IGGARLL---- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 153 ygigsgENFVDLPLLVTLFLACFAIVF-----GTRHTDATEHQDGLILAIAMesVVKLVAMLTVGvyivfvlfGGPANLW 227
Cdd:cd10327 149 ------EAVTGLSYVTGLLIFGLTVILyttigGFRAVALTDAIQGIVMIIGT--VLLLVGVLAAG--------GGMEAIM 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 228 AEAQQS--ATVIAALEYQTPVARWILMIALSAFGIIMLPrQFHVTVVENRTDNELRTAgilfplylIAINAFVLPIAIAG 305
Cdd:cd10327 213 ATLAEIdpNLLTPFGPGFLSPPYILSFWVLVGFGVIGLP-QTAVRCMGYKDSKSMHRA--------MIIGTVVVGFLMLG 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 306 ILTfsgSGNADLYLLALPLAGD--VPLVTLFT--------FIGGFSAAtAMVIVASVALSImvSNDIVMPVFLRrrlgtr 375
Cdd:cd10327 284 MHL---AGVLGRAVLPDLEVPDkvIPTLALKVlppwlaglFLAGPLAA-IMSTVDSQLILA--SSAIVKDLYLN------ 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 376 gSLQEDMAGTLLNIRRTAIFVVLFLGYGYYRAA-DISAGLASLGLLSFAA--IAQMAPaLLGGLVWRQANARGAIAGMVS 452
Cdd:cd10327 352 -YKNKEKKTSEKKVKRISLIITIILGLLVFLLAiNPPDLIVWLNLFAFGGleAAFFWP-LVLGLYWKRANATGALASMVV 429
|
490
....*....|.
gi 1550380708 453 GFLVWAYVLFL 463
Cdd:cd10327 430 GLVSYILITYL 440
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
800-1017 |
1.04e-06 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 53.01 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 800 GKTRFFAAAGHDILQPLNAArlysSSLVERLGDSDNRALVQN-IDSSLESVEAILGAVLDIS---RLDTGAMKPRLQSVP 875
Cdd:PRK10618 449 ARKAFLQNIGDELKQPLQSL----AQLAAQLRQTSDEEQQQPeLDQLAEQSDVLVRLVDNIQllnMLETQDWKPEQELFS 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 876 LDELLRRIETDFAPMARAKDIELVI---MPTSLAARSDPNLLRRLVQNLVSNAIKYTLQGKVLVGVRRHGQTA---TIEV 949
Cdd:PRK10618 525 LQDLIDEVLPEVLPAIKRKGLQLLIhnhLKAEQLRIGDRDALRKILLLLLNYAITTTAYGKITLEVDQDESSPdrlTIRI 604
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1550380708 950 LDSGIGIPSSKFRTVFKEFARLEEGARTASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPL 1017
Cdd:PRK10618 605 LDTGAGVSIKELDNLHFPFLNQTQGDRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKM 672
|
|
| COG4567 |
COG4567 |
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ... |
1043-1158 |
1.08e-06 |
|
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];
Pssm-ID: 443624 [Multi-domain] Cd Length: 177 Bit Score: 49.91 E-value: 1.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1043 NVICIDNEPKILEGMALLLGGWGCSVTTAESLAACTEMAPGRlgvRPDAIIADYHLGDGTGVEAIAAIRGLwQESIPALM 1122
Cdd:COG4567 6 SLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQA---PPDYAVLDLRLGDGSGLDLIEALRER-DPDARIVV 81
|
90 100 110
....*....|....*....|....*....|....*...
gi 1550380708 1123 VTADRSPEVRGAAERDGVS--LQhKPVRPAALRAWLTQ 1158
Cdd:COG4567 82 LTGYASIATAVEAIKLGADdyLA-KPADADDLLAALER 118
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
634-860 |
1.09e-06 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 51.56 E-value: 1.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 634 QASEALQYNQDMLHTALSQMDQGIAVFDNANNLIIWNRRFRELMDLPEAAgQVGFPLADIVAILARrgdvrkDEEKALIA 713
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEE-LLGKTLRDLLPPEDD------DEFLELLR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 714 NFLTLDKPFLLELA-----GGARILEVRSNAMPDK-----GIVTTYTDITQRVAADMALKQANETLELRVAE-------- 775
Cdd:COG2202 74 AALAGGGVWRGELRnrrkdGSLFWVELSISPVRDEdgeitGFVGIARDITERKRAEEALRESEERLRLLVENapdgifvl 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 776 -RTGELTRVNRELGEARAAAEEANIGKTRFF------AAAGHDILQPLNAARLYSSSLVERLGDSDNRALV----QNIDS 844
Cdd:COG2202 154 dLDGRILYVNPAAEELLGYSPEELLGKSLLDllhpedRERLLELLRRLLEGGRESYELELRLKDGDGRWVWveasAVPLR 233
|
250
....*....|....*.
gi 1550380708 845 SLESVEAILGAVLDIS 860
Cdd:COG2202 234 DGGEVIGVLGIVRDIT 249
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
942-1016 |
1.14e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 48.53 E-value: 1.14e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1550380708 942 GQTATIEVLDSGIGIPSSKFRTVFKEFARLEEgarTASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVP 1016
Cdd:cd16919 45 GNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKE---VGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
809-991 |
1.94e-06 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 52.00 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 809 GHDILQPLNAARLYSSSL---VERLGDSDNRALVQNIDSSLESVEAILGAVLDISRLDTGAmkprLQSVPLDELLRRIET 885
Cdd:COG4192 441 AHELNQPLNAMSMYLFSAkkaLEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTP----LQPVDLRQVIEQAWE 516
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 886 DFAPMARAKDIELVImPTSLAARSDPNLLRRLVQNLVSNAIK-YTLQGKVLVGVRRHGQTATIEVLDSGIGIPSSKfrTV 964
Cdd:COG4192 517 LVESRAKPQQITLHI-PDDLMVQGDQVLLEQVLVNLLVNALDaVATQPQISVDLLSNAENLRVAISDNGNGWPLVD--KL 593
|
170 180
....*....|....*....|....*..
gi 1550380708 965 FKEFARLEEgartaSGLGLGLSIVDRI 991
Cdd:COG4192 594 FTPFTTTKE-----VGLGLGLSICRSI 615
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
921-992 |
2.17e-06 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 47.99 E-value: 2.17e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1550380708 921 LVSNAIKYTLQ----GKVLVGVRRHGQTATIEVLDSGIGIPsskfrtvfkeFARLEEGARTASGLGLGLSIVDRIS 992
Cdd:COG2172 42 AVTNAVRHAYGgdpdGPVEVELELDPDGLEIEVRDEGPGFD----------PEDLPDPYSTLAEGGRGLFLIRRLM 107
|
|
| AmiR |
COG3707 |
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ... |
1041-1156 |
2.55e-06 |
|
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];
Pssm-ID: 442921 [Multi-domain] Cd Length: 194 Bit Score: 49.18 E-value: 2.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1041 GLNVICIDNEPKILEGMALLLGGWGCSV-TTAESLAACTEMApgrLGVRPDAIIADYHLGDGTGVEAIAAIRGlwQESIP 1119
Cdd:COG3707 3 GLRVLVVDDEPLRRADLREGLREAGYEVvAEAADGEDAVELV---RELKPDLVIVDIDMPDRDGLEAARQISE--ERPAP 77
|
90 100 110
....*....|....*....|....*....|....*...
gi 1550380708 1120 ALMVTADRSPEVRGAAERDGVSLQ-HKPVRPAALRAWL 1156
Cdd:COG3707 78 VILLTAYSDPELIERALEAGVSAYlVKPLDPEDLLPAL 115
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
918-1016 |
2.81e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 46.90 E-value: 2.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 918 VQNLVSNAIKYTL-----QGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFkefarlEEGART--ASGLGLGLSIVDR 990
Cdd:cd16915 5 VGNLIDNALDALAatgapNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVF------ERGVSTkgQGERGIGLALVRQ 78
|
90 100
....*....|....*....|....*.
gi 1550380708 991 ISRVLNHPVGLQSKPGKGTGFKVTVP 1016
Cdd:cd16915 79 SVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
914-1016 |
3.32e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 46.61 E-value: 3.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 914 LRRLVQNLVSNAIKYTLQ-GKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEgARTASGLGLGLSIVDRIS 992
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPEnTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN-SRNTEGAGLGLSIAKAII 79
|
90 100
....*....|....*....|....
gi 1550380708 993 RVLNHPVGLQSKpGKGTGFKVTVP 1016
Cdd:cd16923 80 ELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
917-1016 |
4.08e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 46.67 E-value: 4.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 917 LVQNLVSNAIKYTLQ-----GKVLVGVRRHGQTATIEVLDSGIGIPsskfrtvfkefARLEE--GARTASGLGLGLSIVD 989
Cdd:cd16924 5 TLQPLVENAIQHGLSpltdkGVVTISALKEDNHVMIEVEDNGRGID-----------PKVLNilGKKPKEGNGIGLYNVH 73
|
90 100 110
....*....|....*....|....*....|
gi 1550380708 990 -RISRVLNHPVGL--QSKPGKGTGFKVTVP 1016
Cdd:cd16924 74 qRLILLFGEDYGIhiASEPDKGTRITFTIP 103
|
|
| REC_hyHK_CKI1_RcsC-like |
cd17546 |
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ... |
1048-1156 |
4.77e-06 |
|
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.
Pssm-ID: 381099 [Multi-domain] Cd Length: 113 Bit Score: 46.69 E-value: 4.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1048 DNEP--KILEGMallLGGWGCSVTTAES----LAACTEMapgrlgvRPDAIIADYHLGDGTGVEAIAAIRGL--WQESIP 1119
Cdd:cd17546 6 DNPVnrKVLKKL---LEKLGYEVDVAENgqeaLELLKEE-------PFDLVLMDLQMPVMDGLEATRRIRELegGGRRTP 75
|
90 100 110
....*....|....*....|....*....|....*...
gi 1550380708 1120 ALMVTADRSPEVRGAAERDGVS-LQHKPVRPAALRAWL 1156
Cdd:cd17546 76 IIALTANALEEDREKCLEAGMDdYLSKPVKLDQLKEVL 113
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
912-1016 |
7.97e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 45.85 E-value: 7.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 912 NLLRRLVQNLVSNAIKYTLQGKVLVGVR----RHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEGartasGLGLGLSI 987
Cdd:cd16918 7 NLVRNAAQALAGSGGEIILRTRTQRQVTlghpRHRLALRVSVIDNGPGIPPDLQDTIFYPMVSGREN-----GTGLGLAI 81
|
90 100
....*....|....*....|....*....
gi 1550380708 988 VDRISRVLNHPVGLQSKPGKgTGFKVTVP 1016
Cdd:cd16918 82 AQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
917-1017 |
3.64e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 43.96 E-value: 3.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 917 LVQNLVSNAIKYTLQ-----GKVLVGVRRHGQTATIEVLDSGIGipsskfrtvFKEFARLEEGARTASGLGLGLsIVDRI 991
Cdd:cd16956 5 TLQPIVENAVKHGLSglldgGRVEITARLDGQHLLLEVEDNGGG---------MDPDTLARILIRSSNGLGLNL-VDKRL 74
|
90 100
....*....|....*....|....*.
gi 1550380708 992 SRVLNHPVGLQSKPGKGTGFKVTVPL 1017
Cdd:cd16956 75 RQAFGNDYGLDIECAPGEGTRITIRL 100
|
|
| REC_NarL-like |
cd17535 |
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ... |
1044-1141 |
6.30e-05 |
|
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.
Pssm-ID: 381090 [Multi-domain] Cd Length: 117 Bit Score: 43.65 E-value: 6.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1044 VICIDNEPKILEGMALLLG--GWGCSVTTAESLAACTEMAPGRlgvRPDAIIADYHLGDGTGVEAIAAIRGLWQeSIPAL 1121
Cdd:cd17535 1 VLIVDDHPLVREGLRRLLEsePDIEVVGEAADGEEALALLREL---RPDVVLMDLSMPGMDGIEALRRLRRRYP-DLKVI 76
|
90 100
....*....|....*....|
gi 1550380708 1122 MVTADRSPEVRGAAERDGVS 1141
Cdd:cd17535 77 VLTAHDDPEYVLRALKAGAA 96
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
910-991 |
1.15e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 43.39 E-value: 1.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 910 DPNLLRRLVQNLVSNAIKYTLqGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEgarTASGLGLGLSIVD 989
Cdd:cd16954 34 ERNDLMELLGNLLDNACKWCL-EFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDE---QRPGQGLGLAIAK 109
|
..
gi 1550380708 990 RI 991
Cdd:cd16954 110 EI 111
|
|
| REC_PhyR |
cd17540 |
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ... |
1044-1158 |
1.16e-04 |
|
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.
Pssm-ID: 381095 [Multi-domain] Cd Length: 117 Bit Score: 42.62 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1044 VICIDNEPKI---LEGMALLLGG--WGCSVTTAESLAACTEmapgrlgVRPDAIIADYHLGDG-TGVEAIAAIRGLwqES 1117
Cdd:cd17540 3 VLIIEDEPLIamdLEQIVEDLGHqvVGIARTRDEAVALARR-------ERPDLILADIQLADGsSGIDAVNEILTT--HD 73
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1550380708 1118 IPALMVTAdrSPE-VRGAAERDGVSLQHKPVRPAALRAWLTQ 1158
Cdd:cd17540 74 VPVIFVTA--YPErLLTGERPEPTFLITKPFDPEMVKAAISQ 113
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
918-1009 |
1.43e-04 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 42.36 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 918 VQNLVSNAIKYTLQGKVLVGVRRHGQTATIEVL--DSGIGIPSSKfrtvfkefARLEEGARTASGLGLGLSIVDRisrvL 995
Cdd:cd16934 30 VTELARNLLKHAGGGQVLLEVVAEGGRVALEILavDQGPGIADVD--------EALRDGFSTGGGLGLGLGGVRR----L 97
|
90
....*....|....
gi 1550380708 996 NHPVGLQSKPGKGT 1009
Cdd:cd16934 98 ADEFDLHSAPGRGT 111
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
40-453 |
1.48e-04 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 45.76 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 40 PLVYALSL-AIYCTSWTYFGGVGLAAERGLEftgiYIGPILMFTLGMPLIRRIVRLAKTEK-LTSVADFVAARYGKNpav 117
Cdd:TIGR00813 7 GWVVAASLfASYISASQFLGLPGAIYAYGFA----IGFYELGALVLLIILGWLFVPIFINNgAYTMPEYLEKRFGKR--- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 118 aaIVALISLVGAIPYIALQLKAVSSSVATMIDTSdygIGsgenfVDLPLLVTLFLACFAI--VFGtrhtdatehqdGL-- 193
Cdd:TIGR00813 80 --ILRGLSVLSLILYIFLYMSVDLFSGALLIELI---TG-----LDLYLSLLLLGAITILytVFG-----------GLka 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 194 -ILAIAMESVVKLVAMLTVGVYiVFVLFGGPANLWAEAQQSATVIA--------ALEYQTPVARWILMIalsaFGIIMLP 264
Cdd:TIGR00813 139 vVWTDTIQAVIMILGTFILPVF-AFSEVGGLGTFVEKASQAAPTNPspddlydfFRDPSTSDLPWGAGV----FGLPHVA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 265 RQFHVTVVE------NRTDNELRtAGILFPLYLIAINAF--VLPIAIAGILTFSG--------SGNADLY--LLALPLAG 326
Cdd:TIGR00813 214 LWYWTNQVIvqrclaAKSAKHAK-KGCLISGVLKLLPMFgaVLPGLIARALYTDIdpalagavNQNSDQAypLLVQELMP 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 327 dvPLVTLFTFIGGFSAA----TAMVIVASVAlsimVSNDIVMPVflRRRLGTRGSLqedmagtLLNIRRTAIFVVLFLGY 402
Cdd:TIGR00813 293 --PGLAGLFLAAILAAVmstlSSQLNSASTV----FTMDLYKKI--IRPNASGEKK-------IVMRGRIAVLVAAVIAG 357
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 1550380708 403 GYyrAADISAGLASLGLLSFA-AIAQMAPALLGGLVWRQANARGAIAGMVSG 453
Cdd:TIGR00813 358 FV--AAAQGGQVLQYVQEAFGgLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
914-991 |
2.14e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 41.79 E-value: 2.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 914 LRRLVQNLVSNAIKYTLQGKVLVGVRR--HGQTATIEVLDSGIGIPSSKFRTVFKEF-ARLEEGARTASGLGLGLSIVDR 990
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTGRITVSAmpTGKMVTISVEDEGPGIPQEKLESIFDRFyTERPANEAFGQHSGLGLSISRQ 80
|
.
gi 1550380708 991 I 991
Cdd:cd16953 81 I 81
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
634-762 |
2.33e-04 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 44.25 E-value: 2.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 634 QASEALQYNQDMLHTALSQMDQGIAVFDNANNLIIWNRRFRELMDLPEAAgQVGFPLADIVAILARRgDVRKDEEKALIA 713
Cdd:COG2202 127 RAEEALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEE-LLGKSLLDLLHPEDRE-RLLELLRRLLEG 204
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1550380708 714 NFLTLDKPFLLELAGGaRILEVRSNAMPD------KGIVTTYTDITQRVAADMAL 762
Cdd:COG2202 205 GRESYELELRLKDGDG-RWVWVEASAVPLrdggevIGVLGIVRDITERKRAEEAL 258
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
920-991 |
2.87e-04 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 45.01 E-value: 2.87e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1550380708 920 NLVSNAIKYTLQgKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARleegART-ASGLGLGLSIVDRI 991
Cdd:PRK10815 385 NVLDNACKYCLE-FVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQR----ADTlRPGQGLGLSVAREI 452
|
|
| YesN |
COG4753 |
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ... |
1043-1141 |
3.32e-04 |
|
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];
Pssm-ID: 443786 [Multi-domain] Cd Length: 103 Bit Score: 40.91 E-value: 3.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1043 NVICIDNEPKILEGMALLL---GGWGCsVTTAESLAACTEMApgrLGVRPDAIIADYHLGDGTGVEAIAAIRGLWQEsIP 1119
Cdd:COG4753 1 KVLIVDDEPLIREGLKRILeweAGFEV-VGEAENGEEALELL---EEHKPDLVITDINMPGMDGLELLEAIRELDPD-TK 75
|
90 100
....*....|....*....|..
gi 1550380708 1120 ALMVTADRSPEVRGAAERDGVS 1141
Cdd:COG4753 76 IIILSGYSDFEYAQEAIKLGAD 97
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
931-1016 |
3.41e-04 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 42.57 E-value: 3.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 931 QGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRT--------VFKEFARLEE----------GARTA------SGLGLGLS 986
Cdd:cd16916 69 EGTITLRAEHQGNQVVIEVSDDGRGIDREKIREkaiergliTADEAATLSDdevlnlifapGFSTAeqvtdvSGRGVGMD 148
|
90 100 110
....*....|....*....|....*....|
gi 1550380708 987 IVDRISRVLNHPVGLQSKPGKGTGFKVTVP 1016
Cdd:cd16916 149 VVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
848-1152 |
7.75e-04 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 43.51 E-value: 7.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 848 SVEAILGAVLDISRLDTG----AMKPRLQSVPLDelLRRIETDFAPMARAKDIELVIMPTSLA-----ARSDPNLLRRLV 918
Cdd:PRK13557 205 SVENIRAAAERAATLTQQllafARKQRLEGRVLN--LNGLVSGMGELAERTLGDAVTIETDLApdlwnCRIDPTQAEVAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 919 QNLVSNA----------------IKYTLQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKE-FARLEEGartaSGL 981
Cdd:PRK13557 283 LNVLINArdampeggrvtirtrnVEIEDEDLAMYHGLPPGRYVSIAVTDTGSGMPPEILARVMDPfFTTKEEG----KGT 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 982 GLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPL-DKSAGGRLKPQSVAAAKTSEAlaglNVICIDNEPKILEGMALL 1060
Cdd:PRK13557 359 GLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPAsDQAENPEQEPKARAIDRGGTE----TILIVDDRPDVAELARMI 434
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1061 LGGWGCSVTTAESLAACTEMAPGrlGVRPDAIIADYHL-GDGTGVEAIAAIRGLwQESIPALMVT--ADRSPEvRGAAER 1137
Cdd:PRK13557 435 LEDFGYRTLVASNGREALEILDS--HPEVDLLFTDLIMpGGMNGVMLAREARRR-QPKIKVLLTTgyAEASIE-RTDAGG 510
|
330
....*....|....*
gi 1550380708 1138 DGVSLQHKPVRPAAL 1152
Cdd:PRK13557 511 SEFDILNKPYRRAEL 525
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
891-1018 |
9.50e-04 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 43.36 E-value: 9.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 891 ARAKDIELVIMPTSLAARS-DPNLLRRLVQ---NLVSN---AIKYTLQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRT 963
Cdd:PRK11086 407 ARELGITLIISEDSQLPDSgDEDQVHELITilgNLIENaleAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDA 486
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1550380708 964 VFkefarlEEGART-ASGLGLGLSIVDRISRVLNHPVGLQSKPGKGTGFKVTVPLD 1018
Cdd:PRK11086 487 IF------DKGYSTkGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWD 536
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
914-1016 |
1.87e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 38.30 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 914 LRRLVQNLVSNAIKYTLQGKVLVGVRRHGQTATIEVLDSGIGIPsskfrtvfkefarlEEGARTASGLGLgLSIVDRISR 993
Cdd:cd16917 1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFD--------------GPAPPGGGGFGL-LGMRERAEL 65
|
90 100
....*....|....*....|....*.
gi 1550380708 994 V---LNHPvglqSKPGKGTGFKVTVP 1016
Cdd:cd16917 66 LggtLTIG----SRPGGGTRVTARLP 87
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
910-1017 |
2.76e-03 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 41.22 E-value: 2.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 910 DPNLLRRLVQNLVSNAI--------KYTLQGKVLVGVRRHGQ----TATIEVLDSGIGIPSSKFRTVFKEFARLEEGart 977
Cdd:PRK11073 234 DPDQIEQVLLNIVRNALqalgpeggTITLRTRTAFQLTLHGEryrlAARIDIEDNGPGIPPHLQDTLFYPMVSGREG--- 310
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1550380708 978 asGLGLGLSIVDRISRVLNHPVGLQSKPGKgTGFKVTVPL 1017
Cdd:PRK11073 311 --GTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPI 347
|
|
| PRK10529 |
PRK10529 |
DNA-binding transcriptional activator KdpE; Provisional |
1043-1135 |
3.74e-03 |
|
DNA-binding transcriptional activator KdpE; Provisional
Pssm-ID: 182522 [Multi-domain] Cd Length: 225 Bit Score: 40.17 E-value: 3.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1043 NVICIDNEPKILEGMALLLGGWGCSVTTAESLAACTEMAPGRlgvRPDAIIADYHLGDGTGVEAIAAIRGlWQeSIPALM 1122
Cdd:PRK10529 3 NVLIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATR---KPDLIILDLGLPDGDGIEFIRDLRQ-WS-AIPVIV 77
|
90
....*....|...
gi 1550380708 1123 VTADRSPEVRGAA 1135
Cdd:PRK10529 78 LSARSEESDKIAA 90
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
13-456 |
4.06e-03 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 41.05 E-value: 4.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 13 AYLLLLFAVASYGDRRAR-RNEIAAKGRPLVYALSLAiyCTSWTYFGG------VGLAAERGLefTGIYigpiLMFTLGM 85
Cdd:cd11479 8 LYFAAMIAIGWWGMRRAKtSEDYLVAGRRLGPGLYLG--TMAAVVLGGastiggVGLGYQYGI--SGMW----LVVAIGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 86 PLI-------RRIVRLakteKLTSVADFVAARYGknPAVAAIVALISLVgaipyIALQLKAVSS-SVATMIDTsdygigs 157
Cdd:cd11479 80 GILalslllaKRIARL----KVYTVSEVLELRYG--PSARVISALVMLA-----YTLMVAVTSTiAIGTVFSV------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 158 genFVDLPLLVTLFLACFAIVFGTRHtdatehqdGLILAIAMESVVKLVAMlTVGVYIVFVLF-----GGPANLWAEAQQ 232
Cdd:cd11479 142 ---LFGLPRTLSILVGGGIVVLYSVL--------GGMWSITLTDIIQFVIK-TIGIFLLLLPLalskaGGLSGLQEKLPA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 233 SATVIAALEYQTpvarwILMIALSAFGIIMLPRQFHVTVVENRTDNELRTAGILFPLYLIAINAFVLPIAIAGILTFSGS 312
Cdd:cd11479 210 SYFDLTSIGWDT-----IVTYFLLYFFGILIGQDIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVLLPDL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 313 GNADLYLLALPLAgdvplvTLFTFIGGF---SAATAMVIVASVAL---SIMVSNDIVmPVFLRRRLGTRGSLQEDMAGTL 386
Cdd:cd11479 285 ANPQNAFATMAQE------VLPVGLRGLvlaAALAAMMSTASGALlasSTVLTNDVL-PRLRRKNESERSEVRLSRLFTL 357
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 387 LnIRRTAIFVVLFLGyGYYRAADISAGLASLGLLSfaaiaqmapALLGGLVWRQANARGAIAGMVSGFLV 456
Cdd:cd11479 358 L-LGVVVIVIAVLVN-DVVAALTIAYAILVGGLLV---------PILGGLFWKRATGAGALASMVAGSVV 416
|
|
| Stt3 |
COG1287 |
Asparagine N-glycosylation enzyme, membrane subunit Stt3 [Posttranslational modification, ... |
7-359 |
4.30e-03 |
|
Asparagine N-glycosylation enzyme, membrane subunit Stt3 [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440898 [Multi-domain] Cd Length: 774 Bit Score: 41.32 E-value: 4.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 7 IFASAFAYLLLLFAVASygdRRARRNEIAAKGRPLVYA----LSLAIYCTSWTyfGGVglaaergleftgIYIGPILMFT 82
Cdd:COG1287 172 LFFSTLAVLFLVLALKR---AKREKRDLEALKRPLLYAvlagVALGLYLLTWG--GYV------------LFVGILALFA 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 83 LGMPLIRRIVrlaktekltsvadfvaaryGKNPAVAAIVALISL-VGAIPYIALqlkavssSVATMIDTSDYGIGSGEnf 161
Cdd:COG1287 235 LLQLLLDLLR-------------------GRSPEYLAIVGAVSFaVAALLVLPF-------IPRLGFSGTGLSLLQPL-- 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 162 vdLPLLV---TLFLACFAIVFGTRHTDATehqdGLILAIAMESVVKLVAMLTVGVYIVFVLFGGPANLWAEAQQSATVia 238
Cdd:COG1287 287 --LALALaagTVFLAWLARELERRDLPRL----YYPAALVGLVAAGLALLAVLLPRVLAALIPGLRRFFGASALAATI-- 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 239 aLEYQTP-----VARWILMIALSAFGIIMLPRQFhvtVVENRTDNELRTAGILFPLYLIAINA-----FVLPIAI-AGIL 307
Cdd:COG1287 359 -AEAQPLtlsdlFSSFGIAFFLALIGLLLLLYRP---LRERRPELLFLLVWALFSIYAAFTQVrflyyLAVAVAIlAAIG 434
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1550380708 308 TFSGSGNADLYLLALPLAGDVPLVTLFTFiggfsAATAMVIVASVALSIMVS 359
Cdd:COG1287 435 LGELLDRLDLDKKKREAKKNINGVKILAV-----ALIVLLLLIPLSASIALS 481
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
40-453 |
4.87e-03 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 40.79 E-value: 4.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 40 PLVYALSL-AIYCTSWTYFGGVGLAAERGLEFTGIYIGpilmFTLGMPLIRRIV--RLAKTEKLTsVADFVAARYGKNPA 116
Cdd:pfam00474 10 GFVNGLSLaASYMSAASFVGLAGAGAASGLAGGLYAIG----ALVGVWLLLWLFapRLRNLGAYT-MPDYLRKRFGGKRI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 117 VAAIVALISLVGAIPYIALQLkavsSSVATMIDTSdygIGsgenfVDLPLLVTLFLACFAI--VFGtrhtdatehqdGLI 194
Cdd:pfam00474 85 LVYLSALSLLLYFFTYMSVQI----VGGARLIELA---LG-----LNYYTAVLLLGALTAIytFFG-----------GFL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 195 LAI---AMESVVKLVAMLTVGVyIVFVLFGGPANLWAEAQQSATVIAAL-------EYQTPVARWILMIALsAFGIIMLP 264
Cdd:pfam00474 142 AVSwtdTIQAVLMLFGTIILMI-IVFHEVGGYSSAVEKYMTADPNGVDLytpdglhILRDPLTGLSLWPGL-VLGTTGLP 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 265 rqfhVTVVENRTDNELRTA--------GILFPLYLIAINAFVLPIAIAGIL-----TFSGSGNADLYLLALPLAGDvplv 331
Cdd:pfam00474 220 ----HILQRCLAAKDAKCIrcgvliltPMFIIVMPGMISRGLFAIALAGANpracgTVVGCSNIAYPTLAVKLGPP---- 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 332 tlftFIGGFSAATAMVIVASVALSIMV--SNDIVMPVFLRRRlgtrgslQEDMAGTLLNIRRTAIFVVLFLGYGYYRAAD 409
Cdd:pfam00474 292 ----GLAGIMLAVMLAAIMSTLTSQLLssSSAFTHDLYKNIR-------RKASATEKELVGRSRIIVLVVISLAILLAVQ 360
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1550380708 410 I-SAGLASLGLLSFA-AIAQMAPALLGGLVWRQANARGAIAGMVSG 453
Cdd:pfam00474 361 PaQMGIAFLVQLAFAgLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406
|
|
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
15-456 |
5.03e-03 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 40.65 E-value: 5.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 15 LLLLFAVA----SYGDRRARRNEIAAK---------GRPLVYALSLAIYCTSWTYFGGVGLAAERGLEF-TGIYIGPILM 80
Cdd:cd11476 7 LGALFALLmvfiTRLLKRYRGKNQSSEefmtagrsvGTGLTAAAIVSSWTWAATLLQSATVAYQYGVSGpFWYASGATLQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 81 FTLGMPLIRRIVRLAKteKLTSVADFVAARYGKnpAVAAIVALISLVGAIPYIALQLKAVSSSVATMidtsdygigSGEN 160
Cdd:cd11476 87 ILLFAPLAIRIKRLAP--NAHTLLEIVRARYGT--AAHLVFLVFALFTNVIVLAMLLLGGSAVVNAL---------TGMP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 161 FVDLPLLVTLFLACFAIVFGTRHTdatehqdglILAIAMESVVKLVAMLTVGVYIVFVL-FGGP----ANLWAEAQQSAT 235
Cdd:cd11476 154 IVAASFLIPLGVLLYTLFGGLRAT---------FLTDYIHTVIILIILLVFAFAVYTSSdIGSPskvyDLLQEAAPDLPV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 236 VIAALEYQTPVARWILMialsaFGIIMLPRQFHVTVVENRTDNEL---RTAGILFPLYLIAINAFVLPIAIAGIL----- 307
Cdd:cd11476 225 EGNQGSYLTFKSKAGLI-----FGIINIVGNFGTVFLDQGYWQRAiaaRPSAAVKGYFLGGLAWFAIPFLLATTLglaal 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 308 -------TFSGSGNADLYLLALPLAGD--VPLVTLFTFIGGFSAATAMVIvasvALSIMVSNDIvmpvfLRRRLGTRGSL 378
Cdd:cd11476 300 alglnptFEEVSAGLVLPYVAAALLGKggAAAVLVLLFMAVTSTASAELI----AVSSIVTYDI-----YRTYINPNATG 370
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1550380708 379 QEDMAGTLLNIRRTAIFVVLFLGYGYYRAADisagLASLGLLSFAAIAQMAPALLGGLVWRQANARGAIAGMVSGFLV 456
Cdd:cd11476 371 KQLLRVSRIAVIGFGLFMGGLAVGLNYIGIS----LGWLLLFMGILIGSAVFPVALGLYWRRQTGTAAVVSPIAGLVA 444
|
|
| UhpB |
COG3851 |
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ... |
824-965 |
5.29e-03 |
|
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];
Pssm-ID: 443060 [Multi-domain] Cd Length: 493 Bit Score: 40.76 E-value: 5.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 824 SSLVERLGDSDNralvqnIDSSLESVEAILGAVLDISRldtgAMKPRLQSVPLDEL-----LRRIETDFAPMARAKDIEL 898
Cdd:COG3851 315 ASILKRLAPQPE------IEQSAQSIESLALRIYDTTR----RLLDRLRPAVLDELgleeaLRELPRELAFEEPGISCQL 384
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1550380708 899 VImptslaaRSDPNLLR--------RLVQNLVSNAIKYTLQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVF 965
Cdd:COG3851 385 DL-------RGDPSLLDdtlqltlyRLVQEALTNILKHAEASQIRISLSQDKRLLSLEIRDDGIGLPPELRAKGF 452
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
914-1013 |
5.40e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 37.82 E-value: 5.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 914 LRRLVQNLVSNA---IKYTLQGKVLVGVRRHGQTATIEVLDSGIGIPSSKFRTVFKEFARLEEGARtasGLGLGLSIVDR 990
Cdd:cd16976 1 IQQVLMNLLQNAldaMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGK---GTGLGLSISYG 77
|
90 100
....*....|....*....|...
gi 1550380708 991 ISRVLNHPVGLQSKPGKGTGFKV 1013
Cdd:cd16976 78 IVEEHGGRLSVANEEGAGARFTF 100
|
|
| REC_OmpR_KdpE-like |
cd17620 |
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ... |
1044-1130 |
9.61e-03 |
|
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.
Pssm-ID: 381135 [Multi-domain] Cd Length: 99 Bit Score: 36.76 E-value: 9.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1550380708 1044 VICIDNEPKILEGMALLLGGWGCSVTTAESLAACTEMAPGRlgvRPDAIIADYHLGDGTGVEAIAAIRGlWQEsIPALMV 1123
Cdd:cd17620 1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATR---KPDLIILDLGLPDMDGLEVIRRLRE-WSA-VPVIVL 75
|
....*..
gi 1550380708 1124 TAdRSPE 1130
Cdd:cd17620 76 SA-RDEE 81
|
|
| |
